Score E
Sequences producing significant alignments: (bits) Value
ref|NP_055674.1| KIAA0672 gene product [Homo sapiens] >gi|3... 1288 0.0
dbj|BAB12426.1| (AB042827) Nadrin [Rattus norvegicus] 580 e-164
pir||T12533 hypothetical protein DKFZp434B034.1 - human (fr... 519 e-146
dbj|BAB14506.1| (AK023281) unnamed protein product [Homo sa... 463 e-129
ref|XP_001062.1| hypothetical protein dJ37E16.5 [Homo sapiens] 417 e-115
emb|CAB42896.1| (Z83844) dJ37E16.2 (SH3-domain binding prot... 331 2e-89
ref|NP_033190.1| SH3-domain binding protein 1 [Mus musculus... 319 7e-86
gb|AAF55715.1| (AE003728) CG4755 gene product [Drosophila m... 221 3e-56
gb|AAB22808.1| 3BP-1=Bcr/guanosine triphosphatase-activatin... 178 3e-43
gb|AAF59636.1| (AC024755) contains similarity to TR:O75160 ... 152 1e-35
emb|CAB75671.1| (AL157480) hypothetical protein [Homo sapiens] 143 9e-33
dbj|BAA96025.1| (AB040934) KIAA1501 protein [Homo sapiens] 101 4e-20
dbj|BAA92662.1| (AB037845) KIAA1424 protein [Homo sapiens] 100 6e-20
gb|AAF80386.1|AF159851_1 (AF159851) Rho GAP p190-A [Homo sa... 98 5e-19
sp|P34588|YN54_CAEEL HYPOTHETICAL 80.8 KD PROTEIN ZC21.4 IN... 96 1e-18
gb|AAA18934.1| (U02289) GTPase-activating protein [Caenorha... 96 1e-18
pir||S44876 ZC21.4 protein - Caenorhabditis elegans >gi|289... 96 1e-18
gb|AAF49953.1| (AE003542) CG6811 gene product [Drosophila m... 96 2e-18
ref|NP_004136.1| myosin IXB [Homo sapiens] >gi|1147783|gb|A... 95 2e-18
ref|NP_056557.1| myosin IXb [Mus musculus] >gi|6002741|gb|A... 94 4e-18
ref|NP_033836.1| rho GTPase activating protein 5 [Mus muscu... 94 4e-18
ref|NP_037116.1| unconventional myosin from rat 3 [Rattus n... 94 6e-18
gb|AAF00119.1|AF143684_1 (AF143684) unconventional myosin I... 93 1e-17
dbj|BAA86518.1| (AB033030) KIAA1204 protein [Homo sapiens] 91 5e-17
ref|NP_002538.1| oligophrenin 1, Rho-GTPase acivating prote... 91 5e-17
gb|AAF53844.1| (AE003664) CdGAPr gene product [Drosophila m... 90 6e-17
gb|AAF44627.1| (AF218776) GTPase activating protein [Drosop... 90 6e-17
pir||T27959 hypothetical protein ZK669.1b - Caenorhabditis ... 90 8e-17
pir||T27958 hypothetical protein ZK669.1a - Caenorhabditis ... 90 8e-17
pir||A38218 GAP-associated protein p190 - rat 90 1e-16
ref|NP_064656.1| Cdc42 GTPase-activating protein [Mus muscu... 89 1e-16
gb|AAB84002.1| (AF027687) GTPase activating protein homolog... 89 2e-16
gb|AAB82943.1| (AF029913) GTPase activating protein homolog... 89 2e-16
pdb|1TX4|A Chain A, RhoRHOGAPGDP(DOT)ALF4 COMPLEX 89 2e-16
ref|NP_001164.1| Rho GTPase activating protein 5; RhoGAP5; ... 89 2e-16
pdb|1GRN|B Chain B, Crystal Structure Of The Cdc42CDC42GAPA... 88 4e-16
pdb|2NGR|B Chain B, Transition State Complex For Gtp Hydrol... 88 4e-16
pdb|1AM4|A Chain A, Complex Between Cdc42hs.Gmppnp And P50 ... 88 4e-16
pdb|1RGP| Gtpase-Activation Domain From Rhogap 88 4e-16
pir||A49678 GTPase-activating protein rhoGAP - human (fragm... 88 4e-16
ref|NP_004299.1| Rho GTPase activating protein 1; RhoGAP; p... 88 4e-16
gb|AAF22154.1|AF133093_9 (AF133093) protein with characteri... 87 7e-16
gb|AAF46047.1| (AE003434) CG3208 gene product [Drosophila m... 87 9e-16
pir||T39954 probable gtpase activating protein homolog - fi... 87 9e-16
pir||T18289 racGAP protein - slime mold (Dictyostelium disc... 86 1e-15
pir||T20802 hypothetical protein F12F6.5 - Caenorhabditis e... 85 2e-15
sp|P98171|RHG4_HUMAN RHO-GTPASE-ACTIVATING PROTEIN 4 (RHO-G... 85 3e-15
emb|CAB70766.1| (AL137485) hypothetical protein [Homo sapiens] 85 4e-15
pir||B53764 beta2-chimerin, cerebellar - rat (fragment) 85 4e-15
ref|XP_000841.1| breakpoint cluster region [Homo sapiens] 84 5e-15
>ref|NP_055674.1| KIAA0672 gene product [Homo sapiens]
dbj|BAA31647.1| (AB014572) KIAA0672 protein [Homo sapiens]
Length = 818
Score = 1288 bits (3296), Expect = 0.0
Identities = 667/818 (81%), Positives = 667/818 (81%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA
Sbjct: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
Query: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV
Sbjct: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
Query: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTXXXXXXXXXXQPAGAKADALR 180
IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQT QPAGAKADALR
Sbjct: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR 180
Query: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI
Sbjct: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
Query: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXX 300
KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAP
Sbjct: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300
Query: 301 XXXXXXDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL 360
DCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL
Sbjct: 301 KLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL 360
Query: 361 QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNIT 420
QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNIT
Sbjct: 361 QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNIT 420
Query: 421 EMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPA 480
EMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPA
Sbjct: 421 EMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPA 480
Query: 481 DRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCXX 540
DRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSC
Sbjct: 481 DRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAP 540
Query: 541 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQPGPERTSTTKSKELSPGSA 600
QPGPERTSTTKSKELSPGSA
Sbjct: 541 PSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSA 600
Query: 601 QKGSPGSSQGTACXXXXXXXXXXXXXXXXXXXXXXXXXXXXHTLRKVSKKLAPIPPKVPF 660
QKGSPGSSQGTAC HTLRKVSKKLAPIPPKVPF
Sbjct: 601 QKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPIPPKVPF 660
Query: 661 GQPGAMADQSAGQLXXXXXXXXXXXXXXXXXXXXXQGYXXXXXXXXXXXXXXXXXXXVFT 720
GQPGAMADQSAGQL QGY VFT
Sbjct: 661 GQPGAMADQSAGQLSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSVFT 720
Query: 721 STLSKSXXXXXXXXXXXXXXXXXXXVNLSASSPQSTEAPMLDGMSPGESMSTDLVHFDIP 780
STLSKS VNLSASSPQSTEAPMLDGMSPGESMSTDLVHFDIP
Sbjct: 721 STLSKSRPTPKPRQRPTLPPPQPPTVNLSASSPQSTEAPMLDGMSPGESMSTDLVHFDIP 780
Query: 781 SIHIELGSTLRLSPLEHMRRHSVTDKRDSEEESESTAL 818
SIHIELGSTLRLSPLEHMRRHSVTDKRDSEEESESTAL
Sbjct: 781 SIHIELGSTLRLSPLEHMRRHSVTDKRDSEEESESTAL 818
>dbj|BAB12426.1| (AB042827) Nadrin [Rattus norvegicus]
Length = 780
Score = 580 bits (1479), Expect = e-164
Identities = 286/495 (57%), Positives = 366/495 (73%), Gaps = 9/495 (1%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
MKKQFNRM+QLANQTVGRAEKTEVLSEDLLQ+E+RL+ V+ + H +HK+L AC QGQ G
Sbjct: 1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSMCHHSHKRLIACFQGQHGT 60
Query: 61 EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120
+A++R KKLPLT LAQ + E SA L +++LLGKML+ CG+ E++LA EL E+ VE+++
Sbjct: 61 DAERRHKKLPLTALAQNMQEASAQL-EESLLGKMLETCGDAENQLAFELSQHEVFVEKEI 119
Query: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTXXXXXXXXXXQPAGAKADALR 180
++PL+ +AEVEIPNIQKQRK LA+LVLD DS R RW Q P+ K D L+
Sbjct: 120 MDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPS--KIDTLK 177
Query: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240
EEM+EA N+VE C+DQL+ADMY+F+AKE +Y +F TL+E QA+YHRK+L +L+ LP++
