analysis of sequence from tem9.fa
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
>gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
MRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPP
EPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCL
TSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTL
CAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAP
VEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAER
VANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVL
YTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLV
DEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGG
VPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPV
PPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAE
PVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCT
ALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSL
STLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYC
WLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLS
DSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVA
ASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGH
PLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACG
KNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAG
RAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETT
V
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
sec.str. with predator
> gi|17511205|ref|NP_116166.6|
. . . . .
1 MRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGG 50
_____EEEEEE__HHHHHH_____________EEEEEE____________
. . . . .
51 VPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGL 100
______EEEEE__________________EEEEE____EEE_______HH
. . . . .
101 SLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPR 150
HHHHHH______EEE___________EEEE______EEEEEEE_EEE___
. . . . .
151 LLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQN 200
EEEEE___EEE____________EEEEEE____EEEHHHHHHH_HHHHHH
. . . . .
201 RSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQV 250
HHHHHHHHEEEE___HHHHHHHHHHHHHHHHH__HHHHHHHH_HHHHHEE
. . . . .
251 VFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCT 300
EEE_________EEE____EEEE____________HHHHHHHHHHHH___
. . . . .
301 FITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAER 350
EEE__HHHHH_EEE_____EEEEEE_______EEEEEEEE_______HHH
. . . . .
351 VANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAG 400
HHH__________HHHHHHHHHH___________________HHHHHHH_
. . . . .
401 RWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASF 450
_________EEE____HHHHHHHH________HHHHHHHHHHHHHHHHHH
. . . . .
451 SDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQR 500
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH____HHHHHHHHHHHHHH
. . . . .
501 EDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLT 550
H__HHHHHHHH_EEE__________EEE___HHHHHEEEEE____EEEEE
. . . . .
551 CTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSS 600
EEE________________________________EEEEE__________
. . . . .
601 FHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSH 650
_____HHHHHHH___________EEE__________EEEEE____EEE__
. . . . .
651 SNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAE 700
___________________EEEEE_______________EEE_______H
. . . . .
701 PVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSA 750
HHHHHHH_______________EEE______EEE_______HHHHHHHH_
. . . . .
751 FPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHM 800
__________EEEEEEE___HHHHHHHHHHHHHHHH_____EEEE__HHH
. . . . .
801 LLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKA 850
HHHHHEEEEHHHHHH______HHHHHHHHHHH________HHHHHH__HH
. . . . .
851 RVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNI 900
HHHHHHHHH____________________EEE_____EEEEE____EEE_
. . . . .
901 HNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQN 950
_________EEEEE_____EEEHHHHHHHHHHHHHHHHHHH_________
. . . . .
951 PKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPE 1000
_____HHHHHHHHHHH__________________EEEE____________
. . . . .
1001 DGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVA 1050
____________EEEEEEHHHHHHHHH___________EEEEEEEEHHHH
. . . . .
1051 ASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGS 1100
HHHHHHEEEE______HHHHHHHH_________________HHHHH____
. . . . .
1101 PVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEG 1150
____________________EEE______HHHHHHHHHHH__________
. . . . .
1151 EPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGG 1200
__________________________________________HHHHHHH_
. . . . .
1201 AAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSD 1250
__HHHHHHH_________________________________________
. . . . .
1251 TSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPK 1300
___HHHHHHH____HHHHH_________HHHHHH________________
. . .
1301 GGKYDDVTLMGAEVASGGCMKTGLWKSETT 1330
______EEEE_EEEE______EEEE_____
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
method : 1
alpha-contents : 37.8 %
beta-contents : 5.0 %
coil-contents : 57.2 %
class : alpha
method : 2
alpha-contents : 13.8 %
beta-contents : 13.7 %
coil-contents : 72.5 %
class : beta
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
GPI: learning from metazoa
-4.44 0.00 0.00 0.00 0.00 0.00 -8.00 0.00 0.00 -6.52 -1.81 -12.00 -12.00 -4.00 -12.00 0.00 -60.76
0.27 0.00 0.00 0.00 0.00 0.00 -12.00 0.00 -0.02 -6.52 -1.81 -12.00 -12.00 -4.00 -12.00 0.00 -60.07
ID: gi|17511205|ref|NP_116166.6| AC: xxx Len: 1330 1:I 1316 Sc: -60.07 Pv: 3.710430e-01 NO_GPI_SITE
GPI: learning from protozoa
-22.75 -0.37 -0.56 -0.10 -4.00 0.00 -4.00 0.00 0.00 -5.66 -7.09 -12.00 -12.00 -4.00 -12.00 0.00 -84.52
-14.55 0.00 0.00 0.00 -4.00 0.00 -16.00 0.00 -0.36 -5.66 -7.09 -12.00 -12.00 0.00 -12.00 0.00 -83.65
ID: gi|17511205|ref|NP_116166.6| AC: xxx Len: 1330 1:I 1317 Sc: -83.65 Pv: 5.761400e-01 NO_GPI_SITE
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
# SignalP euk predictions
# name Cmax pos ? Ymax pos ? Smax pos ? Smean ?
gi|17511205 1.000 27 Y 0.910 27 Y 0.986 926 Y 0.938 Y
# SignalP gram- predictions
# name Cmax pos ? Ymax pos ? Smax pos ? Smean ?
gi|17511205 0.692 27 Y 0.615 27 Y 0.979 775 Y 0.718 Y
# SignalP gram+ predictions
# name Cmax pos ? Ymax pos ? Smax pos ? Smean ?
gi|17511205 0.653 897 Y 0.635 897 Y 0.971 774 Y 0.265 N
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
low complexity regions: SEG 12 2.2 2.5
>gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
1-1 M
rgaparlllpllpwlllllapeargapg 2-29
30-62 CPLSIRSCKCSGERPKGLSGGVPGPARRRV
VCS
ggdlpeppepgllp 63-76
77-572 NGTVTLLLSNNKITGLRNGSFLGLSLLEKL
DLRNNIISTVQPGAFLGLGELKRLDLSNNR
IGCLTSETFQGLPRLLRLNISGNIFSSLQP
GVFDELPALKVVDLGTEFLTCDCHLRWLLP
WAQNRSLQLSEHTLCAYPSALHAQALGSLQ
EAQLCCEGALELHTHHLIPSLRQVVFQGDR
LPFQCSASYLGNDTRIRWYHNRAPVEGDEQ
AGILLAESLIHDCTFITSELTLSHIGVWAS
GEWECTVSMAQGNASKKVEIVVLETSASYC
PAERVANNRGDFRWPRTLAGITAYQSCLQY
PFTSVPLGGGAPGTRASRRCDRAGRWEPGD
YSHCLYTNDITRVLYTFVLMPINASNALTL
AHQLRVYTAEAASFSDMMDVVYVAQMIQKF
LGYVDQIKELVEVMVDMASNLMLVDEHLLW
LAQREDKACSRIVGALERIGGAALSPHAQH
ISVNARNVALEAYLIKPHSYVGLTCTAFQR
REGGVPGTRPGSPGQN
pppepepp 573-580
581-613 ADQQLRFRCTTGRPNVSLSSFHIKNSVALA
SIQ
lppslfsslpaalappvpp 614-632
633-654 DCTLQLLVFRNGRLFHSHSNTS
rpgaagpgkrrg 655-666
667-768 VATPVIFAGTSGCGVGNLTEPVAVSLRHWA
EGAEPVAAWWSQEGPGEAGGWTSEGCQLRS
SQPNVSALHCQHLGNVAVLMELSAFPREVG
GAGAGLHPVVYP
ctallllclfatii 769-782
783-973 TYILNHSSIRVSRKGWHMLLNLCFHIAMTS
AVFAGGITLTNYQMVCQAVGITLHYSSLST
LLWMGVKARVLHKELTWRAPPPQEGDPALP
TPSPMLRFYLIAGGIPLIICGITAAVNIHN
YRDHSPYCWLVWRPSLGAFYIPVALILLIT
WIYFLCAGLRLRGPLAQNPKAGNSRASLEA
GEELRGSTRLR
gsgpllsdsgsll 974-986
987-1070 ATGSARVGTPGPPEDGDSLYSPGVQLGALV
TTHFLYLAMWACGALAVSQRWLPRVVCSCL
YGVAASALGLFVFTHHCARRRDVR
aswraccppaspaaphappralpaaa 1071-1096
1097-1103 EDGSPVF
gegppslksspsgssghplalgp 1104-1126
1127-1140 CKLTNLQLAQSQVC
eagaaaggegepepag 1141-1156
1157-1192 TRGNLAHRHPNNVHHGRRAHKSRAKGHRAG
EACGKN
rlkalrggaagalellssesgsl 1193-1215
1216-1256 HNSPTDSYLGSSRNSPGAGLQLEGEPMLTP
SEGSDTSAAPL
seagragqrrsasrds 1257-1272
1273-1331 LKGGGALEKESHRRSYPLNAASLNGAPKGG
KYDDVTLMGAEVASGGCMKTGLWKSETTV
low complexity regions: SEG 25 3.0 3.3
>gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
1-1 M
rgaparlllpllpwlllllapeargapgcp 2-114
lsirsckcsgerpkglsggvpgparrrvvc
sggdlpeppepgllpngtvtlllsnnkitg
lrngsflglsllekldlrnniis
115-201 TVQPGAFLGLGELKRLDLSNNRIGCLTSET
FQGLPRLLRLNISGNIFSSLQPGVFDELPA
LKVVDLGTEFLTCDCHLRWLLPWAQNR
slqlsehtlcaypsalhaqalgslqeaqlc 202-243
cegalelhthhl
244-555 IPSLRQVVFQGDRLPFQCSASYLGNDTRIR
WYHNRAPVEGDEQAGILLAESLIHDCTFIT
SELTLSHIGVWASGEWECTVSMAQGNASKK
VEIVVLETSASYCPAERVANNRGDFRWPRT
LAGITAYQSCLQYPFTSVPLGGGAPGTRAS
RRCDRAGRWEPGDYSHCLYTNDITRVLYTF
VLMPINASNALTLAHQLRVYTAEAASFSDM
MDVVYVAQMIQKFLGYVDQIKELVEVMVDM
ASNLMLVDEHLLWLAQREDKACSRIVGALE
RIGGAALSPHAQHISVNARNVALEAYLIKP
HSYVGLTCTAFQ
rreggvpgtrpgspgqnpppepepp 556-580
581-593 ADQQLRFRCTTGR
pnvslssfhiknsvalasiqlppslfsslp 594-640
aalappvppdctlqllv
641-685 FRNGRLFHSHSNTSRPGAAGPGKRRGVATP
VIFAGTSGCGVGNLT
epvavslrhwaegaepvaawwsqegpgeag 686-721
gwtseg
722-955 CQLRSSQPNVSALHCQHLGNVAVLMELSAF
PREVGGAGAGLHPVVYPCTALLLLCLFATI
ITYILNHSSIRVSRKGWHMLLNLCFHIAMT
SAVFAGGITLTNYQMVCQAVGITLHYSSLS
TLLWMGVKARVLHKELTWRAPPPQEGDPAL
PTPSPMLRFYLIAGGIPLIICGITAAVNIH
NYRDHSPYCWLVWRPSLGAFYIPVALILLI
TWIYFLCAGLRLRGPLAQNPKAGN
srasleageelrgstrlrgsgpllsdsgsl 956-1009
latgsarvgtpgppedgdslyspg
1010-1063 VQLGALVTTHFLYLAMWACGALAVSQRWLP
RVVCSCLYGVAASALGLFVFTHHC
arrrdvraswraccppaspaaphappralp 1064-1126
aaaedgspvfgegppslksspsgssghpla
lgp
1127-1140 CKLTNLQLAQSQVC
eagaaaggegepepagtrgnlahrhpnnvh 1141-1235
hgrrahksrakghrageacgknrlkalrgg
aagalellssesgslhnsptdsylgssrns
pgagl
1236-1242 QLEGEPM
ltpsegsdtsaaplseagragqrrsasrds 1243-1287
lkgggalekeshrrs
1288-1331 YPLNAASLNGAPKGGKYDDVTLMGAEVASG
GCMKTGLWKSETTV
low complexity regions: SEG 45 3.4 3.75
>gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
1-1 M
rgaparlllpllpwlllllapeargapgcp 2-175
lsirsckcsgerpkglsggvpgparrrvvc
sggdlpeppepgllpngtvtlllsnnkitg
lrngsflglsllekldlrnniistvqpgaf
lglgelkrldlsnnrigcltsetfqglprl
lrlnisgnifsslqpgvfdelpal
176-189 KVVDLGTEFLTCDC
hlrwllpwaqnrslqlsehtlcaypsalha 190-267
qalgslqeaqlccegalelhthhlipslrq
vvfqgdrlpfqcsasylg
268-555 NDTRIRWYHNRAPVEGDEQAGILLAESLIH
DCTFITSELTLSHIGVWASGEWECTVSMAQ
GNASKKVEIVVLETSASYCPAERVANNRGD
FRWPRTLAGITAYQSCLQYPFTSVPLGGGA
PGTRASRRCDRAGRWEPGDYSHCLYTNDIT
RVLYTFVLMPINASNALTLAHQLRVYTAEA
ASFSDMMDVVYVAQMIQKFLGYVDQIKELV
EVMVDMASNLMLVDEHLLWLAQREDKACSR
IVGALERIGGAALSPHAQHISVNARNVALE
AYLIKPHSYVGLTCTAFQ
rreggvpgtrpgspgqnpppepeppadqql 556-670
rfrcttgrpnvslssfhiknsvalasiqlp
pslfsslpaalappvppdctlqllvfrngr
lfhshsntsrpgaagpgkrrgvatp
671-939 VIFAGTSGCGVGNLTEPVAVSLRHWAEGAE
PVAAWWSQEGPGEAGGWTSEGCQLRSSQPN
VSALHCQHLGNVAVLMELSAFPREVGGAGA
GLHPVVYPCTALLLLCLFATIITYILNHSS
IRVSRKGWHMLLNLCFHIAMTSAVFAGGIT
LTNYQMVCQAVGITLHYSSLSTLLWMGVKA
RVLHKELTWRAPPPQEGDPALPTPSPMLRF
YLIAGGIPLIICGITAAVNIHNYRDHSPYC
WLVWRPSLGAFYIPVALILLITWIYFLCA
glrlrgplaqnpkagnsrasleageelrgs 940-1318
trlrgsgpllsdsgsllatgsarvgtpgpp
edgdslyspgvqlgalvtthflylamwacg
alavsqrwlprvvcsclygvaasalglfvf
thhcarrrdvraswraccppaspaaphapp
ralpaaaedgspvfgegppslksspsgssg
hplalgpckltnlqlaqsqvceagaaagge
gepepagtrgnlahrhpnnvhhgrrahksr
akghrageacgknrlkalrggaagalells
sesgslhnsptdsylgssrnspgaglqleg
epmltpsegsdtsaaplseagragqrrsas
rdslkgggalekeshrrsyplnaaslngap
kggkyddvtlmgaevasgg
1319-1331 CMKTGLWKSETTV
low complexity regions: XNU
# Score cutoff = 21, Search from offsets 1 to 4
# both members of each repeat flagged
# lambda = 0.347, K = 0.200, H = 0.664
>gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
MRGAPARLllpllpwlllllapeargapgcpLSIRSCKCSGERPKGLSGGVPGPARRRVV
CSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGA
FLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDL
GTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHT
HHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCT
FITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRW
PRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVL
YTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVM
VDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYL
IKPHSYVGLTCTAFQRREggvpgtrpgspgqnpppepeppadqqlrfrCTTGRPNVSLSS
FHIKNSVALASIQlppslfsslpaalappvppDCTLQLLVFRNGRLFHSHSNTSRPGAAG
PGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSE
GCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFAT
IITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSL
STLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNI
HNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASL
EAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHF
LYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRAccppa
spaaphappralpaaaedgspVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVC
EagaaaggegepepAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGG
AAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAG
RAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCM
KTGLWKSETTV
1 - 8 MRGAPARL
9 - 31 ll pllpwlllll apeargapgc p
32 - 558 LSIRSCKCS GERPKGLSGG VPGPARRRVV CSGGDLPEPP EPGLLPNGTV TLLLSNNKIT G
LRNGSFLGL SLLEKLDLRN NIISTVQPGA FLGLGELKRL DLSNNRIGCL TSETFQGLPR L
LRLNISGNI FSSLQPGVFD ELPALKVVDL GTEFLTCDCH LRWLLPWAQN RSLQLSEHTL C
AYPSALHAQ ALGSLQEAQL CCEGALELHT HHLIPSLRQV VFQGDRLPFQ CSASYLGNDT R
IRWYHNRAP VEGDEQAGIL LAESLIHDCT FITSELTLSH IGVWASGEWE CTVSMAQGNA S
KKVEIVVLE TSASYCPAER VANNRGDFRW PRTLAGITAY QSCLQYPFTS VPLGGGAPGT R
ASRRCDRAG RWEPGDYSHC LYTNDITRVL YTFVLMPINA SNALTLAHQL RVYTAEAASF S
DMMDVVYVA QMIQKFLGYV DQIKELVEVM VDMASNLMLV DEHLLWLAQR EDKACSRIVG A
LERIGGAAL SPHAQHISVN ARNVALEAYL IKPHSYVGLT CTAFQRRE
559 - 588 gg vpgtrpgspg qnpppepepp adqqlrfr
589 - 613 CT TGRPNVSLSS FHIKNSVALA SIQ
614 - 632 lppslfs slpaalappv pp
633 - 1075 DCTLQLLV FRNGRLFHSH SNTSRPGAAG PGKRRGVATP VIFAGTSGCG VGNLTEPVAV SL
RHWAEGAE PVAAWWSQEG PGEAGGWTSE GCQLRSSQPN VSALHCQHLG NVAVLMELSA FP
REVGGAGA GLHPVVYPCT ALLLLCLFAT IITYILNHSS IRVSRKGWHM LLNLCFHIAM TS
AVFAGGIT LTNYQMVCQA VGITLHYSSL STLLWMGVKA RVLHKELTWR APPPQEGDPA LP
TPSPMLRF YLIAGGIPLI ICGITAAVNI HNYRDHSPYC WLVWRPSLGA FYIPVALILL IT
WIYFLCAG LRLRGPLAQN PKAGNSRASL EAGEELRGST RLRGSGPLLS DSGSLLATGS AR
VGTPGPPE DGDSLYSPGV QLGALVTTHF LYLAMWACGA LAVSQRWLPR VVCSCLYGVA AS
ALGLFVFT HHCARRRDVR ASWRA
1076 - 1101 ccppa spaaphappr alpaaaedgs p
1102 - 1141 VFGEGPPSL KSSPSGSSGH PLALGPCKLT NLQLAQSQVC E
1142 - 1154 agaaaggeg epep
1155 - 1331 AGTRGN LAHRHPNNVH HGRRAHKSRA KGHRAGEACG KNRLKALRGG AAGALELLSS ESGS
LHNSPT DSYLGSSRNS PGAGLQLEGE PMLTPSEGSD TSAAPLSEAG RAGQRRSASR DSLK
GGGALE KESHRRSYPL NAASLNGAPK GGKYDDVTLM GAEVASGGCM KTGLWKSETT V
low complexity regions: DUST
>gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
MRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVV
CSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGA
FLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDL
GTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHT
HHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCT
FITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRW
PRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVL
YTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVM
VDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYL
IKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSS
FHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAG
PGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSE
GCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFAT
IITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSL
STLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNI
HNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASL
EAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHF
LYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPA
SPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVC
EAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGG
AAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAG
RAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCM
KTGLWKSETTV
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
coiled coil prediction for gi|17511205|ref|NP_116166.6|
sequence: 1330 amino acids, 0 residue(s) in coiled coil state
. | . | . | . | . | . 60
MRGAPARLLL PLLPWLLLLL APEARGAPGC PLSIRSCKCS GERPKGLSGG VPGPARRRVV
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 120
CSGGDLPEPP EPGLLPNGTV TLLLSNNKIT GLRNGSFLGL SLLEKLDLRN NIISTVQPGA
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 180
FLGLGELKRL DLSNNRIGCL TSETFQGLPR LLRLNISGNI FSSLQPGVFD ELPALKVVDL
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 240
GTEFLTCDCH LRWLLPWAQN RSLQLSEHTL CAYPSALHAQ ALGSLQEAQL CCEGALELHT
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 300
HHLIPSLRQV VFQGDRLPFQ CSASYLGNDT RIRWYHNRAP VEGDEQAGIL LAESLIHDCT
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 360
FITSELTLSH IGVWASGEWE CTVSMAQGNA SKKVEIVVLE TSASYCPAER VANNRGDFRW
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 420
PRTLAGITAY QSCLQYPFTS VPLGGGAPGT RASRRCDRAG RWEPGDYSHC LYTNDITRVL
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 480
YTFVLMPINA SNALTLAHQL RVYTAEAASF SDMMDVVYVA QMIQKFLGYV DQIKELVEVM
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~1222 2222222222 * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 540
VDMASNLMLV DEHLLWLAQR EDKACSRIVG ALERIGGAAL SPHAQHISVN ARNVALEAYL
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
2222222211 11~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 600
IKPHSYVGLT CTAFQRREGG VPGTRPGSPG QNPPPEPEPP ADQQLRFRCT TGRPNVSLSS
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 660
FHIKNSVALA SIQLPPSLFS SLPAALAPPV PPDCTLQLLV FRNGRLFHSH SNTSRPGAAG
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 720
PGKRRGVATP VIFAGTSGCG VGNLTEPVAV SLRHWAEGAE PVAAWWSQEG PGEAGGWTSE
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 780
GCQLRSSQPN VSALHCQHLG NVAVLMELSA FPREVGGAGA GLHPVVYPCT ALLLLCLFAT
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 840
IITYILNHSS IRVSRKGWHM LLNLCFHIAM TSAVFAGGIT LTNYQMVCQA VGITLHYSSL
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 900
STLLWMGVKA RVLHKELTWR APPPQEGDPA LPTPSPMLRF YLIAGGIPLI ICGITAAVNI
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 960
HNYRDHSPYC WLVWRPSLGA FYIPVALILL ITWIYFLCAG LRLRGPLAQN PKAGNSRASL
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 1020
EAGEELRGST RLRGSGPLLS DSGSLLATGS ARVGTPGPPE DGDSLYSPGV QLGALVTTHF
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 1080
LYLAMWACGA LAVSQRWLPR VVCSCLYGVA ASALGLFVFT HHCARRRDVR ASWRACCPPA
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 1140
SPAAPHAPPR ALPAAAEDGS PVFGEGPPSL KSSPSGSSGH PLALGPCKLT NLQLAQSQVC
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 1200
EAGAAAGGEG EPEPAGTRGN LAHRHPNNVH HGRRAHKSRA KGHRAGEACG KNRLKALRGG
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ 1111111111 * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 1260
AAGALELLSS ESGSLHNSPT DSYLGSSRNS PGAGLQLEGE PMLTPSEGSD TSAAPLSEAG
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
1111111111 1~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. | . | . | . | . | . 1320
RAGQRRSASR DSLKGGGALE KESHRRSYPL NAASLNGAPK GGKYDDVTLM GAEVASGGCM
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border
---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif.
