Score E
Sequences producing significant alignments: (bits) Value
ref|NP_005931.1| matrix metalloproteinase 11 (stromelysin 3... 902 0.0
ref|XP_000855.1| similar to matrix metalloproteinase 11 (st... 901 0.0
sp|P24347|COGY_HUMAN STROMELYSIN-3 PRECURSOR (MATRIX METALL... 899 0.0
ref|XP_000857.1| similar to matrix metalloproteinase 11 (st... 848 0.0
ref|NP_032632.1| matrix metalloproteinase 11; stromelysin 3... 780 0.0
pir||A44399 stromelysin 3 (EC 3.4.24.-) - mouse 777 0.0
pir||JC6197 stromelysin 3 (EC 3.4.24.-) - rat 773 0.0
ref|NP_037112.1| matrix metalloproteinase 11 (stromelysin 3... 773 0.0
sp|Q11005|COGY_XENLA STROMELYSIN-3 PRECURSOR (MATRIX METALL... 603 e-171
dbj|BAA82966.1| (AB021226) membrane-type-5 matrix metallopr... 311 1e-83
ref|NP_006681.1| matrix metalloproteinase 24 (membrane-inse... 309 4e-83
ref|NP_034938.1| matrix metalloproteinase 24; Membrane type... 304 1e-81
gb|AAB51753.1| (U54984) membrane-type matrix metalloprotein... 295 8e-79
ref|NP_004986.1| matrix metalloproteinase 14 (membrane-inse... 294 1e-78
pir||I38046 MT-MMP - human >gi|804994|emb|CAA58519.1| (X835... 294 1e-78
sp|P50281|COGT_HUMAN MATRIX METALLOPROTEINASE-14 PRECURSOR ... 294 1e-78
gb|AAB86602.1| (AF022432) matrix metalloproteinase-14 [Mus ... 294 1e-78
emb|CAA62432.1| (X90925) MT-MMP protein [Homo sapiens] 294 1e-78
gb|AAD13803.1| (U73940) membane-type 1 metalloproteinase pr... 293 2e-78
emb|CAA62897.1| (X91785) membrane-type metalloproteinase [R... 293 2e-78
ref|NP_062698.1| membrane-type-3 matrix metalloproteinase [... 293 3e-78
gb|AAD38324.1|AF067419_1 (AF067419) membrane-type 1 matrix ... 293 4e-78
sp|Q95220|COGT_RABIT MATRIX METALLOPROTEINASE-14 PRECURSOR ... 293 4e-78
gb|AAG17704.1|AF282844_1 (AF282844) matrix metalloproteinas... 292 5e-78
gb|AAF66697.2|AF145442_1 (AF145442) leukolysin [Homo sapien... 292 5e-78
sp|O35548|COGV_RAT MATRIX METALLOPROTEINASE-16 PRECURSOR (M... 292 5e-78
dbj|BAA22223.1| (D63886) MT3-MMP-del [Rattus sp.] 292 5e-78
sp|P51512|COGV_HUMAN MATRIX METALLOPROTEINASE-16 PRECURSOR ... 292 7e-78
sp|Q10739|COGT_RAT MATRIX METALLOPROTEINASE-14 PRECURSOR (M... 291 1e-77
gb|AAG28170.1|AF290429_1 (AF290429) membrane-type matrix me... 291 2e-77
dbj|BAA36551.1| (AB010921) Membrane-type matrix metalloprot... 290 2e-77
ref|NP_005932.1| matrix metalloproteinase 16 (membrane-inse... 290 2e-77
emb|CAB92315.1| (AJ010731) membrane-type-4 matrix metallopr... 286 3e-76
ref|NP_035976.1| matrix metalloproteinase 17; membrane type... 286 4e-76
ref|NP_032634.1| matrix metalloproteinase 14 (membrane-inse... 284 2e-75
dbj|BAA13071.1| (D86331) matrix metalloproteinase, MT2MMP [... 284 2e-75
ref|NP_002419.1| matrix metalloproteinase 15 (membrane-inse... 284 2e-75
sp|P53690|COGT_MOUSE MATRIX METALLOPROTEINASE-14 PRECURSOR ... 281 1e-74
gb|AAF61270.1|AF244994_1 (AF244994) membrane type-3 matrix ... 279 7e-74
ref|NP_004132.1| matrix metalloproteinase 17 (membrane-inse... 277 2e-73
gb|AAF47255.1| (AE003464) CG4859 gene product [Drosophila m... 273 3e-72
ref|NP_032635.1| matrix metalloproteinase 15; Membrane type... 273 3e-72
gb|AAB07491.1| (U66463) membrane type-matrix metalloprotein... 268 8e-71
dbj|BAA22225.1| (D85510) SMCP-2 [Homo sapiens] 259 4e-68
ref|NP_057239.1| matrix metalloproteinase 17 (membrane-inse... 254 2e-66
sp|Q28397|COG3_HORSE STROMELYSIN-1 PRECURSOR (MATRIX METALL... 254 2e-66
sp|P28862|COG3_MOUSE STROMELYSIN-1 PRECURSOR (MATRIX METALL... 253 4e-66
ref|NP_034939.1| matrix metalloproteinase 3; progelatinase;... 253 4e-66
gb|AAA36321.1| (J03209) matrix metalloproteinase-3 [Homo sa... 252 6e-66
ref|NP_002413.1| matrix metalloproteinase 3 (stromelysin 1,... 252 6e-66
>ref|NP_005931.1| matrix metalloproteinase 11 (stromelysin 3) [Homo sapiens]
emb|CAA40918.1| (X57766) stromelysin-3 precursor [Homo sapiens]
Length = 488
Score = 902 bits (2306), Expect = 0.0
Identities = 422/452 (93%), Positives = 422/452 (93%)
Query: 37 DVHHLHAERRGPQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCGVPDPSDGLSARNRQK 96
DVHHLHAERRGPQ CGVPDPSDGLSARNRQK
Sbjct: 37 DVHHLHAERRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQK 96
Query: 97 RFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIM 156
RFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIM
Sbjct: 97 RFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIM 156
Query: 157 IDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHE 216
IDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHE
Sbjct: 157 IDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHE 216
Query: 217 FGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAG 276
FGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAG
Sbjct: 217 FGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAG 276
Query: 277 IDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHW 336
IDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHW
Sbjct: 277 IDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHW 336
Query: 337 QGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPE 396
QGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPE
Sbjct: 337 QGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPE 396
Query: 397 KNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYW 456
KNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYW
Sbjct: 397 KNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYW 456
Query: 457 KFDPVKVKALEGFPRLVGPDFFGCAEPANTFL 488
KFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
Sbjct: 457 KFDPVKVKALEGFPRLVGPDFFGCAEPANTFL 488
>ref|XP_000855.1| similar to matrix metalloproteinase 11 (stromelysin 3) (H. sapiens)
[Homo sapiens]
Length = 488
Score = 901 bits (2302), Expect = 0.0
Identities = 421/452 (93%), Positives = 421/452 (93%)
Query: 37 DVHHLHAERRGPQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCGVPDPSDGLSARNRQK 96
D HHLHAERRGPQ CGVPDPSDGLSARNRQK
Sbjct: 37 DAHHLHAERRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQK 96
Query: 97 RFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIM 156
RFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIM
Sbjct: 97 RFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIM 156
Query: 157 IDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHE 216
IDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHE
Sbjct: 157 IDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHE 216
Query: 217 FGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAG 276
FGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAG
Sbjct: 217 FGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAG 276
Query: 277 IDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHW 336
IDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHW
Sbjct: 277 IDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHW 336
Query: 337 QGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPE 396
QGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPE
Sbjct: 337 QGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPE 396
Query: 397 KNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYW 456
KNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYW
Sbjct: 397 KNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYW 456
Query: 457 KFDPVKVKALEGFPRLVGPDFFGCAEPANTFL 488
KFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
Sbjct: 457 KFDPVKVKALEGFPRLVGPDFFGCAEPANTFL 488
>sp|P24347|COGY_HUMAN STROMELYSIN-3 PRECURSOR (MATRIX METALLOPROTEINASE-11) (MMP-11)
(ST3) (SL-3)
pir||S13423 stromelysin 3 (EC 3.4.24.-) precursor - human
prf||1703414A metalloprotease [Homo sapiens]
Length = 488
Score = 899 bits (2297), Expect = 0.0
Identities = 421/452 (93%), Positives = 421/452 (93%)
Query: 37 DVHHLHAERRGPQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCGVPDPSDGLSARNRQK 96
DVHHLHAERRGPQ CGVPDPSDGLSARNRQK
Sbjct: 37 DVHHLHAERRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQK 96
Query: 97 RFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIM 156
RFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIM
Sbjct: 97 RFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIM 156
Query: 157 IDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHE 216
IDFARYW GDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHE
Sbjct: 157 IDFARYWDGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHE 216
Query: 217 FGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAG 276
FGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAG
Sbjct: 217 FGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAG 276
Query: 277 IDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHW 336
IDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHW
Sbjct: 277 IDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHW 336
Query: 337 QGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPE 396
QGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPE
Sbjct: 337 QGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPE 396
Query: 397 KNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYW 456
KNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYW
Sbjct: 397 KNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYW 456
Query: 457 KFDPVKVKALEGFPRLVGPDFFGCAEPANTFL 488
KFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
Sbjct: 457 KFDPVKVKALEGFPRLVGPDFFGCAEPANTFL 488
>ref|XP_000857.1| similar to matrix metalloproteinase 11 (stromelysin 3) (H. sapiens)
[Homo sapiens]
Length = 922
Score = 848 bits (2168), Expect = 0.0
Identities = 393/393 (100%), Positives = 393/393 (100%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD
Sbjct: 50 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 109
Query: 140 VTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 199
VTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETW
Sbjct: 110 VTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 169
Query: 200 TIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQ 259
TIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQ
Sbjct: 170 TIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQ 229
Query: 260 PWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRL 319
PWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRL
Sbjct: 230 PWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRL 289
Query: 320 RGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTE 379
RGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTE
Sbjct: 290 RGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTE 349
Query: 380 LGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAA 439
LGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAA
Sbjct: 350 LGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAA 409
Query: 440 FQDADGYAYFLRGRLYWKFDPVKVKALEGFPRL 472
FQDADGYAYFLRGRLYWKFDPVKVKALEGFPRL
Sbjct: 410 FQDADGYAYFLRGRLYWKFDPVKVKALEGFPRL 442
>ref|NP_032632.1| matrix metalloproteinase 11; stromelysin 3 [Mus musculus]
sp|Q02853|COGY_MOUSE STROMELYSIN-3 PRECURSOR (MATRIX METALLOPROTEINASE-11) (MMP-11)
(ST3) (SL-3)
emb|CAA78248.1| (Z12604) stromelysin-3 [Mus musculus]
Length = 492
Score = 780 bits (1993), Expect = 0.0
Identities = 365/449 (81%), Positives = 385/449 (85%)
Query: 39 HHLHAERRGPQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCGVPDPSDGLSARNRQKRF 98
H H ++GP+ CGVPD D L+ARNRQKRF
Sbjct: 43 HRHHPVKKGPRLLHAALPNTLTSVPASHWVPSPAGSSRPLRCGVPDLPDVLNARNRQKRF 102
Query: 99 VLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMID 158
VLSGGRWEKTDLTYRILRFPWQLV+EQVRQT+AEAL+VWS+VTPLTFTEVHEGRADIMID
Sbjct: 103 VLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMID 162
Query: 159 FARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFG 218
FARYWHGD+LPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGD+QGTDLLQVAAHEFG
Sbjct: 163 FARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFG 222
Query: 219 HVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGID 278
HVLGLQHTTAAKALMS FYTFRYPLSLSPDD RG+QHLYG+P TS P L QAG D
Sbjct: 223 HVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQMAPTSPAPTLSSQAGTD 282
