Score E
Sequences producing significant alignments: (bits) Value
ref|NP_055601.1| KIAA0337 gene product [Homo sapiens] >gi|2... 2535 0.0
gb|AAF55465.1| (AE003719) CG7397 gene product [Drosophila m... 347 5e-94
pir||T16657 hypothetical protein R02F2.3 - Caenorhabditis e... 156 1e-36
ref|NP_055444.1| KIAA0294 gene product [Homo sapiens] >gi|2... 147 7e-34
dbj|BAB13452.1| (AB046846) KIAA1626 protein [Homo sapiens] 141 4e-32
dbj|BAB12119.1| (AB047595) hypothetical protein [Macaca fas... 141 4e-32
pir||T03307 hypothetical protein AAB71662.1 - human (fragme... 140 9e-32
dbj|BAB16676.1| (AB043125) JNK/SAPK-associated protein 1d [... 128 5e-28
dbj|BAB16675.1| (AB043124) JNK/SAPK-associated protein 1c [... 128 5e-28
dbj|BAB16674.1| (AB043123) JNK/SAPK-associated protein 1b [... 128 5e-28
ref|NP_038959.1| mitogen activated protein kinase 8 interac... 128 5e-28
gb|AAF26842.1|AF178636_1 (AF178636) JNK interacting protein... 128 5e-28
dbj|BAA85874.1| (AB005662) JNK/SAPK-associated protein-1 [M... 128 5e-28
gb|AAF50505.1| (AE003557) CG8110 gene product [Drosophila m... 127 9e-28
dbj|BAA83018.1| (AB028989) KIAA1066 protein [Homo sapiens] 127 1e-27
dbj|BAA25442.1| (AB011088) KIAA0516 protein [Homo sapiens] 122 2e-26
sp|P34609|YO60_CAEEL HYPOTHETICAL 128.6 KD PROTEIN ZK1098.1... 116 1e-24
gb|AAB69637.1| (U82517) GrfA [Dictyostelium discoideum] 111 8e-23
ref|NP_067585.1| breakpoint cluster region, isoform 2 [Homo... 108 5e-22
gb|AAB60390.1| (U07000) breakpoint cluster region protein [... 108 7e-22
gb|AAB60389.1| (U07000) breakpoint cluster region protein [... 108 7e-22
ref|XP_000840.1| breakpoint cluster region [Homo sapiens] >... 108 7e-22
gb|AAA65939.1| (M24603) bcr [Homo sapiens] 106 2e-21
ref|NP_004318.2| breakpoint cluster region, isoform 1 [Homo... 106 2e-21
gb|AAF48732.1| (AE003505) CG8557 gene product [Drosophila m... 106 3e-21
ref|NP_031926.1| ect2 oncogene [Mus musculus] >gi|6015052|s... 96 3e-18
dbj|BAB14498.1| (AK023267) unnamed protein product [Homo sa... 96 4e-18
gb|AAD47903.1|AF090533_1 (AF090533) unconventional myosin h... 94 1e-17
gb|AAF50508.1| (AE003557) pbl gene product [Drosophila mela... 92 4e-17
gb|AAD52845.1|AF136492_1 (AF136492) Pebble [Drosophila mela... 92 4e-17
pir||T18289 racGAP protein - slime mold (Dictyostelium disc... 91 9e-17
gb|AAA35594.1| (M15025) BCR-ABL protein [Homo sapiens] 91 9e-17
pir||B47485 ABR protein 2 - human 90 2e-16
sp|Q12979|ABR_HUMAN ACTIVE BREAKPOINT CLUSTER REGION-RELATE... 90 2e-16
ref|NP_001083.1| active BCR-related gene [Homo sapiens] >gi... 90 2e-16
dbj|BAA92229.1| (AK000004) FLJ00004 protein [Homo sapiens] 89 5e-16
ref|NP_056574.1| faciogenital dysplasia homolog 3 [Mus musc... 87 1e-15
ref|NP_032027.1| faciogenital dysplasia homolog [Mus muscul... 87 1e-15
ref|NP_004454.1| faciogenital dysplasia protein [Homo sapie... 86 2e-15
gb|AAC27698.1| (AF038388) actin-filament binding protein Fr... 85 4e-15
pir||TVHUA2 bcr (breakpoint cluster region) protein, splice... 85 7e-15
dbj|BAA92600.1| (AB037783) KIAA1362 protein [Homo sapiens] 84 1e-14
gb|AAF50584.1| (AE003559) CG8606 gene product [Drosophila m... 83 2e-14
gb|AAC35432.1| (AF017370) faciogenital dysplasia protein [D... 83 2e-14
gb|AAD29952.1|AF114487_1 (AF114487) intersectin long isofor... 81 8e-14
gb|AAF45386.1| (AE002567) EG:23E12.2 gene product [Drosophi... 80 1e-13
emb|CAA21413.1| (AL031884) /prediction=(method:""genefinder... 80 1e-13
ref|NP_003015.1| intersectin 1 (SH3 domain protein); inters... 80 1e-13
ref|NP_034717.1| intersectin (SH3 domain protein 1A); inter... 80 2e-13
dbj|BAA92653.1| (AB037836) KIAA1415 protein [Homo sapiens] 78 7e-13
>ref|NP_055601.1| KIAA0337 gene product [Homo sapiens]
dbj|BAA20795.1| (AB002335) KIAA0337 [Homo sapiens]
Length = 1510
Score = 2535 bits (6499), Expect = 0.0
Identities = 1276/1510 (84%), Positives = 1276/1510 (84%)
Query: 1 MARRLPRTXXXXXXXXXXXXTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQXXXX 60
MARRLPRT TGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQ
Sbjct: 1 MARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGS 60
Query: 61 XXXXXXXXWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS 120
WAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS
Sbjct: 61 DAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS 120
Query: 121 SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPXXXXXXXXXXXXXXXAYRS 180
SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPP AYRS
Sbjct: 121 SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSEFSNGEAGEAYRS 180
Query: 181 LSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES 240
LSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES
Sbjct: 181 LSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES 240
Query: 241 KGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRXXXXXXXXXXXXXXXIREV 300
KGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRR IREV
Sbjct: 241 KGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV 300
Query: 301 EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERXXXXXXXXXXXXHRNFHLDPKLADIL 360
EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSER HRNFHLDPKLADIL
Sbjct: 301 EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADIL 360
Query: 361 SPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE 420
SPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE
Sbjct: 361 SPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPE 420
Query: 421 PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLXXX 480
PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCL
Sbjct: 421 PPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA 480
Query: 481 XXXXXXXXXXXXXXXXXXXXXXSKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM 540
SKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM
Sbjct: 481 APPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYM 540
Query: 541 QPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXXXXXXVRHCMQTWHAQQKVGALLVQSFS 600
QPLKQPENSVLCDPSLVDEIFDQIP VRHCMQTWHAQQKVGALLVQSFS
Sbjct: 541 QPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFS 600
Query: 601 KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRI 660
KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRI
Sbjct: 601 KDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRI 660
Query: 661 PRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEA 720
PRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEA
Sbjct: 661 PRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEA 720
Query: 721 HIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTXXXXXXXXXXXXXX 780
HIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTT
Sbjct: 721 HIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMS 780
Query: 781 XYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKL 840
YTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKL
Sbjct: 781 LYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKL 840
Query: 841 SESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEF 900
SESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEF
Sbjct: 841 SESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEF 900
Query: 901 PHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPS 960
PHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPS
Sbjct: 901 PHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPS 960
Query: 961 PEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHXXXXXXXXX 1020
PEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCH
Sbjct: 961 PEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLRS 1020
Query: 1021 XXXXXXXXXXXXXXXXXXXXXXXXXXXXPGPQPCLHISIAGSGLEMTPGLGEGDPRPELV 1080
PGPQPCLHISIAGSGLEMTPGLGEGDPRPELV
Sbjct: 1021 PPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPELV 1080
Query: 1081 PFXXXXXXXXXXXXXGTLQXXXXXXXXXXXFGNXXXXXXXXXXXXXXXXXXXXXXXXXXX 1140
PF GTLQ FGN
Sbjct: 1081 PFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLPL 1140
Query: 1141 XXXXXXXXXCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVY 1200
CGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVY
Sbjct: 1141 SGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVY 1200
Query: 1201 QSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVT 1260
QSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVT
Sbjct: 1201 QSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVT 1260
Query: 1261 LGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGV 1320
LGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGV
Sbjct: 1261 LGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGV 1320
Query: 1321 WVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEEL 1380
WVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEEL
Sbjct: 1321 WVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEEL 1380
Query: 1381 LWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCXXXX 1440
LWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLC
Sbjct: 1381 LWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPP 1440
Query: 1441 XXXXXXXEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLXXXXXXXXETVGRDD 1500
EKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRL ETVGRDD
Sbjct: 1441 PPPDTGPEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSSGGGSSSETVGRDD 1500
Query: 1501 STNHLLLWRV 1510
STNHLLLWRV
Sbjct: 1501 STNHLLLWRV 1510
>gb|AAF55465.1| (AE003719) CG7397 gene product [Drosophila melanogaster]
Length = 1101
Score = 347 bits (881), Expect = 5e-94
Identities = 197/496 (39%), Positives = 291/496 (57%), Gaps = 14/496 (2%)
Query: 512 DMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXXXXX 571
D R +V + EQSYVESL+T++ Y++ LK PE++ + D VDEIF +P
Sbjct: 153 DTRTYVVQEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIH 212
Query: 572 XXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPA 631
++ + W QQKVG + +FSK ++ +Y+++++N AK+A+R K RP+
Sbjct: 213 EKFLSDLKSRLDDWDVQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPS 272
Query: 632 FLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNI 691
