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Angiogenesis

List of -TEMs -PEMs -NEMs

TEMs TEM1 TEM2 TEM3 TEM4 TEM5 TEM6 TEM7 TEM8 TEM9 TEM10 TEM11 TEM12 TEM13 TEM14 TEM15 TEM16 TEM17 TEM18 TEM19 TEM20 TEM21_1 TEM21_2 TEM22 TEM23 TEM24 TEM25 TEM26 TEM27 TEM28 TEM29 TEM30 TEM31_1 TEM31_2 TEM32 TEM33 TEM34 TEM35 TEM36 TEM37 TEM38 TEM39 TEM40 TEM41 TEM42 TEM43 TEM44 TEM45 TEM46

Summary -Overview of TEMs -extracellular TEMs -intrac. & membrane TEMs -TEM tissue distribution

Supplementary -SAGE -Seq.analysis Methods

FAQ

	BLAST against nr ProteinDB

BLASTP 2.1.1 [Aug-8-2000]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 
         (986 letters)

Database: nr
           582,290 sequences; 183,345,511 total letters

Distribution of 215 Blast Hits on the Query Sequence

---

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

ref|NP_006120.1|  bone morphogenetic protein 1, isoform 4, p...  2022  0.0
pir||B58788  procollagen C-endopeptidase (EC 3.4.24.19) prec...  2018  0.0
sp|P98063|BMP1_MOUSE  BONE MORPHOGENETIC PROTEIN 1 PRECURSOR...  1884  0.0
dbj|BAA11922.1|  (D83476) Xtld protein [Xenopus laevis]          1654  0.0
ref|NP_036597.1|  tolloid-like 2; KIAA0932 protein [Homo sap...  1598  0.0
ref|NP_036034.1|  tolloid-like 2 [Mus musculus] >gi|5410232|...  1598  0.0
gb|AAC60304.1|  (AF027596) tolloid [Danio rerio]                 1589  0.0
ref|NP_036596.1|  tolloid-like 1 [Homo sapiens] >gi|2735327|...  1586  0.0
gb|AAF86287.1|AF282732_1  (AF282732) tolloid-like protein [H...  1585  0.0
emb|CAC08820.1|  (AJ012462) colloid protein [Gallus gallus]      1575  0.0
dbj|BAA76776.1|  (AB023149) KIAA0932 protein [Homo sapiens]      1567  0.0
emb|CAA70854.1|  (Y09661) xolloid [Xenopus laevis]               1562  0.0
ref|NP_033416.1|  tolloid-like [Mus musculus] >gi|1421726|gb...  1553  0.0
ref|NP_001190.1|  bone morphogenetic protein 1, isoform 4, p...  1412  0.0
ref|NP_006119.1|  bone morphogenetic protein 1, isoform 4, p...  1409  0.0
ref|NP_006121.1|  bone morphogenetic protein 1, isoform 4, p...  1409  0.0
emb|CAA70853.1|  (Y09660) bone morphogenetic protein 1b [Xen...  1208  0.0
sp|P98070|BMP1_XENLA  BONE MORPHOGENETIC PROTEIN 1 PRECURSOR...  1199  0.0
gb|AAC02259.1|  (U75331) bone morphogenetic protein 1 [Gallu...  1174  0.0
ref|NP_006122.1|  bone morphogenetic protein 1, isoform 4, p...  1166  0.0
gb|AAF56328.1|  (AE003749) tok gene product [Drosophila mela...   946  0.0
pir||S58984  development protein tolkin (EC 3.4.24.-) - frui...   946  0.0
gb|AAA70057.1|  (U12634) tolloid related-1 [Drosophila melan...   946  0.0
pir||T31069  tolloid-BMP-1 like protein 1 - California sea h...   843  0.0
sp|P25723|TLD_DROME  DORSAL-VENTRAL PATTERNING TOLLOID PROTE...   801  0.0
sp|P98069|BMPH_STRPU  BONE MORPHOGENETIC PROTEIN 1 HOMOLOG P...   701  0.0
gb|AAC41710.1|  (L35279) bone morphogenetic protein [Homo sa...   613  e-174
pir||T30018  hypothetical protein F38E9.2 - Caenorhabditis e...   506  e-142
dbj|BAA75639.1|  (AB012139) procollagen C-proteinase 3 [Ratt...   471  e-131
ref|NP_006123.1|  bone morphogenetic protein 1, isoform 4, p...   428  e-118
gb|AAC02260.1|  (U75332) Tolloid [Gallus gallus]                  411  e-113
gb|AAF14258.1|AF137068_1  (AF137068) cubilin [Canis familiaris]   330  4e-89
ref|NP_001072.1|  cubilin precursor; cubilin; intrinsic fact...   330  5e-89
pir||T08618  intrinsic factor-B12 receptor CUBILIN precursor...   317  3e-85
gb|AAF68591.1|AF252808_1  (AF252808) tolloid [Drosophila sim...   286  8e-76
gb|AAF68588.1|  (AF252805) tolloid [Drosophila simulans]          286  8e-76
gb|AAF68585.1|  (AF252802) tolloid [Drosophila simulans]          286  8e-76
gb|AAF68589.1|AF252806_1  (AF252806) tolloid [Drosophila sim...   286  1e-75
gb|AAF68587.1|AF252804_1  (AF252804) tolloid [Drosophila sim...   286  1e-75
gb|AAF68586.1|AF252803_1  (AF252803) tolloid [Drosophila sim...   286  1e-75
gb|AAF68590.1|AF252807_1  (AF252807) tolloid [Drosophila sim...   285  1e-75
sp|P42664|UVS2_XENLA  EMBRYONIC PROTEIN UVS.2 PRECURSOR >gi|...   236  1e-60
gb|AAB30164.1|  TLD=bone morphogenetic protein BMP-1 homolog...   227  4e-58
emb|CAA05969.1|  (AJ003190) astacus egg astacin [Astacus ast...   222  1e-56
sp|P42662|ASTL_COTJA  ASTACIN LIKE METALLOENDOPEPTIDASE >gi|...   190  8e-47
pir||I51569  UVS.2 protein - African clawed frog (fragment) ...   180  7e-44
dbj|BAA89206.1|  (AB007617) MASP/P100 [Homo sapiens]              175  2e-42
dbj|BAA34864.1|  (D61695) mannose-binding protein associated...   174  5e-42
ref|NP_001870.1|  C4/C2 activating component of Ra-reactive ...   174  5e-42
sp|P48740|CRAR_HUMAN  COMPLEMENT-ACTIVATING COMPONENT OF RA-...   174  5e-42

>ref|NP_006120.1| bone morphogenetic protein 1, isoform 4, precursor; PCP [Homo
           sapiens]
 gb|AAA93462.1| (U50330) procollagen C-proteinase [Homo sapiens]
          Length = 986

 Score = 2022 bits (5181), Expect = 0.0
 Identities = 948/986 (96%), Positives = 948/986 (96%)

Query: 1   MPGVAXXXXXXXXXXXXXXXXXXDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
           MPGVA                  DLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60

Query: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXX 120
           EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQ               
Sbjct: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120

Query: 121 XXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
                PERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180

Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
           RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240

Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
           IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300

Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
           QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360

Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
           ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420

Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
           NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480

Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
           EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540

Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
           AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600

Query: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
           SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
Sbjct: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660

Query: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVN 720
           LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVN
Sbjct: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVN 720

Query: 721 TFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISST 780
           TFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISST
Sbjct: 721 TFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISST 780

Query: 781 PGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLR 840
           PGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLR
Sbjct: 781 PGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLR 840

Query: 841 FYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGY 900
           FYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGY
Sbjct: 841 FYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGY 900

Query: 901 GVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHS 960
           GVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHS
Sbjct: 901 GVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHS 960

Query: 961 DDTITKKGFHLRYTSTKFQDTLHSRK 986
           DDTITKKGFHLRYTSTKFQDTLHSRK
Sbjct: 961 DDTITKKGFHLRYTSTKFQDTLHSRK 986



>pir||B58788 procollagen C-endopeptidase (EC 3.4.24.19) precursor, tolloid-like
           splice form - human
          Length = 986

 Score = 2018 bits (5170), Expect = 0.0
 Identities = 946/986 (95%), Positives = 947/986 (95%)

Query: 1   MPGVAXXXXXXXXXXXXXXXXXXDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
           MPGVA                  DLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60

Query: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXX 120
           EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQ               
Sbjct: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120

Query: 121 XXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
                PERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180

Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
           RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240

Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
           IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300

Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
           QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360

Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
           ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420

Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
           NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480

Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
           EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540

Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
           AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600

Query: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
           SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
Sbjct: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660

Query: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVN 720
           LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVN
Sbjct: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVN 720

Query: 721 TFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISST 780
           TFGSYECQCRSGFVLHDNKHDCKEAGC+HKVTSTSGTITSPNWPDKYPSKKECTWAISST
Sbjct: 721 TFGSYECQCRSGFVLHDNKHDCKEAGCNHKVTSTSGTITSPNWPDKYPSKKECTWAISST 780

Query: 781 PGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLR 840
           PGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLR
Sbjct: 781 PGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLR 840

Query: 841 FYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGY 900
           FYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGY
Sbjct: 841 FYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGY 900

Query: 901 GVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHS 960
           GVELVFQTFEVEEETDCGYDYMELFDGYDSTAP LGRYCGSGPPEEVYSAGDSVLVKFHS
Sbjct: 901 GVELVFQTFEVEEETDCGYDYMELFDGYDSTAPSLGRYCGSGPPEEVYSAGDSVLVKFHS 960

Query: 961 DDTITKKGFHLRYTSTKFQDTLHSRK 986
           DDTITKKGFHLRYTSTKFQDTLHSRK
Sbjct: 961 DDTITKKGFHLRYTSTKFQDTLHSRK 986



>sp|P98063|BMP1_MOUSE BONE MORPHOGENETIC PROTEIN 1 PRECURSOR (BMP-1)
 pir||I49540 procollagen C-endopeptidase (EC 3.4.24.19) precursor, tolloid-like
           splice form - mouse
 gb|AAA37306.1| (L24755) bone morphogenetic protein [Mus musculus]
          Length = 991

 Score = 1884 bits (4826), Expect = 0.0
 Identities = 881/941 (93%), Positives = 895/941 (94%), Gaps = 2/941 (0%)

Query: 46  PCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQ 105
           P +      DIALDEEDLRAFQVQQA  LR+ TAR+ SIKAA  GN+S    Q T+GQPQ
Sbjct: 53  PLQGGCLPWDIALDEEDLRAFQVQQAAVLRQQTARRPSIKAA--GNSSALGGQGTSGQPQ 110

Query: 106 XXXXXXXXXXXXXXXXXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVT 165
                               PERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVT
Sbjct: 111 RESRGRWRGRPRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVT 170

Query: 166 FLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEH 225
           FLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHV+GFWHEH
Sbjct: 171 FLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEH 230

Query: 226 TRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDT 285
           TRPDRDRHVSIVRENIQPGQEYNFLKME QEVESLGETYDFDSIMHYARNTFSRGIFLDT
Sbjct: 231 TRPDRDRHVSIVRENIQPGQEYNFLKMEVQEVESLGETYDFDSIMHYARNTFSRGIFLDT 290

Query: 286 IVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAH 345
           IVPKYEVNGVKP IGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAH
Sbjct: 291 IVPKYEVNGVKPSIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAH 350

Query: 346 MHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPI 405
           MHCVWRISVTPGEKIILNFTS+DLYRSRLCWYDYVEVRDGFWRK  +RGRFCG KLPEPI
Sbjct: 351 MHCVWRISVTPGEKIILNFTSMDLYRSRLCWYDYVEVRDGFWRKVWVRGRFCGGKLPEPI 410

Query: 406 VSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRI 465
           VSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKD GHIQSPNYPDDYRPSKVCIWRI
Sbjct: 411 VSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDNGHIQSPNYPDDYRPSKVCIWRI 470

Query: 466 QVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRL 525
           QVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS LIGRYCGYE PDDIKSTSSRL
Sbjct: 471 QVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSNLIGRYCGYENPDDIKSTSSRL 530

Query: 526 WLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKR 585
           WLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKR
Sbjct: 531 WLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKR 590

Query: 586 RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
           RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK
Sbjct: 591 RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 650

Query: 646 YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKD 705
           YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKD
Sbjct: 651 YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKD 710

Query: 706 ECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPD 765
           ECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGC+HKVTSTSGTITSPNWPD
Sbjct: 711 ECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCEHKVTSTSGTITSPNWPD 770

Query: 766 KYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSK 825
           KYPSKKECTWAISSTPGHRVKLTF+EMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSK
Sbjct: 771 KYPSKKECTWAISSTPGHRVKLTFVEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSK 830

Query: 826 KPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYP 885
           KPEPVLATG+RMFLRFYSDNSVQRKGFQASH+TECGGQVRADVKTKDLYSHAQFGDNNYP
Sbjct: 831 KPEPVLATGNRMFLRFYSDNSVQRKGFQASHSTECGGQVRADVKTKDLYSHAQFGDNNYP 890

Query: 886 GGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPE 945
           GGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDY+ELFDGYDSTAPRLGRYCGSGPPE
Sbjct: 891 GGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYIELFDGYDSTAPRLGRYCGSGPPE 950

Query: 946 EVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK 986
           EVYSAGDSVLVKFHSDDTI+KKGFHLRYTSTKFQDTLHSRK
Sbjct: 951 EVYSAGDSVLVKFHSDDTISKKGFHLRYTSTKFQDTLHSRK 991



>dbj|BAA11922.1| (D83476) Xtld protein [Xenopus laevis]
          Length = 977

 Score = 1654 bits (4235), Expect = 0.0
 Identities = 746/960 (77%), Positives = 848/960 (87%), Gaps = 12/960 (1%)

Query: 27  DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKA 86
           DY+YDL EE   E ++YKDPCKAAAF GDIALDEE L  F++ + VDL +HT    S  A
Sbjct: 30  DYSYDL-EEVVEETIDYKDPCKAAAFWGDIALDEEVLANFKIDRIVDLTKHTIHTVSGAA 88

Query: 87  AVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXXXXXXXPERVWPDGVIPFVIGGNFTGS 146
               N S P         +                    PERVWPDGVIP+VI GNF+GS
Sbjct: 89  T---NISRPE--------KGRRTRKERRRSREKRASTSRPERVWPDGVIPYVISGNFSGS 137

Query: 147 QRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCD 206
           QRA+FRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCD
Sbjct: 138 QRAIFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCD 197

Query: 207 KFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDF 266
           KFGIVVHELGHV+GFWHEHTRPDRD +VSI+RENIQPGQEYNFLKMEP+EVESLGETYDF
Sbjct: 198 KFGIVVHELGHVIGFWHEHTRPDRDDNVSIIRENIQPGQEYNFLKMEPEEVESLGETYDF 257

Query: 267 DSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETL 326
           DSIMHYARNTFSRGIFLDTI+PKY+VNGV+PPIGQRTRLS GD+AQARKLYKCPACGETL
Sbjct: 258 DSIMHYARNTFSRGIFLDTILPKYDVNGVRPPIGQRTRLSSGDVAQARKLYKCPACGETL 317

Query: 327 QDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGF 386
           QDS GNFSSP +PNGYSA+MHCVWR+SVTPGEKIILNFTSLDLYRSRLCWYDY+EVRDGF
Sbjct: 318 QDSQGNFSSPGFPNGYSAYMHCVWRLSVTPGEKIILNFTSLDLYRSRLCWYDYIEVRDGF 377

Query: 387 WRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHI 446
           W+KAPLRGRFCG K+PE I+ST+SRLW+EFRSSSNWVGKGF AVYEA+CGG+VKKD GHI
Sbjct: 378 WKKAPLRGRFCGDKIPESIISTESRLWIEFRSSSNWVGKGFQAVYEALCGGEVKKDSGHI 437

Query: 447 QSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLI 506
           QSPNYPDDYRP+K C+W++ VSEGFHVG++FQSFEIERHDSCAYDYLE+RDG SE+S L+
Sbjct: 438 QSPNYPDDYRPNKACVWKLSVSEGFHVGISFQSFEIERHDSCAYDYLEIRDGSSETSPLV 497

