Score E
Sequences producing significant alignments: (bits) Value
ref|XP_008288.1| KIAA0672 gene product [Homo sapiens] 511 e-144
ref|NP_055674.1| KIAA0672 gene product [Homo sapiens] >gi|3... 511 e-144
ref|NP_071580.1| nadrin; neuron-specific GTPase activating ... 325 3e-88
dbj|BAB14506.1| (AK023281) unnamed protein product [Homo sa... 212 4e-54
ref|NP_061830.1| SH3-domain binding protein 1 [Homo sapiens... 130 2e-29
ref|NP_033190.1| SH3-domain binding protein 1 [Mus musculus... 122 3e-27
gb|AAF55715.1| (AE003728) CG4755 gene product [Drosophila m... 98 1e-19
ref|NP_003016.1| SH3-domain GRB2-like 1; extra 11-19 leukem... 77 2e-13
sp|O35964|SH31_RAT SH3-CONTAINING GRB2-LIKE PROTEIN 1 (SH3 ... 76 4e-13
ref|NP_038692.1| SH3 domain protein 2B; endophilin II [Mus ... 75 8e-13
gb|AAC04768.1| (AF036272) EEN-B2-L4 [Homo sapiens] 75 1e-12
ref|NP_003018.1| SH3-domain GRB2-like 3 [Homo sapiens] >gi|... 75 1e-12
ref|NP_059096.1| SH3 domain protein 2 C1; endophilin III [M... 73 4e-12
ref|NP_003017.1| SH3-domain GRB2-like 2 [Homo sapiens] >gi|... 71 9e-12
ref|NP_062408.1| SH3 domain protein 2A [Mus musculus] >gi|1... 69 6e-11
gb|AAD24591.1|AC007292_1 (AC007292) SH3-containing Grb-2-li... 66 4e-10
pir||T33150 hypothetical protein T04D1.3 - Caenorhabditis e... 66 4e-10
gb|AAC04767.1| (AF036271) EEN-B2-L3 [Homo sapiens] 66 5e-10
emb|CAB92765.1| (AL139115) bA335L15.1 (SH3-domain GRB2-like... 61 1e-08
gb|AAF59636.1| (AC024755) contains similarity to TR:O75160 ... 61 1e-08
ref|XP_007752.1| SH3-domain GRB2-like 3 [Homo sapiens] 58 9e-08
gb|AAC04766.1| (AF036270) EEN-B2-L2 [Homo sapiens] 58 9e-08
gb|AAF36700.1|AF227439_1 (AF227439) SH3P13 [Rattus norvegicus] 55 6e-07
dbj|BAA22920.2| (AB008159) SH3P13S [Rattus norvegicus] 55 6e-07
gb|AAF55605.1| (AE003724) CG14296 gene product [alt 1] [Dro... 55 1e-06
gb|AAF73017.1|AF263293_1 (AF263293) endophilin B1 [Homo sap... 53 3e-06
sp|O35179|SH32_RAT SH3-CONTAINING GRB2-LIKE PROTEIN 2 (SH3 ... 53 3e-06
sp|O35180|SH33_RAT SH3-CONTAINING GRB2-LIKE PROTEIN 3 (SH3 ... 53 4e-06
ref|NP_062337.1| SH3-domain GRB2-like B1 (endophilin) [Mus ... 52 7e-06
gb|AAF81225.1|AF257318_1 (AF257318) SH3-containing protein ... 51 1e-05
ref|NP_057093.1| CGI-61 protein [Homo sapiens] >gi|11423126... 51 1e-05
pir||T16249 hypothetical protein F35A5.8 - Caenorhabditis e... 48 1e-04
pir||T39801 hypothetical sh3-containing protein - fission y... 47 2e-04
ref|NP_064530.1| SH3-containing protein SH3GLB2 [Homo sapie... 45 0.001
gb|AAD53328.1|AF078931_1 (AF078931) hydatid disease diagnos... 45 0.001
gb|AAF57578.1| (AE003796) CG9834 gene product [Drosophila m... 40 0.030
emb|CAB75944.1| (AJ245428) type I keratin Y1 [Branchiostoma... 40 0.030
gb|AAF07196.1|AF194970_1 (AF194970) LEK1 [Mus musculus] 40 0.030
ref|NP_056972.1| hook1 protein [Homo sapiens] >gi|11426993|... 40 0.030
ref|NP_071330.1| differentially expressed in FDCP (mouse ho... 39 0.039
emb|CAB65622.1| (Z97832) dJ329A5.3 (KIAA06460 protein) [Hom... 39 0.039
gb|AAF61445.1|AF139055_1 (AF139055) nonmuscle myosin heavy ... 39 0.051
dbj|BAA36494.1| (AB022023) nonmuscle myosin heavy chain B [... 39 0.067
pir||S58922 tropomyosin isoform TMII - Caenorhabditis elega... 39 0.067
sp|Q07068|TPM1_CIOIN TROPOMYOSIN, SMOOTH MUSCLE/FIBROBLAST ... 39 0.067
ref|NP_064322.1| sperm tail associated protein [Mus musculu... 38 0.088
sp|P50478|AMPH_CHICK AMPHIPHYSIN >gi|86184|pir||S22700 amph... 38 0.088
pir||T13030 microtubule binding protein D-CLIP-190 - fruit ... 38 0.11
emb|CAC10340.1| (AL139421) dJ717I23.1 (novel protein simila... 37 0.26
emb|CAB58234.1| (AJ250201) lamin B1 protein [Danio rerio] 37 0.26
>ref|XP_008288.1| KIAA0672 gene product [Homo sapiens]
Length = 818
Score = 511 bits (1302), Expect = e-144
Identities = 260/260 (100%), Positives = 260/260 (100%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA
Sbjct: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
Query: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV
Sbjct: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
Query: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR 180
IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR
Sbjct: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR 180
Query: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI
Sbjct: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
Query: 241 KAQQEAWVEKPSFGKPLEEH 260
KAQQEAWVEKPSFGKPLEEH
Sbjct: 241 KAQQEAWVEKPSFGKPLEEH 260
>ref|NP_055674.1| KIAA0672 gene product [Homo sapiens]
dbj|BAA31647.1| (AB014572) KIAA0672 protein [Homo sapiens]
Length = 818
Score = 511 bits (1302), Expect = e-144
Identities = 260/260 (100%), Positives = 260/260 (100%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA
Sbjct: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
Query: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV
Sbjct: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
Query: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR 180
IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR
Sbjct: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR 180
Query: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI
Sbjct: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
Query: 241 KAQQEAWVEKPSFGKPLEEH 260
KAQQEAWVEKPSFGKPLEEH
Sbjct: 241 KAQQEAWVEKPSFGKPLEEH 260
>ref|NP_071580.1| nadrin; neuron-specific GTPase activating protein [Rattus
norvegicus]
dbj|BAB12426.1| (AB042827) Nadrin [Rattus norvegicus]
Length = 780
Score = 325 bits (825), Expect = 3e-88
Identities = 158/260 (60%), Positives = 208/260 (79%), Gaps = 3/260 (1%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
MKKQFNRM+QLANQTVGRAEKTEVLSEDLLQ+E+RL+ V+ + H +HK+L AC QGQ G
Sbjct: 1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSMCHHSHKRLIACFQGQHGT 60
Query: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
+A++R KKLPLT LAQ + E SA L +++LLGKML+ CG+ E++LA EL E+ VE+++
Sbjct: 61 DAERRHKKLPLTALAQNMQEASAQL-EESLLGKMLETCGDAENQLAFELSQHEVFVEKEI 119
Query: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR 180
++PL+ +AEVEIPNIQKQRK LA+LVLD DS R RW Q KSSG ++ Q +K D L+
Sbjct: 120 MDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSG--TNFQGLPSKIDTLK 177
Query: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
EEM+EA N+VE C+DQL+ADMY+F+AKE +Y +F TL+E QA+YHRK+L +L+ LP++
Sbjct: 178 EEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKALPEM 237
Query: 241 KAQQEAWVEKPSFGKPLEEH 260
+A Q+ W EKP+FG PLEEH
Sbjct: 238 RAHQDKWAEKPAFGTPLEEH 257
>dbj|BAB14506.1| (AK023281) unnamed protein product [Homo sapiens]
Length = 726
Score = 212 bits (533), Expect = 4e-54
Identities = 99/174 (56%), Positives = 136/174 (77%), Gaps = 2/174 (1%)
Query: 87 DDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLV 146
+D+LLGKML+ CG+ E++LA EL E+ VE+++++PL+ +AEVEIPNIQKQRK LA+LV
Sbjct: 9 EDSLLGKMLETCGDAENQLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLV 68
Query: 147 LDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVA 206
LD DS R RW Q KSSG ++ Q +K D L+EEM+EA N+VE C+DQL+ADMY+F+A
