analysis of sequence from tem5 ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ >gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWA GDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWA LVSPETPPTPGALRRRRKVPPSGSGGSEFSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSL SPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSR RGELAGPGFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNF HLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAPPSAEAKPP EAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEI FDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARP AFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINK GVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRK SGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKL SESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEFPHPDARLGFE QAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSL RAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPG PQPCLHISIAGSGLEMTPGLGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSK EATAETTSSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWL GTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVT LGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHV CLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTV SCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRGPAPARPK MLVISGGDGYEDFRLSSGGGSSSETVGRDDSTNHLLLWRV ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ sec.str. with predator > gi|2224615|dbj|BAA20795.1| . . . . . 1 MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQ 50 ________________EEEE_____________HHHHHHHHHHHHHHHHH . . . . . 51 RMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPE 100 HH__________________________HHHHH_________________ . . . . . 101 PPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTP 150 __EEEEE_______________________________EEEE________ . . . . . 151 GALRRRRKVPPSGSGGSEFSNGEAGEAYRSLSDPIPQRHRAATSEEPTGF 200 _HHHHHH_________EEE_______EEEE______HHHHHHHH______ . . . . . 201 SVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSI 250 __________________________________________HHHHHHHH . . . . . 251 VQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV 300 H_________HHHHH_______________________________EEE_ . . . . . 301 EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNF 350 __________HHHHHHH_________HHHHHHHHHH______________ . . . . . 351 HLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPS 400 ______EEE____EEE__________HHHHHHH_________________ . . . . . 401 SRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSL 450 _____________EEEEE_________EEEE___________________ . . . . . 451 EDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAPPSAEAKPPEAARPADEPT 500 _HHHHHHHHHH_______________________________________ . . . . . 501 PASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV 550 _________HHHHHHHHHHHHH_HHHHHHHHHHHHHHHH_________EE . . . . . 551 LCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS 600 E____HHHHHHH_HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE____ . . . . . 601 KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALS 650 __HHHHHHHHH______HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH . . . . . 651 DLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINK 700 HHH___EEE_HHHHHHHHHHHH__________HHHHHHHHHHHHHHHHH_ . . . . . 701 GVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGK 750 __HHHHHHHHHHHHHHHHHHHHH___HHHHHHHHHHHHHHHHHHH_____ . . . . . 751 KDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKL 800 ___EEEEE__EEEE____________________EEEEHHHHHHHHHH__ . . . . . 801 PLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQS 850 _____EEEEHHHHHHHHHHHHHHHHHHH______________________ . . . . . 851 LDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEF 900 HHHHHHHHHHHHHHH_HHHHHHHHH_______EEEEE________EEEE_ . . . . . 901 PHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAA 950 _____HHHHHHHHHHHHHHHHHH________EEEEEEEE_______EEE_ . . . . . 951 PTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCI 1000 ____________EEEE____EEEEHHHHHHH_____EEEEHHHHHEEEE_ . . . . . 1001 GAVPGLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPG 1050 ________________________________HHHHHHHHHHHHHH____ . . . . . 1051 PQPCLHISIAGSGLEMTPGLGEGDPRPELVPFDSDSDDESSPSPSGTLQS 1100 ___EEEEEE___________________EEE___________________ . . . . . 1101 QASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLPLSGSFGPGGPC 1150 __________________________________________________ . . . . . 1151 GTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVY 1200 ________EEEE__________HHHHH_________EEEEE____EEEEE . . . . . 1201 QSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHF 1250 E____HHHHHHHHHHHHHH___EEEE____EEEEE____EEEEE______ . . . . . 1251 WDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMF 1300 ______EEEE_______EEEEE____EEE____EEEEEE____HHHHHEE . . . . . 1301 YVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPV 1350 EE______EEEEEE______EEEE___EEEEE____HHHHHHHH______ . . . . . 1351 HRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTV 1400 EEEE_______HHHHHHHHHHHHHHHHHHHHEEE____EEEEE_______ . . . . . 1401 SCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDTGPEKL 1450 __________________HHHHHHHH_______EEE______________ . . . . . 1451 PSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSSGGGSSSETVGRDD 1500 ____________________EEEE______EEEE________________ . 1501 STNHLLLWRV 1510 _HHHHHH___ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ method : 1 alpha-contents : 37.2 % beta-contents : 0.0 % coil-contents : 62.8 % class : alpha method : 2 alpha-contents : 10.0 % beta-contents : 0.0 % coil-contents : 90.0 % class : irregular ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ GPI: learning from metazoa -20.28 -2.95 -1.11 -0.32 -4.00 0.00 0.00 0.00 -1.11 -9.32 -2.76 -12.00 -12.00 -4.00 -12.00 0.00 -81.85 -5.92 -1.83 -1.58 -2.52 0.00 0.00 -16.00 0.00 -0.38 -9.32 -2.76 -12.00 -12.00 -4.00 -12.00 0.00 -80.31 ID: gi|2224615|dbj|BAA20795.1| AC: xxx Len: 1470 1:I 1457 Sc: -80.31 Pv: 7.847467e-01 NO_GPI_SITE GPI: learning from protozoa -13.38 -2.06 -1.53 -1.49 -4.00 0.00 -16.00 0.00 -0.05 -7.95 -9.85 -12.00 -12.00 -4.00 -12.00 0.00 -96.31 -25.88 -1.89 -0.85 -1.52 -4.00 0.00 0.00 0.00 -0.36 -8.90 -9.85 -12.00 -12.00 -4.00 -12.00 0.00 -93.25 ID: gi|2224615|dbj|BAA20795.1| AC: xxx Len: 1470 1:I 1452 Sc: -93.25 Pv: 7.551621e-01 NO_GPI_SITE ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ # SignalP euk predictions # name Cmax pos ? Ymax pos ? Smax pos ? Smean ? gi|2224615| 0.539 488 Y 0.497 1388 Y 0.862 1377 N 0.082 N # SignalP gram- predictions # name Cmax pos ? Ymax pos ? Smax pos ? Smean ? gi|2224615| 0.676 488 Y 0.395 488 Y 0.979 6 Y 0.128 N # SignalP gram+ predictions # name Cmax pos ? Ymax pos ? Smax pos ? Smean ? gi|2224615| 0.559 488 Y 0.490 488 Y 0.978 7 Y 0.182 N ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ low complexity regions: SEG 12 2.2 2.5 >gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] 1-8 MARRLPRT salksssselll 9-20 21-56 TGPGAEEDPLPLIVQDQYVQEARQVFEKIQ RMGAQQ ddgsdappgspd 57-68 69-161 WAGDVTRGQRSQEELSGPESSLTDEGIGAD PEPPVAAFCGLGTTGMWRPLSSSSAQTNHH GPGTEDSLGGWALVSPETPPTPGALRRRRK VPP sgsggsefsngeage 162-176 177-281 AYRSLSDPIPQRHRAATSEEPTGFSVDSNL LGSLSPKTGLPATSAMDEGLTSGHSDWSVG SEESKGYQEVIQSIVQGPGTLGRVVDDRIA GKAPKKKSLSDPSRR gelagpgfegpggep 282-296 297-334 IREVEPMLPPSSSEPILVEQRAEPEEPGAT RSRAQSER alpealpppata 335-346 347-477 HRNFHLDPKLADILSPRLIRRGSKKRPARS SHQELRRDEGSQDQTGSLSRARPSSRHVRH ASVPATFMPIVVPEPPTSVGPPVAVPEPIG FPTRAHPTLQAPSLEDVTKQYMLNLHSGEV PAPVPVDMPCL plaappsaeakppeaarpadeptpa 478-502 503-565 SKCCSKPQVDMRKHVAMTLLDTEQSYVESL RTLMQGYMQPLKQPENSVLCDPSLVDEIFD QIP ellehheqfleq 566-577 578-766 VRHCMQTWHAQQKVGALLVQSFSKDVLVNI YSAYIDNFLNAKDAVRVAKEARPAFLKFLE QSMRENKEKQALSDLMIKPVQRIPRYELLV KDLLKHTPEDHPDHPLLLEAQRNIKQVAER INKGVRSAEEAERHARVLQEIEAHIEGMED LQAPLRRFLRQEMVIEVKAIGGKKDRSLFL FTDLIVCTT lkrksgslrrssmsl 767-781 782-1011 YTAASVIDTASKYKMLWKLPLEDADIIKGA SQATNRENIQKAISRLDEDLTTLGQMSKLS ESLGFPHQSLDDALRDLSAAMHRDLSEKQA LCYALSFPPTKLELCATRPEGTDSYIFEFP HPDARLGFEQAFDEAKRKLASSKSCLDPEF LKAIPIMKTRSGMQFSCAAPTLNSCPEPSP EVWVCNSDGYVGQVCLLSLRAEPDVEACIA VCSARILCIGAVPGLQPRCH repppslrsppetapepagpeldveaaade 1012-1048 eaatlae 1049-1082 PGPQPCLHISIAGSGLEMTPGLGEGDPRPE LVPF dsdsddesspsps 1083-1095 1096-1099 GTLQ sqasrstisss 1100-1110 1111-1113 FGN eetpsskeataettsseeeqepgflplsgs 1114-1149 fgpggp 1150-1436 CGTSPMDGRALRRSSHGSFTRGSLEDLLSV DPEAYQSSVWLGTEDGCVHVYQSSDSIRDR RNSMKLQHAASVTCILYLNNQVFVSLANGE LVVYQREAGHFWDPQNFKSVTLGTQGSPIT KMVSVGGRLWCGCQNRVLVLSPDTLQLEHM FYVGQDSSRCVACMVDSSLGVWVTLKGSAH VCLYHPDTFEQLAEVDVTPPVHRMLAGSDA IIRQHKAACLRITALLVCEELLWVGTSAGV VLTMPTSPGTVSCPRAPLSPTGLGQGHTGH VRFLAAVQLPDGFNLLC ptpppppdtgp 1437-1447 1448-1485 EKLPSLEHRDSPWHRGPAPARPKMLVISGG DGYEDFRL ssgggsss 1486-1493 1494-1510 ETVGRDDSTNHLLLWRV low complexity regions: SEG 25 3.0 3.3 >gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] 1-1 M arrlprtsalkssssellltgpgaeedplp 2-32 l 33-135 IVQDQYVQEARQVFEKIQRMGAQQDDGSDA PPGSPDWAGDVTRGQRSQEELSGPESSLTD EGIGADPEPPVAAFCGLGTTGMWRPLSSSS AQTNHHGPGTEDS lggwalvspetpptpgalrrrrkvppsgsg 136-186 gsefsngeageayrslsdpip 187-274 QRHRAATSEEPTGFSVDSNLLGSLSPKTGL PATSAMDEGLTSGHSDWSVGSEESKGYQEV IQSIVQGPGTLGRVVDDRIAGKAPKKKS lsdpsrrgelagpgfegpggepirevepml 275-344 ppsssepilveqraepeepgatrsraqser alpealpppa 345-403 TAHRNFHLDPKLADILSPRLIRRGSKKRPA RSSHQELRRDEGSQDQTGSLSRARPSSRH vrhasvpatfmpivvpepptsvgppvavpe 404-444 pigfptrahpt 445-465 LQAPSLEDVTKQYMLNLHSGE vpapvpvdmpclplaappsaeakppeaarp 466-509 adeptpaskccskp 510-663 QVDMRKHVAMTLLDTEQSYVESLRTLMQGY MQPLKQPENSVLCDPSLVDEIFDQIPELLE HHEQFLEQVRHCMQTWHAQQKVGALLVQSF SKDVLVNIYSAYIDNFLNAKDAVRVAKEAR PAFLKFLEQSMRENKEKQALSDLMIKPVQR IPRY ellvkdllkhtpedhpdhpllle 664-686 687-1001 AQRNIKQVAERINKGVRSAEEAERHARVLQ EIEAHIEGMEDLQAPLRRFLRQEMVIEVKA IGGKKDRSLFLFTDLIVCTTLKRKSGSLRR SSMSLYTAASVIDTASKYKMLWKLPLEDAD IIKGASQATNRENIQKAISRLDEDLTTLGQ MSKLSESLGFPHQSLDDALRDLSAAMHRDL SEKQALCYALSFPPTKLELCATRPEGTDSY IFEFPHPDARLGFEQAFDEAKRKLASSKSC LDPEFLKAIPIMKTRSGMQFSCAAPTLNSC PEPSPEVWVCNSDGYVGQVCLLSLRAEPDV EACIAVCSARILCIG avpglqprchrepppslrsppetapepagp 1002-1056 eldveaaadeeaatlaepgpqpclh 1057-1060 ISIA gsglemtpglgegdprpelvpfdsdsddes 1061-1173 spspsgtlqsqasrstisssfgneetpssk eataettsseeeqepgflplsgsfgpggpc gtspmdgralrrsshgsftrgsl 1174-1436 EDLLSVDPEAYQSSVWLGTEDGCVHVYQSS DSIRDRRNSMKLQHAASVTCILYLNNQVFV SLANGELVVYQREAGHFWDPQNFKSVTLGT QGSPITKMVSVGGRLWCGCQNRVLVLSPDT LQLEHMFYVGQDSSRCVACMVDSSLGVWVT LKGSAHVCLYHPDTFEQLAEVDVTPPVHRM LAGSDAIIRQHKAACLRITALLVCEELLWV GTSAGVVLTMPTSPGTVSCPRAPLSPTGLG QGHTGHVRFLAAVQLPDGFNLLC ptpppppdtgpeklpslehrdspwhrgpap 1437-1466 1467-1474 ARPKMLVI sggdgyedfrlssgggsssetvgrdds 1475-1501 1502-1510 TNHLLLWRV low complexity regions: SEG 45 3.4 3.75 >gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] 1-38 MARRLPRTSALKSSSSELLLTGPGAEEDPL PLIVQDQY vqearqvfekiqrmgaqqddgsdappgspd 39-105 wagdvtrgqrsqeelsgpessltdegigad peppvaa 106-227 FCGLGTTGMWRPLSSSSAQTNHHGPGTEDS LGGWALVSPETPPTPGALRRRRKVPPSGSG GSEFSNGEAGEAYRSLSDPIPQRHRAATSE EPTGFSVDSNLLGSLSPKTGLPATSAMDEG LT sghsdwsvgseeskgyqeviqsivqgpgtl 228-523 grvvddriagkapkkkslsdpsrrgelagp gfegpggepirevepmlppsssepilveqr aepeepgatrsraqseralpealpppatah rnfhldpkladilsprlirrgskkrparss hqelrrdegsqdqtgslsrarpssrhvrha svpatfmpivvpepptsvgppvavpepigf ptrahptlqapsledvtkqymlnlhsgevp apvpvdmpclplaappsaeakppeaarpad eptpaskccskpqvdmrkhvamtlld 524-946 TEQSYVESLRTLMQGYMQPLKQPENSVLCD PSLVDEIFDQIPELLEHHEQFLEQVRHCMQ TWHAQQKVGALLVQSFSKDVLVNIYSAYID NFLNAKDAVRVAKEARPAFLKFLEQSMREN KEKQALSDLMIKPVQRIPRYELLVKDLLKH TPEDHPDHPLLLEAQRNIKQVAERINKGVR SAEEAERHARVLQEIEAHIEGMEDLQAPLR RFLRQEMVIEVKAIGGKKDRSLFLFTDLIV CTTLKRKSGSLRRSSMSLYTAASVIDTASK YKMLWKLPLEDADIIKGASQATNRENIQKA ISRLDEDLTTLGQMSKLSESLGFPHQSLDD ALRDLSAAMHRDLSEKQALCYALSFPPTKL ELCATRPEGTDSYIFEFPHPDARLGFEQAF DEAKRKLASSKSCLDPEFLKAIPIMKTRSG MQF scaaptlnscpepspevwvcnsdgyvgqvc 947-1182 llslraepdveaciavcsarilcigavpgl qprchrepppslrsppetapepagpeldve aaadeeaatlaepgpqpclhisiagsglem tpglgegdprpelvpfdsdsddesspspsg tlqsqasrstisssfgneetpsskeataet tsseeeqepgflplsgsfgpggpcgtspmd gralrrsshgsftrgsledllsvdpe 1183-1510 AYQSSVWLGTEDGCVHVYQSSDSIRDRRNS MKLQHAASVTCILYLNNQVFVSLANGELVV YQREAGHFWDPQNFKSVTLGTQGSPITKMV SVGGRLWCGCQNRVLVLSPDTLQLEHMFYV GQDSSRCVACMVDSSLGVWVTLKGSAHVCL YHPDTFEQLAEVDVTPPVHRMLAGSDAIIR QHKAACLRITALLVCEELLWVGTSAGVVLT MPTSPGTVSCPRAPLSPTGLGQGHTGHVRF LAAVQLPDGFNLLCPTPPPPPDTGPEKLPS LEHRDSPWHRGPAPARPKMLVISGGDGYED FRLSSGGGSSSETVGRDDSTNHLLLWRV low complexity regions: XNU # Score cutoff = 21, Search from offsets 1 to 4 # both members of each repeat flagged # lambda = 0.347, K = 0.200, H = 0.664 >gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGS DAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALrrrrkvppsgsggsEFSNGEAGEAYRS LSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES KGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADIL SPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA APPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESlrtlmqgym qplkqpENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRI PRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEA HIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMS LYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKL SESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEF PHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPS PEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLRS PPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPELV PFdsdsddesspspsgtlqsqasrstisssfgneetpsskeataettsseeeqePGFLPL SGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVY QSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVT LGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGV WVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEEL LWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCptpp pppDTGPEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLssgggsssetvgrdd stnhlllWRV 1 - 153 MARRLPRTSA LKSSSSELLL TGPGAEEDPL PLIVQDQYVQ EARQVFEKIQ RMGAQQDDGS DAPPGSPDWA GDVTRGQRSQ EELSGPESSL TDEGIGADPE PPVAAFCGLG TTGMWRPLSS SSAQTNHHGP GTEDSLGGWA LVSPETPPTP GAL 154 - 167 rrrrkvp psgsggs 168 - 531 EFS NGEAGEAYRS LSDPIPQRHR AATSEEPTGF SVDSNLLGSL SPKTGLPATS AMDEGLT SGH SDWSVGSEES KGYQEVIQSI VQGPGTLGRV VDDRIAGKAP KKKSLSDPSR RGELAGP GFE GPGGEPIREV EPMLPPSSSE PILVEQRAEP EEPGATRSRA QSERALPEAL PPPATAH RNF HLDPKLADIL SPRLIRRGSK KRPARSSHQE LRRDEGSQDQ TGSLSRARPS SRHVRHA SVP ATFMPIVVPE PPTSVGPPVA VPEPIGFPTR AHPTLQAPSL EDVTKQYMLN LHSGEVP APV PVDMPCLPLA APPSAEAKPP EAARPADEPT PASKCCSKPQ VDMRKHVAMT LLDTEQS YVE S 532 - 546 lrtlmqgym qplkqp 547 - 1082 ENSV LCDPSLVDEI FDQIPELLEH HEQFLEQVRH CMQTWHAQQK VGALLVQSFS KDVLVN IYSA YIDNFLNAKD AVRVAKEARP AFLKFLEQSM RENKEKQALS DLMIKPVQRI PRYELL VKDL LKHTPEDHPD HPLLLEAQRN IKQVAERINK GVRSAEEAER HARVLQEIEA HIEGME DLQA PLRRFLRQEM VIEVKAIGGK KDRSLFLFTD LIVCTTLKRK SGSLRRSSMS LYTAAS VIDT ASKYKMLWKL PLEDADIIKG ASQATNRENI QKAISRLDED LTTLGQMSKL SESLGF PHQS LDDALRDLSA