~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local
. |
KTGLWKSETT
~~~~~~~~~~
----------
~~~~~~~~~~
~~~~~~~~~~
~~~~~~~~~~
~~~~~~~~~~
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
prediction of transmembrane regions with toppred2
***********************************
*TOPPREDM with eukaryotic function*
***********************************
tem9.fa.___inter___ is a single sequence
Using hydrophobicity file: /bio_software/2D/toppredm/lib/Engelman-Steitz.scale
Using cyt/ext file: /bio_software/2D/toppredm/lib/Cyt-Ext.prok
Using sequence file: tem9.fa.___inter___
(1 sequences)
MRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGG
VPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGL
SLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPR
LLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQN
RSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQV
VFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCT
FITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAER
VANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAG
RWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASF
SDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQR
EDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLT
CTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSS
FHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSH
SNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAE
PVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSA
FPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHM
LLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKA
RVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNI
HNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQN
PKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPE
DGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVA
ASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGS
PVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEG
EPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGG
AAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSD
TSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPK
GGKYDDVTLMGAEVASGGCMKTGLWKSETTV
(p)rokaryotic or (e)ukaryotic: e
Charge-pair energy: 0
Length of full window (odd number!): 21
Length of core window (odd number!): 11
Number of residues to add to each end of helix: 1
Critical length: 60
Upper cutoff for candidates: 1
Lower cutoff for candidates: 0.6
Total of 8 structures are to be tested
Candidate membrane-spanning segments:
Helix Begin End Score Certainity
1 4 24 1.242 Certain
2 298 318 0.713 Putative
3 370 390 0.833 Putative
4 419 439 0.996 Putative
5 612 632 1.228 Certain
6 666 686 1.308 Certain
7 766 786 2.172 Certain
8 803 823 1.680 Certain
9 828 848 1.319 Certain
10 880 900 1.827 Certain
11 921 941 2.223 Certain
12 1012 1032 1.698 Certain
13 1041 1061 1.833 Certain
----------------------------------------------------------------------
Structure 1
Transmembrane segments included in this structure:
Segment 1 3 4 5 6 7 8 9 10 11 12 13
Loop length 3 345 28 172 33 79 16 4 31 20 70 8 270
K+R profile 3.00 6.00 6.00 3.00 5.00 + +
+ + + 0.00 2.00 2.00
CYT-EXT prof - - - - - 0.31 0.24
-0.18 1.19 0.92 - - -
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: 19.00
Tm probability: 0.58
-> Orientation: N-in
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: -1.38
-> Orientation: N-in
----------------------------------------------------------------------
Structure 2
Transmembrane segments included in this structure:
Segment 1 2 3 5 6 7 8 9 10 11 12 13
Loop length 3 273 51 221 33 79 16 4 31 20 70 8 270
K+R profile 3.00 6.00 6.00 3.00 5.00 + +
+ + + 0.00 2.00 2.00
CYT-EXT prof - - - - - 0.31 0.24
-0.26 0.86 0.92 - - -
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: 19.00
Tm probability: 0.16
-> Orientation: N-in
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: -0.97
-> Orientation: N-in
----------------------------------------------------------------------
Structure 3
Transmembrane segments included in this structure:
Segment 1 2 4 5 6 7 8 9 10 11 12 13
Loop length 3 273 100 172 33 79 16 4 31 20 70 8 270
K+R profile 3.00 + 6.00 3.00 5.00 + +
+ + + 0.00 2.00 2.00
CYT-EXT prof - 0.13 - - - 0.31 0.24
-0.26 1.19 0.92 - - -
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: 13.00
Tm probability: 0.28
-> Orientation: N-in
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: -1.16
-> Orientation: N-in
----------------------------------------------------------------------
Structure 4
Transmembrane segments included in this structure:
Segment 1 5 6 7 8 9 10 11 12 13
Loop length 3 587 33 79 16 4 31 20 70 8 270
K+R profile 3.00 6.00 3.00 5.00 + +
+ + 0.00 2.00 2.00
CYT-EXT prof - - - - 0.31 0.24
0.23 0.92 - - -
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: 13.00
Tm probability: 1.00
-> Orientation: N-in
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: -0.60
-> Orientation: N-in
----------------------------------------------------------------------
Structure 5
Transmembrane segments included in this structure:
Segment 1 2 3 4 5 6 7 8 9 10 11 12 13
Loop length 3 273 51 28 172 33 79 16 4 31 20 70 8 270
K+R profile 3.00 6.00 + + 0.00 2.00 2.00
+ 6.00 6.00 3.00 5.00 + +
CYT-EXT prof - - 1.19 0.92 - - -
-0.26 - - - - 0.31 0.24
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: -7.00
Tm probability: 0.16
-> Orientation: N-out
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: 1.82
-> Orientation: N-out
----------------------------------------------------------------------
Structure 6
Transmembrane segments included in this structure:
Segment 1 4 5 6 7 8 9 10 11 12 13
Loop length 3 394 172 33 79 16 4 31 20 70 8 270
K+R profile 3.00 + + 0.00 2.00 2.00
+ 6.00 3.00 5.00 + +
CYT-EXT prof - 1.19 0.92 - - -
-0.20 - - - 0.31 0.24
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: -7.00
Tm probability: 0.99
-> Orientation: N-out
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: 1.76
-> Orientation: N-out
----------------------------------------------------------------------
Structure 7
Transmembrane segments included in this structure:
Segment 1 3 5 6 7 8 9 10 11 12 13
Loop length 3 345 221 33 79 16 4 31 20 70 8 270
K+R profile 3.00 + + 0.00 2.00 2.00
+ 6.00 3.00 5.00 + +
CYT-EXT prof - 0.86 0.92 - - -
-0.18 - - - 0.31 0.24
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: -7.00
Tm probability: 0.58
-> Orientation: N-out
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: 1.41
-> Orientation: N-out
----------------------------------------------------------------------
Structure 8
Transmembrane segments included in this structure:
Segment 1 2 5 6 7 8 9 10 11 12 13
Loop length 3 273 293 33 79 16 4 31 20 70 8 270
K+R profile 3.00 + + 0.00 2.00 2.00
+ 6.00 3.00 5.00 + +
CYT-EXT prof - 1.02 0.92 - - -
-0.26 - - - 0.31 0.24
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: -7.00
Tm probability: 0.28
-> Orientation: N-out
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: 1.65
-> Orientation: N-out
----------------------------------------------------------------------
"tem9" 1331
4 24 #t 1.24167
298 318 #f 0.7125
370 390 #f 0.833333
419 439 #f 0.995833
612 632 #t 1.22812
666 686 #t 1.30833
766 786 #t 2.17188
803 823 #t 1.68021
828 848 #t 1.31875
880 900 #t 1.82708
921 941 #t 2.22292
1012 1032 #t 1.69792
1041 1061 #t 1.83333
************************************
*TOPPREDM with prokaryotic function*
************************************
tem9.fa.___inter___ is a single sequence
Using hydrophobicity file: /bio_software/2D/toppredm/lib/Engelman-Steitz.scale
Using cyt/ext file: /bio_software/2D/toppredm/lib/Cyt-Ext.prok
Using sequence file: tem9.fa.___inter___
(1 sequences)
MRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGG
VPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGL
SLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPR
LLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQN
RSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQV
VFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCT
FITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAER
VANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAG
RWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASF
SDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQR
EDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLT
CTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSS
FHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSH
SNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAE
PVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSA
FPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHM
LLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKA
RVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNI
HNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQN
PKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPE
DGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVA
ASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGS
PVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEG
EPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGG
AAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSD
TSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPK
GGKYDDVTLMGAEVASGGCMKTGLWKSETTV
(p)rokaryotic or (e)ukaryotic: p
Charge-pair energy: 0
Length of full window (odd number!): 21
Length of core window (odd number!): 11
Number of residues to add to each end of helix: 1
Critical length: 60
Upper cutoff for candidates: 1
Lower cutoff for candidates: 0.6
Total of 8 structures are to be tested
Candidate membrane-spanning segments:
Helix Begin End Score Certainity
1 4 24 1.242 Certain
2 298 318 0.713 Putative
3 370 390 0.833 Putative
4 419 439 0.996 Putative
5 612 632 1.228 Certain
6 666 686 1.308 Certain
7 766 786 2.172 Certain
8 803 823 1.680 Certain
9 828 848 1.319 Certain
10 880 900 1.827 Certain
11 921 941 2.223 Certain
12 1012 1032 1.698 Certain
13 1041 1061 1.833 Certain
----------------------------------------------------------------------
Structure 1
Transmembrane segments included in this structure:
Segment 1 3 4 5 6 7 8 9 10 11 12 13
Loop length 3 345 28 172 33 79 16 4 31 20 70 8 270
K+R profile 2.00 6.00 6.00 3.00 5.00 + +
+ + + 0.00 2.00 2.00
CYT-EXT prof - - - - - 0.31 0.24
-0.18 1.19 0.92 - - -
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: 18.00
Tm probability: 0.58
-> Orientation: N-in
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: -1.38
-> Orientation: N-in
----------------------------------------------------------------------
Structure 2
Transmembrane segments included in this structure:
Segment 1 2 3 5 6 7 8 9 10 11 12 13
Loop length 3 273 51 221 33 79 16 4 31 20 70 8 270
K+R profile 2.00 6.00 6.00 3.00 5.00 + +
+ + + 0.00 2.00 2.00
CYT-EXT prof - - - - - 0.31 0.24
-0.26 0.86 0.92 - - -
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: 18.00
Tm probability: 0.16
-> Orientation: N-in
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: -0.97
-> Orientation: N-in
----------------------------------------------------------------------
Structure 3
Transmembrane segments included in this structure:
Segment 1 2 4 5 6 7 8 9 10 11 12 13
Loop length 3 273 100 172 33 79 16 4 31 20 70 8 270
K+R profile 2.00 + 6.00 3.00 5.00 + +
+ + + 0.00 2.00 2.00
CYT-EXT prof - 0.13 - - - 0.31 0.24
-0.26 1.19 0.92 - - -
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: 12.00
Tm probability: 0.28
-> Orientation: N-in
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: -1.16
-> Orientation: N-in
----------------------------------------------------------------------
Structure 4
Transmembrane segments included in this structure:
Segment 1 5 6 7 8 9 10 11 12 13
Loop length 3 587 33 79 16 4 31 20 70 8 270
K+R profile 2.00 6.00 3.00 5.00 + +
+ + 0.00 2.00 2.00
CYT-EXT prof - - - - 0.31 0.24
0.23 0.92 - - -
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: 12.00
Tm probability: 1.00
-> Orientation: N-in
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: -0.60
-> Orientation: N-in
----------------------------------------------------------------------
Structure 5
Transmembrane segments included in this structure:
Segment 1 2 3 4 5 6 7 8 9 10 11 12 13
Loop length 3 273 51 28 172 33 79 16 4 31 20 70 8 270
K+R profile 2.00 6.00 + + 0.00 2.00 2.00
+ 6.00 6.00 3.00 5.00 + +
CYT-EXT prof - - 1.19 0.92 - - -
-0.26 - - - - 0.31 0.24
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: -8.00
Tm probability: 0.16
-> Orientation: N-out
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: 1.82
-> Orientation: N-out
----------------------------------------------------------------------
Structure 6
Transmembrane segments included in this structure:
Segment 1 4 5 6 7 8 9 10 11 12 13
Loop length 3 394 172 33 79 16 4 31 20 70 8 270
K+R profile 2.00 + + 0.00 2.00 2.00
+ 6.00 3.00 5.00 + +
CYT-EXT prof - 1.19 0.92 - - -
-0.20 - - - 0.31 0.24
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: -8.00
Tm probability: 0.99
-> Orientation: N-out
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: 1.76
-> Orientation: N-out
----------------------------------------------------------------------
Structure 7
Transmembrane segments included in this structure:
Segment 1 3 5 6 7 8 9 10 11 12 13
Loop length 3 345 221 33 79 16 4 31 20 70 8 270
K+R profile 2.00 + + 0.00 2.00 2.00
+ 6.00 3.00 5.00 + +
CYT-EXT prof - 0.86 0.92 - - -
-0.18 - - - 0.31 0.24
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: -8.00
Tm probability: 0.58
-> Orientation: N-out
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: 1.41
-> Orientation: N-out
----------------------------------------------------------------------
Structure 8
Transmembrane segments included in this structure:
Segment 1 2 5 6 7 8 9 10 11 12 13
Loop length 3 273 293 33 79 16 4 31 20 70 8 270
K+R profile 2.00 + + 0.00 2.00 2.00
+ 6.00 3.00 5.00 + +
CYT-EXT prof - 1.02 0.92 - - -
-0.26 - - - 0.31 0.24
For CYT-EXT profile neg. values indicate cytoplasmic preference.
K+R difference: -8.00
Tm probability: 0.28
-> Orientation: N-out
Charge-difference over N-terminal Tm (+-15 residues): -1.00
(NEG-POS)/(NEG+POS): -1.0000
NEG: 0.0000
POS: 2.0000
-> Orientation: N-out
CYT-EXT difference: 1.65
-> Orientation: N-out
----------------------------------------------------------------------
"tem9" 1331
4 24 #t 1.24167
298 318 #f 0.7125
370 390 #f 0.833333
419 439 #f 0.995833
612 632 #t 1.22812
666 686 #t 1.30833
766 786 #t 2.17188
803 823 #t 1.68021
828 848 #t 1.31875
880 900 #t 1.82708
921 941 #t 2.22292
1012 1032 #t 1.69792
1041 1061 #t 1.83333
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
SAPS. Version of April 11, 1996.
Date run: Tue Jan 22 00:16:02 2002
File: /people/maria/tem9.fa.___saps___
ID gi|17511205|ref|NP_116166.6|
DE tumor endothelial marker 5 precursor [Homo sapiens]
number of residues: 1331; molecular weight: 142.0 kdal
1 MRGAPARLLL PLLPWLLLLL APEARGAPGC PLSIRSCKCS GERPKGLSGG VPGPARRRVV
61 CSGGDLPEPP EPGLLPNGTV TLLLSNNKIT GLRNGSFLGL SLLEKLDLRN NIISTVQPGA
121 FLGLGELKRL DLSNNRIGCL TSETFQGLPR LLRLNISGNI FSSLQPGVFD ELPALKVVDL
181 GTEFLTCDCH LRWLLPWAQN RSLQLSEHTL CAYPSALHAQ ALGSLQEAQL CCEGALELHT
241 HHLIPSLRQV VFQGDRLPFQ CSASYLGNDT RIRWYHNRAP VEGDEQAGIL LAESLIHDCT
301 FITSELTLSH IGVWASGEWE CTVSMAQGNA SKKVEIVVLE TSASYCPAER VANNRGDFRW
361 PRTLAGITAY QSCLQYPFTS VPLGGGAPGT RASRRCDRAG RWEPGDYSHC LYTNDITRVL
421 YTFVLMPINA SNALTLAHQL RVYTAEAASF SDMMDVVYVA QMIQKFLGYV DQIKELVEVM
481 VDMASNLMLV DEHLLWLAQR EDKACSRIVG ALERIGGAAL SPHAQHISVN ARNVALEAYL
541 IKPHSYVGLT CTAFQRREGG VPGTRPGSPG QNPPPEPEPP ADQQLRFRCT TGRPNVSLSS
601 FHIKNSVALA SIQLPPSLFS SLPAALAPPV PPDCTLQLLV FRNGRLFHSH SNTSRPGAAG
661 PGKRRGVATP VIFAGTSGCG VGNLTEPVAV SLRHWAEGAE PVAAWWSQEG PGEAGGWTSE
721 GCQLRSSQPN VSALHCQHLG NVAVLMELSA FPREVGGAGA GLHPVVYPCT ALLLLCLFAT
781 IITYILNHSS IRVSRKGWHM LLNLCFHIAM TSAVFAGGIT LTNYQMVCQA VGITLHYSSL
841 STLLWMGVKA RVLHKELTWR APPPQEGDPA LPTPSPMLRF YLIAGGIPLI ICGITAAVNI
901 HNYRDHSPYC WLVWRPSLGA FYIPVALILL ITWIYFLCAG LRLRGPLAQN PKAGNSRASL
961 EAGEELRGST RLRGSGPLLS DSGSLLATGS ARVGTPGPPE DGDSLYSPGV QLGALVTTHF
1021 LYLAMWACGA LAVSQRWLPR VVCSCLYGVA ASALGLFVFT HHCARRRDVR ASWRACCPPA
1081 SPAAPHAPPR ALPAAAEDGS PVFGEGPPSL KSSPSGSSGH PLALGPCKLT NLQLAQSQVC
1141 EAGAAAGGEG EPEPAGTRGN LAHRHPNNVH HGRRAHKSRA KGHRAGEACG KNRLKALRGG
1201 AAGALELLSS ESGSLHNSPT DSYLGSSRNS PGAGLQLEGE PMLTPSEGSD TSAAPLSEAG
1261 RAGQRRSASR DSLKGGGALE KESHRRSYPL NAASLNGAPK GGKYDDVTLM GAEVASGGCM
1321 KTGLWKSETT V
--------------------------------------------------------------------------------
COMPOSITIONAL ANALYSIS (extremes relative to: swp23s)
A :137(10.3%); C : 41( 3.1%); D : 34( 2.6%); E : 64( 4.8%); F : 32( 2.4%)
G :135(10.1%); H : 42( 3.2%); I : 43( 3.2%); K : 30( 2.3%); L :173(13.0%)
M : 19( 1.4%); N : 46( 3.5%); P :101( 7.6%); Q : 42( 3.2%); R : 87( 6.5%)
S :116( 8.7%); T : 63( 4.7%); V : 74( 5.6%); W : 23( 1.7%); Y : 29( 2.2%)
KR : 117 ( 8.8%); ED : 98 ( 7.4%); AGP : 373 ( 28.0%);
KRED : 215 ( 16.2%); KR-ED : 19 ( 1.4%); FIKMNY- : 199 ( 15.0%);
LVIFM : 341 ( 25.6%); ST : 179 ( 13.4%).
--------------------------------------------------------------------------------
CHARGE DISTRIBUTIONAL ANALYSIS
1 0+0000+000 0000000000 00-0+00000 0000+00+00 0-+0+00000 00000+++00
61 0000-00-00 -000000000 0000000+00 00+0000000 000-+0-0+0 0000000000
121 00000-0++0 -0000+0000 00-000000+ 00+0000000 000000000- -0000+00-0
181 00-0000-00 0+00000000 +00000-000 0000000000 000000-000 00-000-000
241 0000000+00 0000-+0000 00000000-0 +0+0000+00 0-0--00000 00-0000-00
301 0000-00000 0000000-0- 0000000000 0++0-0000- 00000000-+ 0000+0-0+0
361 0+00000000 0000000000 0000000000 +00++0-+00 +0-00-0000 0000-00+00
421 0000000000 0000000000 +0000-0000 0-00-00000 0000+00000 -00+-00-00
481 0-00000000 --0000000+ --+000+000 00-+000000 0000000000 0+0000-000
541 0+00000000 00000++-00 0000+00000 00000-0-00 0-000+0+00 00+0000000
601 000+000000 0000000000 0000000000 00-0000000 0+00+00000 0000+00000
661 00+++00000 0000000000 00000-0000 00+000-00- 00000000-0 00-000000-
721 0000+00000 0000000000 000000-000 00+-000000 0000000000 0000000000
781 0000000000 0+00++0000 0000000000 0000000000 0000000000 0000000000
841 00000000+0 +000+-000+ 00000-0-00 00000000+0 0000000000 0000000000
901 000+-00000 0000+00000 0000000000 0000000000 0+0+000000 0+0000+000
961 -00--0+000 +0+0000000 -000000000 0+0000000- -0-0000000 0000000000
1021 0000000000 00000+000+ 0000000000 0000000000 0000+++-0+ 000+000000
1081 000000000+ 000000--00 0000-00000 +000000000 0000000+00 0000000000
1141 -0000000-0 -0-0000+00 000+000000 00++00+0+0 +00+00-000 +0+0+00+00
1201 00000-0000 -000000000 -000000+00 0000000-0- 000000-00- 0000000-00
1261 +000++000+ -00+00000- +-00++0000 000000000+ 00+0--0000 00-0000000
1321 +0000+0-00 0
A. CHARGE CLUSTERS.
Positive charge clusters (cmin = 9/30 or 12/45 or 15/60):
1) From 1173 to 1198: RRAHKSRAKGHRAGEACGKNRLKALR
++00+0+0+00+00-000+0+0+00+
quartile: 4; size: 26, +count: 10, -count: 1, 0count: 15; t-value: 4.65 *
A: 5 (19.2%); G: 3 (11.5%); K: 4 (15.4%); R: 6 (23.1%);
Negative charge clusters (cmin = 8/30 or 11/45 or 13/60): none
Mixed charge clusters (cmin = 13/30 or 18/45 or 22/60): none
B. HIGH SCORING (UN)CHARGED SEGMENTS.
There are no high scoring positive charge segments.
There are no high scoring negative charge segments.
There are no high scoring mixed charge segments.
There are no high scoring uncharged segments.
C. CHARGE RUNS AND PATTERNS.
pattern (+)| (-)| (*)| (0)| (+0)| (-0)| (*0)|(+00)|(-00)|(*00)| (H.)|(H..)|
lmin0 5 | 4 | 6 | 57 | 10 | 9 | 12 | 12 | 12 | 15 | 8 | 10 |
lmin1 6 | 6 | 8 | 68 | 12 | 11 | 15 | 15 | 14 | 19 | 9 | 12 |
lmin2 7 | 7 | 9 | 76 | 13 | 13 | 17 | 17 | 16 | 21 | 11 | 14 |
(Significance level: 0.010000; Minimal displayed length: 6)
There are no charge runs or patterns exceeding the given minimal lengths.
Run count statistics:
+ runs >= 3: 3, at 56; 663; 1065;
- runs >= 3: 0
* runs >= 4: 2, at 500; 1065;
0 runs >= 38: 1, at 797;
--------------------------------------------------------------------------------
DISTRIBUTION OF OTHER AMINO ACID TYPES
1. HIGH SCORING SEGMENTS.
__________________________________
High scoring hydrophobic segments:
2.00 (LVIFM) 1.00 (AGYCW) 0.00 (BZX) -2.00 (PH) -4.00 (STNQ)
-8.00 (KEDR)
Expected score/letter: -1.523
M_0.01= 30.95; M_0.05= 26.05
1) From 918 to 941: length= 24, score=29.00 *
918 LGAFYIPVAL ILLITWIYFL CAGL
L: 6(25.0%); A: 3(12.5%); I: 4(16.7%);
____________________________________
High scoring transmembrane segments:
5.00 (LVIF) 2.00 (AGM) 0.00 (BZX) -1.00 (YCW) -2.00 (ST)
-6.00 (P) -8.00 (H) -10.00 (NQ) -16.00 (KR) -17.00 (ED)
Expected score/letter: -2.719
M_0.01= 74.97; M_0.05= 62.68; M_0.30= 48.07
1) From 755 to 786: length= 32, score=56.00
(pocket at 763 to 764: length= 2, score=-14.00)
755 VGGAGAGL |HP| VVYPCTALLL LCLFATIITY IL
L: 7(21.9%); A: 4(12.5%); G: 4(12.5%);
2) From 918 to 941: length= 24, score=63.00 *
918 LGAFYIPVAL ILLITWIYFL CAGL
L: 6(25.0%); A: 3(12.5%); I: 4(16.7%);
2. SPACINGS OF C.
H2N-29-C-6-C-1-C-21-C-77-C-47-C-1-C-21-C-19-C-C-28-C-37-C-21-C-24-C-26-C-22-C-13-C-94-C-45-C-37-C-44-C-44-C-42-C-13-C-32-C-6-C-28-C-22-C-63-C-17-C-27-C-89-C-14-C-1-C-17-C-12-C-C-49-C-12-C-48-C-129-C-12-COOH
2*. SPACINGS OF C and H. (additional deluxe function for ALEX)
H2N-29-C-6-C-1-C-21-C-77-C-47-C-1-C-H-17-H-2-C-6-H-12-C-C-6-H-1-H-H-18-C-14-H-20-H-1-C-10-H-10-C-24-C-26-C-22-C-12-H-C-27-H-54-H-11-C-17-H-2-H-17-H-6-C-37-C-12-H-31-C-13-H-1-H-28-C-14-H-27-C-12-H-C-1-H-24-H-5-C-6-C-11-H-10-H-5-C-1-H-20-C-7-H-17-H-37-C-8-H-4-H-3-C-27-C-80-H-8-C-14-C-1-C-15-H-H-C-12-C-C-8-H-33-H-6-C-12-C-22-H-1-H-4-H-H-4-H-6-H-5-C-26-H-67-H-34-C-12-COOH
--------------------------------------------------------------------------------
REPETITIVE STRUCTURES.
A. SEPARATED, TANDEM, AND PERIODIC REPEATS: amino acid alphabet.
Repeat core block length: 5
Aligned matching blocks:
[ 49- 53] GGVPG
[ 559- 563] GGVPG
______________________________
[ 58- 62] RVVCS
[1040-1044] RVVCS
______________________________
[ 234- 238] GALEL
[1203-1207] GALEL
B. SEPARATED AND TANDEM REPEATS: 11-letter reduced alphabet.
(i= LVIF; += KR; -= ED; s= AG; o= ST; n= NQ; a= YW; p= P; h= H; m= M; c= C)
Repeat core block length: 9
Aligned matching blocks:
[ 96- 106]-( 4)-[ 111- 122]
[ 144- 154]-( 4)-[ 159- 169]
[ 96- 106] oiisioii-+i
[ 144- 154] oinsip+ii+i
[ 111- 122] niiooinpssii
[ 159- 169] niiooinp_sii
--------------------------------------------------------------------------------
MULTIPLETS.
A. AMINO ACID ALPHABET.
1. Total number of amino acid multiplets: 103 (Expected range: 59--113)
2. Histogram of spacings between consecutive amino acid multiplets:
(1-5) 39 (6-10) 25 (11-20) 21 (>=21) 19
3. Clusters of amino acid multiplets (cmin = 13/30 or 16/45 or 20/60): none
4. Long amino acid multiplets (>= 5; Letter/Length/Position):
L/5/16
B. CHARGE ALPHABET.
1. Total number of charge multiplets: 19 (Expected range: 4-- 29)
11 +plets (f+: 8.8%), 8 -plets (f-: 7.4%)
Total number of charge altplets: 16 (Critical number: 32)
2. Histogram of spacings between consecutive charge multiplets:
(1-5) 0 (6-10) 1 (11-20) 2 (>=21) 17
--------------------------------------------------------------------------------
PERIODICITY ANALYSIS.
A. AMINO ACID ALPHABET (core: 4; !-core: 5)
Location Period Element Copies Core Errors
16- 20 1 L 5 5 ! 0
84- 187 8 L....... 11 4 2
175- 214 10 L......... 4 4 0
573- 580 2 P. 4 4 0
614- 629 4 L... 4 4 0
772- 775 1 L 4 4 0
960- 983 6 L..... 4 4 0
1071-1098 4 A... 6 4 1
1079-1090 3 P.. 4 4 0
1109-1120 3 S.. 4 4 0
1180-1211 8 A....... 4 4 0
1210-1233 4 S... 6 6 ! 0
B. CHARGE ALPHABET ({+= KR; -= ED; 0}; core: 5; !-core: 6)
and HYDROPHOBICITY ALPHABET ({*= KRED; i= LVIF; 0}; core: 6; !-core: 9)
Location Period Element Copies Core Errors
82- 141 10 i..0.....0 6 6 /0/././1/./././././2/
84- 187 8 i00....0 13 13 ! /0/2/3/././././4/
148- 187 4 i... 9 7 1
459- 542 7 i.0.... 10 6 /2/./4/././././
800- 811 2 i0 6 6 /0/1/
921- 932 2 i0 6 6 /0/2/
--------------------------------------------------------------------------------
SPACING ANALYSIS.
Location (Quartile) Spacing Rank P-value Interpretation
934-1332 (4.) I( 398)I 1 of 44 0.0000 large maximal spacing
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
Start with Pfam (from /data/patterns/pfam)
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /data/patterns/pfam/Pfam
Sequence file: tem9.fa
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
LRR Leucine Rich Repeat 66.4 5.9e-16 4
LRRCT Leucine rich repeat C-terminal domain 43.0 6.8e-09 1
GPS Latrophilin/CL-1-like GPS domain 20.8 0.0041 1
HRM Hormone receptor domain 16.3 0.0076 1
ig Immunoglobulin domain 7.8 0.77 1
chitinase_2 Chitinase, family 2 1.2 16 1
LRRNT Leucine rich repeat N-terminal domain 0.3 44 1
late_protein_L1 L1 (late) protein -0.4 32 1
CBD_7 Putative carbohydrate binding domain -10.8 30 1
ZU5 ZU5 domain -45.1 42 1
Ski_Sno SKI/SNO/DAC family -46.1 89 1
CytC_asm Cytochrome C assembly protein -52.9 22 1
7tm_2 7 transmembrane receptor (Secretin fa -56.1 0.00011 1
MgtE Divalent cation transporter -65.2 63 1
Monooxygenase Monooxygenase -68.2 28 1
CPSase_L_D3 Carbamoyl-phosphate synthetase large -93.7 53 1
DsbD Cytochrome C biogenesis protein trans -114.8 73 1
7tm_3 7 transmembrane receptor (metabotropi -172.9 42 1
xan_ur_permease Permease family -214.0 60 1
Presenilin Presenilin -280.9 62 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
LRRNT 1/1 29 72 .. 1 31 [] 0.3 44
LRR 1/4 78 101 .. 1 25 [] 15.2 1.5
LRR 2/4 102 125 .. 1 25 [] 18.3 0.18
LRR 3/4 126 149 .. 1 25 [] 26.6 0.0006
LRR 4/4 150 173 .. 1 25 [] 18.2 0.2
LRRCT 1/1 183 233 .. 1 54 [] 43.0 6.8e-09
Ski_Sno 1/1 195 302 .. 1 116 [] -46.1 89
ig 1/1 254 323 .. 1 45 [] 7.8 0.77
HRM 1/1 343 412 .. 1 79 [] 16.3 0.0076
chitinase_2 1/1 468 477 .. 310 319 .] 1.2 16
Monooxygenase 1/1 326 485 .. 1 216 [] -68.2 28
CPSase_L_D3 1/1 436 546 .. 1 128 [] -93.7 53
ZU5 1/1 606 710 .. 1 115 [] -45.1 42
CBD_7 1/1 692 717 .. 1 45 [] -10.8 30
GPS 1/1 699 751 .. 1 54 [] 20.8 0.0041
MgtE 1/1 777 901 .. 1 137 [] -65.2 63
late_protein_L1 1/1 913 924 .. 1 14 [. -0.4 32
DsbD 1/1 759 932 .. 1 226 [] -114.8 73
CytC_asm 1/1 801 1035 .. 1 242 [] -52.9 22
7tm_3 1/1 763 1051 .. 1 283 [] -172.9 42
Presenilin 1/1 748 1061 .. 1 475 [] -280.9 62
xan_ur_permease 1/1 729 1064 .. 1 443 [] -214.0 60
7tm_2 1/1 762 1069 .. 1 273 [] -56.1 0.00011
Alignments of top-scoring domains:
LRRNT: domain 1 of 1, from 29 to 72: score 0.3, E = 44
*->aCp...reCtCsp.............fglvVdCsgrgLtlevPrdlP
Cp + r+C+Cs +++++ +++ ++++ ++V Csg L e P P
gi|1751120 29 GCPlsiRSCKCSGerpkglsggvpgpARRRVVCSGGDLP-EPPE--P 72
<-*
gi|1751120 - -
LRR: domain 1 of 4, from 78 to 101: score 15.2, E = 1.5
*->nLeeLdLsnNnLsGslPpesfgnLp<-*
+L LsnN+++ +l ++sf +L+
gi|1751120 78 GTVTLLLSNNKIT-GLRNGSFLGLS 101
LRR: domain 2 of 4, from 102 to 125: score 18.3, E = 0.18
*->nLeeLdLsnNnLsGslPpesfgnLp<-*
Le LdL+nN +s ++ p++f +L
gi|1751120 102 LLEKLDLRNNIIS-TVQPGAFLGLG 125
LRR: domain 3 of 4, from 126 to 149: score 26.6, E = 0.0006
*->nLeeLdLsnNnLsGslPpesfgnLp<-*
L++LdLsnN++ l +e+f++Lp
gi|1751120 126 ELKRLDLSNNRIG-CLTSETFQGLP 149
LRR: domain 4 of 4, from 150 to 173: score 18.2, E = 0.2
*->nLeeLdLsnNnLsGslPpesfgnLp<-*
+L +L++s+N +s sl p++f Lp
gi|1751120 150 RLLRLNISGNIFS-SLQPGVFDELP 173
LRRCT: domain 1 of 1, from 183 to 233: score 43.0, E = 6.8e-09
*->NPfnCDCeLrwLlrWlretnprrledqedlrCasPeslrGqpllell
+ CDC+LrwLl W+++ r+l+ +e+++Ca+P++l+ q l +l+
gi|1751120 183 EFLTCDCHLRWLLPWAQN---RSLQLSEHTLCAYPSALHAQALGSLQ 226
psdfsCp<-*
+ + C+
gi|1751120 227 EAQLCCE 233
Ski_Sno: domain 1 of 1, from 195 to 302: score -46.1, E = 89
*->lPprpvlsgPilspsDpstnElketeLeGekiacFiVgGEkrLCLPQ
lP + s ls+ + + + L + ++ + E LC
gi|1751120 195 LPWAQNRSL-QLSEHTLCA---YPSALHAQALGSLQ---EAQLCCEG 234
alnlvLkdlVGgLhqintvldeLeIycsvC...tvdQlriLkglGilppg
al+l +l+ +L q+ d+L cs ++ +r + +
gi|1751120 235 ALELHTHHLIPSLRQVVFQGDRLPFQCSASylgNDTRIRWYHNRAPVEGD 284
vnrCgLItrtDaerLcnallta<-*
+ L+ ae L +++
gi|1751120 285 EQAGILL----AESLIHDCTFI 302
ig: domain 1 of 1, from 254 to 323: score 7.8, E = 0.77
*->GesvtLtCsvsgfgpp.p.vtWlrngk....................
