Score E
Sequences producing significant alignments: (bits) Value
ref|NP_055601.1| KIAA0337 gene product [Homo sapiens] >gi|2... 1881 0.0
ref|XP_012074.1| KIAA0337 gene product [Homo sapiens] 1403 0.0
gb|AAF55465.1| (AE003719) CG7397 gene product [Drosophila m... 291 2e-77
pir||T16657 hypothetical protein R02F2.3 - Caenorhabditis e... 171 4e-41
dbj|BAB12119.1| (AB047595) hypothetical protein [Macaca fas... 160 8e-38
dbj|BAB13452.1| (AB046846) KIAA1626 protein [Homo sapiens] 159 1e-37
ref|NP_055444.1| Rho guanine nucleotide exchange factor (GE... 158 3e-37
pir||T03307 hypothetical protein AAB71662.1 - human (fragme... 156 9e-37
gb|AAB60388.1| (U07000) breakpoint cluster region protein [... 135 2e-30
gb|AAA65939.1| (M24603) bcr [Homo sapiens] 134 6e-30
ref|NP_004318.2| breakpoint cluster region, isoform 1 [Homo... 134 6e-30
gb|AAB60390.1| (U07000) breakpoint cluster region protein [... 132 1e-29
gb|AAB60389.1| (U07000) breakpoint cluster region protein [... 132 2e-29
ref|NP_067585.1| breakpoint cluster region, isoform 2 [Homo... 131 5e-29
gb|AAB69637.1| (U82517) GrfA [Dictyostelium discoideum] 121 3e-26
gb|AAF48732.1| (AE003505) CG8557 gene product [Drosophila m... 118 2e-25
pir||T18289 racGAP protein - slime mold (Dictyostelium disc... 113 1e-23
pir||B47485 ABR protein 2 - human 110 6e-23
ref|NP_068781.1| active breakpoint cluster region-related ... 110 6e-23
ref|NP_001083.1| active breakpoint cluster region-related ... 109 1e-22
gb|AAA35594.1| (M15025) BCR-ABL protein [Homo sapiens] 109 2e-22
gb|AAF50508.1| (AE003557) pbl gene product [Drosophila mela... 108 3e-22
gb|AAD52845.1|AF136492_1 (AF136492) Pebble [Drosophila mela... 108 3e-22
ref|NP_031926.1| ect2 oncogene [Mus musculus] >gi|6015052|s... 108 4e-22
ref|NP_032027.1| faciogenital dysplasia homolog [Mus muscul... 105 3e-21
ref|XP_010215.1| faciogenital dysplasia protein [Homo sapiens] 104 5e-21
dbj|BAB14498.1| (AK023267) unnamed protein product [Homo sa... 104 6e-21
dbj|BAA92229.1| (AK000004) FLJ00004 protein [Homo sapiens] 102 1e-20
ref|NP_004454.1| faciogenital dysplasia protein [Homo sapie... 102 1e-20
ref|NP_056574.1| faciogenital dysplasia homolog 3 [Mus musc... 101 4e-20
pir||A59235 unconventional myosin heavy chain MyoM - slime ... 99 2e-19
pir||TVHUA2 bcr (breakpoint cluster region) protein, splice... 99 2e-19
dbj|BAA92600.1| (AB037783) KIAA1362 protein [Homo sapiens] 99 3e-19
gb|AAC27698.1| (AF038388) actin-filament binding protein Fr... 96 2e-18
gb|AAC35432.1| (AF017370) faciogenital dysplasia protein [D... 94 5e-18
ref|NP_036586.1| T-cell lymphoma invasion and metastasis 2 ... 94 9e-18
pir||T34566 hypothetical protein DKFZp434L1072.1 - human (f... 94 9e-18
emb|CAB62513.3| (AL035106) dJ998C11.1 (KIAA1415 protein (co... 93 1e-17
ref|XP_009741.2| intersectin 1 (SH3 domain protein) [Homo s... 93 1e-17
gb|AAD29952.1|AF114487_1 (AF114487) intersectin long isofor... 93 1e-17
gb|AAF50584.1| (AE003559) CG8606 gene product [Drosophila m... 93 2e-17
gb|AAF05901.1|AF120324_1 (AF120324) T-cell lymphoma invasio... 92 2e-17
ref|NP_003015.1| intersectin 1 (SH3 domain protein); inters... 92 2e-17
ref|NP_034717.1| intersectin (SH3 domain protein 1A); inter... 92 3e-17
ref|NP_036008.1| RAS-related C3 botulinum substrate 1, guan... 90 8e-17
ref|NP_006104.2| vav 3 oncogene [Homo sapiens] >gi|3928847|... 90 8e-17
sp|Q9UKW4|VAV3_HUMAN VAV-3 PROTEIN >gi|4416408|gb|AAD20349.... 90 1e-16
gb|AAD20348.1| (AF118886) VAV-3 protein beta isoform [Homo ... 90 1e-16
pir||T34428 hypothetical protein F55C7.7d - Caenorhabditis ... 89 2e-16
pir||T34426 hypothetical protein F55C7.7c - Caenorhabditis ... 89 2e-16
>ref|NP_055601.1| KIAA0337 gene product [Homo sapiens]
dbj|BAA20795.1| (AB002335) KIAA0337 [Homo sapiens]
Length = 1510
Score = 1881 bits (4820), Expect = 0.0
Identities = 933/933 (100%), Positives = 933/933 (100%)
Query: 1 MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGS 60
MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGS
Sbjct: 1 MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGS 60
Query: 61 DAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS 120
DAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS
Sbjct: 61 DAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS 120
Query: 121 SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSEFSNGEAGEAYRS 180
SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSEFSNGEAGEAYRS
Sbjct: 121 SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSEFSNGEAGEAYRS 180
Query: 181 LSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES 240
LSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES
Sbjct: 181 LSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES 240
Query: 241 KGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV 300
KGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV
Sbjct: 241 KGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV 300
Query: 301 EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADIL 360
EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADIL
Sbjct: 301 EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADIL 360
Query: 361 SPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE 420
SPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE
Sbjct: 361 SPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE 420
Query: 421 PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA 480
PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA
Sbjct: 421 PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA 480
Query: 481 APPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM 540
APPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM
Sbjct: 481 APPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM 540
Query: 541 QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS 600
QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS
Sbjct: 541 QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS 600
Query: 601 KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRI 660
KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRI
Sbjct: 601 KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRI 660
Query: 661 PRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEA 720
PRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEA
Sbjct: 661 PRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEA 720
Query: 721 HIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMS 780
HIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMS
Sbjct: 721 HIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMS 780
Query: 781 LYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKL 840
LYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKL
Sbjct: 781 LYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKL 840
Query: 841 SESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEF 900
SESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEF
Sbjct: 841 SESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEF 900
Query: 901 PHPDARLGFEQAFDEAKRKLASSKSCLDPEFLK 933
PHPDARLGFEQAFDEAKRKLASSKSCLDPEFLK
Sbjct: 901 PHPDARLGFEQAFDEAKRKLASSKSCLDPEFLK 933
>ref|XP_012074.1| KIAA0337 gene product [Homo sapiens]
Length = 846
Score = 1403 bits (3593), Expect = 0.0
Identities = 689/690 (99%), Positives = 689/690 (99%)
Query: 1 MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGS 60
MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGS
Sbjct: 152 MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGS 211
Query: 61 DAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS 120
DAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS
Sbjct: 212 DAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS 271
Query: 121 SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSEFSNGEAGEAYRS 180
SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSE SNGEAGEAYRS
Sbjct: 272 SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSELSNGEAGEAYRS 331
Query: 181 LSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES 240
LSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES
Sbjct: 332 LSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES 391
Query: 241 KGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV 300
KGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV
Sbjct: 392 KGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV 451
Query: 301 EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADIL 360
EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADIL
Sbjct: 452 EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADIL 511
Query: 361 SPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE 420
SPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE
Sbjct: 512 SPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE 571
Query: 421 PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA 480
PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA
Sbjct: 572 PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA 631
Query: 481 APPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM 540
APPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM
Sbjct: 632 APPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM 691
Query: 541 QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS 600
QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS
Sbjct: 692 QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS 751
Query: 601 KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRI 660
KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRI
Sbjct: 752 KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRI 811
Query: 661 PRYELLVKDLLKHTPEDHPDHPLLLEAQRN 690
PRYELLVKDLLKHTPEDHPDHPLLLEAQRN
Sbjct: 812 PRYELLVKDLLKHTPEDHPDHPLLLEAQRN 841
>gb|AAF55465.1| (AE003719) CG7397 gene product [Drosophila melanogaster]
Length = 1101
