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Table of Previously Characterized and Novel Tumor Endothelial Markers (TEMs) |
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The columns 1-7 have been derived from the SAGEnet Angiogenesis project. The entries referred to as "Description" are generated as part of the TEM @ IMP bioinformatics project.
46 tags with the highest tumor EC (T-ECs) to normal EC (N-ECs) tag ratios are listed in descending order. Please click on the TEM number for detailed information on the sequence analysis. Please note the difference in TEM numbering compared to Croix et al, who considered only a subset of nine TEMs in their paper. The chosen TEM enumeration is corresponding to the numbering found in the table. | ||||||||||||
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no. | Tag Sequence | N-ECs | T-ECs | HUVEC | HMVEC | Cell Lines | Description |
1 | GGGGCTGCCCA | 0 | 28 | 0 | 2 | 0 | Croix et al: TEM1: Receptor, internalization & potential ECM interacting |
2 | GATCTCCGTGT | 0 | 25 | 0 | 0 | 0 | Croix et al: TEM2: Rap subfamily member |
3 | CATTTTTATCT | 0 | 23 | 0 | 0 | 0 | Croix et al: TEM3, TEM7: Shares homology with two protein-families which have been implicated in axon migration. Sequence not confirmed, middle seq. part containing extracellular domains (PSI, NIDO) shared in homologues (Dros und C.el.) Potential type I TM protein |
4 | CTTTCTTTGAG | 0 | 22 | 6 | 20 | 1 | Dkk-3: thyroid binding colipase fold |
5 | TATTAACTCTC | 0 | 21 | 1 | 3 | 1 | Croix et al: TEM4: DH family Rho GEF potentially linking to MAPK patways |
6 | CAGGAGACCCC | 0 | 16 | 2 | 0 | 0 | MMP-11 Group II MMP, with a wide range of substrate specificity: weak activity against non-fibrillar collagen, LM, FN |
7 | GGAAATGTCAA | 1 | 31 | 53 | 22 | 1 | MMP-2 = type IV collagenase (Group III MMP): Gelatin, types IV, V and I collagen, LM, FN, proMMP-9,13 |
8 | CCTGGTTCAGT | 0 | 15 | 0 | 0 | 0 | HES family bHLH TF |
9 | TTTTTAAGAAC | 0 | 14 | 1 | 4 | 0 | Croix et al: TEM5: Secretin-like receptor with potential SH3 binding sites |
10 | TTTGGTTTTCC | 5 | 139 | 0 | 16 | 0 | COL1A2 major structural component of the ECM |
11 | ATTTTGTATGA | 0 | 13 | 4 | 8 | 0 | nidogen, was originally thought to stabilize the basement membrane by connnecting the laminin and collagen IV networks; recent studies show that nidogen 1 is not required for basement membrane formation or maintenance neither in mice nor in C.elegans. |
12 | ACTTTAGATGG | 1 | 23 | 0 | 15 | 0 | COL6A3 has a critical role in colVI assembly, colVI has both cell adhesion properties and a diverse range of ECM protein binding activities. |
13 | GAGTGAGACCC | 3 | 63 | 0 | 0 | 1 | Thy-1 is a marker of adult but not embryonic angiogenesis, the function of Thy-1 is unknown. |
14 | GTACACACACC | 0 | 10 | 0 | 0 | 0 | cystatin family member, cystein protease inhibitors |
15 | CCACAGGGGAT | 2 | 38 | 0 | 2 | 1 | col3A1 component of the basement membrane |
16 | TTAAAAGTCAC | 1 | 19 | 1 | 3 | 1 | Croix et al: TEM6: tensin-like, partial sequence |
17 | ACAGACTGTTA | 4 | 74 | 0 | 0 | 0 | Croix et al: TEM7: Shares homology with two protein-families which have been implicated in axon migration. Sequence not confirmed, middle seq. part containing extracellular domains (PSI, NIDO) shared in homologues (Dros und C.el.) Potential type I TM protein |