Sbjct: 178 EEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKALPEM 237
Query: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXX 300
+A Q+ W EKP+FG PLEEHL SGREIA PIEACV +LLE GM+EEGLFR+
Sbjct: 238 RAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLK 297
Query: 301 XXXXXXDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL 360
DC + E+ +DPHA+AGALKSYLRELPEPLMTF LY+EW Q ++VQ+QDKKL
Sbjct: 298 KLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFSLYEEWTQVASVQDQDKKL 357
Query: 361 QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNIT 420
Q LW C+KLP N N RYLIKFL+KL++ DVNKMTPSN+AIVLGPNLLW + EG +
Sbjct: 358 QYLWTTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWAKQEGTLA 417
Query: 421 EMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPA 480
E+ S+ +V +IEPIIQHADWFFPGE+EFN++ + P+ N+N+SS D D
Sbjct: 418 EIAAATSVHVVAVIEPIIQHADWFFPGEVEFNVSEAF-VPL-ATPNSNHSSHTGNDSDSG 475
Query: 481 DRRQPEQARRPLSVA 495
+ +RP S+A
Sbjct: 476 TL----ERKRPASMA 486
>pir||T12533 hypothetical protein DKFZp434B034.1 - human (fragment)
emb|CAB46376.1| (AL096728) hypothetical protein [Homo sapiens]
Length = 413
Score = 519 bits (1322), Expect = e-146
Identities = 280/417 (67%), Positives = 280/417 (67%), Gaps = 6/417 (1%)
Query: 356 QDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQA 415
QDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQA
Sbjct: 1 QDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQA 60
Query: 416 EGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSP 475
EGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSP
Sbjct: 61 EGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSP 120
Query: 476 DMDPADRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRK 535
DMDPADRRQPEQARRPLSVATDNMMLEFYKKDG MGV VMDTNWVARRGSSAGRK
Sbjct: 121 DMDPADRRQPEQARRPLSVATDNMMLEFYKKDG------MGVMVMDTNWVARRGSSAGRK 174
Query: 536 VSCXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQPGPERTSTTKSKEL 595
VSC QPGPERTSTTKSKEL
Sbjct: 175 VSCAPPSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPGPERTSTTKSKEL 234
Query: 596 SPGSAQKGSPGSSQGTACXXXXXXXXXXXXXXXXXXXXXXXXXXXXHTLRKVSKKLAPIP 655
SPGSAQKGSPGSSQGTAC HTLRKVSKKLAPIP
Sbjct: 235 SPGSAQKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPIP 294
Query: 656 PKVPFGQPGAMADQSAGQLXXXXXXXXXXXXXXXXXXXXXQGYXXXXXXXXXXXXXXXXX 715
PKVPFGQPGAMADQSAGQ QGY
Sbjct: 295 PKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLAS 354
Query: 716 XXVFTSTLSKSXXXXXXXXXXXXXXXXXXXVNLSASSPQSTEAPMLDGMSPGESMST 772
VFTSTLSKS VNLSASSPQSTEAPMLDGMSPGESMST
Sbjct: 355 PSVFTSTLSKSRPTPKPRQRPTLPPPQPPTVNLSASSPQSTEAPMLDGMSPGESMST 411
>dbj|BAB14506.1| (AK023281) unnamed protein product [Homo sapiens]
Length = 726
Score = 463 bits (1179), Expect = e-129
Identities = 220/399 (55%), Positives = 287/399 (71%), Gaps = 2/399 (0%)
Query: 87 DDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLV 146
+D+LLGKML+ CG+ E++LA EL E+ VE+++++PL+ +AEVEIPNIQKQRK LA+LV
Sbjct: 9 EDSLLGKMLETCGDAENQLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLV 68
Query: 147 LDMDSSRTRWQQTXXXXXXXXXXQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVA 206
LD DS R RW Q P+ K D L+EEM+EA N+VE C+DQL+ADMY+F+A
Sbjct: 69 LDWDSVRARWNQAHKSSGTNFQGLPS--KIDTLKEEMDEAGNKVEQCKDQLAADMYNFMA 126
Query: 207 KEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGR 266
KE +Y +F TL+E QA+YHRK+L +L+ LP+++A Q+ W EKP+FG PL EHL SGR
Sbjct: 127 KEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLAEHLKRSGR 186
Query: 267 EIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVDVQEYSADPHAIAGA 326
EIA PIEACV +LLE GM+EEGLFR+ DC + E+ +DPHA+AGA
Sbjct: 187 EIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGA 246
Query: 327 LKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLS 386
LKSYLRELPEPLMTF LY+EW Q ++VQ+QDKKLQ LW C+KLP N N RYLIKFL+
Sbjct: 247 LKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLA 306
Query: 387 KLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFP 446
KL++ DVNKMTPSN+AIVLGPNLLW + EG + EM S+ +V +IEPIIQHADWFFP
Sbjct: 307 KLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFP 366
Query: 447 GEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPADRRQP 485
E+EFN++ + + N ++ + D +R++P
Sbjct: 367 EEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRP 405
>ref|XP_001062.1| hypothetical protein dJ37E16.5 [Homo sapiens]
Length = 1803
Score = 417 bits (1061), Expect = e-115
Identities = 232/522 (44%), Positives = 322/522 (61%), Gaps = 31/522 (5%)
Query: 1 MKKQFNRMRQLANQ-TVGRAEKT-EVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQ 58
MK+Q +RMRQLA ++GR +T E L EDLLQVE+RLE K+ +H+ HK+L ACLQGQ
Sbjct: 772 MKRQLHRMRQLAQTGSLGRTPETAEFLGEDLLQVEQRLEPAKRAAHNIHKRLQACLQGQS 831
Query: 59 GAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVER 118
GA+ DKR KKLPL L+ + E L D+ +GK L++ +++LA+ L FE+ +ER
Sbjct: 832 GADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLER 891
Query: 119 DVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTXXXXXXXX---------XX 169
DV++PL L+E E+P I K +K L KLV D ++ ++R Q
Sbjct: 892 DVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHSH 951
Query: 170 QPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKS 229
K + L+EE EE +VE CRD+ AD+Y FV KE YANYF L+E+QA+YHR+S
Sbjct: 952 TTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLEIQADYHRRS 1011
Query: 230 LTLLQAVLPQIKAQQEAWVEKPS---------FGKPLEEHLTISGREIAFPIEACVTMLL 280
L+ L L +++ PS +G L HL GREIA PIEACV MLL
Sbjct: 1012 LSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMMLL 1071
Query: 281 ECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMT 340
GM+EEGLFR+A ++E+ +DPHA+AGALKSYLRELPEPLMT
Sbjct: 1072 SEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMT 1131
Query: 341 FELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPS 400
F+LYD+W++A++++E +LQAL C +LP N +N+RYL+KFL++L+E Q+VNKMTPS
Sbjct: 1132 FDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTPS 1191
Query: 401 NMAIVLGPNLLW-PQAEGNITEM--MTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNY 457
N+AIVLGPNLLW P+ EG+ ++ + S+Q+VG++E +IQ AD FPG+I FN++G +
Sbjct: 1192 NIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGLF 1251
Query: 458 G--------SPVHVNHNANYSSMPSPDMDPADRRQPEQARRP 491
S + +++P+P PA P A P
Sbjct: 1252 SAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAP 1293
>emb|CAB42896.1| (Z83844) dJ37E16.2 (SH3-domain binding protein 1) [Homo sapiens]
Length = 616
Score = 331 bits (839), Expect = 2e-89
Identities = 185/437 (42%), Positives = 262/437 (59%), Gaps = 30/437 (6%)
Query: 85 LGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAK 144
L D+ +GK L++ +++LA+ L FE+ +ERDV++PL L+E E+P I K +K L K
Sbjct: 8 LDPDSSMGKALEMSCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQK 67
Query: 145 LVLDMDSSRTRWQQTXXXXXXXX---------XXQPAGAKADALREEMEEAANRVEICRD 195
LV D ++ ++R Q K + L+EE EE +VE CRD
Sbjct: 68 LVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHSHTTMANKVETLKEEEEELKRKVEQCRD 127
Query: 196 QLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPS--- 252
+ AD+Y FV KE YANYF L+E+QA+YHR+SL+ L L +++ PS
Sbjct: 128 EYLADLYHFVTKEDSYANYFIRLLEIQADYHRRSLSSLDTALAELRENHGQADHSPSMTA 187
Query: 253 ------FGKPLEEHLTISGREIAFPIEACVTMLLECGMQEE-GLFRVAPXXXXXXXXXXX 305
+G L HL GREIA PIEACV MLL GM+EE GLFR+A
Sbjct: 188 THFPRVYGVSLATHLQELGREIALPIEACVMMLLSEGMKEEVGLFRLAAGASVLKRLKQT 247
