Legend:
Sequences with E-value BETTER than threshold 456 e-127
427 e-118
426 e-118
425 e-118
424 e-117
424 e-117
421 e-117
421 e-116
414 e-114
389 e-107
385 e-106
384 e-105
380 e-104
369 e-101
369 e-101
359 4e-98
359 6e-98
356 6e-97
354 2e-96
354 2e-96
353 4e-96
352 6e-96
336 6e-91
335 8e-91
335 1e-90
334 1e-90
313 3e-84
313 4e-84
309 7e-83
307 2e-82
306 3e-82
300 3e-80
299 5e-80
288 1e-76
287 2e-76
277 3e-73
261 2e-68
246 7e-64
242 1e-62
233 4e-60
232 7e-60
227 2e-58
227 4e-58
223 4e-57
213 5e-54
141 3e-32
81 4e-14
Alignments
>ref|NP_055628.1| KIAA0806 gene product [Homo sapiens]
ref|XP_001307.1| KIAA0806 gene product [Homo sapiens]
dbj|BAA34526.1| (AB018349) KIAA0806 protein [Homo sapiens]
Length = 1065
Score = 456 bits (1161), Expect = e-127
Identities = 102/540 (18%), Positives = 168/540 (30%), Gaps = 39/540 (7%)
Query: 50 GVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSN 109
PA + S + E S R+ +
Sbjct: 140 LQFYPALESLDLSSNIISEIKTSSF--PRMQLKYLNLSNN-----------RITTLEAGC 186
Query: 110 ASGWVSSEAARFLTGHNWSASDAGRPACI--FPGPVSWRQVPAYNAGQDQGSKYSFYGGK 167
SS L + S + ++ QG
Sbjct: 187 FDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLD------- 239
Query: 168 VKDEYLRRSPICRSAAALHTDTSA---RSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLM 224
RS + A + E L +N +T + G GL +L++L +
Sbjct: 240 -----SLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYV 294
Query: 225 RAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGE 284
+ + A S L+ G S + G + G
Sbjct: 295 SQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGV 354
Query: 285 VEGLCTCLCTDLRNNIISTV---QPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLR 341
L DLRNN IS AF GL L +L L N+I +T + F GL L
Sbjct: 355 FRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEH 414
Query: 342 LNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAY 401
L+++ N S+Q F + LK + L T L CDCHL+WLL W + + Q S + CA+
Sbjct: 415 LDLNNNAIMSIQENAFSQ-THLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAH 473
Query: 402 PSALHAHALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIR 461
P L ++ ++ C+ L+ P + +G + C+A +
Sbjct: 474 PEWLAGQSILNVDLKDFVCDDFLK-PQIRTHPET-IIALRGMNVTLTCTAVSSSDSPMST 531
Query: 462 WYHNRAPVEGDEQAGILLAE-SLIHDCTFITSELTLSHIGVWASGEWECTVSMAQG-NAS 519
+ + + D + + TS L L ++ G+++C V+ G N S
Sbjct: 532 VWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYS 591
Query: 520 KKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTR 579
+K ++ V E + + G A + + A R
Sbjct: 592 QKAKLTVNEMPSFLKTPMDLTIRTG-AMARLECAAEGHPAPQISWQKDGGTDFPAARERR 650
Score = 83.7 bits (205), Expect = 6e-15
Identities = 27/192 (14%), Positives = 56/192 (29%), Gaps = 19/192 (9%)
Query: 166 GKVKDEYLRRSPICRSAAA-----LHTDTSARSWSEFRLLSNNKIT----GLRNGSFLGL 216
C + S+N+++ L + +
Sbjct: 43 CPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQT---- 98
Query: 217 SLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMP 276
L+++ M + E + + Q Q + +
Sbjct: 99 --LQEVKMNYNELTEIPYFG-EPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNI 155
Query: 277 SRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGL-GELKRLDLSNNRIGCLTSETFQG 335
++ + +L NN I+T++ G F L L + L+ NR+ + + F+
Sbjct: 156 ISEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK- 213
Query: 336 LPRLLRLNISGN 347
LP L L + N
Sbjct: 214 LPHLQFLELKRN 225
Score = 67.8 bits (164), Expect = 4e-10
Identities = 24/144 (16%), Positives = 41/144 (27%), Gaps = 9/144 (6%)
Query: 428 THHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDC 487
L + + G +C+A +I W + A + D
Sbjct: 602 PSFLKTPMDLTIRTGAMARLECAAE-GHPAPQISWQKDGGT--DFPAARERRMHVMPEDD 658
Query: 488 TFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFR 547
F + ++ + G + C G S + VLET + P E RG+
Sbjct: 659 VFFIA-----NVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGET- 712
Query: 548 WPRTLAGITAYQSCLQYPFTSVPL 571
+ L + PL
Sbjct: 713 AVLQCIAGGSPAPRLNWTKDDGPL 736
Score = 36.6 bits (84), Expect = 0.89
Identities = 16/103 (15%), Positives = 33/103 (31%), Gaps = 11/103 (10%)
Query: 428 THHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDC 487
+ P + V +G+ QC A R+ W + P+ E
Sbjct: 696 PSFIRPLEDKTVTRGETAVLQCIAG-GSPAPRLNWTKDDGPLLVTE------RHFFAAAN 748
Query: 488 TFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETS 530
+ G+ +G++ C +S G + + V+ +
Sbjct: 749 QLLIIVDA----GLEDAGKYTCIMSNTLGTERGHIYLNVISSP 787
>ref|XP_003557.1| slit (Drosophila) homolog 2 [Homo sapiens]
Length = 1097
Score = 427 bits (1088), Expect = e-118
Identities = 72/495 (14%), Positives = 130/495 (25%), Gaps = 89/495 (17%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 126 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA 185
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 186 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 241
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C Y + + G ++ K + C + ++
Sbjct: 242 CSAKEQYFIPGTEDYRS-KLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA 300
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + E+ A + L + L
Sbjct: 301 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 360
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G S + + GL + L +N I+TV PGAF L L
Sbjct: 361 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 420
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 421 STLNLLAN------------------------------------------------PFNC 432
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHH-LIPS 434
+C+L WL W + + + ++ + C P L + + C+ + ++ L
Sbjct: 433 NCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRC 491
Query: 435 LRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQAGILLAESLIHD 486
+ + Y + + L L ++
Sbjct: 492 PTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNN 551
Query: 487 CTFITSELTLSHIGV 501
S + S++
Sbjct: 552 RISTLSNQSFSNMTQ 566
Score = 312 bits (792), Expect = 7e-84
Identities = 57/312 (18%), Positives = 92/312 (29%), Gaps = 31/312 (9%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 126 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA 185
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 186 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 241
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C Y + + G ++ K + C + ++
Sbjct: 242 CSAKEQYFIPGTEDYRS-KLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA 300
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + E+ A + L + L
Sbjct: 301 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 360
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G S + + GL + L +N I+TV PGAF L L
Sbjct: 361 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 420
Query: 316 KRLDLSNNRIGC 327
L+L N C
Sbjct: 421 STLNLLANPFNC 432
Score = 235 bits (594), Expect = 2e-60
Identities = 46/267 (17%), Positives = 93/267 (34%), Gaps = 11/267 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 301 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 360
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
VQ F GL LK L L +NRI C+ +++F GL + L++ N +++ PG FD L +L
Sbjct: 361 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 420
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+C+L WL W + + + ++ + C P L + + C+
Sbjct: 421 STLNLLANPFNCNCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG 479
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQ 474
+ ++ L + + Y + +
Sbjct: 480 NDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN 539
Query: 475 AGILLAESLIHDCTFITSELTLSHIGV 501
L L ++ S + S++
Sbjct: 540 YKHLTLIDLSNNRISTLSNQSFSNMTQ 566
Score = 233 bits (589), Expect = 6e-60
Identities = 46/266 (17%), Positives = 93/266 (34%), Gaps = 11/266 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 301 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 360
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
VQ F GL LK L L +NRI C+ +++F GL + L++ N +++ PG FD L +L
Sbjct: 361 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 420
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+C+L WL W + + + ++ + C P L + + C+
Sbjct: 421 STLNLLANPFNCNCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG 479
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQ 474
+ ++ L + + Y + +
Sbjct: 480 NDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN 539
Query: 475 AGILLAESLIHDCTFITSELTLSHIG 500
L L ++ S + S++
Sbjct: 540 YKHLTLIDLSNNRISTLSNQSFSNMT 565
Score = 212 bits (535), Expect = 1e-53
Identities = 51/404 (12%), Positives = 88/404 (21%), Gaps = 86/404 (21%)
Query: 119 ARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPI 178
L GHN + C S
Sbjct: 3 PSHLRGHNVAEVQKREFVCSGHQ-------------SFMAPSCSVLHCPAACTCSNNIVD 49
Query: 179 CRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACP 238
CR T+ L N I + G+F L ++ + + E A
Sbjct: 50 CRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQ 109
Query: 239 SPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRN 298
+ ++ +G S Q L+ + L L +
Sbjct: 110 GLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYD 169
Query: 299 NIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFD 358
N + T+ G F L ++ + L+ N
Sbjct: 170 NKLQTIAKGTFSPLRAIQTMHLAQN----------------------------------- 194
Query: 359 ELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQL 418
CDCHL+WL + ++ S C P L +G ++ +
Sbjct: 195 -------------PFICDCHLKWLADYLHTNPIETSG-ARCTSPRRLANKRIGQIKSKKF 240
Query: 419 CCE--------GALELHTHHLI------PSLRQVVFQGDRLPFQ----CSASYLGNDTRI 460
C G + + + +G +
Sbjct: 241 RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA 300
Query: 461 RWYHNRAPVEGDEQAGI------LLAESLIHDCTFITSELTLSH 498
N E GI L + ++ E
Sbjct: 301 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG 344
Score = 172 bits (432), Expect = 1e-41
Identities = 38/268 (14%), Positives = 63/268 (23%), Gaps = 26/268 (9%)
Query: 41 GERPKGLSGGVPGPAR-RRVVCSGGD----LPEPPEPGLLPNGTVTLGNRFSTAPCPQSG 95
+ KGL R R+ C G D L L N T+ S
Sbjct: 363 HKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLST 422
Query: 96 LAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPA----- 150
L + P + W+ +L G P C P +++P
Sbjct: 423 L--NLLANPFNCNCYLAWLGE----WLRKKRIV---TGNPRC--QKPYFLKEIPIQDVAI 471
Query: 151 ----YNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKIT 206
+ G D S + L C + L N+ T
Sbjct: 472 QDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFT 531
Query: 207 GLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSS 266
+ L + + + + + L + S L + G S
Sbjct: 532 LVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKS 590
Query: 267 SQEAASGLMPSRRLQRGEVEGLCTCLCT 294
+ + + G L
Sbjct: 591 LRLLSLHGNDISVVPEGAFNDLSALSHL 618
Score = 142 bits (356), Expect = 1e-32
Identities = 49/192 (25%), Positives = 81/192 (41%), Gaps = 9/192 (4%)
Query: 270 AASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLT 329
+ E+ DL NN IST+ +F + +L L LS NR+ C+
Sbjct: 523 LYLDGNQFTLVP-KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 581
Query: 330 SETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNR 389
TF GL L L++ GN S + G F++L AL + +G L CDC+++WL W ++
Sbjct: 582 PRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE 641
Query: 390 SLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALEL------HTHHLIPSLRQVVFQGD 443
+ CA P + L + + C+G +++ + P D
Sbjct: 642 YKEPG-IARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSD 700
Query: 444 RLPF-QCSASYL 454
+ F +C+ Y
Sbjct: 701 PVDFYRCTCPYG 712
Score = 123 bits (306), Expect = 9e-27
Identities = 11/116 (9%), Positives = 29/116 (24%), Gaps = 11/116 (9%)
Query: 400 AYPSALHAHALGSLQEAQLCCEG--ALELHTHHLIPSLRQVVFQGDRLPFQCS--ASYLG 455
PS L H + +Q+ + C G + + ++ + + +
Sbjct: 1 MGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPT 60
Query: 456 NDTR--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
N + ++ L L ++ + + S
Sbjct: 61 NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNS 116
Score = 119 bits (296), Expect = 1e-25
Identities = 38/220 (17%), Positives = 65/220 (29%), Gaps = 39/220 (17%)
Query: 245 WRLHSKCTLSMAGNQKNQGGSSSQEA---ASGLMPSRRLQRGEVEGLCTCLCTDLRNNII 301
++ + S+ + L + L L N +
Sbjct: 522 ELYLDGNQFTLVP----KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRL 577
Query: 302 STVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELP 361
+ P F GL L+ L L N I + F L L L I N
Sbjct: 578 RCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGAN-------------- 623
Query: 362 ALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCE 421
L CDC+++WL W ++ + CA P + L + + C+
Sbjct: 624 ----------PLYCDCNMQWLSDWVKSEYKEPG-IARCAGPGEMADKLLLTTPSKKFTCQ 672
Query: 422 GALEL------HTHHLIPSLRQVVFQGDRLPF-QCSASYL 454
G +++ + P D + F +C+ Y
Sbjct: 673 GPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYG 712
Score = 53.8 bits (128), Expect = 6e-06
Identities = 16/136 (11%), Positives = 32/136 (22%), Gaps = 12/136 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEP---GLLPNGTVTLGNRFSTAPCPQSGLAQS 99
P G+ G D+ PE L + +G C L+
Sbjct: 580 IPPRTFDGLKSLRLLS--LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDW 637
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQ---D 156
+ ++ A + + + + C P V+ +
Sbjct: 638 VKSEYKEPGIA----RCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKN 693
Query: 157 QGSKYSFYGGKVKDEY 172
G+ S +
Sbjct: 694 DGTCNSDPVDFYRCTC 709
>gb|AAD44759.1|AF144628_1 (AF144628) SLIT2 [Mus musculus]
Length = 1521
Score = 426 bits (1086), Expect = e-118
Identities = 72/495 (14%), Positives = 128/495 (25%), Gaps = 97/495 (19%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 362 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTVAKGTFSALRA 421
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 422 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 477
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G ++ K + C + ++
Sbjct: 478 CSGTEDYRSKL---------SGDCFADLACPEKCRCEGTTVDCSNQRLNKIPDHIPQYTA 528
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + E+ A + L + L
Sbjct: 529 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 588
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G S + + GL + L +N I+TV PGAF L L
Sbjct: 589 VQHKMFKGLESLKTLMLRSNRISCVGNDSFIGLGSVRLLSLYDNQITTVAPGAFDSLHSL 648
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 649 STLNLLAN------------------------------------------------PFNC 660
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHH-LIPS 434
+CHL WL W + + + ++ + C P L + + C+ + ++ L
Sbjct: 661 NCHLAWLGEWLRRKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRC 719
Query: 435 LRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQAGILLAESLIHD 486
+ + Y + + L L ++
Sbjct: 720 PSECTCLDTVVRCSNKGLKVLPKGIPKDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNN 779
Query: 487 CTFITSELTLSHIGV 501
S + S++
Sbjct: 780 RISTLSNQSFSNMTQ 794
Score = 370 bits (941), Expect = e-101
Identities = 60/354 (16%), Positives = 108/354 (29%), Gaps = 36/354 (10%)
Query: 162 SFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEK 221
+ + + C A + +E L+ N IT + F GL L
Sbjct: 24 APQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRV 83
Query: 222 LLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQ 281
L + + E+ A ++ L + G + + +
Sbjct: 84 LQLMENRISTIERGAFQDLKELERLRLNRNNLQLFPELLFLGTAKLYRLDLSENQIQAIP 143
Query: 282 RGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLR 341
R G L N IS ++ GAF L +L+ L L+NN I L+ +F +P+L
Sbjct: 144 RKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKL-- 201
Query: 342 LNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAY 401
+ L + L CDCHL WL W + R ++ +T C
Sbjct: 202 ----------------------RTFRLHSNNLYCDCHLAWLSDWLRQRP-RVGLYTQCMG 238
Query: 402 PSALHAHALGSLQEAQLCCEG--ALELHTHHLIPSLRQVVFQGDRLPFQCS--ASYLGND 457
PS L H + +Q+ + C G + + ++ + + + N
Sbjct: 239 PSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNL 298
Query: 458 TR--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+ + L L ++ + + S
Sbjct: 299 PETITEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISELAPDAFQGLRSLNS 352
Score = 310 bits (787), Expect = 3e-83
Identities = 56/312 (17%), Positives = 90/312 (27%), Gaps = 39/312 (12%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 362 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTVAKGTFSALRA 421
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 422 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 477
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G ++ K + C + ++
Sbjct: 478 CSGTEDYRSKL---------SGDCFADLACPEKCRCEGTTVDCSNQRLNKIPDHIPQYTA 528
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + E+ A + L + L
Sbjct: 529 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 588
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G S + + GL + L +N I+TV PGAF L L
Sbjct: 589 VQHKMFKGLESLKTLMLRSNRISCVGNDSFIGLGSVRLLSLYDNQITTVAPGAFDSLHSL 648
Query: 316 KRLDLSNNRIGC 327
L+L N C
Sbjct: 649 STLNLLANPFNC 660
Score = 248 bits (628), Expect = 1e-64
Identities = 57/462 (12%), Positives = 101/462 (21%), Gaps = 85/462 (18%)
Query: 56 RRRVVCSGGDLPEPPEPGL-LPNGTVTLGNRFST--APCPQSGLAQSFRLCPEQYSNASG 112
+ + ++ T + C + L+ R P
Sbjct: 177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPR----VGL 232
Query: 113 WVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEY 172
+ L GHN + C S
Sbjct: 233 YTQCMGPSHLRGHNVAEVQKREFVCSGHQ-------------SFMAPSCSVLHCPAACTC 279
Query: 173 LRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDED 232
CR T+ L N I + G+F L +L + + E
Sbjct: 280 SNNIVDCRGKGLTEIPTNLPETITEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISEL 339
Query: 233 EKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCL 292
A + ++ +G S Q L+ + L
Sbjct: 340 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLN 399
Query: 293 CTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSL 352
L +N + TV TF L + ++++ N
Sbjct: 400 LLSLYDNKLQTV------------------------AKGTFSALRAIQTMHLAQN----- 430
Query: 353 QPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGS 412
CDCHL+WL + ++ S C P L +G
Sbjct: 431 -------------------PFICDCHLKWLADYLHTNPIETSG-ARCTSPRRLANKRIGQ 470
Query: 413 LQEAQLCCEGALELHTHHLI------PSLRQVVFQGDRLPFQ----CSASYLGNDTRIRW 462
++ + C G + + + +G +
Sbjct: 471 IKSKKFRCSGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQRLNKIPDHIPQYTAEL 530
Query: 463 YHNRAPVEGDEQAGI------LLAESLIHDCTFITSELTLSH 498
N E GI L + ++ E
Sbjct: 531 RLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG 572
Score = 236 bits (596), Expect = 9e-61
Identities = 47/267 (17%), Positives = 93/267 (34%), Gaps = 11/267 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 529 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 588
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
VQ F GL LK L L +NRI C+ +++F GL + L++ N +++ PG FD L +L
Sbjct: 589 VQHKMFKGLESLKTLMLRSNRISCVGNDSFIGLGSVRLLSLYDNQITTVAPGAFDSLHSL 648
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+CHL WL W + + + ++ + C P L + + C+
Sbjct: 649 STLNLLANPFNCNCHLAWLGEWLRRKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG 707
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQ 474
+ ++ L + + Y + +
Sbjct: 708 NDDNSCSPLSRCPSECTCLDTVVRCSNKGLKVLPKGIPKDVTELYLDGNQFTLVPKELSN 767
Query: 475 AGILLAESLIHDCTFITSELTLSHIGV 501
L L ++ S + S++
Sbjct: 768 YKHLTLIDLSNNRISTLSNQSFSNMTQ 794
Score = 234 bits (591), Expect = 3e-60
Identities = 47/266 (17%), Positives = 93/266 (34%), Gaps = 11/266 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 529 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 588
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
VQ F GL LK L L +NRI C+ +++F GL + L++ N +++ PG FD L +L
Sbjct: 589 VQHKMFKGLESLKTLMLRSNRISCVGNDSFIGLGSVRLLSLYDNQITTVAPGAFDSLHSL 648
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+CHL WL W + + + ++ + C P L + + C+
Sbjct: 649 STLNLLANPFNCNCHLAWLGEWLRRKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG 707
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQ 474
+ ++ L + + Y + +
Sbjct: 708 NDDNSCSPLSRCPSECTCLDTVVRCSNKGLKVLPKGIPKDVTELYLDGNQFTLVPKELSN 767
Query: 475 AGILLAESLIHDCTFITSELTLSHIG 500
L L ++ S + S++
Sbjct: 768 YKHLTLIDLSNNRISTLSNQSFSNMT 793
Score = 221 bits (558), Expect = 2e-56
Identities = 62/531 (11%), Positives = 114/531 (20%), Gaps = 127/531 (23%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPE-----------PGLLPNGTVTLGNRFSTAPC 91
+G + R R+ +L PE L N + +
Sbjct: 94 IERGAFQDLKELERLRLN--RNNLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAV 151
Query: 92 PQSGLA-QSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRP--------------- 135
L ++ + A + L +N +
Sbjct: 152 DIKNLQLDYNQISCIED-GAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNN 210
Query: 136 ------------------------ACIFPGPVS------WRQVPAYNAGQ--DQGSKYSF 163
C+ P + ++ +G S
Sbjct: 211 LYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSV 270
Query: 164 YGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLL 223
CR T+ L N I + G+F L +L
Sbjct: 271 LHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNSIRVIPPGAFSPYKKLRRLD 330
Query: 224 MRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRG 283
+ + E A + ++ +G S Q L+
Sbjct: 331 LSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 390
Query: 284 EVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLN 343
+ L L +N + TV TF L + ++
Sbjct: 391 AFQDLHNLNLLSLYDNKLQTV------------------------AKGTFSALRAIQTMH 426
Query: 344 ISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPS 403
++ N CDCHL+WL + ++ S C P
Sbjct: 427 LAQN------------------------PFICDCHLKWLADYLHTNPIETSG-ARCTSPR 461
Query: 404 ALHAHALGSLQEAQLCCEGALELHTHHLI------PSLRQVVFQGDRLPFQ----CSASY 453
L +G ++ + C G + + + +G +
Sbjct: 462 RLANKRIGQIKSKKFRCSGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQRLNKIPD 521
Query: 454 LGNDTRIRWYHNRAPVEGDEQAGI------LLAESLIHDCTFITSELTLSH 498
N E GI L + ++ E
Sbjct: 522 HIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG 572
Score = 169 bits (426), Expect = 6e-41
Identities = 38/268 (14%), Positives = 64/268 (23%), Gaps = 26/268 (9%)
Query: 41 GERPKGLSGGVPGPAR-RRVVCSGGD----LPEPPEPGLLPNGTVTLGNRFSTAPCPQSG 95
+ KGL R R+ C G D L L N T+ + S
Sbjct: 591 HKMFKGLESLKTLMLRSNRISCVGNDSFIGLGSVRLLSLYDNQITTVAPGAFDSLHSLST 650
Query: 96 LAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPA----- 150
L + P + W+ +L G P C P +++P
Sbjct: 651 L--NLLANPFNCNCHLAWLGE----WLRRKRIV---TGNPRC--QKPYFLKEIPIQDVAI 699
Query: 151 ----YNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKIT 206
+ G D S + L C + L N+ T
Sbjct: 700 QDFTCDDGNDDNSCSPLSRCPSECTCLDTVVRCSNKGLKVLPKGIPKDVTELYLDGNQFT 759
Query: 207 GLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSS 266
+ L + + + + + L + S L + G S
Sbjct: 760 LVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKS 818
Query: 267 SQEAASGLMPSRRLQRGEVEGLCTCLCT 294
+ + + G L
Sbjct: 819 LRLLSLHGNDISVVPEGAFNDLSALSHL 846
Score = 142 bits (355), Expect = 1e-32
Identities = 49/192 (25%), Positives = 81/192 (41%), Gaps = 9/192 (4%)
Query: 270 AASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLT 329
+ E+ DL NN IST+ +F + +L L LS NR+ C+
Sbjct: 751 LYLDGNQFTLVP-KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 809
Query: 330 SETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNR 389
TF GL L L++ GN S + G F++L AL + +G L CDC+++WL W ++
Sbjct: 810 PRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE 869
Query: 390 SLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALEL------HTHHLIPSLRQVVFQGD 443
+ CA P + L + + C+G +++ + P D
Sbjct: 870 YKEPG-IARCAGPGEMADKLLLTTPSKKFTCQGPVDITIQAKCNPCLSNPCKNDGTCNND 928
Query: 444 RLPF-QCSASYL 454
+ F +C+ Y
Sbjct: 929 PVDFYRCTCPYG 940
Score = 51.8 bits (123), Expect = 2e-05
Identities = 40/229 (17%), Positives = 64/229 (27%), Gaps = 35/229 (15%)
Query: 8 LLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLP 67
L L L+ +L +AP+A CP C CS G + G A R V ++P
Sbjct: 11 LSLGLVLSILNKVAPQA-----CP---AQCSCS-----GSTVDCHGLALRSV---PRNIP 54
Query: 68 -EPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHN 126
L N + L A + L +N
Sbjct: 55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENRISTIERGAFQDLKELERLRLNRNN 114
Query: 127 WSASDAGRP---ACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAA 183
A ++ +S Q+ A +G+ ++
Sbjct: 115 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDI------------KNLQLDYNQ 162
Query: 184 ALHTDTS---ARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFS 229
+ A E L+NN IT L SF + L + ++
Sbjct: 163 ISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Score = 49.9 bits (118), Expect = 9e-05
Identities = 14/136 (10%), Positives = 33/136 (23%), Gaps = 12/136 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEP---GLLPNGTVTLGNRFSTAPCPQSGLAQS 99
P G+ G D+ PE L + +G C L+
Sbjct: 808 IPPRTFDGLKSLRLLS--LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDW 865
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQ---D 156
+ ++ A + + + + C P ++ + +
Sbjct: 866 VKSEYKEPGIA----RCAGPGEMADKLLLTTPSKKFTCQGPVDITIQAKCNPCLSNPCKN 921
Query: 157 QGSKYSFYGGKVKDEY 172
G+ + +
Sbjct: 922 DGTCNNDPVDFYRCTC 937
>gb|AAD25539.1|AF133270_1 (AF133270) SLIT2 [Homo sapiens]
Length = 1525
Score = 425 bits (1082), Expect = e-118
Identities = 71/495 (14%), Positives = 128/495 (25%), Gaps = 97/495 (19%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 366 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA 425
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 426 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 481
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G ++ K + C + ++
Sbjct: 482 CSGTEDYRSKL---------SGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA 532
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + E+ A + L + L
Sbjct: 533 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 592
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G S + + GL + L +N I+TV PGAF L L
Sbjct: 593 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 652
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 653 STLNLLAN------------------------------------------------PFNC 664
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHH-LIPS 434
+C+L WL W + + + ++ + C P L + + C+ + ++ L
Sbjct: 665 NCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRC 723
Query: 435 LRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQAGILLAESLIHD 486
+ + Y + + L L ++
Sbjct: 724 PTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNN 783
Query: 487 CTFITSELTLSHIGV 501
S + S++
Sbjct: 784 RISTLSNQSFSNMTQ 798
Score = 373 bits (949), Expect = e-102
Identities = 62/358 (17%), Positives = 108/358 (29%), Gaps = 40/358 (11%)
Query: 162 SFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEK 221
+ + + C A + +E L+ N IT + F GL L
Sbjct: 24 APQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRV 83
Query: 222 LLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQ 281
L + + E+ A ++ L + G + + +
Sbjct: 84 LQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIP 143
Query: 282 RGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLR 341
R G L N IS ++ GAF L +L+ L L+NN I L+ +F +P+L
Sbjct: 144 RKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKL-- 201
Query: 342 LNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAY 401
+ L + L CDCHL WL W + R ++ +T C
Sbjct: 202 ----------------------RTFRLHSNNLYCDCHLAWLSDWLRKRP-RVGLYTQCMG 238
Query: 402 PSALHAHALGSLQEAQLCCEGALELHTHHLIP------SLRQVVFQGDRLPFQCS--ASY 453
PS L H + +Q+ + C E H + P + + +
Sbjct: 239 PSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEI 298
Query: 454 LGNDTR--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
N + ++ L L ++ + + S
Sbjct: 299 PTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNS 356
Score = 311 bits (789), Expect = 2e-83