Score = 291 bits (738), Expect = 2e-77
Identities = 165/424 (38%), Positives = 256/424 (59%), Gaps = 10/424 (2%)
Query: 512 DMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHH 571
D R +V + EQSYVESL+T++ Y++ LK PE++ + D VDEIF +P++LE H
Sbjct: 153 DTRTYVVQEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIH 212
Query: 572 EQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPA 631
E+FL ++ + W QQKVG + +FSK ++ +Y+++++N AK+A+R K RP+
Sbjct: 213 EKFLSDLKSRLDDWDVQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPS 272
Query: 632 FLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNI 691
F KFLE + RE+K K L +L+IKPVQ+ P YELL + L+KHT DHPD L + + +
Sbjct: 273 FSKFLETTAREHKGKLTLDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVLKLV 332
Query: 692 KQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKK 751
+ IN R E + L+E+E IEG+ DL AP R+FL ++V G +K
Sbjct: 333 HDILVHINCKEREIMENGQREATLRELEGVIEGITDLIAPERQFLLFDLVSMPSGQGARK 392
Query: 752 DRSLFLFTDLIVCTTLKRKSGSLRRSSMSLY--TAASVIDTASKYKMLWKLPLEDADIIK 809
DR FLF DL+V T++K++SG++R+ + S+ T A+ +DT +KYK L K+ L+ +I+K
Sbjct: 393 DRGFFLFNDLLVLTSIKKRSGTIRKPNSSICPGTVATTLDT-NKYKFLTKISLDCLEIVK 451
Query: 810 GASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEK 869
S+ N + I I L ED L Q++ ++ ++ +PHQ L+D +R+L + R LSE+
Sbjct: 452 --SKDENIKRIVSEIETLAEDCNKLQQITDITVTIKYPHQYLEDVIRELHREVQRQLSER 509
Query: 870 QALCYALSFPPTKLELCATRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASS-KSCLD 928
Q L+ LEL + P G F + R +E++F+EAK+KLA++ +
Sbjct: 510 QTNDTQLNM----LELTVSSPNGNQKLAVVFSKTEKRTQWEESFNEAKQKLAATLERHPI 565
Query: 929 PEFL 932
PEFL
Sbjct: 566 PEFL 569
>pir||T16657 hypothetical protein R02F2.3 - Caenorhabditis elegans
gb|AAA50717.1| (U00055) similar to guanine-nucleotide releasing factors including
BCR [Caenorhabditis elegans]
Length = 620
Score = 171 bits (428), Expect = 4e-41
Identities = 90/226 (39%), Positives = 140/226 (61%), Gaps = 4/226 (1%)
Query: 503 SKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFD 562
S+ + +R A LLDTE+S+VE L L+ YM+PL+QP L + SLVD+IF
Sbjct: 341 SRASLRRHYSVRHLAARELLDTEKSFVEGLEFLVTKYMRPLRQPLECTLIEASLVDKIFY 400
Query: 563 QIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAV 622
+IPE+L HH+ L + + WH +G +L+ FSK ++ Y +++DNF AK ++
Sbjct: 401 RIPEILAHHQVLLTTLSQRIDQWHKDAILGDVLLAHFSKQSMIETYISFVDNFKFAKASI 460
Query: 623 RVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHP 682
A++ + AF K+ + R++ K L L+I P+QR+PRYEL+VK +LKHTP +H D
Sbjct: 461 IQARQ-KHAFEKYYNRCCRDHPNKLDLDSLLISPIQRVPRYELIVKQMLKHTPVEHEDRE 519
Query: 683 LLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDL 728
LL AQR+I +A IN+ +E+ E+ L+EIEA ++G++D+
Sbjct: 520 RLLRAQRHIHCLAVAINQHKDGSEQMEQR---LREIEAIVDGLDDV 562
>dbj|BAB12119.1| (AB047595) hypothetical protein [Macaca fascicularis]
Length = 567
Score = 160 bits (400), Expect = 8e-38
Identities = 104/376 (27%), Positives = 187/376 (49%), Gaps = 21/376 (5%)
Query: 495 PADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDP 554
PA E P + S QV +R+H+ +++ +E SYVESL+ ++Q Y PL + E L
Sbjct: 53 PAPELGPMPEGLSPQQV-VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKAL-SA 110
Query: 555 SLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDN 614
+F ++ E+L H F + + W + +K+G L V SFSK +++++YS Y++N
Sbjct: 111 RKCQAVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNN 170
Query: 615 FLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT 674
F +A ++ A +PAFL+FL++ + ++ L LM+KP+QR P++ LL++D+LK+T
Sbjct: 171 FTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNT 230
Query: 675 PEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRR 734
P HPD L A ++ +AE++N+ R A++ +Q++ + L L
Sbjct: 231 PRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAE----IQQLTKSVSDRSSLNKLLTS 286
Query: 735 FLRQEMVIE--VKAIGG-------KKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAA 785
RQ ++ E + + G K+R +FL D++VC + K + R + + +
Sbjct: 287 GQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPAN-HRGQLEI---S 342
Query: 786 SVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLG 845
S++ KY + W L +++ + I + ++ LG
Sbjct: 343 SLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHAGAKKASTSGQAQNKVYLG 402
Query: 846 FPH--QSLDDALRDLS 859
P Q L D +DL+
Sbjct: 403 PPRLFQELQDLQKDLA 418
>dbj|BAB13452.1| (AB046846) KIAA1626 protein [Homo sapiens]
Length = 1284
Score = 159 bits (398), Expect = 1e-37
Identities = 104/376 (27%), Positives = 187/376 (49%), Gaps = 21/376 (5%)
Query: 495 PADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDP 554
PA E P + S QV +R+H+ +++ +E SYVESL+ ++Q Y PL + E L
Sbjct: 304 PAPELGPMPEGLSPQQV-VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKAL-SA 361
Query: 555 SLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDN 614
+F ++ E+L H F + + W + +K+G L V SFSK +++++YS Y++N
Sbjct: 362 RKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNN 421
Query: 615 FLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT 674
F +A ++ A +PAFL+FL++ + ++ L LM+KP+QR P++ LL++D+LK+T
Sbjct: 422 FTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNT 481
Query: 675 PEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRR 734
P HPD L A ++ +AE++N+ R A++ +Q++ + L L
Sbjct: 482 PRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAE----IQQLTKSVSDRSSLNKLLTS 537
Query: 735 FLRQEMVIE--VKAIGG-------KKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAA 785
RQ ++ E + + G K+R +FL D++VC + K + R + + +
Sbjct: 538 GQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPAN-HRGQLEI---S 593
Query: 786 SVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLG 845
S++ KY + W L +++ + I + ++ LG
Sbjct: 594 SLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLG 653
Query: 846 FPH--QSLDDALRDLS 859
P Q L D +DL+
Sbjct: 654 PPRLFQELQDLQKDLA 669
>ref|NP_055444.1| Rho guanine nucleotide exchange factor (GEF) 10 [Homo sapiens]
dbj|BAA20754.1| (AB002292) KIAA0294 [Homo sapiens]
Length = 1121
Score = 158 bits (395), Expect = 3e-37
Identities = 104/382 (27%), Positives = 202/382 (52%), Gaps = 28/382 (7%)
Query: 486 EAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQ 545
+ K PEA TP + S+ QV +R+++ +++D+E++YV++L+ +++ Y +PL +
Sbjct: 152 DCKHPEAIL-----TPMPEGLSQQQV-VRRYILGSVVDSEKNYVDALKRILEQYEKPLSE 205
Query: 546 PENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLV 605
E VL + L +F ++ E+L+ H F + + W + + +G + V SFSK +++
Sbjct: 206 MEPKVLSERKL-KTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVL 264
Query: 606 NIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYEL 665
+ YS Y++NF A ++ +PAFL+FL+Q + ++ L LM+KP+QR P++ L
Sbjct: 265 DAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFIL 324
Query: 666 LVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEI-EAHIEG 724
L++D+LK+T + HPD L A ++ +AE++N+ R A++ ++ + I E ++
Sbjct: 325 LLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNK 384
Query: 725 MEDLQAPLRRFLRQEMVIEV-----KAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSM 779
+ L + R +R + +IE I K+R +F+ D+++C T+ + R
Sbjct: 385 L--LSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSR--- 439
Query: 780 SLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTL--GQM 837
+ ++ +Y + W +PL D I+ S A E+ + E L + +
Sbjct: 440 --------VMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKP 491
Query: 838 SKLSESLGFPHQSLDDALRDLS 859
+K+ G +Q L + L DL+
Sbjct: 492 NKVYMGPGQLYQDLQNLLHDLN 513
>pir||T03307 hypothetical protein AAB71662.1 - human (fragment)
gb|AAB71662.1| (AF009205) unknown [Homo sapiens]
Length = 988
Score = 156 bits (391), Expect = 9e-37
Identities = 104/382 (27%), Positives = 201/382 (52%), Gaps = 28/382 (7%)
Query: 486 EAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQ 545
+ K PEA TP + S+ QV +R+++ +++D+E++YV++L+ +++ Y +PL +
Sbjct: 48 DCKHPEAIL-----TPMPEGLSQQQV-VRRYILGSVVDSEKNYVDALKRILEQYEKPLSE 101
Query: 546 PENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLV 605
E VL + L +F ++ E+L+ H F + + W + + +G + V SFSK +++
Sbjct: 102 MEPKVLSERKL-KTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVL 160
Query: 606 NIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYEL 665
+ YS Y++NF A ++ +PAFL+FL+Q + ++ L LM+KP QR P++ L
Sbjct: 161 DAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPXQRFPQFIL 220
Query: 666 LVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEI-EAHIEG 724
L++D+LK+T + HPD L A ++ +AE++N+ R A++ ++ + I E ++
Sbjct: 221 LLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNK 280
Query: 725 MEDLQAPLRRFLRQEMVIEV-----KAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSM 779
+ L + R +R + +IE I K+R +F+ D+++C T+ + R
Sbjct: 281 L--LSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSR--- 335
Query: 780 SLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTL--GQM 837
+ ++ +Y + W +PL D I+ S A E+ + E L + +
Sbjct: 336 --------VMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKP 387
Query: 838 SKLSESLGFPHQSLDDALRDLS 859
+K+ G +Q L + L DL+
Sbjct: 388 NKVYMGPGQLYQDLQNLLHDLN 409
>gb|AAB60388.1| (U07000) breakpoint cluster region protein [Homo sapiens]
Length = 1271
Score = 135 bits (337), Expect = 2e-30
Identities = 97/316 (30%), Positives = 154/316 (48%), Gaps = 46/316 (14%)
Query: 498 EPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPS 555
E T AS+ + ++MRK V +L +E++Y+ L L+ M+PLK + +
Sbjct: 483 ESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQ 541
Query: 556 LVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNF 615
++ IF ++PEL E H++F + + +Q W QQ+VG L + S+ + +Y A++DN+
Sbjct: 542 QIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNY 598
Query: 616 LNAKDAVRVAKEARPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVK 668
A + +A F + E R NK+ K +L L+ KPV R+ R L++
Sbjct: 599 GVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLH 658