Query: 306 XDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWN 365
++E+ +DPHA+AGALKSYLRELPEPLMTF+LYD+W++A++++E +LQAL
Sbjct: 248 MASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQE 307
Query: 366 ACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW-PQAEGNITEM-- 422
C +LP N +N+RYL+KFL++L+E Q+VNKMTPSN+AIVLGPNLLW P+ EG+ ++
Sbjct: 308 VCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDA 367
Query: 423 MTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYG--------SPVHVNHNANYSSMPS 474
+ S+Q+VG++E +IQ AD FPG+I FN++G + S + +++P+
Sbjct: 368 ASVSSIQVVGVVEALIQSADTLFPGDINFNVSGLFSAVTLQDTVSDRLASEELPSTAVPT 427
Query: 475 PDMDPADRRQPEQARRP 491
P PA P A P
Sbjct: 428 PATTPAPAPAPAPAPAP 444
>ref|NP_033190.1| SH3-domain binding protein 1 [Mus musculus]
sp|P55194|3BP1_MOUSE SH3-BINDING PROTEIN 3BP-1
pir||S56144 SH3 domain binding protein - mouse
emb|CAA61011.1| (X87671) SH3 domain binding protein [Mus musculus]
Length = 601
Score = 319 bits (809), Expect = 7e-86
Identities = 182/435 (41%), Positives = 258/435 (58%), Gaps = 24/435 (5%)
Query: 85 LGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAK 144
L D+ +GK L++ +++LA+ L FE+ +ERDV++ L+E E+P I K +K L K
Sbjct: 8 LDPDSSMGKALEMTCAIQNQLARILAEFEMTLERDVLQRSGRLSEEELPAILKHKKSLQK 67
Query: 145 LVLDMDSSRTRWQQTXXXXXXXXXXQPAGA---------KADALREEMEEAANRVEICRD 195
LV D ++ ++R Q A K + L+EE EE +VE C+D
Sbjct: 68 LVSDWNTLKSRLSQAAKNSGSNQGLGGASGSHTHTTTANKVEMLKEEEEELKKKVEQCKD 127
Query: 196 QLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPS--- 252
+ AD+Y F KE YANYF L+E+QA+YHRKSLT L L +++ P
Sbjct: 128 EYLADLYHFSTKEDSYANYFIHLLEIQADYHRKSLTSLDTALAELRDNHNQADHSPLTTA 187
Query: 253 ------FGKPLEEHLTISGREIAFPIEACVTMLLECGMQEE-GLFRVAPXXXXXXXXXXX 305
+G L HL GR+IA PIEACV +LL GMQEE GLFR+A
Sbjct: 188 APFSRVYGVSLRTHLQDLGRDIALPIEACVLLLLSEGMQEEEGLFRLAAGASVLKRLKQT 247
Query: 306 XDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWN 365
++E+ + PHA+AGALKSYLRELPEPLMT +LYD+W++A++++E +L+AL +
Sbjct: 248 MASDPHSLEEFCSGPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARLEALHD 307
Query: 366 ACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW-PQAEGNITEM-- 422
C +LP+ N NN+RYL+KFL+ L+E QDVNKMTPSN+AIVLGPNLLW P+ EG+ ++
Sbjct: 308 VCSRLPQENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDA 367
Query: 423 MTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYG--SPVHVNHNANYSSMPSPDMDPA 480
+ S+Q+VG++E +IQ+AD FPG+I FN++G + +P + S P PA
Sbjct: 368 ASVSSIQVVGVVEALIQNADTLFPGDINFNVSGIFPGLAPQEKVSSQQVSEELPPVTVPA 427
Query: 481 DRRQPEQARRPLSVA 495
P P S+A
Sbjct: 428 PATTPAPTLAPASMA 442
>gb|AAF55715.1| (AE003728) CG4755 gene product [Drosophila melanogaster]
Length = 740
Score = 221 bits (557), Expect = 3e-56
Identities = 148/470 (31%), Positives = 249/470 (52%), Gaps = 29/470 (6%)
Query: 1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60
MK+QF +++ +A + + R+ K++ +L +E++++ + +KL A L G G+
Sbjct: 1 MKRQFAKIK-IAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPA-LSGGGGS 58
Query: 61 ------EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFEL 114
E DKR+KK +AQ L E + L D L K+L CGE E +A+ +I EL
Sbjct: 59 GSGSSEEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESEL 118
Query: 115 QVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTXXXXXXXXXXQPAGA 174
+ E V+ L + + EI I ++++++ + + S + + +PA A
Sbjct: 119 ETEAKVVRRLKNILDKEIQEISTLKRNVSRTLQEYTSLKRSHE------AAIRLEEPA-A 171
Query: 175 KADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQ 234
K + ++ + EE ++E RD +A M +AKE + + + + Q YH ++L +
Sbjct: 172 KVNHIKSQQEECELKLEKERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVN 231
Query: 235 AVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAP 294
A L +I+ + EK FG L+EHLT + REI++ +E C LLE G++EEGL RV
Sbjct: 232 ASLARIQDTIQG-TEKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGC 290
Query: 295 XXXXXXXXXXXXDCCVVDVQ---EYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQAS 351
+ V +Y DPH I LK YLRELPEPL+T+ LY ++I+ +
Sbjct: 291 ASTKLRRMKHALEAQHVKTPLPLDYQ-DPHVIGSILKLYLRELPEPLLTYNLYKDFIRIA 349
Query: 352 NVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLL 411
+ ++ + KLPK N+ N+RYL +FLS + + +NKM+ N+AIV+ PN+L
Sbjct: 350 ERHSEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNML 409
Query: 412 WPQAEGN-------ITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNIT 454
WP+ + + I ++ ++ + I I+E +I D+FF GE+EF +T
Sbjct: 410 WPRIDKSSNAPADYIGQVNSSSAANI--IVELLISQWDYFFIGEVEFYLT 457
>gb|AAB22808.1| 3BP-1=Bcr/guanosine triphosphatase-activating protein-rho homolog
[mice, pre-B cells, Peptide, 339 aa]
Length = 339
Score = 178 bits (446), Expect = 3e-43
Identities = 90/180 (50%), Positives = 127/180 (70%), Gaps = 5/180 (2%)
Query: 321 HAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRY 380
HA+AGALKSYLRELPEPLMT +LYD+W++A++++E +L+AL + C +LP+ N NN+RY
Sbjct: 1 HAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARLEALHDVCSRLPQENFNNLRY 60
Query: 381 LIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW-PQAEGNITEM--MTTVSLQIVGIIEPI 437
L+KFL+ L+E QDVNKMTPSN+AIVLGPNLLW P+ EG+ ++ + S+Q+VG++E +
Sbjct: 61 LMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEAL 120
Query: 438 IQHADWFFPGEIEFNITGNYG--SPVHVNHNANYSSMPSPDMDPADRRQPEQARRPLSVA 495
IQ+AD FPG+I FN++G + +P + S P PA P P S+A
Sbjct: 121 IQNADTLFPGDINFNVSGIFPGLAPQEKVSSQQVSEELPPVTVPAPATTPAPTLAPASMA 180
>gb|AAF59636.1| (AC024755) contains similarity to TR:O75160 [Caenorhabditis
elegans]
Length = 604
Score = 152 bits (380), Expect = 1e-35
Identities = 105/386 (27%), Positives = 181/386 (46%), Gaps = 28/386 (7%)
Query: 56 GQQGAEADKRSKKLPLTTLAQCLMEGSAILG--DDTLLGKMLKLCGETEDKLAQELIHFE 113
G + DKR KK+ T+AQ L E S L + L +++ G E + E
Sbjct: 55 GFKEENVDKRKKKVEELTMAQNLREASVDLDYFQTSCLHRVINAYGTVLHAEVDEKVKLE 114
Query: 114 LQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTXXXXXXXXXXQPAG 173
+ +ER V E L +E E N+ K + L + D++ ++ ++
Sbjct: 115 MAMERRVYEELAPFSEYE-KNVNKLKDKLNLVSTDLEIAQKDLEKENSMTH--------- 164
Query: 174 AKADALREEMEEAANRVEICRDQLSADMY-SFVAKEIDYANYFQTLIEVQAEYHRKSLTL 232
+E ++ + E +D L D++ S V+KE + T + ++ +Y +K +
Sbjct: 165 ------QESLDAIQMKYEGMKDALVTDIFASSVSKEFQLNEHMLTSMNLKRDYFKKMYEM 218
Query: 233 LQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRV 292
+ +P+++ + +P FG PL+EHL+I I+ + C L + GM E G+FRV
Sbjct: 219 YEKAIPEVERMIATALPRPVFGVPLDEHLSIQKERISGVLTKCCDFLRQNGMNERGIFRV 278
Query: 293 APXXXXXXXXXXXXDCCVVDVQE--YSADPHAIAGALKSYLRELPEPLMTFELYDEWIQA 350
+ D D E Y+ DPHA+A LK+YLRELP+PL L +W++A
Sbjct: 279 SGNASKIKRIRAALDAGQFDADEKHYNNDPHAVASTLKAYLRELPDPLTMDSLQSDWVEA 338
Query: 351 SNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNL 410
N+ E +++ A+ +K+ + + N+ YL+KFL L ++ M SN+AIV P +
Sbjct: 339 INL-EGEERFSAIDRCLKKMTRGHRQNLIYLMKFLCDLEAKREETSMNASNLAIVFAPTM 397
Query: 411 LWPQAEG------NITEMMTTVSLQI 430
+G +TE M + ++I
Sbjct: 398 TGMIYDGMNTHGVKLTEFMISNGVRI 423
>emb|CAB75671.1| (AL157480) hypothetical protein [Homo sapiens]
Length = 346
Score = 143 bits (356), Expect = 9e-33
Identities = 72/164 (43%), Positives = 109/164 (65%), Gaps = 11/164 (6%)
Query: 339 MTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMT 398
MTF+LYD+W++A++++E +LQAL C +LP N +N+RYL+KFL++L+E Q+VNKMT
Sbjct: 5 MTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMT 64
Query: 399 PSNMAIVLGPNLLW-PQAEGNITEM--MTTVSLQIVGIIEPIIQHADWFFPGEIEFNITG 455