18 | CCACTGCAACC | 1 | 18 | 0 | 1 | 0 | protein sequence unknown |
19 | CTATAGGAGAC | 1 | 18 | 1 | 1 | 0 | Croix et al: TEM8: hypothetical, partial sequence hinting on a transmembrane or extracellular protein with relation to adhesion |
20 | GTTCCACAGAA | 0 | 9 | 0 | 3 | 0 | COL1A2 major structural component of the ECM |
21_1 | TACCACCTCCC | 0 | 9 | 4 | 1 | 1 | pregnancy specific beta-1-glycoprotein 1 |
21_2 | TACCACCTCCC | 0 | 9 | 4 | 1 | 1 | formin family member |
22 | GCCCTTTCTCT | 1 | 17 | 3 | 1 | 2 | Croix et al: TEM9: uPARAP, endocytic receptor interacting with uPAR and collagenV, potential role in ECM remodeling |
23 | TTAAATAGCAC | 2 | 33 | 0 | 4 | 0 | COL1A1 (Tem23, 38), two alpha 1(I) and one alpha 2(I) chains (Tem10,20,40) form a collagen I fiber |
24 | AGACATACTGA | 1 | 16 | 1 | 0 | 0 | human tensin, links cytoskeleton, plasma membrane and signaltransduction |
25 | TCCCCCAGGAG | 1 | 16 | 0 | 0 | 0 | BMP-1 is involved in the processing of several procollagens to collagens |
26 | AGCCCAAAGTG | 0 | 8 | 0 | 0 | 0 | Est sequence unknown |
27 | ACTACCATAAC | 0 | 8 | 0 | 0 | 0 | hSlit-3 (MEGF5) provide a matrix for the migration axons, link multiple ligands and thereby mediate cell interactions |
28 | TACAAATCGTT | 0 | 8 | 0 | 0 | 0 | nedrin related Rho-GAP with a potential role in the formation of macromolecular complexes |
29 | TTGGGTGAAAA | 0 | 8 | 0 | 0 | 0 | protein sequence unknown |
30 | CATTATCCAAA | 0 | 8 | 0 | 0 | 0 | Integrin alpha1, binds collagens I, collagen IV, laminin, regulates collagen synthesis, tumor vascularization was altered in the alpha1-null mice |
31_1 | AGAAACCACGG | 0 | 8 | 2 | 7 | 0 | collagen, type IV, alpha 1 |
31_2 | AGAAACCACGG | 0 | 8 | 2 | 7 | 0 | KIAA1164 |
32 | ACCAAAACCAC | 0 | 8 | 0 | 3 | 0 | Est sequence unknown |
33 | TGAAATAAAC | 0 | 8 | 3 | 1 | 1 | Est sequence unknown |
34 | TTTGGTTTCC | 1 | 15 | 0 | 0 | 0 | protein sequence unknown |
35 | GTGGAGACGGA | 1 | 15 | 1 | 2 | 1 | connexin 45, involved in vascular development |
36 | TTTGTGTTGTA | 1 | 14 | 2 | 0 | 0 | COL12A1, three a1(XII) chains compose Type XII collagens, non-fibrillar collagens termed FACIT(fibril-associated) provide specific molecular bridges between fibrils and other matrix components |
37 | TTATGTTTAAT | 3 | 39 | 0 | 0 | 1 | lumican, acts as a tissue organizers, orienting and ordering collagen fibrils |
38 | TGGAAATGACC | 15 | 179 | 0 | 40 | 0 | COL1A1 (Tem23, 38), Tem23 and Tem38 are potentially derived from the same transcript, with only Tem38 being obtained by classical tag derivation. |
39 | TGCCACACAGT | 1 | 13 | 0 | 2 | 0 | TGFbeta 3, potentially involved in ECM production |
40 | GATGAGGAGAC | 3 | 35 | 0 | 18 | 1 | COL2A1, the tag is localized in the proposed CDS and thus potentially results in a transcript differing from tem20, tem40 |
41 | ATCAAAGGTTT | 2 | 23 | 0 | 0 | 0 | olfactomedin-like, OLF domain is localized C-terminally in resemblance to secreted olfactomedin-related glycoproteins |
42 | AGTCACATAGT | 1 | 11 | 2 | 0 | 0 | RGS5 border-line reliability as the tag is unreliable: still considered due to the clear expression preference in aorta PolyA |
43 | TTCGGTTGGTC | 4 | 45 | 0 | 19 | 0 | no Unigen cluster matching the tag |
44 | CCCCACACGGG | 2 | 21 | 0 | 0 | 0 | unknown protein |
45 | GGCTTGCCTTT | 1 | 10 | 0 | 10 | 1 | Tropomyosin1 (alpha) |
46 | ATCCCTTCCCG | 1 | 10 | 1 | 0 | 0 | peanut-like protein 1 |