Sbjct: 69 LDWDSVRARWNQAHKSSG--TNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMA 126
Query: 207 KEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEH 260
KE +Y +F TL+E QA+YHRK+L +L+ LP+++A Q+ W EKP+FG PL EH
Sbjct: 127 KEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLAEH 180
>ref|NP_061830.1| SH3-domain binding protein 1 [Homo sapiens]
emb|CAB42896.1| (Z83844) dJ37E16.2 (SH3-domain binding protein 1) [Homo sapiens]
Length = 616
Score = 130 bits (323), Expect = 2e-29
Identities = 71/177 (40%), Positives = 106/177 (59%), Gaps = 9/177 (5%)
Query: 85 LGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAK 144
L D+ +GK L++ +++LA+ L FE+ +ERDV++PL L+E E+P I K +K L K
Sbjct: 8 LDPDSSMGKALEMSCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQK 67
Query: 145 LVLDMDSSRTRWQQTSKSSGLSSSLQPAGA---------KADALREEMEEAANRVEICRD 195
LV D ++ ++R Q +K+SG S L + K + L+EE EE +VE CRD
Sbjct: 68 LVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHSHTTMANKVETLKEEEEELKRKVEQCRD 127
Query: 196 QLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPS 252
+ AD+Y FV KE YANYF L+E+QA+YHR+SL+ L L +++ PS
Sbjct: 128 EYLADLYHFVTKEDSYANYFIRLLEIQADYHRRSLSSLDTALAELRENHGQADHSPS 184
>ref|NP_033190.1| SH3-domain binding protein 1 [Mus musculus]
sp|P55194|3BP1_MOUSE SH3-BINDING PROTEIN 3BP-1
pir||S56144 SH3 domain binding protein - mouse
emb|CAA61011.1| (X87671) SH3 domain binding protein [Mus musculus]
Length = 601
Score = 122 bits (304), Expect = 3e-27
Identities = 67/166 (40%), Positives = 101/166 (60%), Gaps = 9/166 (5%)
Query: 85 LGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAK 144
L D+ +GK L++ +++LA+ L FE+ +ERDV++ L+E E+P I K +K L K
Sbjct: 8 LDPDSSMGKALEMTCAIQNQLARILAEFEMTLERDVLQRSGRLSEEELPAILKHKKSLQK 67
Query: 145 LVLDMDSSRTRWQQTSKSSGLSSSLQPAGA---------KADALREEMEEAANRVEICRD 195
LV D ++ ++R Q +K+SG + L A K + L+EE EE +VE C+D
Sbjct: 68 LVSDWNTLKSRLSQAAKNSGSNQGLGGASGSHTHTTTANKVEMLKEEEEELKKKVEQCKD 127
Query: 196 QLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIK 241
+ AD+Y F KE YANYF L+E+QA+YHRKSLT L L +++
Sbjct: 128 EYLADLYHFSTKEDSYANYFIHLLEIQADYHRKSLTSLDTALAELR 173
>gb|AAF55715.1| (AE003728) CG4755 gene product [Drosophila melanogaster]
Length = 740
Score = 97.9 bits (240), Expect = 1e-19
Identities = 73/266 (27%), Positives = 134/266 (49%), Gaps = 16/266 (6%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
MK+QF +++ +A + + R+ K++ +L +E++++ + +KL A L G G+
Sbjct: 1 MKRQFAKIK-IAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPA-LSGGGGS 58
Query: 61 ------EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFEL 114
E DKR+KK +AQ L E + L D L K+L CGE E +A+ +I EL
Sbjct: 59 GSGSSEEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESEL 118
Query: 115 QVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGA 174
+ E V+ L + + EI I ++++++ + + S + +S + L+ A
Sbjct: 119 ETEAKVVRRLKNILDKEIQEISTLKRNVSRTLQEYTSLK-------RSHEAAIRLEEPAA 171
Query: 175 KADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQ 234
K + ++ + EE ++E RD +A M +AKE + + + + Q YH ++L +
Sbjct: 172 KVNHIKSQQEECELKLEKERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVN 231
Query: 235 AVLPQIKAQQEAWVEKPSFGKPLEEH 260
A L +I+ + EK FG L+EH
Sbjct: 232 ASLARIQDTIQG-TEKSRFGTSLKEH 256
>ref|NP_003016.1| SH3-domain GRB2-like 1; extra 11-19 leukemia fusion gene; fusion
partner of MLL [Homo sapiens]
ref|XP_009409.1| SH3-domain GRB2-like 1 [Homo sapiens]
emb|CAA67970.1| (X99656) SH3-containing Grb-2-like 1 [Homo sapiens]
gb|AAB86800.1| (U65999) SH3-containing protein EEN [Homo sapiens]
gb|AAF04290.1|AF190465_1 (AF190465) SH3-containing protein EEN [Homo sapiens]
Length = 368
Score = 76.9 bits (186), Expect = 2e-13
Identities = 63/270 (23%), Positives = 123/270 (45%), Gaps = 43/270 (15%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVK--------------QVSHST 46
+KKQF + QL ++ VG AE T+ L +D ++EK++++ Q + ++
Sbjct: 6 LKKQFYKASQLVSEKVGGAEGTK-LDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPAS 64
Query: 47 HKKLTAC-----LQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGET 101
KLT ++GQ +S+ L L +C++ LG ++ G L GE+
Sbjct: 65 RAKLTMLNTVSKIRGQVKNPGYPQSEGL----LGECMIRHGKELGGESNFGDALLDAGES 120
Query: 102 EDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSK 161
+LA+ +++V+++ I+PL L E ++ IQ K L LD D + R
Sbjct: 121 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKR------ 174
Query: 162 SSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEV 221
G D EE+ +A + E ++ M++ + +I+ + L++
Sbjct: 175 ----------QGKIPD---EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDA 221
Query: 222 QAEYHRKSLTLLQAVLPQIKAQQEAWVEKP 251
Q +YHR+++ +L + ++K + +P
Sbjct: 222 QLDYHRQAVQILDELAEKLKRRMREASSRP 251
>sp|O35964|SH31_RAT SH3-CONTAINING GRB2-LIKE PROTEIN 1 (SH3 DOMAIN PROTEIN 2B) (SH3P8)
gb|AAC14882.1| (AF009602) SH3p8 [Rattus norvegicus]
dbj|BAA22921.1| (AB008161) SH3P8 [Rattus norvegicus]
Length = 368
Score = 76.1 bits (184), Expect = 4e-13
Identities = 62/270 (22%), Positives = 124/270 (44%), Gaps = 43/270 (15%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVK--------------QVSHST 46
+KKQF + QL ++ VG AE T+ L +D ++EK++++ Q + ++
Sbjct: 6 LKKQFYKASQLVSEKVGGAEGTK-LDDDFREMEKKVDITSKAVAEVLVRTIEYLQPNPAS 64
Query: 47 HKKLTAC-----LQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGET 101
KLT ++GQ +S+ L L +C++ LG ++ G L GE+
Sbjct: 65 RAKLTMLNTVSKIRGQVKNPGYPQSEGL----LGECMVRHGKELGGESNFGDALLDAGES 120
Query: 102 EDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSK 161
+LA+ +++V+++ I+PL L + ++ IQ K L LD D + R
Sbjct: 121 MKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKKLEGRRLDFDYKKKR------ 174
Query: 162 SSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEV 221
G D EE+ +A + E ++ M++ + +I+ + L++
Sbjct: 175 ----------QGKIPD---EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDA 221
Query: 222 QAEYHRKSLTLLQAVLPQIKAQQEAWVEKP 251
Q +YHR+++ +L+ + ++K + +P
Sbjct: 222 QLDYHRQAVQILEELADKLKRRVREASSRP 251
>ref|NP_038692.1| SH3 domain protein 2B; endophilin II [Mus musculus]
sp|Q62419|SH31_MOUSE SH3-CONTAINING GRB2-LIKE PROTEIN 1 (SH3 DOMAIN PROTEIN 2B) (SH3P8)
gb|AAC71775.1| (U58885) endophilin II [Mus musculus]
Length = 368
Score = 74.9 bits (181), Expect = 8e-13
Identities = 62/270 (22%), Positives = 123/270 (44%), Gaps = 43/270 (15%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVK--------------QVSHST 46
+KKQF + QL ++ VG AE T+ L +D +EK++++ Q + ++
Sbjct: 6 LKKQFYKASQLVSEKVGGAEGTK-LDDDFKDMEKKVDVTSKAVAEVLVRTIEYLQPNPAS 64
Query: 47 HKKLTAC-----LQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGET 101
KLT ++GQ +S+ L L +C++ LG ++ G L GE+
Sbjct: 65 RAKLTMLNTVSKIRGQVKNPGYPQSEGL----LGECMVRHGKELGGESNFGDALLDAGES 120
Query: 102 EDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSK 161
+LA+ +++V+++ I+PL L + ++ IQ K L LD D + R
Sbjct: 121 MKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKKLEGRRLDFDYKKKR------ 174
Query: 162 SSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEV 221
G D EE+ +A + E ++ M++ + +I+ + L++
Sbjct: 175 ----------QGKIPD---EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDA 221
Query: 222 QAEYHRKSLTLLQAVLPQIKAQQEAWVEKP 251