Identities = 56/312 (17%), Positives = 90/312 (27%), Gaps = 39/312 (12%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 366 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA 425
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 426 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 481
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G ++ K + C + ++
Sbjct: 482 CSGTEDYRSKL---------SGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA 532
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + E+ A + L + L
Sbjct: 533 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 592
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G S + + GL + L +N I+TV PGAF L L
Sbjct: 593 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 652
Query: 316 KRLDLSNNRIGC 327
L+L N C
Sbjct: 653 STLNLLANPFNC 664
Score = 247 bits (626), Expect = 2e-64
Identities = 56/462 (12%), Positives = 102/462 (21%), Gaps = 81/462 (17%)
Query: 56 RRRVVCSGGDLPEPPEPGL-LPNGTVTLGNRFST--APCPQSGLAQSFRLCPEQYSNASG 112
+ + ++ T + C + L+ R P
Sbjct: 177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRKRPR----VGL 232
Query: 113 WVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEY 172
+ L GHN + C + S
Sbjct: 233 YTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSC---------SVLHCPAACTC 283
Query: 173 LRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDED 232
CR T+ L N I + G+F L ++ + + E
Sbjct: 284 SNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISEL 343
Query: 233 EKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCL 292
A + ++ +G S Q L+ + L
Sbjct: 344 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLN 403
Query: 293 CTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSL 352
L +N + T+ G F L ++ + L+ N
Sbjct: 404 LLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN----------------------------- 434
Query: 353 QPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGS 412
CDCHL+WL + ++ S C P L +G
Sbjct: 435 -------------------PFICDCHLKWLADYLHTNPIETSG-ARCTSPRRLANKRIGQ 474
Query: 413 LQEAQLCCEGALELHTHHLI------PSLRQVVFQGDRLPFQ----CSASYLGNDTRIRW 462
++ + C G + + + +G +
Sbjct: 475 IKSKKFRCSGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAEL 534
Query: 463 YHNRAPVEGDEQAGI------LLAESLIHDCTFITSELTLSH 498
N E GI L + ++ E
Sbjct: 535 RLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG 576
Score = 233 bits (589), Expect = 5e-60
Identities = 46/267 (17%), Positives = 93/267 (34%), Gaps = 11/267 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 533 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 592
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
VQ F GL LK L L +NRI C+ +++F GL + L++ N +++ PG FD L +L
Sbjct: 593 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 652
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+C+L WL W + + + ++ + C P L + + C+
Sbjct: 653 STLNLLANPFNCNCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG 711
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQ 474
+ ++ L + + Y + +
Sbjct: 712 NDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN 771
Query: 475 AGILLAESLIHDCTFITSELTLSHIGV 501
L L ++ S + S++
Sbjct: 772 YKHLTLIDLSNNRISTLSNQSFSNMTQ 798
Score = 231 bits (584), Expect = 2e-59
Identities = 46/266 (17%), Positives = 93/266 (34%), Gaps = 11/266 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 533 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 592
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
VQ F GL LK L L +NRI C+ +++F GL + L++ N +++ PG FD L +L
Sbjct: 593 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 652
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+C+L WL W + + + ++ + C P L + + C+
Sbjct: 653 STLNLLANPFNCNCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG 711
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQ 474
+ ++ L + + Y + +
Sbjct: 712 NDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN 771
Query: 475 AGILLAESLIHDCTFITSELTLSHIG 500
L L ++ S + S++
Sbjct: 772 YKHLTLIDLSNNRISTLSNQSFSNMT 797
Score = 195 bits (491), Expect = 2e-48
Identities = 49/270 (18%), Positives = 84/270 (30%), Gaps = 17/270 (6%)
Query: 245 WRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTV 304
+ T+ + + L +GL + L N I+ +
Sbjct: 308 EIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITEL 367
Query: 305 QPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALK 364
F GL L+ L L+ N+I CL + FQ L L L++ N ++ G F L A++
Sbjct: 368 PKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQ 427
Query: 365 VVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGAL 424
+ L CDCHL+WL + ++ S C P L +G ++ + C G
Sbjct: 428 TMHLAQNPFICDCHLKWLADYLHTNPIETSG-ARCTSPRRLANKRIGQIKSKKFRCSGTE 486
Query: 425 ELHTHHLI------PSLRQVVFQGDRLPFQ----CSASYLGNDTRIRWYHNRAPVEGDEQ 474
+ + + +G + N E
Sbjct: 487 DYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEA 546
Query: 475 AGI------LLAESLIHDCTFITSELTLSH 498
GI L + ++ E
Sbjct: 547 TGIFKKLPQLRKINFSNNKITDIEEGAFEG 576
Score = 170 bits (428), Expect = 3e-41
Identities = 38/268 (14%), Positives = 63/268 (23%), Gaps = 26/268 (9%)
Query: 41 GERPKGLSGGVPGPAR-RRVVCSGGD----LPEPPEPGLLPNGTVTLGNRFSTAPCPQSG 95
+ KGL R R+ C G D L L N T+ S
Sbjct: 595 HKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLST 654
Query: 96 LAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPA----- 150
L + P + W+ +L G P C P +++P
Sbjct: 655 L--NLLANPFNCNCYLAWLGE----WLRKKRIV---TGNPRC--QKPYFLKEIPIQDVAI 703
Query: 151 ----YNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKIT 206
+ G D S + L C + L N+ T
Sbjct: 704 QDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFT 763
Query: 207 GLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSS 266
+ L + + + + + L + S L + G S
Sbjct: 764 LVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKS 822
Query: 267 SQEAASGLMPSRRLQRGEVEGLCTCLCT 294
+ + + G L
Sbjct: 823 LRLLSLHGNDISVVPEGAFNDLSALSHL 850
Score = 141 bits (353), Expect = 2e-32
Identities = 49/192 (25%), Positives = 81/192 (41%), Gaps = 9/192 (4%)
Query: 270 AASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLT 329
+ E+ DL NN IST+ +F + +L L LS NR+ C+
Sbjct: 755 LYLDGNQFTLVP-KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 813
Query: 330 SETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNR 389
TF GL L L++ GN S + G F++L AL + +G L CDC+++WL W ++
Sbjct: 814 PRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE 873
Query: 390 SLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALEL------HTHHLIPSLRQVVFQGD 443
+ CA P + L + + C+G +++ + P D
Sbjct: 874 YKEPG-IARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSD 932
Query: 444 RLPF-QCSASYL 454
+ F +C+ Y
Sbjct: 933 PVDFYRCTCPYG 944
Score = 58.4 bits (140), Expect = 2e-07
Identities = 39/229 (17%), Positives = 64/229 (27%), Gaps = 35/229 (15%)
Query: 8 LLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLP 67
L L L+ +L +AP+A CP C CS G + G A R V ++P
Sbjct: 11 LSLGLVLAILNKVAPQA-----CP---AQCSCS-----GSTVDCHGLALRSV---PRNIP 54
Query: 68 -EPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHN 126
L N + L A + L ++
Sbjct: 55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNH 114
Query: 127 WSASDAGRP---ACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAA 183
A ++ +S Q+ A +G+ ++
Sbjct: 115 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDI------------KNLQLDYNQ 162
Query: 184 ALHTDTS---ARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFS 229
+ A E L+NN IT L SF + L + ++
Sbjct: 163 ISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Score = 53.4 bits (127), Expect = 8e-06
Identities = 16/136 (11%), Positives = 32/136 (22%), Gaps = 12/136 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEP---GLLPNGTVTLGNRFSTAPCPQSGLAQS 99
P G+ G D+ PE L + +G C L+
Sbjct: 812 IPPRTFDGLKSLRLLS--LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDW 869
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQ---D 156
+ ++ A + + + + C P V+ +
Sbjct: 870 VKSEYKEPGIA----RCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKN 925
Query: 157 QGSKYSFYGGKVKDEY 172
G+ S +
Sbjct: 926 DGTCNSDPVDFYRCTC 941
Score = 33.5 bits (76), Expect = 7.3
Identities = 12/105 (11%), Positives = 24/105 (22%), Gaps = 15/105 (14%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPE-----------PGLLPNGTVTLGNRFSTAPC 91
+G + R R+ + L PE L N + +
Sbjct: 94 IERGAFQDLKELERLRLNRNH--LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAV 151
Query: 92 PQSGLA-QSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRP 135
L ++ + A + L +N +
Sbjct: 152 DIKNLQLDYNQISCIED-GAFRALRDLEVLTLNNNNITRLSVASF 195
>ref|NP_004778.1| slit (Drosophila) homolog 2 [Homo sapiens]
dbj|BAA35185.1| (AB017168) Slit-2 protein [Homo sapiens]
Length = 1529
Score = 424 bits (1080), Expect = e-117
Identities = 72/495 (14%), Positives = 130/495 (25%), Gaps = 89/495 (17%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 362 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA 421
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 422 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 477
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C Y + + G ++ K + C + ++
Sbjct: 478 CSAKEQYFIPGTEDYRS-KLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA 536
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + E+ A + L + L
Sbjct: 537 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 596
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G S + + GL + L +N I+TV PGAF L L
Sbjct: 597 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 656
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 657 STLNLLAN------------------------------------------------PFNC 668
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHH-LIPS 434
+C+L WL W + + + ++ + C P L + + C+ + ++ L
Sbjct: 669 NCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRC 727
Query: 435 LRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQAGILLAESLIHD 486
+ + Y + + L L ++
Sbjct: 728 PTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNN 787
Query: 487 CTFITSELTLSHIGV 501
S + S++
Sbjct: 788 RISTLSNQSFSNMTQ 802
Score = 373 bits (949), Expect = e-102
Identities = 60/354 (16%), Positives = 109/354 (29%), Gaps = 36/354 (10%)
Query: 162 SFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEK 221
+ + + C A + +E L+ N IT + F GL L
Sbjct: 24 APQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRV 83
Query: 222 LLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQ 281
L + + E+ A ++ L + G + + +
Sbjct: 84 LQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIP 143
Query: 282 RGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLR 341
R G L N IS ++ GAF L +L+ L L+NN I L+ +F +P+L
Sbjct: 144 RKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKL-- 201
Query: 342 LNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAY 401
+ L + L CDCHL WL W + R ++ +T C
Sbjct: 202 ----------------------RTFRLHSNNLYCDCHLAWLSDWLRQRP-RVGLYTQCMG 238
Query: 402 PSALHAHALGSLQEAQLCCEG--ALELHTHHLIPSLRQVVFQGDRLPFQCS--ASYLGND 457
PS L H + +Q+ + C G + + ++ + + + N
Sbjct: 239 PSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNL 298
Query: 458 TR--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+ ++ L L ++ + + S
Sbjct: 299 PETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNS 352
Score = 310 bits (787), Expect = 3e-83
Identities = 57/312 (18%), Positives = 92/312 (29%), Gaps = 31/312 (9%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 362 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA 421
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 422 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 477
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C Y + + G ++ K + C + ++
Sbjct: 478 CSAKEQYFIPGTEDYRS-KLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA 536
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + E+ A + L + L
Sbjct: 537 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 596
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G S + + GL + L +N I+TV PGAF L L
Sbjct: 597 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 656
Query: 316 KRLDLSNNRIGC 327
L+L N C
Sbjct: 657 STLNLLANPFNC 668
Score = 239 bits (605), Expect = 8e-62
Identities = 56/470 (11%), Positives = 101/470 (20%), Gaps = 93/470 (19%)
Query: 56 RRRVVCSGGDLPEPPEPGL-LPNGTVTLGNRFST--APCPQSGLAQSFRLCPEQYSNASG 112
+ + ++ T + C + L+ R P
Sbjct: 177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPR----VGL 232
Query: 113 WVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEY 172
+ L GHN + C S
Sbjct: 233 YTQCMGPSHLRGHNVAEVQKREFVCSGHQ-------------SFMAPSCSVLHCPAACTC 279
Query: 173 LRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDED 232
CR T+ L N I + G+F L ++ + + E
Sbjct: 280 SNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISEL 339
Query: 233 EKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCL 292
A + ++ +G S Q L+ + L
Sbjct: 340 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLN 399
Query: 293 CTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSL 352
L +N + T+ G F L ++ + L+ N
Sbjct: 400 LLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN----------------------------- 430
Query: 353 QPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGS 412
CDCHL+WL + ++ S C P L +G
Sbjct: 431 -------------------PFICDCHLKWLADYLHTNPIETSG-ARCTSPRRLANKRIGQ 470
Query: 413 LQEAQLCCE--------GALELHTHHLI------PSLRQVVFQGDRLPFQ----CSASYL 454
++ + C G + + + +G +
Sbjct: 471 IKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEH 530
Query: 455 GNDTRIRWYHNRAPVEGDEQAGI------LLAESLIHDCTFITSELTLSH 498
N E GI L + ++ E
Sbjct: 531 IPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG 580
Score = 233 bits (590), Expect = 4e-60
Identities = 46/267 (17%), Positives = 93/267 (34%), Gaps = 11/267 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 537 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 596
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
VQ F GL LK L L +NRI C+ +++F GL + L++ N +++ PG FD L +L
Sbjct: 597 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 656
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+C+L WL W + + + ++ + C P L + + C+
Sbjct: 657 STLNLLANPFNCNCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG 715
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQ 474
+ ++ L + + Y + +
Sbjct: 716 NDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN 775
Query: 475 AGILLAESLIHDCTFITSELTLSHIGV 501
L L ++ S + S++
Sbjct: 776 YKHLTLIDLSNNRISTLSNQSFSNMTQ 802
Score = 231 bits (585), Expect = 2e-59
Identities = 46/266 (17%), Positives = 93/266 (34%), Gaps = 11/266 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 537 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 596
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
VQ F GL LK L L +NRI C+ +++F GL + L++ N +++ PG FD L +L
Sbjct: 597 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 656
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+C+L WL W + + + ++ + C P L + + C+
Sbjct: 657 STLNLLANPFNCNCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG 715
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQ 474
+ ++ L + + Y + +
Sbjct: 716 NDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN 775
Query: 475 AGILLAESLIHDCTFITSELTLSHIG 500
L L ++ S + S++
Sbjct: 776 YKHLTLIDLSNNRISTLSNQSFSNMT 801
Score = 209 bits (529), Expect = 6e-53
Identities = 61/539 (11%), Positives = 114/539 (20%), Gaps = 135/539 (25%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPE-----------PGLLPNGTVTLGNRFSTAPC 91
+G + R R+ + L PE L N + +
Sbjct: 94 IERGAFQDLKELERLRLNRNH--LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAV 151
Query: 92 PQSGLA-QSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRP--------------- 135
L ++ + A + L +N +
Sbjct: 152 DIKNLQLDYNQISCIED-GAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNN 210
Query: 136 ------------------------ACIFPGPVS------WRQVPAYNAGQ--DQGSKYSF 163
C+ P + ++ +G S
Sbjct: 211 LYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSV 270
Query: 164 YGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLL 223
CR T+ L N I + G+F L ++
Sbjct: 271 LHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRID 330
Query: 224 MRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRG 283
+ + E A + ++ +G S Q L+
Sbjct: 331 LSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 390
Query: 284 EVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLN 343
+ L L +N + T+ G F L ++ + L+ N
Sbjct: 391 AFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN-------------------- 430
Query: 344 ISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPS 403
CDCHL+WL + ++ S C P
Sbjct: 431 ----------------------------PFICDCHLKWLADYLHTNPIETSG-ARCTSPR 461
Query: 404 ALHAHALGSLQEAQLCCE--------GALELHTHHLI------PSLRQVVFQGDRLPFQ- 448
L +G ++ + C G + + + +G +
Sbjct: 462 RLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSN 521
Query: 449 ---CSASYLGNDTRIRWYHNRAPVEGDEQAGI------LLAESLIHDCTFITSELTLSH 498
N E GI L + ++ E
Sbjct: 522 QKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG 580
Score = 171 bits (429), Expect = 3e-41
Identities = 38/268 (14%), Positives = 63/268 (23%), Gaps = 26/268 (9%)
Query: 41 GERPKGLSGGVPGPAR-RRVVCSGGD----LPEPPEPGLLPNGTVTLGNRFSTAPCPQSG 95
+ KGL R R+ C G D L L N T+ S
Sbjct: 599 HKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLST 658
Query: 96 LAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPA----- 150
L + P + W+ +L G P C P +++P
Sbjct: 659 L--NLLANPFNCNCYLAWLGE----WLRKKRIV---TGNPRC--QKPYFLKEIPIQDVAI 707
Query: 151 ----YNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKIT 206
+ G D S + L C + L N+ T
Sbjct: 708 QDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFT 767
Query: 207 GLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSS 266
+ L + + + + + L + S L + G S
Sbjct: 768 LVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKS 826
Query: 267 SQEAASGLMPSRRLQRGEVEGLCTCLCT 294
+ + + G L
Sbjct: 827 LRLLSLHGNDISVVPEGAFNDLSALSHL 854
Score = 141 bits (353), Expect = 2e-32
Identities = 49/192 (25%), Positives = 81/192 (41%), Gaps = 9/192 (4%)
Query: 270 AASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLT 329
+ E+ DL NN IST+ +F + +L L LS NR+ C+
Sbjct: 759 LYLDGNQFTLVP-KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 817
Query: 330 SETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNR 389
TF GL L L++ GN S + G F++L AL + +G L CDC+++WL W ++
Sbjct: 818 PRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE 877
Query: 390 SLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALEL------HTHHLIPSLRQVVFQGD 443
+ CA P + L + + C+G +++ + P D
Sbjct: 878 YKEPG-IARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSD 936
Query: 444 RLPF-QCSASYL 454
+ F +C+ Y
Sbjct: 937 PVDFYRCTCPYG 948
Score = 118 bits (294), Expect = 2e-25
Identities = 38/220 (17%), Positives = 65/220 (29%), Gaps = 39/220 (17%)
Query: 245 WRLHSKCTLSMAGNQKNQGGSSSQEA---ASGLMPSRRLQRGEVEGLCTCLCTDLRNNII 301
++ + S+ + L + L L N +
Sbjct: 758 ELYLDGNQFTLVP----KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRL 813
Query: 302 STVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELP 361
+ P F GL L+ L L N I + F L L L I N
Sbjct: 814 RCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGAN-------------- 859
Query: 362 ALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCE 421
L CDC+++WL W ++ + CA P + L + + C+
Sbjct: 860 ----------PLYCDCNMQWLSDWVKSEYKEPG-IARCAGPGEMADKLLLTTPSKKFTCQ 908
Query: 422 GALEL------HTHHLIPSLRQVVFQGDRLPF-QCSASYL 454
G +++ + P D + F +C+ Y
Sbjct: 909 GPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYG 948
Score = 58.8 bits (141), Expect = 2e-07
Identities = 39/229 (17%), Positives = 64/229 (27%), Gaps = 35/229 (15%)
Query: 8 LLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLP 67
L L L+ +L +AP+A CP C CS G + G A R V ++P
Sbjct: 11 LSLGLVLAILNKVAPQA-----CP---AQCSCS-----GSTVDCHGLALRSV---PRNIP 54
Query: 68 -EPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHN 126
L N + L A + L ++
Sbjct: 55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNH 114
Query: 127 WSASDAGRP---ACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAA 183
A ++ +S Q+ A +G+ ++
Sbjct: 115 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDI------------KNLQLDYNQ 162
Query: 184 ALHTDTS---ARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFS 229
+ A E L+NN IT L SF + L + ++
Sbjct: 163 ISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Score = 53.4 bits (127), Expect = 8e-06
Identities = 16/136 (11%), Positives = 32/136 (22%), Gaps = 12/136 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEP---GLLPNGTVTLGNRFSTAPCPQSGLAQS 99
P G+ G D+ PE L + +G C L+
Sbjct: 816 IPPRTFDGLKSLRLLS--LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDW 873
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQ---D 156
+ ++ A + + + + C P V+ +
Sbjct: 874 VKSEYKEPGIA----RCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKN 929
Query: 157 QGSKYSFYGGKVKDEY 172
G+ S +
Sbjct: 930 DGTCNSDPVDFYRCTC 945
>dbj|BAB13406.1| (AB046800) KIAA1580 protein [Homo sapiens]
Length = 640
Score = 424 bits (1079), Expect = e-117
Identities = 84/468 (17%), Positives = 157/468 (32%), Gaps = 36/468 (7%)
Query: 124 GHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAA 183
N G + Q+ + ++
Sbjct: 64 RKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLE------------ILQLSRNH 111
Query: 184 ALHTDTSA---RSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSP 240
+ A + L +N++T + NG+F+ LS L++L +R + + A
Sbjct: 112 IRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRI 171
Query: 241 APRLWRLH-SKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN 299
LS +G S+ + + R + + L DL N
Sbjct: 172 PSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGN 229
Query: 300 IISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDE 359
+S ++PG+F GL L++L + ++I + F L L+ +N++ N + L +F
Sbjct: 230 HLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTP 289
Query: 360 LPALKVVDLGTEFLTCDCHLRWLLPWAQN-RSLQLSEHTLCAYPSALHAHALGSLQEAQL 418
L L+ + L C+C + WL W ++ + C P L +G L +
Sbjct: 290 LHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYF 349
Query: 419 CCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGIL 478
C + + P V +G +C A + T + W V
Sbjct: 350 TCYAPV-----IVEPPADLNVTEGMAAELKCRA--STSLTSVSWITPNGTVMTHGAYK-- 400
Query: 479 LAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLE---TSASYCP 535
+ +++ D T L +++ V +G + C VS + GN + + V T SY
Sbjct: 401 VRIAVLSDGT-----LNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFS 455
Query: 536 AERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRR 583
V RT + + T+V TR++ +
Sbjct: 456 TVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRSTEK 503
Score = 109 bits (272), Expect = 8e-23
Identities = 44/300 (14%), Positives = 78/300 (25%), Gaps = 44/300 (14%)
Query: 5 PARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSG-------------ERPKGLSGGV 51
P ++L L L++ A+ P C CS E P G+S
Sbjct: 25 PLLVVLLALQLLVVAGLVRAQTCP------SVCSCSNQFSKVICVRKNLREVPDGISTNT 78
Query: 52 PGPAR-------RRVVCSGGDLPEPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCP 104
+V S L L N T+ + L
Sbjct: 79 RLLNLHENQIQIIKVN-SFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLT 137
Query: 105 EQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSW----RQVPAYNAGQDQGSK 160
+ A ++S +L + + + I +++ + G +G
Sbjct: 138 TIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLS 197
Query: 161 YSFYGGKVKDEYLRRSPICRSAAALHTDTSAR-SWSEFRLLSNNKITGLRNGSFLGLSLL 219
Y + LS N ++ +R GSF GL L
Sbjct: 198 NLRYLNLAMC------------NLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHL 245
Query: 220 EKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRR 279
+KL M E+ A + + + L++ + + P
Sbjct: 246 QKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNC 305
Score = 56.5 bits (135), Expect = 8e-07
Identities = 10/99 (10%), Positives = 19/99 (19%), Gaps = 9/99 (9%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVT----LGNRFSTAPCPQSGLAQ 98
+ + + + +L P L L + C L+
Sbjct: 258 IERNAFDNLQSLVE--INLAHNNLTLLPH-DLFTPLHHLERIHLHHNPWNCNCDILWLSW 314
Query: 99 SFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPAC 137
+ + L G D C
Sbjct: 315 WIKDMAPSNTACCA--RCNTPPNLKGRYIGELDQNYFTC 351
>gb|AAF58053.1| (AE003808) CG8434 gene product [Drosophila melanogaster]
Length = 1173
Score = 421 bits (1073), Expect = e-117
Identities = 99/572 (17%), Positives = 179/572 (30%), Gaps = 54/572 (9%)
Query: 43 RPK--GLSGGVPG-PARRRVVCSGG----DLPEPPEPGLLPNGTVTLGNRFS---TAPCP 92
PK GLSG A + LP L N T+
Sbjct: 290 IPKFIGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVH 349
Query: 93 QSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFP---GPVSWRQVP 149
L+ + ++S A+ L+ + S + +++ Q+
Sbjct: 350 LI-LSFNEITNVNEHSFATLNN--LTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQLE 406
Query: 150 AYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTS---ARSWSEFRLLSNNKIT 206
+ +G ++ +S E L+ N+I+
Sbjct: 407 INWS-TFRGL------------ESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQIS 453
Query: 207 GLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSS 266
L L+ L L + + E S ++ Q
Sbjct: 454 SLSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHR 513
Query: 267 SQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTV-----QPGAFLGLGELKRLDLS 321
+ + LQ + + +LR N +S + F GL +L+RLDL
Sbjct: 514 LKTLNLAHNRLQYLQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLH 573
Query: 322 NNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRW 381
N + ++++ GL L LN+ N +S+Q F+ + L + + CDC L W
Sbjct: 574 GNNLKQISTKAMSGLNNLEILNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVW 633
Query: 382 LLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQ 441
W +NR Q +EH +C YP L L SL ++L C + + +
Sbjct: 634 FQQWLKNRFPQQAEHAVCGYPEHLLDRHLKSLSSSELVCVDSPK--PRVEQEPDDMLAVN 691
Query: 442 GDRLPFQCSASYLGNDT-------RIRWYHNRAP------VEGDEQAGILLAESLIHDCT 488
+ +C AS + +I+W H+ V + L + T
Sbjct: 692 AANITLECIASSPTAASLAAADELKIKWRHDNQHVQERPAVHDGASTETQIRHDLSTNQT 751
Query: 489 FITSELTLSHIGVWASGEWECTVSMAQG-NASKKVEIVVLETSASYCPAERVANNRGDFR 547
I L L+++ ++G ++C VS A G ++K +I + + + G+
Sbjct: 752 SIYGYLRLTNVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQVPSNLTLDAGE-M 810
Query: 548 WPRTLAGITAYQSCLQYPFTSVPLGGGAPGTR 579
+ + A R
Sbjct: 811 ARLVCSASGDPTPEIALQKFGGSEFPAATERR 842
Score = 137 bits (343), Expect = 3e-31
Identities = 41/230 (17%), Positives = 75/230 (31%), Gaps = 28/230 (12%)
Query: 166 GKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNN--------------KIT----- 206
+ L C S+ + L+NN +T
Sbjct: 225 CPKDCKCLNVLFDCDKLHLERVPV-LPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLK 283
Query: 207 -----GLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKN 261
+ F+GLS L+ L++ + + + S+ L
Sbjct: 284 RNLLEVIPK--FIGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSF 341
Query: 262 QGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLS 321
++ + L +L NN +ST+ F L +LK+L L+
Sbjct: 342 PKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKLALN 401
Query: 322 NNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTE 371
N++ + TF+GL + L + N +LQ GVF + ++ +DL
Sbjct: 402 FNQLE-INWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMN 450
Score = 39.3 bits (91), Expect = 0.13
Identities = 22/157 (14%), Positives = 40/157 (25%), Gaps = 15/157 (9%)
Query: 427 HTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHD 486
H L + G+ CSA I A +
Sbjct: 793 HPTFLQVPSNLTLDAGEMARLVCSA-SGDPTPEIALQKFGGSEF---PAATERRLQV--- 845