F KFLE + RE+K K L +L+IKPVQ+ P YELL + L+KHT DHPD L + + +
Sbjct: 273 FSKFLETTAREHKGKLTLDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVLKLV 332
Query: 692 KQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKK 751
+ IN R E + L+E+E IEG+ DL AP R+FL ++V G +K
Sbjct: 333 HDILVHINCKEREIMENGQREATLRELEGVIEGITDLIAPERQFLLFDLVSMPSGQGARK 392
Query: 752 DRSLFLFTDLIVCTTXXXXXXXXXXXXXXXY--TAASVIDTASKYKMLWKLPLEDADIIK 809
DR FLF DL+V T+ T A+ +DT +KYK L K+ L+ +I+K
Sbjct: 393 DRGFFLFNDLLVLTSIKKRSGTIRKPNSSICPGTVATTLDT-NKYKFLTKISLDCLEIVK 451
Query: 810 GASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEK 869
S+ N + I I L ED L Q++ ++ ++ +PHQ L+D +R+L + R LSE+
Sbjct: 452 --SKDENIKRIVSEIETLAEDCNKLQQITDITVTIKYPHQYLEDVIRELHREVQRQLSER 509
Query: 870 QALCYALSFPPTKLELCATRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASS-KSCLD 928
Q L+ LEL + P G F + R +E++F+EAK+KLA++ +
Sbjct: 510 QTNDTQLNM----LELTVSSPNGNQKLAVVFSKTEKRTQWEESFNEAKQKLAATLERHPI 565
Query: 929 PEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEA 988
PEFL +IPI KTR+G+QF+CAA TL+ + +VWVCNSDGYVGQVC++SL EP+V +
Sbjct: 566 PEFLTSIPIRKTRAGLQFTCAAATLSD----NRDVWVCNSDGYVGQVCIMSLHPEPNVTS 621
Query: 989 CIAVCSARILCIGAVP 1004
C VC+ARILC+ +VP
Sbjct: 622 CNGVCNARILCVASVP 637
Score = 276 bits (698), Expect = 1e-72
Identities = 138/332 (41%), Positives = 207/332 (61%), Gaps = 11/332 (3%)
Query: 1182 EAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELV 1241
E+ QS++W+GTEDGC+HVY S+D+IR ++N +K++H ++V ILYL+N+VFVSLANG++
Sbjct: 778 ESNQSTMWIGTEDGCIHVYNSTDNIRIKKNRIKIEHHSAVYSILYLDNRVFVSLANGDIC 837
Query: 1242 VYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFY 1301
VY R+ W+ + +++GT SP+ K+++V GRLWC Q + VL +TL + +
Sbjct: 838 VYLRDGATSWNTCSSHCLSIGTVTSPVNKLLNVNGRLWCSIQGIIKVLDVETLTVVNQIQ 897
Query: 1302 VGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAII 1361
+ D S+ + M S+ VW++++ SAH+ +H +T + + EV++ P V++ML+ D II
Sbjct: 898 ISSD-SKPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNKMLSNCDEII 956
Query: 1362 RQHKAACLRITALLVCEELLWVGTSAGVVLTMPT---SPGTVSCPRAPLSPTGLGQGHTG 1418
RQHKAACLR+T+LL C++L+W+GTSAGV+LT+P G ++ + PTG+ GHTG
Sbjct: 957 RQHKAACLRVTSLLCCKDLIWIGTSAGVLLTIPAQGYEKGAIN-----IVPTGIPHGHTG 1011
Query: 1419 HVRFLAAVQLPDGFNLLCXXXXXXXXXXXEKLPSLEHRDSPWHRGPAPARPKMLVISGGD 1478
HVRFL V+ G + S H L+ISGGD
Sbjct: 1012 HVRFLTFVE-TTGLEGAASGAGGGRDAGSSNSDEYTKQGSIKHSKSKSETNNTLIISGGD 1070
Query: 1479 GYEDFRLXXXXXXXXETVGRDDSTNHLLLWRV 1510
GYEDFR E GR+DSTNHLL+W++
Sbjct: 1071 GYEDFR-NSGANSLSEIAGREDSTNHLLIWQI 1101
>pir||T16657 hypothetical protein R02F2.3 - Caenorhabditis elegans
gb|AAA50717.1| (U00055) similar to guanine-nucleotide releasing factors including
BCR [Caenorhabditis elegans]
Length = 620
Score = 156 bits (391), Expect = 1e-36
Identities = 85/226 (37%), Positives = 133/226 (58%), Gaps = 4/226 (1%)
Query: 503 SKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFD 562
S+ + +R A LLDTE+S+VE L L+ YM+PL+QP L + SLVD+IF
Sbjct: 341 SRASLRRHYSVRHLAARELLDTEKSFVEGLEFLVTKYMRPLRQPLECTLIEASLVDKIFY 400
Query: 563 QIPXXXXXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAV 622
+IP + + WH +G +L+ FSK ++ Y +++DNF AK ++
Sbjct: 401 RIPEILAHHQVLLTTLSQRIDQWHKDAILGDVLLAHFSKQSMIETYISFVDNFKFAKASI 460
Query: 623 RVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHP 682
A++ + AF K+ + R++ K L L+I P+QR+PRYEL+VK +LKHTP +H D
Sbjct: 461 IQARQ-KHAFEKYYNRCCRDHPNKLDLDSLLISPIQRVPRYELIVKQMLKHTPVEHEDRE 519
Query: 683 LLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDL 728
LL AQR+I +A IN+ +E+ E+ L+EIEA ++G++D+
Sbjct: 520 RLLRAQRHIHCLAVAINQHKDGSEQMEQR---LREIEAIVDGLDDV 562
>ref|NP_055444.1| KIAA0294 gene product [Homo sapiens]
dbj|BAA20754.1| (AB002292) KIAA0294 [Homo sapiens]
Length = 1121
Score = 147 bits (368), Expect = 7e-34
Identities = 131/565 (23%), Positives = 264/565 (46%), Gaps = 83/565 (14%)
Query: 507 SKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPX 566
S+ QV +R+++ +++D+E++YV++L+ +++ Y +PL + E VL + L +F ++
Sbjct: 168 SQQQV-VRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKL-KTVFYRVKE 225
Query: 567 XXXXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAK 626
+ + W + + +G + V SFSK ++++ YS Y++NF A ++
Sbjct: 226 ILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTC 285
Query: 627 EARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLE 686
+PAFL+FL+Q + ++ L LM+KP+QR P++ LL++D+LK+T + HPD L
Sbjct: 286 ATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQM 345
Query: 687 AQRNIKQVAERINKGVRSAEEAERHARVLQEI-EAHIEGMEDLQAPLRRFLRQEMVIEV- 744
A ++ +AE++N+ R A++ ++ + I E ++ + L + R +R + +IE
Sbjct: 346 ALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKL--LSSGSRYLIRSDDMIETV 403
Query: 745 ----KAIGGKKDRSLFLFTDLIVCTTXXXXXXXXXXXXXXXYTAASVIDTASKYKMLWKL 800
I K+R +F+ D+++C T S + ++ +Y + W +
Sbjct: 404 YNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHD-----------SRVMSSQRYLLKWSV 452
Query: 801 PLEDADIIKGASQATNREN-----------------------------IQKAISRLDEDL 831
PL D I+ S A E+ + + + L DL
Sbjct: 453 PLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDL 512
Query: 832 TTLGQMSKLSESLGFPHQSLDDAL-RDLSAAMHRDLSEKQALCYALSFPPTKLELCATRP 890
+GQ+++L +L +Q+L+ ++ D ++ + R + +K+ A +L+L +
Sbjct: 513 NVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPGKQD 572
Query: 891 E-GTDSY---IFEFPHPDARLGFEQAFDEAKRKLASSKS----CLD-----------PEF 931
+ G ++ +F P + + + AK L C++ P
Sbjct: 573 KSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCVEDDGNHIKKEKHPLL 632
Query: 932 LKAIPIMKTR-SGMQFSCAA----PTLNSCPEPSP------EVWVCNSDGYVGQVCLLSL 980
+ +P+M + + CAA P LN+ +P +W+ + +GQ+ ++S
Sbjct: 633 VGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWIGSCTHQMGQIAIVSF 692
Query: 981 R-AEPDVEACIAVCSARILCIGAVP 1004
+ + P V C V +RILC+ VP
Sbjct: 693 QNSTPKVIECFNV-ESRILCMLYVP 716
Score = 107 bits (265), Expect = 9e-22
Identities = 66/248 (26%), Positives = 117/248 (46%), Gaps = 33/248 (13%)
Query: 1187 SVWLGTEDGCVHVYQSSDSIRDRRNSMKLQH-----AASVTCILYLNNQVFVSLANGELV 1241
++ +GTE+G + +Y+SS + ++LQH ++V + + ++ L NG +
Sbjct: 742 TICVGTEEGSISIYKSSQGSK----KVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVA 797
Query: 1242 VYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFY 1301
Y R WD + K + LG P+ ++ + LW +V ++S +T +E
Sbjct: 798 SYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLE 855
Query: 1302 VGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAII 1361
Q+ ++ M S +G+W+ + + L+H +T + L ++++ PVH ML G
Sbjct: 856 AHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQR-- 913
Query: 1362 RQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQG------ 1415
L +T+LLVC LL VGTS GV++ +P PR P G+G
Sbjct: 914 -------LSVTSLLVCHGLLMVGTSLGVLVALPV-------PRLQGIPKVTGRGMVSYHA 959
Query: 1416 HTGHVRFL 1423
H V+F+
Sbjct: 960 HNSPVKFI 967
>dbj|BAB13452.1| (AB046846) KIAA1626 protein [Homo sapiens]
Length = 1284
Score = 141 bits (353), Expect = 4e-32
Identities = 131/570 (22%), Positives = 245/570 (42%), Gaps = 81/570 (14%)
Query: 509 PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXX 568
PQ +R+H+ +++ +E SYVESL+ ++Q Y PL + E L +F ++
Sbjct: 317 PQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKAL-SARKCQVVFFRVKEIL 375
Query: 569 XXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ + W + +K+G L V SFSK +++++YS Y++NF +A ++ A
Sbjct: 376 HCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLT 435
Query: 629 RPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQ 688
+PAFL+FL++ + ++ L LM+KP+QR P++ LL++D+LK+TP HPD L A
Sbjct: 436 KPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLAL 495
Query: 689 RNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIE--VKA 746
++ +AE++N+ R A++ +Q++ + L L RQ ++ E +
Sbjct: 496 TELETLAEKLNEQKRLADQVAE----IQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTET 551
Query: 747 IGG-------KKDRSLFLFTDLIVCTTXXXXXXXXXXXXXXXYTAASVIDTASKYKMLWK 799
+ G K+R +FL D++VC +S++ KY + W
Sbjct: 552 VYGDRGQLIKSKERRVFLLNDMLVCAN----INFKPANHRGQLEISSLVPLGPKYVVKWN 607
Query: 800 LPLEDADIIK------------------------GASQATNR-----ENIQKAISRLDED 830
L +++ + QA N+ + + + L +D
Sbjct: 608 TALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKD 667
Query: 831 LTTLGQMSKLSESLGFPHQSLD-DALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATR 889
L + Q++ L +L +Q+L+ +D A+ R + K+ ++ + +L L +
Sbjct: 668 LAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRL-LLPGK 726
Query: 890 PEGTD-----SYIFEFPHPDARLGFEQAFDEAKRKLASSKS----CLD-----------P 929
P+ + +F P+P +++ + AK L C D P
Sbjct: 727 PDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCP 786
Query: 930 EFLKAIPIMKTRS-GMQFSCAAPTLNSCP----------EPSPEVWV-CNSDGYVGQVCL 977
IP +R+ +Q + +CP P +WV +G GQV +
Sbjct: 787 ILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEI 846
Query: 978 LSLRAEPDVEACIAVCSARILCIGAVPGLQ 1007
SL +A +LC+ +P L+
Sbjct: 847 FSLNRPSPRTVKSFPLAAPVLCMEYIPELE 876
Score = 111 bits (274), Expect = 8e-23
Identities = 78/251 (31%), Positives = 118/251 (46%), Gaps = 21/251 (8%)
Query: 1180 DPEA-YQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANG 1238
DP A ++ LG +DG + +Y S D+ S + V C+ + + L +G
Sbjct: 890 DPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDG 949
Query: 1239 ELVVYQREAGH-FWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLE 1297
L Y R +G WD ++ V L P+ ++S+ +W C RV VL TLQ +
Sbjct: 950 TLAAYPRTSGGVLWDLES-PPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQ 1008
Query: 1298 HMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGS 1357
F QD + V MV + GVW+ + L+H +T E L E+++ +L G
Sbjct: 1009 QSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPG- 1067
Query: 1358 DAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLG---- 1413
++H L +T+LL+C+ LLWVGT GV++ +P P P+ TG G
Sbjct: 1068 ----QKH----LCVTSLLICQGLLWVGTDQGVIVLLPV-PRLEGIPKI----TGKGMVSL 1114
Query: 1414 QGHTGHVRFLA 1424
GH G V FLA
Sbjct: 1115 NGHCGPVAFLA 1125
>dbj|BAB12119.1| (AB047595) hypothetical protein [Macaca fascicularis]
Length = 567
Score = 141 bits (353), Expect = 4e-32
Identities = 93/362 (25%), Positives = 170/362 (46%), Gaps = 20/362 (5%)