AMHRDLSEKQ ALCYALSFPP TKLELCATRP EGTDSYIFEF PHPDAR LGFE QAFDEAKRKL ASSKSCLDPE FLKAIPIMKT RSGMQFSCAA PTLNSCPEPS PEVWVC NSDG YVGQVCLLSL RAEPDVEACI AVCSARILCI GAVPGLQPRC HREPPPSLRS PPETAP EPAG PELDVEAAAD EEAATLAEPG PQPCLHISIA GSGLEMTPGL GEGDPRPELV PF 1083 - 1134 dsdsddes spspsgtlqs qasrstisss fgneetpssk eataettsse eeqe 1135 - 1436 PGFLPL SGSFGPGGPC GTSPMDGRAL RRSSHGSFTR GSLEDLLSVD PEAYQSSVWL GTED GCVHVY QSSDSIRDRR NSMKLQHAAS VTCILYLNNQ VFVSLANGEL VVYQREAGHF WDPQ NFKSVT LGTQGSPITK MVSVGGRLWC GCQNRVLVLS PDTLQLEHMF YVGQDSSRCV ACMV DSSLGV WVTLKGSAHV CLYHPDTFEQ LAEVDVTPPV HRMLAGSDAI IRQHKAACLR ITAL LVCEEL LWVGTSAGVV LTMPTSPGTV SCPRAPLSPT GLGQGHTGHV RFLAAVQLPD GFNL LC 1437 - 1443 ptpp ppp 1444 - 1485 DTGPEKL PSLEHRDSPW HRGPAPARPK MLVISGGDGY EDFRL 1486 - 1507 ssggg sssetvgrdd stnhlll 1508 - 1510 WRV low complexity regions: DUST >gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGS DAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSEFSNGEAGEAYRS LSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES KGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADIL SPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA APPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRI PRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEA HIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMS LYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKL SESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEF PHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPS PEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLRS PPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPELV PFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLPL SGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVY QSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVT LGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGV WVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEEL LWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPP PPPDTGPEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSSGGGSSSETVGRDD STNHLLLWRV ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ coiled coil prediction for gi|2224615|dbj|BAA20795.1| sequence: 1470 amino acids, 41 residue(s) in coiled coil state Coil 1 * 688* 729* RNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQA . | . | . | . | . | . 60 MARRLPRTSA LKSSSSELLL TGPGAEEDPL PLIVQDQYVQ EARQVFEKIQ RMGAQQDDGS ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~11 1111111111 11~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 120 DAPPGSPDWA GDVTRGQRSQ EELSGPESSL TDEGIGADPE PPVAAFCGLG TTGMWRPLSS ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 180 SSAQTNHHGP GTEDSLGGWA LVSPETPPTP GALRRRRKVP PSGSGGSEFS NGEAGEAYRS ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 240 LSDPIPQRHR AATSEEPTGF SVDSNLLGSL SPKTGLPATS AMDEGLTSGH SDWSVGSEES ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 300 KGYQEVIQSI VQGPGTLGRV VDDRIAGKAP KKKSLSDPSR RGELAGPGFE GPGGEPIREV ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 360 EPMLPPSSSE PILVEQRAEP EEPGATRSRA QSERALPEAL PPPATAHRNF HLDPKLADIL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 420 SPRLIRRGSK KRPARSSHQE LRRDEGSQDQ TGSLSRARPS SRHVRHASVP ATFMPIVVPE ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 480 PPTSVGPPVA VPEPIGFPTR AHPTLQAPSL EDVTKQYMLN LHSGEVPAPV PVDMPCLPLA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 540 APPSAEAKPP EAARPADEPT PASKCCSKPQ VDMRKHVAMT LLDTEQSYVE SLRTLMQGYM ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 600 QPLKQPENSV LCDPSLVDEI FDQIPELLEH HEQFLEQVRH CMQTWHAQQK VGALLVQSFS ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 660 KDVLVNIYSA YIDNFLNAKD AVRVAKEARP AFLKFLEQSM RENKEKQALS DLMIKPVQRI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~66666666 6666662221 ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 720 PRYELLVKDL LKHTPEDHPD HPLLLEAQRN IKQVAERINK GVRSAEEAER HARVLQEIEA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~33366 6666666666 6666699999 9999999999 * 21 M'95 -w border ---------- ---------- -----cdefg abcdefgabc defgafgabc defgabcdef * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~266666 6666666666 * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~11144466 6666666666 6666666666 5555555555 * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~99999999 9999999999 9999999999 9998888333 * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~37799999 9999999999 1145588888 8888888885 * 14 M'95 -w local . | . | . | . | . | . 780 HIEGMEDLQA PLRRFLRQEM VIEVKAIGGK KDRSLFLFTD LIVCTTLKRK SGSLRRSSMS 9999999553 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border gabcdefdef ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register 6666665221 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar 5555554221 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class 3333333333 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. 5555555553 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 840 LYTAASVIDT ASKYKMLWKL PLEDADIIKG ASQATNRENI QKAISRLDED LTTLGQMSKL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ 3334444444 4444444444 4444441~~~ * 21 M'95 -w border ---------- ---------- ---------- bcdefgabcd efgabcdefg abcdefg--- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ 3338888888 8888888888 888888611~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ 1112222222 2222222222 2222221~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~1166888 8888888888 8333~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 900 SESLGFPHQS LDDALRDLSA AMHRDLSEKQ ALCYALSFPP TKLELCATRP EGTDSYIFEF ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~22 2222222222 2211~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 960 PHPDARLGFE QAFDEAKRKL ASSKSCLDPE FLKAIPIMKT RSGMQFSCAA PTLNSCPEPS ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~366 6666666666 6652~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 1020 PEVWVCNSDG YVGQVCLLSL RAEPDVEACI AVCSARILCI GAVPGLQPRC HREPPPSLRS ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 1080 PPETAPEPAG PELDVEAAAD EEAATLAEPG PQPCLHISIA GSGLEMTPGL GEGDPRPELV ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~111111 11111111~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 1140 PFDSDSDDES SPSPSGTLQS QASRSTISSS FGNEETPSSK EATAETTSSE EEQEPGFLPL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 1200 SGSFGPGGPC GTSPMDGRAL RRSSHGSFTR GSLEDLLSVD PEAYQSSVWL GTEDGCVHVY ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 1260 QSSDSIRDRR NSMKLQHAAS VTCILYLNNQ VFVSLANGEL VVYQREAGHF WDPQNFKSVT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 1320 LGTQGSPITK MVSVGGRLWC GCQNRVLVLS PDTLQLEHMF YVGQDSSRCV ACMVDSSLGV ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 1380 WVTLKGSAHV CLYHPDTFEQ LAEVDVTPPV HRMLAGSDAI IRQHKAACLR ITALLVCEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 1440 LWVGTSAGVV LTMPTSPGTV SCPRAPLSPT GLGQGHTGHV RFLAAVQLPD GFNLLCPTPP ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | PPPDTGPEKL PSLEHRDSPW HRGPAPARPK ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ---------- ---------- ---------- ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ prediction of transmembrane regions with toppred2 *********************************** *TOPPREDM with eukaryotic function* *********************************** tem4.___inter___ is a single sequence Using hydrophobicity file: /bio_software/2D/toppredm/lib/Engelman-Steitz.scale Using cyt/ext file: /bio_software/2D/toppredm/lib/Cyt-Ext.prok Using sequence file: tem4.___inter___ (1 sequences) MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQ RMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPE PPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTP GALRRRRKVPPSGSGGSEFSNGEAGEAYRSLSDPIPQRHRAATSEEPTGF SVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSI VQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNF HLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPS SRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSL EDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAPPSAEAKPPEAARPADEPT PASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV LCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALS DLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINK GVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGK KDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKL PLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQS LDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEF PHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAA PTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCI GAVPGLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPG PQPCLHISIAGSGLEMTPGLGEGDPRPELVPFDSDSDDESSPSPSGTLQS QASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLPLSGSFGPGGPC GTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVY QSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHF WDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMF YVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPV HRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTV SCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDTGPEKL PSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSSGGGSSSETVGRDD STNHLLLWRV (p)rokaryotic or (e)ukaryotic: e Charge-pair energy: 0 Length of full window (odd number!): 21 Length of core window (odd number!): 11 Number of residues to add to each end of helix: 1 Critical length: 60 Upper cutoff for candidates: 1 Lower cutoff for candidates: 0.6 Total of 128 structures are to be tested Candidate membrane-spanning segments: Helix Begin End Score Certainity 1 99 119 0.874 Putative 2 407 427 0.848 Putative 3 465 485 0.617 Putative 4 987 1007 0.903 Putative 5 1052 1072 0.668 Putative 6 1135 1155 1.224 Certain 7 1217 1237 0.725 Putative 8 1308 1328 0.636 Putative 9 1380 1400 1.539 Certain Warning! Only printing 30 out of 128 structures ---------------------------------------------------------------------- Structure 1 Transmembrane segments included in this structure: Segment 1 2 3 4 5 6 7 8 9 Loop length 98 287 37 501 44 62 61 70 51 110 K+R profile + 2.00 3.00 + 5.00 + + + + + CYT-EXT prof -0.22 - - 0.28 - 0.43 -0.50 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 10.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -1.80 -> Orientation: N-in ---------------------------------------------------------------------- Structure 2 Transmembrane segments included in this structure: Segment 2 3 4 5 6 7 8 9 Loop length 406 37 501 44 62 61 70 51 110 K+R profile + + + + + 2.00 3.00 + 5.00 CYT-EXT prof 0.32 -0.50 0.19 1.18 0.57 - - 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -10.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 1.47 -> Orientation: N-out ---------------------------------------------------------------------- Structure 3 Transmembrane segments included in this structure: Segment 1 3 4 5 6 7 8 9 Loop length 98 345 501 44 62 61 70 51 110 K+R profile + + + + + + 3.00 + 5.00 CYT-EXT prof -0.22 -0.50 0.19 1.18 0.57 0.73 - 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -8.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 0.20 -> Orientation: N-out ---------------------------------------------------------------------- Structure 4 Transmembrane segments included in this structure: Segment 3 4 5 6 7 8 9 Loop length 464 501 44 62 61 70 51 110 K+R profile + 3.00 + 5.00 + + + + CYT-EXT prof 0.57 - 0.28 - -0.50 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 8.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0991 NEG: 61.0000 POS: 50.0000 -> Orientation: undecided CYT-EXT difference: -0.58 -> Orientation: N-in ---------------------------------------------------------------------- Structure 5 Transmembrane segments included in this structure: Segment 1 2 4 5 6 7 8 9 Loop length 98 287 559 44 62 61 70 51 110 K+R profile + + + + + + 3.00 + 5.00 CYT-EXT prof -0.22 -0.22 0.19 1.18 0.57 0.43 - 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -8.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 0.79 -> Orientation: N-out ---------------------------------------------------------------------- Structure 6 Transmembrane segments included in this structure: Segment 2 4 5 6 7 8 9 Loop length 406 559 44 62 61 70 51 110 K+R profile + 3.00 + 5.00 + + + + CYT-EXT prof 0.32 - 0.28 - -0.22 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 8.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: -1.12 -> Orientation: N-in ---------------------------------------------------------------------- Structure 7 Transmembrane segments included in this structure: Segment 1 4 5 6 7 8 9 Loop length 98 867 44 62 61 70 51 110 K+R profile + 3.00 + 5.00 + + + + CYT-EXT prof -0.22 - 0.28 - 0.21 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 8.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -2.08 -> Orientation: N-in ---------------------------------------------------------------------- Structure 8 Transmembrane segments included in this structure: Segment 4 5 6 7 8 9 Loop length 986 44 62 61 70 51 110 K+R profile + + + + 3.00 + 5.00 CYT-EXT prof 0.17 0.19 1.18 0.57 - 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -8.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -4.00 (NEG-POS)/(NEG+POS): 0.0837 NEG: 136.0000 POS: 115.0000 -> Orientation: N-out CYT-EXT difference: 1.83 -> Orientation: N-out ---------------------------------------------------------------------- Structure 9 Transmembrane segments included in this structure: Segment 1 2 3 6 7 8 9 Loop length 98 287 37 649 61 70 51 110 K+R profile + 2.00 + 5.00 + + + + CYT-EXT prof -0.22 - 0.28 - 0.43 -0.44 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 7.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -1.67 -> Orientation: N-in ---------------------------------------------------------------------- Structure 10 Transmembrane segments included in this structure: Segment 2 3 6 7 8 9 Loop length 406 37 649 61 70 51 110 K+R profile + + + + 2.00 + 5.00 CYT-EXT prof 0.32 -0.44 1.18 0.57 - 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -7.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 1.33 -> Orientation: N-out ---------------------------------------------------------------------- Structure 11 Transmembrane segments included in this structure: Segment 1 2 3 5 6 8 9 Loop length 98 287 37 566 62 152 51 110 K+R profile + 2.00 + 5.00 + + + + CYT-EXT prof -0.22 - 0.19 - 0.43 -0.57 1.05 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 7.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -1.51 -> Orientation: N-in ---------------------------------------------------------------------- Structure 12 Transmembrane segments included in this structure: Segment 2 3 5 6 8 9 Loop length 406 37 566 62 152 51 110 K+R profile + + + + 2.00 + 5.00 CYT-EXT prof 0.32 -0.57 1.05 0.57 - 0.19 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -7.