Query: 507 GRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNT 566
           GR+CGY+KPDDIKS++++LW+KFVSDGSINKAGF++N+FKEVDECSRPN GGCEQRC+NT
Sbjct: 498 GRFCGYDKPDDIKSSTNQLWIKFVSDGSINKAGFSLNYFKEVDECSRPNNGGCEQRCVNT 557

Query: 567 LGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQ 626
           LGSYKC+CDPGYEL  DK+ CEAACGGFLTKLNGSI SPGWPKEYPPNKNCIWQLVAPTQ
Sbjct: 558 LGSYKCACDPGYELGQDKKSCEAACGGFLTKLNGSINSPGWPKEYPPNKNCIWQLVAPTQ 617

Query: 627 YRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFK 686
           YRISL+FD FETEGNDVCKYDFVEVRSGLT+DSKLHGKFCGSE P VITSQYNNMR+EFK
Sbjct: 618 YRISLKFDQFETEGNDVCKYDFVEVRSGLTSDSKLHGKFCGSELPAVITSQYNNMRIEFK 677

Query: 687 SDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAG 746
           SDNTVSKKGF+A+FFSDKDECS+DNGGCQ +C NT GSY CQCRSGF LH+NKHDCKEAG
Sbjct: 678 SDNTVSKKGFQANFFSDKDECSQDNGGCQHECTNTLGSYICQCRSGFTLHENKHDCKEAG 737

Query: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
           CDHK+T+++GTI+SPNWPDKYPSKK CTW I++TPGHRVKLT  E+D+ES  EC YDH+E
Sbjct: 738 CDHKMTTSTGTISSPNWPDKYPSKKICTWQITATPGHRVKLTVSEVDLESHQECLYDHVE 797

Query: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRA 866
           V+ GR+A++PVL RFCGSK P+P+++ G+ MFL+F SDNSVQ++GF    ++ CGG + A
Sbjct: 798 VYTGRNAQSPVLTRFCGSKIPDPIISPGNTMFLKFMSDNSVQKRGFLGELSSVCGGTLHA 857

Query: 867 DVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFD 926
           +V+T+DLYSHA+ GD+ +P G +C W IV+E GYGVELVFQ+FE+EEE DCGYDYMEL+D
Sbjct: 858 EVRTQDLYSHAKLGDDTHPSGTECLWHIVSEAGYGVELVFQSFELEEEPDCGYDYMELYD 917

Query: 927 GYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK 986
           G D  APRLGR+CGSGPPEEVYSAGD++ +KFHSDDTI KKGFH+RYTSTKFQDTLH+RK
Sbjct: 918 GPDEAAPRLGRFCGSGPPEEVYSAGDALTIKFHSDDTINKKGFHVRYTSTKFQDTLHARK 977



>ref|NP_036597.1| tolloid-like 2; KIAA0932 protein [Homo sapiens]
 gb|AAD42979.1|AF059516_1 (AF059516) tolloid-like 2 protein [Homo sapiens]
          Length = 1015

 Score = 1598 bits (4093), Expect = 0.0
 Identities = 723/982 (73%), Positives = 829/982 (83%), Gaps = 21/982 (2%)

Query: 26   ADYTYDLAEEDDSEPL-NYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTAR---- 80
            ADY+    EE   + L +Y DPCKAA F GDIALDE+DL+ F + +A D  + T      
Sbjct: 34   ADYSELDGEEGTEQQLEHYHDPCKAAVFWGDIALDEDDLKLFHIDKARDWTKQTVGATGH 93

Query: 81   -----KSSIKAAVPGNTSTPSCQSTNGQ-----------PQXXXXXXXXXXXXXXXXXXX 124
                 +     + P  T+  +     G+           P                    
Sbjct: 94   STGGLEEQASESSPDTTAMDTGTKEAGKDGRENTTLLHSPGTLHAAAKTFSPRVRRATTS 153

Query: 125  XPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCG 184
              ER+WP GVIP+VIGGNFTGSQRA+F+QAMRHWEKHTCVTF+ERTDE+S+IVF+YR CG
Sbjct: 154  RTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCG 213

Query: 185  CCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPG 244
            CCSYVGRRGGGPQAISIGKNCDKFGIV HELGHVVGFWHEHTRPDRD+HV+I+RENIQPG
Sbjct: 214  CCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPG 273

Query: 245  QEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTR 304
            QEYNFLKME  EV SLGETYDFDSIMHYARNTFSRG+FLDTI+P+ + NGV+P IGQR R
Sbjct: 274  QEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVR 333

Query: 305  LSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNF 364
            LS+GDIAQARKLYKCPACGETLQD+TGNFS+P +PNGY ++ HCVWRISVTPGEKI+LNF
Sbjct: 334  LSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNF 393

Query: 365  TSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVG 424
            TS+DL++SRLCWYDYVEVRDG+WRKAPL GRFCG K+PEP+VSTDSRLWVEFRSSSN +G
Sbjct: 394  TSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILG 453

Query: 425  KGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIER 484
            KGFFA YEA CGGD+ KD G IQSPNYPDDYRPSK C+WRI VSEGFHVGLTFQ+FEIER
Sbjct: 454  KGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIER 513

Query: 485  HDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
            HDSCAYDYLEVRDG +E S LIG +CGYEKP+D+KS+S+RLW+KFVSDGSINKAGFA NF
Sbjct: 514  HDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANF 573

Query: 545  FKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITS 604
            FKEVDECS P+ GGCE RC+NTLGSYKC+CDPGYELA DK+ CE ACGGF+TKLNG+ITS
Sbjct: 574  FKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITS 633

Query: 605  PGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
            PGWPKEYP NKNC+WQ+VAP QYRISLQF+ FE EGNDVCKYDFVEVRSGL+ D+KLHG+
Sbjct: 634  PGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGR 693

Query: 665  FCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGS 724
            FCGSE PEVITSQ NNMRVEFKSDNTVSK+GF+AHFFSDKDEC+KDNGGCQ +CVNTFGS
Sbjct: 694  FCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGS 753

Query: 725  YECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHR 784
            Y C+CR+G+ LH+N HDCKEAGC HK++S  GT+ SPNWPDKYPS++ECTW ISST GHR
Sbjct: 754  YLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHR 813

Query: 785  VKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSD 844
            VKLTF E +IE   ECAYDHLE++DG D+ AP+LGRFCGSKKP+P +A+GS MFLRFYSD
Sbjct: 814  VKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSD 873

Query: 845  NSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVEL 904
             SVQRKGFQA H+TECGG+++A+V+TK+LYSHAQFGDNNYP    C+WVIVAE+GYGVEL
Sbjct: 874  ASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVEL 933

Query: 905  VFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTI 964
             F+TFEVEEE DCGYDYME +DGYDS+APRLGR+CGSGP EE+YSAGDS++++F +DDTI
Sbjct: 934  TFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTI 993

Query: 965  TKKGFHLRYTSTKFQDTLHSRK 986
             KKGFH RYTSTKFQD LH +K
Sbjct: 994  NKKGFHARYTSTKFQDALHMKK 1015



>ref|NP_036034.1| tolloid-like 2 [Mus musculus]
 gb|AAD42993.1|AF073526_1 (AF073526) tolloid-like-2 protein [Mus musculus]
          Length = 1012

 Score = 1598 bits (4092), Expect = 0.0
 Identities = 722/979 (73%), Positives = 832/979 (84%), Gaps = 19/979 (1%)

Query: 27   DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARK----- 81
            DY     EE   + L+Y DPCKAA F GDIALDE+DL+ F + +A D  + +  K     
Sbjct: 34   DYGALEGEEGTEQQLHYHDPCKAAVFWGDIALDEDDLKLFHIDKAEDWTKPSIDKPGHDT 93

Query: 82   ---SSIKAAVPGNT-STPSCQSTNGQ----------PQXXXXXXXXXXXXXXXXXXXXPE 127
                   A  P +T S  S Q+              P                      E
Sbjct: 94   GGLEETSARWPNDTASNASIQAPRKDGKDATTFLPNPGTSNTTAKTFSARVRRATTSRTE 153

Query: 128  RVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCS 187
            R+WP GVIP+VIGGNFTG+QRA+F+QAMRHWEKHTCVTF+ERTDE+S+IVF+YR CGCCS
Sbjct: 154  RIWPGGVIPYVIGGNFTGTQRAIFKQAMRHWEKHTCVTFVERTDEESFIVFSYRTCGCCS 213

Query: 188  YVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEY 247
            YVGRRGGGPQAISIGKNCDKFGIV HELGHVVGFWHEHTRPDRD+HV+I+RENIQPGQEY
Sbjct: 214  YVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEY 273

Query: 248  NFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSK 307
            NFLKME  EV SLGETYDFDSIMHYARNTFSRG+FLDTI+P+ + NGV+P IGQR RLS+
Sbjct: 274  NFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRDDNGVRPTIGQRVRLSQ 333

Query: 308  GDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSL 367
            GDIAQARKLYKCPACGETLQD+TGNFS+P +PNGY ++ HCVWRISVTPGEKIILNFTS+
Sbjct: 334  GDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIILNFTSM 393

Query: 368  DLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGF 427
            DL++SRLCWYDYVE+RDG+WRKAPL GRFCG K+PE +VS+DSRLWVEFRSSS+ +GKGF
Sbjct: 394  DLFKSRLCWYDYVEIRDGYWRKAPLLGRFCGDKIPESLVSSDSRLWVEFRSSSSSLGKGF 453

Query: 428  FAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS 487
            FAVYEA+CGGD+ KD G IQSPNYPDDYRPSK C+WRI V +GFHVGLTFQSFEIERHDS
Sbjct: 454  FAVYEAMCGGDITKDAGQIQSPNYPDDYRPSKECVWRITVPDGFHVGLTFQSFEIERHDS 513

Query: 488  CAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKE 547
            CAYDYLE+RDG +E STLIG +CGYEKP+ +KS+++RLW+KFVSDGSINKAGFA NFFKE
Sbjct: 514  CAYDYLEIRDGPTEDSTLIGHFCGYEKPEAVKSSANRLWVKFVSDGSINKAGFAANFFKE 573

Query: 548  VDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGW 607
            VDECS P+ GGCEQRC+NTLGSY C+CDPGYELA DK+ CE ACGGF+TKLNG+ITSPGW
Sbjct: 574  VDECSWPDHGGCEQRCVNTLGSYTCACDPGYELAADKKTCEVACGGFITKLNGTITSPGW 633

Query: 608  PKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCG 667
            PKEYP NKNC+WQ+VAP QYRISLQF+ FE EGNDVCKYDFVEVRSGL+ D+KLHGKFCG
Sbjct: 634  PKEYPTNKNCVWQVVAPVQYRISLQFEAFELEGNDVCKYDFVEVRSGLSPDAKLHGKFCG 693

Query: 668  SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYEC 727
            SE PEVITSQ NNMRVEFKSDNTVSK+GF+AHFFSDKDEC+KDNGGCQQ+CVNTFGSY C
Sbjct: 694  SETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQQECVNTFGSYLC 753

Query: 728  QCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKL 787
            +CR+G+ LH+N HDCKEAGC +K++S  GT+ SPNWPDKYPS+KECTW ISST GHRVK+
Sbjct: 754  RCRNGYRLHENGHDCKEAGCAYKISSAEGTLMSPNWPDKYPSRKECTWNISSTAGHRVKI 813

Query: 788  TFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSV 847
            TF E +IE   ECAYDHLE++DG D+ AP+LGRFCGSKKP+PV+ATGS +FLRFYSD SV
Sbjct: 814  TFSEFEIEQHQECAYDHLELYDGTDSLAPILGRFCGSKKPDPVVATGSSLFLRFYSDASV 873

Query: 848  QRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQ 907
            QRKGFQA H+TECGG+++A+V+TK+LYSHAQFGDNNYP    C+WVIVAE+GYGVEL+F+
Sbjct: 874  QRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSQARCDWVIVAEDGYGVELIFR 933

Query: 908  TFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKK 967
            TFEVEEE DCGYD+ME +DGYDS+APRLGR+CGSGP EE+YSAGDS++++FH+DDTI KK
Sbjct: 934  TFEVEEEADCGYDFMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFHTDDTINKK 993

Query: 968  GFHLRYTSTKFQDTLHSRK 986
            GFH RYTSTKFQD LH RK
Sbjct: 994  GFHARYTSTKFQDALHMRK 1012



>gb|AAC60304.1| (AF027596) tolloid [Danio rerio]
          Length = 1022

 Score = 1589 bits (4070), Expect = 0.0
 Identities = 707/988 (71%), Positives = 836/988 (84%), Gaps = 30/988 (3%)

Query: 27   DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHT-------- 78
            D +YD  EE+ +E ++YKDPCKAA F GDIALD+EDL+ F +   +DL++ T        
Sbjct: 37   DDSYDYYEEEKTETIDYKDPCKAAVFWGDIALDDEDLKMFHIDGTIDLKQQTHGRQGHTS 96

Query: 79   ---------ARKSSIKAAV-----------PGNTSTPSCQSTNGQPQXXXXXXXXXXXXX 118
                      ++ S+   +           P N+S        G  +             
Sbjct: 97   GGLGEHVPTKKRGSLYLLLDRIRRLGFESWPVNSSKDVSSIKTGIRRVNSARNVKSRVPR 156

Query: 119  XXXXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVF 178
                    E++WP GVIP+VIGGNFTGSQRA+ +QAMRHWEK TCVTF+E+TDE+SYIVF
Sbjct: 157  AATSRA--EKIWPGGVIPYVIGGNFTGSQRAMLKQAMRHWEKQTCVTFIEKTDEESYIVF 214

Query: 179  TYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVR 238
            TYRPCGCCSYVGRRG GPQAISIGKNCDKFGIVVHELGHV+GFWHEHTRPDRD HV+I+R
Sbjct: 215  TYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIR 274

Query: 239  ENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPP 298
            +NIQPGQEYNF+KMEP +V SLGE YDFDSIMHYARNTFSRG+FLDTI+P  + NGV+P 
Sbjct: 275  DNIQPGQEYNFIKMEPGDVNSLGEPYDFDSIMHYARNTFSRGMFLDTILPSRDENGVRPA 334

Query: 299  IGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGE 358
            IGQRTRLSKGDI+QA+KLY+CPACGETLQDS GNFSSP YPNGY ++ HCVWRISVTPGE
Sbjct: 335  IGQRTRLSKGDISQAKKLYRCPACGETLQDSVGNFSSPGYPNGYPSYTHCVWRISVTPGE 394

Query: 359  KIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRS 418
            KI+LNFT++DLY+S LCWYDY+EVRDG+WRKAPL GRFCG K+PE +VSTDSR+W+EFRS
Sbjct: 395  KIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKAPLLGRFCGDKIPEVLVSTDSRMWIEFRS 454

Query: 419  SSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQ 478
            SSNWVGKGF AVYEAICGG++ KD G IQSPNYPDDYRPSK C+WRI VSEG+ VGL+FQ
Sbjct: 455  SSNWVGKGFAAVYEAICGGEISKDSGQIQSPNYPDDYRPSKECVWRITVSEGYSVGLSFQ 514

Query: 479  SFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKA 538
             FEIERHDSCAYDYLEVRDG SE+S LIGR+CGY+KP+DI+STS+ LW+KFVSDG++NKA
Sbjct: 515  VFEIERHDSCAYDYLEVRDGLSENSPLIGRFCGYDKPEDIRSTSNNLWMKFVSDGTVNKA 574

Query: 539  GFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL 598
            GFA NFFKE DEC +P+ GGCEQRC+NTLGS+KC+CDPGYELAPDK+ CEAACGG LTKL
Sbjct: 575  GFAANFFKEEDECLKPDNGGCEQRCVNTLGSFKCACDPGYELAPDKKSCEAACGGLLTKL 634

Query: 599  NGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTAD 658
            NG+IT+PGWPKEYPPNKNC+WQ+VAPTQYRIS+QF+ FE EGN+VCKYD+VEVRSGL++D
Sbjct: 635  NGTITTPGWPKEYPPNKNCVWQVVAPTQYRISMQFEAFELEGNEVCKYDYVEVRSGLSSD 694