G+++ ++Cs+s +++++W++n + +++++ + ++ ++
gi|1751120 254 GDRLPFQCSAS-YLGNdTrIRWYHNRApvegdeqagillaeslihdc 299
....lslti.svtpeDsgGtYtCvv<-*
+ ++ lt++ s G+ C+v
gi|1751120 300 tfitSELTLsHIGVWAS-GEWECTV 323
HRM: domain 1 of 1, from 343 to 412: score 16.3, E = 0.0076
*->glyCpatwDgi....lCWPrTpaGtlvvvpCPdyfsGfnydttgedf
+yCpa+ ++++ WPrT aG +++++C y f
gi|1751120 343 ASYCPAERVANnrgdFRWPRTLAGITAYQSCLQYP-----------F 378
s.........ngnasRnCtenGwwerhpnsnwpwpdytnCtspey<-*
++ + +++ ++ asR+C+ G+we + dy+ C +y
gi|1751120 379 TsvplgggapGTRASRRCDRAGRWE--------PGDYSHC---LY 412
chitinase_2: domain 1 of 1, from 468 to 477: score 1.2, E = 16
*->GYssaikgsV<-*
GY+++ik +V
gi|1751120 468 GYVDQIKELV 477
Monooxygenase: domain 1 of 1, from 326 to 485: score -68.2, E = 28
*->radllVGADGarStVRkllgi..fggsaarfevatlpl.vppdkeed
a + k + i ++sa + ++ +++++++
gi|1751120 326 ----------AQGNASKKVEIvvLETSASYCPAERVANnRG------ 356
ehvlpgreylgy.gpglflpvsdgrliavvnrvrvltvtlfqwptdpekw
++++ +++ +++ + + + ++++ +v+l+ +++ +
gi|1751120 357 -----DFRW--PrTLAGITAYQS------CLQYPFTSVPLGG-GAPGT-- 390
vglatvdelleefagwlpeaiglitadaeaitwlrvfpvarrladrwrkG
+ +++++ ++ g++ + ++++ ++ l++ +
gi|1751120 391 -------RASRRCDRAGRWEPGDYSHCLY-TNDITRVLYTFVLMPINASN 432
RVfLaGDAAHampPlgGQGlNlg.leDAvnLawkLaavlrgggdkaedea
++L AH +++ + ++++D+v a+ +++ l+
gi|1751120 433 ALTL----AHQLRVYTAEAASFSdMMDVVYVAQMIQKFLG---------- 468
ieelLdtYeaeRrpraervqdlar<-*
Y ++ + +e ++d+a
gi|1751120 469 -------YVDQIKELVEVMVDMAS 485
CPSase_L_D3: domain 1 of 1, from 436 to 546: score -93.7, E = 53
*->lreeLrtPtddRlfaiaeAlrrGgysVdeiheLTkIDkWFL...hKl
l +Lr+ t++ a+ + + + V + ++ I k FL+ +++
gi|1751120 436 LAHQLRVYTAE-----AASFSDM-MDVVYVAQM--IQK-FLgyvDQI 473
knIveleEkelksygldlselpaelLrkAKqlGFSDrqIAkllg......
k++ve+ + ++s+ + +++ lL A + D+ ++++g ++ +
gi|1751120 474 KELVEV-MVDMASNL--M-LVDEHLLWLAQRE---DKACSRIVGalerig 516
............vtEleVRklRkelgItPvvKqvDTcAAEFpAqTnYlYs
+ +++ ++ +v+ +V I+P+
gi|1751120 517 gaalsphaqhisVNARNVALEAYL--IKPH-------------------- 544
TY<-*
+Y
gi|1751120 545 SY 546
ZU5: domain 1 of 1, from 606 to 710: score -45.1, E = 42
*->ssflVs.....gtvdarGGrLrgsrHsGvrlIiPpr.Aipqgtrytc
s++l+s + ++ ++ ++ ++L + Pp+ + ++
gi|1751120 606 SVALASiqlppSLFSSLPAALAPPV--------PPDcTLQLLVFRNG 644
YlvvhkklstpPPlDkee...getLlSPvvecGPCDVSmSAhGalllrPV
+l ++ ++ +P +++++++++++Pv+ G S +G+ l+ PV
gi|1751120 645 RLFHSHSNTSRPGA--AGpgkRRGVATPVIFAGT---SGCGVGN-LTEPV 688
iLevpHcAslrprdkwelvllrsengg<-*
++++H A+ + + +v + +g
gi|1751120 689 AVSLRHWAE--GAE---PVAAWWSQEG 710
CBD_7: domain 1 of 1, from 692 to 717: score -10.8, E = 30
*->apaWqagtvYtgGdvVsYnGrnYkAkWWTQGeePgsssAGtwgpW<-
W++g A WW Q e Pg ++g+W
gi|1751120 692 LRHWAEG-------------AEPVAAWWSQ-EGPG-----EAGGW 717
*
gi|1751120 - -
GPS: domain 1 of 1, from 699 to 751: score 20.8, E = 0.0041
*->snpiCvfWdesel.slgvWstdrGCelvetskpshttCsCnHLTsFA
+p ++W+ + ++ g+W++ +GC+l + + C+HL++ A
gi|1751120 699 AEPVAAWWSQEGPgEAGGWTS-EGCQLRSSQP-NVSALHCQHLGNVA 743
vLmdvspn<-*
vLm +s+
gi|1751120 744 VLMELSAF 751
MgtE: domain 1 of 1, from 777 to 901: score -65.2, E = 63
*->fiPlLiGlgGNvGtqlssrlsrgLalGevsskkrvlrvlakelltsi
l +++++ + l ++s +rv+r +ll +
gi|1751120 777 ---------------LFATIITYI-LNHSS--IRVSRKGWHMLLNLC 805
llgvvlslallfvagilgggsgvideegeallflivaislliisl.vall
+ +++ s++ + +++++ +++++v+i+l ++sl+++l+
gi|1751120 806 FHIAMTSAVFAGGITLTNYQ----------MVCQAVGITLHYSSLsTLLW 845
lgvlipilfkklgl........DPdn.............vsgPlITTlaD
+gv +l k+l ++ ++++++DP+++++++ + ++PlI
gi|1751120 846 MGVKARVLHKELTWrapppqegDPALptpspmlrfyliaGGIPLI----- 890
ittlllIyllia<-*
i++++ + ++i+
gi|1751120 891 ICGIT-AAVNIH 901
late_protein_L1: domain 1 of 1, from 913 to 924: score -0.4, E = 32
*->MAlWlpsqnkvYLP<-*
+W+ps + +Y P
gi|1751120 913 --VWRPSLGAFYIP 924
DsbD: domain 1 of 1, from 759 to 932: score -114.8, E = 73
*->aFLAGLLSflSPCv....LPliPaylSyisgvslgDvkqgKGvvKPa
+AGL + PC+ L l ++ yi + ++++ +
gi|1751120 759 --GAGLHPVVYPCTalllLCLFATIITYIL--NHSSIRVS------- 794
kkvqwrvllsallFvlGftivFlllGvgaafltallrdyllylrviagvl
+++ +l + + +++++a+ ++l + + +++g+
gi|1751120 795 --------RKGWHMLLNLCFHIAMTSAVFAGGITLT--NYQMVCQAVGIT 834
vIlmGLhflgvfrgliafLrklrlvWelktkkkveisvlgafllGllFAl
+ +L++l + + + ++v +k + ++++ G
gi|1751120 835 LHYSSLSTL---LW----MGVKARV-----LHKELTWRAPPPQEG----- 867
gWtPCigPiLasvlalasstgslvllgalllvvYvLGLgiPfvlaalfag
a+ t+ +++l +Y + giP+++ ++ a+
gi|1751120 868 --------------DPALPTP------SPMLRFYLIAGGIPLIICGITAA 897
sllsflrwLrkhsraikia.....sGvLLiliGallll<-*
r hs + + +++ + + ++++ll++
gi|1751120 898 V---NIHNYRDHSPYCWLVwrpslGAFYIPVALILLIT 932
CytC_asm: domain 1 of 1, from 801 to 1035: score -52.9, E = 22
*->Wgllwfwdlvengasllpwlalgallhslslriiffavpaapillai
++ l f++ ++ a++ ++l+ ++ + i +++ ++++ll +
gi|1751120 801 LLNLCFHIAMTS-AVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWM 846
sa.......................................plvpalgsf
++ + +++ + + ++++++++ +++++ + ++ pl+++ +
gi|1751120 847 GVkarvlhkeltwrapppqegdpalptpspmlrfyliaggiPLIICGITA 896
lvrmhvlvsvhsyatldivl.glpigalftllfLvlgsgwakplwgtrwv
v h + + +y+ l v + +ga+ ++ +L+l++ w l+++
gi|1751120 897 AVNIHNYRDHSPYCWL--VWrP-SLGAFYIPVALILLITWIYFLCAGLRL 943
wdarsvkivkvsfl.N.aslftsvlrevasflylnnlllvsalivvllgt
++ +N++++ + ++ e a+ + +++
gi|1751120 944 RGPL---------AqNpKAGNSRASLE-AGEELRGST------------- 970
llpllekldnlsyrligigFpnltigiisgavWanvlawGsywsn....I
+ g+++ + + la Gs ++++
gi|1751120 971 ---R-----------------LRGSGPLLSDSGSL-LATGSARVGtpgpP 999
Wdpketwalitwlvfalfiaylhlrivkgwlgrkralvasa<-*
d +++++ + l + +h++ ++ w ++ al++s+
gi|1751120 1000 EDGDSLYSPGVQLGAL---VTTHFLYLAMWACG--ALAVSQ 1035
7tm_3: domain 1 of 1, from 763 to 1051: score -172.9, E = 42
*->lgivlvalAvlGLivltlfvlvvFvkhrdTPiVKasnreLSYlLLiG
+v+ + A+l +++ +++++++++++ ++ s + lL
gi|1751120 763 HPVVYPCTALL--LLCLFATIITYILNHSS--IRVSRKGWHMLL--- 802
lilcylcsfl.FIgkG.tv.ekPstwsCilRrilfGlgFtlcySalL...
lc+ + ++ ++ G+ + ++ + +C++ +++ l ++ ++S+lL +
gi|1751120 803 -NLCFHIAMTsAVFAGgITlTN-YQMVCQA--VGITLHYS-SLSTLLwmg 847
aKTirVl..riFrgakkpgstqkpkfispwaqvlivliltliQviicviW
+K+ ++++++ r a p ++ p + p + + li +i +iic+i
gi|1751120 848 VKARVLHkeLTWR-APPPQEG-DPALPTPSPMLRFYLIAGGIPLIICGI- 894
LvvePPrpdidiysekekeedeDvsiapiileCnkgsvvaFlvvLgYdgl
++i+ ++++ + + s aF+++ + + l
gi|1751120 895 ------TAAVNIHNYRDHSP--------YCWLVWRPSLGAFYIPVALILL 930
LavlctllAFltRnlPvdnFNEAKfItFSMYn..................
+ +l A l P + n++ ++++ + + +++ ++
gi|1751120 931 ITWIYFLCAGLRLRGP-----------LAQ-Npkagnsrasleageelrg 968
....................................vltfCiVWvAFiPa
+++ +++++ +++++ +++ + +++++++++++ +
gi|1751120 969 strlrgsgpllsdsgsllatgsarvgtpgppedgdsLY------------ 1006
YlstpgsaedykvqvaveifsilaSstvlLgclFaPKcYIILfkPekN<-
+pg+ + v++ ++ +++ a+++ + P++ + ++
gi|1751120 1007 ---SPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAA 1051
*
gi|1751120 - -
Presenilin: domain 1 of 1, from 748 to 1061: score -280.9, E = 62
*->eeelklkYg..akhvimlfvPVslCMllVvatiksvsfyeqndglkl
+ + +g+ + + + +P ++ ll ++ +
gi|1751120 748 LSAFPREVGgaGAGLHPVVYPCTALLLLCLFATI------------I 782
lYtpFhsdtptvgqklldSllNtlilIsVlvvmTf......LlvvlYkyr
+Y + hs + v+ k+++ llN +++ + mT+ +++ + Y++
gi|1751120 783 TYILNHS-SIRVSRKGWHMLLN----LCFHIAMTSavfaggITLTNYQMV 827
FYKiIhgWLilSSl..llLFlfsviyLqe.....................
+ ++ L SSl++ll ++ + L+ + + + ++++++++ +++++
gi|1751120 828 C-QAVGITLHYSSLstLLWMGVKARVLHKeltwrapppqegdpalptpsp 876
vfkaynDQDDNNQvpmdyptvllliwnFGvvGmmciHWkgpLrLqQfYLI
+++ y ++ +p+++ +i +v + +p L+
gi|1751120 877 MLRFYL-------IAGGIPLIICGITA--AVNIHNYRDHSPY----CWLV 913
tisaLmAlvfikyLPeWTaWfvLaaISvWDLVAVLtPkGPLrmLVETAqe
+L A ++i + ++L + ++ L A L +GPL Aq
gi|1751120 914 WRPSLGA-FYIPVA------LILLITWIYFLCAGLRLRGPL------AQN 950
RnepiFPAliYSStvvvltvgsnqeetnegtpsterrtskstIEYyTkRe
+S l++g ++ r +++
gi|1751120 951 PKAG-------NSR-ASLEAG---------EE--LRGSTR---------- 971
aQDDEFYQKIRQRrsaanPdsaptshstlVEAEPSpielkekssteeesd
l ++ + +
gi|1751120 972 ----------------------------L---------RGS----GPLLS 980
desdsseteGmPLvsgsSNLsssdssttvsqsdsllaphrteeiareqpe
d+++ ++t s +++ t+ + +
gi|1751120 981 DSGSLLATG-----S-------------------ARVG--TPGPPEDGDS 1004
vqsnslpsNekreeTAaDalhPdGeeErgvkLGLGDFiFYSvLvGkAsat
+ s gv LG A t
gi|1751120 1005 LY-----S-------------------PGVQLG-------------ALVT 1017
asGdwnTtIACFVaILiGLclTLlllavfkkALPALPisitfGlIFYFst
+ + AC lav+++ LP s G ++
gi|1751120 1018 THFLYLAMWAC------------GALAVSQRWLPRVVCSCLYGVA---AS 1052
dilvtPFmd<-*
+ F+
gi|1751120 1053 ALGLFVFTH 1061
xan_ur_permease: domain 1 of 1, from 729 to 1064: score -214.0, E = 60
*->gqtlllGLQhl..laMfaatvlvPllvgdalclglsaeslaylistt
+ + l +Qhl++ a + + P vg a ++gl ++ y+
gi|1751120 729 PNVSALHCQHLgnVAVLMELSAFPREVGGA-GAGL--HPVVYP---- 768
llvsGigTllQllrYgigrifGirlpivlGsSFafvtPaiglialmialG
+ ll l+ + +t +++ +
gi|1751120 769 ---CTALLLLCLF-------------------ATIIT-------YILNHS 789
sapad.qgplepigialgglfGallvagvlfilisftglrgrLarlfPPv
s +++ g ++ l f + ++v+ +i +t +
gi|1751120 790 SIRVSrKG----WHMLLNLCFHIAMTSAVFAGGITLTNYQ---------- 825
VtGpvvllIGLsLipiavkgvaggwaaildgllTllvgslellglavvvl
++ ++I L ++g++a+ l +l + + + l
gi|1751120 826 -MVCQAVGITLHYSSLSTLLWMGVKARVLHK---ELTWRAPPPQEGDPAL 871
avilllsvftavlkgffkslpiLiGiivGwilalfmGpsivdlspeGseA
+ ++ +f ++ ++i++ i++++++ + + + d+sp+
gi|1751120 872 PTPSPMLRF------YLIAGGIPLIICGITAAVNIHN--YRDHSPY---- 909
RtDkNSLavvrdapwfqlplplpfglpldalgafnpgliltmlavaivai
++++ p+++ f +p +lil+++ ++ +++
gi|1751120 910 ---------C---WLVWRPSLGAFYIP--------VALILLITWIYFLCA 939
vEsi..........GditatakvsgrdlkpgtykprlrRg..lladGlat
++++ ++++ G +a + + l + ++rlr++++ll d+ +
gi|1751120 940 GLRLrgplaqnpkaGNSRASLEAGE-ELRG---STRLRGSgpLLSDSGSL 985
llaGlfGagtPt......TtfaeNiGvvalTrvaSrrvgvtaavilillG
l +G +gtP +++++++ +++ +v+l+ + vt+ +++
gi|1751120 986 LATGSARVGTPGppedgdSLYSP---GVQLG------ALVTTHFLYLAMW 1026
lfpKfaallssIPspVlGGvmlvlFgmiagsGvsilqsvdldysaRnllI
++++a +P V +s+ +
gi|1751120 1027 ACGALAVSQRWLPRVV--------------------CSCLYG-------- 1048
iavSlvlGlgiptvpei<-*
+a+S +lGl+++t++
gi|1751120 1049 VAAS-ALGLFVFTHHCA 1064
7tm_2: domain 1 of 1, from 762 to 1069: score -56.1, E = 0.00011
*->allLkviytVGyslSsLvcLllaiaifllfR.kLrctRnyIHm..NL
++ + + t +l L cL +i+++ l +++r R Hm NL
gi|1751120 762 LHPVVYPCT---ALL-LLCLFATIITYILNHsSIRVSRKGWHMllNL 804
flsfiLralsfLigdavllnsg.CkvvavflhYfflaNFfWmLvEGlYLy
+ + + +++f g++ + +++ C +v + lhY l++ Wm+v + L+
gi|1751120 805 CFHIAMTSAVFAGGITLTNYQMvCQAVGITLHYSSLSTLLWMGVKARVLH 854
tLlvvtv.........evffserkrlwwYlliGWGvPavfvtiwaivrpd
l + + ++++++ + + ++ ++ ++li G+P+++ +i a+v
gi|1751120 855 KEL---TwrapppqegDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIH 901
kygpilaegpagygnegcCWlsndtnsgfwWiikGPilliilvNfiffin
+ + ++ +CWl +++ g ++i P++li+l+ i f++
gi|1751120 902 N----------YRDHSPYCWLVWRPSLGAFYI---PVALILLITWIYFLC 938
ilriLvqKlridslspqtgetdqyrk........................
+ L l +p +g + + +++ +++++ +++++ +++++
gi|1751120 939 AGLRLRGPLA---QNPKAGNSRASLEageelrgstrlrgsgpllsdsgsl 985
...........................krlvkstLlLlPLLGvtwilflf
+++ + +++++++++++ +++ + +lv + +l l w +++
gi|1751120 986 latgsarvgtpgppedgdslyspgvqlGALVTTHFLYL----AMWACGAL 1031
apedqsqGtlslvflylfliLnSfQGffVavlYCflNgEV<-*
a++ + + ++v l + S G+fV+ +C +++V
gi|1751120 1032 AVSQRW--LPRVVCSCLYGVAASALGLFVFTHHCARRRDV 1069
//
Start with PfamFrag (from /data/patterns/pfam)
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /data/patterns/pfam/PfamFrag
Sequence file: tem9.fa
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
LRR Leucine Rich Repeat 54.8 6e-13 5
LRRCT Leucine rich repeat C-terminal domain 41.1 1.9e-12 1
GPS Latrophilin/CL-1-like GPS domain 18.9 0.0012 1
HRM Hormone receptor domain 17.1 0.005 1
ig Immunoglobulin domain 7.8 0.77 1
7tm_2 7 transmembrane receptor (Secretin fa 7.5 0.21 2
DUF190 Uncharacterized ACR, COG1993 5.8 3.6 1
CBD_7 Putative carbohydrate binding domain 5.5 9.6 1
HAMP HAMP domain 3.5 22 1
BAG BAG domain 2.9 25 1
chitinase_2 Chitinase, family 2 1.2 16 1
Mtap_PNP Phosphorylase family 2 0.2 41 1
Methyltransf_3 O-methyltransferase -0.2 67 1
UPF0060 Uncharacterized BCR, YnfA/UPF0060 fam -0.4 52 1
late_protein_L1 L1 (late) protein -0.4 32 1
DUF243 Domain of unknown function (DUF243) -1.1 80 1
prion Prion protein -1.1 58 1
TT_ORF1 TT viral orf 1 -1.5 68 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
LRR 1/5 78 101 .. 1 25 [] 13.3 0.12
LRR 2/5 102 125 .. 1 25 [] 16.4 0.018
LRR 3/5 126 149 .. 1 25 [] 24.6 0.0001
LRR 4/5 150 173 .. 1 25 [] 16.3 0.019
LRRCT 1/1 183 233 .. 1 54 [] 41.1 1.9e-12
ig 1/1 254 323 .. 1 45 [] 7.8 0.77
HRM 1/1 360 412 .. 14 79 .] 17.1 0.005
DUF190 1/1 435 450 .. 1 16 [. 5.8 3.6
BAG 1/1 459 474 .. 76 91 .] 2.9 25
chitinase_2 1/1 468 477 .. 310 319 .] 1.2 16
LRR 5/5 613 623 .. 15 25 .] 0.4 4.1e+02
CBD_7 1/1 703 717 .. 25 45 .] 5.5 9.6
Mtap_PNP 1/1 734 744 .. 271 281 .] 0.2 41
GPS 1/1 699 751 .. 1 54 [] 18.9 0.0012
Methyltransf_3 1/1 746 754 .. 1 9 [. -0.2 67
7tm_2 1/2 818 848 .. 58 87 .. 5.7 0.7
TT_ORF1 1/1 883 907 .. 95 117 .. -1.5 68
late_protein_L1 1/1 913 924 .. 1 14 [. -0.4 32
prion 1/1 928 940 .. 232 244 .] -1.1 58
UPF0060 1/1 929 941 .. 1 13 [. -0.4 52
HAMP 1/1 921 949 .. 1 29 [. 3.5 22
DUF243 1/1 1001 1020 .. 1 20 [. -1.1 80
7tm_2 2/2 1055 1069 .. 259 273 .] 1.9 9.8
Alignments of top-scoring domains:
LRR: domain 1 of 5, from 78 to 101: score 13.3, E = 0.12
*->nLeeLdLsnNnLsGslPpesfgnLp<-*
+L LsnN+++ +l ++sf +L+
gi|1751120 78 GTVTLLLSNNKIT-GLRNGSFLGLS 101
LRR: domain 2 of 5, from 102 to 125: score 16.4, E = 0.018
*->nLeeLdLsnNnLsGslPpesfgnLp<-*
Le LdL+nN +s ++ p++f +L
gi|1751120 102 LLEKLDLRNNIIS-TVQPGAFLGLG 125
LRR: domain 3 of 5, from 126 to 149: score 24.6, E = 0.0001
*->nLeeLdLsnNnLsGslPpesfgnLp<-*
L++LdLsnN++ l +e+f++Lp
gi|1751120 126 ELKRLDLSNNRIG-CLTSETFQGLP 149
LRR: domain 4 of 5, from 150 to 173: score 16.3, E = 0.019
*->nLeeLdLsnNnLsGslPpesfgnLp<-*
+L +L++s+N +s sl p++f Lp
gi|1751120 150 RLLRLNISGNIFS-SLQPGVFDELP 173
LRRCT: domain 1 of 1, from 183 to 233: score 41.1, E = 1.9e-12
*->NPfnCDCeLrwLlrWlretnprrledqedlrCasPeslrGqpllell
+ CDC+LrwLl W+++ r+l+ +e+++Ca+P++l+ q l +l+
gi|1751120 183 EFLTCDCHLRWLLPWAQN---RSLQLSEHTLCAYPSALHAQALGSLQ 226
psdfsCp<-*
+ + C+
gi|1751120 227 EAQLCCE 233
ig: domain 1 of 1, from 254 to 323: score 7.8, E = 0.77
*->GesvtLtCsvsgfgpp.p.vtWlrngk....................