Query: 279 TNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQG 338
TNEIA LEP+ PPD CE SFDAVSTIRGELFFFKAGFVWRLR G+LQPGYPALASRHWQG
Sbjct: 283 TNEIALLEPETPPDVCETSFDAVSTIRGELFFFKAGFVWRLRSGRLQPGYPALASRHWQG 342
Query: 339 LPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKN 398
LPSPVDAAFEDAQG IWFFQGAQYWVYDGEKPVLGPAPL++LGL PVHAALVWGPEKN
Sbjct: 343 LPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSKLGLQGSPVHAALVWGPEKN 402
Query: 399 KIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKF 458
KIYFFRG DYWRFHP T+RVD+PVPRR+TDWRGVPSEIDAAFQDA+GYAYFLRG LYWKF
Sbjct: 403 KIYFFRGGDYWRFHPRTQRVDNPVPRRSTDWRGVPSEIDAAFQDAEGYAYFLRGHLYWKF 462
Query: 459 DPVKVKALEGFPRLVGPDFFGCAEPANTF 487
DPVKVK LEGFPR VGPDFF CAEPANTF
Sbjct: 463 DPVKVKVLEGFPRPVGPDFFDCAEPANTF 491
>pir||A44399 stromelysin 3 (EC 3.4.24.-) - mouse
Length = 492
Score = 777 bits (1985), Expect = 0.0
Identities = 364/449 (81%), Positives = 384/449 (85%)
Query: 39 HHLHAERRGPQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCGVPDPSDGLSARNRQKRF 98
H H ++GP+ CGVPD D L+ARNRQKRF
Sbjct: 43 HRHHPVKKGPRLLHAALPNTLTSVPASHWVPSPAGSSRPLRCGVPDLPDVLNARNRQKRF 102
Query: 99 VLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMID 158
VLSGGRWEKTDLTYRILRFPWQLV+EQVRQT+AEAL+VWS+VTPLTFTEVHEGRADIMID
Sbjct: 103 VLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMID 162
Query: 159 FARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFG 218
FARYW GD+LPFDGPGGILAH FFPKTHREGDVHFDYDETWTIGD+QGTDLLQVAAHEFG
Sbjct: 163 FARYWDGDNLPFDGPGGILAHGFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFG 222
Query: 219 HVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGID 278
HVLGLQHTTAAKALMS FYTFRYPLSLSPDD RG+QHLYG+P T TS P L QAG D
Sbjct: 223 HVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQMTPTSPAPTLSSQAGTD 282
Query: 279 TNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQG 338
TNEIA LEP+ PPD CE SFDAVSTIRGELFFFKAGFVWRLR G+LQPGYPALASRHWQG
Sbjct: 283 TNEIALLEPETPPDVCETSFDAVSTIRGELFFFKAGFVWRLRSGRLQPGYPALASRHWQG 342
Query: 339 LPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKN 398
LPSPVDAAFEDAQG IWFFQGAQYWVYDGEKPVLGPAPL++LGL PVHAALVWGPEKN
Sbjct: 343 LPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSKLGLQGSPVHAALVWGPEKN 402
Query: 399 KIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKF 458
KIYFFRG DYWRFHP T+RVD+PVPRR+TDWRGVPSEIDAAFQDA+GYAYFLRG LYWKF
Sbjct: 403 KIYFFRGGDYWRFHPRTQRVDNPVPRRSTDWRGVPSEIDAAFQDAEGYAYFLRGHLYWKF 462
Query: 459 DPVKVKALEGFPRLVGPDFFGCAEPANTF 487
DPVKVK LEGFPR VGPDFF CAEPANTF
Sbjct: 463 DPVKVKVLEGFPRPVGPDFFDCAEPANTF 491
>pir||JC6197 stromelysin 3 (EC 3.4.24.-) - rat
Length = 491
Score = 773 bits (1975), Expect = 0.0
Identities = 359/408 (87%), Positives = 376/408 (91%), Gaps = 1/408 (0%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGVPDP D L+ARNRQKRFVLSGGRWEKTDLTYRILRFPWQLV+EQVRQT+AEAL+VWS+
Sbjct: 84 CGVPDPPDVLNARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALRVWSE 143
Query: 140 VTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 199
VTPLTFTEVHEGRADIMIDF RYWHGD+LPFDGPGGILAHAFFPKTHREGDVHFDYDETW
Sbjct: 144 VTPLTFTEVHEGRADIMIDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 203
Query: 200 TIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQ 259
TIGD +GTDLLQVAAHEFGHVLGLQHTTAAKALMS FYTFRYPLSLSPDD RG+QHLYG+
Sbjct: 204 TIGD-KGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGR 262
Query: 260 PWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRL 319
P T TS TP L QAG DTNEIA EP+ PP+ CE SFDAVSTIRGELFFFKAGFVWRL
Sbjct: 263 PQLTPTSPTPTLSSQAGTDTNEIALQEPEVPPEVCETSFDAVSTIRGELFFFKAGFVWRL 322
Query: 320 RGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTE 379
R GQLQPGYPALASRHWQGLPSPVDAAFEDAQG IWFFQGAQYWVYDGEKPVLGPAPL++
Sbjct: 323 RSGQLQPGYPALASRHWQGLPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSK 382
Query: 380 LGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAA 439
LGL PVHAALVWGPEKNKIYFFRG DYWRFHP T+RVD+PVPRR TDWRGVPSEIDAA
Sbjct: 383 LGLQGSPVHAALVWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRTTDWRGVPSEIDAA 442
Query: 440 FQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTF 487
FQDA+GYAYFLRG LYWKFDPVKVK LE FPR +GPDFF CAEPANTF
Sbjct: 443 FQDAEGYAYFLRGHLYWKFDPVKVKVLESFPRPIGPDFFDCAEPANTF 490
>ref|NP_037112.1| matrix metalloproteinase 11 (stromelysin 3) [Rattus norvegicus]
gb|AAC53061.1| (U46034) stromelysin 3 [Rattus norvegicus]
Length = 458
Score = 773 bits (1975), Expect = 0.0
Identities = 359/408 (87%), Positives = 376/408 (91%), Gaps = 1/408 (0%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGVPDP D L+ARNRQKRFVLSGGRWEKTDLTYRILRFPWQLV+EQVRQT+AEAL+VWS+
Sbjct: 51 CGVPDPPDVLNARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALRVWSE 110
Query: 140 VTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 199
VTPLTFTEVHEGRADIMIDF RYWHGD+LPFDGPGGILAHAFFPKTHREGDVHFDYDETW
Sbjct: 111 VTPLTFTEVHEGRADIMIDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 170
Query: 200 TIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQ 259
TIGD +GTDLLQVAAHEFGHVLGLQHTTAAKALMS FYTFRYPLSLSPDD RG+QHLYG+
Sbjct: 171 TIGD-KGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGR 229
Query: 260 PWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRL 319
P T TS TP L QAG DTNEIA EP+ PP+ CE SFDAVSTIRGELFFFKAGFVWRL
Sbjct: 230 PQLTPTSPTPTLSSQAGTDTNEIALQEPEVPPEVCETSFDAVSTIRGELFFFKAGFVWRL 289
Query: 320 RGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTE 379
R GQLQPGYPALASRHWQGLPSPVDAAFEDAQG IWFFQGAQYWVYDGEKPVLGPAPL++
Sbjct: 290 RSGQLQPGYPALASRHWQGLPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSK 349
Query: 380 LGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAA 439
LGL PVHAALVWGPEKNKIYFFRG DYWRFHP T+RVD+PVPRR TDWRGVPSEIDAA
Sbjct: 350 LGLQGSPVHAALVWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRTTDWRGVPSEIDAA 409
Query: 440 FQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTF 487
FQDA+GYAYFLRG LYWKFDPVKVK LE FPR +GPDFF CAEPANTF
Sbjct: 410 FQDAEGYAYFLRGHLYWKFDPVKVKVLESFPRPIGPDFFDCAEPANTF 457
>sp|Q11005|COGY_XENLA STROMELYSIN-3 PRECURSOR (MATRIX METALLOPROTEINASE-11) (MMP-11)
(ST3)
pir||I51645 stromelysin 3 (EC 3.4.24.-) - African clawed frog
emb|CAA81616.1| (Z27093) stromelysin-3 [Xenopus laevis]
Length = 477
Score = 603 bits (1539), Expect = e-171
Identities = 281/414 (67%), Positives = 336/414 (80%), Gaps = 10/414 (2%)
Query: 80 CGVPD---PSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKV 136
CGVPD P D S RNRQKRFVLSGGRW+KT+LTY+I+RFPWQL + +VR+T+AEALKV
Sbjct: 65 CGVPDIPAPPDSSSGRNRQKRFVLSGGRWDKTNLTYKIIRFPWQLSKVKVRRTIAEALKV 124
Query: 137 WSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYD 196
WS+VTPLTFTEVHEGR+DI+IDF RYWHGD+LPFDGPGGILAHAFFPKTHREGDVHFDYD
Sbjct: 125 WSEVTPLTFTEVHEGRSDIIIDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYD 184
Query: 197 ETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHL 256
E WTIG++ GTDLLQVAAHEFGH+LGLQH++ +K+LMS FYTFRYPLSLS DD G+Q L
Sbjct: 185 EAWTIGNNIGTDLLQVAAHEFGHMLGLQHSSISKSLMSPFYTFRYPLSLSADDKHGIQFL 244
Query: 257 YGQPWPTVTSRTPALG-PQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGF 315
YG P P S TP + Q ++NEI P A PDAC+ +FDAVSTIRGELFFFK+G+
Sbjct: 245 YGAPRPPTPSPTPRVEVNQVENESNEI----PAAEPDACKTNFDAVSTIRGELFFFKSGY 300
Query: 316 VWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPA 375
VWRLRGG+LQ GYPALASRHW+G+P VDAAFED+ G+IWFF G+Q+WV+DG+ GP
Sbjct: 301 VWRLRGGKLQNGYPALASRHWRGIPDTVDAAFEDSVGNIWFFYGSQFWVFDGKLQASGPF 360
Query: 376 PLTELGLVRFPVHAALVWGPEKN-KIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPS 434
P+T++G+ + AA VWG EKN K Y FRG +YWRF+P TRRV+S RR DWRGVP
Sbjct: 361 PITDIGISVTQIQAAFVWGTEKNKKTYLFRGGEYWRFNPETRRVESRHSRRIGDWRGVPK 420
Query: 435 EIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL 488
IDAAFQD GYAYF++GR YWKFDP KV+ ++G+P L+ DFF C + ++TF+
Sbjct: 421 GIDAAFQDEQGYAYFVKGRQYWKFDPFKVRVMDGYPHLISQDFFNC-QASSTFV 473
>dbj|BAA82966.1| (AB021226) membrane-type-5 matrix metalloproteinase [Mus musculus]
Length = 618
Score = 311 bits (788), Expect = 1e-83
Identities = 176/435 (40%), Positives = 236/435 (53%), Gaps = 34/435 (7%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGVPD LS R R KR+ L+G +W + +TY I + ++ + R+ + +A VW
Sbjct: 112 CGVPDHPH-LSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQK 170
Query: 140 VTPLTFTEV--HEGR-----ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVH 192
VTPLTF EV HE + ADIMI FA +HGD PFDG GG LAHA+FP GD H
Sbjct: 171 VTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTH 230
Query: 193 FDYDETWTIGD--DQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFR--YPLSLSPD 248
FD DE WT+G+ G DL VA HE GH LGL+H+ A+M+ FY + + L D
Sbjct: 231 FDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETHNFKLPQD 290
Query: 249 DCRGVQHLYG---------QPWPTV--------TSRTPALGPQAGIDTNEIAPLEPDAPP 291
D +G+Q +YG +P PT+ + R P+ P P A P
Sbjct: 291 DLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERHPRPPRPPLGDRPSTPGAKP 350
Query: 292 DACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQ 351
+ C+ +F+ V+ RGE+F FK + WRLR ++Q GYP + W+GLP+ +DAA+E A
Sbjct: 351 NICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERAD 410
Query: 352 GHIWFFQGAQYWVYDGEKPVLG-PAPLTELG--LVRFPVHAALVWGPEKNKIYFFRGRDY 408
G FF+G +YWV+ G P L ELG L R + AL W P K YFF+G Y
Sbjct: 411 GRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEP-VGKTYFFKGERY 469
Query: 409 WRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALE 467
WR+ R D P+ T W+G+P AF +G Y YF +GR YWKFD K+
Sbjct: 470 WRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEP 529
Query: 468 GFPRLVGPDFFGCAE 482
G+PR + D+ GC +
Sbjct: 530 GYPRNILRDWMGCKQ 544
>ref|NP_006681.1| matrix metalloproteinase 24 (membrane-inserted) [Homo sapiens]
gb|AAD42962.1|AF131284_1 (AF131284) membrane type 5 matrix metalloproteinase [Homo sapiens]
dbj|BAA82967.1| (AB021227) membrane-type-5 matrix metalloproteinase [Homo sapiens]
Length = 645
Score = 309 bits (784), Expect = 4e-83
Identities = 175/433 (40%), Positives = 235/433 (53%), Gaps = 34/433 (7%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGVPD LS R R KR+ L+G +W + +TY I + ++ + R+ + +A VW
Sbjct: 139 CGVPDHPH-LSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQK 197
Query: 140 VTPLTFTEV--HEGR-----ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVH 192
VTPLTF EV HE + ADIMI FA +HGD PFDG GG LAHA+FP GD H
Sbjct: 198 VTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTH 257
Query: 193 FDYDETWTIGD--DQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFR--YPLSLSPD 248
FD DE WT+G+ G DL VA HE GH LGL+H++ A+M+ FY + + L D
Sbjct: 258 FDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQD 317
Query: 249 DCRGVQHLYG---------QPWPTV--------TSRTPALGPQAGIDTNEIAPLEPDAPP 291
D +G+Q +YG +P PT+ + R P+ P P P
Sbjct: 318 DLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKP 377
Query: 292 DACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQ 351
+ C+ +F+ V+ RGE+F FK + WRLR ++Q GYP + W+GLP+ +DAA+E A
Sbjct: 378 NICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERAD 437
Query: 352 GHIWFFQGAQYWVYDGEKPVLG-PAPLTELG--LVRFPVHAALVWGPEKNKIYFFRGRDY 408
G FF+G +YWV+ G P L ELG L R + AL W P K YFF+G Y
Sbjct: 438 GRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEP-VGKTYFFKGERY 496
Query: 409 WRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALE 467
WR+ R D P+ T W+G+P AF +G Y YF +GR YWKFD K+
Sbjct: 497 WRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEP 556
Query: 468 GFPRLVGPDFFGC 480
G+PR + D+ GC
Sbjct: 557 GYPRNILRDWMGC 569
>ref|NP_034938.1| matrix metalloproteinase 24; Membrane type 5-MMP [Mus musculus]
emb|CAA09055.1| (AJ010262) MT5-MMP protein [Mus musculus]
Length = 614
Score = 304 bits (771), Expect = 1e-81
Identities = 174/435 (40%), Positives = 232/435 (53%), Gaps = 34/435 (7%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGVPD LS R R KR+ L+G +W + +TY I + ++ + R+ + +A VW
Sbjct: 108 CGVPDHPH-LSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQK 166