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 1.17 -> Orientation: N-out ---------------------------------------------------------------------- Structure 13 Transmembrane segments included in this structure: Segment 1 2 3 4 6 8 9 Loop length 98 287 37 501 127 152 51 110 K+R profile + 2.00 + 5.00 + + + + CYT-EXT prof -0.22 - -0.06 - 0.43 -0.50 1.05 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 7.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -1.82 -> Orientation: N-in ---------------------------------------------------------------------- Structure 14 Transmembrane segments included in this structure: Segment 2 3 4 6 8 9 Loop length 406 37 501 127 152 51 110 K+R profile + + + + 2.00 + 5.00 CYT-EXT prof 0.32 -0.50 1.05 0.57 - -0.06 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -7.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 1.49 -> Orientation: N-out ---------------------------------------------------------------------- Structure 15 Transmembrane segments included in this structure: Segment 1 3 5 6 7 8 9 Loop length 98 345 566 62 61 70 51 110 K+R profile + + + 5.00 + + + + CYT-EXT prof -0.22 -0.57 0.28 - 0.73 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -3.18 -> Orientation: N-in ---------------------------------------------------------------------- Structure 16 Transmembrane segments included in this structure: Segment 3 5 6 7 8 9 Loop length 464 566 62 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof 0.57 0.19 1.18 0.57 -0.57 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0991 NEG: 61.0000 POS: 50.0000 -> Orientation: undecided CYT-EXT difference: 2.80 -> Orientation: N-out ---------------------------------------------------------------------- Structure 17 Transmembrane segments included in this structure: Segment 1 2 5 6 7 8 9 Loop length 98 287 624 62 61 70 51 110 K+R profile + + + 5.00 + + + + CYT-EXT prof -0.22 -0.31 0.28 - 0.43 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -2.61 -> Orientation: N-in ---------------------------------------------------------------------- Structure 18 Transmembrane segments included in this structure: Segment 2 5 6 7 8 9 Loop length 406 624 62 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof 0.32 0.19 1.18 0.57 -0.31 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 2.28 -> Orientation: N-out ---------------------------------------------------------------------- Structure 19 Transmembrane segments included in this structure: Segment 1 5 6 7 8 9 Loop length 98 932 62 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof -0.22 0.19 1.18 0.57 0.11 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 1.33 -> Orientation: N-out ---------------------------------------------------------------------- Structure 20 Transmembrane segments included in this structure: Segment 5 6 7 8 9 Loop length 1051 62 61 70 51 110 K+R profile + + 5.00 + + + CYT-EXT prof 0.09 0.28 - 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -1.00 (NEG-POS)/(NEG+POS): 0.1019 NEG: 146.0000 POS: 119.0000 -> Orientation: N-out CYT-EXT difference: -1.57 -> Orientation: N-in ---------------------------------------------------------------------- Structure 21 Transmembrane segments included in this structure: Segment 1 3 4 6 7 8 9 Loop length 98 345 501 127 61 70 51 110 K+R profile + + + 5.00 + + + + CYT-EXT prof -0.22 -0.50 0.28 - 0.73 -0.06 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -2.86 -> Orientation: N-in ---------------------------------------------------------------------- Structure 22 Transmembrane segments included in this structure: Segment 3 4 6 7 8 9 Loop length 464 501 127 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof 0.57 -0.06 1.18 0.57 -0.50 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0991 NEG: 61.0000 POS: 50.0000 -> Orientation: undecided CYT-EXT difference: 2.48 -> Orientation: N-out ---------------------------------------------------------------------- Structure 23 Transmembrane segments included in this structure: Segment 1 2 4 6 7 8 9 Loop length 98 287 559 127 61 70 51 110 K+R profile + + + 5.00 + + + + CYT-EXT prof -0.22 -0.22 0.28 - 0.43 -0.06 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.01 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -2.28 -> Orientation: N-in ---------------------------------------------------------------------- Structure 24 Transmembrane segments included in this structure: Segment 2 4 6 7 8 9 Loop length 406 559 127 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof 0.32 -0.06 1.18 0.57 -0.22 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.01 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 1.94 -> Orientation: N-out ---------------------------------------------------------------------- Structure 25 Transmembrane segments included in this structure: Segment 1 4 6 7 8 9 Loop length 98 867 127 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof -0.22 -0.06 1.18 0.57 0.21 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.01 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 0.98 -> Orientation: N-out ---------------------------------------------------------------------- Structure 26 Transmembrane segments included in this structure: Segment 4 6 7 8 9 Loop length 986 127 61 70 51 110 K+R profile + + 5.00 + + + CYT-EXT prof 0.17 0.28 - -0.06 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.02 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -4.00 (NEG-POS)/(NEG+POS): 0.0837 NEG: 136.0000 POS: 115.0000 -> Orientation: N-out CYT-EXT difference: -1.24 -> Orientation: N-in ---------------------------------------------------------------------- Structure 27 Transmembrane segments included in this structure: Segment 1 3 6 7 8 9 Loop length 98 345 649 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof -0.22 -0.44 1.18 0.57 0.73 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 0.07 -> Orientation: N-out ---------------------------------------------------------------------- Structure 28 Transmembrane segments included in this structure: Segment 3 6 7 8 9 Loop length 464 649 61 70 51 110 K+R profile + + 5.00 + + + CYT-EXT prof 0.57 0.28 - -0.44 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0991 NEG: 61.0000 POS: 50.0000 -> Orientation: undecided CYT-EXT difference: -0.45 -> Orientation: N-in ---------------------------------------------------------------------- Structure 29 Transmembrane segments included in this structure: Segment 1 2 6 7 8 9 Loop length 98 287 707 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof -0.22 -0.23 1.18 0.57 0.43 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.01 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 0.58 -> Orientation: N-out ---------------------------------------------------------------------- Structure 30 Transmembrane segments included in this structure: Segment 2 6 7 8 9 Loop length 406 707 61 70 51 110 K+R profile + + 5.00 + + + CYT-EXT prof 0.32 0.28 - -0.23 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.02 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: -0.91 -> Orientation: N-in ---------------------------------------------------------------------- "tem4" 1510 99 119 #f 0.873958 407 427 #f 0.847917 465 485 #f 0.616667 987 1007 #f 0.903125 1052 1072 #f 0.667708 1135 1155 #t 1.22396 1217 1237 #f 0.725 1308 1328 #f 0.636458 1380 1400 #t 1.53854 ************************************ *TOPPREDM with prokaryotic function* ************************************ tem4.___inter___ is a single sequence Using hydrophobicity file: /bio_software/2D/toppredm/lib/Engelman-Steitz.scale Using cyt/ext file: /bio_software/2D/toppredm/lib/Cyt-Ext.prok Using sequence file: tem4.___inter___ (1 sequences) MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQ RMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPE PPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTP GALRRRRKVPPSGSGGSEFSNGEAGEAYRSLSDPIPQRHRAATSEEPTGF SVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSI VQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNF HLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPS SRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSL EDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAPPSAEAKPPEAARPADEPT PASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV LCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALS DLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINK GVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGK KDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKL PLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQS LDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEF PHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAA PTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCI GAVPGLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPG PQPCLHISIAGSGLEMTPGLGEGDPRPELVPFDSDSDDESSPSPSGTLQS QASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLPLSGSFGPGGPC GTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVY QSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHF WDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMF YVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPV HRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTV SCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDTGPEKL PSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSSGGGSSSETVGRDD STNHLLLWRV (p)rokaryotic or (e)ukaryotic: p Charge-pair energy: 0 Length of full window (odd number!): 21 Length of core window (odd number!): 11 Number of residues to add to each end of helix: 1 Critical length: 60 Upper cutoff for candidates: 1 Lower cutoff for candidates: 0.6 Total of 128 structures are to be tested Candidate membrane-spanning segments: Helix Begin End Score Certainity 1 99 119 0.874 Putative 2 407 427 0.848 Putative 3 465 485 0.617 Putative 4 987 1007 0.903 Putative 5 1052 1072 0.668 Putative 6 1135 1155 1.224 Certain 7 1217 1237 0.725 Putative 8 1308 1328 0.636 Putative 9 1380 1400 1.539 Certain Warning! Only printing 30 out of 128 structures ---------------------------------------------------------------------- Structure 1 Transmembrane segments included in this structure: Segment 1 2 3 4 5 6 7 8 9 Loop length 98 287 37 501 44 62 61 70 51 110 K+R profile + 2.00 3.00 + 5.00 + + + + + CYT-EXT prof -0.22 - - 0.28 - 0.43 -0.50 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 10.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -1.80 -> Orientation: N-in ---------------------------------------------------------------------- Structure 2 Transmembrane segments included in this structure: Segment 2 3 4 5 6 7 8 9 Loop length 406 37 501 44 62 61 70 51 110 K+R profile + + + + + 2.00 3.00 + 5.00 CYT-EXT prof 0.32 -0.50 0.19 1.18 0.57 - - 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -10.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 1.47 -> Orientation: N-out ---------------------------------------------------------------------- Structure 3 Transmembrane segments included in this structure: Segment 1 3 4 5 6 7 8 9 Loop length 98 345 501 44 62 61 70 51 110 K+R profile + + + + + + 3.00 + 5.00 CYT-EXT prof -0.22 -0.50 0.19 1.18 0.57 0.73 - 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -8.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 0.20 -> Orientation: N-out ---------------------------------------------------------------------- Structure 4 Transmembrane segments included in this structure: Segment 3 4 5 6 7 8 9 Loop length 464 501 44 62 61 70 51 110 K+R profile + 3.00 + 5.00 + + + + CYT-EXT prof 0.57 - 0.28 - -0.50 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 8.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0991 NEG: 61.0000 POS: 50.0000 -> Orientation: undecided CYT-EXT difference: -0.58 -> Orientation: N-in ---------------------------------------------------------------------- Structure 5 Transmembrane segments included in this structure: Segment 1 2 4 5 6 7 8 9 Loop length 98 287 559 44 62 61 70 51 110 K+R profile + + + + + + 3.00 + 5.00 CYT-EXT prof -0.22 -0.22 0.19 1.18 0.57 0.43 - 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -8.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 0.79 -> Orientation: N-out ---------------------------------------------------------------------- Structure 6 Transmembrane segments included in this structure: Segment 2 4 5 6 7 8 9 Loop length 406 559 44 62 61 70 51 110 K+R profile + 3.00 + 5.00 + + + + CYT-EXT prof 0.32 - 0.28 - -0.22 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 8.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: -1.12 -> Orientation: N-in ---------------------------------------------------------------------- Structure 7 Transmembrane segments included in this structure: Segment 1 4 5 6 7 8 9 Loop length 98 867 44 62 61 70 51 110 K+R profile + 3.00 + 5.00 + + + + CYT-EXT prof -0.22 - 0.28 - 0.21 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 8.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -2.08 -> Orientation: N-in ---------------------------------------------------------------------- Structure 8 Transmembrane segments included in this structure: Segment 4 5 6 7 8 9 Loop length 986 44 62 61 70 51 110 K+R profile + + + + 3.00 + 5.00 CYT-EXT prof 0.17 0.19 1.18 0.57 - 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -8.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -4.00 (NEG-POS)/(NEG+POS): 0.0837 NEG: 136.0000 POS: 115.0000 -> Orientation: N-out CYT-EXT difference: 1.83 -> Orientation: N-out ---------------------------------------------------------------------- Structure 9 Transmembrane segments included in this structure: Segment 1 2 3 6 7 8 9 Loop length 98 287 37 649 61 70 51 110 K+R profile + 2.00 + 5.00 + + + + CYT-EXT prof -0.22 - 0.28 - 0.43 -0.44 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 7.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -1.67 -> Orientation: N-in ---------------------------------------------------------------------- Structure 10 Transmembrane segments included in this structure: Segment 2 3 6 7 8 9 Loop length 406 37 649 61 70 51 110 K+R profile + + + + 2.00 + 5.00 CYT-EXT prof 0.32 -0.44 1.18 0.57 - 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -7.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 1.33 -> Orientation: N-out ---------------------------------------------------------------------- Structure 11 Transmembrane segments included in this structure: Segment 1 2 3 5 6 8 9 Loop length 98 287 37 566 62 152 51 110 K+R profile + 2.00 + 5.00 + + + + CYT-EXT prof -0.22 - 0.19 - 0.43 -0.57 1.05 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 7.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -1.51 -> Orientation: N-in ---------------------------------------------------------------------- Structure 12 Transmembrane segments included in this structure: Segment 2 3 5 6 8 9 Loop length 406 37 566 62 152 51 110 K+R profile + + + + 2.00 + 5.00 CYT-EXT prof 0.32 -0.57 1.05 0.57 - 0.19 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -7.