Query: 669 DLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDL 728
DLLKHTP HPDHPLL +A R + IN +EI + M
Sbjct: 659 DLLKHTPASHPDHPLLQDALRISQNFLSSIN----------------EEITPRRQSMTVK 702
Query: 729 QAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVI 788
+ R+ L+ ++E+ G +K R +FLFTDL++CT LK++SG
Sbjct: 703 KGEHRQLLKDSFMVEL-VEGARKLRHVFLFTDLLLCTKLKKQSGG--------------- 746
Query: 789 DTASKYKMLWKLPLED 804
+Y W +PL D
Sbjct: 747 -KTQQYDCKWYIPLTD 761
>gb|AAA65939.1| (M24603) bcr [Homo sapiens]
Length = 872
Score = 134 bits (333), Expect = 6e-30
Identities = 96/316 (30%), Positives = 154/316 (48%), Gaps = 46/316 (14%)
Query: 498 EPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPS 555
E T AS+ + ++MRK V +L +E++Y+ L L+ M+PLK + +
Sbjct: 483 ESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQ 541
Query: 556 LVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNF 615
++ IF ++PEL E H++F + + +Q W QQ+VG L + S+ + +Y A++DN+
Sbjct: 542 QIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNY 598
Query: 616 LNAKDAVRVAKEARPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVK 668
A + +A F + E R NK+ K +L L+ KPV R+ R L++
Sbjct: 599 GVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLH 658
Query: 669 DLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDL 728
DLLKHTP HPDHPLL +A R + IN +EI + M
Sbjct: 659 DLLKHTPASHPDHPLLQDALRISQNFLSSIN----------------EEITPRRQSMTVK 702
Query: 729 QAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVI 788
+ R+ L+ ++E+ G +K R +FLFT+L++CT LK++SG
Sbjct: 703 KGEHRQLLKDSFMVEL-VEGARKLRHVFLFTELLLCTKLKKQSGG--------------- 746
Query: 789 DTASKYKMLWKLPLED 804
+Y W +PL D
Sbjct: 747 -KTQQYDCKWYIPLTD 761
>ref|NP_004318.2| breakpoint cluster region, isoform 1 [Homo sapiens]
sp|P11274|BCR_HUMAN BREAKPOINT CLUSTER REGION PROTEIN
pir||TVHUBR bcr (breakpoint cluster region) protein, splice form 1 - human
emb|CAA26441.1| (X02596) bcr [Homo sapiens]
Length = 1271
Score = 134 bits (333), Expect = 6e-30
Identities = 96/316 (30%), Positives = 154/316 (48%), Gaps = 46/316 (14%)
Query: 498 EPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPS 555
E T AS+ + ++MRK V +L +E++Y+ L L+ M+PLK + +
Sbjct: 483 ESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQ 541
Query: 556 LVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNF 615
++ IF ++PEL E H++F + + +Q W QQ+VG L + S+ + +Y A++DN+
Sbjct: 542 QIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNY 598
Query: 616 LNAKDAVRVAKEARPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVK 668
A + +A F + E R NK+ K +L L+ KPV R+ R L++
Sbjct: 599 GVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLH 658
Query: 669 DLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDL 728
DLLKHTP HPDHPLL +A R + IN +EI + M
Sbjct: 659 DLLKHTPASHPDHPLLQDALRISQNFLSSIN----------------EEITPRRQSMTVK 702
Query: 729 QAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVI 788
+ R+ L+ ++E+ G +K R +FLFT+L++CT LK++SG
Sbjct: 703 KGEHRQLLKDSFMVEL-VEGARKLRHVFLFTELLLCTKLKKQSGG--------------- 746
Query: 789 DTASKYKMLWKLPLED 804
+Y W +PL D
Sbjct: 747 -KTQQYDCKWYIPLTD 761
>gb|AAB60390.1| (U07000) breakpoint cluster region protein [Homo sapiens]
Length = 936
Score = 132 bits (330), Expect = 1e-29
Identities = 113/398 (28%), Positives = 181/398 (45%), Gaps = 66/398 (16%)
Query: 425 VGPPVAVPEPIGFP---TRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLAA 481
+GP + V P GFP R+ L +L+ + A + P L
Sbjct: 77 LGPAMPVSSP-GFPGPCARSEHHLDTAALQTGQRS----------SAGTKMGCPTLMTRP 125
Query: 482 P--PSAEAKPPEA----ARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTL 535
P P++ A+ A +R P S+ + ++MRK V +L +E++Y+ L L
Sbjct: 126 PHRPTSAARAGAAGMRWSREPWSPLKRSELDLEKGLEMRKWVLSGILASEETYLSHLEAL 185
Query: 536 MQGYMQPLKQPENSV--LCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGA 593
+ M+PLK + + ++ IF ++PEL E H++F + + +Q W QQ+VG
Sbjct: 186 LLP-MKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGD 244
Query: 594 LLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQ-SMRENKE------K 646
L + S+ + +Y A++DN+ A + +A F + E R NK+ K
Sbjct: 245 LFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTK 301
Query: 647 QALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAE 706
+L L+ KPV R+ R L++ DLLKHTP HPDHPLL +A R + IN
Sbjct: 302 NSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSIN------- 354
Query: 707 EAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTT 766
+EI + M + R+ L+ ++E+ G +K R +FLFTDL++CT
Sbjct: 355 ---------EEITPRRQSMTVKKGEHRQLLKDSFMVEL-VEGARKLRHVFLFTDLLLCTK 404
Query: 767 LKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLED 804
LK++SG +Y W +PL D
Sbjct: 405 LKKQSGG----------------KTQQYDCKWYIPLTD 426
>gb|AAB60389.1| (U07000) breakpoint cluster region protein [Homo sapiens]
Length = 889
Score = 132 bits (329), Expect = 2e-29
Identities = 95/315 (30%), Positives = 152/315 (48%), Gaps = 46/315 (14%)
Query: 499 PTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSL 556
P S+ + ++MRK V +L +E++Y+ L L+ M+PLK + +
Sbjct: 102 PLKRSELDLEKGLEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQQ 160
Query: 557 VDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFL 616
++ IF ++PEL E H++F + + +Q W QQ+VG L + S+ + +Y A++DN+
Sbjct: 161 IETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYG 217
Query: 617 NAKDAVRVAKEARPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVKD 669
A + +A F + E R NK+ K +L L+ KPV R+ R L++ D
Sbjct: 218 VAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHD 277
Query: 670 LLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQ 729
LLKHTP HPDHPLL +A R + IN +EI + M +
Sbjct: 278 LLKHTPASHPDHPLLQDALRISQNFLSSIN----------------EEITPRRQSMTVKK 321
Query: 730 APLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVID 789
R+ L+ ++E+ G +K R +FLFTDL++CT LK++SG
Sbjct: 322 GEHRQLLKDSFMVEL-VEGARKLRHVFLFTDLLLCTKLKKQSGG---------------- 364
Query: 790 TASKYKMLWKLPLED 804
+Y W +PL D
Sbjct: 365 KTQQYDCKWYIPLTD 379
>ref|NP_067585.1| breakpoint cluster region, isoform 2 [Homo sapiens]
emb|CAA68676.1| (Y00661) bcr polypeptide [Homo sapiens]
Length = 1227
Score = 131 bits (325), Expect = 5e-29
Identities = 95/314 (30%), Positives = 152/314 (48%), Gaps = 46/314 (14%)
Query: 500 TPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLV 557
T AS+ + ++MRK V +L +E++Y+ L L+ M+PLK + + +
Sbjct: 485 TKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQQI 543
Query: 558 DEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLN 617
+ IF ++PEL E H++ + + +Q W QQ+VG L + S+ + +Y A++DN+
Sbjct: 544 ETIFFKVPELYEIHKESYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGV 600
Query: 618 AKDAVRVAKEARPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVKDL 670
A + +A F + E R NK+ K +L L+ KPV R+ R L++ DL
Sbjct: 601 AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL 660
Query: 671 LKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQA 730
LKHTP HPDHPLL +A R + IN +EI + M +
Sbjct: 661 LKHTPASHPDHPLLQDALRISQNFLSSIN----------------EEITPRRQSMTVKKG 704
Query: 731 PLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDT 790
R+ L+ ++E+ G +K R +FLFTDL++CT LK++SG
Sbjct: 705 EHRQLLKDSFMVEL-VEGARKLRHVFLFTDLLLCTKLKKQSGG----------------K 747
Query: 791 ASKYKMLWKLPLED 804
+Y W +PL D
Sbjct: 748 TQQYDCKWYIPLTD 761
>gb|AAB69637.1| (U82517) GrfA [Dictyostelium discoideum]
Length = 479
Score = 121 bits (301), Expect = 3e-26
Identities = 78/282 (27%), Positives = 144/282 (50%), Gaps = 18/282 (6%)
Query: 491 EAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV 550
E+AR A E A K R H+ ++ E +YV++L +++ ++ PL Q S
Sbjct: 132 ESARLAQEAARAQK---------RTHIVQEIMQVEVNYVKNLTLMVRKFLHPLAQLSTSK 182
Query: 551 --LCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDV--LVN 606
L P + +IF I + H+ F + + ++ W A K L++ + + +
Sbjct: 183 RPLLTPDRITQIFSTIENIQNHNSIFSDGLTSRIKRWLADNKKDHLIIGDIFQKIGGFMQ 242
Query: 607 IYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYEL 665
YS YI+N+ + K+ F +F+++ + + + L +L+I PVQ++PRY +
Sbjct: 243 DYSKYINNYNQSIKTYNETKKTNLPFAQFIKKVESDPELNDRELENLLITPVQQLPRYIM 302
Query: 666 LVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGM 725
L++DL+++T +DHPD+ L EA IK + IN+ R AE+A ++ Q++ +
Sbjct: 303 LIQDLIRNTHDDHPDYKPLTEALDKIKHITTIINEKKRDAEDAFAMLQIHQQVHGKVP-- 360
Query: 726 EDLQAPLRRFLRQEMVIEVKAIGGKKDRS--LFLFTDLIVCT 765
+ P R+F+R+ V + G KD+ +FLF D+++ T
Sbjct: 361 NNFVTPHRKFIREGAVHFGSSSGSFKDKDPIVFLFNDMVMMT 402
>gb|AAF48732.1| (AE003505) CG8557 gene product [Drosophila melanogaster]
Length = 1783
Score = 118 bits (294), Expect = 2e-25
Identities = 83/326 (25%), Positives = 150/326 (45%), Gaps = 42/326 (12%)
Query: 501 PASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEI 560
PA S+ Q+ R+H+ ++ +E SYV +L+ L+ Y +PL++ VL +P + +
Sbjct: 446 PAPAGLSQQQLK-RRHIVAAIVHSENSYVATLQRLVNDYKKPLEECSPPVL-NPVKIATL 503
Query: 561 FDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKD 620
F +P++L H+ F + C++ W +K+G V +F K L+ IYS +I+NF A +
Sbjct: 504 FHCLPDILHSHKLFRISLAECVRNWDRDEKIGDCFVSAFGKPQLLEIYSGFINNFSAAME 563
Query: 621 AVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPD 680
++ ++ + A F + ++ + LM+KPVQR P++ L ++DLLK+TP+ H D
Sbjct: 564 LAKMEEKRKSALADFFKVKQISAHDRLSFFGLMVKPVQRFPQFILFLQDLLKYTPQGHHD 623
Query: 681 HPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEM 740
L ++ V+ V + R +L+ E ++ ME QA
Sbjct: 624 RMSL-----HLSSVS------VSDSAGGHRPRYLLR--EDNVTHMEFNQAGF-------- 662
Query: 741 VIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKL 800
I K R L L D ++C ++ K + K W
Sbjct: 663 ------IVKCKQRRLLLLNDKVICVSVAPKQ-------------SHDFGATEKLTFKWMF 703
Query: 801 PLEDADIIKGASQATNRENIQKAISR 826
P+ D +I+ ++ AT + ++R
Sbjct: 704 PVNDVEIVDNSTSATLSRILTAGLNR 729
>pir||T18289 racGAP protein - slime mold (Dictyostelium discoideum)
emb|CAA71241.1| (Y10159) racGAP [Dictyostelium discoideum]
Length = 1335