Query: 509 PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXX 568
PQ +R+H+ +++ +E SYVESL+ ++Q Y PL + E L +F ++
Sbjct: 66 PQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKAL-SARKCQAVFFRVKEIL 124
Query: 569 XXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ + W + +K+G L V SFSK +++++YS Y++NF +A ++ A
Sbjct: 125 HCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLT 184
Query: 629 RPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQ 688
+PAFL+FL++ + ++ L LM+KP+QR P++ LL++D+LK+TP HPD L A
Sbjct: 185 KPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLAL 244
Query: 689 RNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIE--VKA 746
++ +AE++N+ R A++ +Q++ + L L RQ ++ E +
Sbjct: 245 TELETLAEKLNEQKRLADQVAE----IQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTET 300
Query: 747 IGG-------KKDRSLFLFTDLIVCTTXXXXXXXXXXXXXXXYTAASVIDTASKYKMLWK 799
+ G K+R +FL D++VC +S++ KY + W
Sbjct: 301 VYGDRGQLIKSKERRVFLLNDMLVCAN----INFKPANHRGQLEISSLVPLGPKYVVKWN 356
Query: 800 LPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPH--QSLDDALRD 857
L +++ + I + ++ LG P Q L D +D
Sbjct: 357 TALPQVQVVEVGQDGGTYDKDNVLIQHAGAKKASTSGQAQNKVYLGPPRLFQELQDLQKD 416
Query: 858 LS 859
L+
Sbjct: 417 LA 418
>pir||T03307 hypothetical protein AAB71662.1 - human (fragment)
gb|AAB71662.1| (AF009205) unknown [Homo sapiens]
Length = 988
Score = 140 bits (350), Expect = 9e-32
Identities = 94/361 (26%), Positives = 185/361 (51%), Gaps = 23/361 (6%)
Query: 507 SKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPX 566
S+ QV +R+++ +++D+E++YV++L+ +++ Y +PL + E VL + L +F ++
Sbjct: 64 SQQQV-VRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKL-KTVFYRVKE 121
Query: 567 XXXXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAK 626
+ + W + + +G + V SFSK ++++ YS Y++NF A ++
Sbjct: 122 ILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTC 181
Query: 627 EARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLE 686
+PAFL+FL+Q + ++ L LM+KP QR P++ LL++D+LK+T + HPD L
Sbjct: 182 ATKPAFLEFLKQEQEASPDRTTLYSLMMKPXQRFPQFILLLQDMLKNTSKGHPDRLPLQM 241
Query: 687 AQRNIKQVAERINKGVRSAEEAERHARVLQEI-EAHIEGMEDLQAPLRRFLRQEMVIEV- 744
A ++ +AE++N+ R A++ ++ + I E ++ + L + R +R + +IE
Sbjct: 242 ALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKL--LSSGSRYLIRSDDMIETV 299
Query: 745 ----KAIGGKKDRSLFLFTDLIVCTTXXXXXXXXXXXXXXXYTAASVIDTASKYKMLWKL 800
I K+R +F+ D+++C T S + ++ +Y + W +
Sbjct: 300 YNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHD-----------SRVMSSQRYLLKWSV 348
Query: 801 PLEDADIIKGASQATNRENIQKAISRLDEDLTTL--GQMSKLSESLGFPHQSLDDALRDL 858
PL D I+ S A E+ + E L + + +K+ G +Q L + L DL
Sbjct: 349 PLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDL 408
Query: 859 S 859
+
Sbjct: 409 N 409
Score = 109 bits (270), Expect = 2e-22
Identities = 67/248 (27%), Positives = 117/248 (47%), Gaps = 33/248 (13%)
Query: 1187 SVWLGTEDGCVHVYQSSDSIRDRRNSMKLQH-----AASVTCILYLNNQVFVSLANGELV 1241
++ +GTE+G + +Y+SS + ++LQH +SV + + ++ L NG +
Sbjct: 609 TICVGTEEGSISIYKSSQGSK----KVRLQHFFTPEKSSVMSLACTSQSLYAGLVNGAVA 664
Query: 1242 VYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFY 1301
Y R WD + K + LG P+ ++ + LW +V ++S +T +E
Sbjct: 665 TYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLE 722
Query: 1302 VGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAII 1361
Q+ ++ M S +G+W+ + + L+H +T + L ++++ PVH ML G
Sbjct: 723 AHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQR-- 780
Query: 1362 RQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQG------ 1415
L +T+LLVC LL VGTS GV++ +P PR P G+G
Sbjct: 781 -------LSVTSLLVCHGLLMVGTSLGVLVALPV-------PRLQGIPKVTGRGMVSYHA 826
Query: 1416 HTGHVRFL 1423
H V+F+
Sbjct: 827 HNSPVKFI 834
>dbj|BAB16676.1| (AB043125) JNK/SAPK-associated protein 1d [Mus musculus]
Length = 1336
Score = 128 bits (318), Expect = 5e-28
Identities = 107/397 (26%), Positives = 174/397 (42%), Gaps = 60/397 (15%)
Query: 1164 SHGSFTRGSLEDL--LSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASV 1221
S+G+ + +E LS + ++WLG ++G ++V+ + + + +S+KL+ SV
Sbjct: 945 SNGTIVQPQVEPSGELSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKD--SV 1002
Query: 1222 TCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCG 1281
++++ +V V+LA+G L ++ R WD N+ + LG I M V R+WCG
Sbjct: 1003 LSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVNDRVWCG 1062
Query: 1282 CQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQL 1341
+N+V V+ P T+Q+E F V + GVWV+++ + + LYH T + L
Sbjct: 1063 YKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHL 1122
Query: 1342 AEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSP---- 1397
+VD+ P V +ML + + +RITALL+ LWVGT GVV+++P +
Sbjct: 1123 QDVDIEPYVSKMLGTG-----KLGFSFVRITALLIAGNRLWVGTGNGVVISIPLTETVVL 1177
Query: 1398 ------GTVSCPRAPLSPTGLGQGHTGHV-----------RFLAAVQLPDGFNLLCXXXX 1440
G + +P S G G HV F+ + LC
Sbjct: 1178 HRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSSDKAASSFIPYCSMAQA--QLCFHGH 1235
Query: 1441 XXXXXXXEKLP-------SLEHRDSPWHRGPAPARP----------KMLVISGGDGYEDF 1483
+P + DSP GP PA P LV+SGG+GY DF
Sbjct: 1236 RDAVKFFVSVPGNVLATLNGSVLDSP-SEGPGPAAPAADAEGQKLKNALVLSGGEGYIDF 1294
Query: 1484 RLXXXXXXXXETVGRD----------DSTNHLLLWRV 1510
R+ E D +H+++W+V
Sbjct: 1295 RIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQV 1331
>dbj|BAB16675.1| (AB043124) JNK/SAPK-associated protein 1c [Mus musculus]
Length = 1337
Score = 128 bits (318), Expect = 5e-28
Identities = 107/397 (26%), Positives = 174/397 (42%), Gaps = 60/397 (15%)
Query: 1164 SHGSFTRGSLEDL--LSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASV 1221
S+G+ + +E LS + ++WLG ++G ++V+ + + + +S+KL+ SV
Sbjct: 946 SNGTIVQPQVEPSGELSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKD--SV 1003
Query: 1222 TCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCG 1281
++++ +V V+LA+G L ++ R WD N+ + LG I M V R+WCG
Sbjct: 1004 LSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVNDRVWCG 1063
Query: 1282 CQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQL 1341
+N+V V+ P T+Q+E F V + GVWV+++ + + LYH T + L
Sbjct: 1064 YKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHL 1123
Query: 1342 AEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSP---- 1397
+VD+ P V +ML + + +RITALL+ LWVGT GVV+++P +
Sbjct: 1124 QDVDIEPYVSKMLGTG-----KLGFSFVRITALLIAGNRLWVGTGNGVVISIPLTETVVL 1178
Query: 1398 ------GTVSCPRAPLSPTGLGQGHTGHV-----------RFLAAVQLPDGFNLLCXXXX 1440
G + +P S G G HV F+ + LC
Sbjct: 1179 HRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSSDKAASSFIPYCSMAQA--QLCFHGH 1236
Query: 1441 XXXXXXXEKLP-------SLEHRDSPWHRGPAPARP----------KMLVISGGDGYEDF 1483
+P + DSP GP PA P LV+SGG+GY DF
Sbjct: 1237 RDAVKFFVSVPGNVLATLNGSVLDSP-SEGPGPAAPAADAEGQKLKNALVLSGGEGYIDF 1295
Query: 1484 RLXXXXXXXXETVGRD----------DSTNHLLLWRV 1510
R+ E D +H+++W+V
Sbjct: 1296 RIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQV 1332
>dbj|BAB16674.1| (AB043123) JNK/SAPK-associated protein 1b [Mus musculus]
Length = 1314
Score = 128 bits (318), Expect = 5e-28
Identities = 107/397 (26%), Positives = 174/397 (42%), Gaps = 60/397 (15%)
Query: 1164 SHGSFTRGSLEDL--LSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASV 1221
S+G+ + +E LS + ++WLG ++G ++V+ + + + +S+KL+ SV
Sbjct: 923 SNGTIVQPQVEPSGELSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKD--SV 980
Query: 1222 TCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCG 1281
++++ +V V+LA+G L ++ R WD N+ + LG I M V R+WCG
Sbjct: 981 LSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVNDRVWCG 1040
Query: 1282 CQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQL 1341
+N+V V+ P T+Q+E F V + GVWV+++ + + LYH T + L
Sbjct: 1041 YKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHL 1100
Query: 1342 AEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSP---- 1397
+VD+ P V +ML + + +RITALL+ LWVGT GVV+++P +
Sbjct: 1101 QDVDIEPYVSKMLGTG-----KLGFSFVRITALLIAGNRLWVGTGNGVVISIPLTETVVL 1155
Query: 1398 ------GTVSCPRAPLSPTGLGQGHTGHV-----------RFLAAVQLPDGFNLLCXXXX 1440
G + +P S G G HV F+ + LC
Sbjct: 1156 HRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSSDKAASSFIPYCSMAQA--QLCFHGH 1213
Query: 1441 XXXXXXXEKLP-------SLEHRDSPWHRGPAPARP----------KMLVISGGDGYEDF 1483
+P + DSP GP PA P LV+SGG+GY DF
Sbjct: 1214 RDAVKFFVSVPGNVLATLNGSVLDSP-SEGPGPAAPAADAEGQKLKNALVLSGGEGYIDF 1272
Query: 1484 RLXXXXXXXXETVGRD----------DSTNHLLLWRV 1510
R+ E D +H+++W+V
Sbjct: 1273 RIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQV 1309
>ref|NP_038959.1| mitogen activated protein kinase 8 interacting protein 3;
JNK-interacting protein 3 [Mus musculus]
gb|AAF26843.1|AF178637_1 (AF178637) JNK interacting protein-3b [Mus musculus]
Length = 1337
Score = 128 bits (318), Expect = 5e-28
Identities = 107/397 (26%), Positives = 174/397 (42%), Gaps = 60/397 (15%)
Query: 1164 SHGSFTRGSLEDL--LSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASV 1221
S+G+ + +E LS + ++WLG ++G ++V+ + + + +S+KL+ SV
Sbjct: 946 SNGTIVQPQVEPSGELSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKD--SV 1003
Query: 1222 TCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCG 1281
++++ +V V+LA+G L ++ R WD N+ + LG I M V R+WCG
Sbjct: 1004 LSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVNDRVWCG 1063
Query: 1282 CQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQL 1341
+N+V V+ P T+Q+E F V + GVWV+++ + + LYH T + L
Sbjct: 1064 YKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHL 1123
Query: 1342 AEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSP---- 1397
+VD+ P V +ML + + +RITALL+ LWVGT GVV+++P +
Sbjct: 1124 QDVDIEPYVSKMLGTG-----KLGFSFVRITALLIAGNRLWVGTGNGVVISIPLTETVVL 1178
Query: 1398 ------GTVSCPRAPLSPTGLGQGHTGHV-----------RFLAAVQLPDGFNLLCXXXX 1440
G + +P S G G HV F+ + LC
Sbjct: 1179 HRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSSDKAASSFIPYCSMAQA--QLCFHGH 1236
Query: 1441 XXXXXXXEKLP-------SLEHRDSPWHRGPAPARP----------KMLVISGGDGYEDF 1483
+P + DSP GP PA P LV+SGG+GY DF
Sbjct: 1237 RDAVKFFVSVPGNVLATLNGSVLDSP-SEGPGPAAPAADAEGQKLKNALVLSGGEGYIDF 1295