PSN+AIVLGPNLLW P+ EG+ ++ + S+Q+VG++E +IQ AD FPG+I FN++G
Sbjct: 65 PSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSG 124
Query: 456 NYG--------SPVHVNHNANYSSMPSPDMDPADRRQPEQARRP 491
+ S + +++P+P PA P A P
Sbjct: 125 LFSAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAP 168
>dbj|BAA96025.1| (AB040934) KIAA1501 protein [Homo sapiens]
Length = 735
Score = 101 bits (248), Expect = 4e-20
Identities = 58/201 (28%), Positives = 108/201 (52%), Gaps = 6/201 (2%)
Query: 252 SFGKPLEE-HLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCV 310
+FG LEE + + + AC ++ G++ G++RV +
Sbjct: 493 AFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGP 552
Query: 311 VDVQ---EYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNAC 367
D+ E D + I+ LKS+ R+LPEPL T + Y+++I+A+ +++ ++++ L
Sbjct: 553 GDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLI 612
Query: 368 EKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVS 427
LP + +++L+ L ++++ + NKM P N+A+V GP L+ +E N+T+M+T +
Sbjct: 613 RDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLV-RTSEDNMTDMVTHMP 671
Query: 428 LQIVGIIEPIIQHADWFFPGE 448
I+E +IQH+DWFF E
Sbjct: 672 -DRYKIVETLIQHSDWFFSDE 691
>dbj|BAA92662.1| (AB037845) KIAA1424 protein [Homo sapiens]
Length = 1286
Score = 100 bits (247), Expect = 6e-20
Identities = 64/218 (29%), Positives = 110/218 (50%), Gaps = 11/218 (5%)
Query: 264 SGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVDVQ---EYSADP 320
+ R I ++ C ++ E G++ G++RV + + D+ + D
Sbjct: 485 TNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDL 544
Query: 321 HAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRY 380
+ I+ LKS+ R+LPEPL T + Y ++I+A+ ++ +L+ L LP+ ++ +++
Sbjct: 545 NVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKF 604
Query: 381 LIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQH 440
L L ++E + NKM P N+AIV GP L+ +E N+T M+T + Q I+E +IQH
Sbjct: 605 LSAHLKTVAENSEKNKMEPRNLAIVFGPTLV-RTSEDNMTHMVTHMPDQ-YKIVETLIQH 662
Query: 441 ADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMD 478
DWFF E G V + S P P++D
Sbjct: 663 HDWFFTEE------GAEEPLTTVQEESTVDSQPVPNID 694
>gb|AAF80386.1|AF159851_1 (AF159851) Rho GAP p190-A [Homo sapiens]
Length = 1514
Score = 97.5 bits (239), Expect = 5e-19
Identities = 74/263 (28%), Positives = 117/263 (44%), Gaps = 15/263 (5%)
Query: 238 PQIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXX 297
P+ + W E FG PL +T + I IE C+ + G+ EG++RV+
Sbjct: 1234 PRPSITKATW-ESNYFGVPLTTVVTPE-KPIPIFIERCIEYIEATGLSTEGIYRVSGNKS 1291
Query: 298 XXXXXXXXXDCCV-VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQ 356
D +D+ E + +AGA+KS+ ELP+PL+ + + + ++A + ++
Sbjct: 1292 EIESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDR 1351
Query: 357 DKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAE 416
++KL AL +K PK NH +Y+I L+K+S VN MT N++I P L+ P
Sbjct: 1352 EQKLHALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFS 1411
Query: 417 GNITEMMTTVSLQIVGIIEPIIQHADWFF-------PGEIEFNITGNYGSPVHVNHNANY 469
T T + IIE IQ +FF P + S V +
Sbjct: 1412 ---TMDALTATRTYQTIIELFIQQCPFFFYNRPITEPPGARPSSPSAVASTVPFLTSTPV 1468
Query: 470 SSMPSPDMDPADRRQPEQARRPL 492
+S PSP P P+ +PL
Sbjct: 1469 TSQPSPPQSPPP--TPQSPMQPL 1489
>sp|P34588|YN54_CAEEL HYPOTHETICAL 80.8 KD PROTEIN ZC21.4 IN CHROMOSOME III
Length = 747
Score = 96.0 bits (235), Expect = 1e-18
Identities = 56/183 (30%), Positives = 99/183 (53%), Gaps = 11/183 (6%)
Query: 272 IEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVDVQEYSA---------DPHA 322
++ACV ++ GM G++R+ D + S D +
Sbjct: 108 VQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNV 167
Query: 323 IAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLI 382
++ LK +LR+LPEPL+T +LY +I A+ + +L L N KLP+ +++ +R+LI
Sbjct: 168 VSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLI 227
Query: 383 KFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHAD 442
LS+++++ DVNKM N+A++ GP+++ P ++ N+ M+T +S Q IIE +I +
Sbjct: 228 VHLSEITKHSDVNKMECRNLALMFGPSIVRP-SDDNMATMVTHMSDQ-CKIIETLIHYNL 285
Query: 443 WFF 445
W F
Sbjct: 286 WMF 288
>gb|AAA18934.1| (U02289) GTPase-activating protein [Caenorhabditis elegans]
Length = 1439
Score = 96.0 bits (235), Expect = 1e-18
Identities = 56/183 (30%), Positives = 99/183 (53%), Gaps = 11/183 (6%)
Query: 272 IEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVDVQEYSA---------DPHA 322
++ACV ++ GM G++R+ D + S D +
Sbjct: 800 VQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNV 859
Query: 323 IAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLI 382
++ LK +LR+LPEPL+T +LY +I A+ + +L L N KLP+ +++ +R+LI
Sbjct: 860 VSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLI 919
Query: 383 KFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHAD 442
LS+++++ DVNKM N+A++ GP+++ P ++ N+ M+T +S Q IIE +I +
Sbjct: 920 VHLSEITKHSDVNKMECRNLALMFGPSIVRP-SDDNMATMVTHMSDQ-CKIIETLIHYNL 977
Query: 443 WFF 445
W F
Sbjct: 978 WMF 980
>pir||S44876 ZC21.4 protein - Caenorhabditis elegans
gb|AAA28171.1| (L16685) homology with breakpoint cluster region protein; putative
[Caenorhabditis elegans]
Length = 733
Score = 96.0 bits (235), Expect = 1e-18
Identities = 56/183 (30%), Positives = 99/183 (53%), Gaps = 11/183 (6%)
Query: 272 IEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVDVQEYSA---------DPHA 322
++ACV ++ GM G++R+ D + S D +
Sbjct: 94 VQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNV 153
Query: 323 IAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLI 382
++ LK +LR+LPEPL+T +LY +I A+ + +L L N KLP+ +++ +R+LI
Sbjct: 154 VSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLPRPHYDTLRFLI 213
Query: 383 KFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHAD 442
LS+++++ DVNKM N+A++ GP+++ P ++ N+ M+T +S Q IIE +I +
Sbjct: 214 VHLSEITKHSDVNKMECRNLALMFGPSIVRP-SDDNMATMVTHMSDQ-CKIIETLIHYNL 271
Query: 443 WFF 445
W F
Sbjct: 272 WMF 274
>gb|AAF49953.1| (AE003542) CG6811 gene product [Drosophila melanogaster]
Length = 476
Score = 95.6 bits (234), Expect = 2e-18
Identities = 61/190 (32%), Positives = 99/190 (52%), Gaps = 4/190 (2%)
Query: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFP--IEACVTMLLECGMQE-EGLFRVAPXXX 297
+ QQ FG PL+ + S + P + CV L G+ + EG+FR +
Sbjct: 262 RQQQHKMATTHQFGVPLKFIVMNSPCLNSIPPIVRKCVDSLSITGVIDTEGIFRRSGNHS 321
Query: 298 XXXXXXXXXDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQD 357
+ DV S + H IAG LKS+LR+L EPL+TFELY++ + +++
Sbjct: 322 EIMALKERVNRGE-DVDLKSVNVHVIAGLLKSFLRDLAEPLLTFELYEDVTGFLDWPKEE 380
Query: 358 KKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEG 417
+ EKLP+ N+ +Y+++FL ++ + +D+NKMT SN+AIV GPN LW ++
Sbjct: 381 RSRNVTQLIREKLPEENYELFKYIVEFLVRVMDCEDLNKMTSSNLAIVFGPNFLWSRSTS 440
Query: 418 NITEMMTTVS 427
E + ++
Sbjct: 441 TSLEEIAPIN 450
>ref|NP_004136.1| myosin IXB [Homo sapiens]
gb|AAC50402.1| (U42391) myosin-IXb [Homo sapiens]
Length = 2022
Score = 95.2 bits (233), Expect = 2e-18
Identities = 59/182 (32%), Positives = 95/182 (51%), Gaps = 3/182 (1%)
Query: 259 EHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVDVQEYSA 318
+ LT + +E + + G+ EGL+R + V+ +
Sbjct: 1703 DSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENF 1762
Query: 319 DPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNI 378
HAI G LK +LRELPEPLMTF Y ++++A + E+ ++L A++ E LP+ANHN++
Sbjct: 1763 PIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSL 1822