Score = 113 bits (280), Expect = 1e-23
Identities = 129/519 (24%), Positives = 216/519 (40%), Gaps = 71/519 (13%)
Query: 399 PSSRHVRHASVPATFMPIVVPEPP--------TSVGPPVAVPEPIGFPTRAHPTLQAPSL 450
PS + A++P PEPP T + PP P P F A T
Sbjct: 648 PSLLPIDLANLPPPPFSPCSPEPPQIQNLNINTDLPPP---PPPPNFIDNATTTTTTTDD 704
Query: 451 EDVTKQYM--------------LNLHSGEVPA------PVPVDMPCLPLAAPPSAEAKPP 490
ED + ++ +GE+ P+P +P + A P PP
Sbjct: 705 EDSNNSNLNIYNLPPPIFNIGDIDFENGELAKMDISFIPLPPPLPAVVPANIPPPPPPPP 764
Query: 491 EAARPADEPTPASKCCSKPQVDMRK---HVAMTLLDTEQSYVESLRTLMQGYMQPLKQPE 547
+ D K + + +++K A L TEQ+YV+ L + +++P K+ +
Sbjct: 765 KKLDRKDSYIHKKKMSQEKENEIKKKRRERAEETLTTEQTYVKQLTVVYDNFIEPYKKTQ 824
Query: 548 NSVLCDPSLVDEIFDQIPELLEHHE-QFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVN 606
+IF+ + +L H+ L+ + M W ++ ++G + + + S +
Sbjct: 825 KCHGLTGEEFMDIFNCLEVILSSHKTNLLKPIEDRMLVWDSKPQMGDIFLNNTS---FIK 881
Query: 607 IYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYEL 665
+Y Y++N+ + + KE F ++ EN +L ++ P+Q +PRY +
Sbjct: 882 LYKHYVNNYDKSIRTLNQCKEKYDGFKTYMASLDYSENLSNLSLESFLVLPIQPLPRYVM 941
Query: 666 LVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGM 725
L++DLLK+T DH D L EA IK + E IN E + + ++LQ ++ I+ M
Sbjct: 942 LLQDLLKYTANDHEDFNQLCEALSTIKDLTESIN---TKKSEEDNNTKILQ-VQEQIKDM 997
Query: 726 EDLQAPLRRFLRQEMVIEVKAIGGKKDR-SLFLFTDLIVCT----TLKRKSGSLRRSSMS 780
P LR+ V E A+ KKD+ +FLFTD ++ T K+ + S+ S
Sbjct: 998 ----PPNTMTLRKRFVTE-GALTLKKDKYYVFLFTDRMILTKPGKEKKKFKNIINLSTAS 1052
Query: 781 LYT-----AASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDL--TT 833
L T VI +K P E +K +I+ AI +DL T
Sbjct: 1053 LNTTDEQNVLKVISQEGTFKFSTDNPAEREHWVK---------DIKDAIDTARQDLIQTA 1103
Query: 834 LGQMSKLSE-SLGFPH-QSLDDALRDLSAAMHRDLSEKQ 870
G+ + L+E S GF Q + L+ A LSE++
Sbjct: 1104 FGESTTLNEGSKGFNKIQDEKNMLKKQKLAQELALSEEE 1142
Score = 66.0 bits (158), Expect = 2e-09
Identities = 46/206 (22%), Positives = 97/206 (46%), Gaps = 11/206 (5%)
Query: 514 RKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQ----PENSVLCDPSLVDEIFDQIPELLE 569
++ +A L +E+ YV+SL + ++QP+K+ P V +L EI L
Sbjct: 1129 KQKLAQELALSEEEYVDSLTYIYNVFLQPIKKSIDTPNQLVSYQENL--EISSNFETLFS 1186
Query: 570 HHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEAR 629
H+ FL ++ + W ++ + + ++ K + +Y+ Y+ N + + E
Sbjct: 1187 CHKTFLIALKERIAEWDSKPLMSDIFME---KAGFLKLYNYYVQNHTRSLQVLEHCIEKY 1243
Query: 630 PAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQR 689
F L++ E+ + L L+ +P++R+ +Y L+++++L++T H D+ L
Sbjct: 1244 SLFAIHLKRI--ESDQNTELKVLLAQPLRRVSKYYLVLREILQYTRPKHDDYDALNRVVA 1301
Query: 690 NIKQVAERINKGVRSAEEAERHARVL 715
N+K ++ N S AE ++ L
Sbjct: 1302 NLKDQTDKFNANSTSQMSAEAGSKYL 1327
>pir||B47485 ABR protein 2 - human
Length = 813
Score = 110 bits (273), Expect = 6e-23
Identities = 84/327 (25%), Positives = 146/327 (43%), Gaps = 58/327 (17%)
Query: 489 PPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPEN 548
PPE P E ++MRK V L +E+ Y+ L L+ M+PLK
Sbjct: 29 PPEGLAPGVEAGKG--------LEMRKLVLSGFLASEEIYINQLEALLLP-MKPLKA--T 77
Query: 549 SVLCDPSL----VDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVL 604
+ P L ++ IF +I ++ E H++F + + +Q W +Q +G L + S+
Sbjct: 78 ATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ--- 134
Query: 605 VNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQ-------SMRENKEKQALSDLMIKPV 657
+ +Y A++DN+ A + ++ F K E+ +++ + L+ KP+
Sbjct: 135 LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPI 194
Query: 658 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 717
R+ R L++ DLLKHTP DHPD+PLL +A R + IN ++
Sbjct: 195 DRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSIN----------------ED 238
Query: 718 IEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRS 777
I+ + + R+ ++ ++EV +K R +FLFTD+++C LK+ S +
Sbjct: 239 IDPRRTAVTTPKGETRQLVKDGFLVEVSE-SSRKLRHVFLFTDVLLCAKLKKTSAGKHQ- 296
Query: 778 SMSLYTAASVIDTASKYKMLWKLPLED 804
+Y W +PL D
Sbjct: 297 ---------------QYDCKWYIPLAD 308
>ref|NP_068781.1| active breakpoint cluster region-related protein, isoform a [Homo
sapiens]
sp|Q12979|ABR_HUMAN ACTIVE BREAKPOINT CLUSTER REGION-RELATED PROTEIN
pir||A49307 98K GTPase-activating protein ABR, brain - human
gb|AAC50063.1| (U01147) guanine nucleotide regulatory protein [Homo sapiens]
Length = 859
Score = 110 bits (273), Expect = 6e-23
Identities = 84/327 (25%), Positives = 146/327 (43%), Gaps = 58/327 (17%)
Query: 489 PPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPEN 548
PPE P E ++MRK V L +E+ Y+ L L+ M+PLK
Sbjct: 75 PPEGLAPGVEAGKG--------LEMRKLVLSGFLASEEIYINQLEALLLP-MKPLKA--T 123
Query: 549 SVLCDPSL----VDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVL 604
+ P L ++ IF +I ++ E H++F + + +Q W +Q +G L + S+
Sbjct: 124 ATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ--- 180
Query: 605 VNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQ-------SMRENKEKQALSDLMIKPV 657
+ +Y A++DN+ A + ++ F K E+ +++ + L+ KP+
Sbjct: 181 LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPI 240
Query: 658 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 717
R+ R L++ DLLKHTP DHPD+PLL +A R + IN ++
Sbjct: 241 DRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSIN----------------ED 284
Query: 718 IEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRS 777
I+ + + R+ ++ ++EV +K R +FLFTD+++C LK+ S +
Sbjct: 285 IDPRRTAVTTPKGETRQLVKDGFLVEVSE-SSRKLRHVFLFTDVLLCAKLKKTSAGKHQ- 342
Query: 778 SMSLYTAASVIDTASKYKMLWKLPLED 804
+Y W +PL D
Sbjct: 343 ---------------QYDCKWYIPLAD 354
>ref|NP_001083.1| active breakpoint cluster region-related protein, isoform b [Homo
sapiens]
pir||A47485 ABR protein 1 - human
gb|AAC37519.1| (L19704) alternative first exon [Homo sapiens]
Length = 822
Score = 109 bits (270), Expect = 1e-22
Identities = 79/305 (25%), Positives = 141/305 (45%), Gaps = 50/305 (16%)
Query: 511 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSL----VDEIFDQIPE 566
++MRK V L +E+ Y+ L L+ M+PLK + P L ++ IF +I +
Sbjct: 52 LEMRKLVLSGFLASEEIYINQLEALLLP-MKPLKA--TATTSQPVLTIQQIETIFYKIQD 108
Query: 567 LLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAK 626
+ E H++F + + +Q W +Q +G L + S+ + +Y A++DN+ A +
Sbjct: 109 IYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNYKVALETAEKCS 165
Query: 627 EARPAFLKFLEQ-------SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHP 679
++ F K E+ +++ + L+ KP+ R+ R L++ DLLKHTP DHP
Sbjct: 166 QSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHP 225
Query: 680 DHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQE 739
D+PLL +A R + IN ++I+ + + R+ ++
Sbjct: 226 DYPLLQDALRISQNFLSSIN----------------EDIDPRRTAVTTPKGETRQLVKDG 269
Query: 740 MVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWK 799
++EV +K R +FLFTD+++C LK+ S + +Y W
Sbjct: 270 FLVEVSE-SSRKLRHVFLFTDVLLCAKLKKTSAGKHQ----------------QYDCKWY 312
Query: 800 LPLED 804
+PL D
Sbjct: 313 IPLAD 317
>gb|AAA35594.1| (M15025) BCR-ABL protein [Homo sapiens]
Length = 693
Score = 109 bits (269), Expect = 2e-22
Identities = 71/214 (33%), Positives = 114/214 (53%), Gaps = 13/214 (6%)
Query: 498 EPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPS 555
E T AS+ + ++MRK V +L +E++Y+ L L+ M+PLK + +
Sbjct: 483 ESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQ 541
Query: 556 LVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNF 615
++ IF ++PEL E H++F + + +Q W QQ+VG L + S+ + +Y A++DN+
Sbjct: 542 QIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNY 598
Query: 616 LNAKDAVRVAKEARPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVK 668
A + +A F + E R NK+ K +L L+ KPV R+ R L++
Sbjct: 599 GVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLH 658
Query: 669 DLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGV 702
DLLKHTP HPDHPLL +A R + IN+ +
Sbjct: 659 DLLKHTPASHPDHPLLQDALRISQNFLSSINEEI 692
>gb|AAF50508.1| (AE003557) pbl gene product [Drosophila melanogaster]
Length = 851
Score = 108 bits (267), Expect = 3e-22
Identities = 92/312 (29%), Positives = 145/312 (45%), Gaps = 24/312 (7%)
Query: 481 APPSAEAKPPEAARP-ADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGY 539
+P E+ A P A + TPA K MR + M TE +YV L T++ +
Sbjct: 358 SPDKLESDKLLHAEPEASDATPAKK-------SMRFNHFMDFYTTESNYVGILDTILNLF 410
Query: 540 MQPLKQ--PENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQ 597
L++ N L + S + IF + E H+ LE +R W +G +++Q
Sbjct: 411 KNKLEELAETNDPLLNKSEIKTIFGNFLPIHEVHQSMLEHLRKLHANWREDCLIGDIIIQ 470
Query: 598 SFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENK-EKQALSDLMIKP 656
+D L+ Y Y++ F K+ ++ P F FL+ + + + +Q L DLMI+P
Sbjct: 471 H--RDELIKAYPPYVNFFEQMKEQLQYCDREYPRFHAFLKINQTKPECGRQGLQDLMIRP 528
Query: 657 VQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQ 716
VQR+P LL+ D+LKHT + DH L EA + IKQV IN+ R E +
Sbjct: 529 VQRLPSISLLLNDILKHTTSGNADHGRLEEALKAIKQVTLHINEDKRRTESRMAIFDIFN 588
Query: 717 EIE---AHIEGMEDLQAPLRRFLRQEMVIEVK-AIGGKKDR-SLFLFTDLIVCTTLKRKS 771
+IE AH L + R F+ + V E+ ++ G+ D L+LF+D I + K
Sbjct: 589 DIEGCPAH------LVSSNRSFILKCEVNELSDSLSGRGDSLVLYLFSDSIELCKRRSKG 642
Query: 772 GSLRRSSMSLYT 783
+ +S + T
Sbjct: 643 FNTAKSPSTAKT 654
>gb|AAD52845.1|AF136492_1 (AF136492) Pebble [Drosophila melanogaster]
Length = 853
Score = 108 bits (267), Expect = 3e-22
Identities = 92/312 (29%), Positives = 145/312 (45%), Gaps = 24/312 (7%)
Query: 481 APPSAEAKPPEAARP-ADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGY 539
+P E+ A P A + TPA K MR + M TE +YV L T++ +
Sbjct: 360 SPDKLESDKLLHAEPEASDATPAKK-------SMRFNHFMDFYTTESNYVGILDTILNLF 412
Query: 540 MQPLKQ--PENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQ 597
L++ N L + S + IF + E H+ LE +R W +G +++Q
Sbjct: 413 KNKLEELAETNDPLLNKSEIKTIFGNFLPIHEVHQSMLEHLRKLHANWREDCLIGDIIIQ 472
Query: 598 SFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENK-EKQALSDLMIKP 656
+D L+ Y Y++ F K+ ++ P F FL+ + + + +Q L DLMI+P