Query: 1484 RLXXXXXXXXETVGRD----------DSTNHLLLWRV 1510
R+ E D +H+++W+V
Sbjct: 1296 RIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQV 1332
>gb|AAF26842.1|AF178636_1 (AF178636) JNK interacting protein-3a [Mus musculus]
Length = 1322
Score = 128 bits (318), Expect = 5e-28
Identities = 107/397 (26%), Positives = 174/397 (42%), Gaps = 60/397 (15%)
Query: 1164 SHGSFTRGSLEDL--LSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASV 1221
S+G+ + +E LS + ++WLG ++G ++V+ + + + +S+KL+ SV
Sbjct: 931 SNGTIVQPQVEPSGELSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKD--SV 988
Query: 1222 TCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCG 1281
++++ +V V+LA+G L ++ R WD N+ + LG I M V R+WCG
Sbjct: 989 LSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVNDRVWCG 1048
Query: 1282 CQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQL 1341
+N+V V+ P T+Q+E F V + GVWV+++ + + LYH T + L
Sbjct: 1049 YKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHL 1108
Query: 1342 AEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSP---- 1397
+VD+ P V +ML + + +RITALL+ LWVGT GVV+++P +
Sbjct: 1109 QDVDIEPYVSKMLGTG-----KLGFSFVRITALLIAGNRLWVGTGNGVVISIPLTETVVL 1163
Query: 1398 ------GTVSCPRAPLSPTGLGQGHTGHV-----------RFLAAVQLPDGFNLLCXXXX 1440
G + +P S G G HV F+ + LC
Sbjct: 1164 HRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSSDKAASSFIPYCSMAQA--QLCFHGH 1221
Query: 1441 XXXXXXXEKLP-------SLEHRDSPWHRGPAPARP----------KMLVISGGDGYEDF 1483
+P + DSP GP PA P LV+SGG+GY DF
Sbjct: 1222 RDAVKFFVSVPGNVLATLNGSVLDSP-SEGPGPAAPAADAEGQKLKNALVLSGGEGYIDF 1280
Query: 1484 RLXXXXXXXXETVGRD----------DSTNHLLLWRV 1510
R+ E D +H+++W+V
Sbjct: 1281 RIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQV 1317
>dbj|BAA85874.1| (AB005662) JNK/SAPK-associated protein-1 [Mus musculus]
Length = 1305
Score = 128 bits (318), Expect = 5e-28
Identities = 107/397 (26%), Positives = 174/397 (42%), Gaps = 60/397 (15%)
Query: 1164 SHGSFTRGSLEDL--LSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASV 1221
S+G+ + +E LS + ++WLG ++G ++V+ + + + +S+KL+ SV
Sbjct: 914 SNGTIVQPQVEPSGELSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKD--SV 971
Query: 1222 TCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCG 1281
++++ +V V+LA+G L ++ R WD N+ + LG I M V R+WCG
Sbjct: 972 LSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVNDRVWCG 1031
Query: 1282 CQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQL 1341
+N+V V+ P T+Q+E F V + GVWV+++ + + LYH T + L
Sbjct: 1032 YKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHL 1091
Query: 1342 AEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSP---- 1397
+VD+ P V +ML + + +RITALL+ LWVGT GVV+++P +
Sbjct: 1092 QDVDIEPYVSKMLGTG-----KLGFSFVRITALLIAGNRLWVGTGNGVVISIPLTETVVL 1146
Query: 1398 ------GTVSCPRAPLSPTGLGQGHTGHV-----------RFLAAVQLPDGFNLLCXXXX 1440
G + +P S G G HV F+ + LC
Sbjct: 1147 HRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSSDKAASSFIPYCSMAQA--QLCFHGH 1204
Query: 1441 XXXXXXXEKLP-------SLEHRDSPWHRGPAPARP----------KMLVISGGDGYEDF 1483
+P + DSP GP PA P LV+SGG+GY DF
Sbjct: 1205 RDAVKFFVSVPGNVLATLNGSVLDSP-SEGPGPAAPAADAEGQKLKNALVLSGGEGYIDF 1263
Query: 1484 RLXXXXXXXXETVGRD----------DSTNHLLLWRV 1510
R+ E D +H+++W+V
Sbjct: 1264 RIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQV 1300
>gb|AAF50505.1| (AE003557) CG8110 gene product [Drosophila melanogaster]
Length = 1195
Score = 127 bits (316), Expect = 9e-28
Identities = 102/369 (27%), Positives = 168/369 (44%), Gaps = 52/369 (14%)
Query: 1163 SSHGSFTRGSLEDLLSV---DPEAYQS---SVWLGTEDGCVHVYQSSDSIRDRRNSMKLQ 1216
SS+ F SL +L D A S ++WLG +DG ++V+ S + + + L
Sbjct: 855 SSNLLFATKSLNPILETKDRDEPAMSSVGPTMWLGAQDGWLYVHSSVGRWHECLHRVLLP 914
Query: 1217 HAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGG 1276
A V I+++ +V V+LAN +L V++R+ WD ++ VTLG + I + G
Sbjct: 915 DA--VLAIVHVEARVVVALANAQLAVFRRQTDGQWDLNSYHLVTLGDRNHSIRCLCVAGE 972
Query: 1277 RLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPD 1336
R+W +N++ ++ P +L + H V M + GVWV+++ + + LY+
Sbjct: 973 RIWAAHRNKIFIVDPVSLNIVHSLDAHPRKESQVRQMAATGAGVWVSIRLDSTLRLYNTH 1032
Query: 1337 TFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMP-- 1394
TFE +VD+ P V +ML + + +RITAL+V LW+GTS GV++++P
Sbjct: 1033 TFEHKQDVDIEPYVSKMLGTG-----KLGFSFVRITALMVSCNRLWIGTSNGVIISVPLA 1087
Query: 1395 -TSPGTVSCP--RAPLSPTGLGQ----GHTGHVRFLAAVQLPDGFNLLCXXXXXXXXXXX 1447
P + S P + PL Q GH V+F +V
Sbjct: 1088 EVQPKSSSDPHGQMPLCCMANAQLSFHGHRDAVKFFVSV--------------------- 1126
Query: 1448 EKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLXXXXXXXX------ETVGRDDS 1501
P L+ + RP MLV+ GG+GY DFR+ +T+
Sbjct: 1127 ---PMLQQPNLNGGLTFTNKRPDMLVMCGGEGYIDFRINDNDMENSIQLEPNQTIENRGD 1183
Query: 1502 TNHLLLWRV 1510
++L++W V
Sbjct: 1184 KSYLIVWHV 1192
>dbj|BAA83018.1| (AB028989) KIAA1066 protein [Homo sapiens]
Length = 1069
Score = 127 bits (315), Expect = 1e-27
Identities = 109/385 (28%), Positives = 170/385 (43%), Gaps = 62/385 (16%)
Query: 1178 SVDPEAYQSS----VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFV 1233
S DP SS +WLG ++G ++V+ + + + +S+KL+ SV ++++ +V V
Sbjct: 690 SGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKD--SVLSLVHVKGRVLV 747
Query: 1234 SLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDT 1293
+LA+G L ++ R WD N+ + LG I M V R+WCG +N+V V+ P T
Sbjct: 748 ALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKT 807
Query: 1294 LQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRM 1353
+Q+E F V + GVWV+++ + + LYH T + L +VD+ P V +M
Sbjct: 808 MQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKM 867
Query: 1354 LAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSP----------GTVSCP 1403
L + + +RITALLV LWVGT GVV+++P + G +
Sbjct: 868 LGTG-----KLGFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANK 922
Query: 1404 RAPLSPTGLGQGHTGHV-----------RFLAAVQLPDGFNLLCXXXXXXXXXXXEKLP- 1451
+P S G G HV F+ + LC +P
Sbjct: 923 TSPTSGEGARPGGIIHVYGDDSSDRAASSFIPYCSMAQA--QLCFHGHRDAVKFFVSVPG 980
Query: 1452 ------SLEHRDSPWHRGPAPARP----------KMLVISGGDGYEDFRLXXXXXXXXET 1495
+ DSP GP PA P +LV+SGG+GY DFR+ E
Sbjct: 981 NVLATLNGSVLDSP-AEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEE 1039
Query: 1496 VGRDDS----------TNHLLLWRV 1510
D S +H+++W+V
Sbjct: 1040 GAGDMSQVKPVLSKAERSHIIVWQV 1064
>dbj|BAA25442.1| (AB011088) KIAA0516 protein [Homo sapiens]
Length = 653
Score = 122 bits (304), Expect = 2e-26
Identities = 104/393 (26%), Positives = 171/393 (43%), Gaps = 74/393 (18%)
Query: 1174 EDLLSVDPEAYQS---SVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQ 1230
+DL+ + + S ++WLG ++GC++V+ S R +S+KL+ S+ I+++
Sbjct: 274 QDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKD--SILSIVHVKGI 331
Query: 1231 VFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLS 1290
V V+LA+G L ++ R WD N+ + LG I M V ++WCG +N++ V+
Sbjct: 332 VLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQ 391
Query: 1291 PDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPV 1350
P +++E F V + GVWV+++ + + LYH T++ L +VD+ P V
Sbjct: 392 PKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYV 451
Query: 1351 HRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTS-------------- 1396
+ML + + +RITAL+V LWVGT GV++++P +
Sbjct: 452 SKMLGTG-----KLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETVILHQGRLLGLR 506
Query: 1397 -----------PGTV----------------SCPRAPLSPTGL-GQGHTGHVRFLAAVQL 1428
PG+V P ++ L GH V+F AV
Sbjct: 507 ANKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAV-- 564
Query: 1429 PDGFNLLCXXXXXXXXXXXEKLPSLEHRDSPWHRGPAPARP--KMLVISGGDGYEDFRLX 1486
G + +K P + P P MLVISGG+GY DFR+
Sbjct: 565 -PGQVISPQSSSSGTDLTGDKA-------GPSAQEPGSQTPLKSMLVISGGEGYIDFRM- 615
Query: 1487 XXXXXXXETVGRD---------DSTNHLLLWRV 1510
E +G D +HL++W+V
Sbjct: 616 GDEGGESELLGEDLPLEPSVTKAERSHLIVWQV 648
Score = 34.8 bits (78), Expect = 7.2
Identities = 16/53 (30%), Positives = 27/53 (50%)
Query: 953 LNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPG 1005
L + E S VW+C S +V ++ ++ VC++ +LCI +VPG
Sbjct: 67 LKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPG 119
>sp|P34609|YO60_CAEEL HYPOTHETICAL 128.6 KD PROTEIN ZK1098.10 IN CHROMOSOME III
pir||S40932 hypothetical protein ZK1098.10 - Caenorhabditis elegans
emb|CAA80140.1| (Z22176) strongly charged, weak similarity to tropomyosin and other
coiled coil proteins~cDNA EST yk21d1.5 comes from this
gene~cDNA EST yk29d6.3 comes from this gene~cDNA EST
yk29d6.5 comes from this gene~cDNA EST yk50d3.5 comes
from this gene~cDNA ES>
Length = 1139
Score = 116 bits (289), Expect = 1e-24
Identities = 92/348 (26%), Positives = 155/348 (44%), Gaps = 42/348 (12%)
Query: 1187 SVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQRE 1246
+VW+G ++ ++++ + + + +K+ A V I++ +++F +LANG + ++ R
Sbjct: 801 TVWMGGQNQYIYIHSAVTAWKQCLRRIKMPDA--VLSIVHYKSRIFAALANGTIAIFHRN 858
Query: 1247 AGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDS 1306
W + + S+ +G+ S + + V +W +N V+VL ++LQ+ +F
Sbjct: 859 KHGEWSDEGYHSLRVGSATSSVRSLCLVSTNIWATYKNCVVVLDAESLQIVKVFAAHPRK 918
Query: 1307 SRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKA 1366
V M GVW++++ + + LYH T+E L +VD+ P V +ML S +
Sbjct: 919 DSQVRNMQWVGAGVWLSIRLDSTLRLYHAHTYEHLQDVDIEPYVTKMLGTS-----KLDF 973
Query: 1367 ACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAV 1426
+ +R TALLV LW+GT GV++++P S S G G G VR A
Sbjct: 974 SYMRTTALLVSNRRLWIGTGTGVIISVPFSGQLEKKIETKDSKRPAGPG--GLVRVYGAT 1031
Query: 1427 --------QLPDGFNLLCXXXXXXXXXXXEKLPSLEHRDSPWHRGPAPARPK-------- 1470
+ D F C +L H+DS P K
Sbjct: 1032 SENATNDEKTNDDFIPYCNLAHA-------QLSFHGHKDSVKFFLGVPGASKNGEDESAE 1084
Query: 1471 -----MLVISGGDGYEDFRLXXXXXXXXETVG---RDDSTNHLLLWRV 1510
ML++SGGDGY DFR+ E G R +HL++W V
Sbjct: 1085 VTLRRMLIMSGGDGYIDFRI--GEENEPELTGQSIRPRDMSHLIIWEV 1130
>gb|AAB69637.1| (U82517) GrfA [Dictyostelium discoideum]
Length = 479
Score = 111 bits (274), Expect = 8e-23
Identities = 69/259 (26%), Positives = 131/259 (49%), Gaps = 9/259 (3%)
Query: 514 RKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIFDQIPXXXXXX 571