G+++ ++Cs+s +++++W++n + +++++ + ++ ++
gi|1751120 254 GDRLPFQCSAS-YLGNdTrIRWYHNRApvegdeqagillaeslihdc 299
....lslti.svtpeDsgGtYtCvv<-*
+ ++ lt++ s G+ C+v
gi|1751120 300 tfitSELTLsHIGVWAS-GEWECTV 323
HRM: domain 1 of 1, from 360 to 412: score 17.1, E = 0.005
*->WPrTpaGtlvvvpCPdyfsGfnydttgedfs.........ngnasRn
WPrT aG +++++C y f++ + +++ ++ asR+
gi|1751120 360 WPRTLAGITAYQSCLQYP-----------FTsvplgggapGTRASRR 395
CtenGwwerhpnsnwpwpdytnCtspey<-*
C+ G+we + dy+ C +y
gi|1751120 396 CDRAGRWE--------PGDYSHC---LY 412
DUF190: domain 1 of 1, from 435 to 450: score 5.8, E = 3.6
*->vkkklLrIYtsEddkf<-*
+++ Lr+Yt+E+ +f
gi|1751120 435 TLAHQLRVYTAEAASF 450
BAG: domain 1 of 1, from 459 to 474: score 2.9, E = 25
*->lvrkiqalLeklDskk<-*
+++ iq++L ++D++k
gi|1751120 459 VAQMIQKFLGYVDQIK 474
chitinase_2: domain 1 of 1, from 468 to 477: score 1.2, E = 16
*->GYssaikgsV<-*
GY+++ik +V
gi|1751120 468 GYVDQIKELV 477
LRR: domain 5 of 5, from 613 to 623: score 0.4, E = 4.1e+02
*->slPpesfgnLp<-*
+lPp++f++Lp
gi|1751120 613 QLPPSLFSSLP 623
CBD_7: domain 1 of 1, from 703 to 717: score 5.5, E = 9.6
*->AkWWTQGeePgsssAGtwgpW<-*
A WW Q e Pg ++g+W
gi|1751120 703 AAWWSQ-EGPG-----EAGGW 717
Mtap_PNP: domain 1 of 1, from 734 to 744: score 0.2, E = 41
*->licaillriAv<-*
l+c++l ++Av
gi|1751120 734 LHCQHLGNVAV 744
GPS: domain 1 of 1, from 699 to 751: score 18.9, E = 0.0012
*->snpiCvfWdesel.slgvWstdrGCelvetskpshttCsCnHLTsFA
+p ++W+ + ++ g+W++ +GC+l + + C+HL++ A
gi|1751120 699 AEPVAAWWSQEGPgEAGGWTS-EGCQLRSSQP-NVSALHCQHLGNVA 743
vLmdvspn<-*
vLm +s+
gi|1751120 744 VLMELSAF 751
Methyltransf_3: domain 1 of 1, from 746 to 754: score -0.2, E = 67
*->retSvyPRe<-*
+e S++PRe
gi|1751120 746 MELSAFPRE 754
7tm_2: domain 1 of 2, from 818 to 848: score 5.7, E = 0.7
*->gdavllnsg.CkvvavflhYfflaNFfWmLv<-*
g++ + +++ C +v + lhY l++ Wm+v
gi|1751120 818 GITLTNYQMvCQAVGITLHYSSLSTLLWMGV 848
TT_ORF1: domain 1 of 1, from 883 to 907: score -1.5, E = 68
*->IkGyLPiliCGentv..nrNYalHs<-*
I G+ P++iCG + + +++NY Hs
gi|1751120 883 IAGGIPLIICGITAAvnIHNYRDHS 907
late_protein_L1: domain 1 of 1, from 913 to 924: score -0.4, E = 32
*->MAlWlpsqnkvYLP<-*
+W+ps + +Y P
gi|1751120 913 --VWRPSLGAFYIP 924
prion: domain 1 of 1, from 928 to 940: score -1.1, E = 58
*->iLLisFLiflivG<-*
iLLi ++ fl G
gi|1751120 928 ILLITWIYFLCAG 940
UPF0060: domain 1 of 1, from 929 to 941: score -0.4, E = 52
*->mlrtiLLFvaAaL<-*
l+t +F+ A+L
gi|1751120 929 LLITWIYFLCAGL 941
HAMP: domain 1 of 1, from 921 to 949: score 3.5, E = 22
*->lvlvlllalllllllvlllarrllrPlrk<-*
+++ ++l+ll+ + +l++ rl+ Pl +
gi|1751120 921 FYIPVALILLITWIYFLCAGLRLRGPLAQ 949
DUF243: domain 1 of 1, from 1001 to 1020: score -1.1, E = 80
*->qqaaqqgqraqqaaevhKeF<-*
+ +++++++q a+v+++F
gi|1751120 1001 DGDSLYSPGVQLGALVTTHF 1020
7tm_2: domain 2 of 2, from 1055 to 1069: score 1.9, E = 9.8
*->GffVavlYCflNgEV<-*
G+fV+ +C +++V
gi|1751120 1055 GLFVFTHHCARRRDV 1069
//
Start with Repeat Library (from /data/patterns/repeats-Miguel-Andrade/hmm)
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /data/patterns/repeats-Miguel-Andrade/hmm/repeats.hmm-lib
Sequence file: tem9.fa
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
LRR-ma 23.8 0.0039 3
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
LRR-ma 1/3 100 113 .. 1 14 [] 8.0 84
LRR-ma 2/3 124 137 .. 1 14 [] 15.0 1.8
LRR-ma 3/3 148 161 .. 1 14 [] 8.5 68
Alignments of top-scoring domains:
LRR-ma: domain 1 of 3, from 100 to 113: score 8.0, E = 84
*->lpsLeeLdLsnNrl<-*
l+ Le+LdL+nN +
gi|1751120 100 LSLLEKLDLRNNII 113
LRR-ma: domain 2 of 3, from 124 to 137: score 15.0, E = 1.8
*->lpsLeeLdLsnNrl<-*
l L++LdLsnNr+
gi|1751120 124 LGELKRLDLSNNRI 137
LRR-ma: domain 3 of 3, from 148 to 161: score 8.5, E = 68
*->lpsLeeLdLsnNrl<-*
lp+L +L++s+N +
gi|1751120 148 LPRLLRLNISGNIF 161
//
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
Start with Prosite
---------------------------------------------------------
| ppsearch (c) 1994 EMBL Data Library |
| based on MacPattern (c) 1990-1994 R. Fuchs |
---------------------------------------------------------
PROSITE pattern search started: Tue Jan 22 00:19:53 2002
Sequence file: tem9.fa
----------------------------------------
Sequence gi|17511205|ref|NP_116166.6| (1331 residues):
Matching pattern PS00001 ASN_GLYCOSYLATION:
77: NGTV
94: NGSF
155: NISG
200: NRSL
268: NDTR
329: NASK
429: NASN
595: NVSL
652: NTSR
683: NLTE
730: NVSA
787: NHSS
Total matches: 12
Matching pattern PS00005 PKC_PHOSPHO_SITE:
33: SIR
36: SCK
246: SLR
331: SKK
393: SRR
591: TGR
653: TSR
691: SLR
790: SIR
794: SRK
858: TWR
969: STR
990: SAR
1034: SQR
1072: SWR
1109: SLK
1226: SSR
1272: SLK
1283: SHR
Total matches: 19
Matching pattern PS00006 CK2_PHOSPHO_SITE:
62: SGGD
101: SLLE
224: SLQE
449: SFSD
1218: SPTD
1244: TPSE
Total matches: 6
Matching pattern PS00008 MYRISTYL:
29: GCPLSI
46: GLSGGV
73: GLLPNG
91: GLRNGS
95: GSFLGL
119: GAFLGL
138: GCLTSE
158: GNIFSS
288: GILLAE
312: GVWASG
385: GGAPGT
386: GAPGTR
389: GTRASR
548: GLTCTA
559: GGVPGT
560: GVPGTR
563: GTRPGS
675: GTSGCG
678: GCGVGN
715: GGWTSE
756: GGAGAG
757: GAGAGL
818: GITLTN
893: GITAAV
954: GNSRAS
983: GSLLAT
1009: GVQLGA
1013: GALVTT
1048: GVAASA
1143: GAAAGG
1156: GTRGNL
1199: GGAAGA
1200: GAAGAL
1213: GSLHNS
1225: GSSRNS
1248: GSDTSA
1263: GQRRSA
1297: GAPKGG
1311: GAEVAS
1318: GCMKTG
1323: GLWKSE
Total matches: 41
Matching pattern PS00009 AMIDATION:
661: PGKR
1171: HGRR
Total matches: 2
Matching pattern PS00016 RGD:
355: RGD
Total matches: 1
Total no of hits in this sequence: 81
========================================
1314 pattern(s) searched in 1 sequence(s), 1331 residues.
Total no of hits in all sequences: 81.
Search time: 00:00 min
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
Start with Profile Search
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
Start with motif search against own library
***** bioMotif : Version V41a DB, 1999 Nov 11 *****
SeqTyp=2 : PROTEIN search;
>APC D-Box is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>ER-GOLGI-traffic signal is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>INTRA-SIGNAL-M minimal SH3 binding is the MOTIF name
>gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens] ;LENGTH=1331; DIRECT_SEQUENCE
n 14 solutions
m %_PXXP 11-14
f
m %_PXXP 28-31
f
m %_PXXP 67-70
f
m %_PXXP 69-72
f
m %_PXXP 566-569
f
m %_PXXP 574-577
f
m %_PXXP 577-580
f
m %_PXXP 628-631
f
m %_PXXP 629-632
f
m %_PXXP 869-872
f
m %_PXXP 996-999
f
m %_PXXP 1079-1082
f
m %_PXXP 1082-1085
f
m %_PXXP 1085-1088
f
>STATISTICS Total : 14 solutions in 1 sequences, 1331 units; out of 1 sequences, 1331 units
>INTRA-SIGNAL-M deubiquitinating enzyme SH3 domain binding motif (Kato, 2000) is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>INTRA-SIGNAL-M minimal class I consensus-SH3 binding motif is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>INTRA-SIGNAL-M minimal class II consensus-SH3 binding motif is the MOTIF name
>gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens] ;LENGTH=1331; DIRECT_SEQUENCE
n 1 solutions
m %_XPXXPXR 1084-1090
f
>STATISTICS Total : 1 solutions in 1 sequences, 1331 units; out of 1 sequences, 1331 units
>INTRA-SIGNAL-M exact 14-3-3 binding consensus (Muslin 1996 Cell 84 889) is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>INTRA-SIGNAL-M 14-3-3 binding motif in RAF and others (Muslin 1996 Cell 84 889) is the MOTIF name
>gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens] ;LENGTH=1331; DIRECT_SEQUENCE
n 1 solutions
m %_RSXXP 725-729
f
>STATISTICS Total : 1 solutions in 1 sequences, 1331 units; out of 1 sequences, 1331 units
>INTRA-SIGNAL-M WW domain binding motif in formins (Bedford 1997) is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>INTRA-SIGNAL-M PY motif for WW domain is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>TM-CYTOPLASMIC-M di-hydrophobic endocytosis motifs for internalized transmembrane proteins is the MOTIF name
>gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens] ;LENGTH=1331; DIRECT_SEQUENCE
n 1 solutions
m %_D 981-981 %_XXXL 982-985 %_L 986-986
f
>STATISTICS Total : 1 solutions in 1 sequences, 1331 units; out of 1 sequences, 1331 units
>TM-CYTOPLASMIC-M tyrosine-based endocytosis motif for internalized transmembrane proteins is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>TM-EXTRACELL-M Endocytosis signal for internalized transmembrane proteins is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>EXTRACELL-M minimal furin protease cleavage site motif is the MOTIF name
>gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens] ;LENGTH=1331; DIRECT_SEQUENCE
n 8 solutions
m %_RXXR 150-153
f
m %_RXXR 359-362
f
m %_RXXR 391-394
f
m %_RXXR 395-398
f
m %_RXXR 398-401
f
m %_RXXR 642-645
f
m %_RXXR 792-795
f
m %_RXXR 1067-1070
f
>STATISTICS Total : 8 solutions in 1 sequences, 1331 units; out of 1 sequences, 1331 units
>EXTRACELL-M extended furin protease cleavage site motif is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>EXTRACELL-M zinc binding motif in MMPs is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>EXTRACELL-M g alpha binding go loco is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS PDX-1 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS QKI-5 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS HCDA experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS SV40 LrgT experimentally determined is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS H2B experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS v-Rel experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Amida experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Amida experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS RanBP3 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Pho4p experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS DNAhelicaseQ1 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS LEF-1 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS TCF-1 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR p53-NLS1 NLS experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS hum-Ku70 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS GAL4 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS act/inh betaA experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS BDV-P experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS BDV-P experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS BDV-P experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS TR2 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS THOV NP experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS polyomaVP1 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS HIV-1 Tat experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS HIV-1 Rev experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Rex experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS SRY experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS SRY experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS SOX9 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS SOX9 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS NS5A experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS DNAse EBV experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS DNAse EBV experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS adenovE1a experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS ystDNApolalpha experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS hVDR experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS CPV capsid experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS hGlu.cort.experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS cFOS experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS cJUN experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS hDNApolalpha experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS hDNAtopoII experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS hDNAtopoII experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS hBLM experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS hARNT experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS influenzaNP experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS influenzaNP experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS p54 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS hProTalpha experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Tst1/Oct6 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS protHsc9 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS protHsci experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS protHsc3 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Ta alpha experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Pax-QNR experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Hunt.Dis.pro experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS MyoD experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS MyoD experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS opaque2 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS CTP experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS HCV experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS HCV experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS p110RB1 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS VirD2-Nterm experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS VirD2-Cterm experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Nucloplasmin experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Nucleolin experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS ICP-8 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Nab2 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS M9 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS lscMyc experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS humKprotein experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS FluA experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Mat-alpha experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS polyoma Lrg-T experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS polyoma Lrg-T experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS SV40 VP1 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS SV40 VP2 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS polyoma VP2 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS c-myb experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS N-myc experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS p53 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS c-erb-A experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS yeast SKI3 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS L29 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS L29 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS Max experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS L3 experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>NUCLEAR NLS dyskerin experimentally determined NLS is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>PDZ domain binding motif science 278_2075_pawson is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
>WW domain binding motif science 278_2075_pawson is the MOTIF name
>STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1331 units
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~ ~~~
Start with HMM-search search against own library
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /data/patterns/own/own-hmm.lib
Sequence file: tem9.fa
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
[no hits above thresholds]
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
[no hits above thresholds]
Alignments of top-scoring domains:
[no hits above thresholds]
//
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /data/patterns/own/own-hmm-f.lib
Sequence file: tem9.fa
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
[no hits above thresholds]
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
[no hits above thresholds]
Alignments of top-scoring domains:
[no hits above thresholds]
//
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
L. Aravind's signalling DB+ PSSM from other authors
IMPALA version 1.1 [20-December-1999]
Reference: Alejandro A. Schaffer, Yuri I. Wolf, Chris P. Ponting,
Eugene V. Koonin, L. Aravind, Stephen F. Altschul (1999),
"IMPALA: Matching a Protein Sequence Against a Collection of
"PSI-BLAST-Constructed Position-Specific Score Matrices",
Bioinformatics 15:1000-1011.
Query= gi|17511205|ref|NP_116166.6| tumor endothelial marker 5
precursor [Homo sapiens]
(1400 letters)
Searching..................................done
Results from profile search
Score E
Sequences producing significant alignments: (bits) Value
LRR Leucine rich repeats 79 5e-17
PUM Pumilio repeat RNA binding domain 25 0.58
14-3-3 14-3-3 protein alpha Helical domain 24 1.2
PDE cyclic NMP phosphodiesterase domain 24 1.5
DHHC Novel zinc finger domain with DHHC signature 22 5.5
HOG HOG- intein(HINT) like domain 22 5.7
FYVE Zinc Finger domain involved in PtdIns(3)P binding 22 6.1
ARM Armadillo repeat 22 6.4
SH2 Src Homology domain 2 22 6.6
CALC Calcineurin like Phosphoesterase domain 22 7.1
KIN Protein kinase domain 22 7.3
MIZFIN MIZ type Cysteine zinc DNA binding domain 22 7.5
>LRR Leucine rich repeats
Length = 339
Score = 78.7 bits (192), Expect = 5e-17
Identities = 37/149 (24%), Positives = 37/149 (24%), Gaps = 3/149 (2%)
Query: 69 PPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELK 128
Sbjct: 26 PTDIFRMKDLTI-IDLSRNQLREVPT-NLEYAKGSIVLNLSYNNIETIPNSVCANLIDLL 83
Query: 129 RLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCD 188
Sbjct: 84 FLDLSNNKLDMLPPQ-IRRLSMLQSLKLSNNPLNHFQLKQLPSMTSLSVLHMSNTNRTLD 142
Query: 189 CHLRWLLPWAQNRSLQLSEHTLCAYPSAL 217
Sbjct: 143 NIPPTLDDMHNLRDVDFSENNLPIVPEAL 171
Score = 72.9 bits (177), Expect = 2e-15
Identities = 37/155 (23%), Positives = 37/155 (23%), Gaps = 10/155 (6%)
Query: 57 RRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTV 116
Sbjct: 178 RKLNLSGNKIEKLNMTEGEWENLETLNMSHNQLTVLPD-CVVKLTRLTKLYAANNQLTFE 236
Query: 117 Q-PGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 175
Sbjct: 237 GIPSGIGKLIQLTVLHLSYNKLELVP-EGISRCVKLQKLKLDHNRLITL-PEGIHLLPDL 294
Query: 176 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTL 210
Sbjct: 295 KVLDLH------ENENLVMPPKPNDARKKLAFYNI 323
Score = 25.4 bits (55), Expect = 0.46
Identities = 6/22 (27%), Positives = 6/22 (27%)
Query: 94 NGSFLGLSLLEKLDLRNNIIST 115
Sbjct: 1 HGELSDLPRLRSVIVRDNNLKT 22
Score = 23.4 bits (50), Expect = 1.9
Identities = 4/19 (21%), Positives = 4/19 (21%)
Query: 119 GAFLGLGELKRLDLSNNRI 137
Sbjct: 2 GELSDLPRLRSVIVRDNNL 20
Score = 22.6 bits (48), Expect = 3.7
Identities = 5/19 (26%), Positives = 5/19 (26%)
Query: 145 FQGLPRLLRLNISGNIFSS 163
Sbjct: 4 LSDLPRLRSVIVRDNNLKT 22
>PUM Pumilio repeat RNA binding domain
Length = 337
Score = 25.2 bits (55), Expect = 0.58
Identities = 11/73 (15%), Positives = 11/73 (15%), Gaps = 8/73 (10%)
Query: 442 VYTAEAASFSDMMDVVYVAQMIQKFLGYV--DQIKELVEVMVDMASNL--MLVDEHLLWL 497
Sbjct: 44 MYEQIKPFFLDLILDPFGNYLVQKLCDYLTAEQKTLLIQT---IYPNVFQISINQYGTRS 100
Query: 498 AQRE-DKACSRIV 509
Sbjct: 101 LQKIIDTVDNEVQ 113
Score = 22.5 bits (48), Expect = 4.3
Identities = 10/51 (19%), Positives = 10/51 (19%), Gaps = 9/51 (17%)
Query: 122 LGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDEL 172
Sbjct: 7 LPLRDLDYIKLATDQFGC------RFLQKKLETPSESNMVRDL---MYEQI 48
>14-3-3 14-3-3 protein alpha Helical domain
Length = 270
Score = 24.2 bits (52), Expect = 1.2
Identities = 8/21 (38%), Positives = 8/21 (38%)
Query: 226 QEAQLCCEGALELHTHHLIPS 246
Sbjct: 93 QELDTICQDILTVLEKHLIPN 113
>PDE cyclic NMP phosphodiesterase domain
Length = 350
Score = 24.0 bits (51), Expect = 1.5
Identities = 11/29 (37%), Positives = 11/29 (37%), Gaps = 1/29 (3%)
Query: 407 YSHCLYTNDITRVLYTFVLMPINASNALT 435
Sbjct: 66 YHNFTHAFDVTQTVYTF-LTSFNAAQYLT 93
>DHHC Novel zinc finger domain with DHHC signature
Length = 217
Score = 22.0 bits (46), Expect = 5.5
Identities = 5/52 (9%), Positives = 5/52 (9%), Gaps = 5/52 (9%)
Query: 761 GLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTS 812
Sbjct: 50 PLQIVAWLLYLFFAVIGFGILVPLLPHHWVP-----AGYACMGAIFAGHLVV 96
>HOG HOG- intein(HINT) like domain
Length = 389
Score = 21.9 bits (46), Expect = 5.7
Identities = 8/46 (17%), Positives = 8/46 (17%)
Query: 471 DQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIG 516
Sbjct: 225 EQMQNFVQLHTDGGAVLTVTPAHLVSVWQPESQKLTFVFAHRIEEK 270
>FYVE Zinc Finger domain involved in PtdIns(3)P binding
Length = 99
Score = 22.0 bits (46), Expect = 6.1
Identities = 12/61 (19%), Positives = 12/61 (19%), Gaps = 14/61 (22%)
Query: 696 AEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQP---NVSAL-----------HCQHLGN 741
Sbjct: 6 ADEHGKLMCWDMNCKRVETPEWKTSDCCQKCNQPFFWNLQAMWQRKVVGLRQHHCRTCGS 65
Query: 742 V 742
Sbjct: 66 A 66
>ARM Armadillo repeat
Length = 532
Score = 21.8 bits (46), Expect = 6.4
Identities = 15/89 (16%), Positives = 15/89 (16%), Gaps = 5/89 (5%)
Query: 244 IPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGIL--LAESLIHDCTF 301
Sbjct: 74 LKDMVAGVWSDD-PALQLES--TTQFRKLLSIERSPPIEEVISAGVVPRFVEFLKKEDYP 130
Query: 302 ITSELTLSHIGVWASGEWECTVSMAQGNA 330
Sbjct: 131 AIQFEAAWALTNIASGTSDHTKVVIDHNA 159
>SH2 Src Homology domain 2
Length = 119
Score = 21.7 bits (46), Expect = 6.6
Identities = 5/26 (19%), Positives = 5/26 (19%), Gaps = 3/26 (11%)
Query: 73 GLLPNGTVTLLLSNNKITGLRNGSFL 98
Sbjct: 10 KDITRKDAERQLLAP---GNSAGAFL 32
>CALC Calcineurin like Phosphoesterase domain
Length = 274
Score = 21.7 bits (45), Expect = 7.1
Identities = 14/135 (10%), Positives = 14/135 (10%), Gaps = 18/135 (13%)
Query: 770 TALLLLCLFATIITYIL--NHSS---IRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNY 824
Sbjct: 74 IRFVEMMKPFNKPVFWIPGNHDFQPKMAEFLNQPPMNAAKHLLLGEHWQALL----LDSQ 129
Query: 825 QMVCQAVGITLHYSSLSTLLWMGVKAR------VLHKELTWRAPPPQEGDPALPTPSPML 878
Sbjct: 130 VYGV--PHGQLSQHQLDLLKETLGKNPERYTLVVLHHHLLPTNSAWLDQHNLRNSHELAE 187
Query: 879 RFYLIAGGIPLIICG 893
Sbjct: 188 VL-APFTNVKAILYG 201
>KIN Protein kinase domain
Length = 313
Score = 21.6 bits (45), Expect = 7.3
Identities = 14/121 (11%), Positives = 14/121 (11%), Gaps = 11/121 (9%)
Query: 463 IQKFLGYV-----DQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSR-IVGALERIG 516
Sbjct: 90 LISIKDILKPNSKEQFEDVYIVSELMDTDLHQIITSPQPLSDDHCQYFVYQMLRGLKHIH 149
Query: 517 GAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPE 576
Sbjct: 150 ----SANVLHRDLKPSNLLINEDCLLKICDLGL-ARVEDATHQGFMTEYVATRWYRAPEV 204
Query: 577 P 577
Sbjct: 205 I 205
>MIZFIN MIZ type Cysteine zinc DNA binding domain
Length = 172
Score = 21.5 bits (45), Expect = 7.5
Identities = 7/29 (24%), Positives = 7/29 (24%)
Query: 316 SGEWECTVSMAQGNASKKVEIVVLETSAS 344
Sbjct: 114 VFSKPCSVTVASDASKKKIDVIDLTIESS 142
Underlying Matrix: BLOSUM62
Number of sequences tested against query: 105
Number of sequences better than 10.0: 12
Number of calls to ALIGN: 17
Length of query: 1400
Total length of test sequences: 20182
Effective length of test sequences: 16435.0
Effective search space size: 22418435.7
Initial X dropoff for ALIGN: 25.0 bits
Y. Wolf's SCOP PSSM
IMPALA version 1.1 [20-December-1999]
Reference: Alejandro A. Schaffer, Yuri I. Wolf, Chris P. Ponting,
Eugene V. Koonin, L. Aravind, Stephen F. Altschul (1999),
"IMPALA: Matching a Protein Sequence Against a Collection of
"PSI-BLAST-Constructed Position-Specific Score Matrices",
Bioinformatics 15:1000-1011.