Query: 140 VTPLTFTEV--HEGR-----ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVH 192
VTPLTF EV HE + ADIMI FA +HGD PFDG GG LAHA+FP GD H
Sbjct: 167 VTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTH 226
Query: 193 FDYDETWTIGD--DQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFR--YPLSLSPD 248
FD DE WT+G+ G DL VA HE GH LGL+H+ A+M+ FY + + L D
Sbjct: 227 FDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETHNFKLPQD 286
Query: 249 DCRGVQHLYGQPW-PTVTSRTPALGPQAGIDTNEIA---------------PLEPDAPPD 292
D +G+Q +YG P P+ +R P I + P P A P+
Sbjct: 287 DLQGIQKIYGPPAEPSGATRPLPTLPVRRIHSPSEKKHERHPRPPRRPWGRPSTPGAKPN 346
Query: 293 ACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQG 352
C+ +F+ V+ RGE+F FK + WRLR ++Q GYP + W+GLP+ +DAA+E A G
Sbjct: 347 ICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADG 406
Query: 353 HIWFFQGAQYWVYDGEKPVLG-PAPLTELGLV---RFPVHAALVWGPEKNKIYFFRGRDY 408
FF+G +YWV+ G P L ELG AL W P K YFF+G Y
Sbjct: 407 RFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGKPDTALRWEP-VGKTYFFKGERY 465
Query: 409 WRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALE 467
WR+ R D P+ T W+G+P AF +G Y YF +GR YWKFD K+
Sbjct: 466 WRYSEERRATDPGYPKPITVWKGIPQAPQGAFLSKEGYYTYFYKGRDYWKFDNQKLSVEP 525
Query: 468 GFPRLVGPDFFGCAE 482
G+PR + D+ GC +
Sbjct: 526 GYPRNILRDWMGCKQ 540
>gb|AAB51753.1| (U54984) membrane-type matrix metalloproteinase 1 [Mus musculus]
Length = 582
Score = 295 bits (747), Expect = 8e-79
Identities = 161/421 (38%), Positives = 230/421 (54%), Gaps = 25/421 (5%)
Query: 80 CGVPDP-SDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 93 CGVPDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWE 152
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H+ A+MS FY + + L
Sbjct: 213 THFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMSPFYQWMDTENFVLP 272
Query: 247 PDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAP---PDACEASFDAVST 303
DD RG+Q LYG + T + PQ + P +P P P+ C+ +FD V+
Sbjct: 273 DDDRRGIQQLYGSKSGSPTK----MPPQPRTTSRPSVPDKPKNPAYGPNICDGNFDTVAM 328
Query: 304 IRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYW 363
+RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++W
Sbjct: 329 LRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHW 388
Query: 364 VYDGEKPVLG-PAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS 420
V+D G P + EL GL + AAL W P K YFFRG Y+RF+ R VDS
Sbjct: 389 VFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEEFRAVDS 447
Query: 421 PVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFG 479
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ G
Sbjct: 448 EYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMG 507
Query: 480 C 480
C
Sbjct: 508 C 508
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 476 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 510
>ref|NP_004986.1| matrix metalloproteinase 14 (membrane-inserted) [Homo sapiens]
pir||I38028 matrix metalloproteinase 14 (EC 3.4.24.-) membrane type precursor -
human
emb|CAA88372.1| (Z48481) membrane-type matrix metalloproteinase 1 [Homo sapiens]
gb|AAA83770.1| (U41078) membrane-type matrix metalloproteinase-1 [Homo sapiens]
Length = 582
Score = 294 bits (746), Expect = 1e-78
Identities = 159/420 (37%), Positives = 229/420 (53%), Gaps = 23/420 (5%)
Query: 80 CGVPDPSDG-LSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 93 CGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWE 152
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H++ A+M+ FY + + L
Sbjct: 213 THFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLP 272
Query: 247 PDDCRGVQHLYG--QPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTI 304
DD RG+Q LYG +PT P + + P P P+ C+ +FD V+ +
Sbjct: 273 DDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDK---PKNPTYGPNICDGNFDTVAML 329
Query: 305 RGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWV 364
RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++WV
Sbjct: 330 RGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWV 389
Query: 365 YDGEKPVLG-PAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSP 421
+D G P + EL GL + AAL W P K YFFRG Y+RF+ R VDS
Sbjct: 390 FDEASLEPGYPKHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEELRAVDSE 448
Query: 422 VPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ GC
Sbjct: 449 YPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC 508
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 476 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 510
>pir||I38046 MT-MMP - human
emb|CAA58519.1| (X83535) MT-MMP [Homo sapiens]
Length = 582
Score = 294 bits (746), Expect = 1e-78
Identities = 159/420 (37%), Positives = 229/420 (53%), Gaps = 23/420 (5%)
Query: 80 CGVPDPSDG-LSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 93 CGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWE 152
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H++ A+M+ FY + + L
Sbjct: 213 THFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLP 272
Query: 247 PDDCRGVQHLYG--QPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTI 304
DD RG+Q LYG +PT P + + P P P+ C+ +FD V+ +
Sbjct: 273 DDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDK---PKNPTYGPNICDGNFDTVAML 329
Query: 305 RGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWV 364
RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++WV
Sbjct: 330 RGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWV 389
Query: 365 YDGEKPVLG-PAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSP 421
+D G P + EL GL + AAL W P K YFFRG Y+RF+ R VDS
Sbjct: 390 FDEASLEPGYPKHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEELRAVDSE 448
Query: 422 VPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ GC
Sbjct: 449 YPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC 508
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 476 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 510
>sp|P50281|COGT_HUMAN MATRIX METALLOPROTEINASE-14 PRECURSOR (MMP-14) (MEMBRANE-TYPE
MATRIX METALLOPROTEINASE 1) (MT-MMP 1) (MTMMP1)
dbj|BAA05519.1| (D26512) MT-MMP [Homo sapiens]
Length = 582
Score = 294 bits (746), Expect = 1e-78
Identities = 159/420 (37%), Positives = 229/420 (53%), Gaps = 23/420 (5%)
Query: 80 CGVPDPSDG-LSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 93 CGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWE 152
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H++ A+M+ FY + + L
Sbjct: 213 THFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLP 272
Query: 247 PDDCRGVQHLYG--QPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTI 304
DD RG+Q LYG +PT P + + P P P+ C+ +FD V+ +
Sbjct: 273 DDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDK---PKNPTYGPNICDGNFDTVAML 329
Query: 305 RGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWV 364
RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++WV
Sbjct: 330 RGEMFVFKKRWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWV 389
Query: 365 YDGEKPVLG-PAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSP 421
+D G P + EL GL + AAL W P K YFFRG Y+RF+ R VDS
Sbjct: 390 FDEASLEPGYPKHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEELRAVDSE 448
Query: 422 VPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ GC
Sbjct: 449 YPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC 508
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 476 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 510
>gb|AAB86602.1| (AF022432) matrix metalloproteinase-14 [Mus musculus]
Length = 581
Score = 294 bits (745), Expect = 1e-78
Identities = 159/420 (37%), Positives = 228/420 (53%), Gaps = 24/420 (5%)
Query: 80 CGVPDP-SDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + + + + + +A +VW
Sbjct: 93 CGVPDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYTSKXGEXXTFEXIRKAFRVWE 152
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H+ A+M+ FY + + L
Sbjct: 213 THFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLP 272
Query: 247 PDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAP---PDACEASFDAVST 303
DD RG+Q LYG + T + PQ + P +P P P+ C+ +FD V+
Sbjct: 273 DDDRRGIQQLYGSKSGSPTK----MPPQPRTTSRPSVPDKPKNPAYGPNICDGNFDTVAM 328
Query: 304 IRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYW 363
+RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++W
Sbjct: 329 LRGEMFVFKERWFWRVRPNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHW 388
Query: 364 VYDGEKPVLGPAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSP 421
V+D P + EL GL + AAL W P K YFFRG Y+RF+ R VDS
Sbjct: 389 VFDEASLEPVPKHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEEFRAVDSE 447
Query: 422 VPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ GC
Sbjct: 448 YPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC 507
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 475 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 509
>emb|CAA62432.1| (X90925) MT-MMP protein [Homo sapiens]
Length = 582
Score = 294 bits (745), Expect = 1e-78
Identities = 159/420 (37%), Positives = 229/420 (53%), Gaps = 23/420 (5%)
Query: 80 CGVPDPSDG-LSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 93 CGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWE 152
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H++ A+M+ FY + + L
Sbjct: 213 THFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLP 272
Query: 247 PDDCRGVQHLYG--QPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTI 304
DD RG+Q LYG +PT P + + P P P+ C+ +FD V+ +
Sbjct: 273 DDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDK---PKNPTYGPNICDGNFDTVAML 329
Query: 305 RGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWV 364
RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++WV
Sbjct: 330 RGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWV 389
Query: 365 YDGEKPVLG-PAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSP 421
+D G P + EL GL + AAL W P K YFFRG Y+RF+ R VDS
Sbjct: 390 FDEASLEPGYPKHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEELRAVDSE 448
Query: 422 VPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ GC
Sbjct: 449 YPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKPALRDWMGC 508
Score = 33.2 bits (74), Expect = 6.7
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 476 YFYKGNKYWKFNNQKLKVEPGYPKPALRDWMGCPS 510
>gb|AAD13803.1| (U73940) membane-type 1 metalloproteinase precursor [Oryctolagus
cuniculus]
Length = 572
Score = 293 bits (743), Expect = 2e-78
Identities = 163/427 (38%), Positives = 229/427 (53%), Gaps = 37/427 (8%)
Query: 80 CGVPDPSDG-LSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 93 CGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWE 152
Query: 139 DVTPLTFTEVH--------EGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EVH E +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVHYAYIRDGREKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H+ A+M+ FY + + L
Sbjct: 213 THFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLP 272
Query: 247 PDDCRGVQHLYGQ---------PWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEAS 297
DD RG+Q LYG P P TSRT P P P P+ C+ +
Sbjct: 273 DDDRRGIQQLYGSQSGSPTKMPPPPRTTSRT--FIPDK--------PRNPTYGPNICDGN 322
Query: 298 FDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFF 357
FD V+ +RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF
Sbjct: 323 FDTVAVLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFF 382
Query: 358 QGAQYWVYDGEKPVLG-PAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPS 414
+G ++WV+D G P + EL GL + AAL W P K YFFRG Y+RF+
Sbjct: 383 KGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEE 441
Query: 415 TRRVDSPVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLV 473
R VDS P+ W G+P +F +D + YF +G YWKF+ K+K G+P+
Sbjct: 442 LRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSA 501
Query: 474 GPDFFGC 480
D+ GC
Sbjct: 502 LRDWMGC 508
>emb|CAA62897.1| (X91785) membrane-type metalloproteinase [Rattus norvegicus]
Length = 582
Score = 293 bits (743), Expect = 2e-78