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 1.17 -> Orientation: N-out ---------------------------------------------------------------------- Structure 13 Transmembrane segments included in this structure: Segment 1 2 3 4 6 8 9 Loop length 98 287 37 501 127 152 51 110 K+R profile + 2.00 + 5.00 + + + + CYT-EXT prof -0.22 - -0.06 - 0.43 -0.50 1.05 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 7.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -1.82 -> Orientation: N-in ---------------------------------------------------------------------- Structure 14 Transmembrane segments included in this structure: Segment 2 3 4 6 8 9 Loop length 406 37 501 127 152 51 110 K+R profile + + + + 2.00 + 5.00 CYT-EXT prof 0.32 -0.50 1.05 0.57 - -0.06 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -7.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 1.49 -> Orientation: N-out ---------------------------------------------------------------------- Structure 15 Transmembrane segments included in this structure: Segment 1 3 5 6 7 8 9 Loop length 98 345 566 62 61 70 51 110 K+R profile + + + 5.00 + + + + CYT-EXT prof -0.22 -0.57 0.28 - 0.73 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -3.18 -> Orientation: N-in ---------------------------------------------------------------------- Structure 16 Transmembrane segments included in this structure: Segment 3 5 6 7 8 9 Loop length 464 566 62 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof 0.57 0.19 1.18 0.57 -0.57 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0991 NEG: 61.0000 POS: 50.0000 -> Orientation: undecided CYT-EXT difference: 2.80 -> Orientation: N-out ---------------------------------------------------------------------- Structure 17 Transmembrane segments included in this structure: Segment 1 2 5 6 7 8 9 Loop length 98 287 624 62 61 70 51 110 K+R profile + + + 5.00 + + + + CYT-EXT prof -0.22 -0.31 0.28 - 0.43 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -2.61 -> Orientation: N-in ---------------------------------------------------------------------- Structure 18 Transmembrane segments included in this structure: Segment 2 5 6 7 8 9 Loop length 406 624 62 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof 0.32 0.19 1.18 0.57 -0.31 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 2.28 -> Orientation: N-out ---------------------------------------------------------------------- Structure 19 Transmembrane segments included in this structure: Segment 1 5 6 7 8 9 Loop length 98 932 62 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof -0.22 0.19 1.18 0.57 0.11 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 1.33 -> Orientation: N-out ---------------------------------------------------------------------- Structure 20 Transmembrane segments included in this structure: Segment 5 6 7 8 9 Loop length 1051 62 61 70 51 110 K+R profile + + 5.00 + + + CYT-EXT prof 0.09 0.28 - 0.19 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -1.00 (NEG-POS)/(NEG+POS): 0.1019 NEG: 146.0000 POS: 119.0000 -> Orientation: N-out CYT-EXT difference: -1.57 -> Orientation: N-in ---------------------------------------------------------------------- Structure 21 Transmembrane segments included in this structure: Segment 1 3 4 6 7 8 9 Loop length 98 345 501 127 61 70 51 110 K+R profile + + + 5.00 + + + + CYT-EXT prof -0.22 -0.50 0.28 - 0.73 -0.06 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -2.86 -> Orientation: N-in ---------------------------------------------------------------------- Structure 22 Transmembrane segments included in this structure: Segment 3 4 6 7 8 9 Loop length 464 501 127 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof 0.57 -0.06 1.18 0.57 -0.50 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0991 NEG: 61.0000 POS: 50.0000 -> Orientation: undecided CYT-EXT difference: 2.48 -> Orientation: N-out ---------------------------------------------------------------------- Structure 23 Transmembrane segments included in this structure: Segment 1 2 4 6 7 8 9 Loop length 98 287 559 127 61 70 51 110 K+R profile + + + 5.00 + + + + CYT-EXT prof -0.22 -0.22 0.28 - 0.43 -0.06 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.01 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: -2.28 -> Orientation: N-in ---------------------------------------------------------------------- Structure 24 Transmembrane segments included in this structure: Segment 2 4 6 7 8 9 Loop length 406 559 127 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof 0.32 -0.06 1.18 0.57 -0.22 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.01 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: 1.94 -> Orientation: N-out ---------------------------------------------------------------------- Structure 25 Transmembrane segments included in this structure: Segment 1 4 6 7 8 9 Loop length 98 867 127 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof -0.22 -0.06 1.18 0.57 0.21 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.01 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 0.98 -> Orientation: N-out ---------------------------------------------------------------------- Structure 26 Transmembrane segments included in this structure: Segment 4 6 7 8 9 Loop length 986 127 61 70 51 110 K+R profile + + 5.00 + + + CYT-EXT prof 0.17 0.28 - -0.06 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.02 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): -4.00 (NEG-POS)/(NEG+POS): 0.0837 NEG: 136.0000 POS: 115.0000 -> Orientation: N-out CYT-EXT difference: -1.24 -> Orientation: N-in ---------------------------------------------------------------------- Structure 27 Transmembrane segments included in this structure: Segment 1 3 6 7 8 9 Loop length 98 345 649 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof -0.22 -0.44 1.18 0.57 0.73 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 0.07 -> Orientation: N-out ---------------------------------------------------------------------- Structure 28 Transmembrane segments included in this structure: Segment 3 6 7 8 9 Loop length 464 649 61 70 51 110 K+R profile + + 5.00 + + + CYT-EXT prof 0.57 0.28 - -0.44 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.00 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0991 NEG: 61.0000 POS: 50.0000 -> Orientation: undecided CYT-EXT difference: -0.45 -> Orientation: N-in ---------------------------------------------------------------------- Structure 29 Transmembrane segments included in this structure: Segment 1 2 6 7 8 9 Loop length 98 287 707 61 70 51 110 K+R profile + + + + + + 5.00 CYT-EXT prof -0.22 -0.23 1.18 0.57 0.43 0.28 - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -5.00 Tm probability: 0.01 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): -6.00 (NEG-POS)/(NEG+POS): 0.3571 NEG: 19.0000 POS: 9.0000 -> Orientation: N-out CYT-EXT difference: 0.58 -> Orientation: N-out ---------------------------------------------------------------------- Structure 30 Transmembrane segments included in this structure: Segment 2 6 7 8 9 Loop length 406 707 61 70 51 110 K+R profile + + 5.00 + + + CYT-EXT prof 0.32 0.28 - -0.23 1.18 0.57 For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 5.00 Tm probability: 0.02 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 4.00 (NEG-POS)/(NEG+POS): 0.0769 NEG: 56.0000 POS: 48.0000 -> Orientation: N-in CYT-EXT difference: -0.91 -> Orientation: N-in ---------------------------------------------------------------------- "tem4" 1510 99 119 #f 0.873958 407 427 #f 0.847917 465 485 #f 0.616667 987 1007 #f 0.903125 1052 1072 #f 0.667708 1135 1155 #t 1.22396 1217 1237 #f 0.725 1308 1328 #f 0.636458 1380 1400 #t 1.53854 ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ SAPS. Version of April 11, 1996. Date run: Wed Oct 11 20:38:41 2000 File: /people/maria/tem4.___saps___ ID gi|2224615|dbj|BAA20795.1| DE KIAA0337 [Homo sapiens] number of residues: 1510; molecular weight: 163.6 kdal 1 MARRLPRTSA LKSSSSELLL TGPGAEEDPL PLIVQDQYVQ EARQVFEKIQ RMGAQQDDGS 61 DAPPGSPDWA GDVTRGQRSQ EELSGPESSL TDEGIGADPE PPVAAFCGLG TTGMWRPLSS 121 SSAQTNHHGP GTEDSLGGWA LVSPETPPTP GALRRRRKVP PSGSGGSEFS NGEAGEAYRS 181 LSDPIPQRHR AATSEEPTGF SVDSNLLGSL SPKTGLPATS AMDEGLTSGH SDWSVGSEES 241 KGYQEVIQSI VQGPGTLGRV VDDRIAGKAP KKKSLSDPSR RGELAGPGFE GPGGEPIREV 301 EPMLPPSSSE PILVEQRAEP EEPGATRSRA QSERALPEAL PPPATAHRNF HLDPKLADIL 361 SPRLIRRGSK KRPARSSHQE LRRDEGSQDQ TGSLSRARPS SRHVRHASVP ATFMPIVVPE 421 PPTSVGPPVA VPEPIGFPTR AHPTLQAPSL EDVTKQYMLN LHSGEVPAPV PVDMPCLPLA 481 APPSAEAKPP EAARPADEPT PASKCCSKPQ VDMRKHVAMT LLDTEQSYVE SLRTLMQGYM 541 QPLKQPENSV LCDPSLVDEI FDQIPELLEH HEQFLEQVRH CMQTWHAQQK VGALLVQSFS 601 KDVLVNIYSA YIDNFLNAKD AVRVAKEARP AFLKFLEQSM RENKEKQALS DLMIKPVQRI 661 PRYELLVKDL LKHTPEDHPD HPLLLEAQRN IKQVAERINK GVRSAEEAER HARVLQEIEA 721 HIEGMEDLQA PLRRFLRQEM VIEVKAIGGK KDRSLFLFTD LIVCTTLKRK SGSLRRSSMS 781 LYTAASVIDT ASKYKMLWKL PLEDADIIKG ASQATNRENI QKAISRLDED LTTLGQMSKL 841 SESLGFPHQS LDDALRDLSA AMHRDLSEKQ ALCYALSFPP TKLELCATRP EGTDSYIFEF 901 PHPDARLGFE QAFDEAKRKL ASSKSCLDPE FLKAIPIMKT RSGMQFSCAA PTLNSCPEPS 961 PEVWVCNSDG YVGQVCLLSL RAEPDVEACI AVCSARILCI GAVPGLQPRC HREPPPSLRS 1021 PPETAPEPAG PELDVEAAAD EEAATLAEPG PQPCLHISIA GSGLEMTPGL GEGDPRPELV 1081 PFDSDSDDES SPSPSGTLQS QASRSTISSS FGNEETPSSK EATAETTSSE EEQEPGFLPL 1141 SGSFGPGGPC GTSPMDGRAL RRSSHGSFTR GSLEDLLSVD PEAYQSSVWL GTEDGCVHVY 1201 QSSDSIRDRR NSMKLQHAAS VTCILYLNNQ VFVSLANGEL VVYQREAGHF WDPQNFKSVT 1261 LGTQGSPITK MVSVGGRLWC GCQNRVLVLS PDTLQLEHMF YVGQDSSRCV ACMVDSSLGV 1321 WVTLKGSAHV CLYHPDTFEQ LAEVDVTPPV HRMLAGSDAI IRQHKAACLR ITALLVCEEL 1381 LWVGTSAGVV LTMPTSPGTV SCPRAPLSPT GLGQGHTGHV RFLAAVQLPD GFNLLCPTPP 1441 PPPDTGPEKL PSLEHRDSPW HRGPAPARPK MLVISGGDGY EDFRLSSGGG SSSETVGRDD 1501 STNHLLLWRV -------------------------------------------------------------------------------- COMPOSITIONAL ANALYSIS (extremes relative to: swp23s) A :121( 8.0%); C : 31( 2.1%); D : 81( 5.4%); E :116( 7.7%); F : 38( 2.5%) G :112( 7.4%); H : 40( 2.6%); I : 47( 3.1%); K : 56( 3.7%); L :150( 9.9%) M : 32( 2.1%); N- : 25( 1.7%); P+ :144( 9.5%); Q : 68( 4.5%); R : 95( 6.3%) S :156(10.3%); T : 74( 4.9%); V : 89( 5.9%); W : 14( 0.9%); Y : 21( 1.4%) KR : 151 ( 10.0%); ED : 197 ( 13.0%); AGP : 377 ( 25.0%); KRED : 348 ( 23.0%); KR-ED : -46 ( -3.0%); FIKMNY- : 219 ( 14.5%); LVIFM : 356 ( 23.6%); ST : 230 ( 15.2%). -------------------------------------------------------------------------------- CHARGE DISTRIBUTIONAL ANALYSIS 1 00++00+000 0+0000-000 00000---00 00000-0000 -0+000-+00 +00000--00 61 -000000-00 0-00+00+00 --0000-000 0--0000-0- 0000000000 00000+0000 121 0000000000 00--000000 0000-00000 000+++++00 0000000-00 00-00-00+0 181 00-0000+0+ 0000--0000 00-0000000 00+0000000 00--000000 0-00000--0 241 +000-00000 00000000+0 0--+000+00 +++000-00+ +0-000000- 0000-00+-0 301 -00000000- 0000-0+0-0 --0000+0+0 00-+000-00 0000000+00 00-0+00-00 361 00+00++00+ ++00+0000- 0++--000-0 00000+0+00 0+00+00000 000000000- 421 0000000000 00-000000+ 0000000000 --00+00000 0000-00000 00-0000000 481 00000-0+00 -00+00--00 000+000+00 0-0++00000 00-0-0000- 00+0000000 541 000+00-000 00-0000--0 0-000-00-0 0-000-00+0 000000000+ 0000000000 601 +-00000000 00-00000+- 00+00+-0+0 000+00-000 +-0+-+0000 -000+000+0 661 0+0-000+-0 0+000--00- 00000-00+0 0+000-+00+ 00+00--0-+ 00+000-0-0 721 00-00--000 00++00+0-0 00-0+0000+ +-+000000- 0000000+++ 0000++0000 781 00000000-0 00+0+000+0 00--0-00+0 000000+-00 0+000+0--- 00000000+0 841 0-00000000 0--00+-000 000+-00-+0 0000000000 0+0-0000+0 -00-0000-0 901 000-0+000- 000--0+++0 000+000-0- 00+00000+0 +000000000 0000000-00 961 0-000000-0 0000000000 +0-0-0-000 00000+0000 00000000+0 0+-00000+0 1021 00-000-000 0-0-0-000- --00000-00 0000000000 0000-00000 0-0-0+0-00 1081 00-0-0---0 0000000000 000+000000 000--0000+ -000-0000- --0-000000 1141 0000000000 00000-0+00 ++0000000+ 000--0000- 0-00000000 00--000000 1201 000-00+-++ 000+000000 0000000000 00000000-0 0000+-0000 0-0000+000 1261 000000000+ 000000+000 0000+00000 0-0000-000 0000-00+00 0000-00000 1321 0000+00000 00000-00-0 00-0-00000 0+00000-00 0+00+0000+ 0000000--0 1381 0000000000 0000000000 000+000000 0000000000 +00000000- 0000000000 1441 000-000-+0 000-0+-000 0+00000+0+ 0000000-00 --0+000000 000-000+-- 1501 00000000+0 A. CHARGE CLUSTERS. Positive charge clusters (cmin = 11/30 or 14/45 or 17/60): none Negative charge clusters (cmin = 13/30 or 17/45 or 20/60): none Mixed charge clusters (cmin = 18/30 or 24/45 or 30/60): none B. HIGH SCORING (UN)CHARGED SEGMENTS. There are no high scoring positive charge segments. There are no high scoring negative charge segments. There are no high scoring mixed charge segments. There are no high scoring uncharged segments. C. CHARGE RUNS AND PATTERNS. pattern (+)| (-)| (*)| (0)| (+0)| (-0)| (*0)|(+00)|(-00)|(*00)| (H.)|(H..)| lmin0 5 | 6 | 8 | 40 | 10 | 11 | 14 | 12 | 13 | 17 | 7 | 10 | lmin1 7 | 7 | 10 | 48 | 12 | 13 | 17 | 15 | 16 | 20 | 9 | 12 | lmin2 8 | 9 | 11 | 53 | 14 | 15 | 19 | 17 | 18 | 23 | 10 | 13 | (Significance level: 0.010000; Minimal displayed length: 6) There are no charge runs or patterns exceeding the given minimal lengths. Run count statistics: + runs >= 3: 5, at 154; 271; 370; 768; 917; - runs >= 4: 0 * runs >= 5: 1, at 154; 0 runs >= 27: 0 -------------------------------------------------------------------------------- DISTRIBUTION OF OTHER AMINO ACID TYPES 1. HIGH SCORING SEGMENTS. There are no high scoring hydrophobic segments. There are no high scoring transmembrane segments. 2. SPACINGS OF C. H2N-106-C-368-C-28-C-C-45-C-28-C-182-C-108-C-12-C-39-C-21-C-7-C-9-C-9-C-12-C-3-C-5-C-10-C-43-C-95-C-45-C-26-C-56-C-1-C-26-C-2-C-18-C-36-C-8-C-24-C-33-C-74-COOH 2*. SPACINGS OF C and H. (additional deluxe function for ALEX) H2N-106-C-19-H-H-60-H-40-H-116-H-3-H-26-H-24-H-2-H-35-H-19-H-13-C-28-C-C-9-H-35-C-17-H-H-8-H-C-4-H-86-H-4-H-2-H-29-H-9-H-42-C-83-H-14-H-9-C-12-C-15-H-23-C-21-C-7-C-9-C-9-C-12-C-3-C-5-C-10-C-H-42-C-1-H-93-C-14-H-30-C-1-H-18-H-5-C-25-H-30-C-1-C-15-H-10-C-2-C-16-H-1-C-2-H-16-H-12-H-3-C-8-C-24-C-13-H-2-H-16-C-18-H-5-H-42-H-6-COOH -------------------------------------------------------------------------------- REPETITIVE STRUCTURES. A. SEPARATED, TANDEM, AND PERIODIC REPEATS: amino acid alphabet. Repeat core block length: 5 Aligned matching blocks: [ 180- 184] SLSDP [ 274- 278] SLSDP ______________________________ [ 645- 649] EKQAL [ 868- 872] EKQAL ______________________________ [ 774- 778] LRRSS [1160-1164] LRRSS B. SEPARATED AND TANDEM REPEATS: 11-letter reduced alphabet. (i= LVIF; += KR; -= ED; s= AG; o= ST; n= NQ; a= YW; p= P; h= H; m= M; c= C) Repeat core block length: 9 -------------------------------------------------------------------------------- MULTIPLETS. A. AMINO ACID ALPHABET. 