Q +YHR+++ +L+ + ++K + +P
Sbjct: 222 QLDYHRQAVQILEELADKLKRRVREASSRP 251
>gb|AAC04768.1| (AF036272) EEN-B2-L4 [Homo sapiens]
Length = 340
Score = 74.5 bits (180), Expect = 1e-12
Identities = 60/261 (22%), Positives = 115/261 (43%), Gaps = 35/261 (13%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
+KKQF++ QL ++ + AE T+ L ++ L +E+++++ +V K T LQ
Sbjct: 6 LKKQFHKASQLFSEKISGAEGTK-LDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAY 64
Query: 61 EA-------------DKRSKKLPLTT--LAQCLMEGSAILGDDTLLGKMLKLCGETEDKL 105
A ++ P T L C+++ LG+D+ G L GE+ +
Sbjct: 65 RAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLM 124
Query: 106 AQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGL 165
A+ ++ V++ I+PL LL + ++ I K L LD D + R
Sbjct: 125 AEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKR---------- 174
Query: 166 SSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEY 225
G D EE+ +A + E ++ M++F+ +++ + IE +Y
Sbjct: 175 ------VGKIPD---EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDY 225
Query: 226 HRKSLTLLQAVLPQIKAQQEA 246
HR+S +LQ + +++ + A
Sbjct: 226 HRQSTEILQELQSKLQMRISA 246
>ref|NP_003018.1| SH3-domain GRB2-like 3 [Homo sapiens]
emb|CAA67978.1| (X99664) SH3-containing Grb-2-like 3 [Homo sapiens]
gb|AAC04765.1| (AF036269) EEN-B2-L1 [Homo sapiens]
Length = 347
Score = 74.5 bits (180), Expect = 1e-12
Identities = 60/261 (22%), Positives = 115/261 (43%), Gaps = 35/261 (13%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
+KKQF++ QL ++ + AE T+ L ++ L +E+++++ +V K T LQ
Sbjct: 6 LKKQFHKASQLFSEKISGAEGTK-LDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAY 64
Query: 61 EA-------------DKRSKKLPLTT--LAQCLMEGSAILGDDTLLGKMLKLCGETEDKL 105
A ++ P T L C+++ LG+D+ G L GE+ +
Sbjct: 65 RAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLM 124
Query: 106 AQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGL 165
A+ ++ V++ I+PL LL + ++ I K L LD D + R
Sbjct: 125 AEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKR---------- 174
Query: 166 SSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEY 225
G D EE+ +A + E ++ M++F+ +++ + IE +Y
Sbjct: 175 ------VGKIPD---EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDY 225
Query: 226 HRKSLTLLQAVLPQIKAQQEA 246
HR+S +LQ + +++ + A
Sbjct: 226 HRQSTEILQELQSKLQMRISA 246
>ref|NP_059096.1| SH3 domain protein 2 C1; endophilin III [Mus musculus]
sp|Q62421|SH33_MOUSE SH3-CONTAINING GRB2-LIKE PROTEIN 3 (SH3 DOMAIN PROTEIN 2C) (SH3P13)
gb|AAC72268.1| (U58887) endophilin III [Mus musculus]
Length = 347
Score = 72.6 bits (175), Expect = 4e-12
Identities = 56/256 (21%), Positives = 111/256 (42%), Gaps = 35/256 (13%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
+KKQF++ QL ++ + AE T+ L E+ L +EK++++ + K T LQ
Sbjct: 6 LKKQFHKASQLFSEKISGAEGTK-LDEEFLNMEKKIDITSKAVAEILSKATEYLQPNPAY 64
Query: 61 EA-------------DKRSKKLPLTT--LAQCLMEGSAILGDDTLLGKMLKLCGETEDKL 105
A ++ P T L C+++ LG+D+ G L GE +
Sbjct: 65 RAKLGMLNTVSKLRGQVKATGYPQTEGLLGDCMLKYGKELGEDSAFGNSLVDVGEALKLM 124
Query: 106 AQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGL 165
A+ ++ V++ I+PL LL + ++ I + L LD D + R + +
Sbjct: 125 AEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKRRVGKIPE---- 180
Query: 166 SSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEY 225
EE+ +A + E ++ M++F+ +++ + +E +Y
Sbjct: 181 ---------------EEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDY 225
Query: 226 HRKSLTLLQAVLPQIK 241
HR+S +LQ + +++
Sbjct: 226 HRQSTEILQELQSKLE 241
>ref|NP_003017.1| SH3-domain GRB2-like 2 [Homo sapiens]
ref|XP_005469.1| SH3-domain GRB2-like 2 [Homo sapiens]
sp|Q99962|SH32_HUMAN SH3-CONTAINING GRB2-LIKE PROTEIN 2 (SH3 DOMAIN PROTEIN 2A)
(ENDOPHILIN 1) (EEN-B1)
emb|CAA67971.1| (X99657) SH3-containing Grb-2-like 2 [Homo sapiens]
gb|AAC04764.1| (AF036268) EEN-B1 [Homo sapiens]
Length = 352
Score = 71.4 bits (172), Expect = 9e-12
Identities = 58/256 (22%), Positives = 117/256 (45%), Gaps = 35/256 (13%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
+KKQF++ Q ++ VG AE T+ L +D ++E+++++ + K LQ +
Sbjct: 6 LKKQFHKATQKVSEKVGGAEGTK-LDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPAS 64
Query: 61 EAD----------KRSKKLP-----LTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKL 105
A + +K P LA+ +++ LGDD G L GE +L
Sbjct: 65 RAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMREL 124
Query: 106 AQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGL 165
++ +++V+++ I+PL L + ++ IQ K L LD D + R
Sbjct: 125 SEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKR---------- 174
Query: 166 SSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEY 225
G D EE+ +A + + ++ + M++ + +I+ + L++ Q EY
Sbjct: 175 ------QGKIPD---EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEY 225
Query: 226 HRKSLTLLQAVLPQIK 241
H++++ +LQ V +++
Sbjct: 226 HKQAVQILQQVTVRLE 241
>ref|NP_062408.1| SH3 domain protein 2A [Mus musculus]
sp|Q62420|SH32_MOUSE SH3-CONTAINING GRB2-LIKE PROTEIN 2 (SH3 DOMAIN PROTEIN 2A)
(ENDOPHILIN 1) (SH3P4)
gb|AAC71774.1| (U58886) endophilin I [Mus musculus]
Length = 352
Score = 68.7 bits (165), Expect = 6e-11
Identities = 57/256 (22%), Positives = 116/256 (45%), Gaps = 35/256 (13%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
+KKQF++ Q ++ VG AE T+ L +D ++E+++++ + K LQ +
Sbjct: 6 LKKQFHKATQKVSEKVGGAEGTK-LDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPAS 64
Query: 61 EAD----------KRSKKLP-----LTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKL 105
A + +K P LA+ +++ LGDD G L GE +L
Sbjct: 65 RAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMREL 124
Query: 106 AQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGL 165
++ +++V+++ I+PL L + ++ IQ K L LD + R
Sbjct: 125 SEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFGYKKKR---------- 174
Query: 166 SSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEY 225
G D EE+ +A + + ++ + M++ + +I+ + L++ Q EY
Sbjct: 175 ------QGKIPD---EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEY 225
Query: 226 HRKSLTLLQAVLPQIK 241
H++++ +LQ V +++
Sbjct: 226 HKQAVQILQQVTVRLE 241
>gb|AAD24591.1|AC007292_1 (AC007292) SH3-containing Grb-2-like 1 protein; SH3-containing
protein EEN [Homo sapiens]; SH3-domain GRB2-like 1
Length = 353
Score = 66.0 bits (158), Expect = 4e-10
Identities = 57/260 (21%), Positives = 116/260 (43%), Gaps = 43/260 (16%)
Query: 11 LANQTVGRAEKTEVLSEDLLQVEKRLELVK--------------QVSHSTHKKLTAC--- 53
+ ++ VG AE T+ L +D ++EK++++ Q + ++ KLT
Sbjct: 1 MVSEKVGGAEGTK-LDDDFKEMEKKVDVTSKAVTEVLARTIEYLQPNPASRAKLTMLNTV 59
Query: 54 --LQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIH 111
++GQ +S+ L L +C++ LG ++ G L GE+ +LA+
Sbjct: 60 SKIRGQVKNPGYPQSEGL----LGECMIRHGKELGGESNFGDALLDAGESMKRLAEVKDS 115
Query: 112 FELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQP 171
+++V+++ I+PL L E ++ IQ K L LD D + R
Sbjct: 116 LDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKR---------------- 159
Query: 172 AGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLT 231
G D EE+ +A + E ++ M++ + +I+ + L++ Q +YHR+++
Sbjct: 160 QGKIPD---EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQ 216