Identities = 160/421 (38%), Positives = 230/421 (54%), Gaps = 25/421 (5%)
Query: 80 CGVPDP-SDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 93 CGVPDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWE 152
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H+ A+M+ FY + + L
Sbjct: 213 THFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLP 272
Query: 247 PDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAP---PDACEASFDAVST 303
DD RG+Q LYG + T + PQ + P +P P P+ C+ +FD V+
Sbjct: 273 DDDRRGIQQLYGSKSGSPTK----MPPQPRTTSRPSVPDKPRNPTYGPNICDGNFDTVAM 328
Query: 304 IRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYW 363
+RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++W
Sbjct: 329 LRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHW 388
Query: 364 VYDGEKPVLG-PAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS 420
V+D G P + EL GL + AAL W P K YFFRG Y+RF+ R VDS
Sbjct: 389 VFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEEFRAVDS 447
Query: 421 PVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFG 479
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ G
Sbjct: 448 EYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMG 507
Query: 480 C 480
C
Sbjct: 508 C 508
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 476 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 510
>ref|NP_062698.1| membrane-type-3 matrix metalloproteinase [Mus musculus]
dbj|BAA78420.1| (AB021228) membrane-type-3 matrix metalloproteinase [Mus musculus]
Length = 607
Score = 293 bits (742), Expect = 3e-78
Identities = 161/438 (36%), Positives = 231/438 (51%), Gaps = 33/438 (7%)
Query: 80 CGVPDPSDGLSARN-RQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + G S N R+KR+ L+G +W+ +TY I ++ + R+ + A VW
Sbjct: 101 CGVPDQTRGSSKFNIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRRAIRRAFDVWQ 160
Query: 139 DVTPLTFTEV-----HEGR--ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDV 191
+VTPLTF EV G+ DI I FA +HGD PFDG GG LAHA+FP GD
Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220
Query: 192 HFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSP 247
HFD DE WT+G+ G DL VA HE GH LGL+H+ A+M+ FY + L
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
Query: 248 DDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIA--------------PLEPDAPP 291
DD +G+Q +YG P P T P + P + + P P A P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSVPPADPRRHDRPKPPRPPTGRPSYPGAKP 340
Query: 292 DACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQ 351
+ C+ +F+ ++ +R E+F FK + WR+R ++ GYP + W+GLP +DA +E++
Sbjct: 341 NICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
Query: 352 GHIWFFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHA--ALVWGPEKNKIYFFRGRDY 408
G+ FF+G +YWV+ G P L LG P H + +W + K YFF+G Y
Sbjct: 401 GNFVFFKGNKYWVFKDTTLQPGYPHDLITLG-NGIPPHGIDSAIWWEDVGKTYFFKGDRY 459
Query: 409 WRFHPSTRRVDSPVPRRATDWRGVPSEIDAAF-QDADGYAYFLRGRLYWKFDPVKVKALE 467
WR+ + +D P+ T W+G+P AF +G+ YF +G+ YWKF+ +K
Sbjct: 460 WRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEP 519
Query: 468 GFPRLVGPDFFGCAEPAN 485
G+PR + DF GC P +
Sbjct: 520 GYPRSILKDFMGCDGPTD 537
>gb|AAD38324.1|AF067419_1 (AF067419) membrane-type 1 matrix metalloproteinase [Sus scrofa]
Length = 580
Score = 293 bits (741), Expect = 4e-78
Identities = 159/420 (37%), Positives = 228/420 (53%), Gaps = 23/420 (5%)
Query: 80 CGVPDPSDG-LSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 91 CGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWE 150
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 151 SATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 210
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H+ A+M+ FY + + L
Sbjct: 211 THFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLP 270
Query: 247 PDDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTI 304
DD RG+Q LYG +PT P + + P P P+ C+ +FD V+ +
Sbjct: 271 DDDRRGIQQLYGSESGFPTKMPPQPRTTSKPSVPDK---PKNPTYGPNICDGNFDTVAML 327
Query: 305 RGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWV 364
RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++WV
Sbjct: 328 RGEMFVFKERWFWRVRKNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWV 387
Query: 365 YDGEKPVLG-PAPLTELG--LVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSP 421
+D G P + ELG L + AAL W P K YFFRG Y+RF+ R VDS
Sbjct: 388 FDEASLEPGYPKHIKELGRRLPTDKIDAALFWMP-NGKDYFFRGNKYYRFNEELRAVDSE 446
Query: 422 VPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ GC
Sbjct: 447 YPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC 506
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 474 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 508
>sp|Q95220|COGT_RABIT MATRIX METALLOPROTEINASE-14 PRECURSOR (MMP-14) (MEMBRANE-TYPE
MATRIX METALLOPROTEINASE 1) (MT-MMP 1) (MTMMP1)
gb|AAB41500.1| (U83918) membrane type 1 metalloproteinase [Oryctolagus cuniculus]
Length = 582
Score = 293 bits (741), Expect = 4e-78
Identities = 159/418 (38%), Positives = 227/418 (54%), Gaps = 19/418 (4%)
Query: 80 CGVPDPSDG-LSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 93 CGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWE 152
Query: 139 DVTPLTFTEVH--------EGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EVH E +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVHYAYIRDGREKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFR--YPLSLS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H+ A+M+ FY + L
Sbjct: 213 THFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTEKFLLP 272
Query: 247 PDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRG 306
D+ RG+Q LYG + T G +G+ I+P P P C+ +FD V+ RG
Sbjct: 273 DDERRGIQQLYGSQSGSPTRCLLNPGQPSGL-LFRISPGNPTYGPKICDGNFDTVAVFRG 331
Query: 307 ELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYD 366
E+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++WV+D
Sbjct: 332 EMFVFKERWFWRVRNNQVMDGYPMPIGQLWRGLPASINTAYERKDGKFVFFKGDKHWVFD 391
Query: 367 GEKPVLG-PAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVP 423
G P + EL GL + AAL W P K YFFRG Y+RF+ R VDS P
Sbjct: 392 EASLEPGYPKHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEELRAVDSEYP 450
Query: 424 RRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480
+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ GC
Sbjct: 451 KNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC 508
>gb|AAG17704.1|AF282844_1 (AF282844) matrix metalloproteinase 16 [Mus musculus]
Length = 607
Score = 292 bits (740), Expect = 5e-78
Identities = 161/438 (36%), Positives = 231/438 (51%), Gaps = 33/438 (7%)
Query: 80 CGVPDPSDGLSARN-RQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + G S N R+KR+ L+G +W+ +TY I ++ + R+ + A VW
Sbjct: 101 CGVPDQTRGSSKFNIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRRAIRRAFDVWQ 160
Query: 139 DVTPLTFTEV-----HEGR--ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDV 191
+VTPLTF EV G+ DI I FA +HGD PFDG GG LAHA+FP GD
Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDRSPFDGEGGFLAHAYFPGPGIGGDT 220
Query: 192 HFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSP 247
HFD DE WT+G+ G DL VA HE GH LGL+H+ A+M+ FY + L
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
Query: 248 DDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIA--------------PLEPDAPP 291
DD +G+Q +YG P P T P + P + + P P A P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSVPPADPRRHDRPKPPRPPTGRPSYPGAKP 340
Query: 292 DACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQ 351
+ C+ +F+ ++ +R E+F FK + WR+R ++ GYP + W+GLP +DA +E++
Sbjct: 341 NICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
Query: 352 GHIWFFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHA--ALVWGPEKNKIYFFRGRDY 408
G+ FF+G +YWV+ G P L LG P H + +W + K YFF+G Y
Sbjct: 401 GNFVFFKGNKYWVFKDTTLQPGYPHDLITLG-NGIPPHGIDSAIWWEDVGKTYFFKGDRY 459
Query: 409 WRFHPSTRRVDSPVPRRATDWRGVPSEIDAAF-QDADGYAYFLRGRLYWKFDPVKVKALE 467
WR+ + +D P+ T W+G+P AF +G+ YF +G+ YWKF+ +K
Sbjct: 460 WRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEP 519
Query: 468 GFPRLVGPDFFGCAEPAN 485
G+PR + DF GC P +
Sbjct: 520 GYPRSILKDFMGCDGPTD 537
>gb|AAF66697.2|AF145442_1 (AF145442) leukolysin [Homo sapiens]
emb|CAB94713.1| (AJ239053) matrix metalloproteinase-25 [Homo sapiens]
emb|CAC03490.1| (AJ272137) membrane type matrix metalloproteinase number 6 [Homo
sapiens]
gb|AAG17007.1|AF185270_1 (AF185270) leukolysin [Homo sapiens]
Length = 562
Score = 292 bits (740), Expect = 5e-78
Identities = 177/427 (41%), Positives = 225/427 (52%), Gaps = 24/427 (5%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPW--QLVQEQVRQTMAEALKVW 137
C +PD R++R+ LSG W+K LT+R+ FP QL QE VR M+ AL W
Sbjct: 90 CSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAW 149
Query: 138 SDVTPLTFTEVHEGRA---DIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHR-EGDVHF 193
+ LTF EV + DI+IDFAR +H D PFDG GG LAHAFFP H GD HF
Sbjct: 150 GMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHF 209
Query: 194 DYDETWTIG--DDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS------L 245
D +ETWT G D +GTDL VA HEFGH LGL H++A ++M FY + P+ L
Sbjct: 210 DDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFY--QGPVGDPDKYRL 267
Query: 246 SPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLE-PDAP-PDACEASFDAVST 303
S DD G+Q LYG+ P P P A +P P P PD CE +FDA++
Sbjct: 268 SQDDRDGLQQLYGKA-PQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDAIAN 326
Query: 304 IRGELFFFKAGFVWRLR-GGQLQPGYPALASRHWQGLPSPV---DAAF-EDAQGHIWFFQ 358
IRGE FFFK + WRL+ GQL PA R W+GLP+ V AA+ G I F
Sbjct: 327 IRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFS 386
Query: 359 GAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRV 418
G Q+WV+ + G PLTELGL A+ P+ K Y RGR YWR+ + R
Sbjct: 387 GPQFWVFQDRQLEGGARPLTELGLPPGEEVDAVFSWPQNGKTYLVRGRQYWRYDEAAARP 446
Query: 419 DSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFF 478
D PR + W G P D G YF +G YW+F +K P+ +GP++
Sbjct: 447 DPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWL 506
Query: 479 GCAEPAN 485
C P++
Sbjct: 507 DCPAPSS 513
>sp|O35548|COGV_RAT MATRIX METALLOPROTEINASE-16 PRECURSOR (MMP-16) (MEMBRANE-TYPE
MATRIX METALLOPROTEINASE 3) (MT-MMP 3) (MTMMP3)
dbj|BAA22224.1| (D85509) MT3-MMP [Rattus rattus]
Length = 607
Score = 292 bits (740), Expect = 5e-78
Identities = 161/438 (36%), Positives = 231/438 (51%), Gaps = 33/438 (7%)
Query: 80 CGVPDPSDGLSARN-RQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + G S N R+KR+ L+G +W+ +TY I ++ + R+ + A VW
Sbjct: 101 CGVPDQTRGSSKFNIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRRAIRRAFDVWQ 160
Query: 139 DVTPLTFTEV-----HEGR--ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDV 191
+VTPLTF EV G+ DI I FA +HGD PFDG GG LAHA+FP GD
Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDRSPFDGEGGFLAHAYFPGPGIGGDT 220
Query: 192 HFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSP 247
HFD DE WT+G+ G DL VA HE GH LGL+H+ A+M+ FY + L
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
Query: 248 DDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIA--------------PLEPDAPP 291
DD +G+Q +YG P P T P + P + + P P A P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSVPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
Query: 292 DACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQ 351
+ C+ +F+ ++ +R E+F FK + WR+R ++ GYP + W+GLP +DA +E++
Sbjct: 341 NICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
Query: 352 GHIWFFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHA--ALVWGPEKNKIYFFRGRDY 408
G+ FF+G +YWV+ G P L LG P H + +W + K YFF+G Y
Sbjct: 401 GNFVFFKGNKYWVFKDTTLQPGYPHDLITLG-NGIPPHGIDSAIWWEDVGKTYFFKGDRY 459
Query: 409 WRFHPSTRRVDSPVPRRATDWRGVPSEIDAAF-QDADGYAYFLRGRLYWKFDPVKVKALE 467
WR+ + +D P+ T W+G+P AF +G+ YF +G+ YWKF+ +K
Sbjct: 460 WRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEP 519
Query: 468 GFPRLVGPDFFGCAEPAN 485
G+PR + DF GC P +
Sbjct: 520 GYPRSILKDFMGCDGPTD 537
>dbj|BAA22223.1| (D63886) MT3-MMP-del [Rattus sp.]