1. Total number of amino acid multiplets: 111 (Expected range: 65--122) 2. Histogram of spacings between consecutive amino acid multiplets: (1-5) 40 (6-10) 26 (11-20) 24 (>=21) 22 3. Clusters of amino acid multiplets (cmin = 12/30 or 16/45 or 19/60): none 4. Long amino acid multiplets (>= 5; Letter/Length/Position): P/5/1439 B. CHARGE ALPHABET. 1. Total number of charge multiplets: 45 (Expected range: 18-- 54) 15 +plets (f+: 10.0%), 30 -plets (f-: 13.0%) Total number of charge altplets: 25 (Critical number: 59) 2. Histogram of spacings between consecutive charge multiplets: (1-5) 5 (6-10) 5 (11-20) 12 (>=21) 24 3. Long charge multiplets (>= 5; Letter/Length/Position): +/5/154 -------------------------------------------------------------------------------- PERIODICITY ANALYSIS. A. AMINO ACID ALPHABET (core: 4; !-core: 5) Location Period Element Copies Core Errors 13- 16 1 S 4 4 0 53- 76 6 G..... 4 4 0 119- 122 1 S 4 4 0 154- 157 1 R 4 4 0 228- 242 3 S.. 5 5 ! 0 278- 313 9 P....E... 4 4 /0/././././1/./././ 352- 367 4 L... 4 4 0 483- 506 6 P..... 4 4 0 676- 715 10 E......... 4 4 0 1016-1035 5 P.... 4 4 0 1090-1114 5 S.... 5 5 ! 0 1142-1153 3 G.. 4 4 0 1439-1443 1 P 5 5 ! 0 1439-1454 4 P... 4 4 0 B. CHARGE ALPHABET ({+= KR; -= ED; 0}; core: 5; !-core: 7) and HYDROPHOBICITY ALPHABET ({*= KRED; i= LVIF; 0}; core: 6; !-core: 9) Location Period Element Copies Core Errors 154- 158 1 + 5 5 0 522- 570 7 i.0..00 7 7 /0/./2/././2/2/ 703- 762 10 *...*..... 6 6 /0/./././2/./././././ 1179-1250 9 i...00... 8 8 /0/./././2/1/./././ 1278-1325 8 i0..00.0 6 6 /0/1/././2/2/./2/ 1314-1361 8 i000.0.. 6 6 /0/2/2/2/./1/././ -------------------------------------------------------------------------------- SPACING ANALYSIS. Location (Quartile) Spacing Rank P-value Interpretation 107- 476 (1.) C( 369)C 1 of 32 0.0049 large maximal spacing 787- 963 (3.) V( 176)V 1 of 90 0.0010 large 1. maximal spacing 1080-1179 (3.) V( 99)V 2 of 90 0.0094 large 2. maximal spacing ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with Pfam (from /data/patterns/pfam) hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/pfam/Pfam Sequence file: tem4 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- RhoGEF RhoGEF domain 155.8 7.5e-43 1 SH2 Src homology domain 2 4.3 3.3 1 NGF Nerve growth factor family 2.1 19 1 Gastrin Gastrin/cholecystokinin family 1.1 56 1 COLFI Fibrillar collagen C-terminal domain -1.7 78 1 STAT STAT protein -2.8 79 1 SpoA Surface presentation of antigens (SPOA) pr -25.4 87 1 DB DB module -49.0 64 1 DUF61 Protein of unknown function DUF61 -64.4 52 1 Collagen Collagen triple helix repeat (20 copies) -86.3 83 1 Keratin_B2 Keratin, high sulfur B2 protein -91.0 28 1 Translin Translin family -94.7 73 1 DUF47 Protein of unknown function DUF47 -106.1 62 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- NGF 1/1 276 285 .. 1 10 [. 2.1 19 Collagen 1/1 253 311 .. 1 60 [] -86.3 83 COLFI 1/1 359 376 .. 1 15 [. -1.7 78 STAT 1/1 452 461 .. 616 625 .] -2.8 79 SH2 1/1 561 571 .. 69 79 .] 4.3 3.3 RhoGEF 1/1 517 700 .. 1 207 [] 155.8 7.5e-43 DUF47 1/1 558 706 .. 1 224 [] -106.1 62 SpoA 1/1 645 711 .. 1 80 [] -25.4 87 Gastrin 1/1 703 712 .. 117 126 .] 1.1 56 DUF61 1/1 686 794 .. 1 140 [] -64.4 52 Translin 1/1 684 839 .. 1 224 [] -94.7 73 DB 1/1 939 1012 .. 1 124 [] -49.0 64 Keratin_B2 1/1 918 1029 .. 1 177 [] -91.0 28 Alignments of top-scoring domains: NGF: domain 1 of 1, from 276 to 285: score 2.1, E = 19 *->epvsrRGElS<-* +++srRGEl+ gi|2224615 276 SDPSRRGELA 285 Collagen: domain 1 of 1, from 253 to 311: score -86.3, E = 83 *->GppGppGppGppGppGppGppGpaGapGppGppGepGpPGppGppGp pG G+ + +G++ + p +G pG+ Gp G+p gi|2224615 253 -GPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIR 298 pGppGapGapGpp<-* +p p + +p gi|2224615 299 EVEPMLPPSSSEP 311 COLFI: domain 1 of 1, from 359 to 376: score -1.7, E = 78 *->lksP....eGksrknPARt<-* ++sP+ + G s+k PAR+ gi|2224615 359 ILSPrlirRG-SKKRPARS 376 STAT: domain 1 of 1, from 452 to 461: score -2.8, E = 79 *->DLiKkHllpl<-* D++K ++l l gi|2224615 452 DVTKQYMLNL 461 SH2: domain 1 of 1, from 561 to 571: score 4.3, E = 3.3 *->FssLpeLvehY<-* F+ +peL eh+ gi|2224615 561 FDQIPELLEHH 571 RhoGEF: domain 1 of 1, from 517 to 700: score 155.8, E = 7.5e-43 *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF v+ ll TE Yv++L++l ++ym+pL++++ s + +p ++ iF gi|2224615 517 VAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIF 561 sNiediyefhreFLkssLearisssqfedlDekkiepsaprlGdlFlkl. i++++e h +FL +++++ ++ +G+l+ ++ gi|2224615 562 DQIPELLEHHEQFLE-QVRHCMQTW-----------HAQQKVGALLVQSf 599 .kepflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgA +k+ ++Y +Y++n+ +A++ ++ ++++p+F +fl++ + + n++ gi|2224615 600 sKDVLVNIYSAYIDNFLNAKDAVRV--AKEARPAFLKFLEQSMRE-NKE- 645 kddavkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkkal k L++L++kPvqRi+rY+LL+k+LLkhtpe d+pd+++L +a+ gi|2224615 646 -----KQALSDLMIKPVQRIPRYELLVKDLLKHTPE--DHPDHPLLLEAQ 688 dllqdlaksiNe<-* ++++ +a++iN+ gi|2224615 689 RNIKQVAERINK 700 DUF47: domain 1 of 1, from 558 to 706: score -106.1, E = 62 *->klflFekspfkplieHlekvvetvlkleelfealirGdyervEellk + f+ + e+le +++ ++ + ++++ + + ++ + gi|2224615 558 ------DEIFDQIPELLEHHEQFLEQVRHCMQTWHA----QQKVGAL 594 eIselEreADeikreirlkltsGaFLPvdRtDllelvelqDkiaDaaEdi + + ++++ +++s +D+ ++ a+d+ gi|2224615 595 LVQSF-------SKDVLVNIYS---------------AYIDNFLN-AKDA 621 AkllllkknLvsiPeelkdeflamlkktvkaaellaeaieeLekllesaf ++++k e ++ fl++l ++ + + a+ L+ gi|2224615 622 ---VRVAK-------EARPAFLKFLEQSMRE-NKEKQALSDLM------I 654 sgkEvkkardivkeieelEdeiDqlqrkllkklFsaYredainpkdflil + v+ i + E l k+l+ + ++ d +l gi|2224615 655 K---------PVQRIPRYE--------LLVKDLLK---HTPEDHPDHPLL 684 leiieklgnvSDraEDaadrisiillk<-* le +++ v+ r+ + + +++ gi|2224615 685 LEAQRNIKQVAERINK-----GVRSAE 706 SpoA: domain 1 of 1, from 645 to 711: score -25.4, E = 87 *->llalLmdipvdlvvelGrteltlreLlrLqpGsVieLdklagdpgvt + + L+d+ ++ v ++ r+el +++Ll+ +p + + ++ gi|2224615 645 EKQALSDLMIKPVQRIPRYELLVKDLLKHTPED----HPDHPLL--- 684 VdilvngrligkGelvvvgdnlGVrIteiiesk<-* ++ n + ++ ++++ GVr e e++ gi|2224615 685 LEAQRNIKQVA----ERINK--GVRSAEEAERH 711 Gastrin: domain 1 of 1, from 703 to 712: score 1.1, E = 56 *->RSaEEydyas<-* RSaEE++ ++ gi|2224615 703 RSAEEAERHA 712 DUF61: domain 1 of 1, from 686 to 794: score -64.4, E = 52 *->kvEKiikkeIealNkHLPrFkRrsLkE......LLkEkePhVtlkDG + ik e++N + rs +E +++ + L+E e+h+ + gi|2224615 686 EAQRNIKQVAERIN----K-GVRSAEEaerharVLQEIEAHIEG--- 724 keHyiKrrELEfLaelldEDeisrLrlPIvlEiesiGeeraIkIrGkvEV E+L l Lr v+E+ iG++ gi|2224615 725 ---------MEDLQAPLRRF----LRQEMVIEVKAIGGK----------- 750 KVIkkvLGkdeegylEKdelylYkPElklAEiRr...kLPTtTQviFrvs kd+ ++l d ++ k +Rr++ L T+ vi s gi|2224615 751 --------KDRSLFLFTDLIVCTTLKRKSGSLRRssmSLYTAASVIDTAS 792 ll<-* + gi|2224615 793 KY 794 Translin: domain 1 of 1, from 684 to 839: score -94.7, E = 73 *->ddkREeilKvsReItieSkklIfllqGVHrgsskdeae...erLeka +l R I + + ++ + + r++ +eae++ +L ++ gi|2224615 684 ------LLEAQRNIKQVAERINKGV----RSA--EEAErhaRVLQEI 718 rekleevKiHqhlaslkkelegedyekFsracstglQEyVEAvaFykyle + ++e+ l + ++r ++ QE V v ++ gi|2224615 719 EAHIEGME------DLQAP--------LRRFLR---QEMVIEVKAIGGKK 751 tetLpsfdelnKqLiFtTeilgienKtPssDApDkelgtWRLrinpeDYl +++L+ f +l i T++ +++ gi|2224615 752 DRSLFLFTDL----IVCTTLKRKS-------------------------- 771 LGvaDltGELrRmaltsvsnGdldeaeriskFmeqlyeeLmeleylPnkv G LrR + ++ ++ +k + +l e + k+ gi|2224615 772 -------GSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADI----IKG 810 vseLrkKldvlrqsleKveedcyalkvrgl<-* s + + + +++ ed+++l + + gi|2224615 811 ASQATNRENIQK-AISRLDEDLTTLGQMSK 839 DB: domain 1 of 1, from 939 to 1012: score -49.0, E = 64 *->CCesdrkvpeeClskkCsfntysksalnmvvqkFkqlmffkqddsCp ++ ++ +C +l sCp gi|2224615 939 --KTRSGMQFSCAA----------PTL----------------NSCP 957 lkgkalpemlfCAAqgrDHtdCClrn....GVttPqTlaGkkCLtfCdqs + pe++ C ++g C l+ + +++V + C + C+++ gi|2224615 958 E---PSPEVWVCNSDGYVGQVCLLSLraepDVEA--------CIAVCSAR 996 pgPRRFWfvtqldksYvpCldrfesIk.qCFy<-* ++ C++ + ++C++ gi|2224615 997 -----------IL-----CIGAVPGLQpRCHR 1012 Keratin_B2: domain 1 of 1, from 918 to 1029: score -91.0, E = 28 *->qtScCGfptCStlgtrPsCGsscCQPsCCeSCCQpsCcqpSCCqPtc + S+ + c+ P + P gi|2224615 918 -----RK-LASSKS--------CLDP---------EFLKAI---PIM 938 sqtscCqPtcfqssCCrPsCcqTSCCqPtCcqsssCqtgCgigGsiGyGQ + s q+ sC P+ C P+ + ++ g GQ gi|2224615 939 KTRSGMQF-----SCAAPTLNS--CPEPSPEVWVCNSDGY-------VGQ 974 eGsSGAvScrirWCRPdCrvegtClPpC..CvvsCtaPTCCqpvsaQasC + C + P ++ C+ C a + a gi|2224615 975 V----------------CLLSLRAEPDVeaCIAVCSAR----ILCIGAV- 1003 CRPsCqPyCgqsCCRPaCccsvtCtrTccePc<-* P qP C + P+ + ++ T eP gi|2224615 1004 --PGLQPRCH-REPPPSLRSPP---ETAPEPA 1029 // Start with PfamFrag (from /data/patterns/pfam) hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/pfam/PfamFrag Sequence file: tem4 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- RhoGEF RhoGEF domain 154.0 5.5e-44 1 SH2 Src homology domain 2 4.3 3.3 1 WD40 WD domain, G-beta repeat 2.5 85 1 UreD UreD urease accessory protein 2.2 19 1 NGF Nerve growth factor family 2.1 19 1 PPR PPR repeat 1.9 87 1 Gastrin Gastrin/cholecystokinin family 1.1 56 1 DX DX module 0.5 49 1 Ran_BP1 RanBP1 domain. 0.4 73 1 Ribosomal_S28e Ribosomal protein S28e 0.4 77 1 Lambda_CIII Lambda Phage CIII 0.4 92 1 HECT HECT-domain (ubiquitin-transferase). 0.0 53 1 Sua5_yciO_yrdC SUA5/yciO/yrdC family -0.1 1e+02 1 tRNA-synt_1d tRNA synthetases class I (R) -0.3 22 1 lig_chan Ligand-gated ion channel -0.5 99 1 COLFI Fibrillar collagen C-terminal domain -1.7 78 1 STAT STAT protein -2.8 79 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PPR 1/1 39 58 .. 16 35 .] 1.9 87 NGF 1/1 276 285 .. 1 10 [. 2.1 19 Sua5_yciO_yrdC 1/1 358 368 .. 179 191 .] -0.1 1e+02 COLFI 1/1 359 376 .. 1 15 [. -1.7 78 STAT 1/1 452 461 .. 616 625 .] -2.8 79 SH2 1/1 561 571 .. 69 79 .] 4.3 3.3 UreD 1/1 569 583 .. 171 185 .] 2.2 19 tRNA-synt_1d 1/1 646 660 .. 595 609 .] -0.3 22 RhoGEF 1/1 517 700 .. 1 207 [] 154.0 5.5e-44 Gastrin 1/1 703 712 .. 117 126 .] 1.1 56 Ribosomal_S28e 1/1 707 716 .. 62 71 .] 0.4 77 Ran_BP1 1/1 909 919 .. 117 127 .] 0.4 73 lig_chan 1/1 960 966 .. 1 7 [. -0.5 99 Lambda_CIII 1/1 1055 1063 .. 1 9 [. 0.4 92 HECT 1/1 1172 1190 .. 104 122 .. 0.0 53 WD40 1/1 1217 1244 .. 7 36 .] 2.5 85 DX 1/1 1329 1335 .. 95 101 .] 0.5 49 Alignments of top-scoring domains: PPR: domain 1 of 1, from 39 to 58: score 1.9, E = 87 *->leeAlelfeeMkekGikPdv<-* ++eA ++fe+++++G d+ gi|2224615 39 VQEARQVFEKIQRMGAQQDD 58 NGF: domain 1 of 1, from 276 to 285: score 2.1, E = 19 *->epvsrRGElS<-* +++srRGEl+ gi|2224615 276 SDPSRRGELA 285 Sua5_yciO_yrdC: domain 1 of 1, from 358 to 368: score -0.1, E = 1e+02 *->dltddtpvvlRrG<-* d++ p+++RrG gi|2224615 358 DIL--SPRLIRRG 368 COLFI: domain 1 of 1, from 359 to 376: score -1.7, E = 78 *->lksP....eGksrknPARt<-* ++sP+ + G s+k PAR+ gi|2224615 359 ILSPrlirRG-SKKRPARS 376 STAT: domain 1 of 1, from 452 to 461: score -2.8, E = 79 *->DLiKkHllpl<-* D++K ++l l gi|2224615 452 DVTKQYMLNL 461 SH2: domain 1 of 1, from 561 to 571: score 4.3, E = 3.3 *->FssLpeLvehY<-* F+ +peL eh+ gi|2224615 561 FDQIPELLEHH 571 UreD: domain 1 of 1, from 569 to 583: score 2.2, E = 19 *->vadeallkqlrelle<-* +++e +l+q+r++++ gi|2224615 569 EHHEQFLEQVRHCMQ 583 tRNA-synt_1d: domain 1 of 1, from 646 to 660: score -0.3, E = 22 *->angLdlLGistverM<-* +++L+ L i++v+r gi|2224615 646 KQALSDLMIKPVQRI 660 RhoGEF: domain 1 of 1, from 517 to 700: score 154.0, E = 5.5e-44 *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF v+ ll TE Yv++L++l ++ym+pL++++ s + +p ++ iF gi|2224615 517 VAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIF 561 sNiediyefhreFLkssLearisssqfedlDekkiepsaprlGdlFlkl. i++++e h +FL +++++ ++ +G+l+ ++ gi|2224615 562 DQIPELLEHHEQFLE-QVRHCMQTW-----------HAQQKVGALLVQSf 599 .kepflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgA +k+ ++Y +Y++n+ +A++ ++ ++++p+F +fl++ + + n++ gi|2224615 600 sKDVLVNIYSAYIDNFLNAKDAVRV--AKEARPAFLKFLEQSMRE-NKE- 645 kddavkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkkal k L++L++kPvqRi+rY+LL+k+LLkhtpe d+pd+++L +a+ gi|2224615 646 -----KQALSDLMIKPVQRIPRYELLVKDLLKHTPE--DHPDHPLLLEAQ 688 dllqdlaksiNe<-* ++++ +a++iN+ gi|2224615 689 RNIKQVAERINK 700 Gastrin: domain 1 of 1, from 703 to 712: score 1.1, E = 56 *->RSaEEydyas<-* RSaEE++ ++ gi|2224615 703 RSAEEAERHA 712 Ribosomal_S28e: domain 1 of 1, from 707 to 716: score 0.4, E = 77 *->EsEREARrLr<-* E ER AR L gi|2224615 707 EAERHARVLQ 716 Ran_BP1: domain 1 of 1, from 909 to 919: score 0.4, E = 73 *->FKkkFEeaqke<-* F ++F+ea+++ gi|2224615 909 FEQAFDEAKRK 919 lig_chan: domain 1 of 1, from 960 to 966: score -0.5, E = 99 *->SseiWmm<-* S+e+W++ gi|2224615 960 SPEVWVC 966 Lambda_CIII: domain 1 of 1, from 1055 to 1063: score 0.4, E = 92 *->MhfaiAGsg<-* +h+ iAGsg gi|2224615 1055 LHISIAGSG 1063 HECT: domain 1 of 1, from 1172 to 1190: score 0.0, E = 53 *->sfhDlesvDpelYnsLiki<-* s++Dl svDpe Y+s +++ gi|2224615 1172 SLEDLLSVDPEAYQSSVWL 1190 WD40: domain 1 of 1, from 1217 to 1244: score 2.5, E = 85 *->hsssvtslafdpdggllatgsaDgtvriwd<-* h +svt++ + ++ +++++ a+g + +++ gi|2224615 1217 HAASVTCILYLNN--QVFVSLANGELVVYQ 1244 DX: domain 1 of 1, from 1329 to 1335: score 0.5, E = 49 *->aeCyedP<-* ++C+++P gi|2224615 1329 HVCLYHP 1335 // Start with Repeat Library (from /data/patterns/repeats-Miguel-Andrade/hmm) hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/repeats-Miguel-Andrade/hmm/repeats.hmm-lib Sequence file: tem4 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- [no hits above thresholds] Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- [no hits above thresholds] Alignments of top-scoring domains: [no hits above thresholds] // ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with Prosite --------------------------------------------------------- | ppsearch (c) 1994 EMBL Data Library | | based on MacPattern (c) 1990-1994 R. Fuchs | --------------------------------------------------------- PROSITE pattern search started: Wed Oct 11 20:41:38 2000 Sequence file: tem4 ---------------------------------------- Sequence gi|2224615|dbj|BAA20795.1| (1510 residues): Matching pattern PS00004 CAMP_PHOSPHO_SITE: 271: KKKS 366: RRGS 768: KRKS 775: RRSS 1161: RRSS 1209: RRNS Total matches: 6 Matching pattern PS00005 PKC_PHOSPHO_SITE: 211: SPK 279: SRR 332: SER 361: SPR 369: SKK 400: SSR 531: SLR 639: SMR 766: TLK 773: SLR 815: TNR 867: SEK 922: SSK 979: SLR 994: SAR 1017: SLR 1118: SSK 1205: SIR 1212: SMK 1306: SSR 1323: TLK Total matches: 21 Matching pattern PS00006 CK2_PHOSPHO_SITE: 14: SSSE 79: SQEE 84: SGPE 89: SLTD 170: SNGE 180: SLSD 193: TSEE 220: SAMD 274: SLSD 307: SSSE 377: SHQE 449: SLED 520: TLLD 527: SYVE 555: SLVD 639: SMRE 674: TPED 704: SAEE 786: SVID 815: TNRE 825: SRLD 850: SLDD 881: TKLE 888: TRPE 925: SCLD 955: SCPE 1020: SPPE 1024: TAPE 1045: TLAE 1062: SGLE 1084: SDSD 1086: SDDE 1118: SSKE 1127: TSSE 1128: SSEE 1129: SEEE 1153: SPMD 1172: SLED 1205: SIRD 1445: TGPE 1475: SGGD 1491: SSSE Total matches: 42 Matching