Query: 659  SKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDC 718
            SKLHGK+CG+E PEVITSQYNNMR+EFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQ +C
Sbjct: 695  SKLHGKYCGTEVPEVITSQYNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHEC 754

Query: 719  VNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAIS 778
            +NT GSY CQCR+GF+LH+NKHDCKEA C+HK+ ST+GTI+SPNWPDKYPS+KECTW I+
Sbjct: 755  INTIGSYVCQCRNGFILHENKHDCKEAECEHKIHSTTGTISSPNWPDKYPSRKECTWDIT 814

Query: 779  STPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMF 838
            +TPGHRVK++F E +IE   ECAYDHLE FDG   K P+L R CG+K PEP+++TG++M+
Sbjct: 815  ATPGHRVKISFNEFEIEQHQECAYDHLEAFDGDSDKTPILSRLCGNKIPEPLISTGNKMY 874

Query: 839  LRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEE 898
            LRF SD SVQRKGFQA+H+TECGG+++A+ + K+LYSHAQFGDNNYPG  DCEW+IVAE 
Sbjct: 875  LRFISDASVQRKGFQATHSTECGGRLKAEARQKNLYSHAQFGDNNYPGHTDCEWLIVAES 934

Query: 899  GYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKF 958
            GYG+EL F TFEVEEE DCGYDY+EL+DGYD+ A ++GR+CGSGP EE+YSAGD+VL+ F
Sbjct: 935  GYGIELTFTTFEVEEEADCGYDYIELYDGYDTGAHKIGRFCGSGPREELYSAGDAVLIHF 994

Query: 959  HSDDTITKKGFHLRYTSTKFQDTLHSRK 986
            HSDDTI+KKGFH+RYTSTKFQ+ LH+RK
Sbjct: 995  HSDDTISKKGFHIRYTSTKFQEALHTRK 1022



>ref|NP_036596.1| tolloid-like 1 [Homo sapiens]
 gb|AAB93878.1| (U91963) tolloid-like protein [Homo sapiens]
          Length = 1013

 Score = 1586 bits (4061), Expect = 0.0
 Identities = 710/997 (71%), Positives = 835/997 (83%), Gaps = 54/997 (5%)

Query: 27   DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRR-------HTA 79
            DYT+D  EED +E ++YKDPCKAA F GDIALD+EDL  FQ+ + +DL +       HT 
Sbjct: 34   DYTFDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTT 93

Query: 80   ------------------------------RKSSIKAAVPGNTSTPSCQSTNGQPQXXXX 109
                                          + +++K  VP   S  +    N  P+    
Sbjct: 94   GGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQN--EKNRVPRAATS 151

Query: 110  XXXXXXXXXXXXXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLER 169
                             ER+WP GVIP+VIGGNFTGSQRA+F+QAMRHWEKHTCVTF+ER
Sbjct: 152  RT---------------ERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIER 196

Query: 170  TDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPD 229
            +DE+SYIVFTYRPCGCCSYVGRRG GPQAISIGKNCDKFGIVVHELGHV+GFWHEHTRPD
Sbjct: 197  SDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPD 256

Query: 230  RDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPK 289
            RD HV+I+RENIQPGQEYNFLKMEP EV SLGE YDFDSIMHYARNTFSRG+FLDTI+P 
Sbjct: 257  RDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPS 316

Query: 290  YEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCV 349
             + NG++P IGQRTRLSKGDIAQARKLY+CPACGETLQ+S GN SSP +PNGY ++ HC+
Sbjct: 317  RDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCI 376

Query: 350  WRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTD 409
            WR+SVTPGEKI+LNFT++DLY+S LCWYDY+EVRDG+WRK+PL GRFCG KLPE + STD
Sbjct: 377  WRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTD 436

Query: 410  SRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSE 469
            SR+W+EFRSSSNWVGKGF AVYEAICGG+++K+ G IQSPNYPDDYRP K C+W+I VSE
Sbjct: 437  SRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSE 496

Query: 470  GFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKF 529
             +HVGLTFQSFEIERHD+CAYDYLEVRDG SE+S LIGR+CGY+KP+DI+STS+ LW+KF
Sbjct: 497  SYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKF 556

Query: 530  VSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEA 589
            VSDG++NKAGFA NFFKE DEC++P+RGGCEQRCLNTLGSY+C+C+PGYEL PD+R CEA
Sbjct: 557  VSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEA 616

Query: 590  ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
            ACGG LTKLNG+IT+PGWPKEYPPNKNC+WQ+VAPTQYRIS++F+FFE EGN+VCKYD+V
Sbjct: 617  ACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYV 676

Query: 650  EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709
            E+ SGL+++SKLHGKFCG+E PEVITSQ+NNMR+EFKSDNTVSKKGFKAHFFSDKDECSK
Sbjct: 677  EIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSK 736

Query: 710  DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPS 769
            DNGGCQ +CVNT GSY CQCR+GFVLHDNKHDCKEA C+ K+ S SG ITSPNWPDKYPS
Sbjct: 737  DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPS 796

Query: 770  KKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829
            +KECTW IS+TPGHR+KL F E +IE   ECAYDHLEVFDG   K+P+LGR CG+K P+P
Sbjct: 797  RKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDP 856

Query: 830  VLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVD 889
            ++ATG++MF+RF SD SVQRKGFQA+H+TECGG+++A+ K +DLYSHAQFGDNNYPG VD
Sbjct: 857  LVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVD 916

Query: 890  CEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYS 949
            CEW++V+E G  +EL FQTFEVEEE DCGYDY+ELFDG DSTA  LGR+CGSGPPEE+YS
Sbjct: 917  CEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYS 976

Query: 950  AGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK 986
             GDSVL+ FH+DDTI KKGFH+RY S ++ DT H++K
Sbjct: 977  IGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK 1013



>gb|AAF86287.1|AF282732_1 (AF282732) tolloid-like protein [Homo sapiens]
          Length = 1013

 Score = 1585 bits (4058), Expect = 0.0
 Identities = 710/997 (71%), Positives = 834/997 (83%), Gaps = 54/997 (5%)

Query: 27   DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRR-------HTA 79
            DYT+D  EED +E ++YKDPCKAA F GDIALD+EDL  FQ+ + +DL +       HT 
Sbjct: 34   DYTFDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTT 93

Query: 80   ------------------------------RKSSIKAAVPGNTSTPSCQSTNGQPQXXXX 109
                                          + +++K  VP   S  +    N  P+    
Sbjct: 94   GGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQN--EKNRVPRAATS 151

Query: 110  XXXXXXXXXXXXXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLER 169
                             ERVWP GVIP+VIGGNFTGSQRA+F+QAMRHWEKHTCVTF+ER
Sbjct: 152  RT---------------ERVWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIER 196

Query: 170  TDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPD 229
            +DE+SYIVFTYRPCGCCSYVGRRG GPQAISIGKNCDKFGIVVHELGHV+GFWHEHTRPD
Sbjct: 197  SDEESYIVFTYRPCGCCSYVGRRGSGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPD 256

Query: 230  RDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPK 289
            RD HV+I+RENIQPGQEYNFLKMEP E  SLGE YDFDSIMHYARNTFSRG+FLDTI+P 
Sbjct: 257  RDNHVTIIRENIQPGQEYNFLKMEPGEANSLGERYDFDSIMHYARNTFSRGMFLDTILPS 316

Query: 290  YEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCV 349
             + NG++P IGQRTRLSKGDIAQARKLY+CPACGETLQ+S GN SSP +PNGY ++ HC+
Sbjct: 317  RDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCI 376

Query: 350  WRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTD 409
            WR+SVTPGEKI+LNFT++DLY+S LCWYDY+EVRDG+WRK+PL GRFCG KLPE + STD
Sbjct: 377  WRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTD 436

Query: 410  SRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSE 469
            SR+W+EFRSSSNWVGKGF AVYEAICGG+++K+ G IQSPNYPDDYRP K C+W+I VSE
Sbjct: 437  SRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSE 496

Query: 470  GFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKF 529
             +HVGLTFQSFEIERHD+CAYDYLEVRDG SE+S LIGR+CGY+KP+DI+STS+ LW+KF
Sbjct: 497  SYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKF 556

Query: 530  VSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEA 589
            VSDG++NKAGFA NFFKE DEC++P+RGGCEQRCLNTLGSY+C+C+PGYEL PD+R CEA
Sbjct: 557  VSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEA 616

Query: 590  ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
            ACGG LTKLNG+IT+PGWPKEYPPNKNC+WQ+VAPTQYRIS++F+FFE EGN+VCKYD+V
Sbjct: 617  ACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYV 676

Query: 650  EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709
            E+ SGL+++SKLHGKFCG+E PEVITSQ+NNMR+EFKSDNTVSKKGFKAHFFSDKDECSK
Sbjct: 677  EIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSK 736

Query: 710  DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPS 769
            DNGGCQ +CVNT GSY CQCR+GFVLHDNKHDCKEA C+ K+ S SG ITSPNWPDKYPS
Sbjct: 737  DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPS 796

Query: 770  KKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829
            +KECTW IS+TPGHR+KL F E +IE   ECAYDHLEVFDG   K+P+LGR CG+K P+P
Sbjct: 797  RKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDP 856

Query: 830  VLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVD 889
            ++ATG++MF+RF SD SVQRKGFQA+H+TECGG+++A+ K +DLYSHAQFGDNNYPG VD
Sbjct: 857  LVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVD 916

Query: 890  CEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYS 949
            CEW++V+E G  +EL FQTFEVEEE DCGYDY+ELFDG DSTA  LGR+CGSGPPEE+YS
Sbjct: 917  CEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYS 976

Query: 950  AGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK 986
             GDSVL+ FH+DDTI KKGFH+RY S ++ DT H++K
Sbjct: 977  IGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK 1013



>emb|CAC08820.1| (AJ012462) colloid protein [Gallus gallus]
          Length = 1008

 Score = 1575 bits (4033), Expect = 0.0
 Identities = 699/980 (71%), Positives = 828/980 (84%), Gaps = 21/980 (2%)

Query: 27   DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKA 86
            DYTYD  EED +E ++YKDPCKAA F GDIALD+EDL+ FQ+ + +DL +H+  +     
Sbjct: 30   DYTYDFTEEDKAEAIDYKDPCKAAVFWGDIALDDEDLKIFQIDRTIDLTQHSNERLGHNT 89

Query: 87   AVPGNTSTPSCQST------------NGQPQXXXXXXXXXXXXXXX--------XXXXXP 126
               G       +              +G  Q                             
Sbjct: 90   GGFGEHGMSKKRGALYQLIERIRRFGSGFEQNNTSKGRTTVKFSGKNEKNRFPRAATSRT 149

Query: 127  ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCC 186
            ER+WP GVIP+VIGGNFTG+QRA+F+QAMRHWEK+TCVTF+ER+DE+SYIVFTYRPCGCC
Sbjct: 150  ERIWPGGVIPYVIGGNFTGTQRAMFKQAMRHWEKYTCVTFIERSDEESYIVFTYRPCGCC 209

Query: 187  SYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQE 246
            SYVGRRG GPQAISIGKNCDKFGIVVHELGHV+GFWHEHTRPDRD HV+I+RENIQPGQE
Sbjct: 210  SYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRENIQPGQE 269

Query: 247  YNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLS 306
            YNFLKMEP EV SLGE YDFDSIMHYARNTFSRG+FLDTI+P  + NG++P IGQRTRLS
Sbjct: 270  YNFLKMEPGEVNSLGEPYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLS 329

Query: 307  KGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS 366
            KGDIAQARKLY+CPACGETLQ+STGNFSSP +PNGY ++ HC+WRISVTPGEKI+LNFT+
Sbjct: 330  KGDIAQARKLYRCPACGETLQESTGNFSSPGFPNGYPSYTHCIWRISVTPGEKIVLNFTT 389

Query: 367  LDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKG 426
            +DLY+S LCWYDY+EVRDG+WRK+PL GRFCG KLPE + S+DSR+W+EFRSSSNWVGKG
Sbjct: 390  MDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLASSDSRMWIEFRSSSNWVGKG 449

Query: 427  FFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD 486
            F AVYEAICGG++ K+ G IQSPNYPDDYRP K C+W+I VSE ++VGLTFQ+FEIERHD
Sbjct: 450  FAAVYEAICGGEIHKNEGQIQSPNYPDDYRPMKECVWKITVSENYNVGLTFQAFEIERHD 509

Query: 487  SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK 546
            +CAYDYLE+RDG +E+S LIG +CGY+KP+DI+STS+ LW+KFVSDG++NKAGFA NFFK
Sbjct: 510  NCAYDYLEIRDGMNENSPLIGHFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK 569

Query: 547  EVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPG 606
            E   C +P+ GGCEQRC+NTLGSY+C+CDPGYEL PDK+ CEAACGG LTKLNG+I +PG
Sbjct: 570  EEMMC-QPDNGGCEQRCVNTLGSYQCACDPGYELGPDKKSCEAACGGLLTKLNGTIPTPG 628

Query: 607  WPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
            WPKEYPPNKNC+WQ+VAPTQYRIS++F+FFE EGN+VCKYD+VE+RSGL++DSKLHGKFC
Sbjct: 629  WPKEYPPNKNCVWQVVAPTQYRISMKFEFFELEGNEVCKYDYVEIRSGLSSDSKLHGKFC 688

Query: 667  GSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYE 726
            G+E PEVITSQYNNMR+EF+SDNTVSKKGFKAHFFSDKDECSKDNGGCQ +C+NT GSY 
Sbjct: 689  GTEVPEVITSQYNNMRIEFRSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECINTVGSYV 748

Query: 727  CQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVK 786
            CQCR+GFVLH+NKHDCKEA C+ K+ S +G I SPNWPDKYPS+KECTW IS+TPG RVK
Sbjct: 749  CQCRNGFVLHENKHDCKEAECEQKIHSPNGIIMSPNWPDKYPSRKECTWEISATPGQRVK 808

Query: 787  LTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNS 846
            LTF E +IE   ECAYDHLEVFDG   K+P+LGR CGSK PEP++ATG++MFLRF SD S
Sbjct: 809  LTFNEFEIEQHQECAYDHLEVFDGESEKSPILGRLCGSKIPEPLIATGNKMFLRFISDAS 868

Query: 847  VQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVF 906
            VQRKGFQA+H+TECGG+++A+ K KDLYSHAQFGDNNYP   DC+W++VAE GY VEL+F
Sbjct: 869  VQRKGFQATHSTECGGRLKAETKPKDLYSHAQFGDNNYPVQADCDWLLVAERGYRVELMF 928

Query: 907  QTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITK 966
            QTFEVEEE DCGYDY+ELFDG+D TA RLGR+CGSGPPEE+YSAG+++L+ FH+DDTI K
Sbjct: 929  QTFEVEEEADCGYDYVELFDGHDKTAMRLGRFCGSGPPEEIYSAGETLLLHFHTDDTINK 988

Query: 967  KGFHLRYTSTKFQDTLHSRK 986
            KGFH+RY S K+ D++H++K
Sbjct: 989  KGFHIRYRSIKYPDSVHTKK 1008



>dbj|BAA76776.1| (AB023149) KIAA0932 protein [Homo sapiens]
          Length = 926

 Score = 1567 bits (4012), Expect = 0.0
 Identities = 692/860 (80%), Positives = 785/860 (90%)

Query: 127 ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCC 186
           ER+WP GVIP+VIGGNFTGSQRA+F+QAMRHWEKHTCVTF+ERTDE+S+IVF+YR CGCC
Sbjct: 67  ERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCC 126

Query: 187 SYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQE 246
           SYVGRRGGGPQAISIGKNCDKFGIV HELGHVVGFWHEHTRPDRD+HV+I+RENIQPGQE
Sbjct: 127 SYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQE 186

Query: 247 YNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLS 306
           YNFLKME  EV SLGETYDFDSIMHYARNTFSRG+FLDTI+P+ + NGV+P IGQR RLS
Sbjct: 187 YNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLS 246