Query: 379 RYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLL-WPQAEGNITEMMTTVSLQIVGIIEPI 437
LI L K++ +DVN+M+P +AI+ P LL P +T M L+I +E +
Sbjct: 1823 ERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDV--LKITTCVEML 1880
Query: 438 IQ 439
I+
Sbjct: 1881 IK 1882
>ref|NP_056557.1| myosin IXb [Mus musculus]
gb|AAF00118.1|AF143683_1 (AF143683) unconventional myosin 9bc [Mus musculus]
Length = 1961
Score = 94.4 bits (231), Expect = 4e-18
Identities = 66/218 (30%), Positives = 111/218 (50%), Gaps = 9/218 (4%)
Query: 226 HRKSLTLLQAVLPQI-KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGM 284
H+K + +Q+ + + E E FG ++ LT + +E + + G+
Sbjct: 1628 HKKCVHKIQSYCSYTGRRKSELGAEPGHFGVCVDS-LTSDKASVPIVLEKLLEHVEMHGL 1686
Query: 285 QEEGLFRV--APXXXXXXXXXXXXDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFE 342
EGL+R A D V ++++ HAI G LK +LRELPEPLMTF
Sbjct: 1687 YTEGLYRKSGAANRTRELRQALQTDPAAVKLEDFPI--HAITGVLKQWLRELPEPLMTFA 1744
Query: 343 LYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNM 402
Y ++++A + E+ ++L A++ + LP+ANH ++ LI L K++ +DVN+M+P +
Sbjct: 1745 QYGDFLRAVELPEKQEQLSAIYAVLDHLPEANHTSLERLIFHLVKVALLEDVNRMSPGAL 1804
Query: 403 AIVLGPNLL-WPQAEGNITEMMTTVSLQIVGIIEPIIQ 439
AI+ P LL P +T M L+I +E +I+
Sbjct: 1805 AIIFAPCLLRCPDNSDPLTSMKDV--LKITTCVEMLIK 1840
>ref|NP_033836.1| rho GTPase activating protein 5 [Mus musculus]
gb|AAD12768.1| (U67160) p190-B [Mus musculus]
Length = 1501
Score = 94.4 bits (231), Expect = 4e-18
Identities = 58/203 (28%), Positives = 106/203 (51%), Gaps = 6/203 (2%)
Query: 249 EKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDC 308
E FG PL++ +T + I +E CV + + G+ EGL+RV+ D
Sbjct: 1255 ESNYFGMPLQDLVTAE-KPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQ 1313
Query: 309 CV-VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNAC 367
+++ +A+AGALK++ +LP+PL+ + L+ E ++A+ + ++ ++ AL
Sbjct: 1314 DHNINLASMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERFHALKEIV 1373
Query: 368 EKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVS 427
+K N++ RY+I L+++S+ +N MT N++I G L+ P E E ++T
Sbjct: 1374 KKFHPVNYDVFRYVITHLNRVSQQNKINLMTADNLSICFGQPLMRPDFENR--EFLSTTK 1431
Query: 428 LQIVGIIEPIIQHADWFF-PGEI 449
+ ++E IQ +FF GEI
Sbjct: 1432 IH-QSVVETFIQQCQFFFYNGEI 1453
>ref|NP_037116.1| unconventional myosin from rat 3 [Rattus norvegicus]
pir||S54307 myosin heavy chain - rat
emb|CAA54700.1| (X77609) myosin heavy chain [Rattus norvegicus]
Length = 1980
Score = 94.0 bits (230), Expect = 6e-18
Identities = 66/218 (30%), Positives = 111/218 (50%), Gaps = 9/218 (4%)
Query: 226 HRKSLTLLQAVLPQI-KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGM 284
H+K + +Q+ + + E E FG ++ LT + +E + + G+
Sbjct: 1630 HKKCVHKIQSYCSYTGRRKSELGAEPGHFGVCVDS-LTSDKASVPIVLEKLLEHVEMHGL 1688
Query: 285 QEEGLFRV--APXXXXXXXXXXXXDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFE 342
EGL+R A D V ++++ HAI G LK +LRELPEPLMTF
Sbjct: 1689 YTEGLYRKSGAANRTRELRQALQTDPATVKLEDFPI--HAITGVLKQWLRELPEPLMTFA 1746
Query: 343 LYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNM 402
Y ++++A + E+ ++L A++ + LP+ANH ++ LI L K++ +DVN+M+P +
Sbjct: 1747 QYGDFLRAVELPEKQEQLAAIYAVLDHLPEANHTSLERLIFHLVKVALLEDVNRMSPGAL 1806
Query: 403 AIVLGPNLL-WPQAEGNITEMMTTVSLQIVGIIEPIIQ 439
AI+ P LL P +T M L+I +E +I+
Sbjct: 1807 AIIFAPCLLRCPDNSDPLTSMKDV--LKITTCVEMLIK 1842
>gb|AAF00119.1|AF143684_1 (AF143684) unconventional myosin IXb [Homo sapiens]
Length = 396
Score = 92.8 bits (227), Expect = 1e-17
Identities = 50/120 (41%), Positives = 76/120 (62%), Gaps = 3/120 (2%)
Query: 321 HAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRY 380
HAI G LK +LRELPEPLMTF Y ++++A + E+ ++L A++ E LP+ANHN++
Sbjct: 3 HAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLER 62
Query: 381 LIKFLSKLSEYQDVNKMTPSNMAIVLGPNLL-WPQAEGNITEMMTTVSLQIVGIIEPIIQ 439
LI L K++ +DVN+M+P +AI+ P LL P +T M L+I +E +I+
Sbjct: 63 LIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDV--LKITTCVEMLIK 120
>dbj|BAA86518.1| (AB033030) KIAA1204 protein [Homo sapiens]
Length = 1445
Score = 90.9 bits (222), Expect = 5e-17
Identities = 60/210 (28%), Positives = 106/210 (49%), Gaps = 13/210 (6%)
Query: 252 SFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFR---VAPXXXXXXXXXXXXDC 308
+FG L E+L SG+++ + +++C + G+ + G++R V C
Sbjct: 19 AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEFGSDQC 77
Query: 309 CVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACE 368
+ + Y D H + K Y RELP PL+T+ELY+++ +A + ++ +L + N +
Sbjct: 78 PDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQ 137
Query: 369 KLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWP---QAEG-NITEMMT 424
+LP +++ + YLI+ L+ ++ + M N+A+V PNLL +A G N
Sbjct: 138 ELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFL 197
Query: 425 TVSLQIVGIIEPIIQHADWFF----PGEIE 450
V +Q V +IE I+ H D F PG +E
Sbjct: 198 AVRVQQV-VIEFILNHVDQIFNNGAPGSLE 226
>ref|NP_002538.1| oligophrenin 1, Rho-GTPase acivating protein [Homo sapiens]
emb|CAA04579.1| (AJ001189) oligophrenin 1 [Homo sapiens]
emb|CAB96181.1| (AJ248245) oligophrenin-1 [Homo sapiens]
Length = 802
Score = 90.9 bits (222), Expect = 5e-17
Identities = 60/220 (27%), Positives = 106/220 (47%), Gaps = 13/220 (5%)
Query: 241 KAQQEAWVE-----KPSFGKPLEEHLTISGREIAFP-IEACVTMLLECGMQEEGLFRVAP 294
+A + W+E +P + P+ + + E+ F + C+ ++ G++ EGL+R
Sbjct: 353 EANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVG 412
Query: 295 XXXXXXXXXXXX--DCCVVDVQEYSAD--PHAIAGALKSYLRELPEPLMTFELYDEWIQA 350
C DV +++D I +LK YLR L EP+MT+ L+ E + A
Sbjct: 413 SNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSA 472
Query: 351 SNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNL 410
+ D +L A+ + KLP+ N + LI+ L + E+ N MTPSNM ++ GP L
Sbjct: 473 AKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTL 532
Query: 411 LWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIE 450
+ +A+ + M + Q + ++E +I+H + G E
Sbjct: 533 M--RAQEDTVAAMMNIKFQNI-VVEILIEHFGKIYLGPPE 569
>gb|AAF53844.1| (AE003664) CdGAPr gene product [Drosophila melanogaster]
Length = 1817
Score = 90.5 bits (221), Expect = 6e-17
Identities = 63/199 (31%), Positives = 102/199 (50%), Gaps = 8/199 (4%)
Query: 253 FGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDC-CVV 311
F L EHL SG++I + +C + G+ + G++R++ D V
Sbjct: 422 FNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVID-GIYRLSGITSNIQRLRRAFDEERVP 480
Query: 312 DV--QEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQ--EQDKKLQALWNAC 367
D+ E D HA++ LK Y RELP PL T++LYD +++A V+ E D++L+ +
Sbjct: 481 DLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETV 540
Query: 368 EKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLL-WPQAEGNITEMMTTV 426
KLP ++ ++YL + L K+S++ MT N+AIV PNLL P E + V
Sbjct: 541 LKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGV 600
Query: 427 SLQIVGIIEPIIQHADWFF 445
+Q V + E +I++ F
Sbjct: 601 GVQAV-VTEYLIRNCHNIF 618
>gb|AAF44627.1| (AF218776) GTPase activating protein [Drosophila melanogaster]
Length = 1843
Score = 90.5 bits (221), Expect = 6e-17
Identities = 63/199 (31%), Positives = 102/199 (50%), Gaps = 8/199 (4%)
Query: 253 FGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDC-CVV 311
F L EHL SG++I + +C + G+ + G++R++ D V
Sbjct: 422 FNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVID-GIYRLSGITSNIQRLRRAFDEERVP 480