Query: 232 LLQAVLPQIKAQQEAWVEKP 251
+L + ++K + +P
Sbjct: 217 ILDELAEKLKRRMREASSRP 236
>pir||T33150 hypothetical protein T04D1.3 - Caenorhabditis elegans
gb|AAC17558.1| (AF067617) contains similarity to scr homology domain 3 (SH3)
(PFam: SH3.hmm, score: 63.24) [Caenorhabditis elegans]
Length = 443
Score = 66.0 bits (158), Expect = 4e-10
Identities = 64/274 (23%), Positives = 119/274 (43%), Gaps = 40/274 (14%)
Query: 1 MKKQFNRMRQLANQTVGRAEKT---EVLSEDLLQVEKRLELVKQVSHSTHKKL-----TA 52
++KQFN+ Q ++T+G AE T +V +E V+ L+ + T++ L T
Sbjct: 6 LRKQFNKANQYLSETMGAAEPTKLDDVFNEMEKNVDTTYNLITDLVAGTNEYLQPNPATR 65
Query: 53 CLQGQQGAEADKR----SKKLPLTT--LAQCLMEGSAILGDDTLLGKMLKLCGETEDKLA 106
Q A + R + P T LA + + LGD++ LGK L ET ++A
Sbjct: 66 AKMATQVALSKVRGTTKTSPYPQTEGMLADVMQKYGQQLGDNSDLGKSLNDAAETYRQMA 125
Query: 107 QELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLS 166
E V+++ ++PL L E+ ++ R L LD D + + ++
Sbjct: 126 DIKYQMEDNVKQNFLDPLTHLQNNELKDVNHHRTKLKGRRLDYDCKKRQQRRD------- 178
Query: 167 SSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYH 226
+EM +A ++E + M++ ++ +++ + + LIE Q ++H
Sbjct: 179 --------------DEMIQAEEKLEESKRLAEMSMFNVLSNDVEQISQLRALIEAQLDFH 224
Query: 227 RKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEH 260
R++ L+ + QQ K + +P EEH
Sbjct: 225 RQTAQCLENL-----QQQLGHRIKDAAARPREEH 253
>gb|AAC04767.1| (AF036271) EEN-B2-L3 [Homo sapiens]
Length = 355
Score = 65.6 bits (157), Expect = 5e-10
Identities = 56/253 (22%), Positives = 109/253 (42%), Gaps = 35/253 (13%)
Query: 9 RQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEA------ 62
+QL ++ + AE T+ L ++ L +E+++++ +V K T LQ A
Sbjct: 22 QQLFSEKISGAEGTK-LDDEFLDMERKIDVTNKVVAEILSKTTEYLQPNPAYRAKLGMLN 80
Query: 63 -------DKRSKKLPLTT--LAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFE 113
++ P T L C+++ LG+D+ G L GE+ +A+ +
Sbjct: 81 TVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGESMKLMAEVKDSLD 140
Query: 114 LQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAG 173
+ V++ I+PL LL + ++ I K L LD D + R G
Sbjct: 141 INVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKR----------------VG 184
Query: 174 AKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLL 233
D EE+ +A + E ++ M++F+ +++ + IE +YHR+S +L
Sbjct: 185 KIPD---EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEIL 241
Query: 234 QAVLPQIKAQQEA 246
Q + +++ + A
Sbjct: 242 QELQSKLQMRISA 254
>emb|CAB92765.1| (AL139115) bA335L15.1 (SH3-domain GRB2-like 2) [Homo sapiens]
Length = 337
Score = 60.9 bits (145), Expect = 1e-08
Identities = 53/244 (21%), Positives = 109/244 (43%), Gaps = 35/244 (14%)
Query: 13 NQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEAD--------- 63
++ VG AE T+ L +D ++E+++++ + K LQ + A
Sbjct: 3 SEKVGGAEGTK-LDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSK 61
Query: 64 -KRSKKLP-----LTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVE 117
+ +K P LA+ +++ LGDD G L GE +L++ +++V+
Sbjct: 62 IRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVK 121
Query: 118 RDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKAD 177
++ I+PL L + ++ IQ K L LD D + R G D
Sbjct: 122 QNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKR----------------QGKIPD 165
Query: 178 ALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVL 237
EE+ +A + + ++ + M++ + +I+ + L++ Q EYH++++ +LQ V
Sbjct: 166 ---EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVT 222
Query: 238 PQIK 241
+++
Sbjct: 223 VRLE 226
>gb|AAF59636.1| (AC024755) contains similarity to TR:O75160 [Caenorhabditis
elegans]
Length = 604
Score = 60.9 bits (145), Expect = 1e-08
Identities = 49/208 (23%), Positives = 94/208 (44%), Gaps = 19/208 (9%)
Query: 56 GQQGAEADKRSKKLPLTTLAQCLMEGSAILG--DDTLLGKMLKLCGETEDKLAQELIHFE 113
G + DKR KK+ T+AQ L E S L + L +++ G E + E
Sbjct: 55 GFKEENVDKRKKKVEELTMAQNLREASVDLDYFQTSCLHRVINAYGTVLHAEVDEKVKLE 114
Query: 114 LQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAG 173
+ +ER V E L +E E N+ K + L + D++ ++ + K + ++
Sbjct: 115 MAMERRVYEELAPFSEYE-KNVNKLKDKLNLVSTDLEIAQ---KDLEKENSMTH------ 164
Query: 174 AKADALREEMEEAANRVEICRDQLSADMY-SFVAKEIDYANYFQTLIEVQAEYHRKSLTL 232
+E ++ + E +D L D++ S V+KE + T + ++ +Y +K +
Sbjct: 165 ------QESLDAIQMKYEGMKDALVTDIFASSVSKEFQLNEHMLTSMNLKRDYFKKMYEM 218
Query: 233 LQAVLPQIKAQQEAWVEKPSFGKPLEEH 260
+ +P+++ + +P FG PL+EH
Sbjct: 219 YEKAIPEVERMIATALPRPVFGVPLDEH 246
>ref|XP_007752.1| SH3-domain GRB2-like 3 [Homo sapiens]
Length = 311
Score = 58.2 bits (138), Expect = 9e-08
Identities = 40/173 (23%), Positives = 77/173 (44%), Gaps = 19/173 (10%)
Query: 74 LAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIP 133
L C+++ LG+D+ G L GE+ +A+ ++ V++ I+PL LL + ++
Sbjct: 57 LGDCMLKYGKELGEDSTFGNALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLK 116
Query: 134 NIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEIC 193
I K L LD D + R G D EE+ +A + E
Sbjct: 117 EIGHHLKKLEGRRLDYDYKKKR----------------VGKIPD---EEVRQAVEKFEES 157
Query: 194 RDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEA 246
++ M++F+ +++ + IE +YHR+S +LQ + +++ + A
Sbjct: 158 KELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKLQMRISA 210
>gb|AAC04766.1| (AF036270) EEN-B2-L2 [Homo sapiens]
Length = 278
Score = 58.2 bits (138), Expect = 9e-08
Identities = 40/173 (23%), Positives = 77/173 (44%), Gaps = 19/173 (10%)
Query: 74 LAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIP 133
L C+++ LG+D+ G L GE+ +A+ ++ V++ I+PL LL + ++
Sbjct: 24 LGDCMLKYGKELGEDSTFGNALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLK 83
Query: 134 NIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEIC 193
I K L LD D + R G D EE+ +A + E
Sbjct: 84 EIGHHLKKLEGRRLDYDYKKKR----------------VGKIPD---EEVRQAVEKFEES 124
Query: 194 RDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEA 246
++ M++F+ +++ + IE +YHR+S +LQ + +++ + A
Sbjct: 125 KELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKLQMRISA 177
>gb|AAF36700.1|AF227439_1 (AF227439) SH3P13 [Rattus norvegicus]
Length = 312
Score = 55.4 bits (131), Expect = 6e-07
Identities = 40/181 (22%), Positives = 79/181 (43%), Gaps = 23/181 (12%)
Query: 54 LQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFE 113
L+GQ A +++ L L C+++ LG+D+ G L GE +A+ +
Sbjct: 42 LRGQVKATGYPQTEGL----LGDCMLKYGRELGEDSAFGNSLVEVGEALKLMAEVKDSLD 97
Query: 114 LQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAG 173
+ V++ I+PL LL + ++ I + L LD D + R + +
Sbjct: 98 INVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKKRVGKIPE------------ 145
Query: 174 AKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLL 233
EE+ +A + E ++ M++F+ +++ + +E +YHR+S +L
Sbjct: 146 -------EEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEIL 198
Query: 234 Q 234
Q
Sbjct: 199 Q 199
>dbj|BAA22920.2| (AB008159) SH3P13S [Rattus norvegicus]
Length = 278
Score = 55.4 bits (131), Expect = 6e-07
Identities = 40/181 (22%), Positives = 79/181 (43%), Gaps = 23/181 (12%)
Query: 54 LQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFE 113
L+GQ A +++ L L C+++ LG+D+ G L GE +A+ +