pattern PS00008 MYRISTYL: 108: GLGTTG 131: GTEDSL 163: GSGGSE 166: GSEFSN 215: GLPATS 225: GLTSGH 236: GSEESK 324: GATRSR 701: GVRSAE 810: GASQAT 943: GMQFSC 1001: GAVPGL 1069: GLGEGD 1096: GTLQSQ 1147: GGPCGT 1191: GTEDGC 1265: GSPITK 1303: GQDSSR 1319: GVWVTL 1384: GTSAGV 1388: GVVLTM 1411: GLGQGH 1413: GQGHTG 1488: GGGSSS 1489: GGSSSE Total matches: 25 Matching pattern PS00009 AMIDATION: 748: GGKK Total matches: 1 Total no of hits in this sequence: 95 ======================================== 1314 pattern(s) searched in 1 sequence(s), 1510 residues. Total no of hits in all sequences: 95. Search time: 00:00 min ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with Profile Search ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with motif search against own library ***** bioMotif : Version V41a DB, 1999 Nov 11 ***** SeqTyp=2 : PROTEIN search; >APC D-Box is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 1510 units ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~ ~~~ Start with HMM-search search against own library hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/own/own-hmm.lib Sequence file: tem4 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- [no hits above thresholds] Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- [no hits above thresholds] Alignments of top-scoring domains: [no hits above thresholds] // hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/own/own-hmm-f.lib Sequence file: tem4 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- [no hits above thresholds] Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- [no hits above thresholds] Alignments of top-scoring domains: [no hits above thresholds] // ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ L. Aravind's signalling DB IMPALA version 1.1 [20-December-1999] Reference: Alejandro A. Schaffer, Yuri I. Wolf, Chris P. Ponting, Eugene V. Koonin, L. Aravind, Stephen F. Altschul (1999), "IMPALA: Matching a Protein Sequence Against a Collection of "PSI-BLAST-Constructed Position-Specific Score Matrices", Bioinformatics 15:1000-1011. Query= gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] (1510 letters) Searching..................................done Results from profile search Score E Sequences producing significant alignments: (bits) Value RHOGAP RHO-type GTPase GTP hydrolysis activating protein 172 2e-45 RHOGEF RHO-type GTPase GDP exchange factor 135 3e-34 SNARE Alpha helical domains which are involved in vesicle fu... 25 0.79 HSF Heat Shock Factor Domain (Winged helix type DNA binding ... 25 0.97 POZ Pox virus Zinc finger domain (Also called BTB domain; a... 24 1.2 ARR Arrestin domain 24 1.4 KELCH Kelch repeat- beta propeller like domain 23 1.9 PAS domain (Per-Arnt-Sim Domain (A ligand binding and dimeri... 23 2.4 SEC7 Sec7 like GDP exchange factor for ARF like GTPases 23 2.8 PH Pleckstrin homology domain (lipid and protein interactio... 23 3.3 PUM Pumilio repeat RNA binding domain 23 3.3 S1 S1 RNA binding domain 22 5.0 CNMP Cyclic nucleotide binding domain 22 6.4 HECT A ubiquitin conjugating enzyme domain 22 7.5 MIZFIN MIZ type Cysteine zinc DNA binding domain 21 9.2 >RHOGAP RHO-type GTPase GTP hydrolysis activating protein Length = 194 Score = 172 bits (434), Expect = 2e-45 Identities = 32/196 (16%), Positives = 72/196 (36%), Gaps = 16/196 (8%) Query: 517 VAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIF--DQIPELLEHHEQF 574 V L+ TE +V +L+ + + + + + +P +V +F + H Sbjct: 1 VMYELIQTELHHVRTLKIMTRLFRTGMLEEL---HLEPGVVQGLFPLRGRASVTSIHASS 57 Query: 575 LEQVR-------HCMQTWHAQQKVGALLVQSFSK---DVLVNIYSAYIDNFLNAKDAVRV 624 ++G LL+ FS + + YS + A + Sbjct: 58 ASYQNADARPCALGSTGNFVIPRLGDLLISQFSGGSAEQMCKTYSEFCSRHSKALKFYKE 117 Query: 625 AKEARPAFLKFLEQSMRE-NKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPL 683 F +F+ + R ++ + + ++ QRI +Y LL+ +L+H+ + Sbjct: 118 LYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQD 177 Query: 684 LLEAQRNIKQVAERIN 699 L A +K++ ++ Sbjct: 178 LTTALGLVKELLSNVD 193 >RHOGEF RHO-type GTPase GDP exchange factor Length = 176 Score = 135 bits (339), Expect = 3e-34 Identities = 45/162 (27%), Positives = 81/162 (49%), Gaps = 15/162 (9%) Query: 517 VAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDE---IFDQIPELLE-HHE 572 V L+ TE+ YV L T++ GY + PE L P L ++ +F + E+ E H++ Sbjct: 1 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 60 Query: 573 QFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAF 632 FL + +C ++VG ++ +Y+ Y N ++ R + + Sbjct: 61 IFLSSLENCAHAP---ERVGPCFLERKD---DFQMYAKYCQNKPRSETIWR-----KYSE 109 Query: 633 LKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT 674 F ++ R+ K + L ++KPVQRI +Y+LL+K+LLK++ Sbjct: 110 CAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYS 151 >SNARE Alpha helical domains which are involved in vesicle fusion Length = 254 Score = 24.9 bits (54), Expect = 0.79 Identities = 12/88 (13%), Positives = 20/88 (22%), Gaps = 15/88 (17%) Query: 789 DTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPH 848 + + K + P + I N ++Q I S Sbjct: 117 NFIQRTKQRYNNPRSLSTKI-------NLSDMQMEIKL-RPPYQIPMCE---LGSA---- 161 Query: 849 QSLDDALRDLSAAMHRDLSEKQALCYAL 876 + A + S Q L A Sbjct: 162 NGVTSAFSVDCKGAGKISSAHQRLEPAT 189 >HSF Heat Shock Factor Domain (Winged helix type DNA binding domain) Length = 112 Score = 24.5 bits (53), Expect = 0.97 Identities = 6/27 (22%), Positives = 10/27 (36%) Query: 899 EFPHPDARLGFEQAFDEAKRKLASSKS 925 EF + G + KR+ +S Sbjct: 73 EFANEGFLGGQKHLLKTIKRRRNVGQS 99 >POZ Pox virus Zinc finger domain (Also called BTB domain; a protein-protein interaction domain) Length = 229 Score = 24.4 bits (52), Expect = 1.2 Identities = 18/150 (12%), Positives = 47/150 (31%), Gaps = 11/150 (7%) Query: 507 SKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEI-FDQIP 565 S + L+D + ++ ++ L Q + L+ E + I Sbjct: 58 SGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEI---KELMAEAKYYLIQ 114 Query: 566 ELLEHHEQFLEQVRHCMQT------WHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAK 619 L+ + L+ + Q + ++ L+ S K V+ +Y+ + + Sbjct: 115 GLVNMCQSALQDKKDSYQPVCNIPIITSLKEEERLIESST-KPVVKLLYNRSNNKYSYTS 173 Query: 620 DAVRVAKEARPAFLKFLEQSMRENKEKQAL 649 ++ + F K + + + Sbjct: 174 NSDDHLLKNIELFDKLSLRFNGRVLFIKDV 203 >ARR Arrestin domain Length = 454 Score = 24.1 bits (52), Expect = 1.4 Identities = 7/30 (23%), Positives = 15/30 (49%) Query: 875 ALSFPPTKLELCATRPEGTDSYIFEFPHPD 904 ++S P ++L+ R G +++ F F Sbjct: 117 SISRPLSRLQERLKRKLGANAFPFWFEVAP 146 Score = 21.4 bits (45), Expect = 8.7 Identities = 6/30 (20%), Positives = 9/30 (30%), Gaps = 1/30 (3%) Query: 997 ILCIGAVPGLQPRCHREPPPSLRSPPETAP 1026 L P P PS+ + + P Sbjct: 376 TLTHSK-PPESPERTDRGLPSIEATNGSEP 404 >KELCH Kelch repeat- beta propeller like domain Length = 319 Score = 23.4 bits (50), Expect = 1.9 Identities = 13/121 (10%), Positives = 36/121 (29%), Gaps = 14/121 (11%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREA 1247 + V Y ++ + + + L NQ+F+ + E + + Sbjct: 183 SVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAV--LGNQIFIMGGDTE---FSACS 237 Query: 1248 GHFWDPQNFKSVTLGTQGSPIT--KMVSVGGRL--WCGCQ-----NRVLVLSPDTLQLEH 1298 + ++ + ++ +G + V+ G +L G + P Sbjct: 238 AYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNS 297 Query: 1299 M 1299 + Sbjct: 298 I 298 >PAS domain (Per-Arnt-Sim Domain (A ligand binding and dimerization domain)) Length = 117 Score = 23.4 bits (50), Expect = 2.4 Identities = 7/88 (7%), Positives = 22/88 (24%), Gaps = 9/88 (10%) Query: 695 AERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLR--QEMVIEVKAI----G 748 E + + ++ ++ E ++ + + A+ Sbjct: 30 QELQGQPHNMVRHPDMPKAAFADMWFTLKKGEPWSGIVKNRRKNGDHYWVRANAVPMVRE 89 Query: 749 GKKDRSLFLFTDLIVCTTLKRKSGSLRR 776 GK + + T T + + Sbjct: 90 GKISGYMSIRTRA---TDEEIAAVEPLY 114 >SEC7 Sec7 like GDP exchange factor for ARF like GTPases Length = 192 Score = 22.9 bits (49), Expect = 2.8 Identities = 22/108 (20%), Positives = 43/108 (39%), Gaps = 14/108 (12%) Query: 655 KPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARV 714 KP + + L+ + + TP H LL + + + E + + + + V Sbjct: 18 KPEKGVQY--LIERGFVPDTPVGVA-HFLLQRKGLSRQMIGEFL-----GNRQKQFNRDV 69 Query: 715 LQEIEAHIE--GMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTD 760 L + ++ ME +A LR+F I V+ K +R + F+ Sbjct: 70 LDCVVDEMDFSTMELDEA-LRKFQ---AHIRVQGEAQKVERLIEAFSQ 113 Score = 21.3 bits (45), Expect = 7.9 Identities = 5/21 (23%), Positives = 10/21 (46%) Query: 1186 SSVWLGTEDGCVHVYQSSDSI 1206 S + G V +++ D+I Sbjct: 112 SQRYCICNPGVVRQFRNPDTI 132 >PH Pleckstrin homology domain (lipid and protein interaction domain) Length = 138 Score = 22.7 bits (48), Expect = 3.3 Identities = 10/103 (9%), Positives = 28/103 (26%), Gaps = 4/103 (3%) Query: 722 IEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSL 781 +G + ++ + K R L + + + + R + L Sbjct: 3 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYF--EYTTDKEPRGIIPL 60 Query: 782 YTAASVIDTASKYKMLWKL--PLEDADIIKGASQATNRENIQK 822 + + ++L P +IK + ++ Sbjct: 61 ENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEG 103 >PUM Pumilio repeat RNA binding domain Length = 337 Score = 22.9 bits (49), Expect = 3.3 Identities = 11/34 (32%), Positives = 15/34 (43%) Query: 797 LWKLPLEDADIIKGASQATNRENIQKAISRLDED 830 + LPL D D IK A+ +QK + E Sbjct: 4 ISALPLRDLDYIKLATDQFGCRFLQKKLETPSES 37 >S1 S1 RNA binding domain Length = 305 Score = 22.2 bits (47), Expect = 5.0 Identities = 8/50 (16%), Positives = 21/50 (42%), Gaps = 3/50 (6%) Query: 703 RSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKD 752 +A + A+ L + + H E + + + + + + ++ GGK Sbjct: 7 SAAFSLDEFAKALDKHDYHAEKGQTVHGKICQHANEGVYVD---FGGKSP 53 Score = 21.4 bits (45), Expect = 9.5 Identities = 10/50 (20%), Positives = 17/50 (34%), Gaps = 5/50 (10%) Query: 660 IPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAE 709 IPR L+ KD + + Q ++ R ++AE Sbjct: 142 IPRSHLMHKDNMDALVGQ--VLKAHILE---ANQDNNKLVLTQRRIQQAE 186 >CNMP Cyclic nucleotide binding domain Length = 118 Score = 21.7 bits (46), Expect = 6.4 Identities = 10/59 (16%), Positives = 16/59 (26%), Gaps = 2/59 (3%) Query: 1126 TTSSEEEQEPGFLPLSGSFGPGG--PCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPE 1182 + EQ L G G P R R S ++++ D + Sbjct: 50 ASKGVSEQVLAKLGPGSMAGEIGVVFNIPQPFTVRTRRLSQVIRIGHHKFKEMVQSDND 108 >HECT A ubiquitin conjugating enzyme domain Length = 255 Score = 21.7 bits (46), Expect = 7.5 Identities = 7/19 (36%), Positives = 10/19 (51%) Query: 1172 SLEDLLSVDPEAYQSSVWL 1190 +LEDL VD Q+ + Sbjct: 116 TLEDLEEVDLLYVQTLNSI 134 >MIZFIN MIZ type Cysteine zinc DNA binding domain Length = 172 Score = 21.1 bits (44), Expect = 9.2 Identities = 14/60 (23%), Positives = 20/60 (33%), Gaps = 5/60 (8%) Query: 1081 PFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEA-----TAETTSSEEEQEP 1135 P + S T +S + S S K+ T E++S EEE P Sbjct: 91 PMRPKKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKIDVIDLTIESSSDEEEDPP 150 Underlying Matrix: BLOSUM62 Number of sequences tested against query: 105 Number of sequences better than 10.0: 15 Number of calls to ALIGN: 18 Length of query: 1510 Total length of test sequences: 20182 Effective length of test sequences: 16136.0 Effective search space size: 23740223.4 Initial X dropoff for ALIGN: 25.0 bits Y. Wolf's SCOP PSSM IMPALA version 1.1 [20-December-1999] Reference: Alejandro A. Schaffer, Yuri I. Wolf, Chris P. Ponting, Eugene V. Koonin, L. Aravind, Stephen F. Altschul (1999), "IMPALA: Matching a Protein Sequence Against a Collection of "PSI-BLAST-Constructed Position-Specific Score Matrices", Bioinformatics 15:1000-1011. Query= gi|2224615|dbj|BAA20795.1| KIAA0337 [Homo sapiens] (1510 letters) Searching.................................................done Results from profile search Score E Sequences producing significant alignments: (bits) Value gi|2746866 [80..273] 7-bladed beta-propeller 51 1e-07 gi|1556399 [647..916] 7-bladed beta-propeller 48 1e-06 gi|2832331 [157..459] 7-bladed beta-propeller 47 2e-06 gi|2137729 [37..266] 7-bladed beta-propeller 46 5e-06 gi|2622601 [25..254] 7-bladed beta-propeller 43 3e-05 gi|2102675 [28..258] 7-bladed beta-propeller 43 4e-05 gi|1001440 [1028..1666] 7-bladed beta-propeller 43 4e-05 gi|549752 [8..246] 7-bladed beta-propeller 42 8e-05 gi|2815132 [909..1205] 7-bladed beta-propeller 42 8e-05 gi|1181604 [175..454] 7-bladed beta-propeller 40 2e-04 gi|1001939 [228..429] 7-bladed beta-propeller 40 3e-04 gi|1086900 [26..235] 7-bladed beta-propeller 37 0.002 gi|586529 [222..473] 7-bladed beta-propeller 37 0.002 gi|1363708 [373..683] 7-bladed beta-propeller 36 0.004 gi|2104446 [1048..1249] 7-bladed beta-propeller 36 0.004 gi|452523 [41..225] 7-bladed beta-propeller 35 0.007 gi|1495018 [84..244] 7-bladed beta-propeller 35 0.008 gi|2131405 [8..233] 7-bladed beta-propeller 35 0.011 gi|2736365 [143..399] 7-bladed beta-propeller 35 0.012 gi|2494897 [186..459] 7-bladed beta-propeller 32 0.059 gi|2662028 [241..421] 7-bladed beta-propeller 32 0.059 gi|2129405 [8..201] S-adenosyl-L-methionine-dependent methyl... 32 0.075 gi|1066956 [784..993] 7-bladed beta-propeller 31 0.15 gi|549660 [99..278] 7-bladed beta-propeller 29 0.68 gi|4006 [276..439] P-loop containing nucleotide triphosphate... 28 0.90 gi|135122 [4..325] Class II aaRS and biotin synthetases 28 1.0 gi|123030 [1..120] Four-helical up-and-down bundle 28 1.2 gi|121663 [123..314] ATP-grasp 28 1.3 gi|433311 [68..521] DNA/RNA polymerases 28 1.5 gi|417569 [3..336] Aspartate/ornithine carbamoyltransferase,... 27 2.1 gi|1360139 [98..407] 7-bladed beta-propeller 27 2.6 gi|1568595 [1..151] Ribosomal protein L9 26 3.1 gi|2117634 [147..843] Lipoxigenase, C-terminal domain 26 4.0 gi|125988 [12..184] EF Hand-like 26 4.9 gi|2811252 [82..382] Periplasmic binding protein-like II 25 6.2 gi|153548 [125..455] beta-Lactamase/D-ala carboxypeptidase 26 6.4 gi|2497466 [46..370] Purine nucleoside hydrolase 25 7.8 gi|2463100 [37..265] Trypsin-like serine proteases 25 7.9 gi|1938424 [576..818] Acyl-CoA dehydrogenase (flavoprotein),... 