R H+ ++ E +YV++L +++ ++ PL Q S L P + +IF I
Sbjct: 146 RTHIVQEIMQVEVNYVKNLTLMVRKFLHPLAQLSTSKRPLLTPDRITQIFSTIENIQNHN 205
Query: 572 XXXXXXVRHCMQTWHAQQKVGALLVQSFSKDV--LVNIYSAYIDNFLNAKDAVRVAKEAR 629
+ ++ W A K L++ + + + YS YI+N+ + K+
Sbjct: 206 SIFSDGLTSRIKRWLADNKKDHLIIGDIFQKIGGFMQDYSKYINNYNQSIKTYNETKKTN 265
Query: 630 PAFLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQ 688
F +F+++ + + + L +L+I PVQ++PRY +L++DL+++T +DHPD+ L EA
Sbjct: 266 LPFAQFIKKVESDPELNDRELENLLITPVQQLPRYIMLIQDLIRNTHDDHPDYKPLTEAL 325
Query: 689 RNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIG 748
IK + IN+ R AE+A ++ Q++ + + P R+F+R+ V + G
Sbjct: 326 DKIKHITTIINEKKRDAEDAFAMLQIHQQVHGKVP--NNFVTPHRKFIREGAVHFGSSSG 383
Query: 749 GKKDRS--LFLFTDLIVCT 765
KD+ +FLF D+++ T
Sbjct: 384 SFKDKDPIVFLFNDMVMMT 402
>ref|NP_067585.1| breakpoint cluster region, isoform 2 [Homo sapiens]
emb|CAA68676.1| (Y00661) bcr polypeptide [Homo sapiens]
Length = 1227
Score = 108 bits (267), Expect = 5e-22
Identities = 79/264 (29%), Positives = 127/264 (47%), Gaps = 30/264 (11%)
Query: 511 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIFDQIPXXX 568
++MRK V +L +E++Y+ L L+ M+PLK + + ++ IF ++P
Sbjct: 496 LEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQQIETIFFKVPELY 554
Query: 569 XXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ +Q W QQ+VG L + S+ + +Y A++DN+ A + +A
Sbjct: 555 EIHKESYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQA 611
Query: 629 RPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDH 681
F + E R NK+ K +L L+ KPV R+ R L++ DLLKHTP HPDH
Sbjct: 612 NAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDH 671
Query: 682 PLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMV 741
PLL +A R + IN +EI + M + R+ L+ +
Sbjct: 672 PLLQDALRISQNFLSSIN----------------EEITPRRQSMTVKKGEHRQLLKDSFM 715
Query: 742 IEVKAIGGKKDRSLFLFTDLIVCT 765
+E+ G +K R +FLFTDL++CT
Sbjct: 716 VEL-VEGARKLRHVFLFTDLLLCT 738
>gb|AAB60390.1| (U07000) breakpoint cluster region protein [Homo sapiens]
Length = 936
Score = 108 bits (266), Expect = 7e-22
Identities = 79/264 (29%), Positives = 127/264 (47%), Gaps = 30/264 (11%)
Query: 511 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIFDQIPXXX 568
++MRK V +L +E++Y+ L L+ M+PLK + + ++ IF ++P
Sbjct: 161 LEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQQIETIFFKVPELY 219
Query: 569 XXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ +Q W QQ+VG L + S+ + +Y A++DN+ A + +A
Sbjct: 220 EIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQA 276
Query: 629 RPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDH 681
F + E R NK+ K +L L+ KPV R+ R L++ DLLKHTP HPDH
Sbjct: 277 NAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDH 336
Query: 682 PLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMV 741
PLL +A R + IN +EI + M + R+ L+ +
Sbjct: 337 PLLQDALRISQNFLSSIN----------------EEITPRRQSMTVKKGEHRQLLKDSFM 380
Query: 742 IEVKAIGGKKDRSLFLFTDLIVCT 765
+E+ G +K R +FLFTDL++CT
Sbjct: 381 VEL-VEGARKLRHVFLFTDLLLCT 403
>gb|AAB60389.1| (U07000) breakpoint cluster region protein [Homo sapiens]
Length = 889
Score = 108 bits (266), Expect = 7e-22
Identities = 79/264 (29%), Positives = 127/264 (47%), Gaps = 30/264 (11%)
Query: 511 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIFDQIPXXX 568
++MRK V +L +E++Y+ L L+ M+PLK + + ++ IF ++P
Sbjct: 114 LEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQQIETIFFKVPELY 172
Query: 569 XXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ +Q W QQ+VG L + S+ + +Y A++DN+ A + +A
Sbjct: 173 EIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQA 229
Query: 629 RPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDH 681
F + E R NK+ K +L L+ KPV R+ R L++ DLLKHTP HPDH
Sbjct: 230 NAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDH 289
Query: 682 PLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMV 741
PLL +A R + IN +EI + M + R+ L+ +
Sbjct: 290 PLLQDALRISQNFLSSIN----------------EEITPRRQSMTVKKGEHRQLLKDSFM 333
Query: 742 IEVKAIGGKKDRSLFLFTDLIVCT 765
+E+ G +K R +FLFTDL++CT
Sbjct: 334 VEL-VEGARKLRHVFLFTDLLLCT 356
>ref|XP_000840.1| breakpoint cluster region [Homo sapiens]
gb|AAB60388.1| (U07000) breakpoint cluster region protein [Homo sapiens]
Length = 1271
Score = 108 bits (266), Expect = 7e-22
Identities = 79/264 (29%), Positives = 127/264 (47%), Gaps = 30/264 (11%)
Query: 511 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIFDQIPXXX 568
++MRK V +L +E++Y+ L L+ M+PLK + + ++ IF ++P
Sbjct: 496 LEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQQIETIFFKVPELY 554
Query: 569 XXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ +Q W QQ+VG L + S+ + +Y A++DN+ A + +A
Sbjct: 555 EIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQA 611
Query: 629 RPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDH 681
F + E R NK+ K +L L+ KPV R+ R L++ DLLKHTP HPDH
Sbjct: 612 NAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDH 671
Query: 682 PLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMV 741
PLL +A R + IN +EI + M + R+ L+ +
Sbjct: 672 PLLQDALRISQNFLSSIN----------------EEITPRRQSMTVKKGEHRQLLKDSFM 715
Query: 742 IEVKAIGGKKDRSLFLFTDLIVCT 765
+E+ G +K R +FLFTDL++CT
Sbjct: 716 VEL-VEGARKLRHVFLFTDLLLCT 738
>gb|AAA65939.1| (M24603) bcr [Homo sapiens]
Length = 872
Score = 106 bits (262), Expect = 2e-21
Identities = 78/264 (29%), Positives = 127/264 (47%), Gaps = 30/264 (11%)
Query: 511 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIFDQIPXXX 568
++MRK V +L +E++Y+ L L+ M+PLK + + ++ IF ++P
Sbjct: 496 LEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQQIETIFFKVPELY 554
Query: 569 XXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ +Q W QQ+VG L + S+ + +Y A++DN+ A + +A
Sbjct: 555 EIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQA 611
Query: 629 RPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDH 681
F + E R NK+ K +L L+ KPV R+ R L++ DLLKHTP HPDH
Sbjct: 612 NAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDH 671
Query: 682 PLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMV 741
PLL +A R + IN +EI + M + R+ L+ +
Sbjct: 672 PLLQDALRISQNFLSSIN----------------EEITPRRQSMTVKKGEHRQLLKDSFM 715
Query: 742 IEVKAIGGKKDRSLFLFTDLIVCT 765
+E+ G +K R +FLFT+L++CT
Sbjct: 716 VEL-VEGARKLRHVFLFTELLLCT 738
>ref|NP_004318.2| breakpoint cluster region, isoform 1 [Homo sapiens]
sp|P11274|BCR_HUMAN BREAKPOINT CLUSTER REGION PROTEIN
pir||TVHUBR bcr (breakpoint cluster region) protein, splice form 1 - human
emb|CAA26441.1| (X02596) bcr [Homo sapiens]
Length = 1271
Score = 106 bits (262), Expect = 2e-21
Identities = 78/264 (29%), Positives = 127/264 (47%), Gaps = 30/264 (11%)
Query: 511 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIFDQIPXXX 568
++MRK V +L +E++Y+ L L+ M+PLK + + ++ IF ++P
Sbjct: 496 LEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQQIETIFFKVPELY 554
Query: 569 XXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ +Q W QQ+VG L + S+ + +Y A++DN+ A + +A
Sbjct: 555 EIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQA 611
Query: 629 RPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDH 681
F + E R NK+ K +L L+ KPV R+ R L++ DLLKHTP HPDH
Sbjct: 612 NAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDH 671
Query: 682 PLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMV 741
PLL +A R + IN +EI + M + R+ L+ +
Sbjct: 672 PLLQDALRISQNFLSSIN----------------EEITPRRQSMTVKKGEHRQLLKDSFM 715
Query: 742 IEVKAIGGKKDRSLFLFTDLIVCT 765
+E+ G +K R +FLFT+L++CT
Sbjct: 716 VEL-VEGARKLRHVFLFTELLLCT 738
>gb|AAF48732.1| (AE003505) CG8557 gene product [Drosophila melanogaster]
Length = 1783
Score = 106 bits (261), Expect = 3e-21
Identities = 61/229 (26%), Positives = 122/229 (52%), Gaps = 7/229 (3%)
Query: 1168 FTRGSLEDLLSVDPEA--YQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCIL 1225
F +G L+ L S D A VWLGT+ + +Y + + ++ + +V IL
Sbjct: 1029 FVKG-LDQLKSRDEPASLLGDLVWLGTDSRKILIYSARNPEQEEQLG-SYSVPGAVQRIL 1086
Query: 1226 YLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNR 1285
Y + V+V+L+ +++++R W ++ +++ LG + ++ + ++ C NR
Sbjct: 1087 YHFDAVYVALSGATVLIFRRGNDGVWQLRDPQTIRLGDTDLVVPSLLPINMCIYASCGNR 1146
Query: 1286 VLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVD 1345
V V++ +++ F V +++ V M S +G+W++LK S +CLYH +TF+ L +++
Sbjct: 1147 VYVMNALNGEIQRSFEVQHGATQQVNLMAHSGIGLWISLKNSTMLCLYHTETFKHLQDIN 1206
Query: 1346 VTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMP 1394
+ V R + + + + +TAL+ C+ LLWVGT+ G+ +T+P
Sbjct: 1207 IASSVLRHDGKKEQPLNN---SSVYVTALMACKGLLWVGTNVGIAVTIP 1252
Score = 105 bits (260), Expect = 3e-21
Identities = 75/313 (23%), Positives = 135/313 (42%), Gaps = 41/313 (13%)
Query: 514 RKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXX 573
R+H+ ++ +E SYV +L+ L+ Y +PL++ VL +P + +F +P
Sbjct: 458 RRHIVAAIVHSENSYVATLQRLVNDYKKPLEECSPPVL-NPVKIATLFHCLPDILHSHKL 516
Query: 574 XXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFL 633
+ C++ W +K+G V +F K L+ IYS +I+NF A + ++ ++ + A
Sbjct: 517 FRISLAECVRNWDRDEKIGDCFVSAFGKPQLLEIYSGFINNFSAAMELAKMEEKRKSALA 576
Query: 634 KFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQ 693
F + ++ + LM+KPVQR P++ L ++DLLK+TP+ H D L ++
Sbjct: 577 DFFKVKQISAHDRLSFFGLMVKPVQRFPQFILFLQDLLKYTPQGHHDRMSL-----HLSS 631
Query: 694 VAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDR 753
V+ V + R +L+ E ++ ME QA I K R
Sbjct: 632 VS------VSDSAGGHRPRYLLR--EDNVTHMEFNQAGF--------------IVKCKQR 669
Query: 754 SLFLFTDLIVCTTXXXXXXXXXXXXXXXYTAASVIDTASKYKMLWKLPLEDADIIKGASQ 813
L L D ++C + K W P+ D +I+ ++
Sbjct: 670 RLLLLNDKVICVSVAPKQSHD-------------FGATEKLTFKWMFPVNDVEIVDNSTS 716
Query: 814 ATNRENIQKAISR 826
AT + ++R
Sbjct: 717 ATLSRILTAGLNR 729
>ref|NP_031926.1| ect2 oncogene [Mus musculus]
sp|Q07139|ECT2_MOUSE ECT2 PROTEIN (ECT2 ONCOGENE)
pir||S32372 transforming protein (ect2) - mouse
gb|AAA37536.1| (L11316) ect2 [Mus musculus]
prf||1911407A oncogene ect2 [Mus musculus]
Length = 738
Score = 96.0 bits (235), Expect = 3e-18
Identities = 60/214 (28%), Positives = 111/214 (51%), Gaps = 5/214 (2%)