Sbjct: 473 H--RDELIKAYPPYVNFFEQMKEQLQYCDREYPRFHAFLKINQTKPECGRQGLQDLMIRP 530
Query: 657 VQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQ 716
VQR+P LL+ D+LKHT + DH L EA + IKQV IN+ R E +
Sbjct: 531 VQRLPSISLLLNDILKHTTSGNADHGRLEEALKAIKQVTLHINEDKRRTESRMAIFDIFN 590
Query: 717 EIE---AHIEGMEDLQAPLRRFLRQEMVIEVK-AIGGKKDR-SLFLFTDLIVCTTLKRKS 771
+IE AH L + R F+ + V E+ ++ G+ D L+LF+D I + K
Sbjct: 591 DIEGCPAH------LVSSNRSFILKCEVNELSDSLSGRGDSLVLYLFSDSIELCKRRSKG 644
Query: 772 GSLRRSSMSLYT 783
+ +S + T
Sbjct: 645 FNTAKSPSTAKT 656
>ref|NP_031926.1| ect2 oncogene [Mus musculus]
sp|Q07139|ECT2_MOUSE ECT2 PROTEIN (ECT2 ONCOGENE)
pir||S32372 transforming protein (ect2) - mouse
gb|AAA37536.1| (L11316) ect2 [Mus musculus]
prf||1911407A oncogene ect2 [Mus musculus]
Length = 738
Score = 108 bits (266), Expect = 4e-22
Identities = 87/341 (25%), Positives = 158/341 (45%), Gaps = 40/341 (11%)
Query: 437 FPTRAHPT----LQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAPPSAEAKPPEA 492
FP R P+ L SL D++ ++H GE P
Sbjct: 224 FPPRKRPSAEHSLSIGSLLDISNTPESSIHYGETPK----------------------SC 261
Query: 493 ARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQP--ENSV 550
A+ + TP P+ R VA L TE +YV L T++Q + PL++
Sbjct: 262 AKSSRSSTPVP-----PKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGP 316
Query: 551 LCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSA 610
+ P + IF IP++ + H + + + + W + +G + ++ ++KD LV Y
Sbjct: 317 ILAPEEIKTIFGSIPDIFDVHMKIKDDLEDLIANWDESRSIGDIFLK-YAKD-LVKTYPP 374
Query: 611 YIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKD 669
+++ F +K+ + ++ +P F FL+ + + + +Q+L +L+I+PVQR+P LL+ D
Sbjct: 375 FVNFFEMSKEMIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLND 434
Query: 670 LLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQ 729
L KHT +++PD L +A ++K+V IN+ R E ++ V+ E++ +
Sbjct: 435 LKKHTADENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSH 494
Query: 730 APLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRK 770
L + + + E G++ +LFLF D C + RK
Sbjct: 495 RSLVQRVETVSLGEHPCDRGEQ-VTLFLFND---CLEIARK 531
>ref|NP_032027.1| faciogenital dysplasia homolog [Mus musculus]
sp|P52734|FGD1_MOUSE PUTATIVE RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR (RHO/RAC GEF)
(FACIOGENITAL DYSPLASIA PROTEIN HOMOLOG)
gb|AAA96001.1| (U22325) Fgd1 [Mus musculus]
Length = 960
Score = 105 bits (259), Expect = 3e-21
Identities = 132/537 (24%), Positives = 213/537 (39%), Gaps = 79/537 (14%)
Query: 278 PSRRGELAGPGFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALP 337
P R GP E PG P P+ +P + P +P S Q R LP
Sbjct: 130 PQRLRSDPGPPTEIPGPRP----SPLKRAPGPKPQV------PPKP----SYLQMPRVLP 175
Query: 338 EALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRA 397
P P R DP++A L PR + SS E + + ++
Sbjct: 176 PPEPIPPPPSRPLPADPRVAKGLVPRA-------EASTSSAAVSSLIEKFEREPVIVASD 228
Query: 398 RPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQY 457
RP+ P P ++P+PP P P G +R L AP D K
Sbjct: 229 RPAP-----GPCPVPPEPAMLPQPPPQ---PTGSQLPEGEASRCL-FLLAPGPRDGEKVP 279
Query: 458 MLNLHSGEVPAPVPVDMPCL----------------PLAAPPSAEAKP------------ 489
+ + +P + C LA+ P A A P
Sbjct: 280 NRDSGIDSISSPSNSEETCFVSDDGPPIHSLCPGPPALASMPVALADPHRPGSQEVDSDL 339
Query: 490 ------PEAARPADEPTPASKCCSKPQVDMRK---HVAMTLLDTEQSYVESLRTLMQGYM 540
E + + P P + ++ +++ H+A LL TE++YV L L Q +
Sbjct: 340 EEEEEEEEEEKEREIPVPPMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFC 399
Query: 541 -QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL-EQVRHCMQTWHAQQKVGALLVQS 598
+ L++ N +V IF I + H+QFL ++ M+ W ++G +L +
Sbjct: 400 ARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKL 459
Query: 599 FSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQ-ALSDLMIKPV 657
+ +Y Y+ NF A + V E F + + +E + L M++PV
Sbjct: 460 AP---FLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACRNLTLQHHMLEPV 516
Query: 658 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 717
QRIPRYELL+KD L P PD +AQ++++ +A + + ER ++L+
Sbjct: 517 QRIPRYELLLKDYLLKLPHGSPDSK---DAQKSLELIATAAEHSNAAIRKMERMHKLLKV 573
Query: 718 IEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KKDRSLFLFTD-LIVCTTLKRKSG 772
E + G ED+ +P + +++ ++++ A G +DR L LF D L+ C R G
Sbjct: 574 YEL-LGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLG 629
>ref|XP_010215.1| faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 104 bits (257), Expect = 5e-21
Identities = 139/560 (24%), Positives = 215/560 (37%), Gaps = 102/560 (18%)
Query: 273 KSLS-DPSRRGELAGPGFEGPGGEPIREVEPMLPPSSS-EPILVEQRAEPEEPGATRSRA 330
KSLS DP G+ P EGP P PS P+ +P+ P S
Sbjct: 113 KSLSLDP---GQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKP-SYL 168
Query: 331 QSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQ 390
Q R P P P R DP++A L+PR
Sbjct: 169 QMPRMPPPLEPIPPPPSRPLPADPRVAKGLAPR--------------------------- 201
Query: 391 TGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFP--TRAHPTLQAP 448
+ A PSS V P++V GP PEP+ P T P Q P
Sbjct: 202 ----AEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPEPVMLPQPTSQPPVPQLP 257
Query: 449 SLEDVTKQYML-----------NLHSG--EVPAPVPVDMPCL----------------PL 479
E ++L N SG + +P + C L
Sbjct: 258 EGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPAL 317
Query: 480 AAPPSAEAKP-------------------PEAARPADEPTPASKCCSKPQVDMRK---HV 517
A+ P A A P E + + P P + ++ +++ H+
Sbjct: 318 ASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHI 377
Query: 518 AMTLLDTEQSYVESLRTLMQGYM-QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL- 575
A LL TE++YV L L Q + + L++ N +V IF I + H+QFL
Sbjct: 378 ANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLL 437
Query: 576 EQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKF 635
++ M+ W ++G +L + + +Y Y+ NF A + V E F
Sbjct: 438 PELEKRMEEWDRYPRIGDILQKLAP---FLKMYGEYVKNFDRAVELVNTWTERSTQFKVI 494
Query: 636 LEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQV 694
+ + +E L M++PVQRIPRYELL+KD L P PD +AQ++++ +
Sbjct: 495 IHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSK---DAQKSLELI 551
Query: 695 AERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KKDR 753
A + + ER ++L+ E + G ED+ +P + +++ ++++ A G +DR
Sbjct: 552 ATAAEHSNAAIRKMERMHKLLKVYEL-LGGEEDIVSPTKELIKEGHILKLSAKNGTTQDR 610
Query: 754 SLFLFTD-LIVCTTLKRKSG 772
L LF D L+ C R G
Sbjct: 611 YLILFNDRLLYCVPRLRLLG 630
>dbj|BAB14498.1| (AK023267) unnamed protein product [Homo sapiens]
Length = 798
Score = 104 bits (256), Expect = 6e-21
Identities = 61/209 (29%), Positives = 115/209 (54%), Gaps = 5/209 (2%)
Query: 514 RKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQP--ENSVLCDPSLVDEIFDQIPELLEHH 571
R VA L TE +YV L T++Q + PL++ + P + IF IP++ + H
Sbjct: 422 RWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVH 481
Query: 572 EQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPA 631
+ + + + W + +G + ++ +SKD LV Y +++ F +K+ + ++ +P
Sbjct: 482 TKIKDDLEDLIVNWDESKSIGDIFLK-YSKD-LVKTYPPFVNFFEMSKETIIKCEKQKPR 539
Query: 632 FLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRN 690
F FL+ + + + +Q+L +L+I+PVQR+P LL+ DL KHT +++PD L +A +
Sbjct: 540 FHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGS 599
Query: 691 IKQVAERINKGVRSAEEAERHARVLQEIE 719
+K+V IN+ R E ++ V+ E++
Sbjct: 600 LKEVMTHINEDKRKTEAQKQIFDVVYEVD 628
>dbj|BAA92229.1| (AK000004) FLJ00004 protein [Homo sapiens]
Length = 698
Score = 102 bits (253), Expect = 1e-20
Identities = 82/303 (27%), Positives = 138/303 (45%), Gaps = 22/303 (7%)
Query: 465 EVPAPVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDT 524
+VP P + + P +E P +A + A S PQ + H+A LL T
Sbjct: 180 QVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQH-----SGPQKLL--HIAQELLHT 232
Query: 525 EQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL--EQVRHCM 582
E++YV+ L L Q + L P ++ IF I + H QFL E
Sbjct: 233 EETYVKRLHLLDQVFCTRLTDAG----IPPEVIMGIFSNISSIHRFHGQFLLPELKTRIT 288
Query: 583 QTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRE 642
+ W ++G +L + + +Y Y+ NF A V + P F + ++
Sbjct: 289 EEWDTNPRLGDILQKLAP---FLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVIHSIQKQ 345
Query: 643 NK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKG 701
L M++PVQR+PRYELL+KD LK P+D PD +A+R+++ ++ N
Sbjct: 346 EVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRK---DAERSLELISTAANHS 402
Query: 702 VRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KKDRSLFLFTD 760
+ + E+ ++L E+ + G ED+ P +++ + ++ A G +DR LFLF
Sbjct: 403 NAAIRKVEKMHKLL-EVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNS 461
Query: 761 LIV 763
+I+
Sbjct: 462 MIL 464
>ref|NP_004454.1| faciogenital dysplasia protein [Homo sapiens]
sp|P98174|FGD1_HUMAN PUTATIVE RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR (RHO/RAC GEF)
(FACIOGENITAL DYSPLASIA PROTEIN)
pir||A55380 faciogenital dysplasia-associated protein FGD1 - human
gb|AAA57004.1| (U11690) FGD1 [Homo sapiens]
Length = 961
Score = 102 bits (253), Expect = 1e-20
Identities = 138/560 (24%), Positives = 214/560 (37%), Gaps = 102/560 (18%)
Query: 273 KSLS-DPSRRGELAGPGFEGPGGEPIREVEPMLPPSSS-EPILVEQRAEPEEPGATRSRA 330
KSLS DP G+ P EGP P PS P+ +P+ P S
Sbjct: 113 KSLSLDP---GQSLEPHPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKP-SYL 168
Query: 331 QSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQ 390
Q R P P P R DP++ L+PR
Sbjct: 169 QMPRMPPPLEPIPPPPSRPLPADPRVGKGLAPR--------------------------- 201
Query: 391 TGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFP--TRAHPTLQAP 448
+ A PSS V P++V GP PEP+ P T P Q P
Sbjct: 202 ----AEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPGPPEPVMLPQPTSQPPVPQLP 257
Query: 449 SLEDVTKQYML-----------NLHSG--EVPAPVPVDMPCL----------------PL 479
E ++L N SG + +P + C L
Sbjct: 258 EGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPAL 317
Query: 480 AAPPSAEAKP-------------------PEAARPADEPTPASKCCSKPQVDMRK---HV 517