Query= gi|17511205|ref|NP_116166.6| tumor endothelial marker 5
precursor [Homo sapiens]
(1400 letters)
Searching.................................................done
Results from profile search
Score E
Sequences producing significant alignments: (bits) Value
gi|1881738 [246..599] Leucine-rich repeats 74 1e-14
gi|132575 [1..456] Leucine-rich repeats 71 1e-13
gi|1082610 [223..548] Leucine-rich repeats 66 4e-12
gi|1418519 [191..423] Leucine-rich repeats 65 6e-12
gi|2623618 [35..332] Leucine-rich repeats 65 1e-11
gi|1652821 [74..598] Periplasmic binding protein-like II 31 0.10
gi|485157 [209..476] Protein kinases (PK), catalytic core 28 0.79
gi|2499672 [624..853] Protein kinases (PK), catalytic core 27 1.8
gi|1536958 [63..316] Periplasmic binding protein-like I 27 3.4
gi|1673470 [12..233] Protein kinases (PK), catalytic core 26 3.6
gi|232142 [190..392] P-loop containing nucleotide triphospha... 26 4.2
gi|2370487 [513..702] Gln-tRNA synthetase (GlnRS), C-termina... 26 5.3
gi|1477763 [233..705] Lipoxigenase, C-terminal domain 25 8.2
gi|1652862 [45..566] Periplasmic binding protein-like II 25 8.5
>gi|1881738 [246..599] Leucine-rich repeats
Length = 354
Score = 74.4 bits (180), Expect = 1e-14
Identities = 28/193 (14%), Positives = 28/193 (14%), Gaps = 24/193 (12%)
Query: 57 RRVVCSGGDLPEPPEPGL--LPNGTVTLLLSNNKITGLRN-----GSFLGLSLLEKLDLR 109
Sbjct: 16 SRVEGTASAFEELGQAIAKNRNSALTSIDWSNNLIKDAGVAALAAAVASMGHGLTSISLK 75
Query: 110 NNIISTVQPGAFLG--------LGELKRLDLSNNRIGCLTSETFQG----LPRLLRLNIS 157
Sbjct: 76 GGDATKKGTVALCTAFKKNVEMSRTLTVLNLAGNRLDSDGTSALAAFVSGPNALQTLNIS 135
Query: 158 GNIFSSLQ--PGVFDELPALKVVDLGTEFLT---CDCHLRWLLPWAQNRSLQLSEHTLCA 212
Sbjct: 136 GTAANLEMLLPAVMRGCTELEKFNISHNKVTAKTGPELKKFLQSCGRLSELHMRDTAVPV 195
Query: 213 YPSALHAQALGSL 225
Sbjct: 196 QVVRDVIKAIIGN 208
Score = 60.8 bits (145), Expect = 2e-10
Identities = 13/91 (14%), Positives = 13/91 (14%), Gaps = 7/91 (7%)
Query: 81 TLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCL 140
Sbjct: 271 ELHLGDNWTRNKTKARSQAVDNLIELISSECPLHKLDL-------SCKVADNQIKTDILP 323
Query: 141 TSETFQGLPRLLRLNISGNIFSSLQPGVFDE 171
Sbjct: 324 FIYSLATNDTLKELDISGNAMGDKVGIALGK 354
Score = 26.5 bits (57), Expect = 3.4
Identities = 10/95 (10%), Positives = 10/95 (10%), Gaps = 5/95 (5%)
Query: 127 LKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSL----QPGVFDELPALKVVDLGT 182
Sbjct: 217 DLAANKLGVLGANMLAGLAAEITTIKSLDLTDNDFGDEGMSIIADGLCHNSSLRELHLGD 276
Query: 183 EFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSAL 217
Sbjct: 277 NWTRNKTK-ARSQAVDNLIELISSECPLHKLDLSC 310
>gi|132575 [1..456] Leucine-rich repeats
Length = 456
Score = 71.0 bits (171), Expect = 1e-13
Identities = 26/165 (15%), Positives = 26/165 (15%), Gaps = 20/165 (12%)
Query: 80 VTLLLSNNKITGLR-NGSFLGLSLLEKLDLRNNIISTVQPG----AFLGLGELKRLDLSN 134
Sbjct: 1 MSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPALTELSLRT 60
Query: 135 NRIGCLTSETFQGL-----PRLLRLNISGN----IFSSLQPGVFDELPALKVVDLGTEFL 185
Sbjct: 61 NELGDAGVGLVLQGLQNPTCKIQKLSLQNCSLTEAGCGVLPDVLRSLSTLRELHLNDNPL 120
Query: 186 TCDCHLRWLLPWAQN-----RSLQLSEHTLCAYPSALHAQALGSL 225
Sbjct: 121 GDE-GLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLASVLRVK 164
Score = 62.4 bits (149), Expect = 5e-11
Identities = 18/108 (16%), Positives = 18/108 (16%), Gaps = 14/108 (12%)
Query: 84 LSNNKITGLRNGSFL-----GLSLLEKLDLRNNIISTVQ----PGAFLGLGELKRLDLSN 134
Sbjct: 343 MSSNPLGDSGVVELCKALGYPDTVLRVLWLGDCDVTDSGCSSLATVLLANRSLRELDLSN 402
Query: 135 NRI-----GCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKV 177
Sbjct: 403 NCMGDNGVLQLLESLKQPSCILQQLVLYDIYWTDEVEDQLRALEEERP 450
Score = 58.5 bits (139), Expect = 6e-10
Identities = 41/251 (16%), Positives = 41/251 (16%), Gaps = 38/251 (15%)
Query: 81 TLLLSNNKITGLRNGSFL----GLSLLEKLDLRNNIIS-----TVQPGAFLGLGELKRLD 131
Sbjct: 198 SLKLENCGITSANCKDLCDVVASKASLQELDLGSNKLGNTGIAALCSGLLLPSCRLRTLW 257
Query: 132 LSNNRIGCLTSET----FQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 187
Sbjct: 258 LWDCDVTAEGCKDLCRVLRAKQSLKELSLAGNELKDEGAQLLCESLLEPGCQLESLWVKT 317
Query: 188 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELH--THHLIP 245
Sbjct: 318 CSLTAA------------SCPHFCSVLTKNSSLFELQMSSNPLGDSGVVELCKALGYPDT 365
Query: 246 SLRQVVFQGDRL---PFQCSASYLGNDTRIRW---YHNRAPVEGDEQAGILLAESLIHDC 299
Sbjct: 366 VLRVLWLGDCDVTDSGCSSLATVLLANRSLRELDLSNNCMGDNGVLQ----LLESLKQPS 421
Query: 300 TFITSELTLSH 310
Sbjct: 422 CILQ-QLVLYD 431
>gi|1082610 [223..548] Leucine-rich repeats
Length = 326
Score = 66.1 bits (159), Expect = 4e-12
Identities = 27/198 (13%), Positives = 27/198 (13%), Gaps = 24/198 (12%)
Query: 82 LLLSNNKITGLRNGSFLGLSLLEKLDLRNNII------STVQPGAFLGLGELKRLDLSNN 135
Sbjct: 125 GFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLALKRLSFHDM 184
Query: 136 RIGCLTS--ETFQGLPRLLRLNISGNIFSSLQP--------GVFDELPALKVVDLG---- 181
Sbjct: 185 NLADCQSEVLFLLQNLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRL 244
Query: 182 -TEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHT 240
Sbjct: 245 GNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAF---GHLRLFQ 301
Query: 241 HHLIPSLRQVVFQGDRLP 258
Sbjct: 302 NWLDQDAVTAREAIRRLR 319
Score = 59.4 bits (142), Expect = 4e-10
Identities = 21/124 (16%), Positives = 21/124 (16%), Gaps = 16/124 (12%)
Query: 84 LSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGE-------------LKRL 130
Sbjct: 2 LSTEAALTLCH-LLSSWVSLESLTLSYNGLGSNIFRLLDSLRALSGQAGCRLRALHLSDL 60
Query: 131 DLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCH 190
Sbjct: 61 FSPLPILELT-RAIVRALPLLRVLSIRVDHPSQRDNPGVPGNAGPPSHIIGDEEIPE-NC 118
Query: 191 LRWL 194
Sbjct: 119 LEQL 122
>gi|1418519 [191..423] Leucine-rich repeats
Length = 233
Score = 65.2 bits (157), Expect = 6e-12
Identities = 22/118 (18%), Positives = 22/118 (18%), Gaps = 12/118 (10%)
Query: 75 LPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQ----PGAFLGLGELKRL 130
Sbjct: 99 LRNNSIGDSGVRHICDGLRHREAVEKSSLSAMVLWNNNVTGASMDSLAEALIENTKIETL 158
Query: 131 DLSNNRIGCLTSETFQG----LPRLLRLNISGNIFSSLQ----PGVFDELPALKVVDL 180
Sbjct: 159 NIGNNNLGVEGIARLKPALASNSHLHRLGLQNTGINCEGAIILAECIADNIALLRVDI 216
Score = 53.5 bits (127), Expect = 2e-08
Identities = 14/98 (14%), Positives = 14/98 (14%), Gaps = 14/98 (14%)
Query: 96 SFLGLSLLEKLDLRNNIISTVQP------GAFLGLGELKRLDLSNNRIGCLT----SETF 145
Sbjct: 1 SIRHAVSLQMLNLRYTNLNDRSIPALCKMARAQPSASLTCLHLENTQMSGKNLLVLICAL 60
Query: 146 QGLPRLLRLNISGNIFSSLQ----PGVFDELPALKVVD 179
Sbjct: 61 KNNTGLRELYLGDNGLQPTDGSHIYQLITSNSSLQLLD 98
>gi|2623618 [35..332] Leucine-rich repeats
Length = 298
Score = 64.6 bits (155), Expect = 1e-11
Identities = 24/177 (13%), Positives = 24/177 (13%), Gaps = 16/177 (9%)
Query: 65 DLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQ----PGA 120
Sbjct: 108 SLREMRFNNNGLGIGGKLMAEALITCHEKSTKAGKPLALKVFIAGRNRLENPGATVLAKA 167
Query: 121 FLGLGELKRLDLSNNRIGCLTS----ETFQGLPRLLRLNISGNIFSSLQ----PGVFDEL 172
Sbjct: 168 FKIIGTLEEIALPQNGINYEGITALAEAVEYSHNLKILNLNDNTFTARGAKPMAKAIKNL 227
Query: 173 PALKVVDL-GTEFLTCDCHLRWLLPWAQN---RSLQLSEHTLCAYPSALHAQALGSL 225
Sbjct: 228 SKLEVINFGDCLVRSEGADAIANSLREGVPSLKELNLAFGEIKKEAAVRVAESMDTK 284
Score = 50.6 bits (119), Expect = 2e-07
Identities = 13/80 (16%), Positives = 13/80 (16%), Gaps = 4/80 (5%)
Query: 118 PGAFLGLGELKRLDLSNNRIGCLTSETF----QGLPRLLRLNISGNIFSSLQPGVFDELP 173
Sbjct: 7 VAAVEACEGIQSLKLNGNTIGVEAAQALAKALESKPQFQRARWSDMFTGRLRSEIPPALM 66
Query: 174 ALKVVDLGTEFLTCDCHLRW 193
Sbjct: 67 SLGAGIMTAGAHLVEIDLSD 86
Score = 33.5 bits (75), Expect = 0.021
Identities = 4/52 (7%), Positives = 4/52 (7%), Gaps = 5/52 (9%)
Query: 69 PPEPGLLPNGTVTLLLSNNKITGLRNGSFL----GLSLLEKLDLRNNIISTV 116
Sbjct: 7 VAAVEACEGIQS-LKLNGNTIGVEAAQALAKALESKPQFQRARWSDMFTGRL 57
>gi|1652821 [74..598] Periplasmic binding protein-like II
Length = 525
Score = 31.2 bits (70), Expect = 0.10
Identities = 14/78 (17%), Positives = 14/78 (17%), Gaps = 10/78 (12%)
Query: 1081 SPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVC 1140
Sbjct: 130 PILPAHILRETVEKTDENGNPLFLSTW-----GTNTPPDQIVVNGPYKLTRYVTSQRVIF 184
Query: 1141 EA-----GAAAGGEGEPE 1153
Sbjct: 185 SKNPYYWEKGPNGESLPY 202
>gi|485157 [209..476] Protein kinases (PK), catalytic core
Length = 268
Score = 28.2 bits (61), Expect = 0.79
Identities = 12/147 (8%), Positives = 12/147 (8%), Gaps = 18/147 (12%)
Query: 452 DMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGA 511
Sbjct: 97 SENERLDILAQICRGMSFLHTRTPSI-VHGDLAARNVLLKKHPVY--IKKYICKITDLGL 153
Query: 512 LERIGGAALSPHAQHISVNARNVALEAYLIKPHSY----VGLTCTAFQRREGGVPGTRPG 567
Sbjct: 154 AKTCLDELYTSYDDPTKIPFKWLPPEVLGSRTLSLKTDIWAFGIVCFEVCDKV------- 206
Query: 568 SPGQNPPPEPEPPADQQLRFRCTTGRP 594
Sbjct: 207 ----GEPYGACVPTSNLCQYLTDGYVH 229
>gi|2499672 [624..853] Protein kinases (PK), catalytic core
Length = 230
Score = 27.3 bits (59), Expect = 1.8
Identities = 7/109 (6%), Positives = 7/109 (6%), Gaps = 13/109 (11%)
Query: 770 TALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMT----SAVFAGGITLTNYQ 825
Sbjct: 56 CLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNSYVLDAKISDPGYPRPYRESD 115
Query: 826 MVCQA-----VGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDP 869
Sbjct: 116 SPWIPVKYYRNLQAAKTDQFAQLWAFA----TTIYEIFSRCKEDLSTLR 160
>gi|1536958 [63..316] Periplasmic binding protein-like I
Length = 254
Score = 26.5 bits (58), Expect = 3.4
Identities = 5/79 (6%), Positives = 5/79 (6%), Gaps = 6/79 (7%)
Query: 411 LYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYV 470
Sbjct: 175 IDPDEKTLVFIPNCWALPLVFTVI-KELNYNLPQVGLIGFDN----TEWTCFSSPSVSTL 229
Query: 471 DQ-IKELVEVMVDMASNLM 488
Sbjct: 230 VQPSFEEGQQATKILIDQI 248
>gi|1673470 [12..233] Protein kinases (PK), catalytic core
Length = 222
Score = 26.3 bits (56), Expect = 3.6
Identities = 10/101 (9%), Positives = 10/101 (9%), Gaps = 4/101 (3%)
Query: 226 QEAQLCCE-GALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGD 284
Sbjct: 47 TELSVFRKLDSLGNSKRNGFPQFCENFQVDGYYAIVLSDEGDNLNDIRKRNKNLVFNRKN 106
Query: 285 ---EQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECT 322
Sbjct: 107 VATVGCAVSRSLSTLHSIGFFHADLHEQNLMVPYPCRKINI 147
>gi|232142 [190..392] P-loop containing nucleotide triphosphate hydrolases
Length = 203
Score = 26.0 bits (56), Expect = 4.2
Identities = 6/46 (13%), Positives = 6/46 (13%), Gaps = 2/46 (4%)
Query: 174 ALKVVDL--GTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSAL 217
Sbjct: 40 IIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVIL 85
>gi|2370487 [513..702] Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain
Length = 190
Score = 25.6 bits (55), Expect = 5.3
Identities = 19/74 (25%), Positives = 19/74 (25%), Gaps = 11/74 (14%)
Query: 437 AHQLRVYTAEAASFSDMMDV-------VYVAQMIQKFLGYVDQIKELVEVMVDMASNLML 489
Sbjct: 46 ANEILIEQADAQSFKQDEEVTLMDWGNAYVREINRDASGKVTSLK--LELHLD--GDFKK 101
Query: 490 VDEHLLWLAQREDK 503
Sbjct: 102 TEKKVTWLADTEDK 115
>gi|1477763 [233..705] Lipoxigenase, C-terminal domain
Length = 473
Score = 25.2 bits (55), Expect = 8.2
Identities = 25/147 (17%), Positives = 25/147 (17%), Gaps = 27/147 (18%)
Query: 614 LPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLF----------HSHSNTSRPGAAGPGK 663
Sbjct: 53 FINKTY-DWDAAMQRASGEDSTFSEMI-DAGRVYIVEFSYLYDLSNVEDLTERNTTDRRE 110
Query: 664 RRGVATP-VIFAGTSGCGVGNLTEPVAV--SLRHWAEGAEPVAAWWSQEGPGEAGGWTSE 720
Sbjct: 111 MRGSRAPICTFVSANVGGVRELK-PVAIQTDQSSDAPVFSPVDGSK----------WLMA 159
Query: 721 GCQLRSSQPNVSALHCQHLGNVAVLME 747
Sbjct: 160 KQEFQRADITYAEII-EHLLKTHLLME 185
>gi|1652862 [45..566] Periplasmic binding protein-like II
Length = 522
Score = 24.9 bits (54), Expect = 8.5
Identities = 8/58 (13%), Positives = 8/58 (13%), Gaps = 9/58 (15%)
Query: 155 NISGNIFSSL---------QPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSL 203
Sbjct: 26 EASRIALEPLASFDQEGNLVPFLAAEIPSVENGGVAADGLSVTWKLKPDVLWSDGQPF 83
Underlying Matrix: BLOSUM62
Number of sequences tested against query: 1187
Number of sequences better than 10.0: 14
Number of calls to ALIGN: 22
Length of query: 1400
Total length of test sequences: 256703
Effective length of test sequences: 207231.0
Effective search space size: 281427601.4
Initial X dropoff for ALIGN: 25.0 bits
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
calculation of internal repeats with prospero
***** PROSPERO v1.3 Tue Jan 22 00:20:53 2002 *****
Copyright 2000, Richard Mott, Wellcome Trust Centre for Human Genetics, University of Oxford
For help see http://www.well.ox.ac.uk/ariadne For usage use -help
using gap penalty 11+1k
using matrix BLOSUM62
printing all alignments with eval < 0.100000
using sequence1 gi|17511205|ref|NP_116166.6|
using self-comparison
> 1 gi|17511205|ref|NP_116166.6| len 1331 from 84 to 151 vs gi|17511205|ref|NP_116166.6| len 1331 from 108 to 175 score 118 eval 6.420982e-08 identity 42.65% K 2.085770e-02 L 2.294784e-01 H 1.299330e+00 alpha 1.011140e-01
84 LSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSE 143 gi|17511205|ref|NP_116166.6|
| || |: :: |:|||| |::||| || | : | || | ||::| | |
108 LRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPG 167 gi|17511205|ref|NP_116166.6|
144 TFQGLPRL 151 gi|17511205|ref|NP_116166.6|
| || |
168 VFDELPAL 175 gi|17511205|ref|NP_116166.6|
> 2 gi|17511205|ref|NP_116166.6| len 1331 from 84 to 139 vs gi|17511205|ref|NP_116166.6| len 1331 from 132 to 187 score 102 eval 2.524527e-06 identity 42.86% K 2.085770e-02 L 2.294784e-01 H 1.299330e+00 alpha 1.011140e-01
84 LSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGC 139 gi|17511205|ref|NP_116166.6|
||||:| | : :| || | :|:: || |::||| | | || :|| : |
132 LSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 187 gi|17511205|ref|NP_116166.6|
> 3 gi|17511205|ref|NP_116166.6| len 1331 from 1066 to 1219 vs gi|17511205|ref|NP_116166.6| len 1331 from 1070 to 1231 score 57 eval 7.418301e-02 identity 31.03% K 2.085770e-02 L 2.294784e-01 H 1.299330e+00 alpha 1.011140e-01
1066 RRDVRASWRACCPPASPAAPHAPPRALPAAAE---DGSPVFGEGPPSLKSSPSGSSGHPL 1122 gi|17511205|ref|NP_116166.6|
| || | | | | | | | : :| | | | |
1070 RASWRACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALG--PC 1127 gi|17511205|ref|NP_116166.6|
1123 ALGPCKLTNLQLAQSQVCEAGAAAGGEGEP----------EPAGT-RGNLAHRHPNNVHH 1171 gi|17511205|ref|NP_116166.6|
| :| |: :: | | || || | | ||: |
1128 KLTNLQLAQSQVCEA---GAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHR 1184 gi|17511205|ref|NP_116166.6|
1172 -GRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSES--GSLHNSP 1219 gi|17511205|ref|NP_116166.6|
| |:| | | | | | : :|:| ::| || |||
1185 AGEACGKNRLKALRGGAAGALELLSS----ESGSLHNSPTDSYLGSSRNSP 1231 gi|17511205|ref|NP_116166.6|
~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~
TIGRFAM
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /data/patterns/tigrfam/tigrfam.hmm
Sequence file: tem9.fa
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
TIGR00099 TIGR00099: conserved hypothetical protein 1.5 14 1
TIGR00097 HMP-P_kinase: phosphomethylpyrimidine kinas -0.1 76 1
TIGR00797 matE: MATE efflux family protein -217.3 12 1
TIGR00813 sss: SSS sodium solute transporter superfam -230.6 41 1
TIGR00933 2a38: K+ Transporter (Trk) Family protein -277.8 99 1
TIGR00801 ncs2: uracil-xanthine permease -319.6 62 1
TIGR00819 ydaH: AbgT putative transporter family -354.3 93 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
TIGR00099 1/1 459 467 .. 302 310 .] 1.5 14
TIGR00097 1/1 671 682 .. 258 269 .] -0.1 76
TIGR00797 1/1 457 940 .. 1 412 [] -217.3 12
TIGR00819 1/1 495 954 .. 1 527 [] -354.3 93
TIGR00933 1/1 748 1029 .. 1 409 [] -277.8 99
TIGR00801 1/1 725 1057 .. 1 480 [] -319.6 62
TIGR00813 1/1 691 1076 .. 1 448 [] -230.6 41
Alignments of top-scoring domains:
TIGR00099: domain 1 of 1, from 459 to 467: score 1.5, E = 14
*->vAqflkefL<-*
vAq++++fL
gi|1751120 459 VAQMIQKFL 467
TIGR00097: domain 1 of 1, from 671 to 682: score -0.1, E = 76
*->iaqalnigvGhG<-*
++ a ++g+G+G
gi|1751120 671 VIFAGTSGCGVG 682
TIGR00797: domain 1 of 1, from 457 to 940: score -217.3, E = 12
*->PailanilqpllglvDtafvGhlg.pvdLaAvglgissvfmllisil
++++q++ f+G++++ +L+ v + +s +ml+ l
gi|1751120 457 ----VYVAQMIQK-----FLGYVDqIKELVEVMVDMASNLMLVDEHL 494
lGlgtattalvaqavGagnrq.............................
l l+ + +++ vGa r ++ +++ ++ + + ++ + +++
gi|1751120 495 LWLAQREDKACSRIVGALERIggaalsphaqhisvnarnvaleaylikph 544
..................................................
+ + + + ++++++ +++++++++++++++++++ +++ + + +++++
gi|1751120 545 syvgltctafqrreggvpgtrpgspgqnpppepeppadqqlrfrcttgrp 594
..................................................
+ + ++ + +++ + + +++ ++ + ++ +++ + + +++
gi|1751120 595 nvslssfhiknsvalasiqlppslfsslpaalappvppdctlqllvfrng 644
.................rlarqaqqslllalllGlpvllvglffidplls
+ ++++++++++ ++ +r + +++++a++ G +v ++ + + l +
gi|1751120 645 rlfhshsntsrpgaagpGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRH 694
lmgadgevaelAqeYLrililg..iPayllsfvlr.gfLrGqgdTktpmy
+ ++ ++va +++++ P+ + + ++ Lr+ + + ++
gi|1751120 695 WAEGAEPVAA---------WWSqeGPGEAGGWTSEgCQLRSSQPNVSALH 735
itlignllNivLdyiLIfGkFGfP.elGivGAAlATvisywlmfllllyy
+ +gn++ +++ + fP+e G++GA+l + ++y +++llll++
gi|1751120 736 CQHLGNVA-----VLMEL--SAFPrEVGGAGAGL-HPVVYPCTALLLLCL 777
ikksaqakkiglkwegllkpdwevlkrllklGlPialrvileslsfalva
+ + ++ + ++++++ + G+ +l++++ ++ +v
gi|1751120 778 FA-------TIIT----YILNHSSIRVS-RKGWHMLLNLCFHIAMTSAVF 815
llvarlGg.sialAahqvalnvesllfmpafGlgiAvsilVGqaLGagdp
+ + l + + a +++l +sl++++ +G+ + ++
gi|1751120 816 AGGITLTNyQMVCQAVGITLHYSSLSTLLWMGV-------------KARV 852
krAkevarvalklslllglvlaiililfrevglPiarlFTndpeVlelaa
+ ++++r + +++ dp+ + +
gi|1751120 853 LHKELTWR------------------APPPQ--------EGDPALPTPSP 876
syLifvalfqfsdgiqfvlsGvlrGaGd..tkviliitfisywvigLPvg
+ +++ + ++++i+ ++ +v++ ++++ ++ + s+ +++Pv+
gi|1751120 877 MLRFYLIAGGIPLIICGITAAVNIHNYRdhSPYCWLVWRPSLGAFYIPVA 926
yllgrTDlfytglGlkGlW<-*
++l ++t++ ++ +
gi|1751120 927 LIL-----LITWIYFLCAG 940
TIGR00819: domain 1 of 1, from 495 to 954: score -354.3, E = 93
*->mPMSqssiPdarrSGkllrtVErlGNkl..PHP.........vlLFI
+ + q + + ++ + Er+G +PH ++ + + ++v L
gi|1751120 495 LWLAQR---EDKACSRIVGALERIGGAAlsPHAqhisvnarnVALEA 538
ilI....vlLlvasAv........laaFGlSvkdPRPvGAKGRaDdtlvv
+lI++++ + l +A ++++++ ++ G +P P aD l
gi|1751120 539 YLIkphsYVGLTCTAFqrreggvpGTRPGSPGQNP-PPEPEPPADQQL-R 586
VksLLdvdGLkiltnvvKNFsGFAPLGavLvllLGvGlAEkvGLlsALMv
+ +KN ++ + + L s L
gi|1751120 587 FRCTTGRPNVSLSSFHIKN------------SVALASIQLPPSLFSSLPA 624
kllskvnaklasyMVlFi.ailSniaSdlalVvliPlsAlIFlalG.RHP
l+ v+ + + +F ++ l + S+ P A G+R
gi|1751120 625 ALAPPVPPDCTLQLLVFRnGRLFHSHSNTS----RPGAA----GPGkRRG 666
lAGLlAAiAGVsgGysANLllvTiDvLLaGIsteAAaiinPdyvVsvidN
+A + +AG sg NL + + A + +++
gi|1751120 667 VATPV-IFAGTSGCGVGNL----TEPV-------AVSLRHWAEGAEPVAA 704
WyFMAaSvvVlalvGylvTdKIvEPrLGqyQsDLssdEKDiRHlnelTel
W+ S G+ + q s s+ H + l
gi|1751120 705 WW----SQEGPGEAGGWTSEGC------QLRS--SQPNVSALHCQHL--- 739
erkGLiiAGVVfllliAllAlsvvPadGILRdPitglVag.SPFlKsIVv
G V +l+ ls P + + g ag P +
gi|1751120 740 --------GNVAVLME----LSAFPRE------VGGAGAGlHPVVYPCTA 771
lIiLlFalvslvYGiiTRslRreadlvnlMiEsMkelalylVi...vFfl
l +L + + Y s+R + +++ l + +++ vF
gi|1751120 772 LLLLCLFATIITYILNHSSIRVSRKGWHMLL----NLCFHIAMtsaVF-- 815
AQFVAfFNWsNiGkyIAVklaviLkevGLaGivlFvGliLlsaFlnlfIa
A + + N + + AV+ + L + L+ l G l
gi|1751120 816 AGGITLTNYQMVCQ--AVGIT--LHYSSLS-TLLWMGVKARVLHKELTWR 860
SaSAiWavlA.PIFVPMlMLlGyaPeviQilyRIaDSv.vlilaPvssyv
+ A P PMl a + i+ I v++ s+y
gi|1751120 861 APPPQEGDPAlPTPSPMLRFYLIAGGIPLIICGITAAVnIHNYRDHSPYC 910
gLilaflqkYKkDAklGTliSlvLPYsliFLvvWllllliWvlVLGLPvG
L+ +++ lG ++ P li L+ W+ l++ G
gi|1751120 911 WLV------WRP--SLGAFY---IPVALILLITWIYFLCAGLRL----RG 945
PGAPtlYPals<-*
P P+
gi|1751120 946 PL--AQNPKAG 954
TIGR00933: domain 1 of 1, from 748 to 1029: score -277.8, E = 99
*->LlaLPfvisssplsfiDALFtAtSAvTvTGLTVldtleslpkaglfl
L+a+P ++ v + G+ + + +p l+l
gi|1751120 748 LSAFP----RE--------------VGGAGAGLHP-VV-YPCTALLL 774
rslLqqIGGLGfmvlavailillGkKislgarlylaEalgplsmdkllpl
+ l +a+ i ++l+ + r ++ g + m
gi|1751120 775 LCL-----------FATIITYILNH---SSIRVSRK---G-WHM------ 800
ikkiakfifvIyllgaillavrfvleGGwemsLFdAifHsiSAfnNGGFS
ll ++f++++ +s +A + +++++ +
gi|1751120 801 -----------------LLNLCFHIAM---TSAVFAGGITLTNYQ---MV 827
thsdssigYfndplvnlViafLiIlGGlgFtVhydvylllrkkvkkkffk
++ +++++ ++L +G ++h + l++r +
gi|1751120 828 CQAVGITLHYSSL------STLLWMGVKARVLHKE--LTWR----A---P 862
g....kvlsldtklvlfvtllllaigfililllergNpktlyslslgall
++++++ + + ++l+++l++ i+ i+ ++ + +++
gi|1751120 863 PpqegDPALPTPSPMLRFYLIAGGIPLIICGITAA------V-NIH---- 901
lsaFfqsstlrTAGFstlD....nlaalseatlvlllllMfIGGasGSTa
++ D+++ + ++++ + ++ ++I
gi|1751120 902 ---------------NYRDhspyCWLVWRPSLGAFYIPVALI-------- 928
GGIKvttfaillksvyseirrgkhpriVkiifsrkiggktiekailisvv
++i+++++ r+++p + + + +++++a ++ +
gi|1751120 929 -------LLITWIYFLCAGLRLRGPLA---QNPKAGNSRASLEAGEELRG 968
sfflvfalifllsllelissgydfltllFEvvSAfatVGLSvGnvgtasl
s+ l +l d +ll++ ++ ++t G+ g
gi|1751120 969 STRLRGSGPLL----------SDSGSLLATGSARVGTPGPPED--GDSLY 1006
taeLpdlgKli...livlMfiGR<-*
++ ++++++ l +M+
gi|1751120 1007 SPGVQLGALVTthfLYLAMWACG 1029
TIGR00801: domain 1 of 1, from 725 to 1057: score -319.6, E = 62
*->RppflrrqtlvlgLQH...............................