Query: 487 CTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCP--AERVANNRG 544
+ +++ SG + CT A G +VV + P + V R
Sbjct: 846 -IREENAFLITNAKPSDSGIYTCTALSAAGEIKVNATLVVNDKPQPSIPLVHQEVVVGRT 904
Query: 545 DFRWPRTLAGITAYQ---SCLQYPFTSVP--LGGGAP 576
+ ++ ++ + P + AP
Sbjct: 905 CVLQCLSETANADFELEHPHREWFKENKPIHISPTAP 941
>gb|AAD04309.1| (AF055585) neurogenic extracellular slit protein Slit2 [Homo
sapiens]
Length = 1521
Score = 421 bits (1072), Expect = e-116
Identities = 71/495 (14%), Positives = 127/495 (25%), Gaps = 97/495 (19%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 362 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA 421
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 422 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 477
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G ++ K + C + ++
Sbjct: 478 CSGTEDYRSKL---------SGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA 528
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + E+ A + L + L
Sbjct: 529 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 588
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G Q + GL + L +N I+TV PGAF L L
Sbjct: 589 VQHKMFKGLEKPQNLMLRSNRITCVGNDSFIGLSSVRMLSLYDNQITTVAPGAFDTLHSL 648
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 649 STLNLLAN------------------------------------------------PFNC 660
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHH-LIPS 434
+C+L WL W + + + ++ + C P L + + C+ + ++ L
Sbjct: 661 NCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRC 719
Query: 435 LRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQAGILLAESLIHD 486
+ + Y + + L L ++
Sbjct: 720 PTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNN 779
Query: 487 CTFITSELTLSHIGV 501
S + S++
Sbjct: 780 RISTLSNQSFSNMTQ 794
Score = 373 bits (949), Expect = e-102
Identities = 60/354 (16%), Positives = 109/354 (29%), Gaps = 36/354 (10%)
Query: 162 SFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEK 221
+ + + C A + +E L+ N IT + F GL L
Sbjct: 24 APQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRV 83
Query: 222 LLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQ 281
L + + E+ A ++ L + G + + +
Sbjct: 84 LQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIP 143
Query: 282 RGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLR 341
R G L N IS ++ GAF L +L+ L L+NN I L+ +F +P+L
Sbjct: 144 RKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKL-- 201
Query: 342 LNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAY 401
+ L + L CDCHL WL W + R ++ +T C
Sbjct: 202 ----------------------RTFRLHSNNLYCDCHLAWLSDWLRQRP-RVGLYTQCMG 238
Query: 402 PSALHAHALGSLQEAQLCCEG--ALELHTHHLIPSLRQVVFQGDRLPFQCS--ASYLGND 457
PS L H + +Q+ + C G + + ++ + + + N
Sbjct: 239 PSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNL 298
Query: 458 TR--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+ ++ L L ++ + + S
Sbjct: 299 PETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNS 352
Score = 307 bits (779), Expect = 3e-82
Identities = 56/312 (17%), Positives = 89/312 (27%), Gaps = 39/312 (12%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 362 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA 421
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 422 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 477
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G ++ K + C + ++
Sbjct: 478 CSGTEDYRSKL---------SGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA 528
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + E+ A + L + L
Sbjct: 529 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 588
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G Q + GL + L +N I+TV PGAF L L
Sbjct: 589 VQHKMFKGLEKPQNLMLRSNRITCVGNDSFIGLSSVRMLSLYDNQITTVAPGAFDTLHSL 648
Query: 316 KRLDLSNNRIGC 327
L+L N C
Sbjct: 649 STLNLLANPFNC 660
Score = 246 bits (623), Expect = 5e-64
Identities = 56/462 (12%), Positives = 101/462 (21%), Gaps = 85/462 (18%)
Query: 56 RRRVVCSGGDLPEPPEPGL-LPNGTVTLGNRFST--APCPQSGLAQSFRLCPEQYSNASG 112
+ + ++ T + C + L+ R P
Sbjct: 177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPR----VGL 232
Query: 113 WVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEY 172
+ L GHN + C S
Sbjct: 233 YTQCMGPSHLRGHNVAEVQKREFVCSGHQ-------------SFMAPSCSVLHCPAACTC 279
Query: 173 LRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDED 232
CR T+ L N I + G+F L ++ + + E
Sbjct: 280 SNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISEL 339
Query: 233 EKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCL 292
A + ++ +G S Q L+ + L
Sbjct: 340 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLN 399
Query: 293 CTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSL 352
L +N + T+ G F L ++ + L+ N
Sbjct: 400 LLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN----------------------------- 430
Query: 353 QPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGS 412
CDCHL+WL + ++ S C P L +G
Sbjct: 431 -------------------PFICDCHLKWLADYLHTNPIETSG-ARCTSPRRLANKRIGQ 470
Query: 413 LQEAQLCCEGALELHTHHLI------PSLRQVVFQGDRLPFQ----CSASYLGNDTRIRW 462
++ + C G + + + +G +
Sbjct: 471 IKSKKFRCSGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAEL 530
Query: 463 YHNRAPVEGDEQAGI------LLAESLIHDCTFITSELTLSH 498
N E GI L + ++ E
Sbjct: 531 RLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG 572
Score = 227 bits (575), Expect = 2e-58
Identities = 44/267 (16%), Positives = 93/267 (34%), Gaps = 11/267 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 529 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 588
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
VQ F GL + + L L +NRI C+ +++F GL + L++ N +++ PG FD L +L
Sbjct: 589 VQHKMFKGLEKPQNLMLRSNRITCVGNDSFIGLSSVRMLSLYDNQITTVAPGAFDTLHSL 648
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+C+L WL W + + + ++ + C P L + + C+
Sbjct: 649 STLNLLANPFNCNCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG 707
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQ 474
+ ++ L + + Y + +
Sbjct: 708 NDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN 767
Query: 475 AGILLAESLIHDCTFITSELTLSHIGV 501
L L ++ S + S++
Sbjct: 768 YKHLTLIDLSNNRISTLSNQSFSNMTQ 794
Score = 225 bits (570), Expect = 9e-58
Identities = 44/266 (16%), Positives = 93/266 (34%), Gaps = 11/266 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 529 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN 588
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
VQ F GL + + L L +NRI C+ +++F GL + L++ N +++ PG FD L +L
Sbjct: 589 VQHKMFKGLEKPQNLMLRSNRITCVGNDSFIGLSSVRMLSLYDNQITTVAPGAFDTLHSL 648
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+C+L WL W + + + ++ + C P L + + C+
Sbjct: 649 STLNLLANPFNCNCYLAWLGEWLRKKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDG 707
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQ 474
+ ++ L + + Y + +
Sbjct: 708 NDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN 767
Query: 475 AGILLAESLIHDCTFITSELTLSHIG 500
L L ++ S + S++
Sbjct: 768 YKHLTLIDLSNNRISTLSNQSFSNMT 793
Score = 216 bits (547), Expect = 4e-55
Identities = 61/531 (11%), Positives = 114/531 (20%), Gaps = 127/531 (23%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPE-----------PGLLPNGTVTLGNRFSTAPC 91
+G + R R+ + L PE L N + +
Sbjct: 94 IERGAFQDLKELERLRLNRNH--LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAV 151
Query: 92 PQSGLA-QSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRP--------------- 135
L ++ + A + L +N +
Sbjct: 152 DIKNLQLDYNQISCIED-GAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNN 210
Query: 136 ------------------------ACIFPGPVS------WRQVPAYNAGQ--DQGSKYSF 163
C+ P + ++ +G S
Sbjct: 211 LYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSV 270
Query: 164 YGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLL 223
CR T+ L N I + G+F L ++
Sbjct: 271 LHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRID 330
Query: 224 MRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRG 283
+ + E A + ++ +G S Q L+
Sbjct: 331 LSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 390
Query: 284 EVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLN 343
+ L L +N + T+ G F L ++ + L+ N
Sbjct: 391 AFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN-------------------- 430
Query: 344 ISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPS 403
CDCHL+WL + ++ S C P
Sbjct: 431 ----------------------------PFICDCHLKWLADYLHTNPIETSG-ARCTSPR 461
Query: 404 ALHAHALGSLQEAQLCCEGALELHTHHLI------PSLRQVVFQGDRLPFQ----CSASY 453
L +G ++ + C G + + + +G +
Sbjct: 462 RLANKRIGQIKSKKFRCSGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPE 521
Query: 454 LGNDTRIRWYHNRAPVEGDEQAGI------LLAESLIHDCTFITSELTLSH 498
N E GI L + ++ E
Sbjct: 522 HIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG 572
Score = 165 bits (415), Expect = 1e-39
Identities = 34/254 (13%), Positives = 58/254 (22%), Gaps = 25/254 (9%)
Query: 54 PARRRVVCSGGD----LPEPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSN 109
R+ C G D L L N T+ S L + P +
Sbjct: 605 LRSNRITCVGNDSFIGLSSVRMLSLYDNQITTVAPGAFDTLHSLSTL--NLLANPFNCNC 662
Query: 110 ASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPA---------YNAGQDQGSK 160
W+ +L G P C P +++P + G D S
Sbjct: 663 YLAWLGE----WLRKKRIV---TGNPRC--QKPYFLKEIPIQDVAIQDFTCDDGNDDNSC 713
Query: 161 YSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLE 220
+ L C + L N+ T + L
Sbjct: 714 SPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE-LSNYKHLT 772
Query: 221 KLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRL 280
+ + + + + L + S L + G S + + +
Sbjct: 773 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV 832
Query: 281 QRGEVEGLCTCLCT 294
G L
Sbjct: 833 PEGAFNDLSALSHL 846
Score = 141 bits (353), Expect = 2e-32
Identities = 49/192 (25%), Positives = 81/192 (41%), Gaps = 9/192 (4%)
Query: 270 AASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLT 329
+ E+ DL NN IST+ +F + +L L LS NR+ C+
Sbjct: 751 LYLDGNQFTLVP-KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 809
Query: 330 SETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNR 389
TF GL L L++ GN S + G F++L AL + +G L CDC+++WL W ++
Sbjct: 810 PRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE 869
Query: 390 SLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALEL------HTHHLIPSLRQVVFQGD 443
+ CA P + L + + C+G +++ + P D
Sbjct: 870 YKEPG-IARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSD 928
Query: 444 RLPF-QCSASYL 454
+ F +C+ Y
Sbjct: 929 PVDFYRCTCPYG 940
Score = 58.4 bits (140), Expect = 2e-07
Identities = 39/229 (17%), Positives = 64/229 (27%), Gaps = 35/229 (15%)
Query: 8 LLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLP 67
L L L+ +L +AP+A CP C CS G + G A R V ++P
Sbjct: 11 LSLGLVLAILNKVAPQA-----CP---AQCSCS-----GSTVDCHGLALRSV---PRNIP 54
Query: 68 -EPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHN 126
L N + L A + L ++
Sbjct: 55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNH 114
Query: 127 WSASDAGRP---ACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAA 183
A ++ +S Q+ A +G+ ++
Sbjct: 115 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDI------------KNLQLDYNQ 162
Query: 184 ALHTDTS---ARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFS 229
+ A E L+NN IT L SF + L + ++
Sbjct: 163 ISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Score = 53.4 bits (127), Expect = 8e-06
Identities = 16/136 (11%), Positives = 32/136 (22%), Gaps = 12/136 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEP---GLLPNGTVTLGNRFSTAPCPQSGLAQS 99
P G+ G D+ PE L + +G C L+
Sbjct: 808 IPPRTFDGLKSLRLLS--LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDW 865
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQ---D 156
+ ++ A + + + + C P V+ +
Sbjct: 866 VKSEYKEPGIA----RCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKN 921
Query: 157 QGSKYSFYGGKVKDEY 172
G+ S +
Sbjct: 922 DGTCNSDPVDFYRCTC 937
>gb|AAG36773.1| (AF210321) Slit2 [Danio rerio]
Length = 1512
Score = 414 bits (1054), Expect = e-114
Identities = 71/493 (14%), Positives = 127/493 (25%), Gaps = 97/493 (19%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PKGL G+ ++ C S DL L N T+ +
Sbjct: 353 ELPKGLFDGLFSLQLLLLNANKINCLRVDSFQDLQNLNLLSLYDNKLQTIAKGTFSSLRA 412
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA + P + S A + R L + +
Sbjct: 413 IQTLHLAQNPFMCDCHLKWLADYLQDNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 468
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G ++ K + C ++
Sbjct: 469 CSGVEDYRSKLG---------GDCFADLACPEKCRCEGTTVDCSGQKLTKIPDHIPQYTA 519
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + + E+ + + + L
Sbjct: 520 ELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGTFEGASGVNELILTSNRLEG 579
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+G + + G GL + L +N+I+++ PGAF L L
Sbjct: 580 VHYSMLKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITSMSPGAFDTLHSL 639
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 640 STLNLLAN------------------------------------------------PFNC 651
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHH-LIPS 434
+CHL WL W + + + ++ + C P L + + CE + ++ L
Sbjct: 652 NCHLAWLGEWLRKKRI-VTGNPRCQSPYFLKEIPIQDVAVQDFACEEGNDENSCSPLARC 710
Query: 435 LRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPVEG----DEQAGILLAESLIHD 486
+ + Y + L L ++
Sbjct: 711 PAECSCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNEFTQVPLELSNYKHLTLIDLSNN 770
Query: 487 CTFITSELTLSHI 499
S + S++
Sbjct: 771 QISTLSNHSFSNM 783
Score = 349 bits (888), Expect = 4e-95
Identities = 57/353 (16%), Positives = 107/353 (30%), Gaps = 34/353 (9%)
Query: 161 YSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLE 220
+ + C + + E L+ N +T + F GL L
Sbjct: 16 AGAQSCPSQCSCSGTAVDCHGQSLRSVPRNIPRNVERLDLNANNLTKITKADFAGLKNLR 75
Query: 221 KLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRL 280
L + + E+ A ++ L + G + + +
Sbjct: 76 VLQLMENKISSIERGAFQDLQELERLRLNRNNLQVLPELLFLGTTKLFRLDLSENQIQGI 135
Query: 281 QRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLL 340
R G L N IS ++ GAF LG+L+ L L+NN I L+ +F
Sbjct: 136 PRKAFRGSTEIKNLQLDYNQISCIEDGAFRALGDLEVLTLNNNNISRLSVASFNH----- 190
Query: 341 RLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCA 400
+P L+ L + L CDC++ WL W + R +L +T C
Sbjct: 191 -------------------MPKLRTFRLHSNNLLCDCNVAWLSDWLRQRP-RLGLYTQCM 230
Query: 401 YPSALHAHALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCS--ASYLGNDT 458
P +L H + +Q+ + C G + ++ + + + N
Sbjct: 231 APPSLRGHNIAEVQKKEFMCTGPQSHSSCSVLQCPELCTCSNNVVDCRGKGLTEIPTNLP 290
Query: 459 R--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+ ++ L L ++ + + + S
Sbjct: 291 ETITEIRLEQNSIKIIPAGAFAPYKRLRRIDLSNNQITELASDSFQGLRSLNS 343
Score = 306 bits (777), Expect = 4e-82
Identities = 54/312 (17%), Positives = 90/312 (28%), Gaps = 39/312 (12%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PKGL G+ ++ C S DL L N T+ +
Sbjct: 353 ELPKGLFDGLFSLQLLLLNANKINCLRVDSFQDLQNLNLLSLYDNKLQTIAKGTFSSLRA 412
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA + P + S A + R L + +
Sbjct: 413 IQTLHLAQNPFMCDCHLKWLADYLQDNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 468
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G ++ K + C ++
Sbjct: 469 CSGVEDYRSKLG---------GDCFADLACPEKCRCEGTTVDCSGQKLTKIPDHIPQYTA 519
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + + E+ + + + L
Sbjct: 520 ELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGTFEGASGVNELILTSNRLEG 579
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+G + + G GL + L +N+I+++ PGAF L L
Sbjct: 580 VHYSMLKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITSMSPGAFDTLHSL 639
Query: 316 KRLDLSNNRIGC 327
L+L N C
Sbjct: 640 STLNLLANPFNC 651
Score = 244 bits (617), Expect = 3e-63
Identities = 62/462 (13%), Positives = 107/462 (22%), Gaps = 87/462 (18%)
Query: 56 RRRVVCSGGDLPEPPEPGL-LPNGTVTLGNRFST--APCPQSGLAQSFRLCPEQYSNASG 112
+ + ++ T + C + L+ R P
Sbjct: 170 LEVLTLNNNNISRLSVASFNHMPKLRTFRLHSNNLLCDCNVAWLSDWLRQRPRL----GL 225
Query: 113 WVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEY 172
+ A L GHN + C P S S
Sbjct: 226 YTQCMAPPSLRGHNIAEVQKKEFMCTGPQSHSS---------------CSVLQCPELCTC 270
Query: 173 LRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDED 232
CR T+ L N I + G+F L ++ + + E
Sbjct: 271 SNNVVDCRGKGLTEIPTNLPETITEIRLEQNSIKIIPAGAFAPYKRLRRIDLSNNQITEL 330
Query: 233 EKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCL 292
+ + ++ G S Q L+ + L
Sbjct: 331 ASDSFQGLRSLNSLVLYGNKITELPKGLFDGLFSLQLLLLNANKINCLRVDSFQDLQNLN 390
Query: 293 CTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSL 352
L +N + T+ G F L ++ L L+ N
Sbjct: 391 LLSLYDNKLQTIAKGTFSSLRAIQTLHLAQN----------------------------- 421
Query: 353 QPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGS 412
CDCHL+WL + Q+ ++ S C P L +G
Sbjct: 422 -------------------PFMCDCHLKWLADYLQDNPIETSG-ARCTSPRRLANKRIGQ 461
Query: 413 LQEAQLCCEGALELHTHHLI------PSLRQVVFQGDRLPFQC----SASYLGNDTRIRW 462
++ + C G + + + +G +
Sbjct: 462 IKSKKFRCSGVEDYRSKLGGDCFADLACPEKCRCEGTTVDCSGQKLTKIPDHIPQYTAEL 521
Query: 463 YHNRAPVEGDEQAGI------LLAESLIHDCTFITSELTLSH 498
N E GI L +L ++ E T
Sbjct: 522 RLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGTFEG 563
Score = 223 bits (565), Expect = 3e-57
Identities = 47/265 (17%), Positives = 91/265 (33%), Gaps = 11/265 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 520 ELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGTFEGASGVNELILTSNRLEG 579
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
V GLG L+ L L +NRI C+ + +F GL + L++ N+ +S+ PG FD L +L
Sbjct: 580 VHYSMLKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITSMSPGAFDTLHSL 639
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+CHL WL W + + + ++ + C P L + + CE
Sbjct: 640 STLNLLANPFNCNCHLAWLGEWLRKKRI-VTGNPRCQSPYFLKEIPIQDVAVQDFACEEG 698
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPVEG----DEQ 474
+ ++ L + + Y +
Sbjct: 699 NDENSCSPLARCPAECSCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNEFTQVPLELSN 758
Query: 475 AGILLAESLIHDCTFITSELTLSHI 499
L L ++ S + S++
Sbjct: 759 YKHLTLIDLSNNQISTLSNHSFSNM 783
Score = 223 bits (565), Expect = 3e-57
Identities = 47/265 (17%), Positives = 91/265 (33%), Gaps = 11/265 (4%)
Query: 245 WRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
+ ++ + ++ ++ G EG L +N +
Sbjct: 520 ELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGTFEGASGVNELILTSNRLEG 579
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPAL 363
V GLG L+ L L +NRI C+ + +F GL + L++ N+ +S+ PG FD L +L
Sbjct: 580 VHYSMLKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITSMSPGAFDTLHSL 639
Query: 364 KVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGA 423
++L C+CHL WL W + + + ++ + C P L + + CE
Sbjct: 640 STLNLLANPFNCNCHLAWLGEWLRKKRI-VTGNPRCQSPYFLKEIPIQDVAVQDFACEEG 698
Query: 424 LELHTHH-LIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPVEG----DEQ 474
+ ++ L + + Y +
Sbjct: 699 NDENSCSPLARCPAECSCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNEFTQVPLELSN 758
Query: 475 AGILLAESLIHDCTFITSELTLSHI 499
L L ++ S + S++
Sbjct: 759 YKHLTLIDLSNNQISTLSNHSFSNM 783
Score = 163 bits (410), Expect = 6e-39
Identities = 37/281 (13%), Positives = 64/281 (22%), Gaps = 42/281 (14%)
Query: 41 GERPKGLSGGVPGPAR--RRVVC----SGGDLPEPPEPGLLPNGTVTLGN---------- 84
KGL GG+ R+ C S L L N ++
Sbjct: 582 YSMLKGL-GGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITSMSPGAFDTLHSLS 640
Query: 85 ------RFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACI 138
C + L + R +G ++ FL AC
Sbjct: 641 TLNLLANPFNCNCHLAWLGEWLRKKRI----VTGNPRCQSPYFLKEIPIQDVAVQDFAC- 695
Query: 139 FPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFR 198
G D+ S + L C +
Sbjct: 696 -------------EEGNDENSCSPLARCPAECSCLDTVVRCSNKGLKVLPKGIPRDVTEL 742
Query: 199 LLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGN 258
L N+ T + L + + + + + + L + S L
Sbjct: 743 YLDGNEFTQVPLE-LSNYKHLTLIDLSNNQISTLSNHSFSNMSELLTLILSYNRLRCIPA 801
Query: 259 QKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN 299
+ G S + + + G + L + L N
Sbjct: 802 KAFDGLKSLRLLSLHGNDIAVIPDGAFKDLSSLSHLALGAN 842
Score = 136 bits (341), Expect = 6e-31
Identities = 46/192 (23%), Positives = 78/192 (39%), Gaps = 9/192 (4%)
Query: 270 AASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLT 329
++ + DL NN IST+ +F + EL L LS NR+ C+
Sbjct: 742 LYLDGNEFTQVPLE-LSNYKHLTLIDLSNNQISTLSNHSFSNMSELLTLILSYNRLRCIP 800
Query: 330 SETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNR 389
++ F GL L L++ GN + + G F +L +L + LG L CDCH++WL W ++
Sbjct: 801 AKAFDGLKSLRLLSLHGNDIAVIPDGAFKDLSSLSHLALGANPLYCDCHMQWLSDWVKSG 860
Query: 390 SLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALEL------HTHHLIPSLRQVVFQGD 443
+ C P + L + + C G +++ + P
Sbjct: 861 YKEPG-IARCTGPGDMTDKLLLTTPSKKFTCTGPVDVSILAKCNPCLSNPCKNDGTCSNH 919
Query: 444 RLPF-QCSASYL 454
+ F +C+ Y
Sbjct: 920 PVDFYRCTCPYG 931
Score = 49.9 bits (118), Expect = 8e-05
Identities = 16/107 (14%), Positives = 28/107 (25%), Gaps = 9/107 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPE---PGLLPNGTVTLGNRFSTAPCPQSGLAQS 99
P G+ G D+ P+ L + LG C L+
Sbjct: 799 IPAKAFDGLKSLRLLS--LHGNDIAVIPDGAFKDLSSLSHLALGANPLYCDCHMQWLSDW 856
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWR 146
+ ++ A +T + + + C P VS
Sbjct: 857 VKSGYKEPGIA----RCTGPGDMTDKLLLTTPSKKFTCTGPVDVSIL 899
Score = 40.9 bits (95), Expect = 0.043
Identities = 31/181 (17%), Positives = 41/181 (22%), Gaps = 16/181 (8%)
Query: 22 PEARGAPGCPLSIRSCKCSGE----RPKGLSGGVPGPARR-----RVVCSGGDLPEPPEP 72
P AR C +CS + PKG+ V +V +
Sbjct: 706 PLARCPAECSCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNEFTQVPLELSNYKHLTLI 765
Query: 73 GLLPNGTVTLGNRFSTAPCPQSGL-AQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASD 131
L N TL N + L RL G S L G++ +
Sbjct: 766 DLSNNQISTLSNHSFSNMSELLTLILSYNRLRCIPAKAFDGLK-SLRLLSLHGNDIAVIP 824
Query: 132 AGRPACIFPGPVSWRQV-PAYNAGQDQGSKY---SFYGGKVKDEYLRRSPICRSAAALHT 187
G + P Y Q S Y L T
Sbjct: 825 DGAFKDLSSLSHLALGANPLYCDCHMQWLSDWVKSGYKEPGIARCTGPG-DMTDKLLLTT 883
Query: 188 D 188
Sbjct: 884 P 884
Score = 36.2 bits (83), Expect = 1.1
Identities = 20/172 (11%), Positives = 36/172 (20%), Gaps = 32/172 (18%)
Query: 8 LLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARR------RVVC 61
+L LL GA CP C CSG + R R+
Sbjct: 8 VLCALLC---------GAGAQSCP---SQCSCSGTAVDCHGQSLRSVPRNIPRNVERLDL 55
Query: 62 SGGDLP-----------EPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNA 110
+ +L L+ N ++ L +
Sbjct: 56 NANNLTKITKADFAGLKNLRVLQLMENKISSIERGAFQDLQELERLRLNRNNLQVLPELL 115
Query: 111 SGWVSSEAARFLTGHNWSASDAGRPACI---FPGPVSWRQVPAYNAGQDQGS 159
+ L+ + + + Q+ G +
Sbjct: 116 FLGTTKLFRLDLSENQIQGIPRKAFRGSTEIKNLQLDYNQISCIEDGAFRAL 167
>gb|AAD38940.2| (AF141386) SLIT-2 [Rattus norvegicus]
Length = 796
Score = 389 bits (990), Expect = e-107
Identities = 68/459 (14%), Positives = 119/459 (25%), Gaps = 93/459 (20%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 366 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTVAKGTFSALRA 425
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 426 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 481
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G ++ K + C + ++
Sbjct: 482 CSGTEDYRSKL---------SGDCFADLACPEKCRCEGTTVDCSNQKLNKIPDHIPQYTA 532
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + + E+ A + L + L
Sbjct: 533 ELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGAFEGASGVNEILLTSNRLEN 592
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G S + + GL + L +N I+TV PGAF L L
Sbjct: 593 VQHKMFKGLESLKTLMLRSNRISCVGNDSFTGLGSVRLLSLYDNQITTVAPGAFGTLHSL 652
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 653 STLNLLAN------------------------------------------------PFNC 664
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHH-LIPS 434
+CHL WL W + + + ++ + C P L + + C+ + ++ L
Sbjct: 665 NCHLAWLGEWLRRKRI-VTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRC 723
Query: 435 LRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV 469
+ + Y +
Sbjct: 724 PSECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQF 762
Score = 363 bits (923), Expect = 3e-99
Identities = 63/358 (17%), Positives = 108/358 (29%), Gaps = 40/358 (11%)
Query: 162 SFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEK 221
+ + + + C A + +E L+ N IT + F GL L
Sbjct: 24 APHACPAQCSCSGSTVDCHGLALRIVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRI 83
Query: 222 LLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQ 281
L + + E+ A ++ L + G + + +
Sbjct: 84 LQLMENKISTIERGAFHDLKELERLRLNRNNLQLFPELLFLGTAKLYRLDLSENQIQAIP 143
Query: 282 RGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLR 341
R G L N IS ++ GAF L +L+ L L+NN I L+ +F
Sbjct: 144 RKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNH------ 197
Query: 342 LNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAY 401
+P L+ L + L CDCHL WL W + R ++ +T C
Sbjct: 198 ------------------MPKLRTFRLHSNNLYCDCHLAWLSDWLRQRP-RVGLYTQCMG 238
Query: 402 PSALHAHALGSLQEAQLCCEGALELHTHHLIPSLR------QVVFQGDRLPFQCS--ASY 453
PS L H + +Q+ + C E H + PS + + +
Sbjct: 239 PSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPIACTCSNNIVDCRGKGLTEI 298
Query: 454 LGNDTR--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
N + + L L ++ + + S
Sbjct: 299 PTNLPETITEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISELAPDAFQGLRSLNS 356
Score = 309 bits (785), Expect = 5e-83
Identities = 56/312 (17%), Positives = 91/312 (28%), Gaps = 39/312 (12%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PK L G+ ++ C + DL L N T+ +
Sbjct: 366 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTVAKGTFSALRA 425
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A + R L + +
Sbjct: 426 IQTMHLAQNPFICDCHLKWLADYLHTNPIETSGA----RCTSPRRLANKRIGQIKSKKFR 481
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G ++ K + C + ++
Sbjct: 482 CSGTEDYRSKL---------SGDCFADLACPEKCRCEGTTVDCSNQKLNKIPDHIPQYTA 532
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+ T L G F L L K+ + + + E+ A + L + L
Sbjct: 533 ELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGAFEGASGVNEILLTSNRLEN 592
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
++ +G S + + GL + L +N I+TV PGAF L L
Sbjct: 593 VQHKMFKGLESLKTLMLRSNRISCVGNDSFTGLGSVRLLSLYDNQITTVAPGAFGTLHSL 652
Query: 316 KRLDLSNNRIGC 327
L+L N C
Sbjct: 653 STLNLLANPFNC 664
Score = 246 bits (622), Expect = 6e-64
Identities = 58/462 (12%), Positives = 104/462 (21%), Gaps = 81/462 (17%)
Query: 56 RRRVVCSGGDLPEPPEPGL-LPNGTVTLGNRFST--APCPQSGLAQSFRLCPEQYSNASG 112
+ + ++ T + C + L+ R P
Sbjct: 177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPR----VGL 232
Query: 113 WVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEY 172
+ L GHN + C + S +
Sbjct: 233 YTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSC---------SVLHCPIACTC 283
Query: 173 LRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDED 232
CR T+ L N I + G+F L +L + + E
Sbjct: 284 SNNIVDCRGKGLTEIPTNLPETITEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISEL 343
Query: 233 EKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCL 292
A + ++ +G S Q L+ + L
Sbjct: 344 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLN 403
Query: 293 CTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSL 352
L +N + TV TF L + ++++ N
Sbjct: 404 LLSLYDNKLQTV------------------------AKGTFSALRAIQTMHLAQN----- 434
Query: 353 QPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGS 412
CDCHL+WL + ++ S C P L +G
Sbjct: 435 -------------------PFICDCHLKWLADYLHTNPIETSG-ARCTSPRRLANKRIGQ 474
Query: 413 LQEAQLCCEGALELHTHHLI------PSLRQVVFQGDRLPFQ----CSASYLGNDTRIRW 462