A+ P A A P E + + P P + ++ +++ H+
Sbjct: 318 ASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHI 377
Query: 518 AMTLLDTEQSYVESLRTLMQGYM-QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL- 575
A LL TE++YV L L Q + + L++ N +V IF I + H+QFL
Sbjct: 378 ANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLL 437
Query: 576 EQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKF 635
++ M+ W ++G +L + + +Y Y+ NF A + V E F
Sbjct: 438 PELEKRMEEWDRYPRIGDILQKLAP---FLKMYGEYVKNFDRAVELVNTWTERSTQFKVI 494
Query: 636 LEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQV 694
+ + +E L M++PVQRIPRYELL+KD L P PD +AQ++++ +
Sbjct: 495 IHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSK---DAQKSLELI 551
Query: 695 AERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KKDR 753
A + + ER ++L+ E + G ED+ +P + +++ ++++ A G +DR
Sbjct: 552 ATAAEHSNAAIRKMERMHKLLKVYEL-LGGEEDIVSPTKELIKEGHILKLSAKNGTTQDR 610
Query: 754 SLFLFTD-LIVCTTLKRKSG 772
L LF D L+ C R G
Sbjct: 611 YLILFNDRLLYCVPRLRLLG 630
>ref|NP_056574.1| faciogenital dysplasia homolog 3 [Mus musculus]
gb|AAC35431.1| (AF017369) faciogenital dysplasia protein 3 [Mus musculus]
Length = 733
Score = 101 bits (249), Expect = 4e-20
Identities = 85/336 (25%), Positives = 143/336 (42%), Gaps = 30/336 (8%)
Query: 445 LQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAP--PSAEAKPPEAARPADEPTPA 502
+ +PS ++ + S P+P + +P + P + E + +EP P
Sbjct: 74 IDSPSSSVASENFPCEESSEGSPSPAILGLPSETASDSRVPQDNPQEEEDSGVGEEPDPK 133
Query: 503 SKC-----------CSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVL 551
CS PQ + H+A LL TE++YV+ L L Q + L + +
Sbjct: 134 VTLFRPQEDVSLTQCSDPQKLL--HIAQELLHTEEAYVKRLHLLDQVFCTKLTEAGIPL- 190
Query: 552 CDPSLVDEIFDQIPELLEHHEQFL--EQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYS 609
+ IF I + H QFL E + + W ++G +L + + +Y
Sbjct: 191 ---EVTTGIFSNISSIYRFHGQFLLPELQKRITEEWDTNPRLGDILQKLAP---FLKMYG 244
Query: 610 AYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVK 668
Y+ NF A V + P F + ++ L M++PVQR+PRYELL+K
Sbjct: 245 EYVKNFDRAMGLVSTWTQRSPQFKDVIHTIQKQEVCGNLTLQHHMLEPVQRVPRYELLLK 304
Query: 669 DLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDL 728
D LK P D PD + I A+ N +R E+ + L E+ + G ED+
Sbjct: 305 DYLKRLPRDAPDRKDAERSLELISTAADHSNAAIRKMEKMHK----LLEVYEQLGGEEDI 360
Query: 729 QAPLRRFLRQEMVIEVKAIGG-KKDRSLFLFTDLIV 763
P +++ + ++ A G +DR LFLF ++++
Sbjct: 361 VNPANELIKEGSIQKLSAKNGTTQDRHLFLFNNVML 396
>pir||A59235 unconventional myosin heavy chain MyoM - slime mold (Dictyostelium
discoideum)
gb|AAD47903.1|AF090533_1 (AF090533) unconventional myosin heavy chain MyoM [Dictyostelium
discoideum]
dbj|BAA84604.1| (AB017910) myoM [Dictyostelium discoideum]
Length = 1737
Score = 99.5 bits (244), Expect = 2e-19
Identities = 78/293 (26%), Positives = 139/293 (46%), Gaps = 25/293 (8%)
Query: 521 LLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRH 580
L++TE+ YV L +++ ++ P+++ + L ++ +F I L + L+ +
Sbjct: 1397 LIETERDYVRDLNIVVEVFLNPIREKQ---LLSAKDINSLFSNIEILFSINMNVLKALEK 1453
Query: 581 CMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSM 640
VG + + +Y+ Y N NA + K F ++LE M
Sbjct: 1454 DKDPLCENISVGQTFLDMSH---YLKMYTTYCSNQQNALKILEEEKIKNQPFREYLEFCM 1510
Query: 641 RENKEKQA-LSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERIN 699
++ + L+ +IKPVQRI +Y LL+K+ +K TP DHPD P L E + I + + IN
Sbjct: 1511 NDSVCRGLPLNSFIIKPVQRICKYPLLIKETIKFTPNDHPDKPALEEVDKKISDIVQSIN 1570
Query: 700 KGVRSAEEAERHARVLQEIEAHIEGMED--LQAPLRRFLRQEMVIEVKAIGGKK--DRSL 755
+ R+ E ++ + +++ I+G+ED L R L + V VK + + R+L
Sbjct: 1571 EAKRTLELFQK----IVDLQNSIDGLEDTNLMEQGRTLLMEGTVSAVKELNSEDSLSRTL 1626
Query: 756 FLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADII 808
FLF +LI+ + + L TA + T K K+ K+P+ D+ +I
Sbjct: 1627 FLFNNLILICSF---------GTNVLSTAINQFKT-KKLKLKAKIPISDSRLI 1669
>pir||TVHUA2 bcr (breakpoint cluster region) protein, splice form 3 - human
(fragment)
Length = 693
Score = 99.5 bits (244), Expect = 2e-19
Identities = 65/199 (32%), Positives = 105/199 (52%), Gaps = 13/199 (6%)
Query: 513 MRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIFDQIPELLEH 570
+RK V +L +E++Y+ L L+ M+PLK + + ++ IF ++PEL E
Sbjct: 498 VRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQQIETIFFKVPELYEI 556
Query: 571 HEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARP 630
H++F + + +Q W QQ+VG L + S+ + +Y A++DN+ A + +A
Sbjct: 557 HKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANA 613
Query: 631 AFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPL 683
F + E R NK+ K +L L+ KPV R+ R L++ DLLKHT HPDHPL
Sbjct: 614 QFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTGASHPDHPL 673
Query: 684 LLEAQRNIKQVAERINKGV 702
L +A R + IN+ +
Sbjct: 674 LQDALRISQNFLSSINEEI 692
>dbj|BAA92600.1| (AB037783) KIAA1362 protein [Homo sapiens]
Length = 699
Score = 98.7 bits (242), Expect = 3e-19
Identities = 88/345 (25%), Positives = 157/345 (45%), Gaps = 23/345 (6%)
Query: 516 HVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQI----PELLEHH 571
H+A ++ +E+ +V+ L+ L + + L P + D I +QI P+L E +
Sbjct: 206 HIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQ-LGKPVIEDRILNQILYYLPQLYELN 264
Query: 572 EQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPA 631
L+++ M W QQ++ + V+ K + +YS YI F + + P
Sbjct: 265 RDLLKELEERMLHWTEQQRIADIFVK---KGPYLKMYSTYIKEFDKNIALLDEQCKKNPG 321
Query: 632 FLKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRN 690
F + + M AL ++KPVQRIP+Y LL+ D LK+ ED D+ +A
Sbjct: 322 FAAVVREFEMSPCCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAV 381
Query: 691 IKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGK 750
+ +VA N ++ + ++ L +I+ + G ++ P R FL++ +++++
Sbjct: 382 VIEVANHANDTMKQGDNFQK----LMQIQYSLNGHHEIVQPGRVFLKEGILMKLSR-KVM 436
Query: 751 KDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKG 810
+ R FLF D ++ TT + + +SL T Y+ K+ + I
Sbjct: 437 QPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILS 496
Query: 811 ASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGF-PHQSLDDA 854
AS AT R+ +AISR E+ + + F P +SLD+A
Sbjct: 497 ASSATERDEWLEAISRAIEEYA--------KKRITFCPSRSLDEA 533
>gb|AAC27698.1| (AF038388) actin-filament binding protein Frabin [Rattus
norvegicus]
Length = 766
Score = 95.6 bits (234), Expect = 2e-18
Identities = 69/250 (27%), Positives = 118/250 (46%), Gaps = 10/250 (4%)
Query: 517 VAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL- 575
+A LL TE++YV L L Q + L + N +V++IF I + H +FL
Sbjct: 210 IATELLLTERAYVSRLNLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLL 269
Query: 576 EQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKF 635
++ MQ W ++G +L + + +Y Y+ F NA + V+ E P F
Sbjct: 270 PELEKRMQEWETTPRIGDILQKLAP---FLKMYGEYVKGFDNAVELVKNMTERVPQFKSV 326
Query: 636 LEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQV 694
E+ ++ L M++P+QRIPRYE+L+KD LK D PD ++ I
Sbjct: 327 TEEIQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDAPDWNDAKKSLEIISTA 386
Query: 695 AERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIG-GKKDR 753
A N +R E ++ L EI + ED+ P +++ ++++ A ++R
Sbjct: 387 ASHSNSAIRKMENLKK----LLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQER 442
Query: 754 SLFLFTDLIV 763
LFLF ++++
Sbjct: 443 YLFLFNNMLL 452
>gb|AAC35432.1| (AF017370) faciogenital dysplasia protein [Danio rerio]
Length = 621
Score = 94.4 bits (231), Expect = 5e-18
Identities = 74/253 (29%), Positives = 121/253 (47%), Gaps = 17/253 (6%)
Query: 516 HVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL 575
++A LL TE++YV+ L L Q + L E + D ++ IF I + H+QFL
Sbjct: 165 NIAKELLQTEEAYVKRLNLLDQVFCARLT--EAGIPTD--VITGIFSNISCIHRFHQQFL 220
Query: 576 EQVRHCM--QTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFL 633
H Q W ++G +L + + +Y Y+ NF + + V + + F
Sbjct: 221 LPELHTRITQEWSCNPRIGDILQKLAP---FLKMYGEYVKNFDRSMELVSLWTQRSGTF- 276
Query: 634 KFLEQSMRENKE--KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNI 691
K QS+++ + L M++PVQRIPRYELL+KD LK PE DH A I
Sbjct: 277 KSTVQSIQKQEVCGNLTLQHHMLEPVQRIPRYELLLKDYLKKLPEGAADHRDAQNALELI 336
Query: 692 KQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGK- 750
A N +R E+ + L E+ + G ED+ P +++ + ++ A G
Sbjct: 337 STAANHSNAAIRKMEKMHK----LLEVYERLGGEEDIVNPANELIKEGHIKKMSAKNGSA 392
Query: 751 KDRSLFLFTDLIV 763
+DR L+LF ++++
Sbjct: 393 QDRYLYLFNNMVL 405
>ref|NP_036586.1| T-cell lymphoma invasion and metastasis 2 [Homo sapiens]
gb|AAF05900.1|AF120323_1 (AF120323) T-cell lymphoma invasion and metastasis 2 [Homo sapiens]
Length = 1077
Score = 93.6 bits (229), Expect = 9e-18
Identities = 85/364 (23%), Positives = 153/364 (41%), Gaps = 29/364 (7%)
Query: 485 AEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLK 544
++A E R +P P D + V L+DTE+SYV+ L L + Y++PL
Sbjct: 447 SQANGMEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPL- 505
Query: 545 QPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVL 604
+N ++ +F +PE+LE + FLE + + A L S + +L
Sbjct: 506 --QNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGIS---ASSDFNTLETPSQFRKLL 560
Query: 605 VNI-------------YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSD 651
++ YS + N + + + AK + AF FL+ + L
Sbjct: 561 FSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDK-AFKAFLDARNPTKQHSSTLES 619
Query: 652 LMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERH 711
+IKPVQR+ +Y LL+K+L+ T ++ +H L EA + +++VA IN+ + E+ +
Sbjct: 620 YLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYED---Y 676
Query: 712 ARVLQEIEAHIEGMED--LQAPLRRFLRQEMVIEVK---AIG-GKKDRSLFLFTDLIVCT 765
V ++ A G E + + L V + ++G +KD L +F
Sbjct: 677 GTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVI 736
Query: 766 TLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAIS 825
+ +++ L++ S A +K W +P+ + G T +I + I