Query: 509 PQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQP--ENSVLCDPSLVDEIFDQIPX 566
P+ R VA L TE +YV L T++Q + PL++ + P + IF IP
Sbjct: 273 PKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPD 332
Query: 567 XXXXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAK 626
+ + W + +G + ++ ++KD LV Y +++ F +K+ + +
Sbjct: 333 IFDVHMKIKDDLEDLIANWDESRSIGDIFLK-YAKD-LVKTYPPFVNFFEMSKEMIIKCE 390
Query: 627 EARPAFLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLL 685
+ +P F FL+ + + + +Q+L +L+I+PVQR+P LL+ DL KHT +++PD L
Sbjct: 391 KQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLE 450
Query: 686 EAQRNIKQVAERINKGVRSAEEAERHARVLQEIE 719
+A ++K+V IN+ R E ++ V+ E++
Sbjct: 451 KAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVD 484
>dbj|BAB14498.1| (AK023267) unnamed protein product [Homo sapiens]
Length = 798
Score = 95.6 bits (234), Expect = 4e-18
Identities = 60/209 (28%), Positives = 109/209 (51%), Gaps = 5/209 (2%)
Query: 514 RKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQP--ENSVLCDPSLVDEIFDQIPXXXXXX 571
R VA L TE +YV L T++Q + PL++ + P + IF IP
Sbjct: 422 RWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVH 481
Query: 572 XXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPA 631
+ + W + +G + ++ +SKD LV Y +++ F +K+ + ++ +P
Sbjct: 482 TKIKDDLEDLIVNWDESKSIGDIFLK-YSKD-LVKTYPPFVNFFEMSKETIIKCEKQKPR 539
Query: 632 FLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRN 690
F FL+ + + + +Q+L +L+I+PVQR+P LL+ DL KHT +++PD L +A +
Sbjct: 540 FHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGS 599
Query: 691 IKQVAERINKGVRSAEEAERHARVLQEIE 719
+K+V IN+ R E ++ V+ E++
Sbjct: 600 LKEVMTHINEDKRKTEAQKQIFDVVYEVD 628
>gb|AAD47903.1|AF090533_1 (AF090533) unconventional myosin heavy chain MyoM [Dictyostelium
discoideum]
dbj|BAA84604.1| (AB017910) myoM [Dictyostelium discoideum]
Length = 1737
Score = 94.0 bits (230), Expect = 1e-17
Identities = 75/293 (25%), Positives = 133/293 (44%), Gaps = 25/293 (8%)
Query: 521 LLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXXXXXXVRH 580
L++TE+ YV L +++ ++ P+++ + L ++ +F I +
Sbjct: 1397 LIETERDYVRDLNIVVEVFLNPIREKQ---LLSAKDINSLFSNIEILFSINMNVLKALEK 1453
Query: 581 CMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSM 640
VG + + +Y+ Y N NA + K F ++LE M
Sbjct: 1454 DKDPLCENISVGQTFLDMSH---YLKMYTTYCSNQQNALKILEEEKIKNQPFREYLEFCM 1510
Query: 641 RENKEKQA-LSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERIN 699
++ + L+ +IKPVQRI +Y LL+K+ +K TP DHPD P L E + I + + IN
Sbjct: 1511 NDSVCRGLPLNSFIIKPVQRICKYPLLIKETIKFTPNDHPDKPALEEVDKKISDIVQSIN 1570
Query: 700 KGVRSAEEAERHARVLQEIEAHIEGMED--LQAPLRRFLRQEMVIEVKAIGGKK--DRSL 755
+ R+ E ++ + +++ I+G+ED L R L + V VK + + R+L
Sbjct: 1571 EAKRTLELFQK----IVDLQNSIDGLEDTNLMEQGRTLLMEGTVSAVKELNSEDSLSRTL 1626
Query: 756 FLFTDLIVCTTXXXXXXXXXXXXXXXYTAASVIDTASKYKMLWKLPLEDADII 808
FLF +LI+ + TA + T K K+ K+P+ D+ +I
Sbjct: 1627 FLFNNLILICSFGTNVLS---------TAINQFKT-KKLKLKAKIPISDSRLI 1669
>gb|AAF50508.1| (AE003557) pbl gene product [Drosophila melanogaster]
Length = 851
Score = 92.1 bits (225), Expect = 4e-17
Identities = 76/258 (29%), Positives = 120/258 (46%), Gaps = 16/258 (6%)
Query: 513 MRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQ--PENSVLCDPSLVDEIFDQIPXXXXX 570
MR + M TE +YV L T++ + L++ N L + S + IF
Sbjct: 384 MRFNHFMDFYTTESNYVGILDTILNLFKNKLEELAETNDPLLNKSEIKTIFGNFLPIHEV 443
Query: 571 XXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARP 630
+R W +G +++Q +D L+ Y Y++ F K+ ++ P
Sbjct: 444 HQSMLEHLRKLHANWREDCLIGDIIIQH--RDELIKAYPPYVNFFEQMKEQLQYCDREYP 501
Query: 631 AFLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQR 689
F FL+ + + + +Q L DLMI+PVQR+P LL+ D+LKHT + DH L EA +
Sbjct: 502 RFHAFLKINQTKPECGRQGLQDLMIRPVQRLPSISLLLNDILKHTTSGNADHGRLEEALK 561
Query: 690 NIKQVAERINKGVRSAEEAERHARVLQEIE---AHIEGMEDLQAPLRRFLRQEMVIEVK- 745
IKQV IN+ R E + +IE AH L + R F+ + V E+
Sbjct: 562 AIKQVTLHINEDKRRTESRMAIFDIFNDIEGCPAH------LVSSNRSFILKCEVNELSD 615
Query: 746 AIGGKKDR-SLFLFTDLI 762
++ G+ D L+LF+D I
Sbjct: 616 SLSGRGDSLVLYLFSDSI 633
>gb|AAD52845.1|AF136492_1 (AF136492) Pebble [Drosophila melanogaster]
Length = 853
Score = 92.1 bits (225), Expect = 4e-17
Identities = 76/258 (29%), Positives = 120/258 (46%), Gaps = 16/258 (6%)
Query: 513 MRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQ--PENSVLCDPSLVDEIFDQIPXXXXX 570
MR + M TE +YV L T++ + L++ N L + S + IF
Sbjct: 386 MRFNHFMDFYTTESNYVGILDTILNLFKNKLEELAETNDPLLNKSEIKTIFGNFLPIHEV 445
Query: 571 XXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARP 630
+R W +G +++Q +D L+ Y Y++ F K+ ++ P
Sbjct: 446 HQSMLEHLRKLHANWREDCLIGDIIIQH--RDELIKAYPPYVNFFEQMKEQLQYCDREYP 503
Query: 631 AFLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQR 689
F FL+ + + + +Q L DLMI+PVQR+P LL+ D+LKHT + DH L EA +
Sbjct: 504 RFHAFLKINQTKPECGRQGLQDLMIRPVQRLPSISLLLNDILKHTTSGNADHGRLEEALK 563
Query: 690 NIKQVAERINKGVRSAEEAERHARVLQEIE---AHIEGMEDLQAPLRRFLRQEMVIEVK- 745
IKQV IN+ R E + +IE AH L + R F+ + V E+
Sbjct: 564 AIKQVTLHINEDKRRTESRMAIFDIFNDIEGCPAH------LVSSNRSFILKCEVNELSD 617
Query: 746 AIGGKKDR-SLFLFTDLI 762
++ G+ D L+LF+D I
Sbjct: 618 SLSGRGDSLVLYLFSDSI 635
>pir||T18289 racGAP protein - slime mold (Dictyostelium discoideum)
emb|CAA71241.1| (Y10159) racGAP [Dictyostelium discoideum]
Length = 1335
Score = 90.9 bits (222), Expect = 9e-17
Identities = 89/364 (24%), Positives = 159/364 (43%), Gaps = 19/364 (5%)
Query: 514 RKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXX 573
R+ A L TEQ+YV+ L + +++P K+ + +IF+ +
Sbjct: 791 RRERAEETLTTEQTYVKQLTVVYDNFIEPYKKTQKCHGLTGEEFMDIFNCLEVILSSHKT 850
Query: 574 XXXX-VRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAF 632
+ M W ++ ++G + + + S + +Y Y++N+ + + KE F
Sbjct: 851 NLLKPIEDRMLVWDSKPQMGDIFLNNTS---FIKLYKHYVNNYDKSIRTLNQCKEKYDGF 907
Query: 633 LKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNI 691
++ EN +L ++ P+Q +PRY +L++DLLK+T DH D L EA I
Sbjct: 908 KTYMASLDYSENLSNLSLESFLVLPIQPLPRYVMLLQDLLKYTANDHEDFNQLCEALSTI 967
Query: 692 KQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKK 751
K + E IN E + + ++LQ ++ I+ M P LR+ V E A+ KK
Sbjct: 968 KDLTESIN---TKKSEEDNNTKILQ-VQEQIKDM----PPNTMTLRKRFVTE-GALTLKK 1018
Query: 752 DR-SLFLFTDLIVCTTXXXXXXXXXXXXXXXYTAASVIDTASKYKMLWKLPLEDADIIKG 810
D+ +FLFTD ++ T + + D + K++ +
Sbjct: 1019 DKYYVFLFTDRMILTKPGKEKKKFKNIINLSTASLNTTDEQNVLKVISQEGTFKFSTDNP 1078
Query: 811 ASQATNRENIQKAISRLDEDL--TTLGQMSKLSE-SLGFPH-QSLDDALRDLSAAMHRDL 866
A + ++I+ AI +DL T G+ + L+E S GF Q + L+ A L
Sbjct: 1079 AEREHWVKDIKDAIDTARQDLIQTAFGESTTLNEGSKGFNKIQDEKNMLKKQKLAQELAL 1138
Query: 867 SEKQ 870
SE++
Sbjct: 1139 SEEE 1142
Score = 57.0 bits (135), Expect = 1e-06
Identities = 42/206 (20%), Positives = 92/206 (44%), Gaps = 11/206 (5%)
Query: 514 RKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQ----PENSVLCDPSLVDEIFDQIPXXXX 569
++ +A L +E+ YV+SL + ++QP+K+ P V +L EI
Sbjct: 1129 KQKLAQELALSEEEYVDSLTYIYNVFLQPIKKSIDTPNQLVSYQENL--EISSNFETLFS 1186
Query: 570 XXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEAR 629
++ + W ++ + + ++ K + +Y+ Y+ N + + E
Sbjct: 1187 CHKTFLIALKERIAEWDSKPLMSDIFME---KAGFLKLYNYYVQNHTRSLQVLEHCIEKY 1243
Query: 630 PAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQR 689
F L++ E+ + L L+ +P++R+ +Y L+++++L++T H D+ L
Sbjct: 1244 SLFAIHLKRI--ESDQNTELKVLLAQPLRRVSKYYLVLREILQYTRPKHDDYDALNRVVA 1301
Query: 690 NIKQVAERINKGVRSAEEAERHARVL 715
N+K ++ N S AE ++ L
Sbjct: 1302 NLKDQTDKFNANSTSQMSAEAGSKYL 1327
>gb|AAA35594.1| (M15025) BCR-ABL protein [Homo sapiens]
Length = 693
Score = 90.9 bits (222), Expect = 9e-17
Identities = 62/201 (30%), Positives = 100/201 (48%), Gaps = 13/201 (6%)
Query: 511 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIFDQIPXXX 568
++MRK V +L +E++Y+ L L+ M+PLK + + ++ IF ++P
Sbjct: 496 LEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQQIETIFFKVPELY 554
Query: 569 XXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ +Q W QQ+VG L + S+ + +Y A++DN+ A + +A
Sbjct: 555 EIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQA 611
Query: 629 RPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDH 681
F + E R NK+ K +L L+ KPV R+ R L++ DLLKHTP HPDH
Sbjct: 612 NAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDH 671
Query: 682 PLLLEAQRNIKQVAERINKGV 702
PLL +A R + IN+ +
Sbjct: 672 PLLQDALRISQNFLSSINEEI 692
>pir||B47485 ABR protein 2 - human
Length = 813
Score = 89.7 bits (219), Expect = 2e-16
Identities = 68/265 (25%), Positives = 121/265 (45%), Gaps = 34/265 (12%)
Query: 511 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSL----VDEIFDQIPX 566
++MRK V L +E+ Y+ L L+ M+PLK + P L ++ IF +I
Sbjct: 43 LEMRKLVLSGFLASEEIYINQLEALLLP-MKPLKA--TATTSQPVLTIQQIETIFYKIQD 99
Query: 567 XXXXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAK 626
+ +Q W +Q +G L + S+ + +Y A++DN+ A +
Sbjct: 100 IYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNYKVALETAEKCS 156
Query: 627 EARPAFLKFLEQ-------SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHP 679
++ F K E+ +++ + L+ KP+ R+ R L++ DLLKHTP DHP
Sbjct: 157 QSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHP 216
Query: 680 DHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQE 739
D+PLL +A R + IN ++I+ + + R+ ++
Sbjct: 217 DYPLLQDALRISQNFLSSIN----------------EDIDPRRTAVTTPKGETRQLVKDG 260
Query: 740 MVIEVKAIGGKKDRSLFLFTDLIVC 764
++EV +K R +FLFTD+++C
Sbjct: 261 FLVEVSE-SSRKLRHVFLFTDVLLC 284
>sp|Q12979|ABR_HUMAN ACTIVE BREAKPOINT CLUSTER REGION-RELATED PROTEIN
pir||A49307 98K GTPase-activating protein ABR, brain - human
gb|AAC50063.1| (U01147) guanine nucleotide regulatory protein [Homo sapiens]
Length = 859
Score = 89.7 bits (219), Expect = 2e-16
Identities = 68/265 (25%), Positives = 121/265 (45%), Gaps = 34/265 (12%)
Query: 511 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSL----VDEIFDQIPX 566
++MRK V L +E+ Y+ L L+ M+PLK + P L ++ IF +I
Sbjct: 89 LEMRKLVLSGFLASEEIYINQLEALLLP-MKPLKA--TATTSQPVLTIQQIETIFYKIQD 145
Query: 567 XXXXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAK 626