R + + + l +QH ++ + + +++ ++ + + ++ +
gi|1751120 725 RSSQP--NVSALHCQHlgnvavlmelsafprevggagaglhpvvypc 769
...LlAMFgatVlVPlLvGlapGLqgLsaeqlqYLvsiaLltsGigTLLQ
+ Ll + at+ +L ++++ +s +L++
gi|1751120 770 talLLLCLFATIITYILNHSSI---RVSRKGWHMLLN------------- 803
lfrtggqgtrYYVGiGlPsyLGsSFafvaVaiglpmiaigsgyCqlDgqG
+++++ + +S++f + ++ + +++ +
gi|1751120 804 -LCFHIAM--------------TSAVFAGGITLTNYQMVCQA-------- 830
nrlGipaimggliatGlvytllallikklgtrwlrrlfPPvVtGpVVmlI
Gi +++l t l ++ a+++ k +t
gi|1751120 831 --VGITLHYSSL-STLLWMGVKARVLHKELT------------------- 858
GLsLipvAvkmaaGGeaakssnnGaLCPSAdAPrPltygslenllvafvV
+ + ++ ++ l+++
gi|1751120 859 -----------WRAPPPQEGDP------------ALPTP----------- 874
LaliillnrFakGflksisILiGivvGYllAlamGlVdfsp.vkeApwfs
+++l+ I Gi +++ + +V+ + ++ p
gi|1751120 875 -----------SPMLRFYLIAGGIPL--IICGITAAVNIHNyRDHSPYCW 911
lPkpftfGvdYapsFelpailtmlpVaivtlvEsiGdltA.........t
l++ + G a+ + ++il+++ +++ ++ +A++++ ++++
gi|1751120 912 LVWRPSLG---AFYIPVALILLITWIYFLCAGLRLRGPLAqnpkagnsrA 958
advtgrdlsgetydprLhrG..vlaDGlatll..aglvGgfPnTtFaQNi
+ g +l+g + rL +++++l+D + l ++++ vG+++
gi|1751120 959 SLEAGEELRG---STRLRGSgpLLSDSGSLLAtgSARVGTPG-------- 997
GVialTrVaSryVivgaAviLialGfvPKiaAlitsIPspVLGGasivmF
+ + ++v ++Al+t+ +++
gi|1751120 998 ------PPEDGDSLYSPGV---------QLGALVTT----------HFLY 1022
GmIaasGiRiLirnkldfrrnlliiaaSvgLGlGvtgapdifgnfpPesd
+ ++ l v+++ ++ p
gi|1751120 1023 -------LAMWACGALA-----------------VSQR--WL---P---- 1039
NrdLEGleAiellllsGialagivAilLNlI<-*
+++ + +l g++A L l+
gi|1751120 1040 ----------RVVCS---CLYGVAASALGLF 1057
TIGR00813: domain 1 of 1, from 691 to 1076: score -230.6, E = 41
*->YflAGRslgglvvaaSLfAsniSasqflGlpGaiYayGLgevll.ai
sl ++ +a +A++ S + +pG++ G ++++++
gi|1751120 691 ------SLRHWAEGAEPVAAWWSQE----GPGEA---G---GWTsEG 721
gfyelgaLvllii....lgwlfvpvyikngalTmpeyLekRFgkghRilr
+++ + ++ ++ ++lg ++v+ ++ + p+ + + ++
gi|1751120 722 CQLRSSQPNVSALhcqhLGNVAVLMELSA----FPREVGGAGAG-LHPVV 766
glsvLslilyiflymsvdlfsGAlllelvlGldlylsllllgaitilYTv
+ ++ l+l++f ++ ++ + + + G+ +l +l + ++++ ++
gi|1751120 767 YPCTALLLLCLFATIITYILNHSSIRVSRKGWH-MLLNLCFHIAMTSAVF 815
fGGlkAvvwTDtiQCavimilGtlilpvfafsevGGslgsvvekasqaap
GG+ + + + Q av ++ l + +s +g +++ + +
gi|1751120 816 AGGITLTNYQMVCQ-AV-----GITLHYSSLSTLLW-MGVKARVLHKELT 858
slvvpsggNltiksCyt.PvddlldffrdpltsdlpwgagvfGlphvalw
+ P+ + d + +++ +l+ + G+p++
gi|1751120 859 ---------------WRaPPPQEGDPALPTPSPMLRFYLIAGGIPLI--- 890
YwctnQvivqRclAaksakhak.kgcliagvl...kllpmflavlpGlia
+ ++Aa +++ ++++ + +v+++++ +++++ l+ li
gi|1751120 891 --------ICGITAAVNIHNYRdHSPYCWLVWrpsLGAFYIPVALILLIT 932
ralytdpiacidPalagavcgtevqasdqayPlLvvkllpdlpglaGlfl
+++ +c+ l g+ +q++ ++ + + l g l
gi|1751120 933 WIYF----LCAGLRLR----GPLAQNPKAGNSRASLEAGEELRGSTRLRG 974
AvllAAvmStlssiLnsaStvft......mD...lYkkiirpaaetekli
+++l +S s+ L+++ ++ ++++++++D+++lY++ a
gi|1751120 975 SGPL---LSD-SGSLLATGSARVgtpgppEDgdsLYSPGVQLGAL----- 1015
vgrgrvavlvaiviailpavaaaqggqvlqlvqeafgilgapflpvfvLG
v+ ++ + ++ a++ v + +v+ ++ +++a++l++fv++
gi|1751120 1016 VTTHFLYLAMWACGALA--VSQRWLPRVVCSCLY---GVAASALGLFVFT 1060
lFwkRmNakGAlaGPimiiG<-*
+ R + A + +
gi|1751120 1061 HHCARRRDVRASWR----AC 1076
//
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /data/patterns/tigrfam/tigrfam.hmm-f
Sequence file: tem9.fa
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
TIGR00099 TIGR00099: conserved hypothetical protein 1.5 13 1
TIGR00097 HMP-P_kinase: phosphomethylpyrimidine kinas -0.1 76 1
TIGR00936 ahcY: adenosylhomocysteinase -0.7 32 1
TIGR00297 TIGR00297: conserved hypothetical protein T -0.7 92 1
TIGR00886 2A0108: nitrate transporter -1.3 70 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
TIGR00099 1/1 459 467 .. 302 310 .] 1.5 13
TIGR00097 1/1 671 682 .. 258 269 .] -0.1 76
TIGR00297 1/1 766 785 .. 1 20 [. -0.7 92
TIGR00886 1/1 927 937 .. 1 11 [. -1.3 70
TIGR00936 1/1 1009 1030 .. 401 422 .] -0.7 32
Alignments of top-scoring domains:
TIGR00099: domain 1 of 1, from 459 to 467: score 1.5, E = 13
*->vAqflkefL<-*
vAq++++fL
gi|1751120 459 VAQMIQKFL 467
TIGR00097: domain 1 of 1, from 671 to 682: score -0.1, E = 76
*->iaqalnigvGhG<-*
++ a ++g+G+G
gi|1751120 671 VIFAGTSGCGVG 682
TIGR00297: domain 1 of 1, from 766 to 785: score -0.7, E = 92
*->iflwlsavllcvfllllaly<-*
+++ +llc f+ +++++
gi|1751120 766 VYPCTALLLLCLFATIITYI 785
TIGR00886: domain 1 of 1, from 927 to 937: score -1.3, E = 70
*->RnLffSwfgFf<-*
+L ++w++F+
gi|1751120 927 LILLITWIYFL 937
TIGR00936: domain 1 of 1, from 1009 to 1030: score -0.7, E = 32
*->GieideLTeeQkkYLesweeGt<-*
G+++ L +YL +w++G
gi|1751120 1009 GVQLGALVTTHFLYLAMWACGA 1030
//
SMART
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /data/patterns/iprscan/data/smart.HMMs
Sequence file: tem9.fa
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
LRR_TYP Leucine-rich repeats, typical (most populate 57.4 3.2e-13 4
LRRCT Leucine rich repeat C-terminal domain 35.2 1.5e-06 1
IG Immunoglobulin 26.4 0.00066 1
GPS G-protein-coupled receptor proteolytic site 21.0 0.0035 1
HormR Domain present in hormone receptors 11.0 0.014 1
LRR_SD22 Leucine-rich repeat, SDS22-like subfamily 10.6 6.8 2
LRR_PS Leucine-rich repeat, plant-specific subfamil 7.2 23 3
LRR_RI Leucine rich repeat, ribonuclease inhibitor 6.0 6.3 1
LRR_CC Leucine-rich repeat - CC (cysteine-containin 1.8 72 1
LRR_BAC Leucine-rich repeats, bacterial type 0.6 88 2
IGc2 Immunoglobulin C-2 Type -1.6 1.4 1
IGv Immunoglobulin V-Type -20.2 50 1
ZU5 Domain present in ZO-1 and Unc5-like netrin -52.5 98 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
LRR_TYP 1/4 75 99 .. 1 24 [] 5.9 13
LRR_SD22 1/2 100 121 .. 1 22 [] 2.3 72
LRR_PS 1/3 100 122 .. 1 24 [] 1.5 1.3e+02
LRR_TYP 2/4 100 123 .. 1 24 [] 21.2 0.024
LRR_BAC 1/2 124 143 .. 1 20 [] 1.1 75
LRR_PS 2/3 124 146 .. 1 24 [] 6.0 34
LRR_TYP 3/4 124 147 .. 1 24 [] 27.8 0.00025
LRR_RI 1/1 124 150 .. 1 28 [] 6.0 6.3
LRR_SD22 2/2 124 150 .. 1 22 [] 8.4 13
LRR_CC 1/1 124 151 .. 1 26 [] 1.8 72
LRR_PS 3/3 148 170 .. 1 24 [] 5.8 36
LRR_TYP 4/4 148 171 .. 1 24 [] 14.0 1.4
LRR_BAC 2/2 148 175 .. 1 20 [] 0.5 90
LRRCT 1/1 183 233 .. 1 55 [] 35.2 1.5e-06
IGv 1/1 256 323 .. 1 76 [] -20.2 50
IGc2 1/1 252 328 .. 1 56 [] -1.6 1.4
IG 1/1 246 339 .. 1 58 [] 26.4 0.00066
HormR 1/1 342 419 .. 1 89 [] 11.0 0.014
ZU5 1/1 606 717 .. 1 115 [] -52.5 98
GPS 1/1 699 751 .. 1 51 [] 21.0 0.0035
Alignments of top-scoring domains:
LRR_TYP: domain 1 of 4, from 75 to 99: score 5.9, E = 13
*->LpnL.reLdLsnNqLtsLPpgaFqg<-*
Lpn + +L LsnN++t L +g F g
gi|1751120 75 LPNGtVTLLLSNNKITGLRNGSFLG 99
LRR_SD22: domain 1 of 2, from 100 to 121: score 2.3, E = 72
*->LtnLeeLdLsqNkIkkiENLde<-*
L+ Le LdL++N I+ ++
gi|1751120 100 LSLLEKLDLRNNIISTVQPGAF 121
LRR_PS: domain 1 of 3, from 100 to 122: score 1.5, E = 1.3e+02
*->LtsLqvLdLsnNnLsGeIPsslgn<-*
L+ L+ LdL nN +s ++ + +
gi|1751120 100 LSLLEKLDLRNNIIS-TVQPGAFL 122
LRR_TYP: domain 2 of 4, from 100 to 123: score 21.2, E = 0.024
*->LpnLreLdLsnNqLtsLPpgaFqg<-*
L+ L++LdL nN ++++ pgaF g
gi|1751120 100 LSLLEKLDLRNNIISTVQPGAFLG 123
LRR_BAC: domain 1 of 2, from 124 to 143: score 1.1, E = 75
*->PpsLkeLnvsnNrLteLPeL<-*
+Lk+L+ snNr+ +L
gi|1751120 124 LGELKRLDLSNNRIGCLTSE 143
LRR_PS: domain 2 of 3, from 124 to 146: score 6.0, E = 34
*->LtsLqvLdLsnNnLsGeIPsslgn<-*
L L++LdLsnN++ + s+ ++
gi|1751120 124 LGELKRLDLSNNRIG-CLTSETFQ 146
LRR_TYP: domain 3 of 4, from 124 to 147: score 27.8, E = 0.00025
*->LpnLreLdLsnNqLtsLPpgaFqg<-*
L++L++LdLsnN++ L +++Fqg
gi|1751120 124 LGELKRLDLSNNRIGCLTSETFQG 147
LRR_RI: domain 1 of 1, from 124 to 150: score 6.0, E = 6.3
*->npsLreLdLsnNklgdeGaraLaeaLks<-*
+ L++LdLsnN +g+ + ++L
gi|1751120 124 LGELKRLDLSNNRIGCLTSETF-QGLPR 150
LRR_SD22: domain 2 of 2, from 124 to 150: score 8.4, E = 13
*->LtnLeeLdLsqNkI.....kkiENLde<-*
L +L+ LdLs+N+I+ +++ +++L
gi|1751120 124 LGELKRLDLSNNRIgcltsETFQGLPR 150
LRR_CC: domain 1 of 1, from 124 to 151: score 1.8, E = 72
*->CpnLkeLdLsgCs..niTDeglqaLakg<-*
Lk+LdLs+ + +++T e++q L ++
gi|1751120 124 LGELKRLDLSNNRigCLTSETFQGLPRL 151
LRR_PS: domain 3 of 3, from 148 to 170: score 5.8, E = 36
*->LtsLqvLdLsnNnLsGeIPsslgn<-*
L++L +L++s+N +s ++ + ++
gi|1751120 148 LPRLLRLNISGNIFS-SLQPGVFD 170
LRR_TYP: domain 4 of 4, from 148 to 171: score 14.0, E = 1.4
*->LpnLreLdLsnNqLtsLPpgaFqg<-*
Lp L +L+ s+N ++sL pg+F+
gi|1751120 148 LPRLLRLNISGNIFSSLQPGVFDE 171
LRR_BAC: domain 2 of 2, from 148 to 175: score 0.5, E = 90
*->PpsLkeLnvsnNrLt........eLPeL<-*
p+L +Ln+s+N ++ +++ +eLP+L
gi|1751120 148 LPRLLRLNISGNIFSslqpgvfdELPAL 175
LRRCT: domain 1 of 1, from 183 to 233: score 35.2, E = 1.5e-06
*->NPfnCDCeLrwLlrwleaqnnealqdpvsslrCasPeslrGqpllll
+ CDC+LrwLl+w ++ + lq ++ +++Ca+P++l+ + l +
gi|1751120 183 EFLTCDCHLRWLLPWAQN---RSLQLSE-HTLCAYPSALHA-QALGS 224
lp.sefsCp<-*
l ++ C+
gi|1751120 225 LQeAQLCCE 233
IGv: domain 1 of 1, from 256 to 323: score -20.2, E = 50
*->svtLsCkaSgftf..yvsWvrqpPsstgkgkglewlgy.sykgRvti
+ +C+aS +++ + W++ + +g+ ++ +l+++ + + i
gi|1751120 256 RLPFQCSASYLGNdtRIRWYHNRAPVEGDEQAGILLAEsLIHDCTFI 302
skdtltraskndvsLtisnLrpeDtgtYyCar<-*
+ Lt+s + +g C +
gi|1751120 303 TSE-----------LTLSHIGVWASGEWECTV 323
IGc2: domain 1 of 1, from 252 to 328: score -1.6, E = 1.4
*->leGqsVtLtCpasgdpvpn.ItWlk.gkplp................
+G+ + ++C as + ++I+W+++ p++++++ + ++ ++
gi|1751120 252 FQGDRLPFQCSASYLGNDTrIRWYHnRAPVEgdeqagillaeslihd 298
...sgstLtiknvsleDsGlYtCvArNsvg<-*
+ s+Lt++++ + sG+ +C+++ + g
gi|1751120 299 ctfITSELTLSHIGVWASGEWECTVSMAQG 328
IG: domain 1 of 1, from 246 to 339: score 26.4, E = 0.00066
*->pp.vtvkeGesvtLtC.as......titWy.................
+ +++v G+++ ++C+as +++++i+Wy+++ + ++ + +
gi|1751120 246 SLrQVVFQGDRLPFQCsASylgndtRIRWYhnrapvegdeqagilla 292
.............LtI.nvtpeDsesgGtYtCaat..sgsasseqgttLt
+ ++ + ++ Lt++++ + s G+ C+++ g+as+ +++
gi|1751120 293 eslihdctfitseLTLsHIGVWAS---GEWECTVSmaQGNASK--KVEIV 337
Vl<-*
Vl
gi|1751120 338 VL 339
HormR: domain 1 of 1, from 342 to 419: score 11.0, E = 0.014
*->tdlgCpat....wDgiiCWpsTpaGqlvavpC......Peyfsgfsn
+ ++Cpa++ +++g Wp+T aG +++++C + + + + g +
gi|1751120 342 SASYCPAErvanNRGDFRWPRTLAGITAYQSClqypftSVPLGGGAP 388
ktggNrtqGnasRnCtedtGvGgWsepfpgaeSnrtWpnysnCtsndyee
t+ asR+C+ G+W++ +ys+C + + +
gi|1751120 389 GTR-------ASRRCDRA---GRWEP-----------GDYSHCLYTNDIT 417
lk<-*
+
gi|1751120 418 RV 419
ZU5: domain 1 of 1, from 606 to 717: score -52.5, E = 98
*->psflvs.....gtvdsrGGrLrgprHsGvrliiPpg.AipqGtryec
+++l+s + ++ ++ s+ ++L p Pp+ + ++
gi|1751120 606 SVALASiqlppSLFSSLPAALAPPV--------PPDcTLQLLVFRNG 644
YlvvhkklstpPPLDkee...gEtLLSPvvecGPCDVSmSAhGalllrPV
+l ++ ++ +P +++++ ++++Pv+ G S +G+ l+ PV
gi|1751120 645 RLFHSHSNTSRPGA--AGpgkRRGVATPVIFAGT---SGCGVGN-LTEPV 688
iLevpHC...Aslrprdkwelvllrsengg<-*
++++H ++A++ + w+ + ++g
gi|1751120 689 AVSLRHWaegAEPVAAW-WSQEGPGEAGGW 717
GPS: domain 1 of 1, from 699 to 751: score 21.0, E = 0.0035
*->snpiCvfWdese...tgeWstrGCelvetnkpthttCsCnHLTsFAv
+p ++W++ +++ g+W+++GC+l + + + C+HL++ Av
gi|1751120 699 AEPVAAWWSQEGpgeAGGWTSEGCQLRSSQP-NVSALHCQHLGNVAV 744
Lmdvspn<-*
Lm +s+
gi|1751120 745 LMELSAF 751
//
COG
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /data/patterns/cogs/cogs.hmm
Sequence file: tem9.fa
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
COG1380 -67.5 38 1
COG2832 -93.0 65 1
COG2245 -95.0 20 1
COG1280 -112.4 73 1
COG0730 -128.5 98 1
COG2860 -159.7 43 1
COG0472 -174.3 22 1
COG0531 -178.0 82 1
COG0628 -182.1 49 1
COG3302 -197.0 65 1
COG0038 -210.4 73 1
COG1575 -210.9 46 1
COG0609 -227.0 64 1
COG0591 -251.8 96 1
COG2899 -267.6 84 1
COG0534 -270.5 86 1
COG0651 -296.4 82 1
COG2814 -307.1 84 1
COG1178 -336.4 78 1
COG2995 -336.7 12 1
COG2233 -358.4 72 1
COG3135 -380.4 8.9 1
COG3333 -415.0 61 1
COG1009 -435.7 96 1
COG1138 -442.4 92 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
COG2814 1/1 589 860 .. 1 407 [] -307.1 84
COG2860 1/1 720 868 .. 1 225 [] -159.7 43
COG1380 1/1 758 870 .. 1 132 [] -67.5 38
COG3135 1/1 549 945 .. 1 560 [] -380.4 8.9
COG0609 1/1 768 947 .. 1 346 [] -227.0 64
COG1138 1/1 462 950 .. 1 706 [] -442.4 92
COG2832 1/1 799 954 .. 1 151 [] -93.0 65
COG0534 1/1 594 954 .. 1 482 [] -270.5 86
COG2245 1/1 743 957 .. 1 197 [] -95.0 20
COG3302 1/1 758 959 .. 1 329 [] -197.0 65
COG0591 1/1 371 966 .. 1 529 [] -251.8 96
COG0730 1/1 733 967 .. 1 287 [] -128.5 98
COG1575 1/1 726 991 .. 1 334 [] -210.9 46
COG1280 1/1 770 991 .. 1 214 [] -112.4 73
COG0651 1/1 657 1063 .. 1 534 [] -296.4 82
COG1178 1/1 620 1070 .. 1 615 [] -336.4 78
COG2899 1/1 820 1071 .. 1 371 [] -267.6 84
COG0472 1/1 744 1071 .. 1 432 [] -174.3 22
COG0038 1/1 738 1079 .. 1 486 [] -210.4 73
COG2233 1/1 732 1080 .. 1 509 [] -358.4 72
COG2995 1/1 646 1087 .. 1 525 [] -336.7 12
COG0628 1/1 738 1098 .. 1 381 [] -182.1 49
COG3333 1/1 732 1163 .. 1 519 [] -415.0 61
COG0531 1/1 660 1175 .. 1 537 [] -178.0 82
COG1009 1/1 738 1331 .] 1 701 [] -435.7 96
Alignments of top-scoring domains:
COG2814: domain 1 of 1, from 589 to 860: score -307.1, E = 84
*->masstkaqkskklallallaLAlaaFaiGttEFvpvGLLpdiAadlg
++ +++ +++ +++
gi|1751120 589 CTTGRPNVSLS---------------------------------SFH 602
v..siaaAGqLi..slYAlgvalgaPlLtlltarleRKrlLLgllalFiv
+++s+a+A +++sl++ a+ aP+ + + l++F
gi|1751120 603 IknSVALASIQLppSLFSSLPAALAPPVPPDCT---------LQLLVFRN 643
sNllsAlApnfalLllaRilsAlahGvFwviaaalAariVppekrgrAla
+ l + +R ++A p +rg A
gi|1751120 644 GRLFHSHSNT------SRPGAAG-----------------PGKRRGVATP 670
liftGltlAlvlGv..PLGtflGqlfGWRaaFlaiallallvllllarlL
+if+G++ v +++P + l ++ +a v+++ +
gi|1751120 671 VIFAGTSGCGVGNLtePVAVSLRHWA----------EGAEPVAAWWSQEG 710
PsipgsaraekpgslrsqlrllrrprvllillatilwigGhFtlYTYiaP
P +g + +s + qlr ++p+v ++ + G +
gi|1751120 711 PGEAG-----GWTSEGCQLRS-SQPNVSALH----CQHLGNVA------- 743
fLqevaGfsgatvtllLLvfGlagivGnllgGrladrlGprrtllgvlll
+L+e++ pr + ++ +l
gi|1751120 744 VLMELS------------------------------AF-PREVGGAGAGL 762
lalvlllLplaagslilalaalflWGlaafsagpalQtrvarlapRdaad
+ +v+ + +l+ +l+a+++ l ++r++ ++
gi|1751120 763 HPVVYPCTALLLL------------CLFATIITYILNHSSIRVSR-KGWH 799
vaaslnvaAfNlGialGAalGGlvldrglGlaalp.wvGAaLvllAllla
+ l + +f+++++ ++GG+ l++ ++++ ++vG L l ++
gi|1751120 800 M---LLNLCFHIAMTSAVFAGGITLTN---YQMVCqAVGITLHYSSLSTL 843
llaarskkktaaepsll<-*
l+ +++ +e +
gi|1751120 844 LWMGVKARVLHKELTWR 860
COG2860: domain 1 of 1, from 720 to 868: score -159.7, E = 43
*->rndtllttetlamlLsv..LyiIGitAFAmsGALlAgrekMDlFGVi
+ l + + ++L+ ++L ++++ + L+A ++
gi|1751120 720 EGCQLRSSQPNVSALHCqhLGNVAVLME-----LSAFPRE------- 754
vLasVTAiGG.GaiRDvLLGhyPlgALWvkhpeYliialvaavltvvvar
+GG Ga G P+ ++ l++ l+a +t ++
gi|1751120 755 -------VGGaGA------GLHPVV---YPCTALLLLCLFATIITYILNH 788
r.vrlmrl.lrklflvlDAiGLavFaiiGAqvAldmghsplIvvvaGviT
+ r+ r++++ l++++ +A+ + +v+aG iT
gi|1751120 789 SsIRVSRKgWHMLLNLC------------FHIAM------TSAVFAGGIT 820
GVGGGIlRDlLarriPLVLrkRDELYAtaAiagglvylllaeslglsatv
L+ Y ++ a g+++
gi|1751120 821 ------------------LTN----YQMVCQAVGITLHYS---------- 838
AllvtlfvglflRLlAiRfhWkLPtFrleeets<-*
+l +l g+ +R+l W+ P + e++
gi|1751120 839 SLSTLLWMGVKARVLHKELTWRAPP---PQEGD 868
COG1380: domain 1 of 1, from 758 to 870: score -67.5, E = 38
*->ltlmlkkvlrivrqlaiLfgflllGewiasllglpvPGSIvGmvlLf
+ l v+ +++l++L +f+ ++ i + + v+ + m+l
gi|1751120 758 AGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLL-- 802
lLLalgvvkleWveqgAslLlseMlLLFVPagVGVinYldllraeglpIl
L++ + ++ v +g+ L+ nY+ + +a g+ +
gi|1751120 803 -NLCFHIAMTSAVFAGGITLT---------------NYQMVCQAVGITLH 836
vvaivSTlivllvtGwivqllrklkkkkhrresel<-*
+ ++STl+ + v + + ++ + +++ ++++ +
gi|1751120 837 YS-SLSTLLWMGVKARVLHKELTWRAPPPQEGDPA 870
COG3135: domain 1 of 1, from 549 to 945: score -380.4, E = 8.9
*->mmvDGAFvRAEEAvSLNRLPSPiSK...NPAPAAHSDLRL..StCRD
+ AF R E v R SP +++ P P A LR + t R
gi|1751120 549 -LTCTAFQRREGGVPGTRPGSPGQNpppEPEPPADQQLRFrcTTGRP 594
ALElAifynvasvplfslliirPsialrtgraSasrevLlParerifla.
+ l f+ sv l s + Ps + a a+ P + l
gi|1751120 595 NVSLSSFHIKNSVALASIQLP-PSLFSSLPAALAPP--VPPDCTLQLLVf 641
rsdkvRvsFSlkRScsRqagklslVRlGCPGmLRdGeartlleittrepr
r ++ s S + sR + +
gi|1751120 642 RNGRLFHSHSNT---SRPGAAGP-------------------------GK 663
mRgFaddtpPsaLlAGfvAvlvGGGRvPAPYassavliGLSDwqAaGFqa
+Rg a + + AG + vG + +++ L w +
gi|1751120 664 RRGVA----TPVIFAGTSGCGVG------NLTEPVAVS-LRHWAEG---- 698
AGaspAQisSWLwalgvvmGvvgitLsLrYRvPivtAWSTPGaALLvaSl
a p ++ + g + G ++ + Lr +S
gi|1751120 699 --AEPVAAWWSQEGPGEAGGWTSEGCQLR------------------SSQ 728
ggltlaEaiGAFlVSaALitLcGvtapftRlmrkiPlsLAaALLAGiLLP
+ VSa+ +G a + l ++ P + A ++ L P
gi|1751120 729 PN-----------VSALHCQHLGNVAVLMEL-SAFPREVGGA--GAGLHP 764
FglkafaAleqqpaLvllmllsYLLakqfaPRYAVllaLlVGVvvaallG
+ Y ++Ll + + +++
gi|1751120 765 VV------------------------------YPCTALLLLCLFATIITY 784
qlhladlalkSLlavPewvtPeFSlaAlLslALPLfLvAmtSQnlPGiAv
l ++ + + lL+l +f +AmtS +G
gi|1751120 785 ILNHSSIRVS-----------RKGWHMLLNL---CFHIAMTSAVFAGGIT 820
LkAaGYRqaPpsPLlvaTGlASllaAPfGshsvnLAAIsAAICmgPdaHp
L ++ +++ l l +ll ++ + H
gi|1751120 821 LTNYQMVCQAVGITLHYSSLSTLLW---------MG------VKARVLH- 854
DkarRYtA........alwAGi....FYlLaGlFAaallgLfaaLPapll
k ++A++++++++al + +FYl+aG
gi|1751120 855 -KELTWRApppqegdpALPTPSpmlrFYLIAG------------------ 885
amLAGLALLgsimgsLqnAlkdereReGRGAAqPGSLAAlvaFaVTaSGf
G+ L i + +A + +R+ +V +
gi|1751120 886 ----GIPL---IICGITAAVNIHNYRD----------HSPYCWLVWRPSL 918
tLlgIGaAfWGLvaGlLaylvLnqiarRerg<-*
+ I A++ L++ + y+ ++ R rg
gi|1751120 919 GAFYIPVALI-LLIT-WIYFLCAG--LRLRG 945
COG0609: domain 1 of 1, from 768 to 947: score -227.0, E = 64
*->llllilllllllllsilslslGaisistfLfpsdvlqalfg..eqii
+ ++lll l++ ++ ++l+ +i++s + + +l++ + i
gi|1751120 768 PCTALLLLCLFATIITYILNHSSIRVS-----RKGWHMLLNlcFHIA 809
ldlRLPRilaallvGAsLAvaGailQgltRNPLAdPsiLGissGAalgav
++
gi|1751120 810 MT------------------------------------------------ 811
laillfpgasssslkrSvilnpyllplaAfiGaliaallvyllarrsggg
+ ++a++++l +y ++ +
gi|1751120 812 ----------------------------SAVFAGGITLTNYQMVC-QA-- 830
nslspirLiLaGvalsalfsAltslllylad.lqqvlfWll.....GSls
+G+ l + + + ++ ++a l++ l+W ++++++G+ +
gi|1751120 831 ----------VGITLHYSSLSTLLWMGVKARvLHKELTWRApppqeGDPA 870
ganWsdvllllpivllglilllllarkLnlLsLGddlAksLGvnverlrl
+ s l +i+ ++ ++++ G+
gi|1751120 871 LPTPSPMLRFYLIAGGIPLIIC-------------------GI------- 894
lllllvvlLtgaaVavaGpIgFvGLiaPHiaRllvGpdhrylLPlSaLlG
+ + ++r P++ L
gi|1751120 895 ------------------------------TAAVNIHNYRDHSPYCWL-- 912
alLLllADilaRtilaPaelPvGivTalilliGavaPyFlYLLrrrrkis
+ R l + +Pv ++ + yFl +r
gi|1751120 913 ---------VWRPSLGAFYIPVALILLIT------WIYFLCAGLRL---- 943
letrgrg<-*
rg +
gi|1751120 944 ---RGPL 947
COG1138: domain 1 of 1, from 462 to 950: score -442.4, E = 92
*->Mlp.elGn.....flLllAlllalllsll...plvGasrrdaklman
M+ ++lG+ ++ + l ++ a l l+++++l+ a+r d++ +
gi|1751120 462 MIQkFLGYvdqikELVEVMVDMASNLMLVdehLLWLAQREDKACSR- 507
niCLKFFPWiPCtsqvmlArpaayaqflllalAfllLvyaFltdDFSVqY
++++ + +l+ A v+a ++
gi|1751120 508 ----------------IVGALERIGGAALSPHAQHISVNA--------RN 533
VAaNSnseLPlyYKisAvWggHEGSLLLWvllLslwtflvalfsrklp..