Query: 307 KGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS 366
           +GDIAQARKLYKCPACGETLQD+TGNFS+P +PNGY ++ HCVWRISVTPGEKI+LNFTS
Sbjct: 247 QGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTS 306

Query: 367 LDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKG 426
           +DL++SRLCWYDYVEVRDG+WRKAPL GRFCG K+PEP+VSTDSRLWVEFRSSSN +GKG
Sbjct: 307 MDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKG 366

Query: 427 FFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD 486
           FFA YEA CGGD+ KD G IQSPNYPDDYRPSK C+WRI VSEGFHVGLTFQ+FEIERHD
Sbjct: 367 FFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRIMVSEGFHVGLTFQAFEIERHD 426

Query: 487 SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK 546
           SCAYDYLEVRDG +E S LIG +CGYEKP+D+KS+S+RLW+KFVSDGSINKAGFA NFFK
Sbjct: 427 SCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFK 486

Query: 547 EVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPG 606
           EVDECS P+ GGCE RC+NTLGSYKC+CDPGYELA DK+ CE ACGGF+TKLNG+ITSPG
Sbjct: 487 EVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPG 546

Query: 607 WPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
           WPKEYP NKNC+WQ+VAP QYRISLQF+ FE EGNDVCKYDFVEVRSGL+ D+KLHG+FC
Sbjct: 547 WPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFC 606

Query: 667 GSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYE 726
           GSE PEVITSQ NNMRVEFKSDNTVSK+GF+AHFFSDKDEC+KDNGGCQ +CVNTFGSY 
Sbjct: 607 GSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYL 666

Query: 727 CQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVK 786
           C+CR+G+ LH+N HDCKEAGC HK++S  GT+ SPNWPDKYPS++ECTW ISST GHRVK
Sbjct: 667 CRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVK 726

Query: 787 LTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNS 846
           LTF E +IE   ECAYDHLE++DG D+ AP+LGRFCGSKKP+P +A+GS MFLRFYSD S
Sbjct: 727 LTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDAS 786

Query: 847 VQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVF 906
           VQRKGFQA H+TECGG+++A+V+TK+LYSHAQFGDNNYP    C+WVIVAE+GYGVEL F
Sbjct: 787 VQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTF 846

Query: 907 QTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITK 966
           +TFEVEEE DCGYDYME +DGYDS+APRLGR+CGSGP EE+YSAGDS++++F +DDTI K
Sbjct: 847 RTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINK 906

Query: 967 KGFHLRYTSTKFQDTLHSRK 986
           KGFH RYTSTKFQD LH +K
Sbjct: 907 KGFHARYTSTKFQDALHMKK 926



>emb|CAA70854.1| (Y09661) xolloid [Xenopus laevis]
          Length = 1019

 Score = 1562 bits (4000), Expect = 0.0
 Identities = 700/981 (71%), Positives = 825/981 (83%), Gaps = 23/981 (2%)

Query: 29   TYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLR--RH-----TARK 81
            ++D   ED+ E  +YKDPCKAAA+ GDIALDE+DL+     ++ DLR  RH     T   
Sbjct: 38   SFDYLMEDNPEEFDYKDPCKAAAYWGDIALDEDDLKWIFKNKSNDLRNTRHNQTHPTTDN 97

Query: 82   SSIKAAVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXXX----------------XXXX 125
             S K        T S  ++    +                                    
Sbjct: 98   FSEKLGTGSQNETSSNLNSKKVKKGSRLKLLIAEKAATETNSTFQVQTSNDRVRRAATSR 157

Query: 126  PERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGC 185
             ER+WP G+IP+ I GNFTG+QRA+F+QAMRHW+KHTCVTF+ERTDE+S+IVFTYRPCGC
Sbjct: 158  TERIWPGGIIPYAIAGNFTGTQRAIFKQAMRHWKKHTCVTFVERTDEESFIVFTYRPCGC 217

Query: 186  CSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQ 245
            CSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRD HVSI+RENIQPGQ
Sbjct: 218  CSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDEHVSIIRENIQPGQ 277

Query: 246  EYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRL 305
            EYNFLKMEP EV SLGETYDFDSIMHYARNTFSRG+FLDTI+P+     V+P IGQR RL
Sbjct: 278  EYNFLKMEPGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRRIDTSVRPTIGQRIRL 337

Query: 306  SKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFT 365
            S+GDIAQA+KLYKCPACGETLQDS+GNFS+P YP+GY ++ HC+WRISVTPGEKIILNFT
Sbjct: 338  SQGDIAQAKKLYKCPACGETLQDSSGNFSAPGYPSGYPSYTHCIWRISVTPGEKIILNFT 397

Query: 366  SLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGK 425
            ++DL++SRLCWYDY+E+RDG+WRKA L GR CG KLP+PI+S+DS+LW+EFRSSSN +GK
Sbjct: 398  TMDLFKSRLCWYDYIEIRDGYWRKAALLGRLCGDKLPDPIISSDSKLWIEFRSSSNILGK 457

Query: 426  GFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERH 485
            GFFA YEAICGGD+KKD G IQSPNYPDDYRP+K CIW+I VSEGF VGL+FQ+FEIERH
Sbjct: 458  GFFAAYEAICGGDIKKDSGQIQSPNYPDDYRPAKECIWKITVSEGFLVGLSFQAFEIERH 517

Query: 486  DSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFF 545
            D+CAYDYLEVRDG SE   LIGR+CGYEKP+DIKSTS++LW+KF SDGSINKAGF+ NFF
Sbjct: 518  DNCAYDYLEVRDGFSEDHALIGRFCGYEKPEDIKSTSNKLWIKFASDGSINKAGFSANFF 577

Query: 546  KEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSP 605
            KE+DECSRP+ GGC QRC+NTLGSYKC C+PG+EL  DK+ CEAACGGF+T+LNG+ITSP
Sbjct: 578  KEMDECSRPDNGGCSQRCVNTLGSYKCVCEPGFELTADKKSCEAACGGFITQLNGTITSP 637

Query: 606  GWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKF 665
            GWPKEYP NKNC+WQ+VAP QYRISLQF+ FE EGNDVCKYD++E+RSGL+++SKLHGKF
Sbjct: 638  GWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDYLEIRSGLSSESKLHGKF 697

Query: 666  CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSY 725
            CG EKPEVITSQ N +R+EFKSDNTVSKKGFKA+FFSDKDECSKDNGGCQ DCVNTFGSY
Sbjct: 698  CGPEKPEVITSQGNTVRIEFKSDNTVSKKGFKANFFSDKDECSKDNGGCQHDCVNTFGSY 757

Query: 726  ECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRV 785
             CQC++GF+LH+N HDCKEAGC+ K+ +  GTI+SPNWP+KYPS+KECTW IS T GHRV
Sbjct: 758  ICQCKNGFILHENGHDCKEAGCEQKLLNAEGTISSPNWPEKYPSRKECTWDISVTAGHRV 817

Query: 786  KLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDN 845
            KL F + +IE   ECAYDHLE++DG + KA +LGRFCGSK+P PV+A+ + MFLRFYSD 
Sbjct: 818  KLVFTDFEIEQHQECAYDHLELYDGPNGKAAILGRFCGSKEPSPVVASTNNMFLRFYSDA 877

Query: 846  SVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELV 905
            SVQRKGFQA ++ ECGG+++A+++T D+YSHAQFGDNNYP   +CEWVIVAE+GYGVEL+
Sbjct: 878  SVQRKGFQAKYSPECGGRLKAEIQTNDIYSHAQFGDNNYPVQSNCEWVIVAEDGYGVELI 937

Query: 906  FQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTIT 965
            FQTFE+EEE+DCGYDYME++DGYDSTAPRLGRYCGSGPPEE+YSAGDS++++FH+DDTI 
Sbjct: 938  FQTFEIEEESDCGYDYMEVYDGYDSTAPRLGRYCGSGPPEEMYSAGDSIMIRFHTDDTIN 997

Query: 966  KKGFHLRYTSTKFQDTLHSRK 986
            KKGFH +YTSTKFQD LH R+
Sbjct: 998  KKGFHGQYTSTKFQDALHMRR 1018



>ref|NP_033416.1| tolloid-like [Mus musculus]
 gb|AAC52654.1| (U34042) mammalian tolloid-like protein [Mus musculus]
          Length = 1013

 Score = 1553 bits (3978), Expect = 0.0
 Identities = 686/979 (70%), Positives = 819/979 (83%), Gaps = 20/979 (2%)

Query: 27   DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKA 86
            DYT+D  EED +EP++YKDPCKAA F GDIALD+EDL  FQ+ + +DL +    K     
Sbjct: 34   DYTFDGNEEDKTEPIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQSPFGKLGHIT 93

Query: 87   AVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXXXXXXXP-------------------- 126
               G+   P  +    Q                      P                    
Sbjct: 94   GGFGDHGMPKKRGALYQLIERIRRIGSGLEQNNTMKGKAPPKLSEQSEKNRVPRAATSRT 153

Query: 127  ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCC 186
            ER+WP GVIP+VIGGNFTGSQRA+F+QAMRHWEKHTCVTF ER+DE+SYIVFTYRPCGCC
Sbjct: 154  ERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFTERSDEESYIVFTYRPCGCC 213

Query: 187  SYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQE 246
            SYVGRRG GPQAISIGKNCDKFGIVVHELGHV+GFWHEHTRPDRD HV+I+RENIQPGQE
Sbjct: 214  SYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQE 273

Query: 247  YNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLS 306
            YNFLKMEP EV SLGE YDFDSIMHYARNTFSRG+FLDTI+P  + NG++P IGQRTRLS
Sbjct: 274  YNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLS 333

Query: 307  KGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS 366
            KGDIAQARKLY+CPACGETLQ+S+GN SSP +PNGY ++ HC+WR+SVTPGEKI+LNFT+
Sbjct: 334  KGDIAQARKLYRCPACGETLQESSGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT 393

Query: 367  LDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKG 426
            +DLY+S LCWYDY+EVRDG+WRK+PL GRFCG K+   + STDSR+W+EFRSSSNWVGKG
Sbjct: 394  MDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKVAGVLTSTDSRMWIEFRSSSNWVGKG 453

Query: 427  FFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD 486
            F AVYEAICGG+++K+ G IQSPNYPDDYRP K C+W+I VSEG+HVGLTFQ+FEIERHD
Sbjct: 454  FAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKIMVSEGYHVGLTFQAFEIERHD 513

Query: 487  SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK 546
            SCAYD+LEVRDG SE+S LIGR+CGY+KP+DI+STS+ LW+KFVSDG++NKAGFA NFFK
Sbjct: 514  SCAYDHLEVRDGASENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK 573

Query: 547  EVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPG 606
            E DEC++P+RGGCEQRCLNTLGSY+C+C+PGYEL PD+R CEAACGG LTKLNG+IT+PG
Sbjct: 574  EEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPG 633

Query: 607  WPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
            WPKEYPPNKNC+WQ++AP+QYRIS++F+FFE EGN+VCKYD+VE+ SG +++SKLHGKFC
Sbjct: 634  WPKEYPPNKNCVWQVIAPSQYRISVKFEFFELEGNEVCKYDYVEIWSGPSSESKLHGKFC 693

Query: 667  GSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYE 726
            G++ PEV+TS +NNMR+EFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQ +CVNT GSY 
Sbjct: 694  GADIPEVMTSHFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYT 753

Query: 727  CQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVK 786
            CQCR+GFVLH+NKHDCKEA C+ K+ S SG ITSPNWPDKYPS+KECTW IS+ PGHR+ 
Sbjct: 754  CQCRNGFVLHENKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWVISAIPGHRIT 813

Query: 787  LTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNS 846
            L F E ++E   ECAYDHLE+FDG   K+P+LGR CGSK P+P++ATG+ MF+RF SD S
Sbjct: 814  LAFNEFEVEQHQECAYDHLEIFDGETEKSPILGRLCGSKIPDPLMATGNEMFIRFISDAS 873

Query: 847  VQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVF 906
            VQRKGFQA+H+TECGG+++A+ K +DLYSHAQFGDNNYPG +DCEW++V+E G  +EL F
Sbjct: 874  VQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQLDCEWLLVSERGSRLELSF 933

Query: 907  QTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITK 966
            QTFEVEEE DCGYDY+E+FDG  S A  LGR+CGSGPPEE+YS GD  L+ FH+DDTI K
Sbjct: 934  QTFEVEEEADCGYDYVEVFDGLSSKAVGLGRFCGSGPPEEIYSIGDVALIHFHTDDTINK 993

Query: 967  KGFHLRYTSTKFQDTLHSR 985
            KGF++RY S ++ +T+H++
Sbjct: 994  KGFYIRYKSIRYPETMHAK 1012



>ref|NP_001190.1| bone morphogenetic protein 1, isoform 4, precursor; PCP [Homo
           sapiens]
 sp|P13497|BMP1_HUMAN BONE MORPHOGENETIC PROTEIN 1 PRECURSOR (BMP-1)
 pir||BMHU1 procollagen C-endopeptidase (EC 3.4.24.19) precursor, splice form
           BMP1 - human
 gb|AAA51833.1| (M22488) bone morphogenetic protein 1 [Homo sapiens]
          Length = 730

 Score = 1412 bits (3614), Expect = 0.0
 Identities = 665/704 (94%), Positives = 666/704 (94%)

Query: 1   MPGVAXXXXXXXXXXXXXXXXXXDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
           MPGVA                  DLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60

Query: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXX 120
           EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQ               
Sbjct: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120

Query: 121 XXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
                PERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180

Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
           RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240

Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
           IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300

Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
           QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360

Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
           ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420

Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
           NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480

Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
           EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540

Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
           AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600

Query: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
           SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
Sbjct: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660

Query: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDK 704
           LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS+K
Sbjct: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEK 704



 Score =  311 bits (788), Expect = 3e-83
 Identities = 161/427 (37%), Positives = 231/427 (53%), Gaps = 47/427 (11%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CG  ++   G+  SP YP+ Y     C+WRI V+ G  + L F S ++ R   C YDY+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553
           VRDG    + L GR+CG + P+ I ST SRLW++F S  + + K  FAV           
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431

Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
                                             EA CGG + K  G I SP +P +Y P
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457

Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
           +K CIW++     + + L F  FE E +D C YD++EVR G +  S L G++CG EKP+ 
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517

Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDN-GGCQQDCVNTFGSYECQCRSG 732
           I S  + + ++F SD +++K GF  +FF + DECS+ N GGC+Q C+NT GSY+C C  G
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577

Query: 733 FVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEM 792
           + L  +K  C EA C   +T  +G+ITSP WP +YP  K C W + +   +R+ L F   
Sbjct: 578 YELAPDKRRC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFF 636

Query: 793 DIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGF 852
           + E    C YD +EV  G  A + + G+FCGS+KPE + +  + M + F SDN+V +KGF
Sbjct: 637 ETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696

Query: 853 QASHATE 859
           +A   +E
Sbjct: 697 KAHFFSE 703



 Score =  210 bits (529), Expect = 6e-53
 Identities = 127/427 (29%), Positives = 189/427 (43%), Gaps = 82/427 (19%)

Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
           ACG  L    G+ +SP +P  Y  + +C+W++      +I L F   +   + +C YD+V
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380

Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709
           EVR G    + L G+FCGS+ PE I S  + + VEF+S +    KGF A +         
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431

Query: 710 DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPS 769
                                             EA C   V    G I SPN+PD Y  
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457

Query: 770 KKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829
            K C W I  + G  V LTF   +IE    CAYD+LEV DG    + ++GR+CG +KP+ 
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517

Query: 830 VLATGSRMFLRFYSDNSVQRKGFQAS---HATECGGQVRADVKTKDLYSHAQFG------ 880
           + +T SR++L+F SD S+ + GF  +      EC    R   + + L +   +       
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577

Query: 881 ------------------------------DNNYPGGVDCEWVIVAEEGYGVELVFQTFE 910
                                            YP   +C W +VA   Y + L F  FE
Sbjct: 578 YELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637

Query: 911 VEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFH 970
            E    C YD++E+  G  + +   G++CGS  PE + S  +++ V+F SD+T++KKGF 
Sbjct: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697