++ + C G + + + +G +
Sbjct: 475 IKSKKFRCSGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPDHIPQYTAEL 534
Query: 463 YHNRAPVEGDEQAGI------LLAESLIHDCTFITSELTLSH 498
N E GI L +L ++ E
Sbjct: 535 RLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGAFEG 576
>pir||T13953 MEGF5 protein - rat
dbj|BAA32461.1| (AB011531) MEGF5 [Rattus norvegicus]
Length = 1523
Score = 385 bits (979), Expect = e-106
Identities = 77/493 (15%), Positives = 130/493 (25%), Gaps = 98/493 (19%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PKGL G+ ++ C + DL L N T+
Sbjct: 369 EIPKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQS 428
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA + P + S A + R L S + +
Sbjct: 429 IQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGA----RCSSPRRLANKRISQIKSKKFR 484
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C R + K C + + ++
Sbjct: 485 CSGSEDYRNR---------FSSECFMDLVCPEKCRCEGTIVDCSNQKLSRIPSHLPEYTT 535
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L++N I L G F L L K+ + + E + A A + + L
Sbjct: 536 DLRLNDNDIAVLEATGIFKKLPNLRKINLSNNRIKEVREGAFDGAAGVQELMLTGNQLET 595
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G S + + GL + L +N I+T+ PGAF L L
Sbjct: 596 MHGRMFRGLSGLKTLMLRSNLISCVNNDTFAGLSSVRLLSLYDNRITTISPGAFTTLVSL 655
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
++L +N C
Sbjct: 656 STINLLSN------------------------------------------------PFNC 667
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIP-S 434
+CH+ WL W + R + +S + C P L + + CEG E ++ L P
Sbjct: 668 NCHMAWLGRWLRKRRI-VSGNPRCQKPFFLKEIPIQDVAIQDFTCEG-NEENSCQLSPRC 725
Query: 435 LRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQAGILLAESLIHD 486
Q + Y + + L L ++
Sbjct: 726 PEQCTCVETVVRCSNRGLHTLPKGMPKDVTELYLEGNHLTAVPKELSTFRQLTLIDLSNN 785
Query: 487 CTFITSELTLSHI 499
+ + T S++
Sbjct: 786 SISMLTNHTFSNM 798
Score = 385 bits (979), Expect = e-106
Identities = 77/493 (15%), Positives = 130/493 (25%), Gaps = 98/493 (19%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PKGL G+ ++ C + DL L N T+
Sbjct: 369 EIPKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQS 428
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA + P + S A + R L S + +
Sbjct: 429 IQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGA----RCSSPRRLANKRISQIKSKKFR 484
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C R + K C + + ++
Sbjct: 485 CSGSEDYRNR---------FSSECFMDLVCPEKCRCEGTIVDCSNQKLSRIPSHLPEYTT 535
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L++N I L G F L L K+ + + E + A A + + L
Sbjct: 536 DLRLNDNDIAVLEATGIFKKLPNLRKINLSNNRIKEVREGAFDGAAGVQELMLTGNQLET 595
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G S + + GL + L +N I+T+ PGAF L L
Sbjct: 596 MHGRMFRGLSGLKTLMLRSNLISCVNNDTFAGLSSVRLLSLYDNRITTISPGAFTTLVSL 655
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
++L +N C
Sbjct: 656 STINLLSN------------------------------------------------PFNC 667
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIP-S 434
+CH+ WL W + R + +S + C P L + + CEG E ++ L P
Sbjct: 668 NCHMAWLGRWLRKRRI-VSGNPRCQKPFFLKEIPIQDVAIQDFTCEG-NEENSCQLSPRC 725
Query: 435 LRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQAGILLAESLIHD 486
Q + Y + + L L ++
Sbjct: 726 PEQCTCVETVVRCSNRGLHTLPKGMPKDVTELYLEGNHLTAVPKELSTFRQLTLIDLSNN 785
Query: 487 CTFITSELTLSHI 499
+ + T S++
Sbjct: 786 SISMLTNHTFSNM 798
Score = 347 bits (882), Expect = 3e-94
Identities = 61/368 (16%), Positives = 107/368 (28%), Gaps = 37/368 (10%)
Query: 145 WRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNK 204
++ A S K S C +E L N
Sbjct: 13 RARLALALALASILSGPPAAACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNN 72
Query: 205 ITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGG 264
IT + F GL L L + + E+ A +K L + Q
Sbjct: 73 ITRITKMDFTGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQST 132
Query: 265 SSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNR 324
+ + R G+ L NN IS ++ GAF L +L+ L L+NN
Sbjct: 133 PKLTRLDLSENQIQGIPRKAFRGVTGVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNN 192
Query: 325 IGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLP 384
I + +F + +P ++ + L + L CDCHL WL
Sbjct: 193 ISRILVTSF------------------------NHMPKIRTLRLHSNHLYCDCHLAWLSD 228
Query: 385 WAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHT---HHLIPSLRQVVFQ 441
W + R + + TLC P L ++ +Q+ + C G + +
Sbjct: 229 WLRQRRT-IGQFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAPACNANSLSCPSACSCS 287
Query: 442 GDRLPFQCS--ASYLGNDTR--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITS 492
+ + + N + + ++ Q L + + +
Sbjct: 288 NNIVDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGAFIQYKKLKRIDISKNQISDIA 347
Query: 493 ELTLSHIG 500
+
Sbjct: 348 PDAFQGLK 355
Score = 249 bits (631), Expect = 7e-65
Identities = 65/498 (13%), Positives = 116/498 (23%), Gaps = 108/498 (21%)
Query: 43 RPKGLSGGVPG-----PARRRVVC----SGGDLPEPPEPGLLPN--------------GT 79
P+ GV G + C + L + L N
Sbjct: 148 IPRKAFRGVTGVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKI 207
Query: 80 VTL---GNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
TL N C + L+ R Q + A L G + +
Sbjct: 208 RTLRLHSNHLY-CDCHLAWLSDWLR----QRRTIGQFTLCMAPVHLRGFSVADVQKKEYV 262
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C P A + CR +
Sbjct: 263 CP---------GPHSEAPACNANS---LSCPSACSCSNNIVDCRGKGLTEIPANLPEGIV 310
Query: 197 FRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMA 256
L N I + G+F+ L+++ + + + A + ++
Sbjct: 311 EIRLEQNSIKSIPAGAFIQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEI 370
Query: 257 GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELK 316
G S Q L+ + L L +N + T+ G F L ++
Sbjct: 371 PKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQ 430
Query: 317 RLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCD 376
L L+ N CD
Sbjct: 431 TLHLAQN------------------------------------------------PFVCD 442
Query: 377 CHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIP--- 433
CHL+WL + Q+ ++ S C+ P L + ++ + C G+ +
Sbjct: 443 CHLKWLADYLQDNPIETSG-ARCSSPRRLANKRISQIKSKKFRCSGSEDYRNRFSSECFM 501
Query: 434 ---SLRQVVFQGDRLPFQC----SASYLGNDTRIRWYHNRAPVEGDEQAG------ILLA 480
+ +G + + N + E G L
Sbjct: 502 DLVCPEKCRCEGTIVDCSNQKLSRIPSHLPEYTTDLRLNDNDIAVLEATGIFKKLPNLRK 561
Query: 481 ESLIHDCTFITSELTLSH 498
+L ++ E
Sbjct: 562 INLSNNRIKEVREGAFDG 579
Score = 165 bits (414), Expect = 2e-39
Identities = 45/311 (14%), Positives = 76/311 (23%), Gaps = 43/311 (13%)
Query: 43 RPKGLSGGVPG-----PARRRVVC----SGGDLPEPPEPGLLPN--------------GT 79
P+ GV G + C + L + L N
Sbjct: 148 IPRKAFRGVTGVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKI 207
Query: 80 VTL---GNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
TL N C + L+ R Q + A L G + +
Sbjct: 208 RTLRLHSNHLY-CDCHLAWLSDWLR----QRRTIGQFTLCMAPVHLRGFSVADVQKKEYV 262
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C P A + CR +
Sbjct: 263 CP---------GPHSEAPACNANS---LSCPSACSCSNNIVDCRGKGLTEIPANLPEGIV 310
Query: 197 FRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMA 256
L N I + G+F+ L+++ + + + A + ++
Sbjct: 311 EIRLEQNSIKSIPAGAFIQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEI 370
Query: 257 GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELK 316
G S Q L+ + L L +N + T+ G F L ++
Sbjct: 371 PKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQ 430
Query: 317 RLDLSNNRIGC 327
L L+ N C
Sbjct: 431 TLHLAQNPFVC 441
Score = 155 bits (389), Expect = 2e-36
Identities = 35/284 (12%), Positives = 58/284 (20%), Gaps = 41/284 (14%)
Query: 41 GERPKGLSGGVPGPAR-RRVVCSGGD----LPEPPEPGLLPNGTVTLGN----------- 84
G +GLSG R + C D L L N T+
Sbjct: 598 GRMFRGLSGLKTLMLRSNLISCVNNDTFAGLSSVRLLSLYDNRITTISPGAFTTLVSLST 657
Query: 85 -----RFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIF 139
C + L + R SG + FL C
Sbjct: 658 INLLSNPFNCNCHMAWLGRWLRKRRI----VSGNPRCQKPFFLKEIPIQDVAIQDFTC-- 711
Query: 140 PGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRL 199
G ++ S + + C +
Sbjct: 712 -------------EGNEENSCQLSPRCPEQCTCVETVVRCSNRGLHTLPKGMPKDVTELY 758
Query: 200 LSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQ 259
L N +T + L + + + + + + S L
Sbjct: 759 LEGNHLTAVPKE-LSTFRQLTLIDLSNNSISMLTNHTFSNMSHLSTLILSYNRLRCIPVH 817
Query: 260 KNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
G S + + G L + L N +
Sbjct: 818 AFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGINPLHC 861
Score = 136 bits (340), Expect = 8e-31
Identities = 49/206 (23%), Positives = 76/206 (36%), Gaps = 19/206 (9%)
Query: 261 NQGGSSS--------QEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGL 312
N+G + E + + DL NN IS + F +
Sbjct: 740 NRGLHTLPKGMPKDVTELYLEGNHLTAVPKELSTFRQ-LTLIDLSNNSISMLTNHTFSNM 798
Query: 313 GELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEF 372
L L LS NR+ C+ F GL L L + GN SS+ G F++L +L + LG
Sbjct: 799 SHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGINP 858
Query: 373 LTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALEL------ 426
L CDC LRWL W + + C+ P ++ L + + C+G +++
Sbjct: 859 LHCDCSLRWLSEWIKAGYKEPG-IARCSSPESMADRLLLTTPTHRFQCKGPVDINIVAKC 917
Query: 427 HTHHLIPSLRQVVFQGDRL---PFQC 449
+ P D + C
Sbjct: 918 NACLSSPCKNNGTCSQDPVEQYRCTC 943
Score = 114 bits (284), Expect = 3e-24
Identities = 35/214 (16%), Positives = 58/214 (26%), Gaps = 35/214 (16%)
Query: 245 WRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTV 304
L+ ++ L + L N + +
Sbjct: 756 ELYLEGNHLTAV-PKELSTFRQLTLIDLSNNSISMLTNHTFSNMSHLSTLILSYNRLRCI 814
Query: 305 QPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALK 364
AF GL L+ L L N I + +F L L L +
Sbjct: 815 PVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLAL-------------------- 854
Query: 365 VVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGAL 424
G L CDC LRWL W + + C+ P ++ L + + C+G +
Sbjct: 855 ----GINPLHCDCSLRWLSEWIKAGYKEPG-IARCSSPESMADRLLLTTPTHRFQCKGPV 909
Query: 425 EL------HTHHLIPSLRQVVFQGDRL---PFQC 449
++ + P D + C
Sbjct: 910 DINIVAKCNACLSSPCKNNGTCSQDPVEQYRCTC 943
Score = 45.6 bits (107), Expect = 0.002
Identities = 16/106 (15%), Positives = 30/106 (28%), Gaps = 9/106 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPG---LLPNGTVTLGNRFSTAPCPQSGLAQS 99
P G+ R + G D+ PE L + LG C L++
Sbjct: 814 IPVHAFNGLRSL--RVLTLHGNDISSVPEGSFNDLTSLSHLALGINPLHCDCSLRWLSEW 871
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSW 145
+ ++ A + + + R C P ++
Sbjct: 872 IKAGYKEPGIA----RCSSPESMADRLLLTTPTHRFQCKGPVDINI 913
Score = 42.1 bits (98), Expect = 0.022
Identities = 4/79 (5%), Positives = 11/79 (13%), Gaps = 9/79 (11%)
Query: 432 IPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV-----EGDEQAGILLAES 482
+ + R +R + L
Sbjct: 32 AACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFTGLKNLRVLH 91
Query: 483 LIHDCTFITSELTLSHIGV 501
L + + +
Sbjct: 92 LEDNQVSVIERGAFQDLKQ 110
>ref|NP_003053.1| slit (Drosophila) homolog 3; slit2; slit (Drosophila) homolog 2
[Homo sapiens]
dbj|BAA35186.1| (AB017169) Slit-3 protein [Homo sapiens]
Length = 1523
Score = 384 bits (978), Expect = e-105
Identities = 73/492 (14%), Positives = 126/492 (24%), Gaps = 96/492 (19%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E KGL G+ ++ C + DL L N T+
Sbjct: 369 EIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQS 428
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA + P + S A + R L S + +
Sbjct: 429 IQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGA----RCSSPRRLANKRISQIKSKKFR 484
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C R + K C + + + +
Sbjct: 485 CSGSEDYRSR---------FSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVT 535
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L++N+++ L G F L L K+ + + E + A A + + L
Sbjct: 536 DLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLET 595
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G S + + GL + L +N I+T+ PGAF L L
Sbjct: 596 VHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSL 655
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
++L +N C
Sbjct: 656 STINLLSN------------------------------------------------PFNC 667
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSL 435
+CHL WL W + R + +S + C P L + + C+G E
Sbjct: 668 NCHLAWLGKWLRKRRI-VSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCP 726
Query: 436 RQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPVEG----DEQAGILLAESLIHDC 487
Q + Y + L L ++
Sbjct: 727 EQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNS 786
Query: 488 TFITSELTLSHI 499
+ + T S++
Sbjct: 787 ISMLTNYTFSNM 798
Score = 384 bits (978), Expect = e-105
Identities = 73/492 (14%), Positives = 126/492 (24%), Gaps = 96/492 (19%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E KGL G+ ++ C + DL L N T+
Sbjct: 369 EIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQS 428
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA + P + S A + R L S + +
Sbjct: 429 IQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGA----RCSSPRRLANKRISQIKSKKFR 484
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C R + K C + + + +
Sbjct: 485 CSGSEDYRSR---------FSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVT 535
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L++N+++ L G F L L K+ + + E + A A + + L
Sbjct: 536 DLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLET 595
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G S + + GL + L +N I+T+ PGAF L L
Sbjct: 596 VHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSL 655
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
++L +N C
Sbjct: 656 STINLLSN------------------------------------------------PFNC 667
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSL 435
+CHL WL W + R + +S + C P L + + C+G E
Sbjct: 668 NCHLAWLGKWLRKRRI-VSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCP 726
Query: 436 RQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPVEG----DEQAGILLAESLIHDC 487
Q + Y + L L ++
Sbjct: 727 EQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNS 786
Query: 488 TFITSELTLSHI 499
+ + T S++
Sbjct: 787 ISMLTNYTFSNM 798
Score = 350 bits (889), Expect = 4e-95
Identities = 61/368 (16%), Positives = 105/368 (27%), Gaps = 37/368 (10%)
Query: 145 WRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNK 204
++ A S K S C +E L N
Sbjct: 13 RARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNN 72
Query: 205 ITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGG 264
IT + F GL L L + + E+ A +K L + Q
Sbjct: 73 ITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQST 132
Query: 265 SSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNR 324
+ + R G+ L NN IS ++ GAF L +L+ L L+NN
Sbjct: 133 PKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNN 192
Query: 325 IGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLP 384
I + +F + +P ++ + L + L CDCHL WL
Sbjct: 193 ISRILVTSF------------------------NHMPKIRTLRLHSNHLYCDCHLAWLSD 228
Query: 385 WAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHT---HHLIPSLRQVVFQ 441
W + R + + TLC P L + +Q+ + C + I
Sbjct: 229 WLRQRRT-VGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCS 287
Query: 442 GDRLPFQCSA--SYLGNDTR--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITS 492
+ + + N + + ++ Q L + + +
Sbjct: 288 NNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIA 347
Query: 493 ELTLSHIG 500
+
Sbjct: 348 PDAFQGLK 355
Score = 250 bits (632), Expect = 5e-65
Identities = 60/454 (13%), Positives = 109/454 (23%), Gaps = 91/454 (20%)
Query: 62 SGGDLPEPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARF 121
S +P+ L N C + L+ R Q + A
Sbjct: 200 SFNHMPKIRTLRLHSNHLY--------CDCHLAWLSDWLR----QRRTVGQFTLCMAPVH 247
Query: 122 LTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKYSFY-GGKVKDEYLRRSPICR 180
L G N + C P + S + CR
Sbjct: 248 LRGFNVADVQKKEYVCPAP-------------HSEPPSCNANSISCPSPCTCSNNIVDCR 294
Query: 181 SAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSP 240
+ + L N I + G+F L+++ + + + A
Sbjct: 295 GKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGL 354
Query: 241 APRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNI 300
+ ++ G S Q L+ + L L +N
Sbjct: 355 KSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNK 414
Query: 301 ISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDEL 360
+ T+ G F L ++ L L+ N
Sbjct: 415 LQTISKGLFAPLQSIQTLHLAQN------------------------------------- 437
Query: 361 PALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCC 420
CDCHL+WL + Q+ ++ S C+ P L + ++ + C
Sbjct: 438 -----------PFVCDCHLKWLADYLQDNPIETSG-ARCSSPRRLANKRISQIKSKKFRC 485
Query: 421 EGALELHTHHLIP------SLRQVVFQGDRLPFQC----SASYLGNDTRIRWYHNRAPVE 470
G+ + + + +G + + N V
Sbjct: 486 SGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVS 545
Query: 471 GDEQAG------ILLAESLIHDCTFITSELTLSH 498
E G L +L ++ E
Sbjct: 546 VLEATGIFKKLPNLRKINLSNNKIKEVREGAFDG 579
Score = 211 bits (532), Expect = 2e-53
Identities = 49/270 (18%), Positives = 90/270 (33%), Gaps = 17/270 (6%)
Query: 245 WRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTV 304
+ ++ + + +GL + L N I+ +
Sbjct: 311 EIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEI 370
Query: 305 QPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALK 364
G F GL L+ L L+ N+I CL TFQ L L L++ N ++ G+F L +++
Sbjct: 371 AKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQ 430
Query: 365 VVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGAL 424
+ L CDCHL+WL + Q+ ++ S C+ P L + ++ + C G+
Sbjct: 431 TLHLAQNPFVCDCHLKWLADYLQDNPIETSG-ARCSSPRRLANKRISQIKSKKFRCSGSE 489
Query: 425 ELHTHHLIP------SLRQVVFQGDRLPFQC----SASYLGNDTRIRWYHNRAPVEGDEQ 474
+ + + +G + + N V E
Sbjct: 490 DYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEA 549
Query: 475 AG------ILLAESLIHDCTFITSELTLSH 498
G L +L ++ E
Sbjct: 550 TGIFKKLPNLRKINLSNNKIKEVREGAFDG 579
Score = 162 bits (407), Expect = 1e-38
Identities = 36/284 (12%), Positives = 59/284 (20%), Gaps = 41/284 (14%)
Query: 41 GERPKGLSGGVPGPAR-RRVVCSGGD----LPEPPEPGLLPNGTVTLGN----------- 84
G +GLSG R + C D L L N T+
Sbjct: 598 GRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLST 657
Query: 85 -----RFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIF 139
C + L + R SG + FL C
Sbjct: 658 INLLSNPFNCNCHLAWLGKWLRKRRI----VSGNPRCQKPFFLKEIPIQDVAIQDFTC-- 711
Query: 140 PGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRL 199
G ++ S + + C +
Sbjct: 712 -------------DGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELY 758
Query: 200 LSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQ 259
L N +T + L L + + + + + + S L
Sbjct: 759 LEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVH 817
Query: 260 KNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
G S + + G L + L N +
Sbjct: 818 AFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHC 861
Score = 138 bits (345), Expect = 2e-31
Identities = 52/212 (24%), Positives = 79/212 (36%), Gaps = 23/212 (10%)
Query: 261 NQGGSSSQE--------AASGLMPSRRLQRGEVEGLCTCLCT---DLRNNIISTVQPGAF 309
N+G + + R L DL NN IS + F
Sbjct: 740 NKGLRALPRGMPKDVTELYLEGNHLTAVPRE----LSALRHLTLIDLSNNSISMLTNYTF 795
Query: 310 LGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLG 369
+ L L LS NR+ C+ F GL L L + GN SS+ G F++L +L + LG
Sbjct: 796 SNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALG 855
Query: 370 TEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALEL--- 426
T L CDC LRWL W + + C+ P + L + + C+G +++
Sbjct: 856 TNPLHCDCSLRWLSEWVKAGYKEPG-IARCSSPEPMADRLLLTTPTHRFQCKGPVDINIV 914
Query: 427 ---HTHHLIPSLRQVVFQGDRLPF-QCSASYL 454
+ P D + +C+ Y
Sbjct: 915 AKCNACLSSPCKNNGTCTQDPVELYRCACPYS 946
Score = 114 bits (284), Expect = 3e-24
Identities = 37/217 (17%), Positives = 61/217 (28%), Gaps = 33/217 (15%)
Query: 245 WRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTV 304
L+ ++ L + L N + +
Sbjct: 756 ELYLEGNHLTAV-PRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCI 814
Query: 305 QPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALK 364
AF GL L+ L L N I + +F L L L +
Sbjct: 815 PVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLAL-------------------- 854
Query: 365 VVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGAL 424
GT L CDC LRWL W + + C+ P + L + + C+G +
Sbjct: 855 ----GTNPLHCDCSLRWLSEWVKAGYKEPG-IARCSSPEPMADRLLLTTPTHRFQCKGPV 909
Query: 425 EL------HTHHLIPSLRQVVFQGDRLPF-QCSASYL 454
++ + P D + +C+ Y
Sbjct: 910 DINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYS 946
Score = 47.5 bits (112), Expect = 4e-04
Identities = 16/106 (15%), Positives = 30/106 (28%), Gaps = 9/106 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPG---LLPNGTVTLGNRFSTAPCPQSGLAQS 99
P G+ R + G D+ PE L + LG C L++
Sbjct: 814 IPVHAFNGLRSL--RVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEW 871
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSW 145
+ ++ A + + + R C P ++
Sbjct: 872 VKAGYKEPGIA----RCSSPEPMADRLLLTTPTHRFQCKGPVDINI 913
Score = 42.5 bits (99), Expect = 0.015
Identities = 4/77 (5%), Positives = 11/77 (14%), Gaps = 9/77 (11%)
Query: 434 SLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV-----EGDEQAGILLAESLI 484
+ + R +R + L L
Sbjct: 34 CPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLE 93
Query: 485 HDCTFITSELTLSHIGV 501
+ + +
Sbjct: 94 DNQVSVIERGAFQDLKQ 110
>gb|AAD44760.1|AF144629_1 (AF144629) SLIT3 [Mus musculus]
Length = 1523
Score = 380 bits (968), Expect = e-104
Identities = 74/492 (15%), Positives = 127/492 (25%), Gaps = 96/492 (19%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRF------ 86
E PKGL G+ ++ C + DL L N T+
Sbjct: 369 EIPKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFVPLQS 428
Query: 87 ----------STAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA + P + S A + R L S + +
Sbjct: 429 IQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGA----RCSSPRRLANKRISQIKSKKFR 484
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C R + K C + + ++
Sbjct: 485 CSGSEDYRNR---------FSSECFMDLVCPEKCRCEGTIVDCSNQKLARIPSHLPEYTT 535
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L++N I+ L G F L L K+ + + E + A A + + L
Sbjct: 536 DLRLNDNDISVLEATGIFKKLPNLRKINLSNNRIKEVREGAFDGAASVQELMLTGNQLET 595
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G S + + GL + L +N I+T+ PGAF L L
Sbjct: 596 MHGRMFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSL 655
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
++L +N C
Sbjct: 656 STINLLSN------------------------------------------------PFNC 667
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSL 435
+CH+ WL W + R + +S + C P L + + C+G E
Sbjct: 668 NCHMAWLGRWLRKRRI-VSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCP 726
Query: 436 RQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQAGILLAESLIHDC 487
Q + Y + + L L ++
Sbjct: 727 EQFTCVETVVRCSNRGLHALPKGMPKDVTELYLEGNHLTAVPKELSAFRQLTLIDLSNNS 786
Query: 488 TFITSELTLSHI 499
+ + T S++
Sbjct: 787 ISMLTNHTFSNM 798
Score = 349 bits (887), Expect = 5e-95
Identities = 61/368 (16%), Positives = 107/368 (28%), Gaps = 37/368 (10%)
Query: 145 WRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNK 204
++ A S K S C +E L N
Sbjct: 13 RARLALGLALASILSGPPAAACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNN 72
Query: 205 ITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGG 264
IT + F GL L L + + E+ A +K L + Q
Sbjct: 73 ITRITKMDFAGLKNLRVLHLEDNQVSIIERGAFQDLKQLERLRLNKNKLQVLPELLFQST 132
Query: 265 SSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNR 324
+ + R G+ L NN IS ++ GAF L +L+ L L+NN
Sbjct: 133 PKLTRLDLSENQIQGIPRKAFRGVTGVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNN 192
Query: 325 IGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLP 384
I + +F + +P ++ + L + L CDCHL WL
Sbjct: 193 ISRILVTSF------------------------NHMPKIRTLRLHSNHLYCDCHLAWLSD 228
Query: 385 WAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHT---HHLIPSLRQVVFQ 441
W + R + + TLC P L ++ +Q+ + C G + +
Sbjct: 229 WLRQRRT-IGQFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAPACNANSLSCPSACSCS 287
Query: 442 GDRLPFQCS--ASYLGNDTR--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITS 492
+ + + N + + ++ Q L + + +
Sbjct: 288 NNIVDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIA 347
Query: 493 ELTLSHIG 500
+
Sbjct: 348 PDAFQGLK 355
Score = 251 bits (635), Expect = 2e-65
Identities = 65/498 (13%), Positives = 116/498 (23%), Gaps = 108/498 (21%)
Query: 43 RPKGLSGGVPG-----PARRRVVC----SGGDLPEPPEPGLLPN--------------GT 79
P+ GV G + C + L + L N
Sbjct: 148 IPRKAFRGVTGVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKI 207
Query: 80 VTL---GNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
TL N C + L+ R Q + A L G + +
Sbjct: 208 RTLRLHSNHLY-CDCHLAWLSDWLR----QRRTIGQFTLCMAPVHLRGFSVADVQKKEYV 262
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C P A + CR +
Sbjct: 263 CP---------GPHSEAPACNANS---LSCPSACSCSNNIVDCRGKGLTEIPANLPEGIV 310
Query: 197 FRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMA 256
L N I + G+F L+++ + + + A + ++
Sbjct: 311 EIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEI 370
Query: 257 GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELK 316
G S Q L+ + L L +N + T+ G F+ L ++
Sbjct: 371 PKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFVPLQSIQ 430
Query: 317 RLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCD 376
L L+ N CD
Sbjct: 431 TLHLAQN------------------------------------------------PFVCD 442
Query: 377 CHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIP--- 433
CHL+WL + Q+ ++ S C+ P L + ++ + C G+ +
Sbjct: 443 CHLKWLADYLQDNPIETSG-ARCSSPRRLANKRISQIKSKKFRCSGSEDYRNRFSSECFM 501
Query: 434 ---SLRQVVFQGDRLPFQC----SASYLGNDTRIRWYHNRAPVEGDEQAG------ILLA 480
+ +G + + N + E G L
Sbjct: 502 DLVCPEKCRCEGTIVDCSNQKLARIPSHLPEYTTDLRLNDNDISVLEATGIFKKLPNLRK 561
Query: 481 ESLIHDCTFITSELTLSH 498
+L ++ E
Sbjct: 562 INLSNNRIKEVREGAFDG 579
Score = 212 bits (536), Expect = 9e-54
Identities = 48/263 (18%), Positives = 95/263 (35%), Gaps = 10/263 (3%)
Query: 246 RLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTV 304
+ +S+ + + ++ + ++ G +G + L N + T+
Sbjct: 537 LRLNDNDISVLEATGIFKKLPNLRKINLSNNRIKEVREGAFDGAASVQELMLTGNQLETM 596
Query: 305 QPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALK 364
F GL LK L L +N I C++++TF GL + L++ N +++ PG F L +L
Sbjct: 597 HGRMFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLS 656
Query: 365 VVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGAL 424
++L + C+CH+ WL W + R + +S + C P L + + C+G
Sbjct: 657 TINLLSNPFNCNCHMAWLGRWLRKRRI-VSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNE 715
Query: 425 ELHTHHLIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQAG 476
E Q + Y + +
Sbjct: 716 ESSCQLSPRCPEQFTCVETVVRCSNRGLHALPKGMPKDVTELYLEGNHLTAVPKELSAFR 775
Query: 477 ILLAESLIHDCTFITSELTLSHI 499
L L ++ + + T S++
Sbjct: 776 QLTLIDLSNNSISMLTNHTFSNM 798
Score = 166 bits (417), Expect = 7e-40
Identities = 45/311 (14%), Positives = 76/311 (23%), Gaps = 43/311 (13%)
Query: 43 RPKGLSGGVPG-----PARRRVVC----SGGDLPEPPEPGLLPN--------------GT 79
P+ GV G + C + L + L N
Sbjct: 148 IPRKAFRGVTGVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKI 207
Query: 80 VTL---GNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
TL N C + L+ R Q + A L G + +
Sbjct: 208 RTLRLHSNHLY-CDCHLAWLSDWLR----QRRTIGQFTLCMAPVHLRGFSVADVQKKEYV 262
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C P A + CR +
Sbjct: 263 CP---------GPHSEAPACNANS---LSCPSACSCSNNIVDCRGKGLTEIPANLPEGIV 310
Query: 197 FRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMA 256
L N I + G+F L+++ + + + A + ++
Sbjct: 311 EIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEI 370