Sbjct: 8 LRGQVKATGYPQTEGL----LGDCMLKYGRELGEDSAFGNSLVEVGEALKLMAEVKDSLD 63
Query: 114 LQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAG 173
+ V++ I+PL LL + ++ I + L LD D + R + +
Sbjct: 64 INVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKKRVGKIPE------------ 111
Query: 174 AKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLL 233
EE+ +A + E ++ M++F+ +++ + +E +YHR+S +L
Sbjct: 112 -------EEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEIL 164
Query: 234 Q 234
Q
Sbjct: 165 Q 165
>gb|AAF55605.1| (AE003724) CG14296 gene product [alt 1] [Drosophila melanogaster]
gb|AAF55606.1| (AE003724) CG14296 gene product [alt 2] [Drosophila melanogaster]
Length = 368
Score = 54.7 bits (129), Expect = 1e-06
Identities = 52/267 (19%), Positives = 116/267 (42%), Gaps = 38/267 (14%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKR----LELVKQVSHSTHKKLT----- 51
+KKQ N+ Q + +G AE T+ L D +++E++ +ELV+++ T + L
Sbjct: 6 LKKQINKANQYMTEKMGGAEGTK-LDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTA 64
Query: 52 ----ACLQG--QQGAEADKRSKKLPLTTLAQCLMEGSAILGDD-TLLGKMLKLCGETEDK 104
A ++G + +A + P LA+C++ LG+D ++ + L GE +
Sbjct: 65 RAKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQ 124
Query: 105 LAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSG 164
+A + ++++ +EPL + ++ + RK L LD D R R
Sbjct: 125 MADVKYSLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRR--------- 175
Query: 165 LSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAE 224
AK D +R ++ +++ + M++ + + ++ + T E +
Sbjct: 176 --------QAKDDEIRGAEDKFGESLQLAQ----VGMFNLLENDTEHVSQLVTFAEALYD 223
Query: 225 YHRKSLTLLQAVLPQIKAQQEAWVEKP 251
+H + +L+ + ++ ++ +P
Sbjct: 224 FHSQCADVLRGLQETLQEKRSEAESRP 250
>gb|AAF73017.1|AF263293_1 (AF263293) endophilin B1 [Homo sapiens]
emb|CAC10394.1| (AL049597) dJ612B15.2.2 (endophilin B1 (isoform 2)) [Homo sapiens]
Length = 386
Score = 53.1 bits (125), Expect = 3e-06
Identities = 52/207 (25%), Positives = 89/207 (42%), Gaps = 20/207 (9%)
Query: 6 NRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEAD-- 63
+R Q + +G+AEKTE L L + + E K + K+ LQ A +
Sbjct: 20 SRAVQFTEEKLGQAEKTE-LDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEF 78
Query: 64 ---KRSKKLPLTT-----LAQCLMEGSAILGDDTLLGKMLKLCGETEDKLA---QELIHF 112
K +K P L Q +++ G T G L CGET+ ++ +ELI
Sbjct: 79 VYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQT 138
Query: 113 ELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPA 172
+ + PL E + I K+RK L LD+D+++TR ++ + +S L A
Sbjct: 139 SAL---NFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSQLNSA 195
Query: 173 GAKADAL---REEMEEAANRVEICRDQ 196
+ D + EE+ ++ + I + +
Sbjct: 196 RLEGDNIMIWAEEVTKSEQELRITQSE 222
>sp|O35179|SH32_RAT SH3-CONTAINING GRB2-LIKE PROTEIN 2 (SH3 DOMAIN PROTEIN 2A)
(ENDOPHILIN 1) (SH3P4)
gb|AAC14883.1| (AF009603) SH3p4 [Rattus norvegicus]
Length = 248
Score = 53.1 bits (125), Expect = 3e-06
Identities = 36/156 (23%), Positives = 73/156 (46%), Gaps = 19/156 (12%)
Query: 86 GDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKL 145
GDD G L GE +L++ +++V+++ I+PL L + ++ IQ K L
Sbjct: 1 GDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGR 60
Query: 146 VLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFV 205
LD D + R G D EE+ +A + + ++ + M++ +
Sbjct: 61 RLDFDYKKKR----------------QGKIPD---EELRQALEKFDESKEIAESSMFNLL 101
Query: 206 AKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIK 241
+I+ + L++ Q EYH++++ +LQ V +++
Sbjct: 102 EMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLE 137
>sp|O35180|SH33_RAT SH3-CONTAINING GRB2-LIKE PROTEIN 3 (SH3 DOMAIN PROTEIN 2C) (SH3P13)
gb|AAC14884.1| (AF009604) SH3p13 [Rattus norvegicus]
Length = 291
Score = 52.7 bits (124), Expect = 4e-06
Identities = 39/181 (21%), Positives = 78/181 (42%), Gaps = 23/181 (12%)
Query: 54 LQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFE 113
L+GQ A +++ L L C+++ LG+ + G L GE +A+ +
Sbjct: 21 LRGQVKATGYPQTEGL----LGDCMLKYGRELGEHSAFGNSLVEVGEALKLMAEVKDSLD 76
Query: 114 LQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAG 173
+ V++ I+PL LL + ++ I + L LD D + R + +
Sbjct: 77 INVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKKRVGKIPE------------ 124
Query: 174 AKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLL 233
EE+ +A + E ++ M++F+ +++ + +E +YHR+S +L
Sbjct: 125 -------EEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEIL 177
Query: 234 Q 234
Q
Sbjct: 178 Q 178
>ref|NP_062337.1| SH3-domain GRB2-like B1 (endophilin) [Mus musculus]
gb|AAF73438.1|AF263364_1 (AF263364) endophilin B1a [Mus musculus]
Length = 365
Score = 51.9 bits (122), Expect = 7e-06
Identities = 58/240 (24%), Positives = 102/240 (42%), Gaps = 29/240 (12%)
Query: 6 NRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEAD-- 63
+R Q + +G+AEKTE L L + + E K + K+ LQ A +
Sbjct: 20 SRAVQFTEEKLGQAEKTE-LDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEF 78
Query: 64 ---KRSKKLPLTT-----LAQCLMEGSAILGDDTLLGKMLKLCGETEDKLA---QELIHF 112
K +K P L Q +++ G T G L CGET+ ++ +ELI
Sbjct: 79 VYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQT 138
Query: 113 ELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPA 172
+ + PL E + I K+RK L LD+D+++TR ++ + SSS Q
Sbjct: 139 SAL---NFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETKSSSEQ-- 193
Query: 173 GAKADALREEMEEAANRVEICRDQLSAD-------MYSFVAKEID-YANYFQTLIEVQAE 224
+ + E + A + + +S+ + FV ++ YA +Q ++++Q +
Sbjct: 194 --ELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQ 251
>gb|AAF81225.1|AF257318_1 (AF257318) SH3-containing protein SH3GLB1 [Homo sapiens]
Length = 362
Score = 51.2 bits (120), Expect = 1e-05
Identities = 62/265 (23%), Positives = 112/265 (41%), Gaps = 40/265 (15%)
Query: 6 NRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEAD-- 63
+R Q + +G+AEKTE L L + + E K + K+ LQ A +
Sbjct: 17 SRAVQFTEEKLGQAEKTE-LDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEF 75
Query: 64 ---KRSKKLPLTT-----LAQCLMEGSAILGDDTLLGKMLKLCGETEDKLA---QELIHF 112
K +K P L Q +++ G T G L CGET+ ++ +ELI
Sbjct: 76 VYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQT 135
Query: 113 ELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPA 172
+ + PL E + I K+RK L LD+D+++TR ++ + +SS Q
Sbjct: 136 SAL---NFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQ-- 190
Query: 173 GAKADALREEMEEAANRVEICRDQLSAD-------MYSFVAKEID-YANYFQTLIEVQAE 224
+ + E + A + + +S+ + FV ++ YA +Q ++++Q +
Sbjct: 191 --ELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQ 248
Query: 225 Y-----------HRKSLTLLQAVLP 238
++ S+T + +VLP
Sbjct: 249 LGSFPSNYLSNNNQTSVTPVPSVLP 273
>ref|NP_057093.1| CGI-61 protein [Homo sapiens]
ref|XP_001567.1| CGI-61 protein [Homo sapiens]
gb|AAD34056.1|AF151819_1 (AF151819) CGI-61 protein [Homo sapiens]
dbj|BAA91999.1| (AK001954) unnamed protein product [Homo sapiens]
emb|CAC10395.1| (AL049597) dJ612B15.2.1 (CGI-61 (isoform 1)) [Homo sapiens]
Length = 365
Score = 51.2 bits (120), Expect = 1e-05
Identities = 62/265 (23%), Positives = 112/265 (41%), Gaps = 40/265 (15%)
Query: 6 NRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEAD-- 63
+R Q + +G+AEKTE L L + + E K + K+ LQ A +