Query: 312 DV--QEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQ--EQDKKLQALWNAC 367
D+ E D HA++ LK Y RELP PL T++LYD +++A V+ E D++L+ +
Sbjct: 481 DLGNPEMKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETV 540
Query: 368 EKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLL-WPQAEGNITEMMTTV 426
KLP ++ ++YL + L K+S++ MT N+AIV PNLL P E + V
Sbjct: 541 LKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLLRSPALESGGVAALRGV 600
Query: 427 SLQIVGIIEPIIQHADWFF 445
+Q V + E +I++ F
Sbjct: 601 GVQAV-VTEYLIRNCHNIF 618
>pir||T27959 hypothetical protein ZK669.1b - Caenorhabditis elegans
emb|CAA85469.1| (Z37093) alternative splicing in ZK669.1a, contains similarity to
Pfam domain: PF00620 (RhoGAP domain), Score=149.9,
E-value=1.5e-41, N=1~cDNA EST yk36g1.5 comes from this
gene [Caenorhabditis elegans]
emb|CAA86848.1| (Z46812) alternative splicing in ZK669.1a, contains similarity to
Pfam domain: PF00620 (RhoGAP domain), Score=149.9,
E-value=1.5e-41, N=1~cDNA EST yk36g1.5 comes from this
gene [Caenorhabditis elegans]
Length = 634
Score = 90.1 bits (220), Expect = 8e-17
Identities = 57/212 (26%), Positives = 107/212 (49%), Gaps = 17/212 (8%)
Query: 214 YFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPS--FGKPLEEHLTISGREIAFP 271
Y I+ ++H+ +Q Q+ Q V++ + FG PL+ L R I
Sbjct: 140 YTVQCIDCGGQWHKACFPRIQ----QVCGQAAKLVDRRTSIFGVPLKGLLEHQNRHIPLI 195
Query: 272 IEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVDVQEY--SADPHAIAGALKS 329
IE + L G++ +G++R + D + + +P +A +K
Sbjct: 196 IEKSIDQLQRRGLRAKGIYRTCGVKSKIEEICNAFERSSSDDEVCLDNENPMNLASVVKL 255
Query: 330 YLRELPEPLMTFELYDEWI---------QASNVQEQDKKLQALWNACEKLPKANHNNIRY 380
YLR+LPEPL+TFELYD+++ QAS ++++++ L KLP N+ +++
Sbjct: 256 YLRKLPEPLLTFELYDDFVRLGTECCSAQASGSNCEEERVEQLRQLARKLPVHNYETLKF 315
Query: 381 LIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW 412
++ L+++S + +VN M+ SN++ V+ P+L+W
Sbjct: 316 IMLHLNRVSWFHEVNLMSTSNLSTVIAPSLIW 347
>pir||T27958 hypothetical protein ZK669.1a - Caenorhabditis elegans
emb|CAA85468.1| (Z37093) alternative splicing in ZK669.1b, contains similarity to
Pfam domain: PF00620 (RhoGAP domain), Score=149.9,
E-value=1.5e-41, N=1~cDNA EST yk39b7.5 comes from this
gene~cDNA EST yk50c2.5 comes from this gene~cDNA EST
yk39b7.3 comes from this ge>
emb|CAA86847.1| (Z46812) alternative splicing in ZK669.1b, contains similarity to
Pfam domain: PF00620 (RhoGAP domain), Score=149.9,
E-value=1.5e-41, N=1~cDNA EST yk39b7.5 comes from this
gene~cDNA EST yk50c2.5 comes from this gene~cDNA EST
yk39b7.3 comes from this ge>
Length = 863
Score = 90.1 bits (220), Expect = 8e-17
Identities = 57/212 (26%), Positives = 107/212 (49%), Gaps = 17/212 (8%)
Query: 214 YFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPS--FGKPLEEHLTISGREIAFP 271
Y I+ ++H+ +Q Q+ Q V++ + FG PL+ L R I
Sbjct: 369 YTVQCIDCGGQWHKACFPRIQ----QVCGQAAKLVDRRTSIFGVPLKGLLEHQNRHIPLI 424
Query: 272 IEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVDVQEY--SADPHAIAGALKS 329
IE + L G++ +G++R + D + + +P +A +K
Sbjct: 425 IEKSIDQLQRRGLRAKGIYRTCGVKSKIEEICNAFERSSSDDEVCLDNENPMNLASVVKL 484
Query: 330 YLRELPEPLMTFELYDEWI---------QASNVQEQDKKLQALWNACEKLPKANHNNIRY 380
YLR+LPEPL+TFELYD+++ QAS ++++++ L KLP N+ +++
Sbjct: 485 YLRKLPEPLLTFELYDDFVRLGTECCSAQASGSNCEEERVEQLRQLARKLPVHNYETLKF 544
Query: 381 LIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW 412
++ L+++S + +VN M+ SN++ V+ P+L+W
Sbjct: 545 IMLHLNRVSWFHEVNLMSTSNLSTVIAPSLIW 576
>pir||A38218 GAP-associated protein p190 - rat
Length = 1493
Score = 89.7 bits (219), Expect = 1e-16
Identities = 71/257 (27%), Positives = 117/257 (44%), Gaps = 8/257 (3%)
Query: 238 PQIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXX 297
P+ + W E FG PL +T + I IE C+ + G+ EG++RV+
Sbjct: 1213 PRPSITKATW-ESNYFGVPLTTVVTPE-KPIPIFIERCIEYIEATGLSTEGIYRVSGNKS 1270
Query: 298 XXXXXXXXXDCCV-VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQ 356
D +D+ E + +AGA+KS+ EL + L+ + + + ++A + ++
Sbjct: 1271 EMESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELRDRLVRYSMQIDLVEAHKINDR 1330
Query: 357 DKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAE 416
++KL AL +K PK NH +Y+I L+++S VN MT N++I P L+ P
Sbjct: 1331 EQKLHALKEVLKKFPKENHEVFKYVISHLNRVSHNNKVNLMTSENLSICFWPTLMRPDF- 1389
Query: 417 GNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPD 476
++ + T S Q IIE IQ +FF G +P+ H + SS
Sbjct: 1390 SSMDALTATRSYQT--IIELFIQQCPFFFYNRPISEPPGAALAPLQPWHPLSPSS--PLH 1445
Query: 477 MDPADRRQPEQARRPLS 493
+ P P +PLS
Sbjct: 1446 LLPVSHHLPSHLLQPLS 1462
>ref|NP_064656.1| Cdc42 GTPase-activating protein [Mus musculus]
gb|AAD38043.1|AF151363_1 (AF151363) Cdc42 GTPase-activating protein [Mus musculus]
Length = 820
Score = 89.3 bits (218), Expect = 1e-16
Identities = 57/203 (28%), Positives = 103/203 (50%), Gaps = 9/203 (4%)
Query: 252 SFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXX---XXDC 308
+FG L E+L SG+++ + +++C + G+ + G++R++ C
Sbjct: 18 AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYRLSGITSNIQRLRQEFGSDQC 76
Query: 309 CVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACE 368
+ + Y D H + K Y RELP PL+T+ELY+++ +A + + ++ +L + N
Sbjct: 77 PDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHRPEEGQLARIQNVIL 136
Query: 369 KLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLL-WPQAEGNITE---MMT 424
+LP ++ + YLI+ L+ ++ + M N+A+V PNLL + E I
Sbjct: 137 ELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKKIEATICNGDAAFL 196
Query: 425 TVSLQIVGIIEPIIQHADWFFPG 447
V +Q V +IE I+ HAD F G
Sbjct: 197 AVRVQQV-VIEFILNHADQIFNG 218
>gb|AAB84002.1| (AF027687) GTPase activating protein homolog [Cochliobolus
heterostrophus]
Length = 714
Score = 88.9 bits (217), Expect = 2e-16
Identities = 47/192 (24%), Positives = 96/192 (49%), Gaps = 6/192 (3%)
Query: 251 PSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCV 310
P FG LEE G + + C+ + G++ EG++R+ +
Sbjct: 527 PIFGVTLEELFRRDGSPVPIIVYQCIQAVDLYGLEVEGIYRIPGTSSHIQQMKA-----L 581
Query: 311 VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKL 370
D + + D +++AG LK + RELP+PL+T E Y ++I+A+ + + + ++ L
Sbjct: 582 FDSESFQHDVNSVAGLLKQFFRELPDPLLTREFYGKYIEAARIDDDTMRRDSMHALINAL 641
Query: 371 PKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQI 430
P N+ +R L L ++ + ++N+M+ +N+AI P+++ P N+ + + I
Sbjct: 642 PDPNYATLRALALHLHRVQQSSEINRMSTANLAICWAPSIMGPHKGNNMADAGLQARV-I 700
Query: 431 VGIIEPIIQHAD 442
+ I++ ++Q D
Sbjct: 701 ITILDNVLQIFD 712
>gb|AAB82943.1| (AF029913) GTPase activating protein homolog [Cochliobolus
heterostrophus]
Length = 714
Score = 88.9 bits (217), Expect = 2e-16
Identities = 47/192 (24%), Positives = 96/192 (49%), Gaps = 6/192 (3%)
Query: 251 PSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCV 310
P FG LEE G + + C+ + G++ EG++R+ +
Sbjct: 527 PIFGVTLEELFRRDGSPVPIIVYQCIQAVDLYGLEVEGIYRIPGTSSHIQQMKA-----L 581
Query: 311 VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKL 370
D + + D +++AG LK + RELP+PL+T E Y ++I+A+ + + + ++ L
Sbjct: 582 FDSESFQHDVNSVAGLLKQFFRELPDPLLTREFYGKYIEAARIDDDTMRRDSMHALINAL 641
Query: 371 PKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQI 430
P N+ +R L L ++ + ++N+M+ +N+AI P+++ P N+ + + I
Sbjct: 642 PDPNYATLRALALHLHRVQQSSEINRMSTANLAICWAPSIMGPHKGNNMADAGLQARV-I 700
Query: 431 VGIIEPIIQHAD 442
+ I++ ++Q D
Sbjct: 701 ITILDNVLQIFD 712
>pdb|1TX4|A Chain A, RhoRHOGAPGDP(DOT)ALF4 COMPLEX
Length = 198