Query: 971 LRYTSTK 977
             + S K
Sbjct: 698 AHFFSEK 704



 Score =  182 bits (457), Expect = 2e-44
 Identities = 90/230 (39%), Positives = 133/230 (57%), Gaps = 10/230 (4%)

Query: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
           C   +  ++G  +SP +P+ Y +   C W IS TPG ++ L F  +D+     C YD++E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRA 866
           V DG   KAP+ GRFCGSK PEP+++T SR+++ F S ++   KGF A +   CGG V+ 
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441

Query: 867 DVKTKDLYSHAQ---FGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYME 923
           D      Y H Q   + D+  P  V C W I   EG+ V L FQ+FE+E    C YDY+E
Sbjct: 442 D------YGHIQSPNYPDDYRPSKV-CIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494

Query: 924 LFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
           + DG+  ++  +GRYCG   P+++ S    + +KF SD +I K GF + +
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544



 Score =  179 bits (449), Expect = 1e-43
 Identities = 98/280 (35%), Positives = 140/280 (50%), Gaps = 45/280 (16%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG  ++   G+  SP YP+ Y     C+WRI V+ G  + L F S ++ R   C YDY+E
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
           VRDG    + L GR+CG + P+ I ST SRLW++F S  + + K  FAV           
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553

Query: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
                                             EA CGG + K  G I SP +P +Y P
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613

Query: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
           +K CIW++     + + L F  FE E +D C YD++EVR G +  S L G++CG EKP+ 
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673

Query: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRG 557
           I S  + + ++F SD +++K GF  +FF E     +P RG
Sbjct: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRG 713



>ref|NP_006119.1| bone morphogenetic protein 1, isoform 4, precursor; PCP [Homo
           sapiens]
 pir||A58788 procollagen C-endopeptidase (EC 3.4.24.19) precursor, splice form
           HIS - human
          Length = 823

 Score = 1409 bits (3607), Expect = 0.0
 Identities = 664/702 (94%), Positives = 664/702 (94%)

Query: 1   MPGVAXXXXXXXXXXXXXXXXXXDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
           MPGVA                  DLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60

Query: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXX 120
           EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQ               
Sbjct: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120

Query: 121 XXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
                PERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180

Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
           RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240

Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
           IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300

Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
           QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360

Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
           ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420

Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
           NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480

Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
           EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540

Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
           AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600

Query: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
           SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
Sbjct: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660

Query: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
           LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS
Sbjct: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702



 Score =  310 bits (786), Expect = 5e-83
 Identities = 160/422 (37%), Positives = 229/422 (53%), Gaps = 47/422 (11%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CG  ++   G+  SP YP+ Y     C+WRI V+ G  + L F S ++ R   C YDY+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553
           VRDG    + L GR+CG + P+ I ST SRLW++F S  + + K  FAV           
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431

Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
                                             EA CGG + K  G I SP +P +Y P
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457

Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
           +K CIW++     + + L F  FE E +D C YD++EVR G +  S L G++CG EKP+ 
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517

Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDN-GGCQQDCVNTFGSYECQCRSG 732
           I S  + + ++F SD +++K GF  +FF + DECS+ N GGC+Q C+NT GSY+C C  G
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577

Query: 733 FVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEM 792
           + L  +K  C EA C   +T  +G+ITSP WP +YP  K C W + +   +R+ L F   
Sbjct: 578 YELAPDKRRC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFF 636

Query: 793 DIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGF 852
           + E    C YD +EV  G  A + + G+FCGS+KPE + +  + M + F SDN+V +KGF
Sbjct: 637 ETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696

Query: 853 QA 854
           +A
Sbjct: 697 KA 698



 Score =  208 bits (525), Expect = 2e-52
 Identities = 126/425 (29%), Positives = 188/425 (43%), Gaps = 82/425 (19%)

Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
           ACG  L    G+ +SP +P  Y  + +C+W++      +I L F   +   + +C YD+V
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380

Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709
           EVR G    + L G+FCGS+ PE I S  + + VEF+S +    KGF A +         
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431

Query: 710 DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPS 769
                                             EA C   V    G I SPN+PD Y  
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457

Query: 770 KKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829
            K C W I  + G  V LTF   +IE    CAYD+LEV DG    + ++GR+CG +KP+ 
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517

Query: 830 VLATGSRMFLRFYSDNSVQRKGFQAS---HATECGGQVRADVKTKDLYSHAQF------- 879
           + +T SR++L+F SD S+ + GF  +      EC    R   + + L +   +       
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577

Query: 880 -----------------------------GDNNYPGGVDCEWVIVAEEGYGVELVFQTFE 910
                                            YP   +C W +VA   Y + L F  FE
Sbjct: 578 YELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637

Query: 911 VEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFH 970
            E    C YD++E+  G  + +   G++CGS  PE + S  +++ V+F SD+T++KKGF 
Sbjct: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697

Query: 971 LRYTS 975
             + S
Sbjct: 698 AHFFS 702



 Score =  182 bits (457), Expect = 2e-44
 Identities = 90/230 (39%), Positives = 133/230 (57%), Gaps = 10/230 (4%)

Query: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
           C   +  ++G  +SP +P+ Y +   C W IS TPG ++ L F  +D+     C YD++E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRA 866
           V DG   KAP+ GRFCGSK PEP+++T SR+++ F S ++   KGF A +   CGG V+ 
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441

Query: 867 DVKTKDLYSHAQ---FGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYME 923
           D      Y H Q   + D+  P  V C W I   EG+ V L FQ+FE+E    C YDY+E
Sbjct: 442 D------YGHIQSPNYPDDYRPSKV-CIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494

Query: 924 LFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
           + DG+  ++  +GRYCG   P+++ S    + +KF SD +I K GF + +
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544



 Score =  173 bits (435), Expect = 7e-42
 Identities = 94/272 (34%), Positives = 137/272 (49%), Gaps = 45/272 (16%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG  ++   G+  SP YP+ Y     C+WRI V+ G  + L F S ++ R   C YDY+E
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
           VRDG    + L GR+CG + P+ I ST SRLW++F S  + + K  FAV           
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553

Query: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
                                             EA CGG + K  G I SP +P +Y P
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613

Query: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
           +K CIW++     + + L F  FE E +D C YD++EVR G +  S L G++CG EKP+ 
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673

Query: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVD 549
           I S  + + ++F SD +++K GF  +FF  ++
Sbjct: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLE 705



 Score = 82.3 bits (200), Expect = 2e-14
 Identities = 41/117 (35%), Positives = 64/117 (54%)

Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
           ACG  L    G+ +SP +P  Y  + +C+W++      +I L F   +   + +C YD+V
Sbjct: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649

Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437
           EVR G    + L G+FCGS+ PE I S  + + VEF+S +    KGF A + ++  G
Sbjct: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEG 706



>ref|NP_006121.1| bone morphogenetic protein 1, isoform 4, precursor; PCP [Homo
           sapiens]
 emb|CAA69975.1| (Y08725) alternatively spliced transcript of BMP-1 gene [Homo
           sapiens]
          Length = 717

 Score = 1409 bits (3607), Expect = 0.0
 Identities = 664/702 (94%), Positives = 664/702 (94%)

Query: 1   MPGVAXXXXXXXXXXXXXXXXXXDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
           MPGVA                  DLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60

Query: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXX 120
           EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQ               
Sbjct: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120

Query: 121 XXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
                PERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180

Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
           RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240

Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
           IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300

Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
           QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360

Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
           ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420

Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
           NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480

Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
           EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540

Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600
           AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG 600

Query: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
           SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
Sbjct: 601 SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660

Query: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
           LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS
Sbjct: 661 LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702



 Score =  310 bits (786), Expect = 5e-83
 Identities = 160/422 (37%), Positives = 229/422 (53%), Gaps = 47/422 (11%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CG  ++   G+  SP YP+ Y     C+WRI V+ G  + L F S ++ R   C YDY+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553
           VRDG    + L GR+CG + P+ I ST SRLW++F S  + + K  FAV           
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431

Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
                                             EA CGG + K  G I SP +P +Y P
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457

Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
           +K CIW++     + + L F  FE E +D C YD++EVR G +  S L G++CG EKP+ 
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517

Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDN-GGCQQDCVNTFGSYECQCRSG 732
           I S  + + ++F SD +++K GF  +FF + DECS+ N GGC+Q C+NT GSY+C C  G
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577

Query: 733 FVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEM 792
           + L  +K  C EA C   +T  +G+ITSP WP +YP  K C W + +   +R+ L F   
Sbjct: 578 YELAPDKRRC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFF 636

Query: 793 DIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGF 852
           + E    C YD +EV  G  A + + G+FCGS+KPE + +  + M + F SDN+V +KGF
Sbjct: 637 ETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGF 696

Query: 853 QA 854
           +A
Sbjct: 697 KA 698



 Score =  208 bits (525), Expect = 2e-52
 Identities = 126/425 (29%), Positives = 188/425 (43%), Gaps = 82/425 (19%)

Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
           ACG  L    G+ +SP +P  Y  + +C+W++      +I L F   +   + +C YD+V
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380

Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709
           EVR G    + L G+FCGS+ PE I S  + + VEF+S +    KGF A +         
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431

Query: 710 DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPS 769
                                             EA C   V    G I SPN+PD Y  
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457

Query: 770 KKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829
            K C W I  + G  V LTF   +IE    CAYD+LEV DG    + ++GR+CG +KP+ 
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517

Query: 830 VLATGSRMFLRFYSDNSVQRKGFQAS---HATECGGQVRADVKTKDLYSHAQF------- 879
           + +T SR++L+F SD S+ + GF  +      EC    R   + + L +   +       
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577

Query: 880 -----------------------------GDNNYPGGVDCEWVIVAEEGYGVELVFQTFE 910
                                            YP   +C W +VA   Y + L F  FE
Sbjct: 578 YELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637

Query: 911 VEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFH 970
            E    C YD++E+  G  + +   G++CGS  PE + S  +++ V+F SD+T++KKGF 
Sbjct: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697

Query: 971 LRYTS 975
             + S
Sbjct: 698 AHFFS 702



 Score =  182 bits (457), Expect = 2e-44
 Identities = 90/230 (39%), Positives = 133/230 (57%), Gaps = 10/230 (4%)

Query: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
           C   +  ++G  +SP +P+ Y +   C W IS TPG ++ L F  +D+     C YD++E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRA 866
           V DG   KAP+ GRFCGSK PEP+++T SR+++ F S ++   KGF A +   CGG V+ 
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441

Query: 867 DVKTKDLYSHAQ---FGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYME 923
           D      Y H Q   + D+  P  V C W I   EG+ V L FQ+FE+E    C YDY+E
Sbjct: 442 D------YGHIQSPNYPDDYRPSKV-CIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494

Query: 924 LFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
           + DG+  ++  +GRYCG   P+++ S    + +KF SD +I K GF + +
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544



>emb|CAA70853.1| (Y09660) bone morphogenetic protein 1b [Xenopus laevis]
          Length = 735

 Score = 1208 bits (3091), Expect = 0.0
 Identities = 549/681 (80%), Positives = 613/681 (89%), Gaps = 12/681 (1%)

Query: 24  DLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSS 83
           +  DY+YDL EE   E ++YKDPCKAAAF GDIALDEEDL  F+V + VDL +HT   S+
Sbjct: 26  EFLDYSYDL-EEVVEESIDYKDPCKAAAFWGDIALDEEDLANFKVARIVDLTKHTI--ST 82

Query: 84  IKAAVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXXXXXXXPERVWPDGVIPFVIGGNF 143
           +  A   ++     + T  Q +                    PERVWPDGVIP+VI GNF
Sbjct: 83  VSGAASNSSRPQRGRRTRKQRRRSRERRAATSR---------PERVWPDGVIPYVISGNF 133

Query: 144 TGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGK 203
           +GSQRA+FRQAMRHWEKHTCVTFLERTDEDSYI+FTYRPCGCCSYVGRRGGGPQAISIGK
Sbjct: 134 SGSQRAIFRQAMRHWEKHTCVTFLERTDEDSYIIFTYRPCGCCSYVGRRGGGPQAISIGK 193

Query: 204 NCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGET 263
           NCDKFGIVVHELGHV+GFWHEHTRPDRD HVSI+RENIQPGQEYNFLKMEP+EVES+GET
Sbjct: 194 NCDKFGIVVHELGHVIGFWHEHTRPDRDDHVSIIRENIQPGQEYNFLKMEPEEVESIGET 253

Query: 264 YDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACG 323
           YDFDSIMHYARNTFSRGIFLDTI+PKY+VNGV+PPIGQRTRLS GDIAQA+KLY+CPACG
Sbjct: 254 YDFDSIMHYARNTFSRGIFLDTILPKYDVNGVRPPIGQRTRLSSGDIAQAKKLYRCPACG 313

Query: 324 ETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVR 383
           ETLQDS GNFSSP +PNGYSA+MHCVWR+SVTPGEKIILNFTSLDLYRSRLCWYDY+EVR
Sbjct: 314 ETLQDSQGNFSSPGFPNGYSAYMHCVWRLSVTPGEKIILNFTSLDLYRSRLCWYDYIEVR 373

Query: 384 DGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDY 443
           DGFW+KAPLRGRFCG K+PEPI+ST+SRLW+EFRSSSNWVGKGF AVYEA+CGGDVKKD 
Sbjct: 374 DGFWKKAPLRGRFCGDKIPEPIISTESRLWIEFRSSSNWVGKGFQAVYEALCGGDVKKDS 433

Query: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESS 503
           GHIQSPNYPDDYRP+K C+W++ VSEGFHVG++FQSFEIERHDSCAYDYLE+RDG SESS
Sbjct: 434 GHIQSPNYPDDYRPNKACVWKLSVSEGFHVGISFQSFEIERHDSCAYDYLEIRDGSSESS 493

Query: 504 TLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRC 563
            LIGR+CGY+KPDDIKS++++LW+KFVSDGSINKAGF++N+FKEVDECSRPN GGCEQRC
Sbjct: 494 PLIGRFCGYDKPDDIKSSTNQLWVKFVSDGSINKAGFSLNYFKEVDECSRPNNGGCEQRC 553

Query: 564 LNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVA 623
           +NTLGSYKC+CDPGYEL PDK+ CEAACGGFLTKLNGSITSPGWPKEYPPNKNC+WQLVA
Sbjct: 554 VNTLGSYKCACDPGYELGPDKKSCEAACGGFLTKLNGSITSPGWPKEYPPNKNCVWQLVA 613

Query: 624 PTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRV 683
           PTQYRISL+FD FETEGNDVCKYDFVEVRSGLT+DSKLHGKFCG+E P VITSQYNNMR+
Sbjct: 614 PTQYRISLKFDQFETEGNDVCKYDFVEVRSGLTSDSKLHGKFCGTELPAVITSQYNNMRI 673

Query: 684 EFKSDNTVSKKGFKAHFFSDK 704
           EFKSDNTVSKKGF+A+FFS+K
Sbjct: 674 EFKSDNTVSKKGFQANFFSEK 694



 Score =  313 bits (794), Expect = 5e-84
 Identities = 155/426 (36%), Positives = 232/426 (54%), Gaps = 45/426 (10%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CG  ++   G+  SP +P+ Y     C+WR+ V+ G  + L F S ++ R   C YDY+E
Sbjct: 312 CGETLQDSQGNFSSPGFPNGYSAYMHCVWRLSVTPGEKIILNFTSLDLYRSRLCWYDYIE 371

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
           VRDG  + + L GR+CG + P+ I ST SRLW++F S  +    GF   +          
Sbjct: 372 VRDGFWKKAPLRGRFCGDKIPEPIISTESRLWIEFRSSSNWVGKGFQAVY---------- 421

Query: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
                                            EA CGG + K +G I SP +P +Y PN
Sbjct: 422 ---------------------------------EALCGGDVKKDSGHIQSPNYPDDYRPN 448

Query: 615 KNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVI 674
           K C+W+L     + + + F  FE E +D C YD++E+R G +  S L G+FCG +KP+ I
Sbjct: 449 KACVWKLSVSEGFHVGISFQSFEIERHDSCAYDYLEIRDGSSESSPLIGRFCGYDKPDDI 508