Sbjct: 20 SRAVQFTEEKLGQAEKTE-LDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEF 78
Query: 64 ---KRSKKLPLTT-----LAQCLMEGSAILGDDTLLGKMLKLCGETEDKLA---QELIHF 112
K +K P L Q +++ G T G L CGET+ ++ +ELI
Sbjct: 79 VYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQT 138
Query: 113 ELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPA 172
+ + PL E + I K+RK L LD+D+++TR ++ + +SS Q
Sbjct: 139 SAL---NFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSSEQ-- 193
Query: 173 GAKADALREEMEEAANRVEICRDQLSAD-------MYSFVAKEID-YANYFQTLIEVQAE 224
+ + E + A + + +S+ + FV ++ YA +Q ++++Q +
Sbjct: 194 --ELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQ 251
Query: 225 Y-----------HRKSLTLLQAVLP 238
++ S+T + +VLP
Sbjct: 252 LGSFPSNYLSNNNQTSVTPVPSVLP 276
>pir||T16249 hypothetical protein F35A5.8 - Caenorhabditis elegans
gb|AAB52640.1| (U46675) F35A5.8 gene product [Caenorhabditis elegans]
Length = 366
Score = 47.6 bits (111), Expect = 1e-04
Identities = 58/255 (22%), Positives = 108/255 (41%), Gaps = 42/255 (16%)
Query: 5 FNRMRQLANQTVGRAEKTEVLS--EDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEA 62
F+R +QL +T +AE+TE+ S E+LLQ + E H+ ++L + ++G
Sbjct: 16 FSRAKQLTEETFLKAERTELDSHFENLLQRADKTE-----DHT--RRLLSAIEGYLQPNP 68
Query: 63 DKRSKKL----------------PLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLA 106
R +++ L L+ + E G+ T G L +TE++L
Sbjct: 69 TVRMEEVFYEKLELKKDGAIRQNNLEQLSTAMTEAGEQFGETTPYGSALLKVAQTENRLG 128
Query: 107 QELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQ-------- 158
Q Q + + P+ E ++ IQK+RK L LD+D+ ++R ++
Sbjct: 129 QAERELCGQAATNTLLPIRRFLEGDMKTIQKERKVLNSKRLDLDACKSRLKKAKTVDLQT 188
Query: 159 --TSKSSG------LSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEID 210
SK+SG + ++ A A+ D E + ++ + + FV ++
Sbjct: 189 VTNSKTSGGFTIEQAEADVRVAQAEFDKQSEITKLLLEGIQTAHNNQLKCLRDFVEAQMS 248
Query: 211 -YANYFQTLIEVQAE 224
YA Q + ++Q E
Sbjct: 249 FYAQSHQLMADLQRE 263
>pir||T39801 hypothetical sh3-containing protein - fission yeast
(Schizosaccharomyces pombe)
emb|CAB52037.1| (AL109731) hypothetical sh3-containing protein [Schizosaccharomyces
pombe]
Length = 501
Score = 47.3 bits (110), Expect = 2e-04
Identities = 50/246 (20%), Positives = 97/246 (39%), Gaps = 32/246 (13%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
M K F ++ Q + G + LS+D ++ + H+ T ++
Sbjct: 1 MNKHFAKLSQWTGEKFGFDRQKTTLSDDFCSLKGETDAWLVGMDKIHRSCTRWVRNMDKR 60
Query: 61 EA--DKRSKKLPLT-------TLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIH 111
+ D++ K+LP+T L Q L S+ + GK + G +++ L +
Sbjct: 61 KGLLDEKDKQLPVTHVGSSFVELGQALSHSSSNSHTYIMYGKSMVEIGHLQEEFMDYLNN 120
Query: 112 -FELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQ 170
F +E LAE + ++++++ +LV D LS+ +Q
Sbjct: 121 SFLANLENS-------LAEFKALDVKEKKMENRRLVFD---------------ALSTKIQ 158
Query: 171 PAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSL 230
A + L E++ A + E ++ M E D L+++Q +H+KSL
Sbjct: 159 KAKKEESKLEEDLRNARAKYEESLEEFEDRMVQLKELEPDRVENVVRLLQMQIRFHQKSL 218
Query: 231 TLLQAV 236
LL+ +
Sbjct: 219 DLLKGL 224
>ref|NP_064530.1| SH3-containing protein SH3GLB2 [Homo sapiens]
gb|AAF81226.1|AF257319_1 (AF257319) SH3-containing protein SH3GLB2 [Homo sapiens]
Length = 395
Score = 44.5 bits (103), Expect = 0.001
Identities = 62/237 (26%), Positives = 97/237 (40%), Gaps = 32/237 (13%)
Query: 5 FNRMRQLANQTVGRAEKTEVLS--EDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEA 62
F R Q + G+AEKTE+ + E+LL R + K + ++ LQ A
Sbjct: 16 FTRAVQFTEEKFGQAEKTELDAHFENLLA---RADSTKNWTEKILRQTEVLLQPNPSARV 72
Query: 63 D-----KRSKKLPLTT-----LAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHF 112
+ K +K+P LAQ + + ++ LG T GK L E E +L F
Sbjct: 73 EEFLYEKLDRKVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAEAEKQLGAAERDF 132
Query: 113 ELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPA 172
+ PL E + I K+R+ L LD+D+ + R ++ + A
Sbjct: 133 IHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKA----------KAA 182
Query: 173 GAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKS 229
AKA + + +E R I LSA + E+D A Q L Q E+ R++
Sbjct: 183 EAKATTV-PDFQETRPRNYI----LSASASALWNDEVDKAE--QELRVAQTEFDRQA 232
>gb|AAD53328.1|AF078931_1 (AF078931) hydatid disease diagnostic antigen P-29 [Echinococcus
granulosus]
Length = 238
Score = 44.5 bits (103), Expect = 0.001
Identities = 48/213 (22%), Positives = 89/213 (41%), Gaps = 17/213 (7%)
Query: 3 KQFNRMRQLANQTVGRAEKTE--VLSEDLL-QVEKRLELVKQVSHSTHKKLTACLQGQQG 59
K FNR Q A + V + EKT + DL+ ++++ + ++ +T + + + +
Sbjct: 8 KTFNRFTQRAGELVNKNEKTSYPTRTSDLIHEIDQMKAWISKIITATEEFVDINIASKVA 67
Query: 60 AEADKRSKKLPLTTLAQCLMEGSAILGDDTL--LGKMLKLCGETEDKLAQELIHFELQVE 117
K +K+ T +E A + L KML + ++A +F +V
Sbjct: 68 DAFQKNKEKITTTDKLGTALEQVASQSEKAAPQLSKMLTEASDVHQRMATARKNFNSEVN 127
Query: 118 RDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKAD 177
IE L + QK + L ++ LD+DS +T K ++ Q A +A+
Sbjct: 128 TTFIEDLKNFLNTTLSEAQKAKTKLEEVRLDLDSDKT------KLKNAKTAEQKAKWEAE 181
Query: 178 ALREEMEEAANRVEICRDQLSADMYSFVAKEID 210
++E + +RV Q S ++ KE D
Sbjct: 182 VRKDESD--FDRVH----QESLTIFEKTCKEFD 208
>gb|AAF57578.1| (AE003796) CG9834 gene product [Drosophila melanogaster]
Length = 426
Score = 39.9 bits (91), Expect = 0.030
Identities = 54/253 (21%), Positives = 103/253 (40%), Gaps = 18/253 (7%)
Query: 6 NRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVK----QVSHSTHKKLTACLQGQ---- 57
+R+ QL + +G E+TE + +R ++ K ++ T L Q +
Sbjct: 22 SRVVQLTEEKLGTTERTEY-DLHFQNLAERADVTKTWTEKIVRDTESVLIPNPQNRVEDF 80
Query: 58 --QGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQ 115
+ E K + L LA ++E G D G+ L G+ E KL Q F
Sbjct: 81 IFEKIEKSKPKRLSNLEHLALDMIEAGGDFGQDLPYGQALIKVGQAEQKLGQCEHDFIAT 140
Query: 116 VERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSS---LQPA 172
+PL + E+ I K+R L LD+D+ + R ++ G S+ L+ A
Sbjct: 141 SGICFTQPLRKFLDGEMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSAERDLRVA 200
Query: 173 GAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTL 232
A+ D E + + + + +++F+ ++ Y++ +V + R+ L
Sbjct: 201 QAEFDRQAEITKLLLDGISTSQASHLRHLHAFIQTQV---RYYKQCGDVMEQLQRE-LAK 256
Query: 233 LQAVLPQIKAQQE 245
+Q P+++ E
Sbjct: 257 MQHPKPRLRINSE 269
>emb|CAB75944.1| (AJ245428) type I keratin Y1 [Branchiostoma lanceolatum]
Length = 406
Score = 39.9 bits (91), Expect = 0.030
Identities = 43/170 (25%), Positives = 78/170 (45%), Gaps = 24/170 (14%)
Query: 79 MEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFL--LAEVEIPNIQ 136
+E A+L D+ L + +++LA E + E Q+E E F+ + + E+ ++
Sbjct: 182 IEKRAVLEDE------LNMLKREQEELAMEKVDLEGQIEGAQGELDFIKQIHKQEVAELK 235
Query: 137 KQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQ 196
++ K + ++ +R + ++ L A+RE+ EE A R ++
Sbjct: 236 ERIKASGNIEIE-----SRMETVDLNAALK-----------AIREQYEEIARRNRADVEK 279
Query: 197 LSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEA 246
D S V E +N TL++ + R++LT LQA L +KAQQ A
Sbjct: 280 SFQDEVSAVKVEQAQSNEALTLVKSEINEIRRTLTGLQAELEALKAQQAA 329
>gb|AAF07196.1|AF194970_1 (AF194970) LEK1 [Mus musculus]
Length = 2473
Score = 39.9 bits (91), Expect = 0.030
Identities = 51/202 (25%), Positives = 85/202 (41%), Gaps = 23/202 (11%)