Query: 257 GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELK 316
G S Q L+ + L L +N + T+ G F+ L ++
Sbjct: 371 PKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFVPLQSIQ 430
Query: 317 RLDLSNNRIGC 327
L L+ N C
Sbjct: 431 TLHLAQNPFVC 441
Score = 155 bits (388), Expect = 2e-36
Identities = 37/286 (12%), Positives = 62/286 (20%), Gaps = 45/286 (15%)
Query: 41 GERPKGLSGGVPGPAR-RRVVCSGGD----LPEPPEPGLLPNGTVTLGN----------- 84
G +GLSG R + C D L L N T+
Sbjct: 598 GRMFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLST 657
Query: 85 -----RFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIF 139
C + L + R SG + FL C
Sbjct: 658 INLLSNPFNCNCHMAWLGRWLRKRRI----VSGNPRCQKPFFLKEIPIQDVAIQDFTC-- 711
Query: 140 PGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRL 199
G ++ S + + C +
Sbjct: 712 -------------DGNEESSCQLSPRCPEQFTCVETVVRCSNRGLHALPKGMPKDVTELY 758
Query: 200 LSNNKITGLRNG--SFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAG 257
L N +T + +F L+L + + + + + + S L
Sbjct: 759 LEGNHLTAVPKELSAFRQLTL---IDLSNNSISMLTNHTFSNMSHLSTLILSYNRLRCIP 815
Query: 258 NQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIIST 303
G S + + G L + L N +
Sbjct: 816 VHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHC 861
Score = 137 bits (343), Expect = 3e-31
Identities = 50/208 (24%), Positives = 77/208 (36%), Gaps = 23/208 (11%)
Query: 261 NQGGSSS--------QEAASGLMPSRRLQRG--EVEGLCTCLCTDLRNNIISTVQPGAFL 310
N+G + E + + DL NN IS + F
Sbjct: 740 NRGLHALPKGMPKDVTELYLEGNHLTAVPKELSAFR---QLTLIDLSNNSISMLTNHTFS 796
Query: 311 GLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGT 370
+ L L LS NR+ C+ F GL L L + GN SS+ G F++L +L + LGT
Sbjct: 797 NMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGT 856
Query: 371 EFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALEL---- 426
L CDC LRWL W + + C+ P ++ L + + C+G +++
Sbjct: 857 NPLHCDCSLRWLSEWVKAGYKEPG-IARCSSPESMADRLLLTTPTHRFQCKGPVDINIVA 915
Query: 427 --HTHHLIPSLRQVVFQGDRL---PFQC 449
+ P D + C
Sbjct: 916 KCNACLSSPCKNNGTCSQDPVEQYRCTC 943
Score = 46.7 bits (110), Expect = 8e-04
Identities = 16/106 (15%), Positives = 30/106 (28%), Gaps = 9/106 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPG---LLPNGTVTLGNRFSTAPCPQSGLAQS 99
P G+ R + G D+ PE L + LG C L++
Sbjct: 814 IPVHAFNGLRSL--RVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEW 871
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSW 145
+ ++ A + + + R C P ++
Sbjct: 872 VKAGYKEPGIA----RCSSPESMADRLLLTTPTHRFQCKGPVDINI 913
Score = 43.6 bits (102), Expect = 0.007
Identities = 5/79 (6%), Positives = 11/79 (13%), Gaps = 9/79 (11%)
Query: 432 IPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV-----EGDEQAGILLAES 482
+ + R +R + L
Sbjct: 32 AACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLH 91
Query: 483 LIHDCTFITSELTLSHIGV 501
L + I +
Sbjct: 92 LEDNQVSIIERGAFQDLKQ 110
>gb|AAG36772.1|AF210320_1 (AF210320) Slit3 [Danio rerio]
Length = 1515
Score = 369 bits (938), Expect = e-101
Identities = 78/498 (15%), Positives = 128/498 (25%), Gaps = 97/498 (19%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PKGL G+ ++ C + DL L N T+
Sbjct: 360 EIPKGLFDGLVSLQLLLLNANKINCLRVNTFKDLQNLNLLSLYDNKLQTISKGLFAPLRA 419
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A R L S +
Sbjct: 420 IKTLHLAQNPFMCDCHLKWLADYLFDNPIETSGA----RCSHPRRLANKRISQVKGKKFR 475
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C R G + + C + +
Sbjct: 476 CTGAEDYRSRL---------SGECFQDLVCPERCRCEGTVVDCSNLKLTKIPPHLPEHTT 526
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L++N+I+ L G+F L L K+ + + + + A L L + L
Sbjct: 527 DLRLNDNEISILEATGAFKKLPNLRKINLSNNKLRDIREGAFDGAGGVLELLLTGNKLQS 586
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G + + GL + L +N IST+ PGAF L L
Sbjct: 587 VSGRMFKGLIGLKTLMLRSNQISCVDNATFTGLSSVRLLSLHDNRISTIAPGAFNTLHSL 646
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
++L +N C
Sbjct: 647 STINLLSN------------------------------------------------PYVC 658
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIP-S 434
DCHL WL W + + +S + C P+ L + + + C+GA E P
Sbjct: 659 DCHLAWLGLWLKKTRV-VSGNPRCQKPAFLKEIPIQDVAMPEFSCDGAEENVCLPSAPRC 717
Query: 435 LRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQAGILLAESLIHD 486
+ Y + + L L ++
Sbjct: 718 PESCTCSETVVRCSNRGLRSLPKAIPKDTTELYLEGNLLTSVPKELPNLKQLTLLDLSNN 777
Query: 487 CTFITSELTLSHIGVWAS 504
+ LT S++ A+
Sbjct: 778 SISHLAPLTFSNMTQLAT 795
Score = 357 bits (907), Expect = 2e-97
Identities = 63/352 (17%), Positives = 109/352 (30%), Gaps = 38/352 (10%)
Query: 162 SFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEK 221
+ G K C+ A +E L N IT + F GL L
Sbjct: 20 AVNGCPHKCSCSGSHVDCQGQAFKTVPRGIPRNAERLDLDRNNITRITKVDFSGLKNLRV 79
Query: 222 LLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQ 281
L + + E+ A ++ L + Q + + +
Sbjct: 80 LHLENNQISVIERGAFEGLKQLERIRLNRNRLQVLPELLFQSTTKLSRLDLSENQIQAVP 139
Query: 282 RGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLR 341
R G+ T L +N IS ++ GAF L +L+ L L+NN I + +F +P+L
Sbjct: 140 RKAFRGITTVKNLQLDSNHISCIEDGAFRALRDLEILTLNNNNITLIPLSSFNHMPKL-- 197
Query: 342 LNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAY 401
+ + L + L CDCHL WL W + R L+ T C
Sbjct: 198 ----------------------RTLRLHSNNLHCDCHLSWLSDWLRQRRG-LAPFTQCMA 234
Query: 402 PSALHAHALGSLQEAQLCCEGALELHTHHLIP----SLRQVVFQGDRLPFQCS--ASYLG 455
P+ + + +Q+ + C G +E P + + +
Sbjct: 235 PAHMRGLNVPDVQKREFVCTGPVETEPRSCAPQATICPAACTCNNNIVDCRRKGLTEIPA 294
Query: 456 NDTR--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIG 500
N + + ++ L L + +E S +
Sbjct: 295 NLPEGIVEIRLEQNMIKNIPAGAFSTYKKLKRIDLSKNQISEIAEDAFSGLR 346
Score = 356 bits (904), Expect = 7e-97
Identities = 63/351 (17%), Positives = 109/351 (30%), Gaps = 38/351 (10%)
Query: 162 SFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEK 221
+ G K C+ A +E L N IT + F GL L
Sbjct: 20 AVNGCPHKCSCSGSHVDCQGQAFKTVPRGIPRNAERLDLDRNNITRITKVDFSGLKNLRV 79
Query: 222 LLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQ 281
L + + E+ A ++ L + Q + + +
Sbjct: 80 LHLENNQISVIERGAFEGLKQLERIRLNRNRLQVLPELLFQSTTKLSRLDLSENQIQAVP 139
Query: 282 RGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLR 341
R G+ T L +N IS ++ GAF L +L+ L L+NN I + +F +P+L
Sbjct: 140 RKAFRGITTVKNLQLDSNHISCIEDGAFRALRDLEILTLNNNNITLIPLSSFNHMPKL-- 197
Query: 342 LNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAY 401
+ + L + L CDCHL WL W + R L+ T C
Sbjct: 198 ----------------------RTLRLHSNNLHCDCHLSWLSDWLRQRRG-LAPFTQCMA 234
Query: 402 PSALHAHALGSLQEAQLCCEGALELHTHHLIP----SLRQVVFQGDRLPFQCS--ASYLG 455
P+ + + +Q+ + C G +E P + + +
Sbjct: 235 PAHMRGLNVPDVQKREFVCTGPVETEPRSCAPQATICPAACTCNNNIVDCRRKGLTEIPA 294
Query: 456 NDTR--IRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHI 499
N + + ++ L L + +E S +
Sbjct: 295 NLPEGIVEIRLEQNMIKNIPAGAFSTYKKLKRIDLSKNQISEIAEDAFSGL 345
Score = 282 bits (716), Expect = 6e-75
Identities = 55/312 (17%), Positives = 87/312 (27%), Gaps = 39/312 (12%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
E PKGL G+ ++ C + DL L N T+
Sbjct: 360 EIPKGLFDGLVSLQLLLLNANKINCLRVNTFKDLQNLNLLSLYDNKLQTISKGLFAPLRA 419
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A R L S +
Sbjct: 420 IKTLHLAQNPFMCDCHLKWLADYLFDNPIETSGA----RCSHPRRLANKRISQVKGKKFR 475
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C R G + + C + +
Sbjct: 476 CTGAEDYRSRL---------SGECFQDLVCPERCRCEGTVVDCSNLKLTKIPPHLPEHTT 526
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L++N+I+ L G+F L L K+ + + + + A L L + L
Sbjct: 527 DLRLNDNEISILEATGAFKKLPNLRKINLSNNKLRDIREGAFDGAGGVLELLLTGNKLQS 586
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G + + GL + L +N IST+ PGAF L L
Sbjct: 587 VSGRMFKGLIGLKTLMLRSNQISCVDNATFTGLSSVRLLSLHDNRISTIAPGAFNTLHSL 646
Query: 316 KRLDLSNNRIGC 327
++L +N C
Sbjct: 647 STINLLSNPYVC 658
Score = 242 bits (613), Expect = 8e-63
Identities = 62/473 (13%), Positives = 112/473 (23%), Gaps = 87/473 (18%)
Query: 46 GLSGGVPGPARRRVVCSGGDLPEPPEPGL-LPNGTVTL---GNRFSTAPCPQSGLAQSFR 101
G + + ++ P TL N C S L+ R
Sbjct: 165 GAFRALRDLEIL--TLNNNNITLIPLSSFNHMPKLRTLRLHSNNL-HCDCHLSWLSDWLR 221
Query: 102 LCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKY 161
Q + + A + G N C P P A Q
Sbjct: 222 ----QRRGLAPFTQCMAPAHMRGLNVPDVQKREFVCTGP----VETEPRSCAPQ------ 267
Query: 162 SFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEK 221
CR + L N I + G+F L++
Sbjct: 268 -ATICPAACTCNNNIVDCRRKGLTEIPANLPEGIVEIRLEQNMIKNIPAGAFSTYKKLKR 326
Query: 222 LLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQ 281
+ + + E + A + ++ G S Q L+
Sbjct: 327 IDLSKNQISEIAEDAFSGLRSLTSLVLYGNKIAEIPKGLFDGLVSLQLLLLNANKINCLR 386
Query: 282 RGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLR 341
+ L L +N + T+ G F L +K L L+ N
Sbjct: 387 VNTFKDLQNLNLLSLYDNKLQTISKGLFAPLRAIKTLHLAQN------------------ 428
Query: 342 LNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAY 401
CDCHL+WL + + ++ S C++
Sbjct: 429 ------------------------------PFMCDCHLKWLADYLFDNPIETSG-ARCSH 457
Query: 402 PSALHAHALGSLQEAQLCCEGALELHTHHLIP------SLRQVVFQGDRLPFQC----SA 451
P L + ++ + C GA + + + +G +
Sbjct: 458 PRRLANKRISQVKGKKFRCTGAEDYRSRLSGECFQDLVCPERCRCEGTVVDCSNLKLTKI 517
Query: 452 SYLGNDTRIRWYHNRAPVE------GDEQAGILLAESLIHDCTFITSELTLSH 498
+ N + ++ L +L ++ E
Sbjct: 518 PPHLPEHTTDLRLNDNEISILEATGAFKKLPNLRKINLSNNKLRDIREGAFDG 570
Score = 209 bits (529), Expect = 6e-53
Identities = 55/269 (20%), Positives = 99/269 (36%), Gaps = 11/269 (4%)
Query: 246 RLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTV 304
+ +S+ + + ++ R ++ G +G L L N + +V
Sbjct: 528 LRLNDNEISILEATGAFKKLPNLRKINLSNNKLRDIREGAFDGAGGVLELLLTGNKLQSV 587
Query: 305 QPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALK 364
F GL LK L L +N+I C+ + TF GL + L++ N S++ PG F+ L +L
Sbjct: 588 SGRMFKGLIGLKTLMLRSNQISCVDNATFTGLSSVRLLSLHDNRISTIAPGAFNTLHSLS 647
Query: 365 VVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGAL 424
++L + CDCHL WL W + + +S + C P+ L + + + C+GA
Sbjct: 648 TINLLSNPYVCDCHLAWLGLWLKKTRV-VSGNPRCQKPAFLKEIPIQDVAMPEFSCDGAE 706
Query: 425 ELHTHHLIP-SLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQA 475
E P + Y + +
Sbjct: 707 ENVCLPSAPRCPESCTCSETVVRCSNRGLRSLPKAIPKDTTELYLEGNLLTSVPKELPNL 766
Query: 476 GILLAESLIHDCTFITSELTLSHIGVWAS 504
L L ++ + LT S++ A+
Sbjct: 767 KQLTLLDLSNNSISHLAPLTFSNMTQLAT 795
Score = 206 bits (519), Expect = 8e-52
Identities = 54/265 (20%), Positives = 97/265 (36%), Gaps = 11/265 (4%)
Query: 246 RLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTV 304
+ +S+ + + ++ R ++ G +G L L N + +V
Sbjct: 528 LRLNDNEISILEATGAFKKLPNLRKINLSNNKLRDIREGAFDGAGGVLELLLTGNKLQSV 587
Query: 305 QPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALK 364
F GL LK L L +N+I C+ + TF GL + L++ N S++ PG F+ L +L
Sbjct: 588 SGRMFKGLIGLKTLMLRSNQISCVDNATFTGLSSVRLLSLHDNRISTIAPGAFNTLHSLS 647
Query: 365 VVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGAL 424
++L + CDCHL WL W + + +S + C P+ L + + + C+GA
Sbjct: 648 TINLLSNPYVCDCHLAWLGLWLKKTRV-VSGNPRCQKPAFLKEIPIQDVAMPEFSCDGAE 706
Query: 425 ELHTHHLIP-SLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV----EGDEQA 475
E P + Y + +
Sbjct: 707 ENVCLPSAPRCPESCTCSETVVRCSNRGLRSLPKAIPKDTTELYLEGNLLTSVPKELPNL 766
Query: 476 GILLAESLIHDCTFITSELTLSHIG 500
L L ++ + LT S++
Sbjct: 767 KQLTLLDLSNNSISHLAPLTFSNMT 791
Score = 167 bits (421), Expect = 3e-40
Identities = 44/286 (15%), Positives = 71/286 (24%), Gaps = 22/286 (7%)
Query: 46 GLSGGVPGPARRRVVCSGGDLPEPPEPGL-LPNGTVTL---GNRFSTAPCPQSGLAQSFR 101
G + + ++ P TL N C S L+ R
Sbjct: 165 GAFRALRDLEIL--TLNNNNITLIPLSSFNHMPKLRTLRLHSNNL-HCDCHLSWLSDWLR 221
Query: 102 LCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKY 161
Q + + A + G N C P P A Q
Sbjct: 222 ----QRRGLAPFTQCMAPAHMRGLNVPDVQKREFVCTGP----VETEPRSCAPQ------ 267
Query: 162 SFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEK 221
CR + L N I + G+F L++
Sbjct: 268 -ATICPAACTCNNNIVDCRRKGLTEIPANLPEGIVEIRLEQNMIKNIPAGAFSTYKKLKR 326
Query: 222 LLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQ 281
+ + + E + A + ++ G S Q L+
Sbjct: 327 IDLSKNQISEIAEDAFSGLRSLTSLVLYGNKIAEIPKGLFDGLVSLQLLLLNANKINCLR 386
Query: 282 RGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGC 327
+ L L +N + T+ G F L +K L L+ N C
Sbjct: 387 VNTFKDLQNLNLLSLYDNKLQTISKGLFAPLRAIKTLHLAQNPFMC 432
Score = 156 bits (392), Expect = 7e-37
Identities = 34/281 (12%), Positives = 55/281 (19%), Gaps = 40/281 (14%)
Query: 40 SGERPKGLSGGVPGPAR-RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST------ 88
SG KGL G R ++ C + L L N T+
Sbjct: 588 SGRMFKGLIGLKTLMLRSNQISCVDNATFTGLSSVRLLSLHDNRISTIAPGAFNTLHSLS 647
Query: 89 ----------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACI 138
C + L + SG + FL +C
Sbjct: 648 TINLLSNPYVCDCHLAWLGLWLKKT----RVVSGNPRCQKPAFLKEIPIQDVAMPEFSCD 703
Query: 139 FPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFR 198
S C + + +
Sbjct: 704 GAEENVCLP--------------SAPRCPESCTCSETVVRCSNRGLRSLPKAIPKDTTEL 749
Query: 199 LLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGN 258
L N +T + L L L + + + + S +
Sbjct: 750 YLEGNLLTSVPKE-LPNLKQLTLLDLSNNSISHLAPLTFSNMTQLATLILSYNQIRCVPV 808
Query: 259 QKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN 299
G S + + G L + L N
Sbjct: 809 HAFDGLRSLRLLTLHGNDLSTVPEGAFNHLTSLSHLALGAN 849
Score = 141 bits (352), Expect = 3e-32
Identities = 51/191 (26%), Positives = 74/191 (38%), Gaps = 10/191 (5%)
Query: 261 NQGGSSS--------QEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGL 312
N+G S E + E+ L DL NN IS + P F +
Sbjct: 732 NRGLRSLPKAIPKDTTELYLEGNLLTSVP-KELPNLKQLTLLDLSNNSISHLAPLTFSNM 790
Query: 313 GELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEF 372
+L L LS N+I C+ F GL L L + GN S++ G F+ L +L + LG
Sbjct: 791 TQLATLILSYNQIRCVPVHAFDGLRSLRLLTLHGNDLSTVPEGAFNHLTSLSHLALGANP 850
Query: 373 LTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLI 432
L CDC LRWL W + + C P + L + + C+G +L+
Sbjct: 851 LYCDCELRWLSQWVKAGFKEPG-IARCTGPPDMADRLLLTTPLNRFQCKGPADLNLMSKC 909
Query: 433 PSLRQVVFQGD 443
Q +
Sbjct: 910 APCLATPCQNN 920
Score = 56.5 bits (135), Expect = 9e-07
Identities = 32/216 (14%), Positives = 48/216 (21%), Gaps = 44/216 (20%)
Query: 29 GCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPP--------EPGLLPNGTV 80
GCP C CSG V C G P L N
Sbjct: 23 GCPHK---CSCSGSH---------------VDCQGQAFKTVPRGIPRNAERLDLDRNNIT 64
Query: 81 TLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFP 140
+ + L A + L +
Sbjct: 65 RITKVDFSGLKNLRVLHLENNQISVIERGAFEGLKQLERIRLNRNRLQVLPELLFQSTTK 124
Query: 141 ---GPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTS---ARSW 194
+S Q+ A +G ++ S + A
Sbjct: 125 LSRLDLSENQIQAVPRKAFRGITTV------------KNLQLDSNHISCIEDGAFRALRD 172
Query: 195 SEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSD 230
E L+NN IT + SF + L L + ++
Sbjct: 173 LEILTLNNNNITLIPLSSFNHMPKLRTLRLHSNNLH 208
Score = 49.9 bits (118), Expect = 8e-05
Identities = 7/83 (8%), Positives = 17/83 (20%), Gaps = 9/83 (10%)
Query: 428 THHLIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPV-----EGDEQAGIL 478
+ + + G + Q A R +R + L
Sbjct: 18 SCAVNGCPHKCSCSGSHVDCQGQAFKTVPRGIPRNAERLDLDRNNITRITKVDFSGLKNL 77
Query: 479 LAESLIHDCTFITSELTLSHIGV 501
L ++ + +
Sbjct: 78 RVLHLENNQISVIERGAFEGLKQ 100
Score = 47.9 bits (113), Expect = 3e-04
Identities = 22/135 (16%), Positives = 35/135 (25%), Gaps = 12/135 (8%)
Query: 44 PKGLSGGVPGPARRRVVCSGGDLPEPPEP---GLLPNGTVTLGNRFSTAPCPQSGLAQSF 100
P G+ G DL PE L + LG C L+Q
Sbjct: 807 PVHAFDGLRSLRLL--TLHGNDLSTVPEGAFNHLTSLSHLALGANPLYCDCELRWLSQWV 864
Query: 101 RLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVS--WRQVPAYNAG-QDQ 157
+ ++ A + + R C P ++ + P Q+
Sbjct: 865 KAGFKEPGIA----RCTGPPDMADRLLLTTPLNRFQCKGPADLNLMSKCAPCLATPCQNN 920
Query: 158 GSKYSFYGGKVKDEY 172
G+ S G
Sbjct: 921 GTCVSDVTGSYHCTC 935
Score = 42.1 bits (98), Expect = 0.019
Identities = 27/183 (14%), Positives = 40/183 (21%), Gaps = 25/183 (13%)
Query: 28 PGCPLSIRSCKCS---------------GERPKGLSGGVPGPARRRVVCSGGDLPEPP-- 70
P P SC CS PK + + +LP
Sbjct: 712 PSAPRCPESCTCSETVVRCSNRGLRSLPKAIPKDTTEL--YLEGNLLTSVPKELPNLKQL 769
Query: 71 -EPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSA 129
L N L + + L S+ +A + S L G++ S
Sbjct: 770 TLLDLSNNSISHLAPLTFSNMTQLATLILSYNQIRCVPVHAFDGLRSLRLLTLHGNDLST 829
Query: 130 SDAGRPACIFPGPVSWRQV-PAYNAGQDQGSKYSFYGG---KVKDEYLRRSPICRSAAAL 185
G + P Y + + G P L
Sbjct: 830 VPEGAFNHLTSLSHLALGANPLYCDCELRWLSQWVKAGFKEPGIARCTGP-PDMADRLLL 888
Query: 186 HTD 188
T
Sbjct: 889 TTP 891
>gb|AAG28019.1|AF196976_1 (AF196976) NAG14 [Homo sapiens]
Length = 649
Score = 369 bits (938), Expect = e-101
Identities = 73/442 (16%), Positives = 132/442 (29%), Gaps = 73/442 (16%)
Query: 138 IFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLR--RSPICRSAAALHTDTSARSWS 195
+ P QV A + +C S +
Sbjct: 18 LLPFVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNT 77
Query: 196 EF------------------------------------------------RLLSNNKITG 207
+ L +N +T
Sbjct: 78 RYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTV 137
Query: 208 LRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLH-SKCTLSMAGNQKNQGGSS 266
+ +G+F LS L +L +R + + A + L +G +
Sbjct: 138 IPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFN 197
Query: 267 SQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIG 326
+ G+ + + + L ++ N ++PG+F GL LK+L + N+
Sbjct: 198 LKYLNLGMCNIKDMPN--LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSH-- 253
Query: 327 CLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWA 386
F GL L+ LN++ N SSL +F L L + L CDC + WL W
Sbjct: 254 --ERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWL 311
Query: 387 QNR-SLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRL 445
+ + C P + L + +A C + + +G
Sbjct: 312 REYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPF-----IMDAPRDLNISEGRMA 366
Query: 446 PFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASG 505
+C + ++W V A S+++D T L SH+ + +G
Sbjct: 367 ELKCRTP---PMSSVKWLLPNGTV--LSHASRHPRISVLNDGT-----LNFSHVLLSDTG 416
Query: 506 EWECTVSMAQGNASKKVEIVVL 527
+ C V+ GN++ + V
Sbjct: 417 VYTCMVTNVAGNSNASAYLNVS 438
Score = 104 bits (258), Expect = 3e-21
Identities = 43/291 (14%), Positives = 71/291 (23%), Gaps = 45/291 (15%)
Query: 15 WLL--LLLAPEARGAPGCPLSIRSCKCSG-------------ERPKGLSGGVPGPARRRV 59
W+L + A + G CP C CS E P+G+
Sbjct: 29 WILCAAIAAAASAGPQNCP---SVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMEN 85
Query: 60 VC------SGGDLPEPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGW 113
+ L L N + + L S A +
Sbjct: 86 NIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEY 145
Query: 114 VSSEAARFLTGHNWSASDAGRPACIFPGPVSW----RQVPAYNAGQDQGSKYSFYGGKVK 169
+S +L + + + + +++ + G +G Y
Sbjct: 146 LSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGM 205
Query: 170 DEYLRRSPICRSAAALHTDTSAR-SWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHF 228
E +S N +R GSF GLS L+KL +
Sbjct: 206 C------------NIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSH 253
Query: 229 SDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRR 279
E+ A A + + LS + E P
Sbjct: 254 ----ERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNC 300
Score = 84.1 bits (206), Expect = 5e-15
Identities = 15/104 (14%), Positives = 21/104 (19%), Gaps = 9/104 (8%)
Query: 41 GERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLGNRF----STAPCPQSGL 96
+ G+ + +L P L + C L
Sbjct: 251 NSHERNAFDGLASLVEL--NLAHNNLSSLPH-DLFTPLRYLVELHLHHNPWNCDCDILWL 307
Query: 97 AQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFP 140
A R S G A + G D C P
Sbjct: 308 AWWLREYIPTNSTCCG--RCHAPMHMRGRYLVEVDQASFQCSAP 349
>gb|AAD44758.1|AF144627_1 (AF144627) SLIT1 [Mus musculus]
Length = 1531
Score = 359 bits (914), Expect = 4e-98
Identities = 77/509 (15%), Positives = 127/509 (24%), Gaps = 96/509 (18%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P+G+ GG+ ++ C + DL L N +L T
Sbjct: 371 DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA R P + + A + R L + +
Sbjct: 431 IQTLHLAQNPFICDCNLKWLADFLRTNPIETTGA----RCASPRRLANKRIGQIKSKKFR 486
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C +P S K C S +
Sbjct: 487 CSAKEQYF---IPGTEDYHLNSECTSDVACPHKCRCEASVVECSSLKLSKIPERIPQSTT 543
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+I+ L G F LS L+K+ + + E E A + L
Sbjct: 544 ELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGAASVSELHLTANQLES 603
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G + + GL L +N I+T+ PGAF L L
Sbjct: 604 IRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQAL 663
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 664 STLNLLAN------------------------------------------------PFNC 675
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIP-S 434
+CHL WL W + R + ++ + C P L L + CE E P
Sbjct: 676 NCHLSWLGDWLRKRKI-VTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQC 734
Query: 435 LRQVVFQGDRLPFQCS----ASYLGNDTRIRWYHNRAPVE----GDEQAGILLAESLIHD 486
++ + Y + L L ++
Sbjct: 735 PQECACLDTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNN 794
Query: 487 CTFITSELTLSHIGVWAS-----GEWECT 510
S + +++ + +C
Sbjct: 795 KISSLSNSSFTNMSQLTTLILSYNALQCI 823
Score = 352 bits (895), Expect = 6e-96
Identities = 58/356 (16%), Positives = 100/356 (27%), Gaps = 39/356 (10%)
Query: 163 FYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKL 222
+ C + +E L+ N IT + F GL L L
Sbjct: 31 ATACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVL 90
Query: 223 LMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQR 282
+ + E+ A ++ L + Q + + + R
Sbjct: 91 QLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENFLQAVPR 150
Query: 283 GEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRL 342
G L N IS ++ GAF L L+ L L+NN I + +F
Sbjct: 151 KAFRGATDLKNLQLDKNRISCIEEGAFRALRGLEVLTLNNNNITTIPVSSF--------- 201
Query: 343 NISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYP 402
+ +P L+ L + L CDCHL WL W + R + T C+ P
Sbjct: 202 ---------------NHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPT-IGLFTQCSGP 245
Query: 403 SALHAHALGSLQEAQLCCEGALELH-----THHLIPSLRQVVFQGDRLPFQCSA----SY 453
++L + +Q+ + C G E T + +
Sbjct: 246 ASLRGLNVAEVQKGEFSCSGQGEAAGAPACTLSSGSCPAMCSCSSGIVDCRGKGLTAIPA 305
Query: 454 LGNDTRIRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+T ++ L L ++ + + S
Sbjct: 306 NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNS 361
Score = 282 bits (716), Expect = 7e-75
Identities = 57/312 (18%), Positives = 88/312 (27%), Gaps = 33/312 (10%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P+G+ GG+ ++ C + DL L N +L T
Sbjct: 371 DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA R P + + A + R L + +
Sbjct: 431 IQTLHLAQNPFICDCNLKWLADFLRTNPIETTGA----RCASPRRLANKRIGQIKSKKFR 486
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C +P S K C S +
Sbjct: 487 CSAKEQYF---IPGTEDYHLNSECTSDVACPHKCRCEASVVECSSLKLSKIPERIPQSTT 543
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+I+ L G F LS L+K+ + + E E A + L
Sbjct: 544 ELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGAASVSELHLTANQLES 603
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G + + GL L +N I+T+ PGAF L L
Sbjct: 604 IRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQAL 663
Query: 316 KRLDLSNNRIGC 327
L+L N C
Sbjct: 664 STLNLLANPFNC 675
Score = 242 bits (612), Expect = 9e-63
Identities = 57/482 (11%), Positives = 110/482 (21%), Gaps = 92/482 (19%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPGL-LPNGTVTL---GNRFSTAPCPQSGLAQ 98
+G + G + + ++ P T N C + L+Q
Sbjct: 172 IEEGAFRALRGL--EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLF-CDCHLAWLSQ 228
Query: 99 SFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQG 158
R P + L G N + G +C G A
Sbjct: 229 WLRQRP----TIGLFTQCSGPASLRGLNVAEVQKGEFSCSGQG----------EAAGAPA 274
Query: 159 SKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSL 218
S CR + L N I + G+F
Sbjct: 275 CTLSSGSCPAMCSCSSGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRK 334
Query: 219 LEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSR 278
L ++ + + E A + ++ G + Q
Sbjct: 335 LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN 394
Query: 279 RLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPR 338
++ + L L +N I ++ G F L ++ L L+ N
Sbjct: 395 CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN--------------- 439
Query: 339 LLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTL 398
CDC+L+WL + + ++ +
Sbjct: 440 ---------------------------------PFICDCNLKWLADFLRTNPIETTG-AR 465
Query: 399 CAYPSALHAHALGSLQEAQLCCEG------ALELHTHHLIP------SLRQVVFQGDRLP 446
CA P L +G ++ + C H + + +
Sbjct: 466 CASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVE 525
Query: 447 FQ----CSASYLGNDTRIRWYHNRAPVEG------DEQAGILLAESLIHDCTFITSELTL 496
+ N + ++ L +L ++ + T
Sbjct: 526 CSSLKLSKIPERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTF 585
Query: 497 SH 498
Sbjct: 586 EG 587
Score = 212 bits (536), Expect = 9e-54
Identities = 54/535 (10%), Positives = 107/535 (19%), Gaps = 130/535 (24%)
Query: 45 KGLSGGVPGPARRRVV---------CSGGDLPEPPEPGLLPNGTVTLGNRFSTAPCPQSG 95
+G + R R+ + L N + +
Sbjct: 102 RGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENFLQAVPRKAFRGATDLKN 161
Query: 96 LAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRP-------------------- 135
L A + L +N +
Sbjct: 162 LQLDKNRISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDC 221
Query: 136 -------------------ACIFPGPVSWRQVPAYNAGQD----QGSKYSFYG------- 165
C P + V G+ QG
Sbjct: 222 HLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKGEFSCSGQGEAAGAPACTLSSGS 281
Query: 166 GKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMR 225
CR + L N I + G+F L ++ +
Sbjct: 282 CPAMCSCSSGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLS 341
Query: 226 AHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEV 285
+ E A + ++ G + Q ++
Sbjct: 342 NNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAF 401
Query: 286 EGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNIS 345
+ L L +N I ++ G F L ++ L L+ N
Sbjct: 402 QDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---------------------- 439
Query: 346 GNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSAL 405
CDC+L+WL + + ++ + CA P L
Sbjct: 440 --------------------------PFICDCNLKWLADFLRTNPIETTG-ARCASPRRL 472
Query: 406 HAHALGSLQEAQLCCEG------ALELHTHHLIP------SLRQVVFQGDRLPFQ----C 449
+G ++ + C H + + +
Sbjct: 473 ANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVECSSLKLS 532
Query: 450 SASYLGNDTRIRWYHNRAPVEG------DEQAGILLAESLIHDCTFITSELTLSH 498
+ N + ++ L +L ++ + T
Sbjct: 533 KIPERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEG 587
Score = 206 bits (520), Expect = 6e-52
Identities = 53/285 (18%), Positives = 98/285 (33%), Gaps = 16/285 (5%)
Query: 241 APRLWRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN 299
+ +S+ + S ++ ++ G EG + L N
Sbjct: 540 QSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGAASVSELHLTAN 599
Query: 300 IISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDE 359
+ +++ G F GL L+ L L NNRI C+ +++F GL + L++ N +++ PG FD
Sbjct: 600 QLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDT 659
Query: 360 LPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLC 419
L AL ++L C+CHL WL W + R + ++ + C P L L +
Sbjct: 660 LQALSTLNLLANPFNCNCHLSWLGDWLRKRKI-VTGNPRCQNPDFLRQIPLQDVAFPDFR 718
Query: 420 CEGALELHTHHLIP-SLRQVVFQGDRLPFQCS----ASYLGNDTRIRWYHNRAPVE---- 470
CE E P ++ + Y +
Sbjct: 719 CEEGQEEVGCLPRPQCPQECACLDTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPG 778
Query: 471 GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS-----GEWECT 510
L L ++ S + +++ + +C
Sbjct: 779 QLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCI 823