VA ++ +P Y l ++ + + p++
gi|1751120 534 VALEAYLIKPHSY-------------------VGLTCTAFQRREGGVPgt 564
..................dtlkarvLAVmgLivlgFllfilftSNPFtrl
++++++++++++++++ ++ l++r +++ ++ + S F+
gi|1751120 565 rpgspgqnpppepeppadQQLRFR--------CTTGRPNVSLSS--FHIK 604
lPavPieGrdLNPlLQdvgLIfHPPLLYlGYVGfaVaFafa......vAs
v+ L + L PP L+ + ++++a a++ ++++ +
gi|1751120 605 N-SVA---------LASIQL---PPSLF---S--SLPAALAppvppdCTL 636
lLgGrldsawaRwsRpWtlvaWlFLTlGIvLGSWWAYyELGWGGwWFWDP
L R +R
gi|1751120 637 QLL------VFRNGR----------------------------------- 645
VENASLmPWLagtALlHSlavTeKRgsFkhWTvLLAilAFsLvLLGTFLV
L+HS + T + g +
gi|1751120 646 --------------LFHSHSNTSRPGAAGPG------------------K 663
RSGvlvSVHAFAsdpvRGvflLaflvlliggSLlLfalRapqvrEktisr
R Gv + V FA+ + Gv + l +++ SL a++a v
gi|1751120 664 RRGVATPV-IFAGTSGCGV---GNLTEPVAVSLRHWAEGAEPVA------ 703
lfdawsrvn...fellSrEgllLlnNillvvallvVllGTLyPlvvkllg
+ws+ ++++ ++ +Eg+ L + v+al lG + ++ +l++
gi|1751120 704 --AWWSQEGpgeAGGWTSEGCQLRSSQPNVSALHCQHLGNVA-VLMELSA 750
lgsQPPSisvGePFFnklFipLmlpllallGvGplvRWkraqpstlatLi
+ +vG + a +G+ p+v + +l L+
gi|1751120 751 FPR-----EVG----G-----------AGAGLHPVVY----PCTAL--LL 774
mLlviliaslVlaallifllgdtvnlasaLglaaaawvlLlllaellwrt
++l + i++++l + s + w +Ll+l + ++t
gi|1751120 775 LCLFATIITYIL-------------NHSSIRVSRKGWHMLLNLCFHIAMT 811
rgrvflvGkrkltrSqwgmiLaHlGvaliaiGiam..SglyssNQGYSEE
+ v++ g +L ++ a+Gi+++ S+l+ +
gi|1751120 812 SA----VFA-------GGITLTNYQMVCQAVGITLhySSLSTL------- 843
rdVrLaGEVSVpGqtvtlggytftfqqlkeeqgpNytsevAivdltregk
L +G+ + + +++t ++ ++g +
gi|1751120 844 ----LW-----MGVKARVLHKELTWRAPPPQEG-------------DP-- 869
NmmDEpiatLiPEkRfYvvegqsDrmteaaIdggllrDlYvalgeslrgn
+ t P RfY ++g + I+ g++ +a+ +
gi|1751120 870 -----ALPTPSPMLRFYLIAGG-----IPLIICGIT----AAVNIHNYRD 905
gswAvrlyykgPlvrWIWaGGEGlLMalGglLavtddrryrveveakkr<
s l+ + P ++ + ++L +l + + ++ +r+++ +
gi|1751120 906 HSPYCWLVWR-PSLGAFYIP--VALILLITWIYFLC-AGLRLRGPLAQN 950
-*
gi|1751120 - -
COG2832: domain 1 of 1, from 799 to 954: score -93.0, E = 65
*->mWTLDLCARRGlAyagirtpatqmvRylli..avGf......lsvvL
L LC + a +++y + +avG++ + ++ls++L
gi|1751120 799 HMLLNLCFHIAMTSAVFA-GGITLTNYQMVcqAVGItlhyssLSTLL 844
GiLGifLPvLPTTPFiLLAAACFarsSPRFyaWLlsh...........pv
+G+ vL + L + ++++++++ p+
gi|1751120 845 -WMGVKARVL--------------------HKELTWRapppqegdpalPT 873
fGpmvrdwqqggAvPrkaKvrAillivlsfai........SlwlvpvlWl
pm+r+++ g++P+ i i++++ i++ +++++ +wlv ++ l
gi|1751120 874 PSPMLRFYLIAGGIPLI-----ICGITAAVNIhnyrdhspYCWLVWRPSL 918
qvalllValvlvliym........wRvPtkeevAekqek<-*
+ Val l+++++ + ++R P +++
gi|1751120 919 GAFYIPVALILLITWIyflcaglrLRGPLAQ---NPKAG 954
COG0534: domain 1 of 1, from 594 to 954: score -270.5, E = 86
*->gsirkaLlkralrLAiPiilanllqtlyglvDtfmvGhlgGadaLA.
+ ++ i +++++++l +++ + + ++aLA+
gi|1751120 594 PNVSLSSFH---------IKNSVALASIQLPPSLFSS--L-PAALAp 628
..AVglaspilflliaig.mglgtGtsvlvaQaiGAgdregarraarqgl
+ + ++l + + + + + +a G g+r+g++ + +
gi|1751120 629 pvPPDCTLQLLVFRNGRLfHSHSNTSRPGAA---GPGKRRGVA----TPV 671
vllalllslllgllglfllellLrllg............aseevlalAae
++ a ++ +g l+ + + l ++ + ++ +++ ++e ++++e
gi|1751120 672 IF-AGTSGCGVGNLTEPVAVSLRHWAEgaepvaawwsqeGPGEAGGWTSE 720
YLrililglpfallsfvlrgalrgaGdtrtpmvvsiignllNivLdyiLI
+ lr+ + ++ +gn++ +L
gi|1751120 721 ------------------GCQLRSSQPNVSALHCQHLGNVA------VLM 746
fGkg.vlFGfpglGivGAAiATviarwigflvllfyllrgkkgllislfd
+ + G++GA++ +++ +++l+ll ++ + + l +++
gi|1751120 747 ELSAfP----REVGGAGAGLHP-VVYPCTALLLLCLFATIITYILNHSS- 790
rvlkllkpdrkvlkkllrlGflPialeeilfsvgsfllntlfvarfGtda
++ +rk + ll+l + ia + +++ g+++l+ + +
gi|1751120 791 -----IRVSRKGWHMLLNLC-FHIAMTS-AVFAGGITLTNYQMVCQ---- 829
vAAyqialriaslifmppfGisiAvttlvGqnlGAgnyerarraarlglk
A +i+l +sl+ + ++G+ ar ++
gi|1751120 830 --AVGITLHYSSLSTLLWMGV------------------KARVLHKE--- 856
lslliglilalllllfpepiasllftsdpevialaaqlllilaisqpfdl
l++ +p+p + dp+ + + l+++ ++
gi|1751120 857 -----------LTWRAPPPQEG-----DPA----LPTPSPMLRFYLIAG- 885
FvgiqvvlsGvlrGaGdtkvpliislisywgirlPlayllafftgfgknf
gi ++ G+ + +++ +++ + P ++l ++
gi|1751120 886 --GIPLIICGITAA---VNIHNYRDHS-------PYCWLVWRP------- 916
wllltglglaGvWlgliignlvaaiigvvlallwrllrrwrkgteaaaek
+ G + + ++ +++ ++ + + + + + +g a+ +k
gi|1751120 917 --------SLGAFYIPVAL-ILLITW-----IYFLCAGLRLRGPLAQNPK 952
aa<-*
a
gi|1751120 953 AG 954
COG2245: domain 1 of 1, from 743 to 957: score -95.0, E = 20
*->vikMeLsnAKl.lgGiGaiLqLvGaavgllGiLiwiLSivGlVLvLi
+ MeLs + + gG Ga G ++++ + ++ l L L
gi|1751120 743 AVLMELSAFPReVGGAGA-----GLHPVVY----PCTAL--LLLCLF 778
alymISkqvgddrIFnyyLigfismvaglilfvivifAtvGvsivallkk
a +I + + ++I + +g m++ l ++ + A v++ + l+
gi|1751120 779 A-TIITYILNHSSI-RVSRKG-WHMLLNLCFHIAMTSA-VFAGGITLTNY 824
smmslahglaalgsiLaGfViLyIayiigtyFqk....Ks..........
m+ a g+++ s L +L ++ + + k+ + ++++++++++
gi|1751120 825 QMVCQAVGITLHYSSLS---TLLWMGVKARVLHKeltwRApppqegdpal 871
........yEliAqyTgVdmFrtAGLl..........Yfi.......Gai
+++++ ++ liA+ + +++ + ++ +++++Y + +++ Ga
gi|1751120 872 ptpspmlrFYLIAGGIPLIICGITAAVnihnyrdhspYCWlvwrpslGAF 921
LLIVlGvGflilliAaILeiVaFFSLPdEikaseqaaVsp<-*
+ V+ lilli +I + a L+ +++ +a s
gi|1751120 922 YIPVA----LILLITWIYFLCAGLRLRGPLAQNPKAGNSR 957
COG3302: domain 1 of 1, from 758 to 959: score -197.0, E = 65
*->MgpGwhEwPLvfFTVlaQcvvGafIVtyfillltkngkgqGLPrqrv
g G+h+ V ++ ++ ++ i +n + rv
gi|1751120 758 AGAGLHPV------VYPCTALLLLCLFATIITYILNHSS-----IRV 793
lksMfilliLmGiGFIASimHLGsPlRAFnSLnRvGaSaLSRNEIAsGaI
+ + +l+ + +H a+ ++++G I
gi|1751120 794 SRKGWHMLLNL-------CFHI----------------AMT-SAVFAGGI 819
FFtlgGliWLvAilgkmspaLgklWlIvTmiLGilFvwmmamVYasIdtV
t + + +a g + l + + l + + a+V +
gi|1751120 820 TLTN---------YQMVCQAVGIT-LHYSSLSTLLWMGVKARVL-HKE-- 856
PtWnngiTvlsFfLtvllgGSSAFpiLsYalLlpakvteyfltfLpvlsv
+tW G A p+ s + l+f + +
gi|1751120 857 LTWRAPPPQ---------EGDPALPTPSPM-----------LRFYLIAGG 886
LglviaaiVRQFYIKRPtvlqGlnLahI..hSsRVqqasaLVPnYatlev
+ l+i++i + n ++ ++hS Y+ l v
gi|1751120 887 IPLIICGIT-----------AAVNIHNYrdHSP-----------YCWL-V 913
wRvvLLqvlPTFIPLAYLftwiiPllllrepYVTDVVnvpLLvlsylLiL
wR L + ++ p V++ LL + + L
gi|1751120 914 WRPSLGA--------------------FYIP-----VALILL-ITWIYFL 937
aGEaIGRWCFFVEGNHVQvLFYGLHMtvGmaiag<-*
+ + R G Q+ + G a+
gi|1751120 938 CAGLRLR------GPLAQN------PKAGNSRAS 959
COG0591: domain 1 of 1, from 371 to 966: score -251.8, E = 96
*->nliillifliYlvlvllIGwyayrrtksgseleDYylaGRslgpfvv
+ f + ++ + G+ a+rr + aGR
gi|1751120 371 QSCLQYPFTSVPLGGGAPGTRASRRCDR---------AGR------- 401
alslgatymSaatflGlpGaaYasGlgglwyaigyligalilallvaprl
++S Y++ + ++y + + + +al +a l
gi|1751120 402 ---WEPGDYS--------HCLYTNDITRVLYTFVLMPINASNALTLAHQL 440
rklsekknnalTipDflaaRfgsk..skllRilsalviivfflpYlaaQl
r+++ + a ++ D++ + + k+l ++ + +v ++ +a++l
gi|1751120 441 RVYT-AE--AASFSDMMDVVYVAQmiQKFLGYVDQIKELVEVMVDMASNL 487
vGgglllevlf..idyetgivigalivilYtflG................
+ + l l+++ d + ++gal i +l+++ ++ + + ++ +
gi|1751120 488 MLVDEHLLWLAqrEDKACSRIVGALERIGGAALSphaqhisvnarnvale 537
..................................................
++++ + + + ++++++ +++++++++++++++++++ +++ +
gi|1751120 538 aylikphsyvgltctafqrreggvpgtrpgspgqnpppepeppadqqlrf 587
..............HGmkavawTDviQgilmlvalivlpvvvllkgGfge
+ ++++++ + ++ H i+ + l+ + ++p
gi|1751120 588 rcttgrpnvslssfH----------IKNSVALASIQLPPSLFSSL----- 622
afealaaalpl...............................alggsgmv
+ ++ + p+ + + ++++ ++++++++++ +++++ + +
gi|1751120 623 PAALAPPVPPDctlqllvfrngrlfhshsntsrpgaagpgkrRGVAT--- 669
iaiisiilllawgfGvlglPhilvRffaaksakelrlkailiggfwgily
++i+ + + g+G l+ P + + a a+ ++ ++++ + +
gi|1751120 670 -PVIF-AGTSGCGVGNLTEPVAVSLRHWAEGAEPVA---AWWSQEGPGEA 714
llaaaliGlaaialvgdgpaadmavglvpadnaqnnWsemvfpalivall
+ + + G ++ ++++a l + v ++ ++++
gi|1751120 715 GGW-TSEGCQLRSSQPNVSA------LHCQHL------GNVAVLMELSAF 751
ppeALvwlaGfllaailAAimSTadsqLlvassaftrDiYkrvirkgkna
p + G + a+l + ++ ++Ll + a i++++++
gi|1751120 752 PR----EVGG--AGAGLHPVVYPCTALLLLCLFAT---IITYILN----- 787
sekklvrvsRiavlllgvialllAllppgnpvvldlvglafgglgaaflp
+ ++rvsR l + + +A++ + +++ + + + +a +
gi|1751120 788 --HSSIRVSRKGWHMLLNLCFHIAMTSAV--FAGGITLTNYQMVCQAVGI 833
vl....llgLyWkRatk................................w
l+ ++l +L W + ++ +++ + + ++++++++ +++++ + +
gi|1751120 834 TLhyssLSTLLWMGVKArvlhkeltwrapppqegdpalptpspmlrfylI 883
gAiaGmiaGlltvil................yeivPglfvslvafllgsw
+ ++ i ++t++++ ++ +++++ +++ ++++ ++++ll+
gi|1751120 884 AGGIPLIICGITAAVnihnyrdhspycwlvwRPSLGAFYIPVALILLI-- 931
kak.A.afivvslltkvvasefelkmpaaapvgtrvqdrfeaaakavpaa
+ + ++ + l ++ +a+ p ++ +a ++ ++
gi|1751120 932 -TWiYfLCAGLRLRGP----------LAQNP-----KAGNSRASLEAGEE 965
k<-*
+
gi|1751120 966 L 966
COG0730: domain 1 of 1, from 733 to 967: score -128.5, E = 98
*->mmnlalllllflvGfiaGflaglfGiGGGl..llvPaLlflgglpph
+++ l ++++ + +f + G G+Gl++++ P +l+ l
gi|1751120 733 ALHCQHLGNVAVLMELSAFPREVGGAGAGLhpVVYPCTALLL-L--- 775
vAvGTsllqvlftalssayahlkkgnvdlklglilglgsvvGaalGalla
+ ++ ++ l+ + + ++ + l l + +++ ++ G ++
gi|1751120 776 ----CLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITL 821
klipaeikyeaLklifgllllllalymllskkieikpkreekpnkkslpl
++g+ l +++l +ll + k +++ ++l
gi|1751120 822 TNYQMVC------QAVGITLHYSSLSTLLWMGV--------KARVLHKEL 857
pglggfyepleieyavrawlliliGfliGflsGllGiGGGsllvPaLill
++ + + G +l +P +l
gi|1751120 858 TWRAPPPQE----------------------------GDPALPTPSPMLR 879
lgyslplkkavgtsllaialsslisfllyl....lggpvdwllalglvlG
+ + +a g+ l++ ++++++ +y +++++ v w+ lg+ +
gi|1751120 880 F-----YLIAGGIPLIICGITAAVNIHNYRdhspYCWLV-WRPSLGAFYI 923
siiGaylGarlasrkligprflrllfalilllvalklllkglgmll<-*
++ ++l +++ + +lr ++a + + l++ +l+
gi|1751120 924 PVALILLITWIYFL--CAGLRLRGPLAQNPKAGNSRASLEAGEELR 967
COG1575: domain 1 of 1, from 726 to 991: score -210.9, E = 46
*->mNQttksemtaasmasarlqiWleaaRPkTLpaAlaPvvvGtaLAyw
Q + s + + ++ + e ++++P vG +++++
gi|1751120 726 SSQPNVSALHCQHLGN--VAVLME--------LSAFPREVG-GAGAG 761
lggkfdllva..vLaLltAilLqIlsNlANDYgDavkGtDtedRvGplRl
l++++ + a +L+L+++i Il ++ +++
gi|1751120 762 LHPVVYPCTAllLLCLFATIITYIL---------------NHSSIR---- 792
ivsglitpkevllasifsvalavLsGlvLvlvagdnLadlwtllgLGlla
+++k ++++++ +a+ s v+ +g +L + ++
gi|1751120 793 -----VSRKGWHMLLNLCFHIAMTSA---VFAGGITLTNYQ------MVC 828
IaagytYTGGpkPlGYlGLGdlsVfifFGpLa.Vl...GsyYlQtAAHLA
a g+t l Y +L s ++ +G+ a+Vl+++ ++ +
gi|1751120 829 QAVGIT-------LHYSSL---STLLWMGVKArVLhkeLTW--RA----- 861
GAFPvAiPPgriswalllpS..ipvGilataiLlvNNlRDiEeDakaGKk
PP+ ++al +pS+ + ++a+ i l+ +G+
gi|1751120 862 ------PPPQEGDPALPTPSpmLRFYLIAGGIPLI----------ICGI- 894
TLaVRLGdkrarqlyaaLlv..vAyaavlgfvlataapwwvfLvfLlslP
T aV + +r y+ L+ ++++ a ++ +l + + w fL ++
gi|1751120 895 TAAVNIHNYRDHSPYCWLVWrpSLGAFYIPVALILLITWIYFL----CAG 940
lavrvakqVfqk..........eDqPrelapaladtvklslltnlLfavG
l +r +++ q+++ ++++ + e +++el+ + + + ll+ +++
gi|1751120 941 LRLR--GPLAQNpkagnsraslE-AGEELRGSTRLRGSGPLLSD---SGS 984
lllgqLr<-*
ll+ + +
gi|1751120 985 LLATGSA 991
COG1280: domain 1 of 1, from 770 to 991: score -112.4, E = 73
*->mmdmsfllafligslalslalsPGPdnllvlsn.slkyGfraGllaa
a+l+ +l++++ +++l ++s++ ++++ +++
gi|1751120 770 -------TALLLL--CLFATI-----ITYILNHsSIRVSRKG--WHM 800
LGlalGdavhvlLaalGlaaL....lktspllFtlLkllGAaYLlYLGvq
L + + ++ ++++G +L++ +++ + ++ +L++ + Ll++Gv+
gi|1751120 801 LLNLCFHIAMTSAVFAGGITLtnyqMV-CQAVGITLHYSSLSTLLWMGVK 849
m........lrskgkkleases..aasplsrswklflrG...........
++ +++ ++r + +++e++ + +++sp r ++l +++ + + +
gi|1751120 850 ArvlhkeltWR-APPPQEGDPAlpTPSPMLR---FYLIAggipliicgit 895
lltnllN.....PKaiLFfl.sllpqFidpqaslaslaqllvlgaiivlv
+++n+ N ++++P+ +L + +sl++ +i+++ l + +++ + +++
gi|1751120 896 AAVNIHNyrdhsPYCWLVWRpSLGAFYIPVALILL----ITWIYFLCAGL 941
dllwfsllAllgsrlarllrsnprfqrvlnrlaGl..lLigfGvklllsr
l + ++ +++ l + r+ rl G+++lL +G +l++ +
gi|1751120 942 RLRGPLAQNPKAGNSRASLEA-GEELRGSTRLRGSgpLLSDSGSLLATGS 990
l<-*
gi|1751120 991 A 991
COG0651: domain 1 of 1, from 657 to 1063: score -296.4, E = 82
*->Msalvll....lillPLvaafllpillllgllgpfagltliallali
+ + +++++ +++P+++a + +g ++ ++ +l +
gi|1751120 657 --GAAGPgkrrGVATPVIFAGTS----GCGVGNLT-EPVAVSLRHWA 696
vllvllgyvlltglgalvggtlGgwlap......................
++ +++++++ ++ +g gw + + + ++++++ + + ++ ++
gi|1751120 697 EGAEPVAAWWSQEGPGEAG----GWTSEgcqlrssqpnvsalhcqhlgnv 742
.................fgivlelDplsalfllilalvgllvslYsigym
+ + +++ ++ + g++ ++ p al ll l + + + + +
gi|1751120 743 avlmelsafprevggagAGLHPVVYPCTALLLLCL-FATIITYILNHSSI 791
rrekgrgedsaavyyallllllagmlGafltgDlfnlyVFfEimalaSya
r+ + + + l l ++ +m+ a+++g + +l+ y
gi|1751120 792 RVSRKG------WHMLLNLCFHIAMTSAVFAGGI----------TLTNYQ 825
LvalggtkealeaglkYlvlggvgsalfLlGigllYaatGTLnfadlaav
+v +Gi l Y+ TL ++++a+
gi|1751120 826 MVCQ------------------------AVGITLHYSSLSTLLWMGVKAR 851
lls............glalaaflLlliGfgvKaglFPLHfWLPdAyseAp
l ++ + + +++++g ++ + f + ag PL
gi|1751120 852 VLHkeltwrapppqeGDPALPTPSPMLRFYLIAGGIPL------------ 889
spiSAllSgvvvKvGvYaliRvllllfgglgideq.elipaslgalllil
+ +G ++ ++ ++ d+ ++ + +++ l ++
gi|1751120 890 -----------IICG------ITAAVNIHNYRDHSpYC-WLVWRPSLGAF 921
aaltaifGvlmAllqsDiKRLLAYSsvsQmGyIllglgiGtpgidlgplt
yI ++l++ +
gi|1751120 922 -------------------------------YIPVALILLIT-------- 932
alalaaalfHllnHalfKglLFLgAGaviyrtGtrdldklgGLakrmPll
++ FL+AG +l+G + ++P +
gi|1751120 933 ------WIY------------FLCAGL-----------RLRGPLAQNP-K 952
talafliaalslaGiPplnGFvSKwliiqallaaggsapvg.lpllavll
+ + a+l+ag +l + l
gi|1751120 953 AGNS------------------------RASLEAG-----EeLRGSTRLR 973
lvgsaitfayfvrllykffgggflgaPrsetepgakeapllmllpmlil.
g +++ + ++ ++ g+++ +++ + p+++l + ++++
gi|1751120 974 GSGPLLSDSGSLLATGSARVGTPG----PPEDGDSLYSPGVQLGALVTTh 1019
allclllGvapepvlkalgapaaallliytvkvsavlaglpdiai<-*
+l+ +++ + +v+++ + +++ +y+v sa++ +++ +
gi|1751120 1020 FLYLAMWACGALAVSQRWLP-RVVCSCLYGVAASALGLFVFTHHC 1063
COG1178: domain 1 of 1, from 620 to 1070: score -336.4, E = 78
*->vvasly.v.m.ysaillvlavgalatla.....tvklvvmggdplri
++ + ++ l+l v++ ++l++++++t++ + g+ + r
gi|1751120 620 SSLPAAlApPvPPDCTLQLLVFRNGRLFhshsnTSRPGAAGPGKRR- 665
glwlliglllaalllllppl.v.lavlalsafsgglaeflavlsdayllr
g++ +++++ ++ + l+ ++av+++ +++g + a++s+ ++
gi|1751120 666 GVATPVIFAGTS-GCGVGNLtEpVAVSLRHWAEG-AEPVAAWWSQEGPGE 713
llgnTLllallvTvlslilGlplAyllsrydfPGrrwlrwllaLPiLLvi
g+T + r + + aL
gi|1751120 714 AGGWT-----------------------SEGCQLRSSQPNVSALH----C 736
PalvvAfgfislfGksGwLarllgelfGlssreywlpdiygPlgGiilal
+l + ++ l + + gG+ +l
gi|1751120 737 QHLGNVAVLMELS-----------------------AFPRE-VGGAGAGL 762
vlfnyPlvyllaaaalesidpsleEaArsLGasrwqvFrrVtLPllrPai
+ yP ll++ + +i + L++s ++v r+
gi|1751120 763 HPVVYPCTALLLLCLFATIIT------YILNHSSIRVSRK---------- 796
aagalLvFlyclsdFgavliLGGspqytTlttaIyqeilgs.qldlatAa
g + +c+ ++++++ G+ +t+ yq + ++ + l +++
gi|1751120 797 --GWHMLLNLCFHIAMTSAVFAGG-----ITLTNYQMVCQAvGITLHYSS 839
lLallLLllsllllwvvvkllerfsrgrqkvyssgqswarpiprilllgl
l ll +++ + +l e+ +r+ + +++ ++
gi|1751120 840 LSTLLWMGVKARVLH-----KELTWRA----PPPQ---EGDPALPTPSPM 877
aalvallfclllfsvlllgvilplsflllWtvlltsdewsdamlgplfst
+ ++++++ +l+ +g++ +++ +++ s
gi|1751120 878 LRFYLIAGGIPLI---ICGITAAVN-------IHNYRDHS---------- 907
sfwhalinsLtlallAalialllaLllaylvrrsrsrlsrfidrLsmLpl
++ + + +l+A++i ++l Ll+ + +
gi|1751120 908 ---PYCWLVWRPSLGAFYIPVALILLITWIYFLC---------------- 938
AvPGvVlalGllllfnnldnhwvdlaameGvkpllvlygtllllVlAyal
Gl l + + n + ++ + l + l
gi|1751120 939 --------AGLRLRGPLAQN--------------PKAGNSRASLEAGEEL 966
ralPfalrsleaalrqidprLeeaArsLGasrwqifrrvtLP........