Sbjct: 737 LVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIH 796
Query: 826 RLDE 829
E
Sbjct: 797 TKSE 800
>pir||T34566 hypothetical protein DKFZp434L1072.1 - human (fragment)
emb|CAB59259.1| (AL122086) hypothetical protein [Homo sapiens]
Length = 1046
Score = 93.6 bits (229), Expect = 9e-18
Identities = 85/364 (23%), Positives = 153/364 (41%), Gaps = 29/364 (7%)
Query: 485 AEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLK 544
++A E R +P P D + V L+DTE+SYV+ L L + Y++PL
Sbjct: 416 SQANGMEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPL- 474
Query: 545 QPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVL 604
+N ++ +F +PE+LE + FLE + + A L S + +L
Sbjct: 475 --QNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGIS---ASSDFNTLETPSQFRKLL 529
Query: 605 VNI-------------YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSD 651
++ YS + N + + + AK + AF FL+ + L
Sbjct: 530 FSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDK-AFKAFLDARNPTKQHSSTLES 588
Query: 652 LMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERH 711
+IKPVQR+ +Y LL+K+L+ T ++ +H L EA + +++VA IN+ + E+ +
Sbjct: 589 YLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYED---Y 645
Query: 712 ARVLQEIEAHIEGMED--LQAPLRRFLRQEMVIEVK---AIG-GKKDRSLFLFTDLIVCT 765
V ++ A G E + + L V + ++G +KD L +F
Sbjct: 646 GTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVI 705
Query: 766 TLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAIS 825
+ +++ L++ S A +K W +P+ + G T +I + I
Sbjct: 706 LVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIH 765
Query: 826 RLDE 829
E
Sbjct: 766 TKSE 769
>emb|CAB62513.3| (AL035106) dJ998C11.1 (KIAA1415 protein (contains a RhoGEF domain))
[Homo sapiens]
Length = 1028
Score = 93.2 bits (228), Expect = 1e-17
Identities = 69/226 (30%), Positives = 115/226 (50%), Gaps = 20/226 (8%)
Query: 557 VDEIFDQIPELLEHHEQFLEQVRHCMQTW-HAQQKVGALLVQSFSKDVLVNIYSAYIDNF 615
V +F I ++LE H+ FL + +C+ +Q ++G + ++ K + Y +
Sbjct: 23 VKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDK------FCVYEEYC 76
Query: 616 LNAKDAVRVAKEAR--PAFLKFLEQSMRENKEKQA---LSDLMIKPVQRIPRYELLVKDL 670
N + A+R+ E P FL M K L ++ P+QRI +Y LL+K+L
Sbjct: 77 SNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKEL 136
Query: 671 LKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGME--DL 728
K TP HPDHP + A + +K V IN+ R E+ E L+++++HIEG E +L
Sbjct: 137 AKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLE----ALEQLQSHIEGWEGSNL 192
Query: 729 QAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIV-CTTLKRKSGS 773
+ L Q ++++ A G ++R+ FLF +L+V C R +GS
Sbjct: 193 TDICTQLLLQGTLLKISA-GNIQERAFFLFDNLLVYCKRKSRVTGS 237
>ref|XP_009741.2| intersectin 1 (SH3 domain protein) [Homo sapiens]
Length = 1754
Score = 93.2 bits (228), Expect = 1e-17
Identities = 77/307 (25%), Positives = 147/307 (47%), Gaps = 35/307 (11%)
Query: 489 PPEAARPADEPTPASKCCSK--------PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM 540
P + + P+ + CS P R+ L+ TE++YV L+ + + +
Sbjct: 1238 PSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQ 1297
Query: 541 QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS 600
+PL + E L V IF EL+ + + L+ +R ++ + +K+ ++
Sbjct: 1298 KPLMESE---LLTEKEVAMIFVNWKELIMCNIKLLKALR--VRKKMSGEKMPVKMIGDIL 1352
Query: 601 KDVLVNI--YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEK-QALSDLMIKPV 657
L ++ Y + LN ++ + P F +F+++ + + K LS ++KP+
Sbjct: 1353 SAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPM 1412
Query: 658 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 717
QR+ RY L++K++L++TPE+HPDH L A +++ ++N+GVR E ++R L+
Sbjct: 1413 QRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDR----LEW 1468
Query: 718 IEAHIEGMEDLQAPL-----------RRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTT 766
I+AH++ E L L R+FL + + K+ K+ FLF D ++ T
Sbjct: 1469 IQAHVQ-CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKS---NKELYGFLFNDFLLLTQ 1524
Query: 767 LKRKSGS 773
+ + GS
Sbjct: 1525 ITKPLGS 1531
>gb|AAD29952.1|AF114487_1 (AF114487) intersectin long isoform [Homo sapiens]
Length = 1721
Score = 93.2 bits (228), Expect = 1e-17
Identities = 77/307 (25%), Positives = 147/307 (47%), Gaps = 35/307 (11%)
Query: 489 PPEAARPADEPTPASKCCSK--------PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM 540
P + + P+ + CS P R+ L+ TE++YV L+ + + +
Sbjct: 1205 PSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQ 1264
Query: 541 QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS 600
+PL + E L V IF EL+ + + L+ +R ++ + +K+ ++
Sbjct: 1265 KPLMESE---LLTEKEVAMIFVNWKELIMCNIKLLKALR--VRKKMSGEKMPVKMIGDIL 1319
Query: 601 KDVLVNI--YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEK-QALSDLMIKPV 657
L ++ Y + LN ++ + P F +F+++ + + K LS ++KP+
Sbjct: 1320 SAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPM 1379
Query: 658 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 717
QR+ RY L++K++L++TPE+HPDH L A +++ ++N+GVR E ++R L+
Sbjct: 1380 QRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDR----LEW 1435
Query: 718 IEAHIEGMEDLQAPL-----------RRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTT 766
I+AH++ E L L R+FL + + K+ K+ FLF D ++ T
Sbjct: 1436 IQAHVQ-CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKS---NKELYGFLFNDFLLLTQ 1491
Query: 767 LKRKSGS 773
+ + GS
Sbjct: 1492 ITKPLGS 1498
>gb|AAF50584.1| (AE003559) CG8606 gene product [Drosophila melanogaster]
gb|AAG18329.1|AF255674_1 (AF255674) rho guanine nucleotide exchange factor 4 [Drosophila
melanogaster]
Length = 647
Score = 92.8 bits (227), Expect = 2e-17
Identities = 68/264 (25%), Positives = 130/264 (48%), Gaps = 18/264 (6%)
Query: 510 QVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLE 569
++ R+ ++ +E+SY+E L LM +++PLK+ + D S +F QI +
Sbjct: 67 RLGFRRQAIQEIISSEKSYLEQLELLMNFFVRPLKE---QAIIDCSNHTLLFGQIEMIHN 123
Query: 570 HHEQFLEQVRHCMQTW-HAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ +FL ++ M+ HA K+ +YS Y ++ A ++
Sbjct: 124 LNGEFLRELEANMENVAHAFLKMAPFF----------KLYSVYAFDYRGALFIIQDLISK 173
Query: 629 RPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQ 688
P F KFLEQ+ + ++ L+ LMI P+QR+PRY+LL++ +L +T D+ LL E+
Sbjct: 174 NPVFRKFLEQTESRPEVQRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESV 233
Query: 689 RNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIG 748
+ I+ A IN V EE E ++ + + ++ P RR +++ ++ ++ G
Sbjct: 234 KEIEATASHINTCV---EEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKG 290
Query: 749 GKKDRSLFLFTDLIV-CTTLKRKS 771
+ R L +D+ + C +K ++
Sbjct: 291 TEIKRYCVLMSDIFMYCKMIKERA 314
>gb|AAF05901.1|AF120324_1 (AF120324) T-cell lymphoma invasion and metastasis 2 short [Homo
sapiens]
Length = 626
Score = 92.4 bits (226), Expect = 2e-17
Identities = 84/358 (23%), Positives = 150/358 (41%), Gaps = 29/358 (8%)
Query: 491 EAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV 550
E R +P P D + V L+DTE+SYV+ L L + Y++PL +N
Sbjct: 2 EGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPL---QNET 58
Query: 551 LCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNI--- 607
++ +F +PE+LE + FLE + + A L S + +L ++
Sbjct: 59 FLTQDEMESLFGSLPEMLEFQKVFLETLEDGIS---ASSDFNTLETPSQFRKLLFSLGGS 115
Query: 608 ----------YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPV 657
YS + N + + + AK + AF FL+ + L +IKPV
Sbjct: 116 FLYYADHFKLYSGFCANHIKVQKVLERAKTDK-AFKAFLDARNPTKQHSSTLESYLIKPV 174
Query: 658 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 717
QR+ +Y LL+K+L+ T ++ +H L EA + +++VA IN+ + E+ + V +
Sbjct: 175 QRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYED---YGTVFDQ 231
Query: 718 IEAHIEGMED--LQAPLRRFLRQEMVIEVK---AIG-GKKDRSLFLFTDLIVCTTLKRKS 771
+ A G E + + L V + ++G +KD L +F + +++
Sbjct: 232 LVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKEN 291
Query: 772 GSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDE 829
L++ S A +K W +P+ + G T +I + I E
Sbjct: 292 CKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSE 349
>ref|NP_003015.1| intersectin 1 (SH3 domain protein); intersectin (SH3 domain protein
1A); SH3 domain protein-1A; human intersectin-SH3
domain-containing protein SH3P17 [Homo sapiens]
gb|AAC78611.1| (AF064244) intersectin long form [Homo sapiens]
Length = 1721
Score = 92.4 bits (226), Expect = 2e-17
Identities = 77/307 (25%), Positives = 146/307 (47%), Gaps = 35/307 (11%)
Query: 489 PPEAARPADEPTPASKCCSK--------PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM 540
P + + P+ + CS P R+ L+ TE++YV L+ + + +
Sbjct: 1205 PSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQ 1264
Query: 541 QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS 600
+PL + E L V IF EL+ + + L+ +R ++ + +K+ ++
Sbjct: 1265 KPLMESE---LLTEKEVAMIFVNWKELIMCNIKLLKALR--VRKKMSGEKMPVKMIGDIL 1319
Query: 601 KDVLVNI--YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEK-QALSDLMIKPV 657
L ++ Y + LN ++ + P F +F+++ + + K LS ++KP+
Sbjct: 1320 SAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLEMDPRCKGMPLSSFILKPM 1379
Query: 658 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 717
QR+ RY L++K++L++TPE+HPDH L A +++ ++N+GVR E ++R L+
Sbjct: 1380 QRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDR----LEW 1435
Query: 718 IEAHIEGMEDLQAPL-----------RRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTT 766
I+AH++ E L L R+FL + + K K+ FLF D ++ T
Sbjct: 1436 IQAHVQ-CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAK---NNKELYGFLFNDFLLLTQ 1491
Query: 767 LKRKSGS 773
+ + GS
Sbjct: 1492 ITKPLGS 1498
>ref|NP_034717.1| intersectin (SH3 domain protein 1A); intersection (SH3 domain protein
1A); Eh domain, SH3 domain regulator of endocytosis 1
[Mus musculus]
gb|AAD19749.1| (AF132481) Ese1L protein [Mus musculus]
Length = 1714
Score = 92.1 bits (225), Expect = 3e-17
Identities = 77/307 (25%), Positives = 147/307 (47%), Gaps = 35/307 (11%)