Score = 153 bits (384), Expect = 6e-36
Identities = 51/339 (15%), Positives = 68/339 (20%), Gaps = 113/339 (33%)
Query: 23 EARGAPGCPLSIRSC--KCSG----------------------------------ERPKG 46
EA GAP C LS SC CS P G
Sbjct: 268 EAAGAPACTLSSGSCPAMCSCSSGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPG 327
Query: 47 LSGGVPGPARRRVVCS-----------GGDLPEPPEPGLLPNGTVTLGNR---------- 85
P RR+ S L L N L
Sbjct: 328 AFS--PYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQL 385
Query: 86 --------------FSTAPCPQSGLA--------------------QSFRL--CPEQYSN 109
S L+ Q+ L P
Sbjct: 386 LLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDC 445
Query: 110 ASGWV--------------SSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQ 155
W+ + R L + + C +P
Sbjct: 446 NLKWLADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCSAKEQYF---IPGTEDYH 502
Query: 156 DQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRN-GSFL 214
S K C S + L+NN+I+ L G F
Sbjct: 503 LNSECTSDVACPHKCRCEASVVECSSLKLSKIPERIPQSTTELRLNNNEISILEATGLFK 562
Query: 215 GLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTL 253
LS L+K+ + + E E A + L
Sbjct: 563 KLSHLKKINLSNNKVSEIEDGTFEGAASVSELHLTANQL 601
Score = 141 bits (354), Expect = 2e-32
Identities = 34/274 (12%), Positives = 59/274 (21%), Gaps = 44/274 (16%)
Query: 46 GLSGGVPG-----PARRRVVCSGGD----LPEPPEPGLLPNGTVTLGN------------ 84
G+ G+ G R+ C D L L N T+
Sbjct: 607 GMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTL 666
Query: 85 ----RFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFP 140
C S L R +G + FL C
Sbjct: 667 NLLANPFNCNCHLSWLGDWLRKRKI----VTGNPRCQNPDFLRQIPLQDVAFPDFRC--- 719
Query: 141 GPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLL 200
GQ++ + L C + L
Sbjct: 720 -----------EEGQEEVGCLPRPQCPQECACLDTVVRCSNKHLQALPKGIPKNVTELYL 768
Query: 201 SNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQK 260
N+ T + G L+ + + + ++ + + + S L
Sbjct: 769 DGNQFTLVP-GQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLA 827
Query: 261 NQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCT 294
Q S + + LQ G + +
Sbjct: 828 FQRLRSLRLLSLHGNDVSTLQEGIFADVTSLSHL 861
Score = 118 bits (293), Expect = 3e-25
Identities = 52/215 (24%), Positives = 78/215 (36%), Gaps = 16/215 (7%)
Query: 249 SKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGA 308
S L + + E + DL NN IS++ +
Sbjct: 748 SNKHLQALPKGIPK---NVTELYLDGNQFTLVPGQLSTF-KYLQLVDLSNNKISSLSNSS 803
Query: 309 FLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDL 368
F + +L L LS N + C+ FQ L L L++ GN S+LQ G+F ++ +L + +
Sbjct: 804 FTNMSQLTTLILSYNALQCIPPLAFQRLRSLRLLSLHGNDVSTLQEGIFADVTSLSHLAI 863
Query: 369 GTEFLTCDCHLRWLLPWAQNRSLQLSEH--TLCAYPSALHAHALGSLQEAQLCCEGALEL 426
G L CDC LRWL W + E CA P + L + + C+G L
Sbjct: 864 GANPLYCDCRLRWLSSWVK---TGYKEPGIARCAGPPEMEGKLLLTTPAKKFECQGPPSL 920
Query: 427 H------THHLIPSLRQVVFQGDRLPF-QCSASYL 454
P Q D L +C+
Sbjct: 921 AVQAKCDPCLSSPCQNQGTCHNDPLEVYRCTCPSG 955
Score = 35.1 bits (80), Expect = 2.8
Identities = 15/131 (11%), Positives = 34/131 (25%), Gaps = 23/131 (17%)
Query: 61 CSG-------------GDLPEPPEPGLLPN---GTVTLGNRFSTAPCPQSGLAQSFRLCP 104
+ D+ E + +G C L+ +
Sbjct: 826 LAFQRLRSLRLLSLHGNDVSTLQEGIFADVTSLSHLAIGANPLYCDCRLRWLSSWVKTGY 885
Query: 105 EQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFP--GPVSWRQVPAYNAG-QDQGSKY 161
++ A + G + A + C P V + P ++ Q+QG+ +
Sbjct: 886 KEPGIA----RCAGPPEMEGKLLLTTPAKKFECQGPPSLAVQAKCDPCLSSPCQNQGTCH 941
Query: 162 SFYGGKVKDEY 172
+ +
Sbjct: 942 NDPLEVYRCTC 952
>ref|NP_003052.1| slit (Drosophila) homolog 1; slit1 [Homo sapiens]
dbj|BAA35184.1| (AB017167) Slit-1 protein [Homo sapiens]
Length = 1534
Score = 359 bits (912), Expect = 6e-98
Identities = 79/509 (15%), Positives = 128/509 (24%), Gaps = 96/509 (18%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P+G+ GG+ ++ C + DL L N +L T
Sbjct: 371 DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA R P + S A + R L + +
Sbjct: 431 IQTLHLAQNPFICDCNLKWLADFLRTNPIETSGA----RCASPRRLANKRIGQIKSKKFR 486
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C +P Q S K C S +
Sbjct: 487 CSAKEQYF---IPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTA 543
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+I+ L G F L+ L+K+ + + E E A A + L
Sbjct: 544 ELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLES 603
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G + + GL L +N I+TV PGAF L L
Sbjct: 604 IRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSL 663
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 664 STLNLLAN------------------------------------------------PFNC 675
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIP-S 434
+C L WL W + R + ++ + C P L L + CE E P
Sbjct: 676 NCQLAWLGGWLRKRKI-VTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQC 734
Query: 435 LRQVVFQGDRLPFQCS----ASYLGNDTRIRWYHNRAPVE----GDEQAGILLAESLIHD 486
++ + Y + L L ++
Sbjct: 735 PQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNN 794
Query: 487 CTFITSELTLSHIGVWAS-----GEWECT 510
S + +++ + +C
Sbjct: 795 KISSLSNSSFTNMSQLTTLILSYNALQCI 823
Score = 356 bits (905), Expect = 5e-97
Identities = 59/356 (16%), Positives = 101/356 (27%), Gaps = 39/356 (10%)
Query: 163 FYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKL 222
+ C + +E L+ N IT + F GL L L
Sbjct: 31 ASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVL 90
Query: 223 LMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQR 282
+ + E+ A ++ L M Q + + + R
Sbjct: 91 QLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPR 150
Query: 283 GEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRL 342
G L N IS ++ GAF L L+ L L+NN I + +F
Sbjct: 151 KAFRGATDLKNLRLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSF--------- 201
Query: 343 NISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYP 402
+ +P L+ L + L CDCHL WL W + R + T C+ P
Sbjct: 202 ---------------NHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPT-IGLFTQCSGP 245
Query: 403 SALHAHALGSLQEAQLCCEGALELH-----THHLIPSLRQVVFQGDRLPFQCSA----SY 453
++L + +Q+++ C G E T + +
Sbjct: 246 ASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPA 305
Query: 454 LGNDTRIRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+T ++ L L ++ + + S
Sbjct: 306 NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNS 361
Score = 286 bits (725), Expect = 6e-76
Identities = 60/312 (19%), Positives = 90/312 (28%), Gaps = 33/312 (10%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P+G+ GG+ ++ C + DL L N +L T
Sbjct: 371 DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA R P + S A + R L + +
Sbjct: 431 IQTLHLAQNPFICDCNLKWLADFLRTNPIETSGA----RCASPRRLANKRIGQIKSKKFR 486
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C +P Q S K C S +
Sbjct: 487 CSAKEQYF---IPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTA 543
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+I+ L G F L+ L+K+ + + E E A A + L
Sbjct: 544 ELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLES 603
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G + + GL L +N I+TV PGAF L L
Sbjct: 604 IRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSL 663
Query: 316 KRLDLSNNRIGC 327
L+L N C
Sbjct: 664 STLNLLANPFNC 675
Score = 243 bits (616), Expect = 3e-63
Identities = 59/482 (12%), Positives = 113/482 (23%), Gaps = 92/482 (19%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPGL-LPNGTVTL---GNRFSTAPCPQSGLAQ 98
+G + G + + ++ P T N C + L+Q
Sbjct: 172 IEEGAFRALRGL--EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLF-CDCHLAWLSQ 228
Query: 99 SFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQG 158
R P + L G N + +C G AG+
Sbjct: 229 WLRQRP----TIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQG----------EAGRVPT 274
Query: 159 SKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSL 218
S CR + L N I + G+F
Sbjct: 275 CTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRK 334
Query: 219 LEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSR 278
L ++ + + E A + ++ G + Q
Sbjct: 335 LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN 394
Query: 279 RLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPR 338
++ + L L +N I ++ G F L ++ L L+ N
Sbjct: 395 CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN--------------- 439
Query: 339 LLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTL 398
CDC+L+WL + + ++ S
Sbjct: 440 ---------------------------------PFICDCNLKWLADFLRTNPIETSG-AR 465
Query: 399 CAYPSALHAHALGSLQEAQLCCEG-------ALELHTHHLI-----PSLRQVVFQGDRLP 446
CA P L +G ++ + C E + + + + + +
Sbjct: 466 CASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVE 525
Query: 447 FQ----CSASYLGNDTRIRWYHNRAPVEGDEQAG------ILLAESLIHDCTFITSELTL 496
+ N + E G L +L ++ +
Sbjct: 526 CSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAF 585
Query: 497 SH 498
Sbjct: 586 EG 587
Score = 198 bits (500), Expect = 2e-49
Identities = 49/269 (18%), Positives = 94/269 (34%), Gaps = 11/269 (4%)
Query: 241 APRLWRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN 299
+ +S+ + + ++ ++ G EG + L N
Sbjct: 540 QSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTAN 599
Query: 300 IISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDE 359
+ +++ G F GL L+ L L NNRI C+ +++F GL + L++ N +++ PG FD
Sbjct: 600 QLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDT 659
Query: 360 LPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLC 419
L +L ++L C+C L WL W + R + ++ + C P L L +
Sbjct: 660 LQSLSTLNLLANPFNCNCQLAWLGGWLRKRKI-VTGNPRCQNPDFLRQIPLQDVAFPDFR 718
Query: 420 CEGALELHTHHLIP-SLRQVVFQGDRLPFQCS----ASYLGNDTRIRWYHNRAPVE---- 470
CE E P ++ + Y +
Sbjct: 719 CEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPG 778
Query: 471 GDEQAGILLAESLIHDCTFITSELTLSHI 499
L L ++ S + +++
Sbjct: 779 QLSTFKYLQLVDLSNNKISSLSNSSFTNM 807
Score = 182 bits (459), Expect = 9e-45
Identities = 41/289 (14%), Positives = 73/289 (25%), Gaps = 21/289 (7%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPGL-LPNGTVTL---GNRFSTAPCPQSGLAQ 98
+G + G + + ++ P T N C + L+Q
Sbjct: 172 IEEGAFRALRGL--EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLF-CDCHLAWLSQ 228
Query: 99 SFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQG 158
R P + L G N + +C G AG+
Sbjct: 229 WLRQRP----TIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQG----------EAGRVPT 274
Query: 159 SKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSL 218
S CR + L N I + G+F
Sbjct: 275 CTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRK 334
Query: 219 LEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSR 278
L ++ + + E A + ++ G + Q
Sbjct: 335 LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN 394
Query: 279 RLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGC 327
++ + L L +N I ++ G F L ++ L L+ N C
Sbjct: 395 CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFIC 443
Score = 153 bits (385), Expect = 5e-36
Identities = 38/342 (11%), Positives = 69/342 (20%), Gaps = 59/342 (17%)
Query: 45 KGLSGGVPGPARRRVV---------CSGGDLPEPPEPGLLPNGTVTLGNRFSTAPCPQSG 95
+G + R R+ + L N + +
Sbjct: 102 RGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKN 161
Query: 96 LAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRP-------------------- 135
L A + L +N +
Sbjct: 162 LRLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDC 221
Query: 136 -------------------ACIFPGPVSWRQVPAY-----------NAGQDQGSKYSFYG 165
C P + V AG+ S
Sbjct: 222 HLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGS 281
Query: 166 GKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMR 225
CR + L N I + G+F L ++ +
Sbjct: 282 CPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLS 341
Query: 226 AHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEV 285
+ E A + ++ G + Q ++
Sbjct: 342 NNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAF 401
Query: 286 EGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGC 327
+ L L +N I ++ G F L ++ L L+ N C
Sbjct: 402 QDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFIC 443
Score = 145 bits (363), Expect = 2e-33
Identities = 50/339 (14%), Positives = 68/339 (19%), Gaps = 113/339 (33%)
Query: 23 EARGAPGCPLSIRS----CKCSG--------------------------------ERPKG 46
EA P C LS S C CS P G
Sbjct: 268 EAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPG 327
Query: 47 LSGGVPGPARRRVVCS-----------GGDLPEPPEPGLLPNGTVTLGNR---------- 85
P RR+ S L L N L
Sbjct: 328 AFS--PYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQL 385
Query: 86 --------------FSTAPCPQSGLA--------------------QSFRL--CPEQYSN 109
S L+ Q+ L P
Sbjct: 386 LLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDC 445
Query: 110 ASGWV--------------SSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQ 155
W+ + R L + + C +P Q
Sbjct: 446 NLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYF---IPGTEDYQ 502
Query: 156 DQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRN-GSFL 214
S K C S + L+NN+I+ L G F
Sbjct: 503 LNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFK 562
Query: 215 GLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTL 253
L+ L+K+ + + E E A A + L
Sbjct: 563 KLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQL 601
Score = 142 bits (357), Expect = 8e-33
Identities = 35/274 (12%), Positives = 61/274 (21%), Gaps = 44/274 (16%)
Query: 46 GLSGGVPG-----PARRRVVCSGGD----LPEPPEPGLLPNGTVTLGN------------ 84
G+ G+ G R+ C D L L N T+
Sbjct: 607 GMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTL 666
Query: 85 ----RFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFP 140
C + L R +G + FL C
Sbjct: 667 NLLANPFNCNCQLAWLGGWLRKRKI----VTGNPRCQNPDFLRQIPLQDVAFPDFRC--- 719
Query: 141 GPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLL 200
GQ++G + L C + L
Sbjct: 720 -----------EEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYL 768
Query: 201 SNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQK 260
N+ T + G L+ + + + ++ + + + S L
Sbjct: 769 DGNQFTLVP-GQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLA 827
Query: 261 NQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCT 294
QG S + + LQ G + +
Sbjct: 828 FQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHL 861
Score = 117 bits (292), Expect = 3e-25
Identities = 51/194 (26%), Positives = 75/194 (38%), Gaps = 13/194 (6%)
Query: 270 AASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLT 329
+ DL NN IS++ +F + +L L LS N + C+
Sbjct: 766 LYLDGNQFTLVPGQLSTF-KYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIP 824
Query: 330 SETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNR 389
FQGL L L++ GN S+LQ G+F ++ +L + +G L CDCHLRWL W +
Sbjct: 825 PLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK-- 882
Query: 390 SLQLSEH--TLCAYPSALHAHALGSLQEAQLCCEGALELH------THHLIPSLRQVVFQ 441
E CA P + L + + C+G L P Q
Sbjct: 883 -TGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCH 941
Query: 442 GDRLPF-QCSASYL 454
D L +C+
Sbjct: 942 NDPLEVYRCACPSG 955
Score = 38.6 bits (89), Expect = 0.22
Identities = 16/136 (11%), Positives = 39/136 (27%), Gaps = 12/136 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPN---GTVTLGNRFSTAPCPQSGLAQS 99
P G+ + G D+ E + +G C L+
Sbjct: 823 IPPLAFQGLRSLRLLSLH--GNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSW 880
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQ---VPAYNAGQD 156
+ ++ A + + G + A + C P ++ + + + Q+
Sbjct: 881 VKTGYKEPGIA----RCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQN 936
Query: 157 QGSKYSFYGGKVKDEY 172
QG+ ++ +
Sbjct: 937 QGTCHNDPLEVYRCAC 952
>pir||T42218 slit-1 protein homolog - rat
dbj|BAA32460.1| (AB011530) MEGF4 [Rattus norvegicus]
Length = 1531
Score = 356 bits (904), Expect = 6e-97
Identities = 74/509 (14%), Positives = 124/509 (23%), Gaps = 96/509 (18%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P+G+ GG+ ++ C + DL L N +L T
Sbjct: 371 DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA R P + + A + R L + +
Sbjct: 431 IQTLHLAQNPFICDCNLKWLADFLRTNPIETTGA----RCASPRRLANKRIGQIKSKKFR 486
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C +P S K C +
Sbjct: 487 CSAKEQYF---IPGTEDYHLNSECTSDVACPHKCRCEASVVECSGLKLSKIPERIPQSTT 543
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+I+ L G F LS L+K+ + + E E + L
Sbjct: 544 ELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLES 603
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G + + GL L +N I+T+ PGAF L L
Sbjct: 604 VRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQAL 663
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 664 STLNLLAN------------------------------------------------PFNC 675
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIP-S 434
+C L WL W + R + ++ + C P L L + CE E P
Sbjct: 676 NCQLAWLGDWLRKRKI-VTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQC 734
Query: 435 LRQVVFQGDRLPFQCS----ASYLGNDTRIRWYHNRAPVE----GDEQAGILLAESLIHD 486
++ + Y + L L ++
Sbjct: 735 PQECACLDTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNN 794
Query: 487 CTFITSELTLSHIGVWAS-----GEWECT 510
S + +++ + +C
Sbjct: 795 KISSLSNSSFTNMSQLTTLILSYNALQCI 823
Score = 356 bits (904), Expect = 6e-97
Identities = 57/356 (16%), Positives = 100/356 (28%), Gaps = 39/356 (10%)
Query: 163 FYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKL 222
+ C + +E L+ N IT + F GL L L
Sbjct: 31 ATACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVL 90
Query: 223 LMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQR 282
+ + E+ A ++ L + Q + + + R
Sbjct: 91 QLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENSLQAVPR 150
Query: 283 GEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRL 342
G L N IS ++ GAF L L+ L L+NN I + +F
Sbjct: 151 KAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSF--------- 201
Query: 343 NISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYP 402
+ +P L+ L + L CDCHL WL W + R + T C+ P
Sbjct: 202 ---------------NHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPT-IGLFTQCSGP 245
Query: 403 SALHAHALGSLQEAQLCCEGALELHT-----HHLIPSLRQVVFQGDRLPFQCSA----SY 453
++L + +Q+++ C G E + +
Sbjct: 246 ASLRGLNVAEVQKSEFSCSGQGEAAQVPACTLSSGSCPAMCSCSNGIVDCRGKGLTAIPA 305
Query: 454 LGNDTRIRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+T ++ L L ++ + + S
Sbjct: 306 NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNS 361
Score = 353 bits (898), Expect = 3e-96
Identities = 73/493 (14%), Positives = 121/493 (23%), Gaps = 91/493 (18%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P+G+ GG+ ++ C + DL L N +L T
Sbjct: 371 DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA R P + + A + R L + +
Sbjct: 431 IQTLHLAQNPFICDCNLKWLADFLRTNPIETTGA----RCASPRRLANKRIGQIKSKKFR 486
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C +P S K C +
Sbjct: 487 CSAKEQYF---IPGTEDYHLNSECTSDVACPHKCRCEASVVECSGLKLSKIPERIPQSTT 543
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+I+ L G F LS L+K+ + + E E + L
Sbjct: 544 ELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLES 603
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G + + GL L +N I+T+ PGAF L L
Sbjct: 604 VRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQAL 663
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 664 STLNLLAN------------------------------------------------PFNC 675
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIP-S 434
+C L WL W + R + ++ + C P L L + CE E P
Sbjct: 676 NCQLAWLGDWLRKRKI-VTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQC 734
Query: 435 LRQVVFQGDRLPFQCS----ASYLGNDTRIRWYHNRAPVE----GDEQAGILLAESLIHD 486
++ + Y + L L ++
Sbjct: 735 PQECACLDTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNN 794
Query: 487 CTFITSELTLSHI 499
S + +++
Sbjct: 795 KISSLSNSSFTNM 807
Score = 244 bits (618), Expect = 2e-63
Identities = 57/484 (11%), Positives = 110/484 (21%), Gaps = 92/484 (19%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPGL-LPNGTVTL---GNRFSTAPCPQSGLAQ 98
+G + G + + ++ P T N C + L+Q
Sbjct: 172 IEEGAFRALRGL--EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLF-CDCHLAWLSQ 228
Query: 99 SFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQG 158
R P + L G N + +C G A Q
Sbjct: 229 WLRQRP----TIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQG----------EAAQVPA 274
Query: 159 SKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSL 218
S CR + L N I + G+F
Sbjct: 275 CTLSSGSCPAMCSCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRK 334
Query: 219 LEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSR 278
L ++ + + E A + ++ G + Q
Sbjct: 335 LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN 394
Query: 279 RLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPR 338
++ + L L +N I ++ G F L ++ L L+ N
Sbjct: 395 CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN--------------- 439
Query: 339 LLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTL 398
CDC+L+WL + + ++ +
Sbjct: 440 ---------------------------------PFICDCNLKWLADFLRTNPIETTG-AR 465
Query: 399 CAYPSALHAHALGSLQEAQLCCEG------ALELHTHHLIP------SLRQVVFQGDRLP 446
CA P L +G ++ + C H + + +
Sbjct: 466 CASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVE 525
Query: 447 FQC----SASYLGNDTRIRWYHNRAPVEG------DEQAGILLAESLIHDCTFITSELTL 496
+ N + ++ L +L ++ + T
Sbjct: 526 CSGLKLSKIPERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTF 585
Query: 497 SHIG 500
Sbjct: 586 EGAT 589
Score = 215 bits (543), Expect = 1e-54
Identities = 54/537 (10%), Positives = 106/537 (19%), Gaps = 130/537 (24%)
Query: 45 KGLSGGVPGPARRRVV---------CSGGDLPEPPEPGLLPNGTVTLGNRFSTAPCPQSG 95
+G + R R+ + L N + +
Sbjct: 102 RGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENSLQAVPRKAFRGATDLKN 161
Query: 96 LAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRP-------------------- 135
L A + L +N +
Sbjct: 162 LQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDC 221
Query: 136 -------------------ACIFPGPVSWRQVPAY-----------NAGQDQGSKYSFYG 165
C P + V A Q S
Sbjct: 222 HLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAAQVPACTLSSGS 281
Query: 166 GKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMR 225
CR + L N I + G+F L ++ +
Sbjct: 282 CPAMCSCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLS 341
Query: 226 AHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEV 285
+ E A + ++ G + Q ++
Sbjct: 342 NNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAF 401
Query: 286 EGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNIS 345
+ L L +N I ++ G F L ++ L L+ N
Sbjct: 402 QDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---------------------- 439
Query: 346 GNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSAL 405
CDC+L+WL + + ++ + CA P L
Sbjct: 440 --------------------------PFICDCNLKWLADFLRTNPIETTG-ARCASPRRL 472
Query: 406 HAHALGSLQEAQLCCEG------ALELHTHHLIP------SLRQVVFQGDRLPFQC---- 449
+G ++ + C H + + +
Sbjct: 473 ANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVECSGLKLS 532
Query: 450 SASYLGNDTRIRWYHNRAPVEG------DEQAGILLAESLIHDCTFITSELTLSHIG 500
+ N + ++ L +L ++ + T
Sbjct: 533 KIPERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGAT 589
Score = 178 bits (448), Expect = 2e-43
Identities = 48/365 (13%), Positives = 68/365 (18%), Gaps = 113/365 (30%)
Query: 23 EARGAPGCPLSIRSC--KCSG----------------------------------ERPKG 46
EA P C LS SC CS P G
Sbjct: 268 EAAQVPACTLSSGSCPAMCSCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPG 327
Query: 47 LSGGVPGPARRRVVCS-----------GGDLPEPPEPGLLPNGTVTLGNR---------- 85
P RR+ S L L N L
Sbjct: 328 AFS--PYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQL 385
Query: 86 --------------FSTAPCPQSGLA--------------------QSFRL--CPEQYSN 109
S L+ Q+ L P
Sbjct: 386 LLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDC 445
Query: 110 ASGWV--------------SSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQ 155
W+ + R L + + C +P
Sbjct: 446 NLKWLADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCSAKEQYF---IPGTEDYH 502
Query: 156 DQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRN-GSFL 214
S K C + L+NN+I+ L G F
Sbjct: 503 LNSECTSDVACPHKCRCEASVVECSGLKLSKIPERIPQSTTELRLNNNEISILEATGLFK 562
Query: 215 GLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGL 274
LS L+K+ + + E E + L + +G +
Sbjct: 563 KLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLESVRSGMFRGLDGLRTLMLRN 622
Query: 275 MPSRR 279
Sbjct: 623 NRISC 627
Score = 139 bits (347), Expect = 1e-31
Identities = 34/274 (12%), Positives = 60/274 (21%), Gaps = 44/274 (16%)
Query: 46 GLSGGVPG-----PARRRVVCSGGD----LPEPPEPGLLPNGTVTLGN------------ 84
G+ G+ G R+ C D L L N T+
Sbjct: 607 GMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTL 666
Query: 85 ----RFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFP 140
C + L R +G + FL C
Sbjct: 667 NLLANPFNCNCQLAWLGDWLRKRKI----VTGNPRCQNPDFLRQIPLQDVAFPDFRC--- 719
Query: 141 GPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLL 200
GQ++ + L C + L
Sbjct: 720 -----------EEGQEEVGCLPRPQCPQECACLDTVVRCSNKHLQALPKGIPKNVTELYL 768
Query: 201 SNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQK 260
N+ T + G L+ + + + ++ + + + S L
Sbjct: 769 DGNQFTLVP-GQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLA 827
Query: 261 NQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCT 294
QG S + + LQ G + +
Sbjct: 828 FQGLRSLRLLSLHGNDVSTLQEGIFADVTSLSHL 861
Score = 120 bits (300), Expect = 4e-26
Identities = 54/215 (25%), Positives = 80/215 (37%), Gaps = 16/215 (7%)
Query: 249 SKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGA 308
S L + + E + DL NN IS++ +
Sbjct: 748 SNKHLQALPKGIPK---NVTELYLDGNQFTLVPGQLSTF-KYLQLVDLSNNKISSLSNSS 803
Query: 309 FLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDL 368
F + +L L LS N + C+ FQGL L L++ GN S+LQ G+F ++ +L + +
Sbjct: 804 FTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDVSTLQEGIFADVTSLSHLAI 863
Query: 369 GTEFLTCDCHLRWLLPWAQNRSLQLSEH--TLCAYPSALHAHALGSLQEAQLCCEGALEL 426
G L CDCHLRWL W + E CA P + L + + C+G L
Sbjct: 864 GANPLYCDCHLRWLSSWVK---TGYKEPGIARCAGPPEMEGKLLLTTPAKKFECQGPPSL 920
Query: 427 H------THHLIPSLRQVVFQGDRLPF-QCSASYL 454
P Q D L +C+
Sbjct: 921 AVQAKCDPCLSSPCQNQGTCHNDPLEVYRCTCPSG 955
Score = 38.6 bits (89), Expect = 0.21
Identities = 18/136 (13%), Positives = 38/136 (27%), Gaps = 12/136 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPN---GTVTLGNRFSTAPCPQSGLAQS 99
P G+ + G D+ E + +G C L+
Sbjct: 823 IPPLAFQGLRSLRLLSLH--GNDVSTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSW 880
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFP--GPVSWRQVPAYNAG-QD 156
+ ++ A + G + A + C P V + P ++ Q+
Sbjct: 881 VKTGYKEPGIA----RCAGPPEMEGKLLLTTPAKKFECQGPPSLAVQAKCDPCLSSPCQN 936
Query: 157 QGSKYSFYGGKVKDEY 172
QG+ ++ +
Sbjct: 937 QGTCHNDPLEVYRCTC 952
>gb|AAF58097.1| (AE003809) sli gene product [alt 1] [Drosophila melanogaster]
Length = 1504
Score = 354 bits (900), Expect = 2e-96
Identities = 59/351 (16%), Positives = 97/351 (26%), Gaps = 37/351 (10%)
Query: 166 GKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMR 225
+ C + E L N +T + F L+ L L +
Sbjct: 73 CPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLT 132
Query: 226 AHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEV 285
+ E+ + + L +S + R
Sbjct: 133 DNQIHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVF 192
Query: 286 EGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNIS 345
+G + L NN I+ + AF GL EL+ L L+NN + L F GL RL L
Sbjct: 193 KGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRAL--- 249
Query: 346 GNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSAL 405
L CDCHL WL + ++ +L+ +T C PS L
Sbjct: 250 ---------------------RLSDNPFACDCHLSWLSRFLRSA-TRLAPYTRCQSPSQL 287