Query: 2 KKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQG-- 59
KK+ N + L+ + + E+ +E L +V + LE K H+K+T+C+ Q+
Sbjct: 437 KKEMNSIISLSKKNI---EELTQANEALKEVNEALEQEKMNLLQKHEKITSCIAEQERSI 493
Query: 60 AEADKRSKKLPLTTLAQCLMEGSAILGD-----------DTLLGKMLKLCGETEDKLAQE 108
AE + K+ L L +C E A+L D + L ML C + E
Sbjct: 494 AELSDQYKQERLQLLQRC-EETEAVLEDLRGNYKTAQENNAKLECMLSECTALCENRKNE 552
Query: 109 LIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSS 168
L + ++ E L LA E ++ RK + +L ++ + R+ T+K S S+
Sbjct: 553 LEQLKETFAKEQQEFLTKLAFAE----EQNRKLMLELEIEQQTVRSEITNTNKHS--MSA 606
Query: 169 LQPAGAKADALREEMEEAANRV 190
+ L EE E N V
Sbjct: 607 TDGLRQECLTLNEEQNEQQNEV 628
>ref|NP_056972.1| hook1 protein [Homo sapiens]
ref|XP_002018.1| hook1 protein [Homo sapiens]
gb|AAC09298.1| (AF044923) hook1 protein [Homo sapiens]
Length = 728
Score = 39.9 bits (91), Expect = 0.030
Identities = 45/192 (23%), Positives = 79/192 (40%), Gaps = 32/192 (16%)
Query: 34 KRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGK 93
+R+E +++ H+K+ Q+ ++ R + + L + L E +
Sbjct: 487 ERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGS---------- 536
Query: 94 MLKLCGETEDKLAQEL---------IHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAK 144
K GE+ KL Q+L +H ELQ ++++IE L + I + L K
Sbjct: 537 --KSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQK 594
Query: 145 LVLDMDSSRTRWQQTSKSSG-----LSSSLQPAGAKADALREEMEEAANRVEICRDQLSA 199
DM + R++ + + L L PA A+ LR+++ E R+EI +
Sbjct: 595 KDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECK- 653
Query: 200 DMYSFVAKEIDY 211
VAK DY
Sbjct: 654 -----VAKFRDY 660
>ref|NP_071330.1| differentially expressed in FDCP (mouse homolog) 6 [Homo sapiens]
emb|CAC08450.1| (AJ276095) Def-6 protein [Homo sapiens]
Length = 631
Score = 39.5 bits (90), Expect = 0.039
Identities = 46/204 (22%), Positives = 95/204 (46%), Gaps = 22/204 (10%)
Query: 2 KKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAE 61
+++ R++QL + + ++ E+L E Q E+ L+ ++ S H++L L+GQ E
Sbjct: 344 EEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQL-RE 402
Query: 62 ADKRSKKLPLTTLAQCLMEGSAILGDDTLL--GKMLKLCGETEDKLAQELIHFELQVERD 119
A++ A+ M+ L ++ + +K E + +L QE + E++ RD
Sbjct: 403 AEQ----------ARASMQAEMELKEEEAARQRQRIKELEEMQQRL-QEALQLEVKARRD 451
Query: 120 VIEPLFLLAEVEIPNIQKQR-KHLAKLVLDMDSSRTRWQQTSKS-----SGLSSSLQPAG 173
E +A+ + ++++ K L +L + + R QQ + + S SLQ A
Sbjct: 452 --EESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQ 509
Query: 174 AKADALREEMEEAANRVEICRDQL 197
+ + +R+ + A VE + +L
Sbjct: 510 QQLEEVRQNRQRADEDVEAAQRKL 533
>emb|CAB65622.1| (Z97832) dJ329A5.3 (KIAA06460 protein) [Homo sapiens]
Length = 694
Score = 39.5 bits (90), Expect = 0.039
Identities = 46/204 (22%), Positives = 95/204 (46%), Gaps = 22/204 (10%)
Query: 2 KKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAE 61
+++ R++QL + + ++ E+L E Q E+ L+ ++ S H++L L+GQ E
Sbjct: 407 EEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQL-RE 465
Query: 62 ADKRSKKLPLTTLAQCLMEGSAILGDDTLL--GKMLKLCGETEDKLAQELIHFELQVERD 119
A++ A+ M+ L ++ + +K E + +L QE + E++ RD
Sbjct: 466 AEQ----------ARASMQAEMELKEEEAARQRQRIKELEEMQQRL-QEALQLEVKARRD 514
Query: 120 VIEPLFLLAEVEIPNIQKQR-KHLAKLVLDMDSSRTRWQQTSKS-----SGLSSSLQPAG 173
E +A+ + ++++ K L +L + + R QQ + + S SLQ A
Sbjct: 515 --EESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQ 572
Query: 174 AKADALREEMEEAANRVEICRDQL 197
+ + +R+ + A VE + +L
Sbjct: 573 QQLEEVRQNRQRADEDVEAAQRKL 596
>gb|AAF61445.1|AF139055_1 (AF139055) nonmuscle myosin heavy chain-B [Rattus norvegicus]
Length = 1976
Score = 39.1 bits (89), Expect = 0.051
Identities = 55/250 (22%), Positives = 104/250 (41%), Gaps = 33/250 (13%)
Query: 6 NRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKR 65
+R+RQL + E+ E E +EK++ ++ T KK+ L +G E K+
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIEGLEEAKK 1395
Query: 66 SKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQEL--IHFELQVERDVIEP 123
+ L+Q L E +L D L +T+++L QEL + +L +R ++
Sbjct: 1396 KLLKDVEALSQRLEE--KVLAYDKL--------EKTKNRLQQELDDLTVDLDHQRQIVS- 1444
Query: 124 LFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRW-QQTSKSSGLSSSLQPAGAKADALREE 182
N++K++K +L+ + R+ ++ ++ + + EE
Sbjct: 1445 ----------NLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKALSLARALEE 1494
Query: 183 MEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTL------IEVQAEYHRKSLTLLQAV 236
EA E QL ADM ++ + D L +E Q E R T L+ +
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR---TQLEEL 1551
Query: 237 LPQIKAQQEA 246
+++A ++A
Sbjct: 1552 EDELQATEDA 1561
>dbj|BAA36494.1| (AB022023) nonmuscle myosin heavy chain B [Bos taurus]
Length = 1976
Score = 38.7 bits (88), Expect = 0.067
Identities = 54/248 (21%), Positives = 101/248 (39%), Gaps = 29/248 (11%)
Query: 6 NRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKR 65
+R+RQL + E+ E E +EK+L+ ++ T KK+ L + E K+
Sbjct: 1336 SRIRQLEEERSSLQEQQEEEEEARRSLEKQLQALQAQLTDTKKKVDDDLGTIENLEEAKK 1395
Query: 66 SKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLF 125
+ L+Q L E + L D L +L E +D L +L +R ++
Sbjct: 1396 KLLKDVEVLSQRLEEKA--LAYDKLEKTKTRLQQELDDLLV------DLDHQRQIVS--- 1444
Query: 126 LLAEVEIPNIQKQRKHLAKLVLDMDSSRTRW-QQTSKSSGLSSSLQPAGAKADALREEME 184
N++K++K +L+ + + R+ ++ ++ + + EE
Sbjct: 1445 --------NLEKKQKKFDQLLAEEKNISARYAEERDRAEAEAREKETKALSLARALEEAL 1496
Query: 185 EAANRVEICRDQLSADMYSFVAKEIDYANYFQTL------IEVQAEYHRKSLTLLQAVLP 238
EA E QL ADM ++ + D L +E Q E R T L+ +
Sbjct: 1497 EAREEAERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR---TQLEELED 1553
Query: 239 QIKAQQEA 246
+++A ++A
Sbjct: 1554 ELQATEDA 1561
>pir||S58922 tropomyosin isoform TMII - Caenorhabditis elegans
dbj|BAA07541.1| (D38539) CeTMII [Caenorhabditis elegans]
dbj|BAA07544.1| (D38541) CeTMII [Caenorhabditis elegans]
Length = 284
Score = 38.7 bits (88), Expect = 0.067
Identities = 63/278 (22%), Positives = 116/278 (41%), Gaps = 43/278 (15%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
+KK+ M+ + + RA+ E E + Q+ ++LE V++ T KK+T Q G
Sbjct: 4 IKKKMQAMKIEKDNALDRADAAE---EKVRQITEKLERVEEELRDTQKKMT-----QTGD 55
Query: 61 EADKRSKKLPLT---------TLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIH 111
+ DK + L T+ + E +++ TLL + L+ E K+A E +
Sbjct: 56 DLDKAQEDLSAATSKLEEKEKTVQEAEAEVASLNRRMTLLEEELER-AEERLKIATEKLE 114
Query: 112 ------FELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGL 165
E + R V+E L E ++ Q K L + D R + K + +
Sbjct: 115 EATHNVDESERVRKVMENRSLQDEERANTVEAQLKEAQLLAEEAD--RKYDEVARKLAMV 172
Query: 166 SSSLQPAGAKADA-------LREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTL 218
+ L+ A +A+A L EE+ N ++ L + +E Y +T+
Sbjct: 173 EADLERAEERAEAGENKIVELEEELRVVGNNLK----SLEVSEEKALQREDSYEEQIRTV 228
Query: 219 ------IEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEK 250
E +AE+ +S+ LQ + +++ ++A V K
Sbjct: 229 SSRLKEAETRAEFAERSVQKLQKEVDRLEELRDAEVLK 266
>sp|Q07068|TPM1_CIOIN TROPOMYOSIN, SMOOTH MUSCLE/FIBROBLAST CTM1
pir||A45488 body-wall muscle tropomyosin - sea squirt (Ciona intestinalis)
emb|CAA45469.1| (X64105) tropomyosin [Ciona intestinalis]