25 8.2 gi|478310 [306..563] beta/alpha (TIM)-barrel 25 8.6 gi|1420859 [36..611] Periplasmic binding protein-like II 25 9.0 gi|68234 [34..414] Citrate synthase 25 9.4 gi|544020 [86..429] Nitrogenase iron-molybdenum protein, alp... 25 9.7 >gi|2746866 [80..273] 7-bladed beta-propeller Length = 194 Score = 51.2 bits (121), Expect = 1e-07 Identities = 28/190 (14%), Positives = 56/190 (28%), Gaps = 25/190 (13%) Query: 1191 GTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHF 1250 +G + + + D N + H VT ++ +N F+S + V Sbjct: 10 AGRNGTLTHWMFNHEPGDLPNVVFDGHKFGVTGVVSINENQFMSGSRDCSV-------KI 62 Query: 1251 WDPQNFKSV-TLGTQGSPITKMVSVGGRLWCGCQNR-VLVLSPDTLQLEHMFYVGQDSSR 1308 WD ++ K V T + +T M G + +++ V + P + F + Sbjct: 63 WDLESAKCVRTQTINRNLVTHMAYNGNLVAQTSEDKSVRLWDPRNASVVTEFPRKRHIQM 122 Query: 1309 CVA--------------CMVDSSLGVWVTLKGS-AHVCLYHPDTFEQLAEVDVTPPVHRM 1353 + + + H L+ V + + Sbjct: 123 FCEFDGANRFFSCSNGFNNDGCEITSYDVRNPRQSREARGHEGNVTSLSIVQMDQTKRLL 182 Query: 1354 LAGS-DAIIR 1362 + S D IR Sbjct: 183 ASVSADRQIR 192 >gi|1556399 [647..916] 7-bladed beta-propeller Length = 270 Score = 48.1 bits (113), Expect = 1e-06 Identities = 21/163 (12%), Positives = 48/163 (28%), Gaps = 10/163 (6%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREA 1247 V + D V+ Y + R H +V+ I + +N+++ + + + V+ Sbjct: 41 VITSSWDNNVYFYSIAFGRRQDTLMG---HDDAVSKICWHDNRLYSASWDSTVKVWSGVP 97 Query: 1248 GHFWDPQNFKSVTLGTQG--SPITKM-VSVGGRL--WCGCQNRVLVLSPDTLQLEHMFYV 1302 + L + + ++ L + V + T L H Sbjct: 98 AEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPC 157 Query: 1303 GQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVD 1345 A DS + G + + T ++ + Sbjct: 158 HSGIVCDTAFSPDSRHVLSTGTDGC--LNVIDVQTGMLISSMT 198 >gi|2832331 [157..459] 7-bladed beta-propeller Length = 303 Score = 47.4 bits (111), Expect = 2e-06 Identities = 32/254 (12%), Positives = 77/254 (29%), Gaps = 34/254 (13%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYL--NNQVFVSLANGELVVYQR 1245 + G + ++++ + H +V+ + + +Q++ + + + V Sbjct: 58 LASGDRSKLILIWEAQSCQHLYTFTG---HRDAVSGLAFRRGTHQLYSTSHDRSVKV--- 111 Query: 1246 EAGHFWDPQNFKSV-TLGTQGSPIT--KMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYV 1302 W+ V TL + +S + G ++ + + + + +FY Sbjct: 112 -----WNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYG 166 Query: 1303 GQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIR 1362 Q S C+ + + + V+ V L+ LA + Sbjct: 167 HQGSIDCIHLINEEHM---VSGADDGSVALWGLSKKRPLALQREAHGLRGE------PGL 217 Query: 1363 QHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRF 1422 + + A L+ +L+ G+ + V G + L G + Sbjct: 218 EQPFWISSV-AALLNTDLVATGSHSSCVRLWQCGEGF---RQLDLLCD---IPLVGFINS 270 Query: 1423 LAAVQLPDGFNLLC 1436 L G L+ Sbjct: 271 LKF--SSSGDFLVA 282 >gi|2137729 [37..266] 7-bladed beta-propeller Length = 230 Score = 45.7 bits (107), Expect = 5e-06 Identities = 21/195 (10%), Positives = 50/195 (24%), Gaps = 31/195 (15%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYL--NNQVFVSLANGELVVYQR 1245 + + G V S ++L TC+ + + N + + Sbjct: 13 LVTASSSGDKIVVSSCKC--KPVPLLELAEGQKQTCVDLNSTSMYLASGGLNNTVNI--- 67 Query: 1246 EAGHFWDPQNFKSV-TLGTQGSPITKM--VSVGGRLWCGCQNRVL-------------VL 1289 WD ++ + +L +T + + G + + Sbjct: 68 -----WDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFG 122 Query: 1290 SPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPP 1349 + H+ Y S + + + +W S++ + +P Sbjct: 123 HGSKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVNSQSSYHTFDSTHKAPASG-ICFSPV 181 Query: 1350 VHRMLA--GSDAIIR 1362 + G D I Sbjct: 182 NELLFVTIGLDKRII 196 >gi|2622601 [25..254] 7-bladed beta-propeller Length = 230 Score = 43.3 bits (101), Expect = 3e-05 Identities = 16/157 (10%), Positives = 42/157 (26%), Gaps = 19/157 (12%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQ-HAASVTCILYLNNQVFVSLANGELVVYQRE 1246 V++G+ DG ++ K + + + V++ + + Sbjct: 87 VFVGSWDGYLYAI----DTDTGDLEWKFKTGNRIESSPAVSGDTVYIGSDDCRVYA---- 138 Query: 1247 AGHFWDPQNFKSV-TLGTQGSPITKMVSVGGRLWCGCQ-NRVLVLSPDTLQLEHMFYVGQ 1304 D + T + + + V G L+ G +V LS + Sbjct: 139 ----VDRDDGSKKWEFYTGDAVKSSPLPVNGTLYVGSFNGKVYALSESDGNEVWSYT--S 192 Query: 1305 DSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQL 1341 + + + + G+ + + Sbjct: 193 GDAIRSSPAFWNGTVYVGSDDGN--IYALSESDGNVI 227 >gi|2102675 [28..258] 7-bladed beta-propeller Length = 231 Score = 43.0 bits (100), Expect = 4e-05 Identities = 16/165 (9%), Positives = 42/165 (24%), Gaps = 20/165 (12%) Query: 1191 GTEDGCVHVYQSSDSIRDRRNSMKLQ-HAASVTCILYLNNQVFVSLANGELVVYQREAGH 1249 DG + ++ + + + + + V A + Sbjct: 4 CGSDGDIRIW-------ESLDDDDPKSISIGEKAYSFALKNGKVVTAASNNAIQ------ 50 Query: 1250 FWDPQNFKSV-TLGTQGSPITKMV--SVGGRLWCGCQNRVL-VLSPDTLQLEHMFYVGQD 1305 + + L + +V + G R+ G + ++ VL + + Sbjct: 51 LHTFPDGEPDGILTRFTTNANHVVFNTDGTRIAAGSGDFLVKVLQVEDSTQQKTLRGHSA 110 Query: 1306 SSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPV 1350 V+ + GS V ++ A + + Sbjct: 111 PVLSVSFDPKDIYLASASCDGS--VRIWKISDQTCEAVLPLLEKC 153 >gi|1001440 [1028..1666] 7-bladed beta-propeller Length = 639 Score = 42.5 bits (98), Expect = 4e-05 Identities = 26/205 (12%), Positives = 46/205 (21%), Gaps = 18/205 (8%) Query: 1143 SFGP-GGPCGTSPMDGRALRRSSHG---SFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVH 1198 F G T+ D A G RG + A + + D Sbjct: 445 EFSADGQFIVTASDDNTAGIWEIVGREVGICRGHEGPVYFAQFSADSRYILTASVDNTAR 504 Query: 1199 VYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKS 1258 ++ R H + V + ++ + + WD Sbjct: 505 IW----DFLGRPLLTLAGHQSIVYQARFSPEGNLIATVSADHTA------RLWDRSGKTV 554 Query: 1259 VTLGTQGSPITKMV--SVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDS 1316 L + + G L + L + + + R D Sbjct: 555 AVLYGHQGLVGTVDWSPDGQMLVTASNDGTARLWDLSGRELLTLEGHGNWVRSAEFSPDG 614 Query: 1317 SLGVWVTLKGSAHVCLYHPDTFEQL 1341 +T L+ T QL Sbjct: 615 RW--VLTSSADGTAKLWPVKTLPQL 637 Score = 41.7 bits (96), Expect = 8e-05 Identities = 20/234 (8%), Positives = 55/234 (22%), Gaps = 12/234 (5%) Query: 1171 GSLEDLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQ 1230 G + + + + + + + DG ++ + R + H + V + + Sbjct: 108 GHADWVRNAEFNCHGQILLTASRDGTARLW----DLEGREIGLCQGHTSWVRNAQFSPDG 163 Query: 1231 VFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMV--SVGGRLWCGCQNRVLV 1288 ++ + + WD + L + + + G + + Sbjct: 164 QWIVTCSADGTA------RLWDLSSQCFAVLKGHQNWVNNALWSPDGQHIITSSSDGTAR 217 Query: 1289 LSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTP 1348 + + + +D V + +A + L Sbjct: 218 VWSRHGKCLGTLRGHDHNIHGARFSLDGQKIVTYSTDNTARLWTKEGTLLTILRGHQKEV 277 Query: 1349 PVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSC 1402 A + R + + + G S V G Sbjct: 278 YDADFSADGRFVFTVSADQTARQWDISQKDTITLTGHSHWVRNAHFNPKGDRLL 331 Score = 29.3 bits (64), Expect = 0.43 Identities = 11/103 (10%), Positives = 31/103 (29%), Gaps = 16/103 (15%) Query: 1191 GTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNN--QVFVSLANGELVVYQREAG 1248 T +G +++ S ++ H ++T + + + + A+ + + Sbjct: 5 ATTNGIAYLW----SFHGELINVLRGHQEAITALDWSADGQYFATASADHTVKL------ 54 Query: 1249 HFWDPQNFKSVTLGTQGSPITKMV--SVGGRLWCGCQNRVLVL 1289 W + TL + + L Q+ + Sbjct: 55 --WQRHGEEVATLRGHEDWVRSVHFSPHHQFLVTSGQDNTARI 95 >gi|549752 [8..246] 7-bladed beta-propeller Length = 239 Score = 41.9 bits (97), Expect = 8e-05 Identities = 18/188 (9%), Positives = 49/188 (25%), Gaps = 25/188 (13%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREA 1247 + G +D ++ + + + H +V + + + V + V Sbjct: 62 LLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKV----- 116 Query: 1248 GHFWDPQNFKSVTLGTQGSPITKMV---SVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQ 1304 W + + + ++ + L ++ F Sbjct: 117 ---WKEGSLVYNLQAHNA-SVWDAKVVSFSENKFLTASADKTIKLW-QNDKVIKTFSGIH 171 Query: 1305 DSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAE----------VDVTPPVHRML 1354 + V + G +++ + L T + L + + P + Sbjct: 172 NDV--VRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDIVS 229 Query: 1355 AGSDAIIR 1362 G D +R Sbjct: 230 CGEDRTVR 237 >gi|2815132 [909..1205] 7-bladed beta-propeller Length = 297 Score = 41.6 bits (96), Expect = 8e-05 Identities = 23/190 (12%), Positives = 52/190 (27%), Gaps = 18/190 (9%) Query: 1152 TSPMDGRA----LRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIR 1207 T D + S G + + ++ + + V + ED + V+ S Sbjct: 117 TGSGDFVVQMWDVTNGKCISRMGGLMAPVSTLAITSNDAFVVVACEDETLKVF----STV 172 Query: 1208 DRRNSMKLQ-HAASVTCILYL-NNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQG 1265 + +L H V ++ ++ + ++ Y G V Q Sbjct: 173 GGQELHELMGHEGKVNSLVCAQDDCQLFAATKSKVFCYDIHNGQ------MIDVLDTAQP 226 Query: 1266 SPITKMVSVGGRLW--CGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVT 1323 PI + + C +V + + + A + + Sbjct: 227 FPICSLKISSDNYFLISPCGPKVTIWNVTKRNHDAHDVHADKEGFLTAVALSNDDKYAAC 286 Query: 1324 LKGSAHVCLY 1333 + V L+ Sbjct: 287 GTNNGIVALW 296 Score = 28.4 bits (62), Expect = 0.99 Identities = 14/122 (11%), Positives = 30/122 (24%), Gaps = 16/122 (13%) Query: 1251 WDPQNFKSV-TLGTQGSPITKM-VSVGGRL--WCGCQNRVLVLSPDTLQLEHMFYVGQDS 1306 + + + + T + +T + S L V V Sbjct: 1 YHIASEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAK 60 Query: 1307 SRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAE----------VDVTPPVHRMLAG 1356 C D + + S + +T E + + +T ++ G Sbjct: 61 VTCAILTSDDQYLITASADSS--AKMIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITG 118 Query: 1357 SD 1358 S Sbjct: 119 SG 120 Score = 26.0 bits (56), Expect = 3.8 Identities = 13/63 (20%), Positives = 23/63 (35%), Gaps = 5/63 (7%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYL--NNQVFVSLANGELVVYQR 1245 + D V+V+ S S H A VTC + + + + A+ + + Sbjct: 31 FVSTSFDKTVNVWVFSQSTPTMS---LTHHTAKVTCAILTSDDQYLITASADSSAKMIKL 87 Query: 1246 EAG 1248 E G Sbjct: 88 ETG 90 >gi|1181604 [175..454] 7-bladed beta-propeller Length = 280 Score = 40.4 bits (93), Expect = 2e-04 Identities = 17/197 (8%), Positives = 51/197 (25%), Gaps = 27/197 (13%) Query: 1178 SVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYL--NNQVFVSL 1235 S+ P A+ + +V D + N ++ V I + ++ Sbjct: 1 SLTPIAHIVKFGSAATESHANVTDIHDGLDFSSNDDG-GYSFGVFSIKFSTDGREIVAGT 59 Query: 1236 ANGELVVYQREAGHFWDPQNFKSV-TLGTQGSPITKMV---SVGGRLWCGCQNRVLVL-- 1289 ++ + V +D + + + S + + G ++ G + + + Sbjct: 60 SDESICV--------YDLEADRLSLRISAHESDVNSVCFADESGHLIYSGSDDNLCKVWD 111 Query: 1290 ---SPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAE--- 1343 + + + + D + + + L+ A Sbjct: 112 RRCFNAKGKPAGILMGHLEGITFIDSRGDGRYFISNGKDQT--IKLWDIRKMSSNAGGTI 169 Query: 1344 --VDVTPPVHRMLAGSD 1358 + M + Sbjct: 170 QSRNSEWDYRWMEYPQE 186 >gi|1001939 [228..429] 7-bladed beta-propeller Length = 202 Score = 39.9 bits (92), Expect = 3e-04 Identities = 19/186 (10%), Positives = 48/186 (25%), Gaps = 18/186 (9%) Query: 1191 GTEDGCVHVY--QSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLA-NGELVVYQREA 1247 + + +H++ + + R L + + + + + N + V+ Sbjct: 9 SSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTSR 68 Query: 1248 GHFWDPQNFKSVTLGTQGSPITKM--VSVGGRLWCGCQ-NRVLVLSPDTLQLEHMFYVGQ 1304 Q I+ + CG + + + D + Q Sbjct: 69 PGRDCEVRATFAKKQGQSGIISCIAFSPSQPLYACGSYGRTLGLYAWDDGSPLALLGGHQ 128 Query: 1305 DSSRCVA-----------CMVDSSLGVWVTLKGSAHVCLY-HPDTFEQLAEVDVTPPVHR 1352 + D+ L W + + T Q D+ P Sbjct: 129 GGITHLCFHPDGNLFFSGARKDAELLCWDLRQPGHLLWSLSREVTTNQRIYFDLDPSGQF 188 Query: 1353 MLAGSD 1358 +++G+ Sbjct: 189 LVSGNT 194 >gi|1086900 [26..235] 7-bladed beta-propeller Length = 210 Score = 37.1 bits (85), Expect = 0.002 Identities = 18/163 (11%), Positives = 48/163 (29%), Gaps = 17/163 (10%) Query: 1176 LLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQ-HAASVTCILY--LNNQVF 1232 + +V S V+ G+ D + + R R + ++ + +++ Sbjct: 59 VNAVAFNEESSVVFSGSMDCTMQAF----DCRSRSEKPIQIFNESTDGILSIDVNGHEIV 114 Query: 1233 VSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLW--CGCQNRVLVLS 1290 A+G + ++ S + + V ++ Sbjct: 115 AGSADGNY--------RVYSIRDGNMTVDYMGDSVNSVSFTPDSNCLLAGVMGGIVRLID 166 Query: 1291 PDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLY 1333 + +L + Q++ + C V S+ + V +Y Sbjct: 167 KSSGKLLASYKGHQNTEYKLDCRVLQSIEHVASGSEDGFVYVY 209 >gi|586529 [222..473] 7-bladed beta-propeller Length = 252 Score = 36.9 bits (84), Expect = 0.002 Identities = 21/146 (14%), Positives = 40/146 (27%), Gaps = 18/146 (12%) Query: 1191 GTEDGCVHVYQSSDSIRDRRNSMKLQ-HAASVTCILYL--NNQVFVSLANGELVVYQREA 1247 G + VY I ++ + KL H ++ + + N + + +G L + Sbjct: 114 PGPKGAIFVY----QITEKTPTGKLIGHHGPISVLEFNDTNKLLLSASDDGTLRI----- 164 Query: 1248 GHFWDPQNFKSV-TLGTQGSPITKM-VSVGGRLWCGCQ-NRVLVLSPDTLQLEHMFYVGQ 1304 W N S + I ++ V + S L + V Sbjct: 165 ---WHGGNGNSQNSFYGHSQSIVSASWVGDDKVISCSMDGSVRLWSLKQNTLLALSIVDG 221 Query: 1305 DSSRCVACMVDSSLGVWVTLKGSAHV 1330 D + G +V Sbjct: 222 VPIFAGRISQDGQKYAVAFMDGQVNV 247 Score = 28.3 bits (62), Expect = 0.94 Identities = 17/107 (15%), Positives = 36/107 (32%), Gaps = 13/107 (12%) Query: 1221 VTCILYL--NNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKM-VSVGGR 1277 VTC+ + N + + NGEL + W+ L +PI + + G Sbjct: 2 VTCLAWSHDGNSIVTGVENGELRL--------WNKTGALLNVLNFHRAPIVSVKWNKDGT 53 Query: 1278 --LWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWV 1322 + +N ++ + + + F + + + S G Sbjct: 54 HIISMDVENVTILWNVISGTVMQHFELKETGGSSINAENHSGDGSLG 100 >gi|1363708 [373..683] 7-bladed beta-propeller Length = 311 Score = 36.1 bits (82), Expect = 0.004 Identities = 17/151 (11%), Positives = 35/151 (22%), Gaps = 21/151 (13%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQ----HAASVTCILYLNNQVFVSLANGELVVY 1243 + + D V V+ + H V I + + ++ + + Sbjct: 174 LAISLLDNTVKVF-------FLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIK 226 Query: 1244 QREAGHFWDPQNFKSV-TLGTQGSPITKM-VSVGGRLW--CGCQNRVLVLSPDTLQLEHM 1299 W +L I + + C V + + Sbjct: 227 ------IWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQK 280 Query: 1300 FYVGQDSSRCVACMVDSSLGVWVTLKGSAHV 1330 Y Q +A D V + S + Sbjct: 281 LYAHQSEVWALAVATDGGFVVSSSHDHSIRI 311 Score = 36.1 bits (82), Expect = 0.005 Identities = 28/209 (13%), Positives = 54/209 (25%), Gaps = 27/209 (12%) Query: 1217 HAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMV--SV 1274 V I ++ ++ A+ + W+ + K + + Sbjct: 18 QRTDVRSIDISDDNKLLATASNGSL-------KIWNIKTHKCIRTF-ECGYALTCKFLPG 69 Query: 1275 GGRLWCGCQNRVLVL-------SPDTLQLEHMFYVG-----QDSSRCVACMVDSSLGVWV 1322 G + G +N L L DT++ H + D R V D ++ W Sbjct: 70 GLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWD 129 Query: 1323 TLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLW 1382 ++ V L T +R +LL ++ Sbjct: 130 FKVENSLVPGTKNKFLPVLKLHHDTTLELT---DDILCVRVSPDDRYLAISLLDNTVKVF 186 Query: 1383 VGTSAGVVLTMPTSPGTVSCPRAPLSPTG 1411 S L++ V +S Sbjct: 187 FLDSMKFYLSLYGHKLPVLSID--ISFDS 213 >gi|2104446 [1048..1249] 7-bladed beta-propeller Length = 202 Score = 36.0 bits (82), Expect = 0.004 Identities = 13/151 (8%), Positives = 34/151 (21%), Gaps = 15/151 (9%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQ--HAASVTCILYL---NNQVFVSLANGELVV 1242 + + + + ++ L + S+T + N + ++G L V Sbjct: 57 LLVAGDVRVIRIW----DASKEICYANLPVRSSNSITSLTSDLVGCNIIVAGFSDGVLRV 112 Query: 1243 YQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLW---CGCQNRVLVLSPDTLQLEHM 1299 Y + V + + G V + Sbjct: 113 YDKRLPARDSL---TDVWKEHSSEIVNVEMQSSGMRELISASSDGEVKLWDIRMNHSLQT 169 Query: 1300 FYVGQDSSRCVACMVDSSLGVWVTLKGSAHV 1330 F + + + + S + Sbjct: 170 FSTDNSGLTSLTVHSHAPVYATGSSNQSIKI 200 >gi|452523 [41..225] 7-bladed beta-propeller Length = 185 Score = 35.2 bits (80), Expect = 0.007 Identities = 19/145 (13%), Positives = 46/145 (31%), Gaps = 11/145 (7%) Query: 1170 RGSLEDLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYL-N 1228 + +V + LGT G + +Y + + H V CI + + Sbjct: 48 QRKKRKSEAVGMSNQTDLLALGTAVGSILLYSTVKGELHSKLISG-GHDNRVNCIQWHQD 106 Query: 1229 NQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGT-QGSPITKM-VSVGGRLWCGCQNRV 1286 + S ++ + + W+ Q K S ++ + +S G++ + Sbjct: 107 SGCLYSCSDDKHI-------VEWNVQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTI 159 Query: 1287 LVLSPDTLQLEHMFYVGQDSSRCVA 1311 + +T ++ F + Sbjct: 160 KLWVLETKEVYRHFTGHATPVSSLM 184 >gi|1495018 [84..244] 7-bladed beta-propeller Length = 161 Score = 35.1 bits (80), Expect = 0.008 Identities = 20/139 (14%), Positives = 