Query: 675 TSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK-DNGGCQQDCVNTFGSYECQCRSGF 733
            S  N + V+F SD +++K GF  ++F + DECS+ +NGGC+Q CVNT GSY+C C  G+
Sbjct: 509 KSSTNQLWVKFVSDGSINKAGFSLNYFKEVDECSRPNNGGCEQRCVNTLGSYKCACDPGY 568

Query: 734 VLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMD 793
            L  +K  C EA C   +T  +G+ITSP WP +YP  K C W + +   +R+ L F + +
Sbjct: 569 ELGPDKKSC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCVWQLVAPTQYRISLKFDQFE 627

Query: 794 IESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQ 853
            E    C YD +EV  G  + + + G+FCG++ P  + +  + M + F SDN+V +KGFQ
Sbjct: 628 TEGNDVCKYDFVEVRSGLTSDSKLHGKFCGTELPAVITSQYNNMRIEFKSDNTVSKKGFQ 687

Query: 854 ASHATE 859
           A+  +E
Sbjct: 688 ANFFSE 693



 Score =  210 bits (530), Expect = 5e-53
 Identities = 127/431 (29%), Positives = 197/431 (45%), Gaps = 83/431 (19%)

Query: 586 RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
           RC A CG  L    G+ +SPG+P  Y    +C+W+L      +I L F   +   + +C 
Sbjct: 308 RCPA-CGETLQDSQGNFSSPGFPNGYSAYMHCVWRLSVTPGEKIILNFTSLDLYRSRLCW 366

Query: 646 YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKD 705
           YD++EVR G    + L G+FCG + PE I S  + + +EF+S +    KGF+A +     
Sbjct: 367 YDYIEVRDGFWKKAPLRGRFCGDKIPEPIISTESRLWIEFRSSSNWVGKGFQAVY----- 421

Query: 706 ECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPD 765
                                                 EA C   V   SG I SPN+PD
Sbjct: 422 --------------------------------------EALCGGDVKKDSGHIQSPNYPD 443

Query: 766 KYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSK 825
            Y   K C W +S + G  V ++F   +IE    CAYD+LE+ DG    +P++GRFCG  
Sbjct: 444 DYRPNKACVWKLSVSEGFHVGISFQSFEIERHDSCAYDYLEIRDGSSESSPLIGRFCGYD 503

Query: 826 KPEPVLATGSRMFLRFYSDNSVQRKGFQASH---ATEC-----GGQVRADVKTKDLYSHA 877
           KP+ + ++ ++++++F SD S+ + GF  ++     EC     GG  +  V T   Y  A
Sbjct: 504 KPDDIKSSTNQLWVKFVSDGSINKAGFSLNYFKEVDECSRPNNGGCEQRCVNTLGSYKCA 563

Query: 878 -----QFGDNN--------------------------YPGGVDCEWVIVAEEGYGVELVF 906
                + G +                           YP   +C W +VA   Y + L F
Sbjct: 564 CDPGYELGPDKKSCEAACGGFLTKLNGSITSPGWPKEYPPNKNCVWQLVAPTQYRISLKF 623

Query: 907 QTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITK 966
             FE E    C YD++E+  G  S +   G++CG+  P  + S  +++ ++F SD+T++K
Sbjct: 624 DQFETEGNDVCKYDFVEVRSGLTSDSKLHGKFCGTELPAVITSQYNNMRIEFKSDNTVSK 683

Query: 967 KGFHLRYTSTK 977
           KGF   + S K
Sbjct: 684 KGFQANFFSEK 694



 Score =  182 bits (456), Expect = 2e-44
 Identities = 87/229 (37%), Positives = 132/229 (56%), Gaps = 8/229 (3%)

Query: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
           C   +  + G  +SP +P+ Y +   C W +S TPG ++ L F  +D+     C YD++E
Sbjct: 312 CGETLQDSQGNFSSPGFPNGYSAYMHCVWRLSVTPGEKIILNFTSLDLYRSRLCWYDYIE 371

Query: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRA 866
           V DG   KAP+ GRFCG K PEP+++T SR+++ F S ++   KGFQA +   CGG V+ 
Sbjct: 372 VRDGFWKKAPLRGRFCGDKIPEPIISTESRLWIEFRSSSNWVGKGFQAVYEALCGGDVKK 431

Query: 867 DVKTKDLYSHAQFGD--NNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMEL 924
           D        H Q  +  ++Y     C W +   EG+ V + FQ+FE+E    C YDY+E+
Sbjct: 432 D------SGHIQSPNYPDDYRPNKACVWKLSVSEGFHVGISFQSFEIERHDSCAYDYLEI 485

Query: 925 FDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
            DG   ++P +GR+CG   P+++ S+ + + VKF SD +I K GF L Y
Sbjct: 486 RDGSSESSPLIGRFCGYDKPDDIKSSTNQLWVKFVSDGSINKAGFSLNY 534



 Score = 80.8 bits (196), Expect = 7e-14
 Identities = 41/121 (33%), Positives = 66/121 (53%)

Query: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
           ACG  L    G+ +SP +P  Y  + +CVW++      +I L F   +   + +C YD+V
Sbjct: 580 ACGGFLTKLNGSITSPGWPKEYPPNKNCVWQLVAPTQYRISLKFDQFETEGNDVCKYDFV 639

Query: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVK 440
           EVR G    + L G+FCG++LP  I S  + + +EF+S +    KGF A + +    +V+
Sbjct: 640 EVRSGLTSDSKLHGKFCGTELPAVITSQYNNMRIEFKSDNTVSKKGFQANFFSEKKNNVQ 699

Query: 441 K 441
           K
Sbjct: 700 K 700



>sp|P98070|BMP1_XENLA BONE MORPHOGENETIC PROTEIN 1 PRECURSOR (BMP-1)
 pir||JC2218 procollagen C-endopeptidase (EC 3.4.24.19) - African clawed frog
           (clone 22AN)
 gb|AAA16313.1| (L12249) bone morphogenic protein 1 [Xenopus laevis]
          Length = 707

 Score = 1199 bits (3069), Expect = 0.0
 Identities = 548/678 (80%), Positives = 605/678 (88%), Gaps = 12/678 (1%)

Query: 27  DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKA 86
           DY+YDL EE   E ++YKDPCKAAAF GDIALDEEDL  F++ + VDL +HT    S  A
Sbjct: 2   DYSYDL-EEVVEETIDYKDPCKAAAFWGDIALDEEDLANFKIDRIVDLTKHTIHTVSGAA 60

Query: 87  AVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXXXXXXXPERVWPDGVIPFVIGGNFTGS 146
               N S P         +                    PERVWPDGVIP+VI GNF+GS
Sbjct: 61  T---NISRPE--------KGRRTRKERRRSREKRASTSRPERVWPDGVIPYVISGNFSGS 109

Query: 147 QRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCD 206
           QRA+FRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCD
Sbjct: 110 QRAIFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCD 169

Query: 207 KFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDF 266
           KFGIVVHELGHV+GFWHEHTRPDRD HVSI+RENIQPGQEYNFLKMEP+EVESLGETYDF
Sbjct: 170 KFGIVVHELGHVIGFWHEHTRPDRDDHVSIIRENIQPGQEYNFLKMEPEEVESLGETYDF 229

Query: 267 DSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETL 326
           DSIMHYARNTFSRGIFLDTI+PKY+VNGV+PPIGQRTRLS GD+AQARKLYKCPACGETL
Sbjct: 230 DSIMHYARNTFSRGIFLDTILPKYDVNGVRPPIGQRTRLSSGDVAQARKLYKCPACGETL 289

Query: 327 QDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGF 386
           QDS GNFSSP +PNGYSA+MHCVWR+SVTPGEKIILNFTSLDLYRSRLCWYDY+EVRDGF
Sbjct: 290 QDSQGNFSSPGFPNGYSAYMHCVWRLSVTPGEKIILNFTSLDLYRSRLCWYDYIEVRDGF 349

Query: 387 WRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHI 446
           W+KAPLRGRFCG K+PE I+ST+SRLW+EFRSSSNWVGKGF AVYEA+CGG+VKKD GHI
Sbjct: 350 WKKAPLRGRFCGDKIPESIISTESRLWIEFRSSSNWVGKGFQAVYEALCGGEVKKDSGHI 409

Query: 447 QSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLI 506
           QSPNYPDDYRP+K C+W++ VSEGFHVG++FQSFEIERHDSCAYDYLE+RDG SE+S L+
Sbjct: 410 QSPNYPDDYRPNKACVWKLSVSEGFHVGISFQSFEIERHDSCAYDYLEIRDGSSETSPLV 469

Query: 507 GRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNT 566
           GR+CGY+KPDDIKS++++LW+KFVSDGSINKAGF++N+FKEVDECSRPN GGCEQRC+NT
Sbjct: 470 GRFCGYDKPDDIKSSTNQLWIKFVSDGSINKAGFSLNYFKEVDECSRPNNGGCEQRCVNT 529

Query: 567 LGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQ 626
           LGSYKC+CDPGYEL  DK+ CEAACGGFLTKLNGSI SPGWPKEYPPNKNCIWQLVAPTQ
Sbjct: 530 LGSYKCACDPGYELGQDKKSCEAACGGFLTKLNGSINSPGWPKEYPPNKNCIWQLVAPTQ 589

Query: 627 YRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFK 686
           YRISL+FD FETEGNDVCKYDFVEVRSGLT+DSKLHGKFCGSE P VITSQYNNMR+EFK
Sbjct: 590 YRISLKFDQFETEGNDVCKYDFVEVRSGLTSDSKLHGKFCGSELPAVITSQYNNMRIEFK 649

Query: 687 SDNTVSKKGFKAHFFSDK 704
           SDNTVSKKGF+A+FFS+K
Sbjct: 650 SDNTVSKKGFQANFFSEK 667



 Score =  312 bits (791), Expect = 1e-83
 Identities = 154/426 (36%), Positives = 231/426 (54%), Gaps = 45/426 (10%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CG  ++   G+  SP +P+ Y     C+WR+ V+ G  + L F S ++ R   C YDY+E
Sbjct: 285 CGETLQDSQGNFSSPGFPNGYSAYMHCVWRLSVTPGEKIILNFTSLDLYRSRLCWYDYIE 344

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
           VRDG  + + L GR+CG + P+ I ST SRLW++F S  +    GF   +          
Sbjct: 345 VRDGFWKKAPLRGRFCGDKIPESIISTESRLWIEFRSSSNWVGKGFQAVY---------- 394

Query: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
                                            EA CGG + K +G I SP +P +Y PN
Sbjct: 395 ---------------------------------EALCGGEVKKDSGHIQSPNYPDDYRPN 421

Query: 615 KNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVI 674
           K C+W+L     + + + F  FE E +D C YD++E+R G +  S L G+FCG +KP+ I
Sbjct: 422 KACVWKLSVSEGFHVGISFQSFEIERHDSCAYDYLEIRDGSSETSPLVGRFCGYDKPDDI 481

Query: 675 TSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK-DNGGCQQDCVNTFGSYECQCRSGF 733
            S  N + ++F SD +++K GF  ++F + DECS+ +NGGC+Q CVNT GSY+C C  G+
Sbjct: 482 KSSTNQLWIKFVSDGSINKAGFSLNYFKEVDECSRPNNGGCEQRCVNTLGSYKCACDPGY 541

Query: 734 VLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMD 793
            L  +K  C EA C   +T  +G+I SP WP +YP  K C W + +   +R+ L F + +
Sbjct: 542 ELGQDKKSC-EAACGGFLTKLNGSINSPGWPKEYPPNKNCIWQLVAPTQYRISLKFDQFE 600

Query: 794 IESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQ 853
            E    C YD +EV  G  + + + G+FCGS+ P  + +  + M + F SDN+V +KGFQ
Sbjct: 601 TEGNDVCKYDFVEVRSGLTSDSKLHGKFCGSELPAVITSQYNNMRIEFKSDNTVSKKGFQ 660

Query: 854 ASHATE 859
           A+  +E
Sbjct: 661 ANFFSE 666



 Score =  212 bits (533), Expect = 2e-53
 Identities = 126/427 (29%), Positives = 196/427 (45%), Gaps = 82/427 (19%)

Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
           ACG  L    G+ +SPG+P  Y    +C+W+L      +I L F   +   + +C YD++
Sbjct: 284 ACGETLQDSQGNFSSPGFPNGYSAYMHCVWRLSVTPGEKIILNFTSLDLYRSRLCWYDYI 343

Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709
           EVR G    + L G+FCG + PE I S  + + +EF+S +    KGF+A +         
Sbjct: 344 EVRDGFWKKAPLRGRFCGDKIPESIISTESRLWIEFRSSSNWVGKGFQAVY--------- 394

Query: 710 DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPS 769
                                             EA C  +V   SG I SPN+PD Y  
Sbjct: 395 ----------------------------------EALCGGEVKKDSGHIQSPNYPDDYRP 420

Query: 770 KKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829
            K C W +S + G  V ++F   +IE    CAYD+LE+ DG    +P++GRFCG  KP+ 
Sbjct: 421 NKACVWKLSVSEGFHVGISFQSFEIERHDSCAYDYLEIRDGSSETSPLVGRFCGYDKPDD 480

Query: 830 VLATGSRMFLRFYSDNSVQRKGFQASH---ATEC-----GGQVRADVKTKDLYSHA---- 877
           + ++ ++++++F SD S+ + GF  ++     EC     GG  +  V T   Y  A    
Sbjct: 481 IKSSTNQLWIKFVSDGSINKAGFSLNYFKEVDECSRPNNGGCEQRCVNTLGSYKCACDPG 540

Query: 878 -QFGDNN--------------------------YPGGVDCEWVIVAEEGYGVELVFQTFE 910
            + G +                           YP   +C W +VA   Y + L F  FE
Sbjct: 541 YELGQDKKSCEAACGGFLTKLNGSINSPGWPKEYPPNKNCIWQLVAPTQYRISLKFDQFE 600

Query: 911 VEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFH 970
            E    C YD++E+  G  S +   G++CGS  P  + S  +++ ++F SD+T++KKGF 
Sbjct: 601 TEGNDVCKYDFVEVRSGLTSDSKLHGKFCGSELPAVITSQYNNMRIEFKSDNTVSKKGFQ 660

Query: 971 LRYTSTK 977
             + S K
Sbjct: 661 ANFFSEK 667



 Score =  180 bits (452), Expect = 7e-44
 Identities = 86/229 (37%), Positives = 132/229 (57%), Gaps = 8/229 (3%)

Query: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
           C   +  + G  +SP +P+ Y +   C W +S TPG ++ L F  +D+     C YD++E
Sbjct: 285 CGETLQDSQGNFSSPGFPNGYSAYMHCVWRLSVTPGEKIILNFTSLDLYRSRLCWYDYIE 344

Query: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRA 866
           V DG   KAP+ GRFCG K PE +++T SR+++ F S ++   KGFQA +   CGG+V+ 
Sbjct: 345 VRDGFWKKAPLRGRFCGDKIPESIISTESRLWIEFRSSSNWVGKGFQAVYEALCGGEVKK 404

Query: 867 DVKTKDLYSHAQFGD--NNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMEL 924
           D        H Q  +  ++Y     C W +   EG+ V + FQ+FE+E    C YDY+E+
Sbjct: 405 D------SGHIQSPNYPDDYRPNKACVWKLSVSEGFHVGISFQSFEIERHDSCAYDYLEI 458

Query: 925 FDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
            DG   T+P +GR+CG   P+++ S+ + + +KF SD +I K GF L Y
Sbjct: 459 RDGSSETSPLVGRFCGYDKPDDIKSSTNQLWIKFVSDGSINKAGFSLNY 507



>gb|AAC02259.1| (U75331) bone morphogenetic protein 1 [Gallus gallus]
          Length = 691

 Score = 1174 bits (3004), Expect = 0.0
 Identities = 542/673 (80%), Positives = 590/673 (87%), Gaps = 35/673 (5%)

Query: 34  EEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTS 93
           EE++ E    +DPCKAAAFLGDIALDE+DLR F                       G+  
Sbjct: 30  EEEEEELRGSRDPCKAAAFLGDIALDEDDLRHF-----------------------GSPP 66