+ +Q W +Q +G L + S+ + +Y A++DN+ A +
Sbjct: 146 IYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNYKVALETAEKCS 202
Query: 627 EARPAFLKFLEQ-------SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHP 679
++ F K E+ +++ + L+ KP+ R+ R L++ DLLKHTP DHP
Sbjct: 203 QSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHP 262
Query: 680 DHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQE 739
D+PLL +A R + IN ++I+ + + R+ ++
Sbjct: 263 DYPLLQDALRISQNFLSSIN----------------EDIDPRRTAVTTPKGETRQLVKDG 306
Query: 740 MVIEVKAIGGKKDRSLFLFTDLIVC 764
++EV +K R +FLFTD+++C
Sbjct: 307 FLVEVSE-SSRKLRHVFLFTDVLLC 330
>ref|NP_001083.1| active BCR-related gene [Homo sapiens]
pir||A47485 ABR protein 1 - human
gb|AAC37519.1| (L19704) alternative first exon [Homo sapiens]
Length = 822
Score = 89.7 bits (219), Expect = 2e-16
Identities = 68/265 (25%), Positives = 121/265 (45%), Gaps = 34/265 (12%)
Query: 511 VDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSL----VDEIFDQIPX 566
++MRK V L +E+ Y+ L L+ M+PLK + P L ++ IF +I
Sbjct: 52 LEMRKLVLSGFLASEEIYINQLEALLLP-MKPLKA--TATTSQPVLTIQQIETIFYKIQD 108
Query: 567 XXXXXXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAK 626
+ +Q W +Q +G L + S+ + +Y A++DN+ A +
Sbjct: 109 IYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNYKVALETAEKCS 165
Query: 627 EARPAFLKFLEQ-------SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHP 679
++ F K E+ +++ + L+ KP+ R+ R L++ DLLKHTP DHP
Sbjct: 166 QSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHP 225
Query: 680 DHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQE 739
D+PLL +A R + IN ++I+ + + R+ ++
Sbjct: 226 DYPLLQDALRISQNFLSSIN----------------EDIDPRRTAVTTPKGETRQLVKDG 269
Query: 740 MVIEVKAIGGKKDRSLFLFTDLIVC 764
++EV +K R +FLFTD+++C
Sbjct: 270 FLVEVSE-SSRKLRHVFLFTDVLLC 293
>dbj|BAA92229.1| (AK000004) FLJ00004 protein [Homo sapiens]
Length = 698
Score = 88.5 bits (216), Expect = 5e-16
Identities = 66/252 (26%), Positives = 114/252 (45%), Gaps = 15/252 (5%)
Query: 516 HVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXXXX 575
H+A LL TE++YV+ L L Q + L P ++ IF I
Sbjct: 224 HIAQELLHTEETYVKRLHLLDQVFCTRLTDAG----IPPEVIMGIFSNISSIHRFHGQFL 279
Query: 576 X--XVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFL 633
+ W ++G +L + + +Y Y+ NF A V + P F
Sbjct: 280 LPELKTRITEEWDTNPRLGDILQKLAP---FLKMYGEYVKNFDRAVGLVSTWTQRSPLFK 336
Query: 634 KFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIK 692
+ ++ L M++PVQR+PRYELL+KD LK P+D PD +A+R+++
Sbjct: 337 DVIHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRK---DAERSLE 393
Query: 693 QVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KK 751
++ N + + E+ ++L E+ + G ED+ P +++ + ++ A G +
Sbjct: 394 LISTAANHSNAAIRKVEKMHKLL-EVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQ 452
Query: 752 DRSLFLFTDLIV 763
DR LFLF +I+
Sbjct: 453 DRHLFLFNSMIL 464
>ref|NP_056574.1| faciogenital dysplasia homolog 3 [Mus musculus]
gb|AAC35431.1| (AF017369) faciogenital dysplasia protein 3 [Mus musculus]
Length = 733
Score = 87.4 bits (213), Expect = 1e-15
Identities = 69/262 (26%), Positives = 114/262 (43%), Gaps = 17/262 (6%)
Query: 506 CSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIP 565
CS PQ + H+A LL TE++YV+ L L Q + L + + + IF I
Sbjct: 148 CSDPQKLL--HIAQELLHTEEAYVKRLHLLDQVFCTKLTEAGIPL----EVTTGIFSNIS 201
Query: 566 XXXXXXXXXXX--XVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVR 623
+ + W ++G +L + + +Y Y+ NF A V
Sbjct: 202 SIYRFHGQFLLPELQKRITEEWDTNPRLGDILQKLAP---FLKMYGEYVKNFDRAMGLVS 258
Query: 624 VAKEARPAFLKFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHP 682
+ P F + ++ L M++PVQR+PRYELL+KD LK P D PD
Sbjct: 259 TWTQRSPQFKDVIHTIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPRDAPDRK 318
Query: 683 LLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVI 742
+ I A+ N +R E+ + L E+ + G ED+ P +++ +
Sbjct: 319 DAERSLELISTAADHSNAAIRKMEKMHK----LLEVYEQLGGEEDIVNPANELIKEGSIQ 374
Query: 743 EVKAIGG-KKDRSLFLFTDLIV 763
++ A G +DR LFLF ++++
Sbjct: 375 KLSAKNGTTQDRHLFLFNNVML 396
>ref|NP_032027.1| faciogenital dysplasia homolog [Mus musculus]
sp|P52734|FGD1_MOUSE PUTATIVE RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR (RHO/RAC GEF)
(FACIOGENITAL DYSPLASIA PROTEIN HOMOLOG)
gb|AAA96001.1| (U22325) Fgd1 [Mus musculus]
Length = 960
Score = 87.0 bits (212), Expect = 1e-15
Identities = 70/254 (27%), Positives = 119/254 (46%), Gaps = 12/254 (4%)
Query: 516 HVAMTLLDTEQSYVESLRTLMQGYM-QPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXXX 574
H+A LL TE++YV L L Q + + L++ N +V IF I
Sbjct: 375 HIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQF 434
Query: 575 XX-XVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFL 633
+ M+ W ++G +L + + +Y Y+ NF A + V E F
Sbjct: 435 LLPELEKRMEEWDRYPRIGDILQKLAP---FLKMYGEYVKNFDRAVELVNTWTERSTQFK 491
Query: 634 KFLEQSMRENKEKQ-ALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIK 692
+ + +E + L M++PVQRIPRYELL+KD L P PD +AQ++++
Sbjct: 492 VIIHEVQKEEACRNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSK---DAQKSLE 548
Query: 693 QVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KK 751
+A + + ER ++L+ E + G ED+ +P + +++ ++++ A G +
Sbjct: 549 LIATAAEHSNAAIRKMERMHKLLKVYEL-LGGEEDIVSPTKELIKEGHILKLSAKNGTTQ 607
Query: 752 DRSLFLFTD-LIVC 764
DR L LF D L+ C
Sbjct: 608 DRYLILFNDRLLYC 621
>ref|NP_004454.1| faciogenital dysplasia protein [Homo sapiens]
sp|P98174|FGD1_HUMAN PUTATIVE RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR (RHO/RAC GEF)
(FACIOGENITAL DYSPLASIA PROTEIN)
pir||A55380 faciogenital dysplasia-associated protein FGD1 - human
gb|AAA57004.1| (U11690) FGD1 [Homo sapiens]
Length = 961
Score = 86.2 bits (210), Expect = 2e-15
Identities = 70/254 (27%), Positives = 118/254 (45%), Gaps = 12/254 (4%)
Query: 516 HVAMTLLDTEQSYVESLRTLMQGYM-QPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXXX 574
H+A LL TE++YV L L Q + + L++ N +V IF I
Sbjct: 376 HIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQF 435
Query: 575 XX-XVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFL 633
+ M+ W ++G +L + + +Y Y+ NF A + V E F
Sbjct: 436 LLPELEKRMEEWDRYPRIGDILQKLAP---FLKMYGEYVKNFDRAVELVNTWTERSTQFK 492
Query: 634 KFLEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIK 692
+ + +E L M++PVQRIPRYELL+KD L P PD +AQ++++
Sbjct: 493 VIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSK---DAQKSLE 549
Query: 693 QVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KK 751
+A + + ER ++L+ E + G ED+ +P + +++ ++++ A G +
Sbjct: 550 LIATAAEHSNAAIRKMERMHKLLKVYEL-LGGEEDIVSPTKELIKEGHILKLSAKNGTTQ 608
Query: 752 DRSLFLFTD-LIVC 764
DR L LF D L+ C
Sbjct: 609 DRYLILFNDRLLYC 622
>gb|AAC27698.1| (AF038388) actin-filament binding protein Frabin [Rattus
norvegicus]
Length = 766
Score = 85.4 bits (208), Expect = 4e-15
Identities = 66/250 (26%), Positives = 112/250 (44%), Gaps = 10/250 (4%)
Query: 517 VAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXXXXX 576
+A LL TE++YV L L Q + L + N +V++IF I
Sbjct: 210 IATELLLTERAYVSRLNLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLL 269
Query: 577 -XVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKF 635
+ MQ W ++G +L + + +Y Y+ F NA + V+ E P F
Sbjct: 270 PELEKRMQEWETTPRIGDILQKLAP---FLKMYGEYVKGFDNAVELVKNMTERVPQFKSV 326
Query: 636 LEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQV 694
E+ ++ L M++P+QRIPRYE+L+KD LK D PD ++ I
Sbjct: 327 TEEIQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDAPDWNDAKKSLEIISTA 386
Query: 695 AERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIG-GKKDR 753
A N +R E ++ L EI + ED+ P +++ ++++ A ++R
Sbjct: 387 ASHSNSAIRKMENLKK----LLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQER 442
Query: 754 SLFLFTDLIV 763
LFLF ++++
Sbjct: 443 YLFLFNNMLL 452
>pir||TVHUA2 bcr (breakpoint cluster region) protein, splice form 3 - human
(fragment)
Length = 693
Score = 84.7 bits (206), Expect = 7e-15
Identities = 60/199 (30%), Positives = 97/199 (48%), Gaps = 13/199 (6%)
Query: 513 MRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPSLVDEIFDQIPXXXXX 570
+RK V +L +E++Y+ L L+ M+PLK + + ++ IF ++P
Sbjct: 498 VRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQQIETIFFKVPELYEI 556
Query: 571 XXXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARP 630
+ +Q W QQ+VG L + S+ + +Y A++DN+ A + +A
Sbjct: 557 HKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANA 613
Query: 631 AFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPL 683
F + E R NK+ K +L L+ KPV R+ R L++ DLLKHT HPDHPL
Sbjct: 614 QFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTGASHPDHPL 673
Query: 684 LLEAQRNIKQVAERINKGV 702
L +A R + IN+ +
Sbjct: 674 LQDALRISQNFLSSINEEI 692
>dbj|BAA92600.1| (AB037783) KIAA1362 protein [Homo sapiens]
Length = 699
Score = 83.9 bits (204), Expect = 1e-14
Identities = 83/345 (24%), Positives = 145/345 (41%), Gaps = 23/345 (6%)
Query: 516 HVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQI----PXXXXXX 571
H+A ++ +E+ +V+ L+ L + + L P + D I +QI P
Sbjct: 206 HIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQ-LGKPVIEDRILNQILYYLPQLYELN 264
Query: 572 XXXXXXVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPA 631
+ M W QQ++ + V+ K + +YS YI F + + P
Sbjct: 265 RDLLKELEERMLHWTEQQRIADIFVK---KGPYLKMYSTYIKEFDKNIALLDEQCKKNPG 321
Query: 632 FLKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRN 690
F + + M AL ++KPVQRIP+Y LL+ D LK+ ED D+ +A
Sbjct: 322 FAAVVREFEMSPCCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAV 381
Query: 691 IKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGK 750
+ +VA N ++ + ++ L +I+ + G ++ P R FL++ +++++
Sbjct: 382 VIEVANHANDTMKQGDNFQK----LMQIQYSLNGHHEIVQPGRVFLKEGILMKLSR-KVM 436
Query: 751 KDRSLFLFTDLIVCTTXXXXXXXXXXXXXXXYTAASVIDTASKYKMLWKLPLEDADIIKG 810
+ R FLF D ++ TT T Y+ K+ + I
Sbjct: 437 QPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILS 496
Query: 811 ASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGF-PHQSLDDA 854
AS AT R+ +AISR E+ + + F P +SLD+A
Sbjct: 497 ASSATERDEWLEAISRAIEEYA--------KKRITFCPSRSLDEA 533