Score = 88.5 bits (216), Expect = 2e-16
Identities = 45/102 (44%), Positives = 67/102 (65%), Gaps = 2/102 (1%)
Query: 311 VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKL 370
VD +Y+A H A LK++LRELPEPL+TF+LY + N+ E +++ A + L
Sbjct: 70 VDFDQYNA-LHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDES-QRVPATLQVLQTL 127
Query: 371 PKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW 412
P+ N+ +R+L FL ++S + D NKMT +N+A+V GPNLLW
Sbjct: 128 PEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLW 169
>ref|NP_001164.1| Rho GTPase activating protein 5; RhoGAP5; p190-B [Homo sapiens]
gb|AAA95963.1| (U17032) p190-B [Homo sapiens]
Length = 1499
Score = 88.5 bits (216), Expect = 2e-16
Identities = 56/203 (27%), Positives = 105/203 (51%), Gaps = 6/203 (2%)
Query: 249 EKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXX-D 307
E FG PL++ +T + I +E CV + + G+ E L+RV+
Sbjct: 1253 ESNYFGMPLQDLVTAE-KPIPLFVEKCVEFIEDTGLCTERLYRVSGNKTDQENIQKQFVQ 1311
Query: 308 CCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNAC 367
+++ +A+AGALK++ +LP+PL+ + L+ E ++A+ + ++ ++L AL
Sbjct: 1312 DHNINLVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIV 1371
Query: 368 EKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVS 427
+K N++ RY+I L+++S+ +N MT N++I G L+ P + E ++T
Sbjct: 1372 KKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFGQPLMRPDLKS--MEFLSTTK 1429
Query: 428 LQIVGIIEPIIQHADWFF-PGEI 449
+ ++E IQ +FF GEI
Sbjct: 1430 IH-QSVVETFIQQCQFFFYNGEI 1451
>pdb|1GRN|B Chain B, Crystal Structure Of The Cdc42CDC42GAPALF3 COMPLEX
Length = 203
Score = 87.8 bits (214), Expect = 4e-16
Identities = 44/102 (43%), Positives = 67/102 (65%), Gaps = 2/102 (1%)
Query: 311 VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKL 370
VD +Y+ + H A LK++LRELPEPL+TF+LY + N+ E +++ A + L
Sbjct: 67 VDFDQYN-ELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDES-QRVPATLQVLQTL 124
Query: 371 PKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW 412
P+ N+ +R+L FL ++S + D NKMT +N+A+V GPNLLW
Sbjct: 125 PEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLW 166
>pdb|2NGR|B Chain B, Transition State Complex For Gtp Hydrolysis By Cdc42:
Comparisons Of The High Resolution Structures For Cdc42
Bound To The Active And Catalytically Compromised Forms
Of The Cdc42-Gap
Length = 234
Score = 87.8 bits (214), Expect = 4e-16
Identities = 44/102 (43%), Positives = 67/102 (65%), Gaps = 2/102 (1%)
Query: 311 VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKL 370
VD +Y+ + H A LK++LRELPEPL+TF+LY + N+ E +++ A + L
Sbjct: 98 VDFDQYN-ELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDES-QRVPATLQVLQTL 155
Query: 371 PKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW 412
P+ N+ +R+L FL ++S + D NKMT +N+A+V GPNLLW
Sbjct: 156 PEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLW 197
>pdb|1AM4|A Chain A, Complex Between Cdc42hs.Gmppnp And P50 Rhogap (H. Sapiens)
pdb|1AM4|B Chain B, Complex Between Cdc42hs.Gmppnp And P50 Rhogap (H. Sapiens)
pdb|1AM4|C Chain C, Complex Between Cdc42hs.Gmppnp And P50 Rhogap (H. Sapiens)
Length = 199
Score = 87.8 bits (214), Expect = 4e-16
Identities = 44/102 (43%), Positives = 67/102 (65%), Gaps = 2/102 (1%)
Query: 311 VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKL 370
VD +Y+ + H A LK++LRELPEPL+TF+LY + N+ E +++ A + L
Sbjct: 71 VDFDQYN-ELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDES-QRVPATLQVLQTL 128
Query: 371 PKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW 412
P+ N+ +R+L FL ++S + D NKMT +N+A+V GPNLLW
Sbjct: 129 PEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLW 170
>pdb|1RGP| Gtpase-Activation Domain From Rhogap
Length = 242
Score = 87.8 bits (214), Expect = 4e-16
Identities = 44/102 (43%), Positives = 67/102 (65%), Gaps = 2/102 (1%)
Query: 311 VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKL 370
VD +Y+ + H A LK++LRELPEPL+TF+LY + N+ E +++ A + L
Sbjct: 106 VDFDQYN-ELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDES-QRVPATLQVLQTL 163
Query: 371 PKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW 412
P+ N+ +R+L FL ++S + D NKMT +N+A+V GPNLLW
Sbjct: 164 PEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLW 205
>pir||A49678 GTPase-activating protein rhoGAP - human (fragment)
gb|AAA16142.1| (U02570) CDC42 GTPase-activating protein [Homo sapiens]
Length = 462
Score = 87.8 bits (214), Expect = 4e-16
Identities = 44/102 (43%), Positives = 67/102 (65%), Gaps = 2/102 (1%)
Query: 311 VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKL 370
VD +Y+ + H A LK++LRELPEPL+TF+LY + N+ E +++ A + L
Sbjct: 326 VDFDQYN-ELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDES-QRVPATLQVLQTL 383
Query: 371 PKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW 412
P+ N+ +R+L FL ++S + D NKMT +N+A+V GPNLLW
Sbjct: 384 PEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLW 425
>ref|NP_004299.1| Rho GTPase activating protein 1; RhoGAP; p50rhoGAP; CDC42
GTPase-activating protein [Homo sapiens]
sp|Q07960|RHG1_HUMAN RHO-GTPASE-ACTIVATING PROTEIN 1 (GTPASE-ACTIVATING PROTEIN RHOGAP)
(RHO-RELATED SMALL GTPASE PROTEIN ACTIVATOR) (CDC42
GTPASE-ACTIVATING PROTEIN) (P50-RHOGAP)
emb|CAA80560.1| (Z23024) rhoGAP protein [Homo sapiens]
Length = 439
Score = 87.8 bits (214), Expect = 4e-16
Identities = 44/102 (43%), Positives = 67/102 (65%), Gaps = 2/102 (1%)
Query: 311 VDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKL 370
VD +Y+ + H A LK++LRELPEPL+TF+LY + N+ E +++ A + L
Sbjct: 303 VDFDQYN-ELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDES-QRVPATLQVLQTL 360
Query: 371 PKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLW 412
P+ N+ +R+L FL ++S + D NKMT +N+A+V GPNLLW
Sbjct: 361 PEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLW 402
>gb|AAF22154.1|AF133093_9 (AF133093) protein with characteristics of a rhoGAP [Mus musculus]
Length = 955
Score = 87.0 bits (212), Expect = 7e-16
Identities = 55/201 (27%), Positives = 97/201 (47%), Gaps = 25/201 (12%)
Query: 253 FGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVD 312
FG LE+ + SG+ + +E+C+ + G+Q EG+FRV+ + D
Sbjct: 516 FGGDLEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQARISE--------IRD 567
Query: 313 VQEYSADP----------HAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQA 362
E DP ++AG LK Y R L PL ++++E + ++ ++ ++++
Sbjct: 568 AFERGEDPLEKGCTVHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVEP 627
Query: 363 LWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQA------- 415
+ + KLP+ +RYL FL+ L++Y D N M N+A+ GP LL A
Sbjct: 628 VSHLLFKLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLLPVPAGQDPVAL 687
Query: 416 EGNITEMMTTVSLQIVGIIEP 436
+G + +++ T+ LQ I P
Sbjct: 688 QGRVNQLVQTLILQPARIFPP 708
>gb|AAF46047.1| (AE003434) CG3208 gene product [Drosophila melanogaster]
Length = 494
Score = 86.6 bits (211), Expect = 9e-16
Identities = 53/165 (32%), Positives = 89/165 (53%), Gaps = 4/165 (2%)
Query: 267 EIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCC--VVDVQEYS-ADPHAI 323
+I F + CV + GM +EG++RV+ D D+ E + + + I
Sbjct: 317 QIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVI 376
Query: 324 AGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIK 383
AG LK YLR LP PL+TF+ Y ++ A +Q ++ Q + A +LP A+H+ ++Y+++
Sbjct: 377 AGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLE 436