Query: 406 HAHALGSLQEAQLCCEGALELHTHHLI---PSLRQVVFQGDRLPFQ----CSASYLGNDT 458
+ L + + C G E + + S D
Sbjct: 288 KGQNVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDD 347
Query: 459 RIRWYHNRAPV-----EGDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+ + + L L ++ + LS + +
Sbjct: 348 TTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTT 398
Score = 189 bits (476), Expect = 8e-47
Identities = 62/497 (12%), Positives = 112/497 (22%), Gaps = 80/497 (16%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P G+ G+ + C + DL L N +L N
Sbjct: 408 DLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKS 467
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A E+ + + + +
Sbjct: 468 IKTVHLAKNPFICDCNLRWLADYLHKNPIETSGA----RCESPKRMHRRRIESLREEKFK 523
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G + C +
Sbjct: 524 CS----------WDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTT 573
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
LL++N++ + + G F L L KL ++ + E A + + +
Sbjct: 574 ELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKE 633
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN------IISTVQPGAF 309
N+ G + + G E L + +L +N ++
Sbjct: 634 ISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFA---- 689
Query: 310 LGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLG 369
L++ L+ C + + L F LG
Sbjct: 690 ---EWLRKKSLNGGAARCGAPSKVRDVQ-----------IKDLPHSEFKCSSENSEGCLG 735
Query: 370 TE--FLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELH 427
+C C + QL E P+ L S + Q+ E
Sbjct: 736 DGYCPPSCTC----TGTVVRCSRNQLKEIPR-GIPAETSELYLESNEIEQIHYE-----R 785
Query: 428 THHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWY----HNRAPVEGDEQAGILLAESL 483
HL R + L SL
Sbjct: 786 IRHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSL 845
Query: 484 IHDCTFITSELTLSHIG 500
+ + E + +
Sbjct: 846 HGNRISMLPEGSFEDLK 862
Score = 187 bits (472), Expect = 3e-46
Identities = 38/284 (13%), Positives = 71/284 (24%), Gaps = 40/284 (14%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P G+ G+ + C + DL L N +L N
Sbjct: 408 DLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKS 467
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A E+ + + + +
Sbjct: 468 IKTVHLAKNPFICDCNLRWLADYLHKNPIETSGA----RCESPKRMHRRRIESLREEKFK 523
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G + C +
Sbjct: 524 CS----------WDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTT 573
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
LL++N++ + + G F L L KL ++ + E A + + +
Sbjct: 574 ELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKE 633
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN 299
N+ G + + G E L + +L +N
Sbjct: 634 ISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASN 677
Score = 184 bits (464), Expect = 2e-45
Identities = 45/356 (12%), Positives = 84/356 (22%), Gaps = 69/356 (19%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPE---PGLLPNGTVTLGNRFSTAPCPQSGLAQS 99
+ G+ + +L P GL + L + C S L++
Sbjct: 211 LDEHAFKGLVELEIL--TLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSRF 268
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGS 159
R + ++ L G N + C
Sbjct: 269 LRSATRLAP----YTRCQSPSQLKGQNVADLHDQEFKCSG------------LTEHAPME 312
Query: 160 KYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLL 219
+ CR + + + L N IT L SF L
Sbjct: 313 CGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRL 372
Query: 220 EKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRR 279
++ + + A + + + +G S Q
Sbjct: 373 RRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISC 432
Query: 280 LQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRL 339
+++ L + L +N I ++ G F + +K + L+ N
Sbjct: 433 IRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKN---------------- 476
Query: 340 LRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSE 395
CDC+LRWL + ++ S
Sbjct: 477 --------------------------------PFICDCNLRWLADYLHKNPIETSG 500
Score = 178 bits (448), Expect = 2e-43
Identities = 48/245 (19%), Positives = 87/245 (34%), Gaps = 11/245 (4%)
Query: 270 AASGLMPSRRL-QRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCL 328
R+ G L + +L+ N ++ ++P AF G ++ L L N+I +
Sbjct: 575 LLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEI 634
Query: 329 TSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQN 388
+++ F GL +L LN+ N S + PG F+ L +L ++L + C+CHL W W +
Sbjct: 635 SNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAEWLRK 694
Query: 389 RSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQ 448
+SL C PS + + L ++ C G +
Sbjct: 695 KSLN-GGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGDGYCPPSCTCTGTVVRCS 753
Query: 449 C----SASYLGNDTRIRWYHNRAPVEG-----DEQAGILLAESLIHDCTFITSELTLSHI 499
Y +E L L ++ I S T +++
Sbjct: 754 RNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANL 813
Query: 500 GVWAS 504
++
Sbjct: 814 TKLST 818
Score = 149 bits (375), Expect = 6e-35
Identities = 26/266 (9%), Positives = 52/266 (18%), Gaps = 39/266 (14%)
Query: 54 PARRRVVCSGGD----LPEPPEPGLLPNGT----------------VTLGNRFSTAPCPQ 93
++ L + L N + L + C
Sbjct: 626 LGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHL 685
Query: 94 SGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNA 153
+ A+ R G A + C
Sbjct: 686 AWFAEWLRKKSLN----GGAARCGAPSKVRDVQIKDLPHSEFKCS--------------- 726
Query: 154 GQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSF 213
++ C + + L +N+I +
Sbjct: 727 SENSEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERI 786
Query: 214 LGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASG 273
L L +L + + + + S L G ++ + +
Sbjct: 787 RHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLH 846
Query: 274 LMPSRRLQRGEVEGLCTCLCTDLRNN 299
L G E L + L +N
Sbjct: 847 GNRISMLPEGSFEDLKSLTHIALGSN 872
Score = 149 bits (375), Expect = 6e-35
Identities = 26/266 (9%), Positives = 52/266 (18%), Gaps = 39/266 (14%)
Query: 54 PARRRVVCSGGD----LPEPPEPGLLPNGT----------------VTLGNRFSTAPCPQ 93
++ L + L N + L + C
Sbjct: 626 LGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHL 685
Query: 94 SGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNA 153
+ A+ R G A + C
Sbjct: 686 AWFAEWLRKKSLN----GGAARCGAPSKVRDVQIKDLPHSEFKCS--------------- 726
Query: 154 GQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSF 213
++ C + + L +N+I +
Sbjct: 727 SENSEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERI 786
Query: 214 LGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASG 273
L L +L + + + + S L G ++ + +
Sbjct: 787 RHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLH 846
Query: 274 LMPSRRLQRGEVEGLCTCLCTDLRNN 299
L G E L + L +N
Sbjct: 847 GNRISMLPEGSFEDLKSLTHIALGSN 872
Score = 145 bits (363), Expect = 2e-33
Identities = 37/222 (16%), Positives = 61/222 (26%), Gaps = 34/222 (15%)
Query: 225 RAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGE 284
+ E + PA + ++ + S L
Sbjct: 753 SRNQLKEIPRGI---PAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYT 809
Query: 285 VEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNI 344
L + N + +Q A GL L+ L L NRI L +F+ L L + +
Sbjct: 810 FANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIAL 869
Query: 345 SGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSA 404
G+ L CDC L+W W + ++ CA P
Sbjct: 870 ------------------------GSNPLYCDCGLKWFSDWIKLDYVEPG-IARCAEPEQ 904
Query: 405 LHAHALGSLQEAQLCCEG------ALELHTHHLIPSLRQVVF 440
+ + S + C G + + P Q
Sbjct: 905 MKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQC 946
Score = 144 bits (360), Expect = 4e-33
Identities = 47/198 (23%), Positives = 74/198 (36%), Gaps = 10/198 (5%)
Query: 249 SKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGA 308
S+ L S E ++ + L + DL NN I+ +
Sbjct: 753 SRNQLKEIPRGIPAETS---ELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYT 809
Query: 309 FLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDL 368
F L +L L +S N++ CL GL L L++ GN S L G F++L +L + L
Sbjct: 810 FANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIAL 869
Query: 369 GTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEG------ 422
G+ L CDC L+W W + ++ CA P + + S + C G
Sbjct: 870 GSNPLYCDCGLKWFSDWIKLDYVEPG-IARCAEPEQMKDKLILSTPSSSFVCRGRVRNDI 928
Query: 423 ALELHTHHLIPSLRQVVF 440
+ + P Q
Sbjct: 929 LAKCNACFEQPCQNQAQC 946
Score = 48.7 bits (115), Expect = 2e-04
Identities = 21/201 (10%), Positives = 44/201 (21%), Gaps = 28/201 (13%)
Query: 19 LLAPEARGAPGCPLSIRSCKCSG----ERPKGLSGGVPGPARRRVVCS------GGDLPE 68
+ EAR C + + CS P+ +S V + + L +
Sbjct: 66 GVITEARCPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTK 125
Query: 69 PPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWS 128
L N T+ L + N +S ++ + +
Sbjct: 126 LRMLQLTDNQIHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVIT 185
Query: 129 ASDAGRPA---CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAAL 185
+ + Q+ + +G +
Sbjct: 186 TVGRRVFKGAQSLRSLQLDNNQITCLDEHAFKGLVELE------------ILTLNNNNLT 233
Query: 186 HTDTSA---RSWSEFRLLSNN 203
+ LS+N
Sbjct: 234 SLPHNIFGGLGRLRALRLSDN 254
Score = 41.7 bits (97), Expect = 0.028
Identities = 22/137 (16%), Positives = 34/137 (24%), Gaps = 17/137 (12%)
Query: 24 ARGAPGCPLSIRSCKCSG-----------ERPKGL--SGGVPGPARRRVVCSG----GDL 66
+ G G SC C+G E P+G+ + L
Sbjct: 730 SEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHL 789
Query: 67 PEPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHN 126
L N L N S L S+ +A +++ L G+
Sbjct: 790 RSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNR 849
Query: 127 WSASDAGRPACIFPGPV 143
S G +
Sbjct: 850 ISMLPEGSFEDLKSLTH 866
Score = 34.7 bits (79), Expect = 3.7
Identities = 6/77 (7%), Positives = 14/77 (17%), Gaps = 9/77 (11%)
Query: 432 IPSLRQVVFQGDRLPFQ----CSASYLGNDTRIRWYHNRAPV-----EGDEQAGILLAES 482
R G + S + R + ++ L
Sbjct: 71 ARCPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQ 130
Query: 483 LIHDCTFITSELTLSHI 499
L + + +
Sbjct: 131 LTDNQIHTIERNSFQDL 147
>dbj|BAA86560.1| (AB033072) KIAA1246 protein [Homo sapiens]
Length = 832
Score = 354 bits (899), Expect = 2e-96
Identities = 70/428 (16%), Positives = 125/428 (28%), Gaps = 39/428 (9%)
Query: 131 DAGRPACIFPGPVSWRQVPAYNAG--QDQGSKYSFYGGKVKDEYLRRSPI----CRSAAA 184
C +S + + G + S C S
Sbjct: 27 HPAGGRCCLAQALSDQTMETLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGL 86
Query: 185 LHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRL 244
L + L N I + F ++ L L + + + +
Sbjct: 87 LFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLR 146
Query: 245 WRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEV-EGLCTCLCTDLRNNIIST 303
L G +G + Q + + L T DL N +
Sbjct: 147 SLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHG 206
Query: 304 VQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPG-VFDELPA 362
+ + + L +L L +N + + TF L +L RL+++ N L P +F A
Sbjct: 207 LPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQA 266
Query: 363 LKV----------VDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGS 412
+ G L C+C L WL ++ L+ C P L
Sbjct: 267 SALTATPFAPPLSFSFGGNPLHCNCELLWLRRLERDDDLE-----TCGSPGGLKGRYFWH 321
Query: 413 LQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGD 472
++E + CE + + +V +G +C A I W + G+
Sbjct: 322 VREEEFVCE-----PPLITQHTHKLLVLEGQAATLKCKA-IGDPSPLIHWVAPDDRLVGN 375
Query: 473 EQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSAS 532
++ + T L + SG + C + A G A+ VE+ +++
Sbjct: 376 SS-----RTAVYDNGT-----LDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHL 425
Query: 533 YCPAERVA 540
R A
Sbjct: 426 SNSTSRTA 433
>gb|AAD26567.1|AF126540_1 (AF126540) slit protein [Drosophila melanogaster]
Length = 1504
Score = 353 bits (897), Expect = 4e-96
Identities = 59/351 (16%), Positives = 97/351 (26%), Gaps = 37/351 (10%)
Query: 166 GKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMR 225
+ C + E L N +T + F L+ L L +
Sbjct: 73 CPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLT 132
Query: 226 AHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEV 285
+ E+ + + L +S + R
Sbjct: 133 DNQIHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVF 192
Query: 286 EGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNIS 345
+G + L NN I+ + AF GL EL+ L L+NN + L F GL RL L
Sbjct: 193 KGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRAL--- 249
Query: 346 GNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSAL 405
L CDCHL WL + ++ +L+ +T C PS L
Sbjct: 250 ---------------------RLSDNPFACDCHLSWLSRFLRSA-TRLAPYTRCQSPSQL 287
Query: 406 HAHALGSLQEAQLCCEGALELHTHHLI---PSLRQVVFQGDRLPFQ----CSASYLGNDT 458
+ L + + C G E + + S D
Sbjct: 288 KGQNVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDD 347
Query: 459 RIRWYHNRAPV-----EGDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+ + + L L ++ + LS + +
Sbjct: 348 TTDVRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTT 398
Score = 189 bits (477), Expect = 7e-47
Identities = 62/497 (12%), Positives = 112/497 (22%), Gaps = 80/497 (16%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P G+ G+ + C + DL L N +L N
Sbjct: 408 DLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKS 467
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A E+ + + + +
Sbjct: 468 IKTVHLAKNPFICDCNLRWLADYLHKNPIETSGA----RCESPKRMHRRRIESLREEKFK 523
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G + C +
Sbjct: 524 CS----------WDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTT 573
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
LL++N++ + + G F L L KL ++ + E A + + +
Sbjct: 574 ELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKE 633
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN------IISTVQPGAF 309
N+ G + + G E L + +L +N ++
Sbjct: 634 ISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFA---- 689
Query: 310 LGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLG 369
L++ L+ C + + L F LG
Sbjct: 690 ---EWLRKKSLNGGAARCGAPSKVRDVQ-----------IKDLPHSEFKCSSENSEGCLG 735
Query: 370 TE--FLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELH 427
+C C + QL E P+ L S + Q+ E
Sbjct: 736 DGYCPPSCTC----TGTVVRCSRNQLKEIPR-GIPAETSELYLESNEIEQIHYE-----R 785
Query: 428 THHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWY----HNRAPVEGDEQAGILLAESL 483
HL R + L SL
Sbjct: 786 IRHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSL 845
Query: 484 IHDCTFITSELTLSHIG 500
+ + E + +
Sbjct: 846 HGNRISMLPEGSFEDLK 862
Score = 188 bits (473), Expect = 2e-46
Identities = 38/284 (13%), Positives = 71/284 (24%), Gaps = 40/284 (14%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P G+ G+ + C + DL L N +L N
Sbjct: 408 DLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKS 467
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A E+ + + + +
Sbjct: 468 IKTVHLAKNPFICDCNLRWLADYLHKNPIETSGA----RCESPKRMHRRRIESLREEKFK 523
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G + C +
Sbjct: 524 CS----------WDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTT 573
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
LL++N++ + + G F L L KL ++ + E A + + +
Sbjct: 574 ELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKE 633
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN 299
N+ G + + G E L + +L +N
Sbjct: 634 ISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASN 677
Score = 180 bits (454), Expect = 4e-44
Identities = 45/356 (12%), Positives = 84/356 (22%), Gaps = 69/356 (19%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPE---PGLLPNGTVTLGNRFSTAPCPQSGLAQS 99
+ G+ + +L P GL + L + C S L++
Sbjct: 211 LDEHAFKGLVELEIL--TLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSRF 268
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGS 159
R + ++ L G N + C
Sbjct: 269 LRSATRLAP----YTRCQSPSQLKGQNVADLHDQEFKCSG------------LTEHAPME 312
Query: 160 KYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLL 219
+ CR + + + L N IT L SF L
Sbjct: 313 CGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDDTTDVRLEQNFITELPPKSFSSFRRL 372
Query: 220 EKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRR 279
++ + + A + + + +G S Q
Sbjct: 373 RRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISC 432
Query: 280 LQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRL 339
+++ L + L +N I ++ G F + +K + L+ N
Sbjct: 433 IRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKN---------------- 476
Query: 340 LRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSE 395
CDC+LRWL + ++ S
Sbjct: 477 --------------------------------PFICDCNLRWLADYLHKNPIETSG 500
Score = 178 bits (448), Expect = 2e-43
Identities = 48/245 (19%), Positives = 87/245 (34%), Gaps = 11/245 (4%)
Query: 270 AASGLMPSRRL-QRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCL 328
R+ G L + +L+ N ++ ++P AF G ++ L L N+I +
Sbjct: 575 LLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEI 634
Query: 329 TSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQN 388
+++ F GL +L LN+ N S + PG F+ L +L ++L + C+CHL W W +
Sbjct: 635 SNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAEWLRK 694
Query: 389 RSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQ 448
+SL C PS + + L ++ C G +
Sbjct: 695 KSLN-GGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGDGYCPPSCTCTGTVVRCS 753
Query: 449 C----SASYLGNDTRIRWYHNRAPVEG-----DEQAGILLAESLIHDCTFITSELTLSHI 499
Y +E L L ++ I S T +++
Sbjct: 754 RNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANL 813
Query: 500 GVWAS 504
++
Sbjct: 814 TKLST 818
Score = 169 bits (425), Expect = 9e-41
Identities = 50/266 (18%), Positives = 81/266 (29%), Gaps = 16/266 (6%)
Query: 248 HSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPG 307
+ ++ + + R+ + GL L N I + G
Sbjct: 353 LEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSG 412
Query: 308 AFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVD 367
F GLG L+ L L+ N I C+ + F+ L L L++ N SL G FD + ++K V
Sbjct: 413 VFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVH 472
Query: 368 LGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCE-----G 422
L CDC+LRWL + ++ S C P +H + SL+E + C
Sbjct: 473 LAKNPFICDCNLRWLADYLHKNPIETSG-ARCESPKRMHRRRIESLREEKFKCSWDELRM 531
Query: 423 ALELHTHHLIPSLRQVVFQGDRLPFQCSA----SYLGNDTRIRWYHNRAPVEGDEQ---- 474
L +G + N +
Sbjct: 532 KLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSDGLF 591
Query: 475 --AGILLAESLIHDCTFITSELTLSH 498
L+ L +
Sbjct: 592 GRLPHLVKLELKRNQLTGIEPNAFEG 617
Score = 150 bits (376), Expect = 5e-35
Identities = 26/266 (9%), Positives = 52/266 (18%), Gaps = 39/266 (14%)
Query: 54 PARRRVVCSGGD----LPEPPEPGLLPNGT----------------VTLGNRFSTAPCPQ 93
++ L + L N + L + C
Sbjct: 626 LGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHL 685
Query: 94 SGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNA 153
+ A+ R G A + C
Sbjct: 686 AWFAEWLRKKSLN----GGAARCGAPSKVRDVQIKDLPHSEFKCS--------------- 726
Query: 154 GQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSF 213
++ C + + L +N+I +
Sbjct: 727 SENSEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERI 786
Query: 214 LGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASG 273
L L +L + + + + S L G ++ + +
Sbjct: 787 RHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLH 846
Query: 274 LMPSRRLQRGEVEGLCTCLCTDLRNN 299
L G E L + L +N
Sbjct: 847 GNRISMLPEGSFEDLKSLTHIALGSN 872
Score = 150 bits (376), Expect = 5e-35
Identities = 26/266 (9%), Positives = 52/266 (18%), Gaps = 39/266 (14%)
Query: 54 PARRRVVCSGGD----LPEPPEPGLLPNGT----------------VTLGNRFSTAPCPQ 93
++ L + L N + L + C
Sbjct: 626 LGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHL 685
Query: 94 SGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNA 153
+ A+ R G A + C
Sbjct: 686 AWFAEWLRKKSLN----GGAARCGAPSKVRDVQIKDLPHSEFKCS--------------- 726
Query: 154 GQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSF 213
++ C + + L +N+I +
Sbjct: 727 SENSEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERI 786
Query: 214 LGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASG 273
L L +L + + + + S L G ++ + +
Sbjct: 787 RHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLH 846
Query: 274 LMPSRRLQRGEVEGLCTCLCTDLRNN 299
L G E L + L +N
Sbjct: 847 GNRISMLPEGSFEDLKSLTHIALGSN 872
Score = 145 bits (364), Expect = 1e-33
Identities = 37/222 (16%), Positives = 61/222 (26%), Gaps = 34/222 (15%)
Query: 225 RAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGE 284
+ E + PA + ++ + S L
Sbjct: 753 SRNQLKEIPRGI---PAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYT 809
Query: 285 VEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNI 344
L + N + +Q A GL L+ L L NRI L +F+ L L + +
Sbjct: 810 FANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIAL 869
Query: 345 SGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSA 404
G+ L CDC L+W W + ++ CA P
Sbjct: 870 ------------------------GSNPLYCDCGLKWFSDWIKLDYVEPG-IARCAEPEQ 904
Query: 405 LHAHALGSLQEAQLCCEG------ALELHTHHLIPSLRQVVF 440
+ + S + C G + + P Q
Sbjct: 905 MKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQC 946
Score = 144 bits (360), Expect = 4e-33
Identities = 47/198 (23%), Positives = 74/198 (36%), Gaps = 10/198 (5%)
Query: 249 SKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGA 308
S+ L S E ++ + L + DL NN I+ +
Sbjct: 753 SRNQLKEIPRGIPAETS---ELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYT 809
Query: 309 FLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDL 368
F L +L L +S N++ CL GL L L++ GN S L G F++L +L + L
Sbjct: 810 FANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIAL 869
Query: 369 GTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEG------ 422
G+ L CDC L+W W + ++ CA P + + S + C G
Sbjct: 870 GSNPLYCDCGLKWFSDWIKLDYVEPG-IARCAEPEQMKDKLILSTPSSSFVCRGRVRNDI 928
Query: 423 ALELHTHHLIPSLRQVVF 440
+ + P Q
Sbjct: 929 LAKCNACFEQPCQNQAQC 946
Score = 48.7 bits (115), Expect = 2e-04
Identities = 21/201 (10%), Positives = 44/201 (21%), Gaps = 28/201 (13%)
Query: 19 LLAPEARGAPGCPLSIRSCKCSG----ERPKGLSGGVPGPARRRVVCS------GGDLPE 68
+ EAR C + + CS P+ +S V + + L +
Sbjct: 66 GVITEARCPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTK 125
Query: 69 PPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWS 128
L N T+ L + N +S ++ + +
Sbjct: 126 LRMLQLTDNQIHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVIT 185
Query: 129 ASDAGRPA---CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAAL 185
+ + Q+ + +G +
Sbjct: 186 TVGRRVFKGAQSLRSLQLDNNQITCLDEHAFKGLVELE------------ILTLNNNNLT 233
Query: 186 HTDTSA---RSWSEFRLLSNN 203
+ LS+N
Sbjct: 234 SLPHNIFGGLGRLRALRLSDN 254
Score = 41.7 bits (97), Expect = 0.028
Identities = 22/137 (16%), Positives = 34/137 (24%), Gaps = 17/137 (12%)
Query: 24 ARGAPGCPLSIRSCKCSG-----------ERPKGL--SGGVPGPARRRVVCSG----GDL 66
+ G G SC C+G E P+G+ + L
Sbjct: 730 SEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHL 789
Query: 67 PEPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHN 126
L N L N S L S+ +A +++ L G+
Sbjct: 790 RSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNR 849
Query: 127 WSASDAGRPACIFPGPV 143
S G +
Sbjct: 850 ISMLPEGSFEDLKSLTH 866
Score = 34.7 bits (79), Expect = 3.6
Identities = 6/77 (7%), Positives = 14/77 (17%), Gaps = 9/77 (11%)
Query: 432 IPSLRQVVFQGDRLPFQ----CSASYLGNDTRIRWYHNRAPV-----EGDEQAGILLAES 482
R G + S + R + ++ L
Sbjct: 71 ARCPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQ 130
Query: 483 LIHDCTFITSELTLSHI 499
L + + +
Sbjct: 131 LTDNQIHTIERNSFQDL 147
>gb|AAD25540.1|AF133730_1 (AF133730) Slit1 [Rattus norvegicus]
Length = 1530
Score = 352 bits (896), Expect = 6e-96
Identities = 58/356 (16%), Positives = 99/356 (27%), Gaps = 39/356 (10%)
Query: 163 FYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKL 222
+ C + +E L+ N IT + F GL L L
Sbjct: 31 ATACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITWIHKNDFAGLKQLRVL 90
Query: 223 LMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQR 282
+ + E A ++ L M Q + + + R
Sbjct: 91 QLMENPIGAVEPGAFDDMKELEPFQLNRNQLQMLPELLFQNNQALSRLDLSENSLQAVPR 150
Query: 283 GEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRL 342
G L N IS ++ GAF L L+ L L+NN I + +F
Sbjct: 151 KAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSF--------- 201
Query: 343 NISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYP 402
+ +P L+ L + L CDCHL WL W + R + T C+ P
Sbjct: 202 ---------------NHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPT-IGLFTQCSGP 245
Query: 403 SALHAHALGSLQEAQLCCEGALELHT-----HHLIPSLRQVVFQGDRLPFQCSA----SY 453
++L + +Q+++ C G E + +
Sbjct: 246 ASLRGLNVAEVQKSEFSCSGQGEAAQVPACTLSSGSCPAMCSCSNGIVDCRGKGLTAIPA 305
Query: 454 LGNDTRIRWYHNRAPVE-----GDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+T ++ L L ++ + + S
Sbjct: 306 NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNS 361
Score = 351 bits (892), Expect = 2e-95
Identities = 74/508 (14%), Positives = 123/508 (23%), Gaps = 95/508 (18%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P+G+ GG+ ++ C + DL L N +L T
Sbjct: 371 DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA R P + + A + R L + +
Sbjct: 431 IQTLHLAQNPFICDCNLKWLADFLRTNPIETTGA----RCASPRRLANKRIGQIKSKKFR 486
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C +P S K C +
Sbjct: 487 CSAKEQYF---IPGTEDYHLNSECTSDVACPHKCRCEASVVECSGLKLSKIPERIPQSTT 543
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+I+ L G F LS L+K+ + + E E + L
Sbjct: 544 ELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLES 603
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G + GL L +N I+T+ PGAF L L
Sbjct: 604 VRSGMFRGLDGLWSLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQAL 663
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 664 STLNLLAN------------------------------------------------PFNC 675
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIP-S 434
+C L WL W + R + ++ + C P L L + CE E P
Sbjct: 676 NCQLAWLGDWLRKRKI-VTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQC 734
Query: 435 LRQVVFQGDRLPFQCS---ASYLGNDTRIRWYHNRAPVE----GDEQAGILLAESLIHDC 487
++ + Y + L L ++
Sbjct: 735 PQECACLDTVVRCSNKHLQLLKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNK 794
Query: 488 TFITSELTLSHIGVWAS-----GEWECT 510
S + +++ + +C
Sbjct: 795 ISSLSNSSFTNMSQLTTLILSYNALQCI 822
Score = 348 bits (885), Expect = 1e-94
Identities = 73/492 (14%), Positives = 120/492 (23%), Gaps = 90/492 (18%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P+G+ GG+ ++ C + DL L N +L T
Sbjct: 371 DLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA R P + + A + R L + +
Sbjct: 431 IQTLHLAQNPFICDCNLKWLADFLRTNPIETTGA----RCASPRRLANKRIGQIKSKKFR 486
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C +P S K C +
Sbjct: 487 CSAKEQYF---IPGTEDYHLNSECTSDVACPHKCRCEASVVECSGLKLSKIPERIPQSTT 543
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
L+NN+I+ L G F LS L+K+ + + E E + L
Sbjct: 544 ELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLES 603
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGEL 315
+ +G + GL L +N I+T+ PGAF L L
Sbjct: 604 VRSGMFRGLDGLWSLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQAL 663
Query: 316 KRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTC 375
L+L N C
Sbjct: 664 STLNLLAN------------------------------------------------PFNC 675
Query: 376 DCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIP-S 434
+C L WL W + R + ++ + C P L L + CE E P
Sbjct: 676 NCQLAWLGDWLRKRKI-VTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQC 734
Query: 435 LRQVVFQGDRLPFQCS---ASYLGNDTRIRWYHNRAPVE----GDEQAGILLAESLIHDC 487
++ + Y + L L ++
Sbjct: 735 PQECACLDTVVRCSNKHLQLLKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNK 794
Query: 488 TFITSELTLSHI 499
S + +++
Sbjct: 795 ISSLSNSSFTNM 806
Score = 245 bits (619), Expect = 2e-63