Length = 547
Score = 292 bits (740), Expect = 5e-78
Identities = 161/438 (36%), Positives = 231/438 (51%), Gaps = 33/438 (7%)
Query: 80 CGVPDPSDGLSARN-RQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + G S N R+KR+ L+G +W+ +TY I ++ + R+ + A VW
Sbjct: 101 CGVPDQTRGSSKFNIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRRAIRRAFDVWQ 160
Query: 139 DVTPLTFTEV-----HEGR--ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDV 191
+VTPLTF EV G+ DI I FA +HGD PFDG GG LAHA+FP GD
Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDRSPFDGEGGFLAHAYFPGPGIGGDT 220
Query: 192 HFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSP 247
HFD DE WT+G+ G DL VA HE GH LGL+H+ A+M+ FY + L
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
Query: 248 DDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIA--------------PLEPDAPP 291
DD +G+Q +YG P P T P + P + + P P A P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSVPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
Query: 292 DACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQ 351
+ C+ +F+ ++ +R E+F FK + WR+R ++ GYP + W+GLP +DA +E++
Sbjct: 341 NICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
Query: 352 GHIWFFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHA--ALVWGPEKNKIYFFRGRDY 408
G+ FF+G +YWV+ G P L LG P H + +W + K YFF+G Y
Sbjct: 401 GNFVFFKGNKYWVFKDTTLQPGYPHDLITLG-NGIPPHGIDSAIWWEDVGKTYFFKGDRY 459
Query: 409 WRFHPSTRRVDSPVPRRATDWRGVPSEIDAAF-QDADGYAYFLRGRLYWKFDPVKVKALE 467
WR+ + +D P+ T W+G+P AF +G+ YF +G+ YWKF+ +K
Sbjct: 460 WRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEP 519
Query: 468 GFPRLVGPDFFGCAEPAN 485
G+PR + DF GC P +
Sbjct: 520 GYPRSILKDFMGCDGPTD 537
>sp|P51512|COGV_HUMAN MATRIX METALLOPROTEINASE-16 PRECURSOR (MMP-16) (MEMBRANE-TYPE
MATRIX METALLOPROTEINASE 3) (MT-MMP 3) (MTMMP3) (MMP-X2)
dbj|BAA12022.1| (D83646) metalloproteinase [Homo sapiens]
dbj|BAA22226.1| (D85511) MT3-MMP [Homo sapiens]
Length = 607
Score = 292 bits (739), Expect = 7e-78
Identities = 161/438 (36%), Positives = 231/438 (51%), Gaps = 33/438 (7%)
Query: 80 CGVPDPSDGLSARN-RQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + G S + R+KR+ L+G +W+ +TY I ++ + R+ + A VW
Sbjct: 101 CGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160
Query: 139 DVTPLTFTEV-----HEGR--ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDV 191
+VTPLTF EV G+ DI I FA +HGD PFDG GG LAHA+FP GD
Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220
Query: 192 HFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSP 247
HFD DE WT+G+ G DL VA HE GH LGL+H+ A+M+ FY + L
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
Query: 248 DDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIA--------------PLEPDAPP 291
DD +G+Q +YG P P T P + P I + P P A P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
Query: 292 DACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQ 351
+ C+ +F+ ++ +R E+F FK + WR+R ++ GYP + W+GLP +DA +E++
Sbjct: 341 NICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
Query: 352 GHIWFFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHA--ALVWGPEKNKIYFFRGRDY 408
G+ FF+G +YWV+ G P L LG P H + +W + K YFF+G Y
Sbjct: 401 GNFVFFKGNKYWVFKDTTLQPGYPHDLITLG-SGIPPHGIDSAIWWEDVGKTYFFKGDRY 459
Query: 409 WRFHPSTRRVDSPVPRRATDWRGVPSEIDAAF-QDADGYAYFLRGRLYWKFDPVKVKALE 467
WR+ + +D P+ T W+G+P AF +G+ YF +G+ YWKF+ +K
Sbjct: 460 WRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEP 519
Query: 468 GFPRLVGPDFFGCAEPAN 485
G+PR + DF GC P +
Sbjct: 520 GYPRSILKDFMGCDGPTD 537
>sp|Q10739|COGT_RAT MATRIX METALLOPROTEINASE-14 PRECURSOR (MMP-14) (MEMBRANE-TYPE
MATRIX METALLOPROTEINASE 1) (MT-MMP 1) (MTMMP1)
pir||I84471 matrix metalloproteinase (EC 3.4.24.-) membrane type precursor -
rat
emb|CAA58521.1| (X83537) MT-MMP [Rattus norvegicus]
Length = 582
Score = 291 bits (737), Expect = 1e-77
Identities = 159/421 (37%), Positives = 229/421 (53%), Gaps = 25/421 (5%)
Query: 80 CGVPDP-SDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 93 CGVPDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWE 152
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H+ +M+ FY + + L
Sbjct: 213 THFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSDIMAPFYQWMDTENFVLP 272
Query: 247 PDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAP---PDACEASFDAVST 303
DD RG+Q LYG + T + PQ + P +P P P+ C+ +FD V+
Sbjct: 273 DDDRRGIQQLYGSKSGSPTK----MPPQPRTTSRPSVPDKPRNPTYGPNICDGNFDTVAM 328
Query: 304 IRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYW 363
+RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++W
Sbjct: 329 LRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHW 388
Query: 364 VYDGEKPVLG-PAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS 420
V+D G P + EL GL + AAL W P K YFFRG Y+RF+ R VDS
Sbjct: 389 VFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEEFRAVDS 447
Query: 421 PVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFG 479
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ G
Sbjct: 448 EYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMG 507
Query: 480 C 480
C
Sbjct: 508 C 508
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 476 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 510
>gb|AAG28170.1|AF290429_1 (AF290429) membrane-type matrix metalloprotease 1 [Bos taurus]
Length = 582
Score = 291 bits (736), Expect = 2e-77
Identities = 159/421 (37%), Positives = 229/421 (53%), Gaps = 25/421 (5%)
Query: 80 CGVPDPSDG-LSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + + + + + +A +VW
Sbjct: 92 CGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPNVGEYATFEAIRKAFRVWE 151
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 152 SATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 211
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H+ A+M+ FY + + L
Sbjct: 212 THFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLP 271
Query: 247 PDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAP---PDACEASFDAVST 303
DD RG+Q LYG + T + PQ + P +P P P+ C+ +FD V+
Sbjct: 272 DDDRRGIQQLYGSKSGSPTK----MPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAM 327
Query: 304 IRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYW 363
+RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++W
Sbjct: 328 LRGEMFVFKERWFWRVRKNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHW 387
Query: 364 VYDGEKPVLG-PAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS 420
V+D G P + EL GL + AAL W P K YFFRG Y+RF+ R V+S
Sbjct: 388 VFDEASLEPGYPKHIKELGRGLPTDRIDAALFWMP-NGKTYFFRGNKYYRFNEELRIVES 446
Query: 421 PVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFG 479
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ G
Sbjct: 447 EYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMG 506
Query: 480 C 480
C
Sbjct: 507 C 507
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 475 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 509
>dbj|BAA36551.1| (AB010921) Membrane-type matrix metalloproteinase-1 [Capra hircus]
Length = 582
Score = 290 bits (735), Expect = 2e-77
Identities = 158/421 (37%), Positives = 230/421 (54%), Gaps = 25/421 (5%)
Query: 80 CGVPDPSDG-LSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 92 CGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWE 151
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +AD+MI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 152 SATPLRFREVPYAYIREGHEKQADVMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 211
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H+ A+M+ FY + + L
Sbjct: 212 THFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLP 271
Query: 247 PDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAP---PDACEASFDAVST 303
DD RG+Q LYG + T + PQ + P +P P P+ C+ +FD V+
Sbjct: 272 DDDRRGIQQLYGSKSGSPTK----IPPQPRTTSRPSIPDKPKNPTYGPNICDGNFDTVAM 327
Query: 304 IRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYW 363
+RGE+F FK + WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++W
Sbjct: 328 LRGEMFVFKERWFWRVRKNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHW 387
Query: 364 VYDGEKPVLG-PAPLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS 420
V+D G P + EL GL + AAL W P K YFFRG Y+RF+ R V+S
Sbjct: 388 VFDEASLEPGYPKHIKELGRGLPTDRIDAALFWMP-SGKTYFFRGNKYYRFNEELRIVES 446
Query: 421 PVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFG 479
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ G
Sbjct: 447 EYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMG 506
Query: 480 C 480
C
Sbjct: 507 C 507
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 475 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 509
>ref|NP_005932.1| matrix metalloproteinase 16 (membrane-inserted) [Homo sapiens]
dbj|BAA23742.1| (AB009303) membrane-type matrix metalloproteinase 3 [Homo sapiens]
Length = 607
Score = 290 bits (735), Expect = 2e-77
Identities = 161/438 (36%), Positives = 230/438 (51%), Gaps = 33/438 (7%)
Query: 80 CGVPDPSDGLSARN-RQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + G S + R+KR+ L+G +W+ +TY I ++ + R+ + A VW
Sbjct: 101 CGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160
Query: 139 DVTPLTFTEV-----HEGR--ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDV 191
+VTPLTF EV G+ DI I FA +HGD PFDG GG LAHA+FP GD
Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220
Query: 192 HFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSP 247
HFD DE WT+G+ G DL VA HE GH LGL+H+ A+M+ FY + L
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
Query: 248 DDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIA--------------PLEPDAPP 291
DD +G+Q +YG P P T P + P I + P P A P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340
Query: 292 DACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQ 351
+ C+ +F+ ++ +R E+F FK + WR+R ++ GYP + W+GLP +DA +E++
Sbjct: 341 NICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSD 400
Query: 352 GHIWFFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHA--ALVWGPEKNKIYFFRGRDY 408
G+ FF+G +YWV+ G P L LG P H + +W + K YFF+G Y
Sbjct: 401 GNFVFFKGNKYWVFKDTTLQPGYPHDLITLG-SGIPPHGIDSAIWWEDVGKTYFFKGDRY 459
Query: 409 WRFHPSTRRVDSPVPRRATDWRGVPSEIDAAF-QDADGYAYFLRGRLYWKFDPVKVKALE 467
WR+ + +D P+ T W+G+P AF +G+ YF +G+ YWKF+ +K
Sbjct: 460 WRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEP 519
Query: 468 GFPRLVGPDFFGCAEPAN 485
G PR + DF GC P +
Sbjct: 520 GHPRSILKDFMGCDGPTD 537
>emb|CAB92315.1| (AJ010731) membrane-type-4 matrix metalloproteinase [Mus musculus]
Length = 578
Score = 286 bits (725), Expect = 3e-76
Identities = 176/435 (40%), Positives = 229/435 (52%), Gaps = 44/435 (10%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQ--LVQEQVRQTMAEALKVW 137
C +PD G A++R+KR +W K +L++R+ FP L ++ VR M ALKVW
Sbjct: 109 CSLPDLPPG--AQSRRKRQTPPPTKWSKRNLSWRVRTFPRDSPLGRDTVRALMYYALKVW 166
Query: 138 SDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHR-EGDVHFDYD 196