r + +s p L++++ L ++ rv +P++++++++
gi|1751120 967 RGSTRLRGSG--------PLLSDSGSLLATGSA----RVGTPgppedgds 1004
LllpgllaAaalvFalsmkElsATllLgppdftTLttaiynylsggdgry
L pg+ +a++ +T +L+ + ++a+ + r+
gi|1751120 1005 LYSPGVQLGALV----------TTHFLYLAMWACGALAV-------SQRW 1037
aaAavllvasaAlvLvlislllfvllikrygersqgt<-*
++ v++ +l v++s+l ++++ + ++ r++ +
gi|1751120 1038 ----LPRVVCSCLYGVAASALGLFVFTHHCARRRDVR 1070
COG2899: domain 1 of 1, from 820 to 1071: score -267.6, E = 84
*->MktfReFrGfSlLvTvvcLalAawdGYaRGGHTllalanALfLlvvL
t+ + vc a++ Y+ l L++ v
gi|1751120 820 --TLTNYQ-------MVCQAVGITLHYS-------SLSTLLWMGVKA 850
avLEVSLSF........DNAViNAaiLkrMSefWqklFLtiGILIAVFGM
vL L + ++++++D A L + S+ + GI
gi|1751120 851 RVLHKELTWrapppqegDPA------LPTPSPMLRFYLIAGGI------- 887
RLVFPivIVavtaGLglvevmklALenPAHGALEFADGSesYeklLtkah
P++I +ta v + P Y l+
gi|1751120 888 ----PLIICGITA---AVNIHNYRDHSP-------------YCWLVWR-- 915
paIAAFGGmFLLmvFLdFlvdndrdlhWLkPiErpLAriGklDaVqaViv
p+ G+F + v L l+ W + L G l + +
gi|1751120 916 PSL----GAFYIPVALILLIT------WIYFLCAGLRLRGPLAQNPKAGN 955
avaLllatkLfvapaeqfqdvLiAGLvGllv....YLvvdaidrlFktdg
+ a l a+ + + ++ G l+++++ L+ + r +
gi|1751120 956 SRASLEAGEELRGSTRLRG-------SGPLLsdsgSLLATGSARVGTPGP 998
lGEAtPevqvaqkAgkAGvAaFLYLEVLDAsFSfDGViGAFAiTkDvViI
Pe++ D +S
gi|1751120 999 -----PEDG-------------------DSLYS----------------- 1007
alGLGviGAmFVRSiTvyLVrkgTLdeYvFLEHGAHYAIGaLAVImLlSi
G GA+ +T + +L A +A GaLAV S
gi|1751120 1008 -PGV-QLGAL----VTT---------HFLYL---AMWACGALAV----SQ 1035
drrfhVPEvVT.glvGva..fIaaAlweSlrrnrrevls<-*
r+ P vV + l Gva + ++ + ++rr v+
gi|1751120 1036 --RW-LPRVVCsCLYGVAasALGLFVFTHHCARRRDVRA 1071
COG0472: domain 1 of 1, from 744 to 1071: score -174.3, E = 22
*->MLlmLa.llpalsslnlfsYltafrallalliafllsllltpifipf
L +L + + + ++ + ++ +a+ll l+++i++++
gi|1751120 744 VLMELSaFPR--EVGGAGA--G-LHPVVYPCTALLLLCLFATIITYI 785
lrklaikigqdirkdgpksHkshKagTPtmGGlaIllsflivlslllwag
l+++ i+++ ++ ++++ h a T a++++ + + +
gi|1751120 786 LNHSSIRVSRKGWHMLLNLCF-HIAMT-----SAVFAG------GITLTN 823
lnsganpyevevwlvLlvllgfgliGflDDlfklsrKnnkGLsakiKlll
+ + + ++G+ + +ls + ll+
gi|1751120 824 YQ-------M----------VCQAVGITLHYSSLS-------T----LLW 845
qfiaAvlllilllkfdgslltqlyiPFfkspsfdlgtllylvlavfalVg
+ A +l l +++ +P ++p+++ + ++ f+l++
gi|1751120 846 MGVKARVL-HKELTWRAP------PPQEGDPALPTP----SPMLRFYLIA 884
ssNAvNltDGLDGLAaGlsviaalalaliaylsgnvnfAqYLlipyipda
+G+ +i+++ a + + d+
gi|1751120 885 ---------------GGIPLIICGITAAVNIHNYR-------------DH 906
gelailclalaGAcLGFLwfNfyPGkAkvFMGDtGSlaLGavlgalavll
++ ++l + P +LGa+ +a++l
gi|1751120 907 SPYCWLVW--------------RP-------------SLGAFYIPVALIL 929
klklqei...................................lllimggv
++ i + + +++ ++++ ++++ + + +++ ++++ l g+
gi|1751120 930 L--ITWIyflcaglrlrgplaqnpkagnsrasleageelrgsTRLRGSGP 977
fvietlsvilqvlsrklr......kd.pt.igkrifkmaplHhHfelkgw
++ + s +++ r+ ++++++++d++ ++g + H+ ++ +++
gi|1751120 978 LLSDSGSLLATGSARVGTpgppedGDsLYsPGVQLGALVTTHFLYLAMWA 1027
glkftlrqflifiilcaigiLislslrllreakvvvrfWiislilaligl
++++ +q r+ ++vv++++ + + al
gi|1751120 1028 CGALAVSQ------------------RW--LPRVVCSCLYGVAASALGLF 1057
atlllaavgvllavifaflrfviwlklrl<-*
++++ + ++ +r+
gi|1751120 1058 VFTH---------------HCARRRDVRA 1071
COG0038: domain 1 of 1, from 738 to 1079: score -210.4, E = 73
*->frfetsstpllrkvflrllsgrailigviagllavalllalilvggv
+ + + l + + r + g agl++v+++ ++ l++ +
gi|1751120 738 HLGNVAVLMELSAFP-RE------VGGAGAGLHPVVYPCTALLLLCL 777
vgalaagvlalgvavgeglrlvlaagplkvlllplvvalggSallalisg
+ ++ + +++ + + + ++ + +l +++ ++++g g
gi|1751120 778 FATIITY-ILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAG--------G 818
llvykfapeaaGsGipqviealhgnegGqipwrvlvvKilaslltigsGg
+ + +++ + +Gi + +l+ + ++ +++ v++
gi|1751120 819 ITLTNYQMVCQAVGITLHYSSLSTLL--WMGVKARVLH------------ 854
SlGREGPsvqiGaalgsalgkllklkgadedrrtrlliaaGaAAGlAAaF
l+ + + +e
gi|1751120 855 ----------------KELTWRAPPP--QEGDPA---------------- 870
naPLAGalFiaEvlyrrfllvtallpalvasavaavivlvfgfnlfgfdp
+ +l + l++ + +++ +++++v ++n ++d+
gi|1751120 871 ------------LPTPSPMLRFYLIAGGIPLIICGITAAVNIHN--YRDH 906
lfslpiaasltvplldlplyillGifaGlaG.vlfvrllyklhalfrrlk
+ l + lG+f ++ +l++ ++y l a++r +
gi|1751120 907 SPYCW-----------LVWRPSLGAFYIPVAlILLITWIYFLCAGLRLRG 945
lppvlklvigGlliGgsvvllalllPevlggGyglvqlvfagnlsltspa
p + g + ++ l ++ e g + ++ ++
gi|1751120 946 -PLAQNPKAGNSRAS----LE--AGEELRGSTRLRGSGPLLSDSGSL--- 985
gllleilllLfvaKilaTslsygsGapGG......lfaPslaiGatlGra
+ + s+ +G pG ++++++l+ P++++Ga++ +
gi|1751120 986 ----------------LATGSARVGTPGPpedgdsLYSPGVQLGALVTTH 1019
fgllvavllfpaisvspgifalaGMaaflaattraPLTaillvlEmTGny
f ++M a+ a + ++
gi|1751120 1020 FL-------------------YLAMWACGA---------------LAVSQ 1035
tllpplLiacliasliaqllggkpiytiyaertlgrqnaeaeager<-*
+ lp ++cl ++ ++l + +t++ +r+++++ + ++ ++
gi|1751120 1036 RWLPRVVCSCLYGVAASALGLF--VFTHHCARRRDVRASWRACCPP 1079
COG2233: domain 1 of 1, from 732 to 1080: score -358.4, E = 72
*->m.llatalrsvllsmsdsampstmtksdlvygvddrp.pllkllllG
+ l + l+ v +m sa p+ + g+ ++ p llll
gi|1751120 732 SaLHCQHLGNVAVLMELSAFPREVGG--AGAGLHPVVyPCTALLLLC 776
LQHllAMFgatVlVPLivGlalgLaaedlayLIsmsLfasGiaTLlQtli
L F+ +++ ++ +++ ++ ++
gi|1751120 777 L------FATIITY-ILNHSSIRVS----------------------RKG 797
tgRpfGiglPivLGsSFAFvgPmIaaGglgkegGadieaamgGifgaglv
++ ++ L A +++ a+ g + +++ + ++ ++
gi|1751120 798 WH------MLLNLCFHIAMTSAVFAG---GITL-TNYQMVCQAVGITLHY 837
ygviglLisrfgtgdrLkrlfPPvVtGpVImvIGLsLapVAikmagGgea
+++ +lL +++ + L++ ++ + + +
gi|1751120 838 SSLSTLLWMGVKAR-VLHKELT---------------------WRAPPP- 864
amasgnpdfgslenLlLalvVLliilllnrfgkGflrlipILiGlvvGYv
+++ al + +++lr + I G+ +
gi|1751120 865 QEGDP------------ALPT----------PSPMLRFYLIAGGIPL--I 890
lAlfmGlvdfdsalveaap...wfalPtpfyfGaPYtpaFnwgaIltmlp
++ + v+ + +++p +++ P++ +f + ++Il +
gi|1751120 891 ICGITAAVNI-HNYRDHSPycwLVWRPSLGAF------YIPVALILLITW 933
valv.........tivEhvGditAtgkvtgkpllgPeYkpgLhrG..lla
++ + + + +++++ + ++ + +g l g ++L+++++ll
gi|1751120 934 IYFLcaglrlrgpLAQNPKAGNSRASLEAGEELRG---STRLRGSgpLLS 980
DGlatllAGl..fGgfPnTTFaqNiGvvalTgVaSryVivwaAvililLG
D+ + l++G ++G+++ + +S+ V
gi|1751120 981 DSGSLLATGSarVGTPGPPEDGDS--------LYSPGV------------ 1010
lfPKfaallqsIPsPVLGGamivlFGmIAasGiriLirakvdlsknRNLl
++al+++ ++ + +++ + s +R L
gi|1751120 1011 ---QLGALVTT-----------------HFLYLAMWACGALAVS-QRWLP 1039
IvAvsLglGlGgaavPpeflaglPavlrplllsGialgaitAIvLNllLp
v +s G+ ++a+ ++ + + +
gi|1751120 1040 RVVCSCLYGVAASAL-G-LFVFTH-------------------------H 1062
grrrnpiveerreeksvtaeaaeealkkea<-*
rr+ ++a +a ++ a
gi|1751120 1063 -------CARRRD-----VRASWRACCPPA 1080
COG2995: domain 1 of 1, from 646 to 1087: score -336.7, E = 12
*->mFLSRYFTiLYRiGiLSNGFGSRRTTAqKiFLPDTKGLFiLPNLPVL
+F S T R G + G G RR A + T G + NL
gi|1751120 646 LFHSHSNT--SRPG--AAGPGKRRGVATPVIFAGTSGCGV-GNLT-- 685
HPDWV.YRLFSFimPPlilatppmtP.......kaklthhAlrGNCCdEl
P V+ R ++ P + + P++ ++ ++ + +++
gi|1751120 686 EPVAVsLRHWAEGAEPVAAWWSQEGPgeaggwtSEGCQLRSSQ------- 728
lpgklilCpeCdllidvPrldqsaqsAeCPRCGhkLtrggrwplsrpaAl
+ + C + + + +l+ A+ PR +gg p+ +
gi|1751120 729 PNVSALHCQHLGNVAVLMELS-----AF-PR-----EVGGAGAGLHPVVY 767
AlacLiLm.pfSlgfPyl....sisl..lGvtieatL...legiwllvee
++L+L+ +f+ +y+ +++si++++ G ++L + + + + +
gi|1751120 768 PCTALLLLcLFATIITYIlnhsSIRVsrKGWHMLLNLcfhIAMTSAVFAG 817
gYalLAllvFfcvilaPllflllvlylwlaarlkqaRqLsssEvqklRll
g l+ + +++ l + l +lw + + v ++l
gi|1751120 818 GITLTNYQMVCQAVGITLHYSSLSTLLWMGVKAR---------VLHKELT 858
ll.........vLvrLKeWvMvDVFLVgvlVsliKlkdyAeiei......
+ ++++++++ L + + M+ +L++ + li A + i++ +++
gi|1751120 859 WRapppqegdpALPT--PSPMLRFYLIAGGIPLIICGITAAVNIhnyrdh 906
Gpsllpfv....lfalLtvlllskvdvrwLWeeFqPAetelgqnakqvhv
p+ + +v +++l a ++l+++ + W +F A+ l+ ++ q
gi|1751120 907 SPYCW-LVwrpsLGAFYIPVALILLIT---WIYFLCAGLRLRGPLAQNPK 952
eiksGLvSCsaChyirtqKsllyPdqqkgvCpRCgskLyvRrpnLsLqwt
++s +++ + g +R +++L+ + p+ L+ +
gi|1751120 953 AGNS--------RASL----------EAGEELRGSTRLRGSGPL--LSDS 982
wAlLlAaIilyfPANLLPImiiyllGareedTIlsGVisLwkeGsypVAa
lL ++ + + + + ed sL + G + A+
gi|1751120 983 GSLLATG------------SARVGTPGPPEDG-----DSLYSPGVQLGAL 1015
VIFlASIlVPvlKiiamayLlasaGkfklqtgqknLkrmllYRvvefvGR
V +yL + a ++l ++q+ ++ ++
gi|1751120 1016 V------------TTHFLYLAMWA-CGALAVSQR--WLPRV--------- 1041
WSMiDlFVIailmsLVqrgqilaftpGpaAlyFgaVViLTMLSAevFDpR
+++ G aA + g+ V+ T A D R
gi|1751120 1042 ------------VCSCL--------YGVAASALGLFVF-THHCARRRDVR 1070
LLWDe..pdsseaefne<-*
+W + p+ s+a+
gi|1751120 1071 ASWRAccPPASPAAPHA 1087
COG0628: domain 1 of 1, from 738 to 1098: score -182.1, E = 49
*->mlmspairrllkpvvlrllvlllillllll..flylfqplllplllA
+l a++++l+ +++ + +++ l++++y + lll+ l+A
gi|1751120 738 HLGNVAVLMELS-----AFPREVGGAGAGLhpVVYPCTALLLLCLFA 779
lvlayllnPvvrwLerklgipRplavllvllllllllallllllvptlv.
+++y+ln ++ r +g + l ++ +++ +++a +l +++v
gi|1751120 780 TIITYILNHSSIRVSR-KGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVc 828
gidqlgqlirnnlPqlnnllqqllawlpnig...................
+ + ++ ++l++l++++ ++ ++ + ++++++++ +++++
gi|1751120 829 QAVGITLHY-SSLSTLLWMGVKARVLHKELTwrapppqegdpalptpspm 877
...llqlslyasldeliqqlisnrlaailgsilssllnllgrqvknllgl
+ +l+++ ++ + i+++++ i ++ s + +l+ + + + +
gi|1751120 878 lrfYLIAGGIPLIICGITAAVN-----IHNYRDHSPYCWLVWRPSLGAFY 922
ivslllvllllfffLldgeklkegilsllPsrlyrprvkrilselnaslg
i +l++l++ ++fL g +l+ +++ + + + ++ +el+ s +
gi|1751120 923 IPVALILLITWIYFLCAGLRLRGPLAQNPK-AGNSRASLEAGEELRGSTR 971
nyirGqvlvaliiGvlsgigllllgvpy............alllallagl
+rG+ + G l + g + +g p++++++++ +++ l+al++
gi|1751120 972 --LRGSGPLLSDSGSLLATGSARVGTPGppedgdslyspgVQLGALVTTH 1019
lnlIPyiGaviiwiPaliyalltggglatwggllvlivflviqqlednvL
+ y+ ++ ++ + l + + l+++++ + ++
gi|1751120 1020 F---LYLAMWAC---GALAVSQRW--L-PRVVCSCLYGVAAS--ALGLFV 1058
rPklmgkrlgLhPllillsllgGgslfGfvGlilgpPllavlkalldayl
+r + + a ++a
gi|1751120 1059 FTHHCARRRD-------------------------------VRASWRACC 1077
rgdia.eli.fkklaeqlgeees<-*
+ a+++ ++ ++++ + e+
gi|1751120 1078 PP--AsPAApHAPPRALPAAAED 1098
COG3333: domain 1 of 1, from 732 to 1163: score -415.0, E = 61
*->MemldsllQGlslvleptNLllmlIGvlvGil...VGlLPGLGpina
+l ++L+ + + + ++++VG+ a
gi|1751120 732 ------------SALHCQHLGNVAVLMELSAFpreVGG--------A 758
vALllPlTFALGlpPstAlILlagVYlGalyGGSIsSILlNiPGepSsVa
A l P+ + P tAl+Ll +l+ I+ IL Ss+
gi|1751120 759 GAGLHPVVY-----PCTALLLL------CLFATIITYIL-----NHSSIR 792
TafDGYPMArkGqAGkALalsayaSfi..GalvsallLlFlsPqlAkfAL
G+ M + +++++++ +G ++ ++ + + L
gi|1751120 793 VSRKGWHMLLN----LCFHIAMTSAVFagGITLTNYQMVCQAVGI---TL 835
aFgspEYFaLmLfaltivaGmsGqGsplK...tLlaavlGlllatVGiDk
+s l+++ m + ++l ++ t+ a +
gi|1751120 836 HYSS----------LSTLLWMGVKARVLHkelTWRAPP-----------P 864
vsGvlRFTFdqtfLlsGisFillviGLFaisEILlqveKrrekrsAnEqE
G++ + ++ L + +i i L I ++ +
gi|1751120 865 QEGDPALPTPSPMLR--FYLIAGGIPL-----IICG------------IT 895
rakntgrmrlRtwkelaevllviLRSsllGfimGVlPGaGaTiASFlsYs
+a+n+ r + + +lv+ R sl f + V T Fl +
gi|1751120 896 AAVNIHNYRD----HSPYCWLVW-RPSLGAFYIPVALILLITWIYFLCAG 940
larr..lskkAkkeEFGnGsleGvaAPEtAnnaa...tggalvPMLTLGv
l r++l+ +++ Gn s ++ A E ++++ +++g P+L
gi|1751120 941 LRLRgpLAQ--NPKA-GN-SRASLEAGEELRGSTrlrGSG---PLLS--- 980
PGSgtTAVMLGALliyGl....qPGPqLFveqpDiVWglIaSmyvgNvvl
+ G Ll+ G + ++PGP e +D ++ + +g v
gi|1751120 981 --DS------GSLLATGSarvgTPGPP---EDGDSLYS--PGVQLGALVT 1017
l.IvnlplvrlFakiLavPssvLlPvIlmfclIGvYaVhystlDVylMi.
+ + l++ + Lav s lP ++ cl Y+V +s l +++ +
gi|1751120 1018 ThFLYLAM--WACGALAV-SQRWLPRVVCSCL---YGVAASALGLFVFTh 1061
.......lfGliGYlLrKlgFPlaPLLLGfILGglaEenLRrALviSdGe
+ +++++ + + + P aP L aE+ + v+ +G
gi|1751120 1062 hcarrrdVRASWRACCPPAS-PAAPHAPPRALPAAAEDG---SPVFGEGP 1107
LsilWe......rPlaLtftiLaivmLLlPLlrRCAkAldrRvkr...Ra
s +++++++ PlaL+ L + L + A+A +++++
gi|1751120 1108 PSLKSSpsgssgHPLALGPCKLTNLQLAQSQVC-EAGAAAGGEGEpepAG 1156
TGtkaek<-*
T+ +++
gi|1751120 1157 TRGNLAH 1163
COG0531: domain 1 of 1, from 660 to 1175: score -178.0, E = 82
*->ssalrkkLGlwdlvalgigamiG..aGifalpgtaaalag..paail
+ +r+ ++ +a + g +G+ + +a+ + +a ++++ aa++
gi|1751120 660 GPGKRRGVATPVIFAGTSGCGVGnlTEPVAVSLRHWAEGAepVAAWW 706
a.....wllaglivlliAlsyaelssaiapelslaGGvYtYarralG...
++++++ + ++ + s +sa+ + + G + + ++
gi|1751120 707 SqegpgEAGGWTSEGCQLRSSQPNVSAL-HC-Q-HLGNVAVLMELSAfpr 753
fagfltgwlyllsyiigpaiialaavsyl.slfpggfgasfgialptwlg
+g + l+ + y ++ + + ++++ +++++ + s+ + +w+
gi|1751120 754 EVGGAGAGLHPVVYPCTALLLLCLFATIItYILNH---SSIRVSRKGWHM 800
illggaqvlivivllllftllnllGvklsgrlntigteSkrvalivipll
+l + ++ +++t +++G ++++++ ++++ i l
gi|1751120 801 LLNL--------CFHIAMTSAVFAGGITLTNYQMV------CQAVGITLH 836
ifillgiilfasglgfvtanflgpsgngifvdVlpg...glagpgfggvl
l +++ + ++ + ++ p++++++a p +++l
gi|1751120 837 YSSLSTLLWMGVKARVLHKELTWRA--------PPPqegDPALPTPSPML 878
agailvg.iffaFvGfeavatlaeEvknP.............erniPrAi
+++g+i + G+ a+++ ++ ++ +++ ++ iP A+
gi|1751120 879 RFYLIAGgIPLIICGITAAVN-IHNYRDHspycwlvwrpslgAFYIPVAL 927
ilsllivgliYilvsvalvgggdwsevvpsselas.saapangrkvanvf
i lli+ + ++++ + l g + ++ a++s a
gi|1751120 928 I--LLITWIYFLCAGLRLRG------PLAQNPKAGnSRAS---------- 959
alavaatallGwgaiiisvgallsllgsllawilsasRvlyamArdGilP
++a l G ++ g lls +gslla+ + Ar G
gi|1751120 960 --LEAGEELRG-STRLRGSGPLLSDSGSLLAT---------GSARVGTPG 997
k.....ffskvnprfrisltPvialiltgilsallallfplvslafsvlt
++++++++ ++++t + +++++++al l ++ s l
gi|1751120 998 PpedgdSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLY 1047
llaflavllaylvlrialkklkpdlrrpgkkekkafrrpgvg..vlpilg
+a a+ l ++ + +a+ ++d+r+++++ + ++ p++++ +l
gi|1751120 1048 GVAASALGLFVFTHHCAR---RRDVRASWRACC-PPASPAAPhaPPRALP 1093
ialclya.llyssglp............................lilgvi
+a+ ++++ +++ +++++++++++ ++ + ++ + ++ ++ ++
gi|1751120 1094 AAAEDGSpVFGEGPPSlksspsgssghplalgpckltnlqlaqsQVCEAG 1143
lvalGllilyllyarklpsdqsrlilssflhkkevedeeveevlepelas
+a G + + + + + ++
gi|1751120 1144 AAAGG-EGEPEPAGT--------------RGNL----------AHRHPNN 1168
aeakaav<-*
+++ +++
gi|1751120 1169 VHHGRRA 1175
COG1009: domain 1 of 1, from 738 to 1331: score -435.7, E = 96
*->mmmnlllliillPllgalvlllfggrsrlirktggllagvfslllvl
+ n + l+ l+ a+ +g + +g +++ + ++l
gi|1751120 738 HLGNVAVLMELS----AFPREVGG------AGAGLHPVVYPC--TAL 772
sallsallillflgqggseaaihqslftWlpagnlginfgfyiDgLsllM
++l+ + +i+ +++++ s + + + ++ l +n+ f+i s+++
gi|1751120 773 LLLCLFATIITYILNHSS----IRVSRKGWHM--L-LNLCFHIAMTSAVF 815
llvVtgvglLihiYSigYMadedegkdygRFfayLlLFtasMLgLVlSDN
+ +t+ +++
gi|1751120 816 AGGITL---------------TNYQ------------------------- 825
LLllflgWEgvGLcSYLLIGFWysrpkamFfpskaAkkAFlvtRvGDlgl
+ ++
gi|1751120 826 ---------------------------M-------------------VCQ 829
LlGiilLyltfGtlsiselfeaassldaagiqvl.g..............
+ Gi l y+ tl + + + + + +++++++++++ ++++
gi|1751120 830 AVGITLHYSSLSTLLWMGVKARVLHKELT----WrApppqegdpalptps 875
.....hvGveslltlilLllllGAfgKSAQfPlHtWLpdAMEGPTPVSAL
+ + + ++++i L + + +
gi|1751120 876 pmlrfY----LIAGGIPLIICG------------------------IT-- 895
lHAATMVtAGVYLvaRlsplfep..........yL.lspvalyl.valvG
A ++ +++ +++++ + + s a+y++val+
gi|1751120 896 ---AAVN-------------IHNyrdhspycwlVWrPSLGAFYIpVALIL 929
avTallgaliAlvQnDiKriLAYSTiSQLGyMflalGlg..........g
++T ++ fl +Gl +++ ++++
gi|1751120 930 LITWIY--------------------------FLCAGLRlrgplaqnpkA 953
AysaAifHLitHAfFKAlLFLsaGsvihamhtrqnDirkmGG........
+ s A + +++++++ ++++G+++ +++
gi|1751120 954 GNSRASL---------------------EAGEELRGSTRLRGsgpllsds 982
......................LrkyMPvtavafliGsLaLaGvPPftsG
++ +++ + +++++++++++L++ P + +++l+ t +
gi|1751120 983 gsllatgsarvgtpgppedgdsLYS--PGVQLGALV-----------TTH 1019
FfSKdeIleaalasghlllsnvptwgflaplllligallTafYsfRllfl
F+ ++ +ala+++ +l ++ + l+ ++ s+++lf+
gi|1751120 1020 FLYLAMWACGALAVSQRWL-----------PRVVCSCLYGVAASALGLFV 1058
vFhG......eperheaerhylHaldddvliaHpHeapgvmlnfylPliv
+ h+ ++++ +++ a p+ +p + + P+
gi|1751120 1059 FTHHcarrrdVRASWRAC--------------CPPASPAAPH---APPRA 1091
LavlslllGvffpillstwlpapllavaelgeelpggLahitllvlalls
L +++ + p++ ++ + l +++ g ++ La + l+ l
gi|1751120 1092 LPAAAEDGS---PVFGEGPPS---LKSSPSGSSGHP-LALGPC-KLTNLQ 1133
lalaivGillall.mylgakllptkiyl.............lepfrflyk
la + v+ + a+ + + + + +t +l ++++++ ++++++ + r+ +
gi|1751120 1134 LAQSQVCEAGAAAgGEGEPEPAGTRGNLahrhpnnvhhgrrAHKSRAKGH 1183
llynkyyldklYdglfvkvglliarlldavldkyliDygivnavgr....
+ ++ + ++l + + ++ ++++ ll + l ++ + +++g ++++
gi|1751120 1184 RAGEACGKNRL--KALRGGAAGALELLSSE-SGSLHNSPTDSYLGSsrns 1230
..................................................
++ + + ++++ +++++++++ + ++ ++ +++++ ++++ ++++ +
gi|1751120 1231 pgaglqlegepmltpsegsdtsaaplseagragqrrsasrdslkgggale 1280
.........alvtlfsrGavlrrtqsGylrahYalslvlGavlllailvs
+++++++ + ++ ++ + ++ ++ ++ + ++ G + ++
gi|1751120 1281 keshrrsypLNAASLN--GAPKGGKYDDVT-LMGAEVASGGCMKTGL--- 1324
galflvrrl<-*
+ + +
gi|1751120 1325 --WKSETTV 1331
//
hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file: /data/patterns/cogs/cogs.hmm-f
Sequence file: tem9.fa
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query: gi|17511205|ref|NP_116166.6| tumor endothelial marker 5 precursor [Homo sapiens]
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
COG0842 4.3 3.9 1
COG1532 2.2 51 1
COG1659 1.4 20 1
COG3216 0.3 25 1
COG1176 0.3 55 1
COG0052 0.1 52 1
COG1901 -0.4 34 1
COG0750 -0.5 55 1
COG2969 -0.8 86 1
COG1132 -1.5 89 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
COG1532 1/1 125 137 .. 46 58 .. 2.2 51
COG0750 1/1 137 153 .. 487 503 .] -0.5 55
COG2969 1/1 173 179 .. 163 169 .] -0.8 86
COG1659 1/1 587 600 .. 273 286 .] 1.4 20
COG0842 1/1 753 795 .. 324 365 .] 4.3 3.9
COG1132 1/1 768 796 .. 1 32 [. -1.5 89
COG3216 1/1 843 859 .. 141 157 .. 0.3 25
COG1901 1/1 900 911 .. 295 306 .] -0.4 34
COG1176 1/1 910 924 .. 237 251 .. 0.3 55
COG0052 1/1 1028 1039 .. 95 106 .. 0.1 52
Alignments of top-scoring domains:
COG1532: domain 1 of 1, from 125 to 137: score 2.2, E = 51
*->GkvvkiDLdehkI<-*
G+++++DL ++I
gi|1751120 125 GELKRLDLSNNRI 137
COG0750: domain 1 of 1, from 137 to 153: score -0.5, E = 55
*->lllmllltfndiprlla<-*
++++ + tf+++prll+
gi|1751120 137 IGCLTSETFQGLPRLLR 153
COG2969: domain 1 of 1, from 173 to 179: score -0.8, E = 86
*->psLRVVK<-*
p+L+VV+
gi|1751120 173 PALKVVD 179
COG1659: domain 1 of 1, from 587 to 600: score 1.4, E = 20
*->sriktaeAililSs<-*
+r+ t ++ + lSs
gi|1751120 587 FRCTTGRPNVSLSS 600
COG0842: domain 1 of 1, from 753 to 795: score 4.3, E = 3.9
*->Rylllg.aglsdvwfsllvLallgllllllgllllrrrekkar<-*
R++ + +agl +v++ + +L+ll+l++ ++ ++l + +++ r
gi|1751120 753 REVGGAgAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSR 795
COG1132: domain 1 of 1, from 768 to 796: score -1.5, E = 89
*->lillllglfllgvaravlsylqryllarvgqr<-*
+ ll+l+l++ +++y+ ++ +rv+ +
gi|1751120 768 PCTALLLLCLFA---TIITYILNHSSIRVSRK 796
COG3216: domain 1 of 1, from 843 to 859: score 0.3, E = 25
*->awLmqrpgrpfsdeLtW<-*
++ m++ +r ++ eLtW
gi|1751120 843 LLWMGVKARVLHKELTW 859
COG1901: domain 1 of 1, from 900 to 911: score -0.4, E = 34
*->vhnhLDrlgaps<-*
+hn++D+ ++
gi|1751120 900 IHNYRDHSPYCW 911
COG1176: domain 1 of 1, from 910 to 924: score 0.3, E = 55
*->clLVFiPAlGsfviP<-*
c+LV P+lG+f+iP
gi|1751120 910 CWLVWRPSLGAFYIP 924
COG0052: domain 1 of 1, from 1028 to 1039: score 0.1, E = 52
*->cGmfYVngRWLG<-*
cG+ +V++RWL+
gi|1751120 1028 CGALAVSQRWLP 1039
//