Identities = 57/484 (11%), Positives = 110/484 (21%), Gaps = 92/484 (19%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPGL-LPNGTVTL---GNRFSTAPCPQSGLAQ 98
+G + G + + ++ P T N C + L+Q
Sbjct: 172 IEEGAFRALRGL--EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLF-CDCHLAWLSQ 228
Query: 99 SFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQG 158
R P + L G N + +C G A Q
Sbjct: 229 WLRQRP----TIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQG----------EAAQVPA 274
Query: 159 SKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSL 218
S CR + L N I + G+F
Sbjct: 275 CTLSSGSCPAMCSCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRK 334
Query: 219 LEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSR 278
L ++ + + E A + ++ G + Q
Sbjct: 335 LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN 394
Query: 279 RLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPR 338
++ + L L +N I ++ G F L ++ L L+ N
Sbjct: 395 CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN--------------- 439
Query: 339 LLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTL 398
CDC+L+WL + + ++ +
Sbjct: 440 ---------------------------------PFICDCNLKWLADFLRTNPIETTG-AR 465
Query: 399 CAYPSALHAHALGSLQEAQLCCEG------ALELHTHHLIP------SLRQVVFQGDRLP 446
CA P L +G ++ + C H + + +
Sbjct: 466 CASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVE 525
Query: 447 FQC----SASYLGNDTRIRWYHNRAPVEG------DEQAGILLAESLIHDCTFITSELTL 496
+ N + ++ L +L ++ + T
Sbjct: 526 CSGLKLSKIPERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTF 585
Query: 497 SHIG 500
Sbjct: 586 EGAT 589
Score = 214 bits (541), Expect = 2e-54
Identities = 51/510 (10%), Positives = 100/510 (19%), Gaps = 121/510 (23%)
Query: 63 GGDLPEPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFL 122
+ L N + + L A + L
Sbjct: 129 FQNNQALSRLDLSENSLQAVPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTL 188
Query: 123 TGHNWSASDAGRP---------------------------------------ACIFPGPV 143
+N + C P +
Sbjct: 189 NNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASL 248
Query: 144 SWRQVPAY-----------NAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSAR 192
V A Q S CR +
Sbjct: 249 RGLNVAEVQKSEFSCSGQGEAAQVPACTLSSGSCPAMCSCSNGIVDCRGKGLTAIPANLP 308
Query: 193 SWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCT 252
L N I + G+F L ++ + + E A +
Sbjct: 309 ETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNK 368
Query: 253 LSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGL 312
++ G + Q ++ + L L +N I ++ G F L
Sbjct: 369 ITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSL 428
Query: 313 GELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEF 372
++ L L+ N
Sbjct: 429 RAIQTLHLAQN------------------------------------------------P 440
Query: 373 LTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEG------ALEL 426
CDC+L+WL + + ++ + CA P L +G ++ + C
Sbjct: 441 FICDCNLKWLADFLRTNPIETTG-ARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTE 499
Query: 427 HTHHLIP------SLRQVVFQGDRLPFQC----SASYLGNDTRIRWYHNRAPVEG----- 471
H + + + + N +
Sbjct: 500 DYHLNSECTSDVACPHKCRCEASVVECSGLKLSKIPERIPQSTTELRLNNNEISILEATG 559
Query: 472 -DEQAGILLAESLIHDCTFITSELTLSHIG 500
++ L +L ++ + T
Sbjct: 560 LFKKLSHLKKINLSNNKVSEIEDGTFEGAT 589
Score = 151 bits (378), Expect = 3e-35
Identities = 47/339 (13%), Positives = 64/339 (18%), Gaps = 113/339 (33%)
Query: 23 EARGAPGCPLSIRSC--KCSG----------------------------------ERPKG 46
EA P C LS SC CS P G
Sbjct: 268 EAAQVPACTLSSGSCPAMCSCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPG 327
Query: 47 LSGGVPGPARRRVVCS-----------GGDLPEPPEPGLLPNGTVTLGNR---------- 85
P RR+ S L L N L
Sbjct: 328 AFS--PYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQL 385
Query: 86 --------------FSTAPCPQSGLA--------------------QSFRL--CPEQYSN 109
S L+ Q+ L P
Sbjct: 386 LLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDC 445
Query: 110 ASGWV--------------SSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQ 155
W+ + R L + + C +P
Sbjct: 446 NLKWLADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCSAKEQYF---IPGTEDYH 502
Query: 156 DQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRN-GSFL 214
S K C + L+NN+I+ L G F
Sbjct: 503 LNSECTSDVACPHKCRCEASVVECSGLKLSKIPERIPQSTTELRLNNNEISILEATGLFK 562
Query: 215 GLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTL 253
LS L+K+ + + E E + L
Sbjct: 563 KLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQL 601
Score = 129 bits (323), Expect = 8e-29
Identities = 34/274 (12%), Positives = 60/274 (21%), Gaps = 45/274 (16%)
Query: 46 GLSGGVPG-----PARRRVVCSGGD----LPEPPEPGLLPNGTVTLGN------------ 84
G+ G+ G R+ C D L L N T+
Sbjct: 607 GMFRGLDGLWSLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTL 666
Query: 85 ----RFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFP 140
C + L R +G + FL C
Sbjct: 667 NLLANPFNCNCQLAWLGDWLRKRKI----VTGNPRCQNPDFLRQIPLQDVAFPDFRC--- 719
Query: 141 GPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLL 200
GQ++ + L C + L
Sbjct: 720 -----------EEGQEEVGCLPRPQCPQECACLDTVVRCSNKHLQLL-KGIPKNVTELYL 767
Query: 201 SNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQK 260
N+ T + G L+ + + + ++ + + + S L
Sbjct: 768 DGNQFTLVP-GQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLA 826
Query: 261 NQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCT 294
QG S + + LQ G + +
Sbjct: 827 FQGLRSLRLLSLHGNDVSTLQEGIFADVTSLSHL 860
Score = 121 bits (302), Expect = 2e-26
Identities = 55/213 (25%), Positives = 81/213 (37%), Gaps = 14/213 (6%)
Query: 252 TLSMAGNQKNQGGS-SSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGAFL 310
S Q +G + E + DL NN IS++ +F
Sbjct: 746 RCSNKHLQLLKGIPKNVTELYLDGNQFTLVPGQLSTF-KYLQLVDLSNNKISSLSNSSFT 804
Query: 311 GLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGT 370
+ +L L LS N + C+ FQGL L L++ GN S+LQ G+F ++ +L + +G
Sbjct: 805 NMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDVSTLQEGIFADVTSLSHLAIGA 864
Query: 371 EFLTCDCHLRWLLPWAQNRSLQLSEH--TLCAYPSALHAHALGSLQEAQLCCEGALELH- 427
L CDCHLRWL W + E CA P + L + + C+G L
Sbjct: 865 NPLYCDCHLRWLSSWVK---TGYKEPGIARCAGPPEMEGKLLLTTPAKKFECQGPPSLAV 921
Query: 428 -----THHLIPSLRQVVFQGDRLPF-QCSASYL 454
P Q D L +C+
Sbjct: 922 QAKCDPCLSNPCQNQGTCHNDPLEVYRCTCPSG 954
Score = 39.0 bits (90), Expect = 0.15
Identities = 18/136 (13%), Positives = 37/136 (26%), Gaps = 12/136 (8%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPN---GTVTLGNRFSTAPCPQSGLAQS 99
P G+ + G D+ E + +G C L+
Sbjct: 822 IPPLAFQGLRSLRLLSLH--GNDVSTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSW 879
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFP--GPVSWRQVPAYNAG-QD 156
+ ++ A + G + A + C P V + P + Q+
Sbjct: 880 VKTGYKEPGIA----RCAGPPEMEGKLLLTTPAKKFECQGPPSLAVQAKCDPCLSNPCQN 935
Query: 157 QGSKYSFYGGKVKDEY 172
QG+ ++ +
Sbjct: 936 QGTCHNDPLEVYRCTC 951
>gb|AAF58098.1| (AE003809) sli gene product [alt 2] [Drosophila melanogaster]
Length = 1480
Score = 336 bits (853), Expect = 6e-91
Identities = 52/351 (14%), Positives = 92/351 (25%), Gaps = 61/351 (17%)
Query: 166 GKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMR 225
+ C + E L N +T + F L+ L L +
Sbjct: 73 CPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLT 132
Query: 226 AHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEV 285
+ E+ + S ++ G + +G S + L
Sbjct: 133 DNQIHTIERNSFQDLVSLERLDISNNVITTVGRRVFKGAQSLRSLQLDNNQITCLDEHAF 192
Query: 286 EGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNIS 345
+GL L NN ++++ F GLG L+ L LS+N
Sbjct: 193 KGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDN---------------------- 230
Query: 346 GNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSAL 405
CDCHL WL + ++ +L+ +T C PS L
Sbjct: 231 --------------------------PFACDCHLSWLSRFLRSA-TRLAPYTRCQSPSQL 263
Query: 406 HAHALGSLQEAQLCCEGALELHTHHLI---PSLRQVVFQGDRLPFQ----CSASYLGNDT 458
+ L + + C G E + + S D
Sbjct: 264 KGQNVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDD 323
Query: 459 RIRWYHNRAPV-----EGDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+ + + L L ++ + LS + +
Sbjct: 324 TTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTT 374
Score = 190 bits (478), Expect = 6e-47
Identities = 62/497 (12%), Positives = 112/497 (22%), Gaps = 80/497 (16%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P G+ G+ + C + DL L N +L N
Sbjct: 384 DLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKS 443
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A E+ + + + +
Sbjct: 444 IKTVHLAKNPFICDCNLRWLADYLHKNPIETSGA----RCESPKRMHRRRIESLREEKFK 499
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G + C +
Sbjct: 500 CS----------WDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTT 549
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
LL++N++ + + G F L L KL ++ + E A + + +
Sbjct: 550 ELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKE 609
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN------IISTVQPGAF 309
N+ G + + G E L + +L +N ++
Sbjct: 610 ISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFA---- 665
Query: 310 LGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLG 369
L++ L+ C + + L F LG
Sbjct: 666 ---EWLRKKSLNGGAARCGAPSKVRDVQ-----------IKDLPHSEFKCSSENSEGCLG 711
Query: 370 TE--FLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELH 427
+C C + QL E P+ L S + Q+ E
Sbjct: 712 DGYCPPSCTC----TGTVVRCSRNQLKEIPR-GIPAETSELYLESNEIEQIHYE-----R 761
Query: 428 THHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWY----HNRAPVEGDEQAGILLAESL 483
HL R + L SL
Sbjct: 762 IRHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSL 821
Query: 484 IHDCTFITSELTLSHIG 500
+ + E + +
Sbjct: 822 HGNRISMLPEGSFEDLK 838
Score = 188 bits (473), Expect = 2e-46
Identities = 38/284 (13%), Positives = 71/284 (24%), Gaps = 40/284 (14%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P G+ G+ + C + DL L N +L N
Sbjct: 384 DLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKS 443
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A E+ + + + +
Sbjct: 444 IKTVHLAKNPFICDCNLRWLADYLHKNPIETSGA----RCESPKRMHRRRIESLREEKFK 499
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G + C +
Sbjct: 500 CS----------WDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTT 549
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
LL++N++ + + G F L L KL ++ + E A + + +
Sbjct: 550 ELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKE 609
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN 299
N+ G + + G E L + +L +N
Sbjct: 610 ISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASN 653
Score = 185 bits (465), Expect = 2e-45
Identities = 45/356 (12%), Positives = 84/356 (22%), Gaps = 69/356 (19%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPE---PGLLPNGTVTLGNRFSTAPCPQSGLAQS 99
+ G+ + +L P GL + L + C S L++
Sbjct: 187 LDEHAFKGLVELEIL--TLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSRF 244
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGS 159
R + ++ L G N + C
Sbjct: 245 LRSATRLAP----YTRCQSPSQLKGQNVADLHDQEFKCSG------------LTEHAPME 288
Query: 160 KYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLL 219
+ CR + + + L N IT L SF L
Sbjct: 289 CGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRL 348
Query: 220 EKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRR 279
++ + + A + + + +G S Q
Sbjct: 349 RRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISC 408
Query: 280 LQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRL 339
+++ L + L +N I ++ G F + +K + L+ N
Sbjct: 409 IRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKN---------------- 452
Query: 340 LRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSE 395
CDC+LRWL + ++ S
Sbjct: 453 --------------------------------PFICDCNLRWLADYLHKNPIETSG 476
Score = 178 bits (449), Expect = 1e-43
Identities = 48/245 (19%), Positives = 87/245 (34%), Gaps = 11/245 (4%)
Query: 270 AASGLMPSRRL-QRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCL 328
R+ G L + +L+ N ++ ++P AF G ++ L L N+I +
Sbjct: 551 LLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEI 610
Query: 329 TSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQN 388
+++ F GL +L LN+ N S + PG F+ L +L ++L + C+CHL W W +
Sbjct: 611 SNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAEWLRK 670
Query: 389 RSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQ 448
+SL C PS + + L ++ C G +
Sbjct: 671 KSLN-GGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGDGYCPPSCTCTGTVVRCS 729
Query: 449 C----SASYLGNDTRIRWYHNRAPVEG-----DEQAGILLAESLIHDCTFITSELTLSHI 499
Y +E L L ++ I S T +++
Sbjct: 730 RNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANL 789
Query: 500 GVWAS 504
++
Sbjct: 790 TKLST 794
Score = 150 bits (376), Expect = 5e-35
Identities = 26/266 (9%), Positives = 52/266 (18%), Gaps = 39/266 (14%)
Query: 54 PARRRVVCSGGD----LPEPPEPGLLPNGT----------------VTLGNRFSTAPCPQ 93
++ L + L N + L + C
Sbjct: 602 LGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHL 661
Query: 94 SGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNA 153
+ A+ R G A + C
Sbjct: 662 AWFAEWLRKKSLN----GGAARCGAPSKVRDVQIKDLPHSEFKCS--------------- 702
Query: 154 GQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSF 213
++ C + + L +N+I +
Sbjct: 703 SENSEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERI 762
Query: 214 LGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASG 273
L L +L + + + + S L G ++ + +
Sbjct: 763 RHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLH 822
Query: 274 LMPSRRLQRGEVEGLCTCLCTDLRNN 299
L G E L + L +N
Sbjct: 823 GNRISMLPEGSFEDLKSLTHIALGSN 848
Score = 150 bits (376), Expect = 5e-35
Identities = 26/266 (9%), Positives = 52/266 (18%), Gaps = 39/266 (14%)
Query: 54 PARRRVVCSGGD----LPEPPEPGLLPNGT----------------VTLGNRFSTAPCPQ 93
++ L + L N + L + C
Sbjct: 602 LGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHL 661
Query: 94 SGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNA 153
+ A+ R G A + C
Sbjct: 662 AWFAEWLRKKSLN----GGAARCGAPSKVRDVQIKDLPHSEFKCS--------------- 702
Query: 154 GQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSF 213
++ C + + L +N+I +
Sbjct: 703 SENSEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERI 762
Query: 214 LGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASG 273
L L +L + + + + S L G ++ + +
Sbjct: 763 RHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLH 822
Query: 274 LMPSRRLQRGEVEGLCTCLCTDLRNN 299
L G E L + L +N
Sbjct: 823 GNRISMLPEGSFEDLKSLTHIALGSN 848
Score = 145 bits (364), Expect = 1e-33
Identities = 37/222 (16%), Positives = 61/222 (26%), Gaps = 34/222 (15%)
Query: 225 RAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGE 284
+ E + PA + ++ + S L
Sbjct: 729 SRNQLKEIPRGI---PAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYT 785
Query: 285 VEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNI 344
L + N + +Q A GL L+ L L NRI L +F+ L L + +
Sbjct: 786 FANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIAL 845
Query: 345 SGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSA 404
G+ L CDC L+W W + ++ CA P
Sbjct: 846 ------------------------GSNPLYCDCGLKWFSDWIKLDYVEPG-IARCAEPEQ 880
Query: 405 LHAHALGSLQEAQLCCEG------ALELHTHHLIPSLRQVVF 440
+ + S + C G + + P Q
Sbjct: 881 MKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQC 922
Score = 144 bits (361), Expect = 3e-33
Identities = 47/198 (23%), Positives = 74/198 (36%), Gaps = 10/198 (5%)
Query: 249 SKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPGA 308
S+ L S E ++ + L + DL NN I+ +
Sbjct: 729 SRNQLKEIPRGIPAETS---ELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYT 785
Query: 309 FLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDL 368
F L +L L +S N++ CL GL L L++ GN S L G F++L +L + L
Sbjct: 786 FANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIAL 845
Query: 369 GTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEG------ 422
G+ L CDC L+W W + ++ CA P + + S + C G
Sbjct: 846 GSNPLYCDCGLKWFSDWIKLDYVEPG-IARCAEPEQMKDKLILSTPSSSFVCRGRVRNDI 904
Query: 423 ALELHTHHLIPSLRQVVF 440
+ + P Q
Sbjct: 905 LAKCNACFEQPCQNQAQC 922
Score = 41.7 bits (97), Expect = 0.027
Identities = 22/137 (16%), Positives = 34/137 (24%), Gaps = 17/137 (12%)
Query: 24 ARGAPGCPLSIRSCKCSG-----------ERPKGL--SGGVPGPARRRVVCSG----GDL 66
+ G G SC C+G E P+G+ + L
Sbjct: 706 SEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHL 765
Query: 67 PEPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHN 126
L N L N S L S+ +A +++ L G+
Sbjct: 766 RSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNR 825
Query: 127 WSASDAGRPACIFPGPV 143
S G +
Sbjct: 826 ISMLPEGSFEDLKSLTH 842
Score = 35.8 bits (82), Expect = 1.3
Identities = 18/128 (14%), Positives = 31/128 (24%), Gaps = 10/128 (7%)
Query: 19 LLAPEARGAPGCPLSIRSCKCSG----ERPKGLSGGVPGPARRRVVCS------GGDLPE 68
+ EAR C + + CS P+ +S V + + L +
Sbjct: 66 GVITEARCPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTK 125
Query: 69 PPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWS 128
L N T+ L S + S + L + +
Sbjct: 126 LRMLQLTDNQIHTIERNSFQDLVSLERLDISNNVITTVGRRVFKGAQSLRSLQLDNNQIT 185
Query: 129 ASDAGRPA 136
D
Sbjct: 186 CLDEHAFK 193
Score = 34.7 bits (79), Expect = 3.5
Identities = 6/77 (7%), Positives = 14/77 (17%), Gaps = 9/77 (11%)
Query: 432 IPSLRQVVFQGDRLPFQ----CSASYLGNDTRIRWYHNRAPV-----EGDEQAGILLAES 482
R G + S + R + ++ L
Sbjct: 71 ARCPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQ 130
Query: 483 LIHDCTFITSELTLSHI 499
L + + +
Sbjct: 131 LTDNQIHTIERNSFQDL 147
>prf||1704200A slit gene [Drosophila sp.]
Length = 1480
Score = 335 bits (852), Expect = 8e-91
Identities = 52/351 (14%), Positives = 92/351 (25%), Gaps = 61/351 (17%)
Query: 166 GKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMR 225
+ C + E L N +T + F L+ L L +
Sbjct: 73 CPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLT 132
Query: 226 AHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEV 285
+ E+ + S ++ G + +G S + L
Sbjct: 133 DNQIHTIERNSFQDLVSLERLDISNNVITTVGRRVFKGAQSLRSLQLDNNQITCLDEHAF 192
Query: 286 EGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNIS 345
+GL L NN ++++ F GLG L+ L LS+N
Sbjct: 193 KGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDN---------------------- 230
Query: 346 GNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSAL 405
CDCHL WL + ++ +L+ +T C PS L
Sbjct: 231 --------------------------PFACDCHLSWLSRFLRSA-TRLAPYTRCQSPSQL 263
Query: 406 HAHALGSLQEAQLCCEGALELHTHHLI---PSLRQVVFQGDRLPFQ----CSASYLGNDT 458
+ L + + C G E + + S D
Sbjct: 264 KGQNVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDD 323
Query: 459 RIRWYHNRAPV-----EGDEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+ + + L L ++ + LS + +
Sbjct: 324 TTDVRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTT 374
Score = 186 bits (468), Expect = 8e-46
Identities = 38/284 (13%), Positives = 71/284 (24%), Gaps = 40/284 (14%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P G+ G+ + C + DL L N +L N
Sbjct: 384 DLPSGVFKGLGSLRLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKS 443
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A E+ + + + +
Sbjct: 444 MKTVHLAKNPFICDCNLRWLADYLHKNPIETSGA----RCESPKRMHRRRIESLREEKFK 499
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G + C +
Sbjct: 500 CE----------WGELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRRLKEIPRDIPLHTT 549
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
LL++N++ + + G F L L KL ++ + E A + + +
Sbjct: 550 ELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKE 609
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN 299
N+ G + + G E L + +L +N
Sbjct: 610 ISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASN 653
Score = 186 bits (468), Expect = 8e-46
Identities = 38/284 (13%), Positives = 71/284 (24%), Gaps = 40/284 (14%)
Query: 42 ERPKGLSGGVPGPAR-----RRVVC----SGGDLPEPPEPGLLPNGTVTLGNRFST---- 88
+ P G+ G+ + C + DL L N +L N
Sbjct: 384 DLPSGVFKGLGSLRLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKS 443
Query: 89 ------------APCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPA 136
C LA P + S A E+ + + + +
Sbjct: 444 MKTVHLAKNPFICDCNLRWLADYLHKNPIETSGA----RCESPKRMHRRRIESLREEKFK 499
Query: 137 CIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSE 196
C + G + C +
Sbjct: 500 CE----------WGELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRRLKEIPRDIPLHTT 549
Query: 197 FRLLSNNKITGLRN-GSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSM 255
LL++N++ + + G F L L KL ++ + E A + + +
Sbjct: 550 ELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKE 609
Query: 256 AGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNN 299
N+ G + + G E L + +L +N
Sbjct: 610 ISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASN 653
Score = 173 bits (436), Expect = 5e-42
Identities = 37/288 (12%), Positives = 73/288 (24%), Gaps = 21/288 (7%)
Query: 43 RPKGLSGGVPGPARRRVVCSGGDLPEPPE---PGLLPNGTVTLGNRFSTAPCPQSGLAQS 99
+ G+ + +L P GL + L + C S L++
Sbjct: 187 LDEHAFKGLVELEIL--TLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSRF 244
Query: 100 FRLCPEQYSNASGWVSSEAARFLTGHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGS 159
R + ++ L G N + C
Sbjct: 245 LRSATRLAP----YTRCQSPSQLKGQNVADLHDQEFKCSG------------LTEHAPME 288
Query: 160 KYSFYGGKVKDEYLRRSPICRSAAALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLL 219
+ CR + + + L N IT L SF L
Sbjct: 289 CGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDDTTDVRLEQNFITELPPKSFSSFRRL 348
Query: 220 EKLLMRAHFSDEDEKTACPSPAPRLWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSRR 279
++ + + A + + + +G S +
Sbjct: 349 RRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIFDLPSGVFKGLGSLRLLLLNANEISC 408
Query: 280 LQRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGC 327
+++ L + L +N I ++ G F + +K + L+ N C
Sbjct: 409 IRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSMKTVHLAKNPFIC 456
Score = 171 bits (431), Expect = 2e-41
Identities = 47/245 (19%), Positives = 86/245 (34%), Gaps = 11/245 (4%)
Query: 270 AASGLMPSRRL-QRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCL 328
R+ G L + +L+ N ++ ++P AF G ++ L L N+I +
Sbjct: 551 LLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEI 610
Query: 329 TSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQN 388
+++ F GL +L LN+ N S + PG F+ L +L ++L + C+CHL W +
Sbjct: 611 SNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAECVRK 670
Query: 389 RSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQ 448
+SL C PS + + L ++ C G +
Sbjct: 671 KSLN-GGAARCGAPSKVRDVDIKDLPHSEFKCSSENSEGCLGDGYCPPSCTCTGTVVACS 729
Query: 449 C----SASYLGNDTRIRWYHNRAPVEG-----DEQAGILLAESLIHDCTFITSELTLSHI 499
Y +E L L ++ I S T +++
Sbjct: 730 RNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANL 789
Query: 500 GVWAS 504
++
Sbjct: 790 TKLST 794
Score = 170 bits (428), Expect = 4e-41
Identities = 52/267 (19%), Positives = 83/267 (30%), Gaps = 18/267 (6%)
Query: 248 HSKCTLSMAGNQKNQGGSSSQEAASGLMPSRRLQRGEVEGLCTCLCTDLRNNIISTVQPG 307
+ ++ + + R+ + GL L N I + G
Sbjct: 329 LEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIFDLPSG 388
Query: 308 AFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVD 367
F GLG L+ L L+ N I C+ + F+ L L L++ N SL G FD + ++K V
Sbjct: 389 VFKGLGSLRLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSMKTVH 448
Query: 368 LGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELH 427
L CDC+LRWL + ++ S C P +H + SL+E + CE EL
Sbjct: 449 LAKNPFICDCNLRWLADYLHKNPIETSG-ARCESPKRMHRRRIESLREEKFKCE-WGELR 506
Query: 428 THHLIP------SLRQVVFQGDRLPFQCS----ASYLGNDTRIRWYHNRAPVEGDEQ--- 474
+G + N +
Sbjct: 507 MKLSGECRMDSDCPAMCHCEGTTVDCTGRRLKEIPRDIPLHTTELLLNDNELGRISSDGL 566
Query: 475 ---AGILLAESLIHDCTFITSELTLSH 498
L+ L +
Sbjct: 567 FGRLPHLVKLELKRNQLTGIEPNAFEG 593
Score = 169 bits (425), Expect = 1e-40
Identities = 47/240 (19%), Positives = 84/240 (34%), Gaps = 11/240 (4%)
Query: 270 AASGLMPSRRL-QRGEVEGLCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCL 328
R+ G L + +L+ N ++ ++P AF G ++ L L N+I +
Sbjct: 551 LLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEI 610
Query: 329 TSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQN 388
+++ F GL +L LN+ N S + PG F+ L +L ++L + C+CHL W +
Sbjct: 611 SNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAECVRK 670
Query: 389 RSLQLSEHTLCAYPSALHAHALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQ 448
+SL C PS + + L ++ C G +
Sbjct: 671 KSLN-GGAARCGAPSKVRDVDIKDLPHSEFKCSSENSEGCLGDGYCPPSCTCTGTVVACS 729
Query: 449 C----SASYLGNDTRIRWYHNRAPVEG-----DEQAGILLAESLIHDCTFITSELTLSHI 499
Y +E L L ++ I S T +++
Sbjct: 730 RNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANL 789
Score = 162 bits (407), Expect = 1e-38
Identities = 46/286 (16%), Positives = 78/286 (27%), Gaps = 38/286 (13%)
Query: 229 SDEDEKTACPSPAPRLWRLHSKCTLSMA-GNQKNQGGSSSQEAASGLMPSRRLQRGEVEG 287
E + P L + L + + ++ EG
Sbjct: 537 LKEIPRDI---PLHTTELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEG 593
Query: 288 LCTCLCTDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGN 347
L N I + FLGL +LK L+L +N+I C+ +F+ L L LN++ N
Sbjct: 594 ASHIQELQLGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASN 653
Query: 348 IFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHA 407
C+CHL W + +SL C PS +
Sbjct: 654 ------------------------PFNCNCHLAWFAECVRKKSLN-GGAARCGAPSKVRD 688
Query: 408 HALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQC----SASYLGNDTRIRWY 463
+ L ++ C G + Y
Sbjct: 689 VDIKDLPHSEFKCSSENSEGCLGDGYCPPSCTCTGTVVACSRNQLKEIPRGIPAETSELY 748
Query: 464 HNRAPVEG-----DEQAGILLAESLIHDCTFITSELTLSHIGVWAS 504
+E L L ++ I S T +++ ++
Sbjct: 749 LESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANLTKLST 794
>sp|O93233|PLIB_AGKBL PHOSPHOLIPASE A2 INHIBITOR SUBUNIT B PRECURSOR (PLI-B)
dbj|BAA31994.1| (AB007198) phospholipase A2 inhibitor [Agkistrodon blomhoffii
siniticus]
Length = 331
Score = 81.0 bits (198), Expect = 4e-14
Identities = 27/215 (12%), Positives = 44/215 (19%), Gaps = 31/215 (14%)
Query: 64 GDLPEPPEPGLLPNGTVTLGNRFSTAPCPQSGLAQSFRLCPEQYSNASGWVSSEAARFLT 123
LP E L N TL + L S + SS L+
Sbjct: 76 QGLPNLQELHLSNNRLKTLPSGLFRNLPQLHTLDLSTNHLEDLPPEIFTNASSLILLPLS 135
Query: 124 GHNWSASDAGRPACIFPGPVSWRQVPAYNAGQDQGSKYSFYGGKVKDEYLRRSPICRSAA 183
+ + G + + + S +
Sbjct: 136 ENQLAELHPSWFQ--TLGELRILGLDHNQVKEIPISCFDKL-----------------KK 176
Query: 184 ALHTDTSARSWSEFRLLSNNKITGLRNGSFLGLSLLEKLLMRAHFSDEDEKTACPSPAPR 243
LS N + L F GL LEKL++ ++
Sbjct: 177 LTS-----------LDLSFNLLRRLAPEMFSGLDNLEKLILESNPIQCIVGRTFHWHPKL 225
Query: 244 LWRLHSKCTLSMAGNQKNQGGSSSQEAASGLMPSR 278
+L+ Q +
Sbjct: 226 TVLSLKNSSLTNI-MGFFQPLEQLELLDLSDNELT 259
CPU time: 118.24 user secs. 2.85 sys. secs 121.09 total secs.
Database: nr
Posted date: Dec 10, 2000 7:21 PM
Number of letters in database: 188,047,558
Number of sequences in database: 594,795
Lambda K H
0.310 0.160 0.449
Gapped
Lambda K H
0.270 0.0560 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 252553681
Number of Sequences: 594795
Number of extensions: 11893377
Number of successful extensions: 81923
Number of sequences better than 10.0: 3035
Number of HSP's better than 10.0 without gapping: 1704
Number of HSP's successfully gapped in prelim test: 1337
Number of HSP's that attempted gapping in prelim test: 37663
Number of HSP's gapped (non-prelim): 15498
length of query: 625
length of database: 188,047,558
effective HSP length: 53
effective length of query: 572
effective length of database: 156,523,423
effective search space: 89531397956
effective search space used: 89531397956
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.0 bits)
S2: 75 (33.4 bits)