Length = 284
Score = 38.7 bits (88), Expect = 0.067
Identities = 62/270 (22%), Positives = 115/270 (41%), Gaps = 45/270 (16%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEV-----------LSEDLLQVEKRLELVKQVSHSTHKK 49
+KK+ ++ + RAE+ E L E+L ++KRL+ + ++ +K
Sbjct: 4 IKKKMTMLKLDKENAIDRAEQAETDKKSAEDKATGLEEELQGLQKRLKATEDELDTSQEK 63
Query: 50 LTACLQGQQGAEADKRSKKLPLTTLAQ--CLMEGSAILGDDTLLGKMLKLCGETEDKLAQ 107
L ++ + AE + + +L + L+E + L + KL E +K A
Sbjct: 64 LRTAIENLENAEKKAADAEQEVASLNRRITLVEEELDRAQERLTISLSKL--EEAEKAAD 121
Query: 108 ELIHFELQVERDVIEPLFLLAE--VEIPNIQ-KQRKHLAKLVLDMDSSRTRWQQTSKSSG 164
E + R VIE L E +E+ IQ + K++A+ D+ R + K
Sbjct: 122 -----ESERGRKVIENRSLKDEERLEVQEIQLTEAKNIAE-----DADRKYVEVARKLVM 171
Query: 165 LSSSLQP-------AGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQT 217
+ + L+ A +KA L EE++ AN ++ L A + AKE + +T
Sbjct: 172 VEAELERGEERAELAESKAIELEEELKIVANNLK----SLEASAEKYAAKEGIFEEEIKT 227
Query: 218 L------IEVQAEYHRKSLTLLQAVLPQIK 241
L E +AE+ KS+ L+ + +++
Sbjct: 228 LSDKLKDSETRAEFAEKSVVKLEKNIDELE 257
>ref|NP_064322.1| sperm tail associated protein [Mus musculus]
dbj|BAA82514.1| (AB029919) sperm tail associated protein [Mus musculus]
Length = 1022
Score = 38.3 bits (87), Expect = 0.088
Identities = 52/233 (22%), Positives = 92/233 (39%), Gaps = 26/233 (11%)
Query: 29 LLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDD 88
L EK L+++ KK+ Q +E +R + L + L+E +L +
Sbjct: 576 LSNAEKEKSLLQKTLDEDEKKIDELFHSTQVSEQKQRELTNSIRKLEEELLEIKGLLEEK 635
Query: 89 TLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLD 148
+ LK E E L +E+ + +R + ++HL KL D
Sbjct: 636 R---EQLKKSKEQEKALEEEIEALRQEAKRKE---------------KMAKEHLRKL--D 675
Query: 149 MDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKE 208
+ + + TS+SS L SSL + ++E E A + + L + S + KE
Sbjct: 676 EEKENLQAELTSRSSHLDSSLNKYNSSQKVIQELNAEIARQKDSIM-ILQTQLDSAIQKE 734
Query: 209 IDYANYFQTLIEVQA--EYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEE 259
N FQ ++ +A E RKS + ++ +A E S + L++
Sbjct: 735 ---KNCFQNMVSKEAYEELVRKSGNCQDDLTQALEKLTQATSETKSLNRSLQQ 784
>sp|P50478|AMPH_CHICK AMPHIPHYSIN
pir||S22700 amphiphysin - chicken
emb|CAA42953.1| (X60422) Amphiphysin [Gallus gallus]
Length = 682
Score = 38.3 bits (87), Expect = 0.088
Identities = 49/233 (21%), Positives = 104/233 (44%), Gaps = 31/233 (13%)
Query: 1 MKKQFNRMRQLANQTVGRAEKT-EVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQG 59
++K+ NR ++ Q +G+A++T + E+ +Q KR E + A ++G Q
Sbjct: 13 VQKRLNRAQEKVLQKLGKADETKDEQFEEYVQNFKRQEAEGSRLQRELRAYLAAIKGMQD 72
Query: 60 AEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERD 119
A SKK L + L E + D + +K+ GE D+L ++ +
Sbjct: 73 A-----SKK-----LTESLHE---VYEPDWYGREDVKMIGEKCDELWEDF-------HQK 112
Query: 120 VIEPLFLLAEV---EIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKA 176
+++ L + + P+I+ + ++ ++D DS+R + L SS + +
Sbjct: 113 LVDGSLLTLDTYLGQFPDIKTRIAKRSRKLVDYDSARHHLE------ALQSSKRKDEGRI 166
Query: 177 DALREEMEEAANRVEICRDQLSADMYSFVAKEID-YANYFQTLIEVQAEYHRK 228
EE ++A E L ++ S ++ + Y N F+ + ++A++H++
Sbjct: 167 TKAEEEFQKAQKVFEEFNTDLQEELPSLWSRRVGFYVNTFKNVSSLEAKFHKE 219
>pir||T13030 microtubule binding protein D-CLIP-190 - fruit fly (Drosophila
melanogaster)
gb|AAB96783.1| (AF041382) microtubule binding protein D-CLIP-190 [Drosophila
melanogaster]
Length = 1690
Score = 37.9 bits (86), Expect = 0.11
Identities = 54/262 (20%), Positives = 110/262 (41%), Gaps = 24/262 (9%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTE-VLSEDLLQ---VEKRLELVKQVSHSTHKKLTACLQG 56
++KQ + ++QLA Q EKTE +++ L+ +E++L L + KK +
Sbjct: 697 LEKQISDLKQLAEQEKLVREKTENAINQIQLEKESIEQQLALKQNELEDFQKKQSESEVH 756
Query: 57 QQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIH----- 111
Q +A K L L + L + L + TL + L+ E K + +I
Sbjct: 757 LQEIKAQNTQKDLELVESGESLKKLQQQLEEKTLGHEKLQAALEELKKEKETIIKEKEQE 816
Query: 112 -FELQVERDVIEPLFLLAEVEIPNIQKQ--------RKHLAKLVLDMDSSRTRWQQT-SK 161
+LQ + E + +V++ +Q+Q K +AKL ++ +++ ++T S+
Sbjct: 817 LQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTVAKLHDEISQLKSQAEETQSE 876
Query: 162 SSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEV 221
S+L+ + +A +EE A + ++Q++ + E++ +
Sbjct: 877 LKSTESNLEAKSKQLEAANGSLEEEAKKSGQLQEQITK-----LKSEVEETQAALSSYHT 931
Query: 222 QAEYHRKSLTLLQAVLPQIKAQ 243
E K L A L ++ +
Sbjct: 932 DVESKTKQLEAANAALEKVNKE 953
>emb|CAC10340.1| (AL139421) dJ717I23.1 (novel protein similar to Xenopus laevis Sojo
protein) [Homo sapiens]
Length = 656
Score = 36.7 bits (83), Expect = 0.26
Identities = 46/250 (18%), Positives = 107/250 (42%), Gaps = 15/250 (6%)
Query: 2 KKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQ---VSHSTHKKLTACLQGQQ 58
K+ + R N+ + ++ +L + ++EK+ VK+ + HST +LT LQ ++
Sbjct: 161 KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKRE 220
Query: 59 GAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVER 118
E + ++ L + + L E +L L L+ T L EL ++++E
Sbjct: 221 VLETELQNAHGELKSTLRQLQELRDVLQKAQL---SLEEKYTTIKDLTAELRECKMEIED 277
Query: 119 DVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADA 178
E L + ++ N + +++ LDM R + K L +L+ + +
Sbjct: 278 KKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKE 337
Query: 179 LREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLP 238
+++E ++++ ++QL + + E Q + +++ E R + + +
Sbjct: 338 CNKQIESLNDKLQNAKEQLREKEFIMLQNE-------QEISQLKKEIERTQQRMKE--ME 388
Query: 239 QIKAQQEAWV 248
+ +QE ++
Sbjct: 389 SVMKEQEQYI 398
>emb|CAB58234.1| (AJ250201) lamin B1 protein [Danio rerio]
Length = 588
Score = 36.7 bits (83), Expect = 0.26
Identities = 49/234 (20%), Positives = 96/234 (40%), Gaps = 12/234 (5%)
Query: 28 DLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGD 87
DL + RL+ V+ + ++ L + ++ E ++ + L L+ L D
Sbjct: 128 DLTSSQNRLKDVEALLNAKEAALNTAVSERKTLENTLSDLQIRVQELEGGLISAKKQLSD 187
Query: 88 DTLLGKMLK-LCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLV 146
+TLL L+ C ++L FE +++ L EV+ + LA+ +
Sbjct: 188 ETLLRVDLENRCQSLMEELEFRKNMFEEEIKDTRRRHETRLVEVDSGRQMEYEFKLAQAL 247
Query: 147 LDMDSS--------RTRWQQT--SKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQ 196
DM + +QT SK + S + + A REE+ E+ RVE Q
Sbjct: 248 TDMRQQHDEQVKLYKEEMEQTYVSKLENIRLSSEMNSSSASMAREELRESTLRVESLAGQ 307
Query: 197 LSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEK 250
L A++ D N + + + + R+SL + + +I+A+ + +++
Sbjct: 308 L-ANLQKEARAWQDRINELEGALSHEKDLSRRSLAEKEREIAEIRAKMQQQLDE 360
Database: nr
Number of letters in database: 188,047,558
Number of sequences in database: 594,795
Lambda K H
0.314 0.129 0.350
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83480675
Number of Sequences: 594795
Number of extensions: 3040526
Number of successful extensions: 10356
Number of sequences better than 10.0: 156
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 10241
Number of HSP's gapped (non-prelim): 206
length of query: 260
length of database: 188,047,558
effective HSP length: 63
effective length of query: 197
effective length of database: 150,575,473
effective search space: 29663368181
effective search space used: 29663368181
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 70 (31.7 bits)