Query: 384 FLSKLSEYQDVNKMTPSNMAIVLGPNLL-WPQAEGNITEMMTTVS 427
L +++ + VNKM N+A V P L+ PQ N+TE + +S
Sbjct: 437 HLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFMLS 481
>pir||T39954 probable gtpase activating protein homolog - fission yeast
(Schizosaccharomyces pombe)
emb|CAA22624.1| (AL035065) putative gtpase activating protein homolog
[Schizosaccharomyces pombe]
Length = 695
Score = 86.6 bits (211), Expect = 9e-16
Identities = 51/182 (28%), Positives = 89/182 (48%), Gaps = 4/182 (2%)
Query: 253 FGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXD----C 308
FG L+ + I + C + + G+ +G++RV +
Sbjct: 504 FGARLDAIILREHSNIPNIVMQCTSQVENFGLNLQGIYRVPSSSARVNMLRSQFENNPLL 563
Query: 309 CVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACE 368
+ ++Y D HA+A LK + REL EPL+ ++I A NV+++ ++ A+ A
Sbjct: 564 QLHTPEDYENDVHAVADLLKIFFRELREPLIPDNHQRDFIDAGNVEDESRRRDAVHRAIN 623
Query: 369 KLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSL 428
LP AN++ IR+L L+K+ E DVNKM+ +N+AI+ GP ++ I+ T+ +
Sbjct: 624 DLPDANYSTIRHLTIHLAKIKENSDVNKMSTNNLAIIWGPTIIKQATIPEISSFSRTIEI 683
Query: 429 QI 430
I
Sbjct: 684 LI 685
>pir||T18289 racGAP protein - slime mold (Dictyostelium discoideum)
emb|CAA71241.1| (Y10159) racGAP [Dictyostelium discoideum]
Length = 1335
Score = 86.2 bits (210), Expect = 1e-15
Identities = 50/134 (37%), Positives = 72/134 (53%), Gaps = 1/134 (0%)
Query: 284 MQEEGLFRVAPXXXXXXXXXXXXDCCVVDVQEY-SADPHAIAGALKSYLRELPEPLMTFE 342
+ EEG+FR+ D D+ ++ S+D H++AG LK YLRELPEPL +
Sbjct: 44 VNEEGIFRIPGNGVTIQEIKKSFDEGKGDLSKFNSSDIHSVAGVLKLYLRELPEPLFIWR 103
Query: 343 LYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNM 402
Y +I+ + ++ L C LPK N + + L+ FL+K+S VNKMT N+
Sbjct: 104 YYSTFIKVIKNPDHLQRALHLRMLCYGLPKVNRDLVLSLMVFLNKISLNNRVNKMTSQNL 163
Query: 403 AIVLGPNLLWPQAE 416
A V PN+L PQ E
Sbjct: 164 ATVFAPNILRPQKE 177
>pir||T20802 hypothetical protein F12F6.5 - Caenorhabditis elegans
emb|CAA97790.1| (Z73425) Similarity to Human chimaerin (SW:CHIN_HUMAN), contains
similarity to Pfam domain: PF00620 (RhoGAP domain),
Score=155.8, E-value=2.4e-43, N=1~cDNA EST yk13f2.3
comes from this gene~cDNA EST yk4f9.3 comes from this
gene~cDNA EST yk4f9.5 comes f>
Length = 1059
Score = 85.4 bits (208), Expect = 2e-15
Identities = 58/217 (26%), Positives = 104/217 (47%), Gaps = 8/217 (3%)
Query: 253 FGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVD 312
FG L+E++ +G EI +++ + L ++ +GLFRV+ + D
Sbjct: 525 FGGSLDEYVEATGEEIPLLVQSAIAYLSRYSLRNQGLFRVSGSQSEINRFREAYERGE-D 583
Query: 313 VQEY---SADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEK 369
+ +Y +D ++ AG LK Y REL EP+ +++++ + + + ++ K
Sbjct: 584 LFQYLDDGSDANSAAGVLKLYFRELREPIFPIFMFEQFCDCAKSESPTEFVRRARELVSK 643
Query: 370 LPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQ 429
LP ++ +R+L FLS L E+ D N M P N+AI GP LL P EG +
Sbjct: 644 LPVSHVLLLRFLFAFLSHLCEFADENMMEPHNLAICFGPTLL-PIPEG---KDQVFYHNY 699
Query: 430 IVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHN 466
+ ++ +I HAD FP ++ + Y +++ N
Sbjct: 700 VNELVRNLIIHADDVFPRDLAGPVYDKYAMQRYMDGN 736
>sp|P98171|RHG4_HUMAN RHO-GTPASE-ACTIVATING PROTEIN 4 (RHO-GAP HEMATOPOIETIC PROTEIN C1)
(P115) (KIAA0131)
pir||I38100 p115 - human
emb|CAA55394.1| (X78817) p115 [Homo sapiens]
Length = 946
Score = 85.0 bits (207), Expect = 3e-15
Identities = 54/202 (26%), Positives = 97/202 (47%), Gaps = 25/202 (12%)
Query: 253 FGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVD 312
FG +E+ + SG+ + +E+C+ + G+Q EG+FRV+ + D
Sbjct: 505 FGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSE--------IRD 556
Query: 313 VQEYSADP----------HAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQA 362
E DP ++AG LK Y R L PL +L+ E + +S +++ ++++
Sbjct: 557 AFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEDTAERVEH 616
Query: 363 LWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQA------- 415
+ +LP +RYL FL+ L++Y D N M P N+A+ GP LL A
Sbjct: 617 VSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVAL 676
Query: 416 EGNITEMMTTVSLQIVGIIEPI 437
+G + +++ T+ +Q + P+
Sbjct: 677 QGRVNQLVQTLIVQPDRVFPPL 698
>emb|CAB70766.1| (AL137485) hypothetical protein [Homo sapiens]
Length = 316
Score = 84.7 bits (206), Expect = 4e-15
Identities = 59/211 (27%), Positives = 106/211 (49%), Gaps = 4/211 (1%)
Query: 227 RKSLTLLQAVLPQIKAQQE-AWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQ 285
+K+L P ++A +E +++ FG L + ++ C+ + E G+
Sbjct: 97 KKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLD 156
Query: 286 EEGLFRVAPXXXXXXXXXXXXDCCV-VDVQEYS-ADPHAIAGALKSYLRELPEPLMTFEL 343
+G++RV+ + +D+ + D H I GALK + RELPEPL TF
Sbjct: 157 IDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNH 216
Query: 344 YDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMA 403
+++++ A QE +++ A+ + +LPK N + ++ L + L ++ E + N+MT ++A
Sbjct: 217 FNDFVNAIK-QEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIA 275
Query: 404 IVLGPNLLWPQAEGNITEMMTTVSLQIVGII 434
IV GP LL P+ E + T QIV +I
Sbjct: 276 IVFGPTLLKPEKETGNIAVHTVYQNQIVELI 306
>pir||B53764 beta2-chimerin, cerebellar - rat (fragment)
Length = 443
Score = 84.7 bits (206), Expect = 4e-15
Identities = 49/178 (27%), Positives = 92/178 (51%), Gaps = 7/178 (3%)
Query: 272 IEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDC----CVVDVQEYSADPHAIAGAL 327
++ C+ + G++ EGL+RV+ D + Y D + I GAL
Sbjct: 269 VDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANIYP-DINIITGAL 327
Query: 328 KSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSK 387
K Y R+LP P++T++ Y ++I+A+ + D++L+A+ LP A++ +RYL+ L K
Sbjct: 328 KLYFRDLPIPIITYDTYSKFIEAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKK 387
Query: 388 LSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFF 445
++ + N M N+ IV GP L+ P + +T + ++ I++ +I++ D F
Sbjct: 388 VTMNEKDNLMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKL--IVQILIENEDVLF 443
>ref|XP_000841.1| breakpoint cluster region [Homo sapiens]
Length = 1968
Score = 84.3 bits (205), Expect = 5e-15
Identities = 50/149 (33%), Positives = 75/149 (49%), Gaps = 2/149 (1%)
Query: 267 EIAFPIEACVTMLLECGMQEEGLFRVAPXXXXXXXXXXXXDCCVVDVQEYSA--DPHAIA 324
++ + + CV + GM+E G++RV+ D DV + D +AIA
Sbjct: 1763 KVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIA 1822
Query: 325 GALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKF 384
G LK Y RELPEPL T E Y + + + + K + N LP+AN +L+
Sbjct: 1823 GTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDH 1882
Query: 385 LSKLSEYQDVNKMTPSNMAIVLGPNLLWP 413
L +++E + VNKM+ N+A V GP LL P
Sbjct: 1883 LKRVAEKEAVNKMSLHNLATVFGPTLLRP 1911
Database: nr
Number of letters in database: 183,345,511
Number of sequences in database: 582,290
Lambda K H
0.315 0.130 0.372
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 232608103
Number of Sequences: 582290
Number of extensions: 8445759
Number of successful extensions: 22434
Number of sequences better than 10.0: 270
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 80
Number of HSP's that attempted gapping in prelim test: 21953
Number of HSP's gapped (non-prelim): 319
length of query: 818
length of database: 183,345,511
effective HSP length: 62
effective length of query: 756
effective length of database: 147,243,531
effective search space: 111316109436
effective search space used: 111316109436
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 75 (33.6 bits)