48/139 (34%), Gaps = 15/139 (10%) Query: 1191 GTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYL--NNQVFVSLANGELVVYQREAG 1248 + D + + + S DR++ + H SV I + + VFV+ V Sbjct: 29 ISGDSTIRCWDLNQSTLDRKSQVFFGHEGSVRSICFAPDDPNVFVTGGRDFQV------- 81 Query: 1249 HFWDPQNFKSVTLGTQG--SPITKMV--SVGGRLW--CGCQNRVLVLSPDTLQLEHMFYV 1302 WD + + + IT ++ +++ + + ++ + ++ Sbjct: 82 KIWDMRVSTVKKMEEDCRMATITYKTAHPKPSKVLTSGTPKSKAKAKTIEGYKVTSVLFL 141 Query: 1303 GQDSSRCVACMVDSSLGVW 1321 + + DS + VW Sbjct: 142 DEHHVASASENADSGIRVW 160 >gi|2131405 [8..233] 7-bladed beta-propeller Length = 226 Score = 34.8 bits (79), Expect = 0.011 Identities = 15/202 (7%), Positives = 51/202 (24%), Gaps = 31/202 (15%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQ-----HAASVTCILYL--NNQVFVSLANGEL 1240 + G+ D + + S++ ++ H ++ + + + + + + Sbjct: 20 LATGSTDRKIKLV----SVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTV 75 Query: 1241 VVYQREAGHFWDPQNFKSVTLGTQGSPITKM--VSVGGRLWCGCQ-NRVLVLSPDTLQLE 1297 ++ +E + + + + + + G L + V + D E Sbjct: 76 SIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEE 135 Query: 1298 HMFYVG--------------QDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAE 1343 + + + D ++ +W + Sbjct: 136 YECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWS 195 Query: 1344 VDVTPPVHRML---AGSDAIIR 1362 D D+ +R Sbjct: 196 SDFDKTEGVFRLCSGSDDSTVR 217 >gi|2736365 [143..399] 7-bladed beta-propeller Length = 257 Score = 34.5 bits (78), Expect = 0.012 Identities = 21/254 (8%), Positives = 50/254 (19%), Gaps = 40/254 (15%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQ-HAASVTCILYL-------NNQVFVSLANGE 1239 + G+ D + + ++ M+L H +V ++++ V N Sbjct: 13 LATGSNDKTIRLMAFNEDSCRIGAEMELTCHDGTVRDLIFIESSINRSTILVSGGAGNCH 72 Query: 1240 LVVYQREAGH-FWDPQNFKSVTLGTQGSPITKMVSVGG-----RLWC---GCQNRVLVLS 1290 L V G + + + + Sbjct: 73 LNVTDCNTGQLIQSMKGHTGSCMIVHLMLKISVTKFHILNCTVKTMIYHKTFSTLFHSFR 132 Query: 1291 PDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPV 1350 D + + V + + + + Sbjct: 133 EDEKVQKSGSLGLPPILGLYTWSQAGNQFVSCSQDK--TIRFWDLRQQTAVN-------- 182 Query: 1351 HRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPT 1410 I + + + + +LL G V + Sbjct: 183 --------VISPGNASPVTSV-CVDPNGKLLVSGHEDASVALFDIGGNRILQTF----RY 229 Query: 1411 GLGQGHTGHVRFLA 1424 H VR + Sbjct: 230 LRSLPHGDEVRTVR 243 >gi|2494897 [186..459] 7-bladed beta-propeller Length = 274 Score = 32.1 bits (72), Expect = 0.059 Identities = 27/274 (9%), Positives = 57/274 (19%), Gaps = 59/274 (21%) Query: 1188 VWLGTEDGCVHVYQ--------------SSDSIRDRRNSMKLQ----HAASVTCILY--L 1227 + +G + V+ S S + ++ K H +V + + L Sbjct: 23 IAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLSKKKKKKGKKSSSAEGHTDAVLDLSWNKL 82 Query: 1228 NNQVFVSLANGELVVYQREAGHFWDPQNFKSV-TLGTQGSPITKMV--SVGGRLW--CGC 1282 V S + V WD K +L + + + Sbjct: 83 IRNVLASASADNTV-------ILWDMSLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSY 135 Query: 1283 QNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLA 1342 V + + H + V S + V + + + Sbjct: 136 DKSVALYDCRSPDESHRMWRFSGQIERVTWNHFSPCHF-LASTDDGFVYNLDARSDKPIF 194 Query: 1343 EVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSC 1402 + H + + L ++ V Sbjct: 195 T-----------------LNAHNDEISGLDLSSQIKGCLVTASADKYVKIWDILGDR--- 234 Query: 1403 PRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLC 1436 S G + + PD + Sbjct: 235 ----PSLVHSRDMKMGVLFCSSC--CPDLPFIYA 262 >gi|2662028 [241..421] 7-bladed beta-propeller Length = 181 Score = 32.4 bits (73), Expect = 0.059 Identities = 12/150 (8%), Positives = 32/150 (21%), Gaps = 25/150 (16%) Query: 1186 SSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQ-HAASVTCILYLNNQVFVSLANGELVVYQ 1244 + + + H A + + + N +S + + Sbjct: 40 TCSSDPNNPKLNLKA----PVFSEAPIREYAGHTADILDLSWSRNNFLLSSSMDKTA--- 92 Query: 1245 REAGHFWDPQNFKSVTLGTQGSPITKMV--SVGGRLW--CGCQNRVLVLSPDTLQL---- 1296 W P + +T + R + ++ + S + Sbjct: 93 ----RLWHPVRKDCLCCFEHSDFVTSIAFHPKDDRFFLSGSLDCKLRLWSIKEKAVSFWN 148 Query: 1297 EHMFYV-----GQDSSRCVACMVDSSLGVW 1321 E + D +A + Sbjct: 149 ELPELITAVAFSPDGGLAIAGTFVGLCLFY 178 >gi|2129405 [8..201] S-adenosyl-L-methionine-dependent methyltransferases Length = 194 Score = 31.8 bits (72), Expect = 0.075 Identities = 14/58 (24%), Positives = 20/58 (34%), Gaps = 3/58 (5%) Query: 661 PRYELL--VKDLLKHTPEDHPDHPLLL-EAQRNIKQVAERINKGVRSAEEAERHARVL 715 P + LL VK+ P D +P E + V E+ E + VL Sbjct: 114 PEHVLLENVKEFRSWGPIDEDGNPTKDGSIFERWISTLEALGYSVVYDEKDEDYGVVL 171 >gi|1066956 [784..993] 7-bladed beta-propeller Length = 210 Score = 31.0 bits (69), Expect = 0.15 Identities = 15/145 (10%), Positives = 39/145 (26%), Gaps = 18/145 (12%) Query: 1188 VWLGTEDGCVHVYQSSDSIRDRRNSMKLQ-HAASVTCILYL-NNQVFVSLANGELVVYQR 1245 +W + + L H AS++ + + + VS ++ Sbjct: 73 LWHWNGTTGFIAGEYNQPGEVPSPRSILTGHEASISALCVSAEHGLVVSGCEDGVI---- 128 Query: 1246 EAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVL----SPDTLQLEHMFY 1301 + + G +S L ++ +V + ++ Sbjct: 129 ---LIHTTSSDLLRRIRGHGIVTQLSMSRECILLSLFDSKRMVTYSATAKKLDEVLVDDK 185 Query: 1302 VG-----QDSSRCVACMVDSSLGVW 1321 + +D V V+ + +W Sbjct: 186 IECVTVTRDGEFAVTGAVNGRINIW 210 >gi|549660 [99..278] 7-bladed beta-propeller Length = 180 Score = 28.6 bits (63), Expect = 0.68 Identities = 12/107 (11%), Positives = 31/107 (28%), Gaps = 12/107 (11%) Query: 1191 GTEDGCVHVYQSSDSIRDRRNSMK--LQHAASVTCILYL-NNQVFVSLANGELVVYQREA 1247 E+ + +Y +K + + + N + + ++ Sbjct: 74 NPENFEIGLYNLKKIQEGPFLIIKINDATFSQWNKLEFSNNGKYLLVGSSIGKH------ 127 Query: 1248 GHFWDPQNFKSVTL--GTQGSPITKMVSVGGRLWCGCQNRVLVLSPD 1292 +D + + GT+ P+ + + G + VL D Sbjct: 128 -LIFDAFTGQQLFELIGTRAFPMREFLDSGSACFTPDGEFVLGTDYD 173 >gi|4006 [276..439] P-loop containing nucleotide triphosphate hydrolases Length = 164 Score = 28.4 bits (62), Expect = 0.90 Identities = 6/77 (7%), Positives = 20/77 (25%), Gaps = 5/77 (6%) Query: 1184 YQSSVWLGTEDGCVHVYQSSDSI---RDRRNSMKLQHAASVTCILYLNNQVFVSLANGEL 1240 ++ D C+ + +D + + I+ + N+ L + + Sbjct: 71 DRAKKKSVQSDLCLFIVDPTDLSKLLPEDILAHLSSKTFGNKRIIIVVNK--SDLVSDDE 128 Query: 1241 VVYQREAGHFWDPQNFK 1257 + + Sbjct: 129 MTKVLNKLQTRLGSKYP 145 >gi|135122 [4..325] Class II aaRS and biotin synthetases Length = 322 Score = 28.2 bits (62), Expect = 1.0 Identities = 25/218 (11%), Positives = 52/218 (23%), Gaps = 39/218 (17%) Query: 698 INKGVRSAEEAERHARVLQEIEAHI------EGMEDLQAPLRRFLRQ-----EMVIEVKA 746 I R + R ++ + + +L R+ R + +E+ + Sbjct: 105 IGPMFRHERPQKGRYRQFHQLGCEVFGLQGPDIDAELIMLTARWWRALGISEHVTLELNS 164 Query: 747 IGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDAD 806 IG + R L + L + ++L E Sbjct: 165 IGSLEAR----------ANYRDALVAFLEQHKEKLDEDCKRRMYTNPLRVLDSKNPEVQA 214 Query: 807 IIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDL 866 ++ A + +E + KL ES G + + D Sbjct: 215 LLNDAPALGDYL--------DEESREHFAGLCKLLESAGIAYTV------NQRLVRGLDY 260 Query: 867 -SEKQALCYALSFPPTKLELCATRPEGTDSYIFEFPHP 903 + S R +G + + Sbjct: 261 YNRTVFEWVTNSLGSQGTVCAGGRYDG---LVEQLGGR 295 >gi|123030 [1..120] Four-helical up-and-down bundle Length = 120 Score = 27.7 bits (61), Expect = 1.2 Identities = 14/47 (29%), Positives = 17/47 (35%), Gaps = 10/47 (21%) Query: 563 QIPELLEH---HEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVN 606 E H HE FL +R A L ++KD LVN Sbjct: 68 YKSEHPGHKKKHEDFLAVIRG----LSAPVPNDKL---LYAKDWLVN 107 >gi|121663 [123..314] ATP-grasp Length = 192 Score = 27.7 bits (61), Expect = 1.3 Identities = 16/144 (11%), Positives = 37/144 (25%), Gaps = 13/144 (9%) Query: 617 NAKDAVRVAKEARPAFLKFLEQSMRENKEK-QALSDLMIKPV-------QRIPRYELLVK 668 N K + P L ++ + K + SD+++KP+ + Sbjct: 1 NEKLFTAWFSDLTPETLVT--RNKAQLKAFWEKHSDIILKPLDGMGGASIFRVKEGDPNL 58 Query: 669 DLLKHTPEDHPDHPLLLEAQRNIKQ---VAERINKGVRSAEEAERHARVLQEIEAHIEGM 725 ++ T +H + + + + G R + + G Sbjct: 59 GVIAETLTEHGTRYCMAQNYLPAIKDGDKRVLVVDGEPVPYCLARIPQGGETRGNLAAGG 118 Query: 726 EDLQAPLRRFLRQEMVIEVKAIGG 749 PL + + Sbjct: 119 RGEPRPLTESDWKIARQIGPTLKE 142 >gi|433311 [68..521] DNA/RNA polymerases Length = 454 Score = 27.7 bits (61), Expect = 1.5 Identities = 13/99 (13%), Positives = 36/99 (36%), Gaps = 6/99 (6%) Query: 488 KPPEAARPADEPTPASKCCSKP-QVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQP 546 +P T +K P + + + + + Y +L ++Q + + Sbjct: 114 PLDPDYQPYTAFTLPNKNNQGPGRRYVWCSLPQGWVLSPLIYQSTLDNILQPWRK----- 168 Query: 547 ENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTW 585 + + +D+I+ HE+ ++++R + W Sbjct: 169 KYPNIDVYQYMDDIYIGSDFSRLEHEKIIQELRDLLIFW 207 >gi|417569 [3..336] Aspartate/ornithine carbamoyltransferase, Catalytic-chain Length = 334 Score = 27.2 bits (60), Expect = 2.1 Identities = 12/95 (12%), Positives = 25/95 (25%), Gaps = 9/95 (9%) Query: 1256 FKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVD 1315 F + T+ S ++ L+ ++ D+ +A + Sbjct: 57 FLEPSTRTKESFRNAAKFHQV--------KLSDLAAESSSFNKGESY-ADTFNTLAGYQN 107 Query: 1316 SSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPV 1350 S V ++G F Q + P Sbjct: 108 SIFIVRSEVEGVCRWLEDEAQAFYQRNNLKRKPAF 142 >gi|1360139 [98..407] 7-bladed beta-propeller Length = 310 Score = 26.9 bits (59), Expect = 2.6 Identities = 18/173 (10%), Positives = 37/173 (20%), Gaps = 20/173 (11%) Query: 1197 VHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFV-SLANGELVVYQREAGHFWDP-- 1253 ++ D M N V V S ++ + Sbjct: 60 AIIFNPKSGAWDNVPDM-NDKRWYPNNTTLANGDVLVLSGETDGEGLFNELP-QRYVAAT 117 Query: 1254 QNFKSVTLGTQGSPI--TKMVSVGGRLWC-GCQNRVLVLSPDTLQLEH-----MFYVGQD 1305 +++++T + P ++ +L+ G L PD F Sbjct: 118 NSWQNLTTAQRKIPYYPHMFLAPNNKLFFSGPWRSSQWLDPDGTGTWFEAPYSHFGGR-- 175 Query: 1306 SSRCVACMVDSSLGVWVTLKG---SAHVCLYHPDTFEQLAEVDVTPPVHRMLA 1355 S D + + + + A R Sbjct: 176 -SYGGHVYFDGKVLPVGGGNPPTETVELIDLNLPL-PTWAYQTPMSVARRQHN 226 >gi|1568595 [1..151] Ribosomal protein L9 Length = 151 Score = 26.5 bits (58), Expect = 3.1 Identities = 12/61 (19%), Positives = 24/61 (38%), Gaps = 5/61 (8%) Query: 348 RNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQ-----DQTGSLSRARPSSR 402 RNF L LA + S ++ + R AR + + ++ + G ++ +S Sbjct: 27 RNFLLPRGLAIVASRGAQKQADEIRRARETKSVRDLEHANEIKAAIEALGPIALPVKTSA 86 Query: 403 H 403 Sbjct: 87 D 87 Score = 25.3 bits (55), Expect = 6.6 Identities = 14/85 (16%), Positives = 27/85 (31%), Gaps = 5/85 (5%) Query: 687 AQRNIKQVAERIN-KGVRSAEEAERHARVLQE---IEAHIEGMEDLQAPLRRFLRQEMVI 742 AQ+ ++ K VR E A ++ I ++ D ++V Sbjct: 43 AQKQADEIRRARETKSVRDLEHANEIKAAIEALGPIALPVKTSADSGKLFGSVTAADVVA 102 Query: 743 EVKAIGGKK-DRSLFLFTDLIVCTT 766 +K GG D+ + + Sbjct: 103 AIKKAGGPNLDKRIVRLPKTHIKAV 127 >gi|2117634 [147..843] Lipoxigenase, C-terminal domain Length = 697 Score = 26.0 bits (57), Expect = 4.0 Identities = 11/46 (23%), Positives = 16/46 (33%), Gaps = 4/46 (8%) Query: 1015 PPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGP-QPCLHISI 1059 P R+ PEP PE + ++ Q L IS+ Sbjct: 586 PTLSRNF---MPEPGSPEYEELKTNPDKVFLKTITPQLQTLLGISL 628 >gi|125988 [12..184] EF Hand-like Length = 173 Score = 25.9 bits (56), Expect = 4.9 Identities = 17/118 (14%), Positives = 33/118 (27%), Gaps = 5/118 (4%) Query: 715 LQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFL--FTDLIVCTTLKRKSG 772 + I I + L A RQE + +G + + + LK K+ Sbjct: 24 YELIAVRIAKIAKLSAEKAEETRQEFLRVADQLGLAPGVRISVEEAAVNATDSLLKMKAE 83 Query: 773 SLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDED 830 + + IDT + E ++ + + LD + Sbjct: 84 EKAMAVIQSLIMYDCIDTDKDGYVSLP---EFKAFLQAVGPDITDDKAITCFNTLDFN 138 >gi|2811252 [82..382] Periplasmic binding protein-like II Length = 301 Score = 25.3 bits (55), Expect = 6.2 Identities = 7/60 (11%), Positives = 15/60 (24%), Gaps = 7/60 (11%) Query: 765 TTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAI 824 +K K G + + P ++ + + NR I + Sbjct: 188 DPVKDKPGFSYTNYYRHGGGTIALHCNFG-------PTSLTEVRQAFAYVLNRPKIVELF 240 >gi|153548 [125..455] beta-Lactamase/D-ala carboxypeptidase Length = 331 Score = 25.7 bits (56), Expect = 6.4 Identities = 12/69 (17%), Positives = 26/69 (37%), Gaps = 5/69 (7%) Query: 1125 ETTSSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAY 1184 +T + G P++ + +AL SS+ + L + + Y Sbjct: 88 QTLPDQSIVFQGSAPINSWYPAFSRPTPITGV-QALEYSSNAYMVQ----TALGLMGQTY 142 Query: 1185 QSSVWLGTE 1193 Q ++++GT Sbjct: 143 QPNMFVGTS 151 >gi|2497466 [46..370] Purine nucleoside hydrolase Length = 325 Score = 25.3 bits (55), Expect = 7.8 Identities = 6/65 (9%), Positives = 17/65 (25%), Gaps = 4/65 (6%) Query: 1293 TLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKG--SAHVCLYHPDTFEQLAEVDVTPPV 1350 L E ++ D++ + D + + H + E + + Sbjct: 162 NLSAEFNVWIDPDAANYIFR--DPDVKDKCIVVPLNLTHKAIATYKVNEMIYNEKNNSKL 219 Query: 1351 HRMLA 1355 + Sbjct: 220 RELFL 224 >gi|2463100 [37..265] Trypsin-like serine proteases Length = 229 Score = 25.1 bits (54), Expect = 7.9 Identities = 18/149 (12%), Positives = 28/149 (18%), Gaps = 34/149 (22%) Query: 1265 GSPITK------MVSV--GGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDS 1316 G P+T M +V R C V + Sbjct: 7 GKPLTSIVKYPFMATVWQNDRKLCTA-----------------SIVSPNYILSAGHCFVK 49 Query: 1317 SLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSD-AIIRQHKAACLRITALL 1375 + Q +V+ + G D AI++ + A Sbjct: 50 MSEENYIILVGTV-NAKLEKGNGQQFKVEKAHVYSETVFGQDIAIVKLKNSIDFSDNATQ 108 Query: 1376 VC----EELLWVGTS---AGVVLTMPTSP 1397 AG S Sbjct: 109 PITLSRRSNFTKTDLAFIAGWGRITDWSS 137 >gi|1938424 [576..818] Acyl-CoA dehydrogenase (flavoprotein), N-terminal and middle domains Length = 243 Score = 25.2 bits (55), Expect = 8.2 Identities = 4/32 (12%), Positives = 9/32 (27%) Query: 1371 ITALLVCEELLWVGTSAGVVLTMPTSPGTVSC 1402 + +CE + + V G + Sbjct: 74 VEYAHICELMGRSIFAPEVFNCQAPDTGNMEV 105 >gi|478310 [306..563] beta/alpha (TIM)-barrel Length = 258 Score = 24.9 bits (54), Expect = 8.6 Identities = 9/51 (17%), Positives = 14/51 (26%), Gaps = 3/51 (5%) Query: 1232 FVSLANGELVVYQREAGHF---WDPQNFKSVTLGTQGSPITKMVSVGGRLW 1279 F V + FK+ Q + ++SVGG Sbjct: 8 FADATTTPGAVTFNLDSAGLGGYTVDQFKADVRAKQAAGKKVIISVGGEKG 58 >gi|1420859 [36..611] Periplasmic binding protein-like II Length = 576 Score = 24.9 bits (54), Expect = 9.0 Identities = 6/26 (23%), Positives = 10/26 (38%) Query: 799 KLPLEDADIIKGASQATNRENIQKAI 824 K L + D + A +R + Q Sbjct: 294 KKALNNKDFRQAIQFAFDRASFQAQT 319 >gi|68234 [34..414] Citrate synthase Length = 381 Score = 24.8 bits (54), Expect = 9.4 Identities = 5/24 (20%), Positives = 11/24 (45%) Query: 661 PRYELLVKDLLKHTPEDHPDHPLL 684 PR +++ + + E + P L Sbjct: 281 PRAKVMKQTCDEVLQELGINDPQL 304 >gi|544020 [86..429] Nitrogenase iron-molybdenum protein, alpha and beta chains Length = 344 Score = 24.8 bits (54), Expect = 9.7 Identities = 12/69 (17%), Positives = 23/69 (32%), Gaps = 2/69 (2%) Query: 682 PLLLEAQRNIKQVAERINKGVRSAEEAER--HARVLQEIEAHIEGMEDLQAPLRRFLRQE 739 + + + + + + V A R + L E + G A + + +E Sbjct: 183 HISSSKEVDYEPYIDGQTRFVSQAAWFSRSIDCQNLTGKETVVFGDATHAASITKIPARE 242 Query: 740 MVIEVKAIG 748 M I V G Sbjct: 243 MGIRVSYTG 251 Underlying Matrix: BLOSUM62 Number of sequences tested against query: 1187 Number of sequences better than 10.0: 43 Number of calls to ALIGN: 50 Length of query: 1510 Total length of test sequences: 256703 Effective length of test sequences: 202633.0 Effective search space size: 296812805.7 Initial X dropoff for ALIGN: 25.0 bits