SD+TPL F EV ADI IDF++ H D PFDGPGG +AHAFFP H GD HFD D
Sbjct: 167 SDITPLNFHEVAGNAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGDHHTAGDTHFDDD 226
Query: 197 ETWTI--GDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFY------TFRYPLSLSPD 248
E WT D G DL VA HEFGH +GL H A ++M +Y RY L +
Sbjct: 227 EPWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAPSSIMQPYYQGPVGDPLRY--GLPYE 284
Query: 249 DCRGVQHLYGQPWPTVTSRTPALGPQAGIDT--NEIAPLEPDAP------------PDAC 294
D V LYG ++ P A +DT E PL P+ P P C
Sbjct: 285 DRVRVWQLYGV--------RESVSPTAQLDTPEPEEPPLLPEPPNNRSSTPPQKDVPHRC 336
Query: 295 EASFDAVSTIRGELFFFKAGFVWRL-RGGQLQPGYPALASRHWQGLP---SPVDAAFEDA 350
A FDAV+ IRGE FFFK + WRL R L PA R W+GLP VDA +E
Sbjct: 337 TAHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERT 396
Query: 351 QGH-IWFFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDY 408
H I FF+G +YWV+ G P P+++ L + A W ++ YFF+ + Y
Sbjct: 397 SDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAVFSWA-HNDRTYFFKDQLY 455
Query: 409 WRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEG 468
WR+ TRR+D P + WRGVPS +D A + +DG +YF RG+ YWK +++A G
Sbjct: 456 WRYDDHTRRMDPGYPAQGPLWRGVPSMLDDAMRWSDGASYFFRGQEYWKVLDGELEAAPG 515
Query: 469 FPRLVGPDFFGCAEP 483
+P+ D+ C EP
Sbjct: 516 YPQSTARDWLVCGEP 530
>ref|NP_035976.1| matrix metalloproteinase 17; membrane type-4 matrix
metalloproteinase [Mus musculus]
dbj|BAA82708.1| (AB021224) membrane-type-4 matrix metalloproteinase [Mus musculus]
Length = 587
Score = 286 bits (724), Expect = 4e-76
Identities = 176/435 (40%), Positives = 229/435 (52%), Gaps = 44/435 (10%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQ--LVQEQVRQTMAEALKVW 137
C +PD G A++R+KR +W K +L++R+ FP L ++ VR M ALKVW
Sbjct: 109 CSLPDLPPG--AQSRRKRQTPPPTKWSKRNLSWRVRTFPRDSPLGRDTVRALMYYALKVW 166
Query: 138 SDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHR-EGDVHFDYD 196
SD+TPL F EV ADI IDF++ H D PFDGPGG +AHAFFP H GD HFD D
Sbjct: 167 SDITPLNFHEVAGNAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGDHHTAGDTHFDDD 226
Query: 197 ETWTI--GDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFY------TFRYPLSLSPD 248
E WT D G DL VA HEFGH +GL H A ++M +Y RY L +
Sbjct: 227 EPWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAPSSIMQPYYQGPVGDPVRY--GLPYE 284
Query: 249 DCRGVQHLYGQPWPTVTSRTPALGPQAGIDT--NEIAPLEPDAP------------PDAC 294
D V LYG ++ P A +DT E PL P+ P P C
Sbjct: 285 DRVRVWQLYGV--------RESVSPTAQLDTPEPEEPPLLPEPPNNRSSTPPQKDVPHRC 336
Query: 295 EASFDAVSTIRGELFFFKAGFVWRL-RGGQLQPGYPALASRHWQGLP---SPVDAAFEDA 350
A FDAV+ IRGE FFFK + WRL R L PA R W+GLP VDA +E
Sbjct: 337 TAHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERT 396
Query: 351 QGH-IWFFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDY 408
H I FF+G +YWV+ G P P+++ L + A W ++ YFF+ + Y
Sbjct: 397 SDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAVFSWA-HNDRTYFFKDQLY 455
Query: 409 WRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEG 468
WR+ TRR+D P + WRGVPS +D A + +DG +YF RG+ YWK +++A G
Sbjct: 456 WRYDDHTRRMDPGYPAQGPLWRGVPSMLDDAMRWSDGASYFFRGQEYWKVLDGELEAAPG 515
Query: 469 FPRLVGPDFFGCAEP 483
+P+ D+ C EP
Sbjct: 516 YPQSTARDWLVCGEP 530
>ref|NP_032634.1| matrix metalloproteinase 14 (membrane-inserted); Membrane type
1-MMP [Mus musculus]
emb|CAA58520.2| (X83536) MT-MMP [Mus musculus]
Length = 582
Score = 284 bits (719), Expect = 2e-75
Identities = 158/421 (37%), Positives = 227/421 (53%), Gaps = 25/421 (5%)
Query: 80 CGVPDP-SDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 93 CGVPDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWE 152
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI FA +HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H+ +MS FY + + L
Sbjct: 213 THFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSDIMSPFYQWMDTENFVLP 272
Query: 247 PDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAP---PDACEASFDAVST 303
DD RG+Q LYG + T + PQ + P +P P P+ C+ +FD V+
Sbjct: 273 DDDRRGIQQLYGSKSGSPTK----MPPQPRTTSRPSVPDKPKNPAYGPNICDGNFDTVAM 328
Query: 304 IRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYW 363
+RGE+F FK ++WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++W
Sbjct: 329 LRGEMFVFKERWLWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGTFVFFKGDKHW 388
Query: 364 VYDGEKPVLGPA-PLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS 420
V G A + EL GL + AL W P K YFFRG Y+RF+ R VDS
Sbjct: 389 VCVEASLEPGYANHIKELVRGLPSDKIDTALFWMP-NGKTYFFRGNKYYRFNEEFRAVDS 447
Query: 421 PVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFG 479
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ G
Sbjct: 448 EYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMG 507
Query: 480 C 480
C
Sbjct: 508 C 508
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 476 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 510
>dbj|BAA13071.1| (D86331) matrix metalloproteinase, MT2MMP [Homo sapiens]
Length = 564
Score = 284 bits (719), Expect = 2e-75
Identities = 163/451 (36%), Positives = 223/451 (49%), Gaps = 48/451 (10%)
Query: 80 CGVPDPSD---GLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKV 136
CGVPD + R R+KR+ L+G +W LT+ I + +L + + A +V
Sbjct: 6 CGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRV 65
Query: 137 WSDVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHRE 188
W TPL F EV + ADIM+ FA +HGD PFDG GG LAHA+FP
Sbjct: 66 WEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLG 125
Query: 189 GDVHFDYDETWTIG--DDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LS 244
GD HFD DE WT D G +L VA HE GH LGL+H++ A+M+ FY ++
Sbjct: 126 GDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFK 185
Query: 245 LSPDDCRGVQHLYG---------QPWPTVTSRTPALG--------------------PQA 275
L DD RG+Q LYG QP PTVT R P P+
Sbjct: 186 LPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKP 245
Query: 276 GIDTNEIAPLEPDA-PPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASR 334
G A PD P+ C+ FD V+ +RGE+F FK + WR+R ++ YP
Sbjct: 246 GPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGH 305
Query: 335 HWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGL-VRFPVHAALV 392
W+GLP + AA+E G FF+G +YW++ G P PLT GL + + +
Sbjct: 306 FWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAI 365
Query: 393 WGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDAD-GYAYFLR 451
W +FF+ YWRF+ T+R D P+ + W+G+P+ AF D Y YF +
Sbjct: 366 WWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYK 425
Query: 452 GRLYWKFDPVKVKALEGFPRLVGPDFFGCAE 482
G YWKFD +++ G+P+ + DF GC E
Sbjct: 426 GTKYWKFDNERLRMEPGYPKSILRDFMGCQE 456
>ref|NP_002419.1| matrix metalloproteinase 15 (membrane-inserted); Matrix
metalloproteinase 15 [Homo sapiens]
sp|P51511|COGU_HUMAN MATRIX METALLOPROTEINASE-15 PRECURSOR (MMP-15) (MEMBRANE-TYPE
MATRIX METALLOPROTEINASE 2) (MT-MMP 2) (MTMMP2)
pir||I38029 matrix metalloproteinase 15 (EC 3.4.24.-) membrane type precursor -
human
emb|CAA88373.1| (Z48482) membrane-type matrix metalloproteinase 2 [Homo sapiens]
Length = 669
Score = 284 bits (719), Expect = 2e-75
Identities = 163/451 (36%), Positives = 223/451 (49%), Gaps = 48/451 (10%)
Query: 80 CGVPDPSD---GLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKV 136
CGVPD + R R+KR+ L+G +W LT+ I + +L + + A +V
Sbjct: 111 CGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRV 170
Query: 137 WSDVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHRE 188
W TPL F EV + ADIM+ FA +HGD PFDG GG LAHA+FP
Sbjct: 171 WEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLG 230
Query: 189 GDVHFDYDETWTIG--DDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LS 244
GD HFD DE WT D G +L VA HE GH LGL+H++ A+M+ FY ++
Sbjct: 231 GDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFK 290
Query: 245 LSPDDCRGVQHLYG---------QPWPTVTSRTPALG--------------------PQA 275
L DD RG+Q LYG QP PTVT R P P+
Sbjct: 291 LPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKP 350
Query: 276 GIDTNEIAPLEPDA-PPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASR 334
G A PD P+ C+ FD V+ +RGE+F FK + WR+R ++ YP
Sbjct: 351 GPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGH 410
Query: 335 HWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGL-VRFPVHAALV 392
W+GLP + AA+E G FF+G +YW++ G P PLT GL + + +
Sbjct: 411 FWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAI 470
Query: 393 WGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDAD-GYAYFLR 451
W +FF+ YWRF+ T+R D P+ + W+G+P+ AF D Y YF +
Sbjct: 471 WWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYK 530
Query: 452 GRLYWKFDPVKVKALEGFPRLVGPDFFGCAE 482
G YWKFD +++ G+P+ + DF GC E
Sbjct: 531 GTKYWKFDNERLRMEPGYPKSILRDFMGCQE 561
>sp|P53690|COGT_MOUSE MATRIX METALLOPROTEINASE-14 PRECURSOR (MMP-14) (MEMBRANE-TYPE
MATRIX METALLOPROTEINASE 1) (MT-MMP 1) (MTMMP1)
pir||I48673 matrix metalloproteinase (EC 3.4.24.-) membrane type precursor -
mouse
Length = 582
Score = 281 bits (711), Expect = 1e-74
Identities = 157/421 (37%), Positives = 225/421 (53%), Gaps = 25/421 (5%)
Query: 80 CGVPDP-SDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + A R+KR+ + G +W+ ++T+ I + ++ + + + +A +VW
Sbjct: 93 CGVPDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATFEAIRKAFRVWE 152
Query: 139 DVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGD 190
TPL F EV HE +ADIMI F HGD PFDG GG LAHA+FP + GD
Sbjct: 153 SATPLRFREVPYAYIREGHEKQADIMILFPEGLHGDSTPFDGEGGFLAHAYFPGPNIGGD 212
Query: 191 VHFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LS 246
HFD E WT+ ++ G D+ VA HE GH LGL+H+ +MS FY + + L
Sbjct: 213 THFDSAEPWTVQNEDLNGNDIFLVAVHELGHALGLEHSNDPSDIMSPFYQWMDTENFVLP 272
Query: 247 PDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAP---PDACEASFDAVST 303
DD RG+Q LYG + T + PQ + P +P P P+ C+ +FD V+
Sbjct: 273 DDDRRGIQQLYGSKSGSPTK----MPPQPRTTSRPSVPDKPKNPAYGPNICDGNFDTVAM 328
Query: 304 IRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYW 363
+RGE+F FK ++WR+R Q+ GYP + W+GLP+ ++ A+E G FF+G ++W
Sbjct: 329 LRGEMFVFKERWLWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGTFVFFKGDKHW 388
Query: 364 VYDGEKPVLGPA-PLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDS 420
V G A + EL GL + AL W P K YFFRG Y+RF+ R VDS
Sbjct: 389 VCVEASLEPGYANHIKELVRGLPSDKIDTALFWMP-NGKTYFFRGNKYYRFNEEFRAVDS 447
Query: 421 PVPRRATDWRGVPSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFG 479
P+ W G+P +F +D + YF +G YWKF+ K+K G+P+ D+ G
Sbjct: 448 EYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMG 507
Query: 480 C 480
C
Sbjct: 508 C 508
Score = 33.6 bits (75), Expect = 5.1
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)
Query: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341
+F+K W+ +L +PGYP A R W G PS
Sbjct: 476 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 510
>gb|AAF61270.1|AF244994_1 (AF244994) membrane type-3 matrix metalloproteinase [Scyliorhinus
torazame]
Length = 613
Score = 279 bits (705), Expect = 7e-74