>gb|AAF50584.1| (AE003559) CG8606 gene product [Drosophila melanogaster]
gb|AAG18329.1|AF255674_1 (AF255674) rho guanine nucleotide exchange factor 4 [Drosophila
melanogaster]
Length = 647
Score = 83.5 bits (203), Expect = 2e-14
Identities = 64/255 (25%), Positives = 119/255 (46%), Gaps = 17/255 (6%)
Query: 510 QVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXXX 569
++ R+ ++ +E+SY+E L LM +++PLK+ + D S +F QI
Sbjct: 67 RLGFRRQAIQEIISSEKSYLEQLELLMNFFVRPLKE---QAIIDCSNHTLLFGQIEMIHN 123
Query: 570 XXXXXXXXVRHCMQTW-HAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEA 628
+ M+ HA K+ +YS Y ++ A ++
Sbjct: 124 LNGEFLRELEANMENVAHAFLKMAPFF----------KLYSVYAFDYRGALFIIQDLISK 173
Query: 629 RPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQ 688
P F KFLEQ+ + ++ L+ LMI P+QR+PRY+LL++ +L +T D+ LL E+
Sbjct: 174 NPVFRKFLEQTESRPEVQRKLNSLMIVPIQRVPRYKLLLEQVLLYTSPADADYKLLKESV 233
Query: 689 RNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIG 748
+ I+ A IN V EE E ++ + + ++ P RR +++ ++ ++ G
Sbjct: 234 KEIEATASHINTCV---EEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQKITHKG 290
Query: 749 GKKDRSLFLFTDLIV 763
+ R L +D+ +
Sbjct: 291 TEIKRYCVLMSDIFM 305
>gb|AAC35432.1| (AF017370) faciogenital dysplasia protein [Danio rerio]
Length = 621
Score = 83.1 bits (202), Expect = 2e-14
Identities = 70/253 (27%), Positives = 115/253 (44%), Gaps = 17/253 (6%)
Query: 516 HVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXXXX 575
++A LL TE++YV+ L L Q + L E + D ++ IF I
Sbjct: 165 NIAKELLQTEEAYVKRLNLLDQVFCARLT--EAGIPTD--VITGIFSNISCIHRFHQQFL 220
Query: 576 XXVRHCM--QTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFL 633
H Q W ++G +L + + +Y Y+ NF + + V + + F
Sbjct: 221 LPELHTRITQEWSCNPRIGDILQKLAP---FLKMYGEYVKNFDRSMELVSLWTQRSGTF- 276
Query: 634 KFLEQSMRENKE--KQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNI 691
K QS+++ + L M++PVQRIPRYELL+KD LK PE DH A I
Sbjct: 277 KSTVQSIQKQEVCGNLTLQHHMLEPVQRIPRYELLLKDYLKKLPEGAADHRDAQNALELI 336
Query: 692 KQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGK- 750
A N +R E+ + L E+ + G ED+ P +++ + ++ A G
Sbjct: 337 STAANHSNAAIRKMEKMHK----LLEVYERLGGEEDIVNPANELIKEGHIKKMSAKNGSA 392
Query: 751 KDRSLFLFTDLIV 763
+DR L+LF ++++
Sbjct: 393 QDRYLYLFNNMVL 405
>gb|AAD29952.1|AF114487_1 (AF114487) intersectin long isoform [Homo sapiens]
Length = 1721
Score = 81.1 bits (197), Expect = 8e-14
Identities = 66/259 (25%), Positives = 125/259 (47%), Gaps = 27/259 (10%)
Query: 521 LLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXXXXXXVRH 580
L+ TE++YV L+ + + + +PL + E L V IF +R
Sbjct: 1245 LIVTEENYVNDLQLVTEIFQKPLMESE---LLTEKEVAMIFVNWKELIMCNIKLLKALR- 1300
Query: 581 CMQTWHAQQKVGALLVQSFSKDVLVNI--YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQ 638
++ + +K+ ++ L ++ Y + LN ++ + P F +F+++
Sbjct: 1301 -VRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKR 1359
Query: 639 SMRENKEK-QALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAER 697
+ + K LS ++KP+QR+ RY L++K++L++TPE+HPDH L A +++ +
Sbjct: 1360 LAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQ 1419
Query: 698 INKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPL-----------RRFLRQEMVIEVKA 746
+N+GVR E ++R L+ I+AH++ E L L R+FL + + K+
Sbjct: 1420 VNEGVREKENSDR----LEWIQAHVQ-CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKS 1474
Query: 747 IGGKKDRSLFLFTDLIVCT 765
K+ FLF D ++ T
Sbjct: 1475 ---NKELYGFLFNDFLLLT 1490
>gb|AAF45386.1| (AE002567) EG:23E12.2 gene product [Drosophila melanogaster]
Length = 718
Score = 80.4 bits (195), Expect = 1e-13
Identities = 65/235 (27%), Positives = 107/235 (44%), Gaps = 42/235 (17%)
Query: 604 LVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALS--DLMIKPVQRIP 661
+ ++YSA++ N+ NA + V+ P F K + + + +Q+L+ DL+ KPV R+
Sbjct: 67 MFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNLQTEQSLTLEDLLHKPVARVQ 126
Query: 662 RYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERIN-KGVRSAEEAERHARVLQEIEA 720
L+ DLL+ TP HPDH L +AQ+ I+ + N R E+ R+
Sbjct: 127 INALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRN--------- 177
Query: 721 HIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTXXXXXXXXXXXXXX 780
LRR +R ++E+ G +K R LFLF D+I C
Sbjct: 178 -----------LRRMVRNSFIVEL-VDGHRKLRHLFLFNDVIACAKYKA----------- 214
Query: 781 XYTAASVIDTASKYKMLWKLPLEDADIIKGASQATN-RENIQKAISRLDEDLTTL 834
ID Y++ W +PL+D I + A A +E+ IS++ +L ++
Sbjct: 215 --LGRDRID----YELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNLRSV 263
>emb|CAA21413.1| (AL031884) /prediction=(method:""genefinder"",
version:""084"")~/prediction=(method:""genscan"",
version:""1.0"")~/match=(desc:""BREAKPOINT CLUSTER
REGION PROTEIN"", species:""HOMO SAPIENS (HUMAN)"",
ranges:(query:22532..22813, target:SWISS-PROT::P1127>
Length = 658
Score = 80.4 bits (195), Expect = 1e-13
Identities = 65/235 (27%), Positives = 107/235 (44%), Gaps = 42/235 (17%)
Query: 604 LVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALS--DLMIKPVQRIP 661
+ ++YSA++ N+ NA + V+ P F K + + + +Q+L+ DL+ KPV R+
Sbjct: 67 MFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNLQTEQSLTLEDLLHKPVARVQ 126
Query: 662 RYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERIN-KGVRSAEEAERHARVLQEIEA 720
L+ DLL+ TP HPDH L +AQ+ I+ + N R E+ R+
Sbjct: 127 INALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRN--------- 177
Query: 721 HIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTXXXXXXXXXXXXXX 780
LRR +R ++E+ G +K R LFLF D+I C
Sbjct: 178 -----------LRRMVRNSFIVEL-VDGHRKLRHLFLFNDVIACAKYKA----------- 214
Query: 781 XYTAASVIDTASKYKMLWKLPLEDADIIKGASQATN-RENIQKAISRLDEDLTTL 834
ID Y++ W +PL+D I + A A +E+ IS++ +L ++
Sbjct: 215 --LGRDRID----YELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNLRSV 263
>ref|NP_003015.1| intersectin 1 (SH3 domain protein); intersectin (SH3 domain protein
1A); SH3 domain protein-1A; human intersectin-SH3
domain-containing protein SH3P17 [Homo sapiens]
gb|AAC78611.1| (AF064244) intersectin long form [Homo sapiens]
Length = 1721
Score = 80.4 bits (195), Expect = 1e-13
Identities = 66/259 (25%), Positives = 124/259 (47%), Gaps = 27/259 (10%)
Query: 521 LLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXXXXXXVRH 580
L+ TE++YV L+ + + + +PL + E L V IF +R
Sbjct: 1245 LIVTEENYVNDLQLVTEIFQKPLMESE---LLTEKEVAMIFVNWKELIMCNIKLLKALR- 1300
Query: 581 CMQTWHAQQKVGALLVQSFSKDVLVNI--YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQ 638
++ + +K+ ++ L ++ Y + LN ++ + P F +F+++
Sbjct: 1301 -VRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKR 1359
Query: 639 SMRENKEK-QALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAER 697
+ + K LS ++KP+QR+ RY L++K++L++TPE+HPDH L A +++ +
Sbjct: 1360 LEMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQ 1419
Query: 698 INKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPL-----------RRFLRQEMVIEVKA 746
+N+GVR E ++R L+ I+AH++ E L L R+FL + + K
Sbjct: 1420 VNEGVREKENSDR----LEWIQAHVQ-CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAK- 1473
Query: 747 IGGKKDRSLFLFTDLIVCT 765
K+ FLF D ++ T
Sbjct: 1474 --NNKELYGFLFNDFLLLT 1490
>ref|NP_034717.1| intersectin (SH3 domain protein 1A); intersection (SH3 domain protein
1A); Eh domain, SH3 domain regulator of endocytosis 1
[Mus musculus]
gb|AAD19749.1| (AF132481) Ese1L protein [Mus musculus]
Length = 1714
Score = 80.0 bits (194), Expect = 2e-13
Identities = 66/259 (25%), Positives = 125/259 (47%), Gaps = 27/259 (10%)
Query: 521 LLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPXXXXXXXXXXXXVRH 580
L+ TE++YV L+ + + + +PL + E L V IF +R
Sbjct: 1238 LIVTEENYVNDLQLVTEIFQKPLTESE---LLTEKEVAMIFVNWKELIMCNIKLLKALR- 1293
Query: 581 CMQTWHAQQKVGALLVQSFSKDVLVNI--YSAYIDNFLNAKDAVRVAKEARPAFLKFLEQ 638
++ + +K+ ++ L ++ Y + LN ++ + P F +F+++
Sbjct: 1294 -VRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSCQLNGAALIQQKTDEAPDFKEFVKR 1352
Query: 639 SMRENKEK-QALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAER 697
+ + K LS ++KP+QR+ RY L++K++L++TPE+HPDH L A +++ +
Sbjct: 1353 LAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQ 1412
Query: 698 INKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPL-----------RRFLRQEMVIEVKA 746
+N+GVR E ++R L+ I+AH++ E L L R+FL + + K+
Sbjct: 1413 VNEGVREKENSDR----LEWIQAHVQ-CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKS 1467
Query: 747 IGGKKDRSLFLFTDLIVCT 765
K+ FLF D ++ T
Sbjct: 1468 ---NKELYGFLFNDFLLLT 1483
>dbj|BAA92653.1| (AB037836) KIAA1415 protein [Homo sapiens]
Length = 1539
Score = 78.0 bits (189), Expect = 7e-13
Identities = 57/178 (32%), Positives = 91/178 (51%), Gaps = 19/178 (10%)
Query: 600 SKDVLVNIYSAYIDNFL-------NAKDAVRVAKEAR--PAFLKFLEQSMRENKEKQA-- 648
S+ L N++ + D F N + A+R+ E P FL M K
Sbjct: 7 SQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDI 66
Query: 649 -LSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEE 707
L ++ P+QRI +Y LL+K+L K TP HPDHP + A + +K V IN+ R E+
Sbjct: 67 PLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEK 126
Query: 708 AERHARVLQEIEAHIEGME--DLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIV 763
E L+++++HIEG E +L + L Q ++++ A G ++R+ FLF +L+V
Sbjct: 127 LE----ALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISA-GNIQERAFFLFDNLLV 179
Database: nr
Number of letters in database: 182,691,300
Number of sequences in database: 580,189
Lambda K H
0.317 0.134 0.403
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 484282445
Number of Sequences: 580189
Number of extensions: 19052818
Number of successful extensions: 53019
Number of sequences better than 10.0: 246
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 65
Number of HSP's that attempted gapping in prelim test: 52414
Number of HSP's gapped (non-prelim): 469
length of query: 1510
length of database: 182,691,300
effective HSP length: 59
effective length of query: 1451
effective length of database: 148,460,149
effective search space: 215415676199
effective search space used: 215415676199
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 77 (34.4 bits)