Query: 94  TPSCQSTNGQPQXXXXXXXXXXXXXXXXXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQ 153
            P     +  P+                    PERVWPDGVIP+VI GNF+GSQRAVFRQ
Sbjct: 67  PPPPPRGSAPPRRRRAATSR------------PERVWPDGVIPYVISGNFSGSQRAVFRQ 114

Query: 154 AMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVH 213
           AMRHWE+HTCVTFLER+DEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVH
Sbjct: 115 AMRHWERHTCVTFLERSDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVH 174

Query: 214 ELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYA 273
           ELGHV+GFWHEHTRPDRD HV+I+R+NIQPGQEYNFLKMEP EVESLGETYDFDSIMHYA
Sbjct: 175 ELGHVIGFWHEHTRPDRDHHVAIIRDNIQPGQEYNFLKMEPDEVESLGETYDFDSIMHYA 234

Query: 274 RNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNF 333
           RNTFSRGIFLDTI+PKY++NGV+P IGQRTRLSKGDIAQARKLY+CPACGETLQDS GNF
Sbjct: 235 RNTFSRGIFLDTILPKYDINGVRPSIGQRTRLSKGDIAQARKLYRCPACGETLQDSHGNF 294

Query: 334 SSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLR 393
           SSP++PNGY+AHMHCVWRISVTPGEKI LNFT+LD+YRSRLCWYDYVEVRDGFWRKA LR
Sbjct: 295 SSPQFPNGYAAHMHCVWRISVTPGEKIQLNFTALDVYRSRLCWYDYVEVRDGFWRKAALR 354

Query: 394 GRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPD 453
           GRFCG+KLPEPIVS+DSRLWVEFRSSSNWVGKGFFAVYEAICGGDV KD GHIQSPNYPD
Sbjct: 355 GRFCGNKLPEPIVSSDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVHKDSGHIQSPNYPD 414

Query: 454 DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYE 513
           DYRPSKVC+WRI V+EGFHVGL+FQ+FEIERHDSCAYDYLEVRDG SES  LIGR+CGYE
Sbjct: 415 DYRPSKVCVWRIAVAEGFHVGLSFQAFEIERHDSCAYDYLEVRDGGSESGALIGRFCGYE 474

Query: 514 KPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCS 573
           KPDDIKS S+RLWLKFVSDGSINKAGFAV+FFKEVDECSRPN GGCEQRC+NTLGSYKC 
Sbjct: 475 KPDDIKSASNRLWLKFVSDGSINKAGFAVSFFKEVDECSRPNNGGCEQRCINTLGSYKCG 534

Query: 574 CDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQF 633
           C+PGYELA D+RRCEAACGGFLTKLNGSI+SPGWP++YPPNK+C+WQLVAPTQYRISL+F
Sbjct: 535 CEPGYELAADRRRCEAACGGFLTKLNGSISSPGWPRDYPPNKHCVWQLVAPTQYRISLRF 594

Query: 634 DFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSK 693
           DFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCG   P  ITSQYNNMRVEF+S NTV+K
Sbjct: 595 DFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGGGLPGAITSQYNNMRVEFRSYNTVAK 654

Query: 694 KGFKAHFFSDKDE 706
           +GFKAHFFS+K +
Sbjct: 655 RGFKAHFFSEKKQ 667



 Score =  296 bits (751), Expect = 6e-79
 Identities = 151/427 (35%), Positives = 226/427 (52%), Gaps = 47/427 (11%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CG  ++  +G+  SP +P+ Y     C+WRI V+ G  + L F + ++ R   C YDY+E
Sbjct: 283 CGETLQDSHGNFSSPQFPNGYAAHMHCVWRISVTPGEKIQLNFTALDVYRSRLCWYDYVE 342

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553
           VRDG    + L GR+CG + P+ I S+ SRLW++F S  + + K  FAV           
Sbjct: 343 VRDGFWRKAALRGRFCGNKLPEPIVSSDSRLWVEFRSSSNWVGKGFFAVY---------- 392

Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
                                             EA CGG + K +G I SP +P +Y P
Sbjct: 393 ----------------------------------EAICGGDVHKDSGHIQSPNYPDDYRP 418

Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
           +K C+W++     + + L F  FE E +D C YD++EVR G +    L G+FCG EKP+ 
Sbjct: 419 SKVCVWRIAVAEGFHVGLSFQAFEIERHDSCAYDYLEVRDGGSESGALIGRFCGYEKPDD 478

Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK-DNGGCQQDCVNTFGSYECQCRSG 732
           I S  N + ++F SD +++K GF   FF + DECS+ +NGGC+Q C+NT GSY+C C  G
Sbjct: 479 IKSASNRLWLKFVSDGSINKAGFAVSFFKEVDECSRPNNGGCEQRCINTLGSYKCGCEPG 538

Query: 733 FVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEM 792
           + L  ++  C EA C   +T  +G+I+SP WP  YP  K C W + +   +R+ L F   
Sbjct: 539 YELAADRRRC-EAACGGFLTKLNGSISSPGWPRDYPPNKHCVWQLVAPTQYRISLRFDFF 597

Query: 793 DIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGF 852
           + E    C YD +EV  G  A + + G+FCG   P  + +  + M + F S N+V ++GF
Sbjct: 598 ETEGNDVCKYDFVEVRSGLTADSKLHGKFCGGGLPGAITSQYNNMRVEFRSYNTVAKRGF 657

Query: 853 QASHATE 859
           +A   +E
Sbjct: 658 KAHFFSE 664



 Score =  204 bits (514), Expect = 4e-51
 Identities = 130/433 (30%), Positives = 191/433 (44%), Gaps = 83/433 (19%)

Query: 586 RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
           RC A CG  L   +G+ +SP +P  Y  + +C+W++      +I L F   +   + +C 
Sbjct: 279 RCPA-CGETLQDSHGNFSSPQFPNGYAAHMHCVWRISVTPGEKIQLNFTALDVYRSRLCW 337

Query: 646 YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKD 705
           YD+VEVR G    + L G+FCG++ PE I S  + + VEF+S +    KGF A +     
Sbjct: 338 YDYVEVRDGFWRKAALRGRFCGNKLPEPIVSSDSRLWVEFRSSSNWVGKGFFAVY----- 392

Query: 706 ECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPD 765
                                                 EA C   V   SG I SPN+PD
Sbjct: 393 --------------------------------------EAICGGDVHKDSGHIQSPNYPD 414

Query: 766 KYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSK 825
            Y   K C W I+   G  V L+F   +IE    CAYD+LEV DG      ++GRFCG +
Sbjct: 415 DYRPSKVCVWRIAVAEGFHVGLSFQAFEIERHDSCAYDYLEVRDGGSESGALIGRFCGYE 474

Query: 826 KPEPVLATGSRMFLRFYSDNSVQRKGFQAS---HATEC-----GGQVRADVKTKDLYS-- 875
           KP+ + +  +R++L+F SD S+ + GF  S      EC     GG  +  + T   Y   
Sbjct: 475 KPDDIKSASNRLWLKFVSDGSINKAGFAVSFFKEVDECSRPNNGGCEQRCINTLGSYKCG 534

Query: 876 --------------HAQFGD---------------NNYPGGVDCEWVIVAEEGYGVELVF 906
                          A  G                 +YP    C W +VA   Y + L F
Sbjct: 535 CEPGYELAADRRRCEAACGGFLTKLNGSISSPGWPRDYPPNKHCVWQLVAPTQYRISLRF 594

Query: 907 QTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITK 966
             FE E    C YD++E+  G  + +   G++CG G P  + S  +++ V+F S +T+ K
Sbjct: 595 DFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGGGLPGAITSQYNNMRVEFRSYNTVAK 654

Query: 967 KGFHLRYTSTKFQ 979
           +GF   + S K Q
Sbjct: 655 RGFKAHFFSEKKQ 667



 Score =  169 bits (425), Expect = 1e-40
 Identities = 84/227 (37%), Positives = 127/227 (55%), Gaps = 4/227 (1%)

Query: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
           C   +  + G  +SP +P+ Y +   C W IS TPG +++L F  +D+     C YD++E
Sbjct: 283 CGETLQDSHGNFSSPQFPNGYAAHMHCVWRISVTPGEKIQLNFTALDVYRSRLCWYDYVE 342

Query: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRA 866
           V DG   KA + GRFCG+K PEP++++ SR+++ F S ++   KGF A +   CGG V  
Sbjct: 343 VRDGFWRKAALRGRFCGNKLPEPIVSSDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVHK 402

Query: 867 DVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFD 926
           D           + D+  P  V C W I   EG+ V L FQ FE+E    C YDY+E+ D
Sbjct: 403 D---SGHIQSPNYPDDYRPSKV-CVWRIAVAEGFHVGLSFQAFEIERHDSCAYDYLEVRD 458

Query: 927 GYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
           G   +   +GR+CG   P+++ SA + + +KF SD +I K GF + +
Sbjct: 459 GGSESGALIGRFCGYEKPDDIKSASNRLWLKFVSDGSINKAGFAVSF 505



 Score =  162 bits (407), Expect = 1e-38
 Identities = 92/277 (33%), Positives = 133/277 (47%), Gaps = 45/277 (16%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           CG  +   +G+  SP YP+ Y     CVWRI+V  G  + L+F + ++ R   C YDY+E
Sbjct: 396 CGGDVHKDSGHIQSPNYPDDYRPSKVCVWRIAVAEGFHVGLSFQAFEIERHDSCAYDYLE 455

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
           VRDG      L GRFCG + P+ I S  +RLW++F S  + + K  FAV           
Sbjct: 456 VRDGGSESGALIGRFCGYEKPDDIKSASNRLWLKFVSDGS-INKAGFAVSFFKEVDECSR 514

Query: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
                                             EA CGG + K  G I SP +P DY P
Sbjct: 515 PNNGGCEQRCINTLGSYKCGCEPGYELAADRRRCEAACGGFLTKLNGSISSPGWPRDYPP 574

Query: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
           +K C+W++     + + L F  FE E +D C YD++EVR G +  S L G++CG   P  
Sbjct: 575 NKHCVWQLVAPTQYRISLRFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGGGLPGA 634

Query: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
           I S  + + ++F S  ++ K GF  +FF E  +  +P
Sbjct: 635 ITSQYNNMRVEFRSYNTVAKRGFKAHFFSEKKQQLQP 671



>ref|NP_006122.1| bone morphogenetic protein 1, isoform 4, precursor; PCP [Homo
           sapiens]
 emb|CAA69974.1| (Y08724) alternatively spliced transcript of BMP-1 gene [Homo
           sapiens]
          Length = 622

 Score = 1166 bits (2984), Expect = 0.0
 Identities = 550/588 (93%), Positives = 550/588 (93%)

Query: 1   MPGVAXXXXXXXXXXXXXXXXXXDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60
           MPGVA                  DLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
Sbjct: 1   MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE 60

Query: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXX 120
           EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQ               
Sbjct: 61  EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR 120

Query: 121 XXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180
                PERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
Sbjct: 121 AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY 180

Query: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240
           RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
Sbjct: 181 RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN 240

Query: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
           IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
Sbjct: 241 IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300

Query: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360
           QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
Sbjct: 301 QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI 360

Query: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420
           ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
Sbjct: 361 ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS 420

Query: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480
           NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
Sbjct: 421 NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF 480

Query: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540
           EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
Sbjct: 481 EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF 540

Query: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588
           AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE
Sbjct: 541 AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588



 Score =  221 bits (557), Expect = 3e-56
 Identities = 117/315 (37%), Positives = 166/315 (52%), Gaps = 48/315 (15%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CG  ++   G+  SP YP+ Y     C+WRI V+ G  + L F S ++ R   C YDY+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGS-INKAGFAVNFFKEVDECSR 553
           VRDG    + L GR+CG + P+ I ST SRLW++F S  + + K  FAV           
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431

Query: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
                                             EA CGG + K  G I SP +P +Y P
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457

Query: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
           +K CIW++     + + L F  FE E +D C YD++EVR G +  S L G++CG EKP+ 
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517

Query: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDN-GGCQQDCVNTFGSYECQCRSG 732
           I S  + + ++F SD +++K GF  +FF + DECS+ N GGC+Q C+NT GSY+C C  G
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577

Query: 733 FVLHDNKHDCKEAGC 747
           + L  +K  C+  GC
Sbjct: 578 YELAPDKRRCE--GC 590



 Score =  182 bits (457), Expect = 2e-44
 Identities = 90/230 (39%), Positives = 133/230 (57%), Gaps = 10/230 (4%)

Query: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
           C   +  ++G  +SP +P+ Y +   C W IS TPG ++ L F  +D+     C YD++E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381

Query: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRA 866
           V DG   KAP+ GRFCGSK PEP+++T SR+++ F S ++   KGF A +   CGG V+ 
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441

Query: 867 DVKTKDLYSHAQ---FGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYME 923
           D      Y H Q   + D+  P  V C W I   EG+ V L FQ+FE+E    C YDY+E
Sbjct: 442 D------YGHIQSPNYPDDYRPSKV-CIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494

Query: 924 LFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
           + DG+  ++  +GRYCG   P+++ S    + +KF SD +I K GF + +
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544



 Score =  161 bits (402), Expect = 5e-38
 Identities = 89/270 (32%), Positives = 128/270 (46%), Gaps = 43/270 (15%)

Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
           ACG  L    G+ +SP +P  Y  + +C+W++      +I L F   +   + +C YD+V
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380

Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709
           EVR G    + L G+FCGS+ PE I S  + + VEF+S +    KGF A +         
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431

Query: 710 DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPS 769
                                             EA C   V    G I SPN+PD Y  
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457

Query: 770 KKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829
            K C W I  + G  V LTF   +IE    CAYD+LEV DG    + ++GR+CG +KP+ 
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517

Query: 830 VLATGSRMFLRFYSDNSVQRKGFQASHATE 859
           + +T SR++L+F SD S+ + GF  +   E
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKE 547



>gb|AAF56328.1| (AE003749) tok gene product [Drosophila melanogaster]
          Length = 1464

 Score =  946 bits (2419), Expect = 0.0
 Identities = 439/866 (50%), Positives = 594/866 (67%), Gaps = 18/866 (2%)

Query: 127  ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDE--DSYIVFTYRPCG 184
            ER+W  GVIP+ I GNF+G  +A+F+ AMRHWE  TC+ F+ER  E   +YIVFT R CG
Sbjct: 526  ERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCG 585

Query: 185  CCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPG 244
            CCS+VG+RG GPQAISIG+NCDKFGIVVHELGHVVGFWHEHTRPDR++HV I   NI  G
Sbjct: 586  CCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKG 645

Query: 245  QEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTR 304
            Q+YNF  + P EV+SLG  YD+DSIMHYARNTFS+G +LDTI+P       +P IGQR R
Sbjct: 646  QDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLR 705

Query: 305  LSKGDIAQARKLYKCPACGETLQDSTGNFSSPE-YPNGYSAHM--HCVWRISVTPGEKII 361
            LS+GDIAQA  LYKCP CG T Q+S+G F+SP  Y  G  ++   HC WRI+ T GE++ 
Sbjct: 706  LSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRITATYGERVE 765

Query: 362  LNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSN 421
            L   ++++++S  C  DY+E+RDG++ K+PL GRFCG    E I +  SR+ + + ++  
Sbjct: 766  LKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHR 825

Query: 422  WVG-KGFFAVYEAICGGDVKKD--YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQ 478
              G +GF A ++ +CGG++  D   G ++SPNYP DY P+K C+W+I V E + V L FQ
Sbjct: 826  IEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQ 885

Query: 479  SFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKA 538
            SFE+E HDSC YDY+EVRDG  + + LIG +CGY+ P ++KS+ + +++KFVSD S+ KA
Sbjct: 886  SFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKA 945

Query: 539  GFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL 598
            GF+  F KEVDEC   N G CE  C+NTLG Y+CSC  G+EL  DK+ CE ACGG +   
Sbjct: 946  GFSAVFMKEVDECETQNHG-CEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYP 1004