Identities = 156/434 (35%), Positives = 227/434 (51%), Gaps = 33/434 (7%)
Query: 80 CGVPDP-SDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + R+KR+ L+G +W +TY I F ++ + + + + A VW
Sbjct: 105 CGVPDQFGSSIRFSVRRKRYALTGQKWHHKHITYSIKNFTPKVGKLETHRAIRRAFDVWQ 164
Query: 139 DVTPLTFTEV-------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDV 191
+VTPLTF E+ + DI I FA +HGD PFDG GG LAHA+FP GD
Sbjct: 165 NVTPLTFEEIPYVELENKKRDVDITIMFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 224
Query: 192 HFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSP 247
HFD DE WT+G+ G DL VAAHE GH LGL+H+ A+M+ FY + L
Sbjct: 225 HFDSDEPWTLGNPNHDGNDLFLVAAHELGHALGLEHSNDPSAIMAPFYQYMDTENFQLPQ 284
Query: 248 DDCRGVQHLYG---------QPWPTVTS---------RTPALGPQAGIDTNEIAPLEPDA 289
DD +G+Q +YG +P PTV R P+ P+ P P A
Sbjct: 285 DDLQGIQKIYGPPDKIAHPTKPLPTVPPHRFNPPSDPRKPSRQPRPPRPPTRDKPSFPGA 344
Query: 290 PPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFED 349
P+ C+ +F+ ++ +RGE+F FK + WR+R ++ GYP + W+GLPS ++
Sbjct: 345 KPNICDGNFNTLAILRGEMFVFKDHWFWRVRNNRVLDGYPMQIAYFWRGLPSKHLSSLGT 404
Query: 350 AQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGL-VRFPVHAALVWGPEKNKIYFFRGRD 407
A G F +G++YWV+ LG P + ELG V + VW + K YFF+G
Sbjct: 405 ADGKFVFLKGSKYWVFKEATLELGYPQNVVELGSGVPSQGIDSAVWWEDVGKTYFFKGDR 464
Query: 408 YWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDAD-GYAYFLRGRLYWKFDPVKVKAL 466
YWR++ T V S P+ + W+G+P AF + GY +F +G+ YWKF+ K++
Sbjct: 465 YWRYNEETHVVGSGYPKSISIWKGIPKSPQGAFVSKESGYTFFYKGKEYWKFNNHKLRVE 524
Query: 467 EGFPRLVGPDFFGC 480
+PR + ++ GC
Sbjct: 525 PSYPRSILKEWMGC 538
>ref|NP_004132.1| matrix metalloproteinase 17 (membrane-inserted); membrane-type-4
matrix metalloproteinase [Homo sapiens]
emb|CAA61753.1| (X89576) MT4-MMP [Homo sapiens]
Length = 519
Score = 277 bits (701), Expect = 2e-73
Identities = 170/423 (40%), Positives = 221/423 (52%), Gaps = 27/423 (6%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQ--LVQEQVRQTMAEALKVW 137
C +PD AR R++ + +W K +L++R+ FP L + VR M ALKVW
Sbjct: 26 CSLPDLPVLTQARRRRQ--APAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVW 83
Query: 138 SDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFP-KTHREGDVHFDYD 196
SD+ PL F EV ADI IDF++ H D PFDGPGG +AHAFFP H GD HFD D
Sbjct: 84 SDIAPLNFHEVAGSTADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDD 143
Query: 197 ETWTI--GDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFY------TFRYPLSLSPD 248
E WT D G DL VA HEFGH +GL H AA ++M +Y RY L +
Sbjct: 144 EAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRY--GLPYE 201
Query: 249 DCRGVQHLYG---QPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIR 305
D V LYG PT P L P+ D AP D P C FDAV+ IR
Sbjct: 202 DKVRVWQLYGVRESVSPTAQPEEPPLLPEPP-DNRSSAPPRKDV-PHRCSTHFDAVAQIR 259
Query: 306 GELFFFKAGFVWRL-RGGQLQPGYPALASRHWQGLP---SPVDAAFEDAQGH-IWFFQGA 360
GE FFFK + WRL R L PA R W+GLP VDA +E H I FF+G
Sbjct: 260 GEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGD 319
Query: 361 QYWVYDGEKPVLG-PAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVD 419
+YWV+ G P P+++ L + AA W ++ YFF+ + YWR+ TR +D
Sbjct: 320 RYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWA-HNDRTYFFKDQLYWRYDDHTRHMD 378
Query: 420 SPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFG 479
P ++ WRGVPS +D A + +DG +YF RG+ YWK +++ G+P+ D+
Sbjct: 379 PGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLV 438
Query: 480 CAE 482
C +
Sbjct: 439 CGD 441
>gb|AAF47255.1| (AE003464) CG4859 gene product [Drosophila melanogaster]
Length = 568
Score = 273 bits (691), Expect = 3e-72
Identities = 166/421 (39%), Positives = 223/421 (52%), Gaps = 27/421 (6%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGV D + +R KR+ L G RW +LTY+I ++P +L + V + A VWS+
Sbjct: 77 CGVRDRVG--TGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSE 134
Query: 140 VTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 199
T LTFT G I I F HGD FDG GG LAHAFFP GD HFD E W
Sbjct: 135 DTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFPVF--GGDAHFDDAELW 192
Query: 200 TIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYT-FRYPLSLSPDDCRGVQHLYG 258
TIG +GT+L QVAAHEFGH LGL H+ + ALM+ FY F L DD +Q LYG
Sbjct: 193 TIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYG 252
Query: 259 QPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPP---DAC-EASFDAV-STIRGELFFFKA 313
+ +T L P P P P C ++ D + ++ +GE + FK
Sbjct: 253 R-------KTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFKG 305
Query: 314 GFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDG-EKPVL 372
++L ++ GYP L S+ W GLP +DAAF G +FF+G QYW Y G + +
Sbjct: 306 DKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKTYFFKGTQYWRYQGRQMDGV 365
Query: 373 GPAPLTELGLVRFPVH--AALVWGPEKNKIYFFRGRDYWRFHPSTR-RVDSPVPRRATDW 429
P ++E G P H AA+VWG KIYFF+G +WRF P+ R V + P+ ++W
Sbjct: 366 YPKEISE-GFTGIPDHLDAAMVWG-GNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNW 423
Query: 430 RGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKV---KALEGFPRLVGPDFFGCAE-PAN 485
GVP+ +DAA + +GY YF +G Y++F + A FPR +FGC P++
Sbjct: 424 EGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATPPFPRPTAHWWFGCKNTPSS 483
Query: 486 T 486
T
Sbjct: 484 T 484
>ref|NP_032635.1| matrix metalloproteinase 15; Membrane type 2-MMP [Mus musculus]
dbj|BAA23667.1| (D86332) membrane type-2 matrix metalloproteinase [Mus musculus]
Length = 657
Score = 273 bits (691), Expect = 3e-72
Identities = 159/451 (35%), Positives = 218/451 (48%), Gaps = 48/451 (10%)
Query: 80 CGVPDPSD---GLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKV 136
CGVPD + R R+KR+ L+G W LT+ I + +L + + A +V
Sbjct: 107 CGVPDQFGVHVKANLRRRRKRYTLTGKAWNNYHLTFSIQNYTEKLGWYNSMEAVRRAFQV 166
Query: 137 WSDVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHRE 188
W VTPL F EV ADIM+ FA +HGD PFDG GG LAHA+FP
Sbjct: 167 WEQVTPLVFQEVSYDDIRLRRRAEADIMVLFASGFHGDSSPFDGVGGFLAHAYFPGPGLG 226
Query: 189 GDVHFDYDETWTIG--DDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LS 244
GD HFD DE WT D G L VA HE GH LGL+H++ A+M+ FY +
Sbjct: 227 GDTHFDADEPWTFSSTDLHGISLFLVAVHELGHALGLEHSSNPSAIMAPFYQWMDTDNFQ 286
Query: 245 LSPDDCRGVQHLYG---------QPWPTVTSRTPALG--------------------PQA 275
L DD RG+Q LYG +P PTV R P P+
Sbjct: 287 LPEDDLRGIQQLYGSPDGKPQPTRPLPTVRPRRPGRPDHQPPRPPQPPHPGGKPERPPKP 346
Query: 276 GIDTNEIAPLEPDA-PPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASR 334
G A PD P+ C+ +FD V+ +RGE+F FK + WR+R ++ YP
Sbjct: 347 GPPPQPRATERPDQYGPNICDGNFDTVAVLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGH 406
Query: 335 HWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGL-VRFPVHAALV 392
W+GLP + AA+E GH FF+G +YW++ G P PL+ G + + +
Sbjct: 407 FWRGLPGNISAAYERQDGHFVFFKGNRYWLFREANLEPGYPQPLSSYGTDIPYDRIDTAI 466
Query: 393 WGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDAD-GYAYFLR 451
W +FF+ YWRF+ T+ D P+ + W+G+P+ AF D Y YF +
Sbjct: 467 WWEPTGHTFFFQADRYWRFNEETQHGDPGYPKPISVWQGIPTSPKGAFLSNDAAYTYFYK 526
Query: 452 GRLYWKFDPVKVKALEGFPRLVGPDFFGCAE 482
G YWKF+ +++ G P+ + DF GC E
Sbjct: 527 GTKYWKFNNERLRMEPGHPKSILRDFMGCQE 557
>gb|AAB07491.1| (U66463) membrane type-matrix metalloproteinase [Gallus gallus]
Length = 608
Score = 268 bits (679), Expect = 8e-71
Identities = 154/440 (35%), Positives = 225/440 (51%), Gaps = 36/440 (8%)
Query: 80 CGVPDPSDGLSARN-RQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWS 138
CGVPD + G S N R+KR+ L+G +W+ + Y I ++ + R+ + A VW
Sbjct: 101 CGVPDQTRGSSKFNIRRKRYALTGQKWQHKHIAYSIKNVTPKVGDAETRKAIRRAFDVWQ 160
Query: 139 DVTPLTFTEV-----HEGR--ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDV 191
+VTPLTF EV G+ DI I FA +HGD PFDG GG LAHA+FP GD
Sbjct: 161 NVTPLTFEEVPYIELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220
Query: 192 HFDYDETWTIGDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP--LSLSP 247
HFD DE WT+G+ G DL VA HE GH LGL+H+ A+M+ FY + L
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280
Query: 248 DDCRGVQHLYGQP--WPTVTSRTPALGPQAGIDTNEIA----------------PLEPDA 289
DD +G+Q +YG P P T P + P I + P P A
Sbjct: 281 DDLQGIQKIYGPPDRIPPPTRPLPTVPPHRSIPPADPRKNDRQPKPPRPPTGDKPSYPGA 340
Query: 290 PPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFED 349
P+ C+ +F+ + +R E+F FK + WR+R ++ GYP + W+GLP +DA +E+
Sbjct: 341 KPNICDGNFNTLVILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYEN 400
Query: 350 AQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVHA--ALVWGPEKNKIYFFRGR 406
++G+ FF+ ++WV+ G P L LG P H + +W + K YFF+G
Sbjct: 401 SEGNFVFFKSNKFWVFKDTTLQPGYPHDLITLG-SGIPSHGIDSAIWWEDVGKTYFFKGD 459
Query: 407 DYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAF-QDADGYAYFLRGRLYWKFDPVKVKA 465
YWR+ R +D P+ T W+G+P AF +G+ YF++ + + ++
Sbjct: 460 RYWRYGEEMRSMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFIKEKSTGNSTKM-LRV 518
Query: 466 LEGFPRLVGPDFFGCAEPAN 485
G+PR + DF GC P +
Sbjct: 519 EPGYPRSILKDFMGCDGPTD 538
>dbj|BAA22225.1| (D85510) SMCP-2 [Homo sapiens]
Length = 507
Score = 259 bits (656), Expect = 4e-68
Identities = 147/395 (37%), Positives = 197/395 (49%), Gaps = 45/395 (11%)
Query: 133 ALKVWSDVTPLTFTEV--------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPK 184
A +VW TPL F EV + ADIM+ FA +HGD PFDG GG LAHA+FP
Sbjct: 5 AFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPG 64
Query: 185 THREGDVHFDYDETWTIG--DDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYP 242
GD HFD DE WT D G +L VA HE GH LGL+H++ A+M+ FY ++
Sbjct: 65 PGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDV 124
Query: 243 --LSLSPDDCRGVQHLYG---------QPWPTVTSRTPALG------------------- 272
L DD RG+Q LYG QP PTVT R P
Sbjct: 125 DNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPER 184
Query: 273 -PQAGIDTNEIAPLEPDA-PPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPA 330
P+ G A PD P+ C+ FD V+ +RGE+F FK + WR+R ++ YP
Sbjct: 185 PPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPM 244
Query: 331 LASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGL-VRFPVH 388
W+GLP + AA+E G FF+G +YW++ G P PLT GL + +
Sbjct: 245 PIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRI 304
Query: 389 AALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDAD-GYA 447
+W +FF+ YWRF+ T+R D P+ + W+G+P+ AF D Y
Sbjct: 305 DTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYT 364
Query: 448 YFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAE 482
YF +G YWKFD +++ G+P+ + DF GC E
Sbjct: 365 YFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQE 399
>ref|NP_057239.1| matrix metalloproteinase 17 (membrane-inserted); membrane-type-4
matrix metalloproteinase [Homo sapiens]
dbj|BAA82707.1| (AB021225) membrane-type-4 matrix metalloproteinase [Homo sapiens]
Length = 605
Score = 254 bits (642), Expect = 2e-66
Identities = 164/423 (38%), Positives = 215/423 (50%), Gaps = 28/423 (6%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQ--LVQEQVRQTMAEALKVW 137