Query: 489 PPEAARPADEPTPASKCCSK--------PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM 540
P + + P+ + CS P R+ L+ TE++YV L+ + + +
Sbjct: 1198 PSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQ 1257
Query: 541 QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS 600
+PL + E L V IF EL+ + + L+ +R ++ + +K+ ++
Sbjct: 1258 KPLTESE---LLTEKEVAMIFVNWKELIMCNIKLLKALR--VRKKMSGEKMPVKMIGDIL 1312
Query: 601 KDVLVNI--YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEK-QALSDLMIKPV 657
L ++ Y + LN ++ + P F +F+++ + + K LS ++KP+
Sbjct: 1313 SAQLPHMQPYIRFCSCQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPM 1372
Query: 658 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 717
QR+ RY L++K++L++TPE+HPDH L A +++ ++N+GVR E ++R L+
Sbjct: 1373 QRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDR----LEW 1428
Query: 718 IEAHIEGMEDLQAPL-----------RRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTT 766
I+AH++ E L L R+FL + + K+ K+ FLF D ++ T
Sbjct: 1429 IQAHVQ-CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKS---NKELYGFLFNDFLLLTQ 1484
Query: 767 LKRKSGS 773
+ + GS
Sbjct: 1485 ITKPLGS 1491
>ref|NP_036008.1| RAS-related C3 botulinum substrate 1, guanine nucleotide exchange
factor 1 [Mus musculus]
dbj|BAA81823.1| (AB022915) sif and Tiam1-like exchange factor [Mus musculus]
Length = 1715
Score = 90.5 bits (221), Expect = 8e-17
Identities = 83/358 (23%), Positives = 150/358 (41%), Gaps = 29/358 (8%)
Query: 491 EAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV 550
EA + +P P D + V L+DTE+SYV+ L L + Y++PL +N
Sbjct: 1098 EAPTESHDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPL---QNET 1154
Query: 551 LCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNI--- 607
++ +F +PE+LE + FLE + + A L S + +L ++
Sbjct: 1155 FLTQDEMESLFGSLPEMLEFQKVFLETLEDAIS---ASSDFSVLETPSQFRKLLFSLGGS 1211
Query: 608 ----------YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPV 657
YS + N + + + AK + AF FL+ + L +IKPV
Sbjct: 1212 FLYYADHFKLYSGFCANHIKVQRVLERAKTDK-AFKAFLDARNPTKQHSSTLESYLIKPV 1270
Query: 658 QRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQE 717
QR+ +Y LL+K+L+ T + +H L EA + +++VA IN+ + E+ + V +
Sbjct: 1271 QRVLKYPLLLKELVSLTDHESEEHYHLTEALKAMEKVASHINEMQKIYED---YGMVFDQ 1327
Query: 718 IEAHIEGMED--LQAPLRRFLRQEMVIEVK---AIG-GKKDRSLFLFTDLIVCTTLKRKS 771
+ A G E + + L V + ++G +KD L +F + +++
Sbjct: 1328 LVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDIELTVFVFKRAVILVYKEN 1387
Query: 772 GSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDE 829
L++ S A +K W +P+ + G + T + + I E
Sbjct: 1388 CKLKKKLPSNSRPAHNSADLDPFKFRWLIPISALQVRLGNTAGTENNSTWELIHTKSE 1445
>ref|NP_006104.2| vav 3 oncogene [Homo sapiens]
gb|AAC79695.1| (AF067817) VAV-3 protein [Homo sapiens]
Length = 847
Score = 90.5 bits (221), Expect = 8e-17
Identities = 74/269 (27%), Positives = 137/269 (50%), Gaps = 28/269 (10%)
Query: 509 PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELL 568
P+ D+R + TE+ Y E+L ++ + +M PLK+ + D +F IPEL+
Sbjct: 188 PENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR-----FLTAAEFDSVFINIPELV 242
Query: 569 EHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ H ++++ + + Q + + + + V+ Y + +++ +++ D + +KE
Sbjct: 243 KLHRNLMQEIHDSIVNKN-DQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKE- 300
Query: 629 RPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT--PEDHPDHPLLLE 686
LK E S R N K L DL++ P+QR+ +Y LL+++L+KHT P + + L L+
Sbjct: 301 -DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALD 359
Query: 687 AQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKA 746
A +K +A+ +N E +R L+EI+ +E+L P+ F R + E++
Sbjct: 360 A---MKDLAQYVN-------EVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRI 409
Query: 747 I----GGKKDRSLFLF-TDLIVCTTLKRK 770
K++R +FLF +IVC KRK
Sbjct: 410 TTLDKHTKQERHIFLFDLAVIVC---KRK 435
>sp|Q9UKW4|VAV3_HUMAN VAV-3 PROTEIN
gb|AAD20349.1| (AF118887) VAV-3 protein [Homo sapiens]
Length = 847
Score = 90.1 bits (220), Expect = 1e-16
Identities = 74/269 (27%), Positives = 136/269 (50%), Gaps = 28/269 (10%)
Query: 509 PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELL 568
P+ D+R + TE+ Y E+L ++ + +M PLK+ + D +F IPEL+
Sbjct: 188 PENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR-----FLTAAEFDSVFINIPELV 242
Query: 569 EHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ H ++++ + + Q + + + + V+ Y + +++ +++ D + KE
Sbjct: 243 KLHRNLMQEIHDSIVNKN-DQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE- 300
Query: 629 RPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT--PEDHPDHPLLLE 686
LK E S R N K L DL++ P+QR+ +Y LL+++L+KHT P + + L L+
Sbjct: 301 -DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALD 359
Query: 687 AQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKA 746
A +K +A+ +N E +R L+EI+ +E+L P+ F R + E++
Sbjct: 360 A---MKDLAQYVN-------EVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRI 409
Query: 747 I----GGKKDRSLFLF-TDLIVCTTLKRK 770
K++R +FLF +IVC KRK
Sbjct: 410 TTLDKHTKQERHIFLFDLAVIVC---KRK 435
>gb|AAD20348.1| (AF118886) VAV-3 protein beta isoform [Homo sapiens]
Length = 753
Score = 90.1 bits (220), Expect = 1e-16
Identities = 76/270 (28%), Positives = 137/270 (50%), Gaps = 30/270 (11%)
Query: 509 PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELL 568
P+ D+R + TE+ Y E+L ++ + +M PLK+ + D +F IPEL+
Sbjct: 94 PENDIRSCCLAEIKQTEEKYTETLESIEKHFMAPLKR-----FLTAAEFDSVFINIPELV 148
Query: 569 EHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ H ++++ + + Q + + + + V+ Y + +++ +++ D + KE
Sbjct: 149 KLHRNLMQEIHDSIVNKN-DQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE- 206
Query: 629 RPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT--PEDHPDHPLLLE 686
LK E S R N K L DL++ P+QR+ +Y LL+++L+KHT P + + L L+
Sbjct: 207 -DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALD 265
Query: 687 AQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKA 746
A +K +A+ +N E +R L+EI+ +E+L P+ F R + E++
Sbjct: 266 A---MKDLAQYVN-------EVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRI 315
Query: 747 I----GGKKDRSLFLFTDL--IVCTTLKRK 770
K++R +FLF DL IVC KRK
Sbjct: 316 TTLDKHTKQERHIFLF-DLAAIVC---KRK 341
>pir||T34428 hypothetical protein F55C7.7d - Caenorhabditis elegans
gb|AAC71111.1| (U80436) F55C7.7d gene product [Caenorhabditis elegans]
Length = 552
Score = 89.3 bits (218), Expect = 2e-16
Identities = 92/323 (28%), Positives = 145/323 (44%), Gaps = 35/323 (10%)
Query: 363 RLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPEP- 421
R+ SK+R A ++ + + Q+ S S ++ H +S A + EP
Sbjct: 16 RIFANSSKERAAAANSSSSNNNSPATRQSTSTSSPVTANGHTTESSTSAPIGVLSSGEPT 75
Query: 422 -----PTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPC 476
P+S P VP + P P + A ED + L + +D
Sbjct: 76 SSNSIPSSSTPTHTVPSSV--PATVIPIVVA---EDEKAEDCLPPPMENITINNSIDEKD 130
Query: 477 LPLAAPPSAEAKPPEAARPAD-EPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTL 535
+ + +++A PE A PA E TP K R +V M L++TEQ YV+ L ++
Sbjct: 131 MNEDSVAASDAVEPEVALPAKVEKTPEETARFK-----RSYVLMELVETEQDYVKDLTSV 185
Query: 536 MQGYMQPLKQPENSVLCDPSLVDE---IFDQIPELLEHHE-QFLEQVRHCMQTWHAQQKV 591
++GY+ L N + LV + IF I +LE H+ FL+++ C + + A
Sbjct: 186 VEGYIGNL----NKMDLPADLVGKDKIIFANIVNILEFHKTNFLKEIEKCSENYEA---A 238
Query: 592 GALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSD 651
GA V+ + L +Y Y N K +A++ F F + + K AL D
Sbjct: 239 GAAFVKYERR--LHTLYVTYCQN--KPKSDYLLAQDD---FEAFFADTKAKLGHKVALCD 291
Query: 652 LMIKPVQRIPRYELLVKDLLKHT 674
L+IKPVQRI +Y+LL+KD+LK T
Sbjct: 292 LLIKPVQRIMKYQLLLKDILKFT 314
>pir||T34426 hypothetical protein F55C7.7c - Caenorhabditis elegans
gb|AAC71110.1| (U80436) F55C7.7c gene product [Caenorhabditis elegans]
Length = 928
Score = 89.3 bits (218), Expect = 2e-16
Identities = 92/323 (28%), Positives = 145/323 (44%), Gaps = 35/323 (10%)
Query: 363 RLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPEP- 421
R+ SK+R A ++ + + Q+ S S ++ H +S A + EP
Sbjct: 102 RIFANSSKERAAAANSSSSNNNSPATRQSTSTSSPVTANGHTTESSTSAPIGVLSSGEPT 161
Query: 422 -----PTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPC 476
P+S P VP + P P + A ED + L + +D
Sbjct: 162 SSNSIPSSSTPTHTVPSSV--PATVIPIVVA---EDEKAEDCLPPPMENITINNSIDEKD 216
Query: 477 LPLAAPPSAEAKPPEAARPAD-EPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTL 535
+ + +++A PE A PA E TP K R +V M L++TEQ YV+ L ++
Sbjct: 217 MNEDSVAASDAVEPEVALPAKVEKTPEETARFK-----RSYVLMELVETEQDYVKDLTSV 271
Query: 536 MQGYMQPLKQPENSVLCDPSLVDE---IFDQIPELLEHHE-QFLEQVRHCMQTWHAQQKV 591
++GY+ L N + LV + IF I +LE H+ FL+++ C + + A
Sbjct: 272 VEGYIGNL----NKMDLPADLVGKDKIIFANIVNILEFHKTNFLKEIEKCSENYEA---A 324
Query: 592 GALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSD 651
GA V+ + L +Y Y N K +A++ F F + + K AL D
Sbjct: 325 GAAFVKYERR--LHTLYVTYCQN--KPKSDYLLAQDD---FEAFFADTKAKLGHKVALCD 377
Query: 652 LMIKPVQRIPRYELLVKDLLKHT 674
L+IKPVQRI +Y+LL+KD+LK T
Sbjct: 378 LLIKPVQRIMKYQLLLKDILKFT 400
Database: nr
Posted date: Mar 17, 2001 4:54 PM
Number of letters in database: 202,976,666
Number of sequences in database: 644,068
Lambda K H
0.313 0.131 0.379
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 397674036
Number of Sequences: 644068
Number of extensions: 18814032
Number of successful extensions: 76900
Number of sequences better than 10.0: 1376
Number of HSP's better than 10.0 without gapping: 222
Number of HSP's successfully gapped in prelim test: 1234
Number of HSP's that attempted gapping in prelim test: 65276
Number of HSP's gapped (non-prelim): 6991
length of query: 933
length of database: 202,976,666
effective HSP length: 62
effective length of query: 871
effective length of database: 163,044,450
effective search space: 142011715950
effective search space used: 142011715950
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (21.9 bits)
S2: 76 (34.0 bits)