C +PD AR R++ + +W K +L++R+ FP L + VR M ALKVW
Sbjct: 113 CSLPDLPVLTQARRRRQ--APAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVW 170
Query: 138 SDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHRE-GDVHFDYD 196
SD+ PL F EV ADI IDF++ H D PFD AHAFFP H G HF+ D
Sbjct: 171 SDIAPLNFHEVAGSTADIQIDFSKADHNDGYPFDARRH-RAHAFFPGHHHTAGYTHFNDD 229
Query: 197 ETWTI--GDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYT------FRYPLSLSPD 248
E WT D G DL VA HEFGH +GL H AA ++M +Y RY L +
Sbjct: 230 EAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPY--E 287
Query: 249 DCRGVQHLYG---QPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIR 305
D V LYG PT P L P+ D AP D P C FDAV+ IR
Sbjct: 288 DKVRVWQLYGVRESVSPTAQPEEPPLLPEPP-DNRSSAPPRKDVP-HRCSTHFDAVAQIR 345
Query: 306 GELFFFKAGFVWRL-RGGQLQPGYPALASRHWQGLP---SPVDAAFEDAQGH-IWFFQGA 360
GE FFFK + WRL R L PA R W+GLP VDA +E H I FF+G
Sbjct: 346 GEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGD 405
Query: 361 QYWVYDGEKPVLG-PAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVD 419
+YWV+ G P P+++ L + AA W ++ YFF+ + YWR+ TR +D
Sbjct: 406 RYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWA-HNDRTYFFKDQLYWRYDDHTRHMD 464
Query: 420 SPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFG 479
P ++ WRGVPS +D A + +DG +YF RG+ YWK +++ G+P+ D+
Sbjct: 465 PGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLV 524
Query: 480 CAE 482
C +
Sbjct: 525 CGD 527
>sp|Q28397|COG3_HORSE STROMELYSIN-1 PRECURSOR (MATRIX METALLOPROTEINASE-3) (MMP-3)
gb|AAB05774.1| (U62529) matrix metalloproteinase 3 [Equus caballus]
Length = 477
Score = 254 bits (641), Expect = 2e-66
Identities = 158/392 (40%), Positives = 216/392 (54%), Gaps = 34/392 (8%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGVPD + K W KT LTYRI+ + L ++ V + +ALK+W +
Sbjct: 92 CGVPDVGHFTTFPGMPK--------WSKTHLTYRIVNYTQDLPRDAVDSDVEKALKIWEE 143
Query: 140 VTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 199
VTPLTF+ ++EG ADIMI FA HGD PFDGPG +LAHA+ P GD HFD DE W
Sbjct: 144 VTPLTFSRIYEGEADIMITFAVREHGDFFPFDGPGKVLAHAYPPGPGMNGDAHFDDDEHW 203
Query: 200 TIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFY-TFRYP--LSLSPDDCRGVQHL 256
T D G + L VAAHE GH LGL H+T +ALM Y T + P + LS DD G+Q L
Sbjct: 204 T-KDASGINFLLVAAHELGHSLGLYHSTNTEALMYPLYNTLKGPARVRLSQDDVTGIQSL 262
Query: 257 YGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEA-SFDAVSTIRGELFFFKAGF 315
YG P PA P + ++ +E P P A SFDA+ST+RGE+ FFK +
Sbjct: 263 YGPP--------PA-SPDSPVEPSEPEPPAPGTLAMCDPALSFDAISTLRGEILFFKDRY 313
Query: 316 VWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDGEKPVLG- 373
WR L P + ++S W LPS +DAA+E ++ ++ F+G ++W G + G
Sbjct: 314 FWRKTFRTLVPEFHPISS-FWPSLPSGIDAAYEVTSRDSVFIFKGNKFWAIRGNEEQAGY 372
Query: 374 PAPLTELGLVRFPVHA----ALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR-ATD 428
P + LG FP A ++ EK K YFF YWRF + ++ P++ A D
Sbjct: 373 PRGIHTLG---FPPTVRKIDAAIFDKEKQKTYFFVEDKYWRFDEKRQSMEPGYPKQIAED 429
Query: 429 WRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460
+ G+ S++DAAF ++ G+ YF G ++FDP
Sbjct: 430 FPGIDSKLDAAF-ESFGFFYFFSGSSQFEFDP 460
>sp|P28862|COG3_MOUSE STROMELYSIN-1 PRECURSOR (MATRIX METALLOPROTEINASE-3) (MMP-3)
(TRANSIN-1) (SL-1)
pir||KCMSS1 stromelysin 1 (EC 3.4.24.17) precursor - mouse
emb|CAA47029.1| (X66402) stromelysin-i [Mus musculus]
Length = 477
Score = 253 bits (639), Expect = 4e-66
Identities = 161/390 (41%), Positives = 209/390 (53%), Gaps = 30/390 (7%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGVPD G S +W K+ +TYRI+ + L ++ V + +ALKVW +
Sbjct: 92 CGVPDVG-GFST-------FPGSPKWRKSHITYRIVNYTPDLPRQSVDSAIEKALKVWEE 143
Query: 140 VTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 199
VTPLTF+ + EG ADIMI FA HGD +PFDGPG +LAHA+ P GD HFD DE W
Sbjct: 144 VTPLTFSRISEGEADIMISFAVGEHGDFVPFDGPGTVLAHAYAPGPGINGDAHFDDDERW 203
Query: 200 TIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS---LSPDDCRGVQHL 256
T D GT+L VAAHE GH LGL H+ A+ALM Y LS LS DD G+Q L
Sbjct: 204 T-EDVTGTNLFLVAAHELGHSLGLYHSAKAEALMYPVYKSSTDLSRFHLSQDDVDGIQSL 262
Query: 257 YGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEAS--FDAVSTIRGELFFFKAG 314
YG TP P + + LEP+ P C ++ FDAVST+RGE+ FFK
Sbjct: 263 YG---------TPTASPDVLVVPTKSNSLEPETSP-MCSSTLFFDAVSTLRGEVLFFKDR 312
Query: 315 FVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDGEKPVLG 373
WR +P + L S W LPS +DAA+E + ++ F+G Q+W G + + G
Sbjct: 313 HFWRKSLRTPEPEF-YLISSFWPSLPSNMDAAYEVTNRDTVFIFKGNQFWAIRGHEELAG 371
Query: 374 -PAPLTELGL-VRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR-ATDWR 430
P + LGL A + EK K YFF YWRF + ++ PR+ A D+
Sbjct: 372 YPKSIHTLGLPATVKKIDAAISNKEKRKTYFFVEDKYWRFDEKKQSMEPGFPRKIAEDFP 431
Query: 431 GVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460
GV S +DA F +A G+ YF G +FDP
Sbjct: 432 GVDSRVDAVF-EAFGFLYFFSGSSQLEFDP 460
>ref|NP_034939.1| matrix metalloproteinase 3; progelatinase; stromelysin 1 [Mus
musculus]
emb|CAA44860.1| (X63162) transin-1 [Mus musculus]
Length = 479
Score = 253 bits (639), Expect = 4e-66
Identities = 161/390 (41%), Positives = 209/390 (53%), Gaps = 30/390 (7%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGVPD G S +W K+ +TYRI+ + L ++ V + +ALKVW +
Sbjct: 94 CGVPDVG-GFST-------FPGSPKWRKSHITYRIVNYTPDLPRQSVDSAIEKALKVWEE 145
Query: 140 VTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 199
VTPLTF+ + EG ADIMI FA HGD +PFDGPG +LAHA+ P GD HFD DE W
Sbjct: 146 VTPLTFSRISEGEADIMISFAVGEHGDFVPFDGPGTVLAHAYAPGPGINGDAHFDDDERW 205
Query: 200 TIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS---LSPDDCRGVQHL 256
T D GT+L VAAHE GH LGL H+ A+ALM Y LS LS DD G+Q L
Sbjct: 206 T-EDVTGTNLFLVAAHELGHSLGLYHSAKAEALMYPVYKSSTDLSRFHLSQDDVDGIQSL 264
Query: 257 YGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEAS--FDAVSTIRGELFFFKAG 314
YG TP P + + LEP+ P C ++ FDAVST+RGE+ FFK
Sbjct: 265 YG---------TPTASPDVLVVPTKSNSLEPETSP-MCSSTLFFDAVSTLRGEVLFFKDR 314
Query: 315 FVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDGEKPVLG 373
WR +P + L S W LPS +DAA+E + ++ F+G Q+W G + + G
Sbjct: 315 HFWRKSLRTPEPEF-YLISSFWPSLPSNMDAAYEVTNRDTVFIFKGNQFWAIRGHEELAG 373
Query: 374 -PAPLTELGL-VRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR-ATDWR 430
P + LGL A + EK K YFF YWRF + ++ PR+ A D+
Sbjct: 374 YPKSIHTLGLPATVKKIDAAISNKEKRKTYFFVEDKYWRFDEKKQSMEPGFPRKIAEDFP 433
Query: 431 GVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460
GV S +DA F +A G+ YF G +FDP
Sbjct: 434 GVDSRVDAVF-EAFGFLYFFSGSSQLEFDP 462
>gb|AAA36321.1| (J03209) matrix metalloproteinase-3 [Homo sapiens]
gb|AAA00036.1| prostromelysin=matrix metalloproteinase [human, Peptide, 477 aa]
gb|AAB36942.1| (U78045) stromelysin [Homo sapiens]
Length = 477
Score = 252 bits (637), Expect = 6e-66
Identities = 162/392 (41%), Positives = 209/392 (52%), Gaps = 34/392 (8%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGVPD + K W KT LTYRI+ + L ++ V + +ALKVW +
Sbjct: 92 CGVPDVGHFRTFPGIPK--------WRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEE 143
Query: 140 VTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 199
VTPLTF+ ++EG ADIMI FA HGD PFDGPG +LAHA+ P GD HFD DE W
Sbjct: 144 VTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQW 203
Query: 200 TIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS---LSPDDCRGVQHL 256
T D GT+L VAAHE GH LGL H+ +ALM Y L+ LS DD G+Q L
Sbjct: 204 T-KDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSL 262
Query: 257 YGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEA-SFDAVSTIRGELFFFKAGF 315
YG P + P+ + E P EP P + A SFDAVST+RGE+ FK
Sbjct: 263 YGPPPDS---------PETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRH 313
Query: 316 VWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDGEKPVLG- 373
WR +L+P L S W LPS VDAA+E ++ ++ F+G Q+W G + G
Sbjct: 314 FWRKSLRKLEPEL-HLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGY 372
Query: 374 PAPLTELGLVRFPVHA----ALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR-ATD 428
P + LG FP A + EKNK YFF YWRF ++ P++ A D
Sbjct: 373 PRGIHTLG---FPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAED 429
Query: 429 WRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460
+ G+ S+IDA F++ G+ YF G +FDP
Sbjct: 430 FPGIDSKIDAVFEEF-GFFYFFTGSSQLEFDP 460
>ref|NP_002413.1| matrix metalloproteinase 3 (stromelysin 1, progelatinase) [Homo
sapiens]
sp|P08254|COG3_HUMAN STROMELYSIN-1 PRECURSOR (MATRIX METALLOPROTEINASE-3) (MMP-3)
(TRANSIN-1) (SL-1)
pir||KCHUS1 stromelysin 1 (EC 3.4.24.17) precursor - human
emb|CAA28859.1| (X05232) preprostromelysin [Homo sapiens]
Length = 477
Score = 252 bits (637), Expect = 6e-66
Identities = 162/392 (41%), Positives = 209/392 (52%), Gaps = 34/392 (8%)
Query: 80 CGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSD 139
CGVPD + K W KT LTYRI+ + L ++ V + +ALKVW +
Sbjct: 92 CGVPDVGHFRTFPGIPK--------WRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEE 143
Query: 140 VTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETW 199
VTPLTF+ ++EG ADIMI FA HGD PFDGPG +LAHA+ P GD HFD DE W
Sbjct: 144 VTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQW 203
Query: 200 TIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS---LSPDDCRGVQHL 256
T D GT+L VAAHE GH LGL H+ +ALM Y L+ LS DD G+Q L
Sbjct: 204 T-KDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSL 262
Query: 257 YGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEA-SFDAVSTIRGELFFFKAGF 315
YG P + P+ + E P EP P + A SFDAVST+RGE+ FK
Sbjct: 263 YGPPPDS---------PETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRH 313
Query: 316 VWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDGEKPVLG- 373
WR +L+P L S W LPS VDAA+E ++ ++ F+G Q+W G + G
Sbjct: 314 FWRKSLRKLEPEL-HLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGY 372
Query: 374 PAPLTELGLVRFPVHA----ALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR-ATD 428
P + LG FP A + EKNK YFF YWRF ++ P++ A D
Sbjct: 373 PRGIHTLG---FPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAED 429
Query: 429 WRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460
+ G+ S+IDA F++ G+ YF G +FDP
Sbjct: 430 FPGIDSKIDAVFEEF-GFFYFFTGSSQLEFDP 460
Database: nr
Number of letters in database: 182,691,300
Number of sequences in database: 580,189
Lambda K H
0.323 0.142 0.473
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 178760004
Number of Sequences: 580189
Number of extensions: 8180867
Number of successful extensions: 16100
Number of sequences better than 10.0: 331
Number of HSP's better than 10.0 without gapping: 272
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 13782
Number of HSP's gapped (non-prelim): 627
length of query: 488
length of database: 182,691,300
effective HSP length: 48
effective length of query: 440
effective length of database: 154,842,228
effective search space: 68130580320
effective search space used: 68130580320
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.9 bits)
S2: 73 (32.8 bits)