Query: 599  NGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN----DVCKYDFVEVRSG 654
            NG+ITSP +P+ YP  K CIW++VAP ++RISL F  F+ EG       C YD V V S 
Sbjct: 1005 NGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSK 1064

Query: 655  LTADS-KLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGG 713
            L  +  K  G FCGS  P   TS+ N +R+EF SD ++ + GF A FF+D DEC+ +NGG
Sbjct: 1065 LGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGG 1124

Query: 714  CQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKEC 773
            CQ +C NT GSY C C +G+ +H+N HDCKE  C +++++  GTI SPN+PD YP   +C
Sbjct: 1125 CQHECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADC 1184

Query: 774  TWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLAT 833
             W   +TPGHR+KL F E D+ES  EC YD++ V+DG    + VLGRFCG K P P+ +T
Sbjct: 1185 VWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISST 1244

Query: 834  GSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWV 893
             ++M++   +D + Q+ GF ASH+T CGG +RA  + +  YSHA+FG+ +Y  G+DCEW 
Sbjct: 1245 SNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQDYDDGMDCEWT 1304

Query: 894  IVAEEGYGVELVFQTFEVEEETDCGYDYMELF----DGYDSTAPRLGRYCGSGPPEEVYS 949
            I A +   V+L+F TF++E   +C +DY+++F    D Y    P  G+YCG+  P+++ S
Sbjct: 1305 IAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQDINS 1364

Query: 950  AGDSVLVKFHSDDTITKKGFHLRYTS 975
               S+LV+F +D ++  KGF   Y +
Sbjct: 1365 MTHSLLVRFKTDGSVPMKGFSASYVA 1390



 Score = 60.1 bits (143), Expect = 1e-07
 Identities = 35/110 (31%), Positives = 55/110 (49%), Gaps = 8/110 (7%)

Query: 329  STGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEV----RD 384
            S   F + +Y +G    M C W I+      + L F + D+  S  C +DYV+V     D
Sbjct: 1286 SHARFGNQDYDDG----MDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDD 1341

Query: 385  GFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
             + +  P+ G++CG+ LP+ I S    L V F++  +   KGF A Y A+
Sbjct: 1342 VYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASYVAV 1391



>pir||S58984 development protein tolkin (EC 3.4.24.-) - fruit fly (Drosophila
            melanogaster)
 gb|AAC47015.1| (U34777) tolloid homolog; Method: conceptual translation supplied by
            author [Drosophila melanogaster]
          Length = 1464

 Score =  946 bits (2419), Expect = 0.0
 Identities = 439/866 (50%), Positives = 594/866 (67%), Gaps = 18/866 (2%)

Query: 127  ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDE--DSYIVFTYRPCG 184
            ER+W  GVIP+ I GNF+G  +A+F+ AMRHWE  TC+ F+ER  E   +YIVFT R CG
Sbjct: 526  ERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCG 585

Query: 185  CCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPG 244
            CCS+VG+RG GPQAISIG+NCDKFGIVVHELGHVVGFWHEHTRPDR++HV I   NI  G
Sbjct: 586  CCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKG 645

Query: 245  QEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTR 304
            Q+YNF  + P EV+SLG  YD+DSIMHYARNTFS+G +LDTI+P       +P IGQR R
Sbjct: 646  QDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLR 705

Query: 305  LSKGDIAQARKLYKCPACGETLQDSTGNFSSPE-YPNGYSAHM--HCVWRISVTPGEKII 361
            LS+GDIAQA  LYKCP CG T Q+S+G F+SP  Y  G  ++   HC WRI+ T GE++ 
Sbjct: 706  LSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRITATYGERVE 765

Query: 362  LNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSN 421
            L   ++++++S  C  DY+E+RDG++ K+PL GRFCG    E I +  SR+ + + ++  
Sbjct: 766  LKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHR 825

Query: 422  WVG-KGFFAVYEAICGGDVKKD--YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQ 478
              G +GF A ++ +CGG++  D   G ++SPNYP DY P+K C+W+I V E + V L FQ
Sbjct: 826  IEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQ 885

Query: 479  SFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKA 538
            SFE+E HDSC YDY+EVRDG  + + LIG +CGY+ P ++KS+ + +++KFVSD S+ KA
Sbjct: 886  SFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKA 945

Query: 539  GFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL 598
            GF+  F KEVDEC   N G CE  C+NTLG Y+CSC  G+EL  DK+ CE ACGG +   
Sbjct: 946  GFSAVFMKEVDECETQNHG-CEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYP 1004

Query: 599  NGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN----DVCKYDFVEVRSG 654
            NG+ITSP +P+ YP  K CIW++VAP ++RISL F  F+ EG       C YD V V S 
Sbjct: 1005 NGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSK 1064

Query: 655  LTADS-KLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGG 713
            L  +  K  G FCGS  P   TS+ N +R+EF SD ++ + GF A FF+D DEC+ +NGG
Sbjct: 1065 LGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGG 1124

Query: 714  CQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKEC 773
            CQ +C NT GSY C C +G+ +H+N HDCKE  C +++++  GTI SPN+PD YP   +C
Sbjct: 1125 CQHECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADC 1184

Query: 774  TWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLAT 833
             W   +TPGHR+KL F E D+ES  EC YD++ V+DG    + VLGRFCG K P P+ +T
Sbjct: 1185 VWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISST 1244

Query: 834  GSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWV 893
             ++M++   +D + Q+ GF ASH+T CGG +RA  + +  YSHA+FG+ +Y  G+DCEW 
Sbjct: 1245 SNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQDYDDGMDCEWT 1304

Query: 894  IVAEEGYGVELVFQTFEVEEETDCGYDYMELF----DGYDSTAPRLGRYCGSGPPEEVYS 949
            I A +   V+L+F TF++E   +C +DY+++F    D Y    P  G+YCG+  P+++ S
Sbjct: 1305 IAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQDINS 1364

Query: 950  AGDSVLVKFHSDDTITKKGFHLRYTS 975
               S+LV+F +D ++  KGF   Y +
Sbjct: 1365 MTHSLLVRFKTDGSVPMKGFSASYVA 1390



 Score = 60.1 bits (143), Expect = 1e-07
 Identities = 35/110 (31%), Positives = 55/110 (49%), Gaps = 8/110 (7%)

Query: 329  STGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEV----RD 384
            S   F + +Y +G    M C W I+      + L F + D+  S  C +DYV+V     D
Sbjct: 1286 SHARFGNQDYDDG----MDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDD 1341

Query: 385  GFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
             + +  P+ G++CG+ LP+ I S    L V F++  +   KGF A Y A+
Sbjct: 1342 VYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASYVAV 1391



>gb|AAA70057.1| (U12634) tolloid related-1 [Drosophila melanogaster]
          Length = 1464

 Score =  946 bits (2419), Expect = 0.0
 Identities = 439/866 (50%), Positives = 594/866 (67%), Gaps = 18/866 (2%)

Query: 127  ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDE--DSYIVFTYRPCG 184
            ER+W  GVIP+ I GNF+G  +A+F+ AMRHWE  TC+ F+ER  E   +YIVFT R CG
Sbjct: 526  ERIWDYGVIPYEIDGNFSGIHKALFKLAMRHWENSTCIKFVERDPEIHPNYIVFTVRSCG 585

Query: 185  CCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPG 244
            CCS+VG+RG GPQAISIG+NCDKFGIVVHELGHVVGFWHEHTRPDR++HV I   NI  G
Sbjct: 586  CCSFVGKRGNGPQAISIGRNCDKFGIVVHELGHVVGFWHEHTRPDREKHVVIEHNNIMKG 645

Query: 245  QEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTR 304
            Q+YNF  + P EV+SLG  YD+DSIMHYARNTFS+G +LDTI+P       +P IGQR R
Sbjct: 646  QDYNFNMLSPDEVDSLGMAYDYDSIMHYARNTFSKGTYLDTILPIEMKGRKRPEIGQRLR 705

Query: 305  LSKGDIAQARKLYKCPACGETLQDSTGNFSSPE-YPNGYSAHM--HCVWRISVTPGEKII 361
            LS+GDIAQA  LYKCP CG T Q+S+G F+SP  Y  G  ++   HC WRI+ T GE++ 
Sbjct: 706  LSQGDIAQANLLYKCPKCGRTFQESSGIFASPSHYTAGALSNETEHCEWRITATYGERVE 765

Query: 362  LNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSN 421
            L   ++++++S  C  DY+E+RDG++ K+PL GRFCG    E I +  SR+ + + ++  
Sbjct: 766  LKLENMNIFKSNNCETDYLEIRDGYFEKSPLIGRFCGKVDKEVIRTESSRMLLTYVNTHR 825

Query: 422  WVG-KGFFAVYEAICGGDVKKD--YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQ 478
              G +GF A ++ +CGG++  D   G ++SPNYP DY P+K C+W+I V E + V L FQ
Sbjct: 826  IEGFRGFKAEFDVVCGGELSVDDAVGRLESPNYPLDYLPNKECVWKITVPESYQVALKFQ 885

Query: 479  SFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKA 538
            SFE+E HDSC YDY+EVRDG  + + LIG +CGY+ P ++KS+ + +++KFVSD S+ KA
Sbjct: 886  SFEVENHDSCVYDYVEVRDGPGQDAPLIGVFCGYKPPPNMKSSGNSMYVKFVSDTSVQKA 945

Query: 539  GFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKL 598
            GF+  F KEVDEC   N G CE  C+NTLG Y+CSC  G+EL  DK+ CE ACGG +   
Sbjct: 946  GFSAVFMKEVDECETQNHG-CEHECINTLGGYECSCRIGFELHSDKKHCEDACGGVIEYP 1004

Query: 599  NGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN----DVCKYDFVEVRSG 654
            NG+ITSP +P+ YP  K CIW++VAP ++RISL F  F+ EG       C YD V V S 
Sbjct: 1005 NGTITSPSFPEMYPLLKECIWEIVAPPKHRISLNFTHFDLEGTAHQQSDCGYDSVTVYSK 1064

Query: 655  LTADS-KLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGG 713
            L  +  K  G FCGS  P   TS+ N +R+EF SD ++ + GF A FF+D DEC+ +NGG
Sbjct: 1065 LGENRLKRIGTFCGSSIPPTATSESNALRLEFHSDKSIQRSGFAAVFFTDIDECAVNNGG 1124

Query: 714  CQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKEC 773
            CQ +C NT GSY C C +G+ +H+N HDCKE  C +++++  GTI SPN+PD YP   +C
Sbjct: 1125 CQHECRNTIGSYICMCHNGYSMHENGHDCKEGECKYEISAPFGTIFSPNYPDSYPPNADC 1184

Query: 774  TWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLAT 833
             W   +TPGHR+KL F E D+ES  EC YD++ V+DG    + VLGRFCG K P P+ +T
Sbjct: 1185 VWHFITTPGHRIKLIFNEFDVESHQECTYDNVAVYDGESESSSVLGRFCGDKIPFPISST 1244

Query: 834  GSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWV 893
             ++M++   +D + Q+ GF ASH+T CGG +RA  + +  YSHA+FG+ +Y  G+DCEW 
Sbjct: 1245 SNQMYMVLKTDKNKQKNGFTASHSTACGGYLRATSQVQQFYSHARFGNQDYDDGMDCEWT 1304

Query: 894  IVAEEGYGVELVFQTFEVEEETDCGYDYMELF----DGYDSTAPRLGRYCGSGPPEEVYS 949
            I A +   V+L+F TF++E   +C +DY+++F    D Y    P  G+YCG+  P+++ S
Sbjct: 1305 IAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDDVYGQYGPMYGQYCGNVLPQDINS 1364

Query: 950  AGDSVLVKFHSDDTITKKGFHLRYTS 975
               S+LV+F +D ++  KGF   Y +
Sbjct: 1365 MTHSLLVRFKTDGSVPMKGFSASYVA 1390



 Score = 60.1 bits (143), Expect = 1e-07
 Identities = 35/110 (31%), Positives = 55/110 (49%), Gaps = 8/110 (7%)

Query: 329  STGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEV----RD 384
            S   F + +Y +G    M C W I+      + L F + D+  S  C +DYV+V     D
Sbjct: 1286 SHARFGNQDYDDG----MDCEWTIAAPDNSYVQLIFLTFDIESSENCTFDYVQVFSDIDD 1341

Query: 385  GFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI 434
             + +  P+ G++CG+ LP+ I S    L V F++  +   KGF A Y A+
Sbjct: 1342 VYGQYGPMYGQYCGNVLPQDINSMTHSLLVRFKTDGSVPMKGFSASYVAV 1391



>pir||T31069 tolloid-BMP-1 like protein 1 - California sea hare
 gb|AAC47485.1| (U57369) TBL-1 [Aplysia californica]
          Length = 1070

 Score =  843 bits (2154), Expect = 0.0
 Identities = 404/916 (44%), Positives = 567/916 (61%), Gaps = 25/916 (2%)

Query: 69   QQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQXXXXXXXXXXXXXXXXXXXXPER 128
            ++ + LR H  RK  ++     +   P   S+ G+ +                      +
Sbjct: 173  RKQIKLRLHRLRKEIVQGDENESDGRPHSSSSRGRHRRATPADRS--------------K 218

Query: 129  VWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDS-YIVFTYRPCGCCS 187
            +W  GVIP+VI  N++G  + +F+ AMRHWE  TC+ F ++  ED+ YI+FT   CGCCS
Sbjct: 219  LWDHGVIPYVIESNYSGENKDLFKLAMRHWENLTCLVFKDKGPEDTNYILFTQTDCGCCS 278

Query: 188  YVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEY 247
            +VG+ G G Q IS+GK C  FG VVHELGHVVGFWHEH RPDRD++V I+R+NI PG+E 
Sbjct: 279  FVGKHGSGAQVISLGKGCYYFGTVVHELGHVVGFWHEHNRPDRDKYVQIIRKNIMPGKES 338

Query: 248  NFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVK-PPIGQRTRLS 306
             F  ++  +V+SLGE YD+ SIMHY+R+ FS+  +LDTI P  +   +  P IGQ  RL+
Sbjct: 339  EFNILDEDKVDSLGEPYDYGSIMHYSRDKFSKHSYLDTIRPFRQRGMIALPRIGQNIRLN 398

Query: 307  KGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS 366
             GD+ Q  KLYKCP CG T+ +S G  S     +G      C WRI  + GE+I L+ T 
Sbjct: 399  DGDVRQTNKLYKCPTCGRTVMESKGTISPD---SGIRGEKTCQWRIIASHGERIQLSLTR 455

Query: 367  LDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKG 426
            LDL     C  DYVEVRDG +  +   G+FCG K+P P++S+ +RLWVE++S +    + 
Sbjct: 456  LDLSN---CDTDYVEVRDGHFVGSLSLGKFCGKKIPPPMISSGTRLWVEYKSRAAR-REA 511

Query: 427  FFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD 486
            F A +EAICGG++    G + SP YPD+Y   KVC W I V EG+ V L F +FE E   
Sbjct: 512  FQAAFEAICGGNMPGPEGFLNSPAYPDEYGSDKVCEWVITVREGYQVALEFATFETEFDP 571

Query: 487  SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK 546
             CAYDY+E+RDG ++ S L+G YCG   P +  STS  L++KFVSD S+ K GF+ ++ +
Sbjct: 572  DCAYDYVEIRDGDTKDSPLVGTYCGTRTPPNAISTSRHLYVKFVSDESMQKGGFSASYLE 631

Query: 547  EVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPG 606
            EVDEC   + G CE  C+NTLGSY+C+C  GYEL  D ++CE ACGG+L   +G+I+SP 
Sbjct: 632  EVDECEGEDHG-CEHVCVNTLGSYECTCKIGYELHSDGKKCEKACGGYLDAPSGTISSPS 690

Query: 607  WPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGN-DVCKYDFVEVRSGLTADSKLHGKF 665
            +P  YPP+KNC+W + AP  + +++ F   + E   D C+ DFV V + +    +L G++
Sbjct: 691  FPDLYPPDKNCVWHISAPKGHTLTVNFTHMDLEWRGDECELDFVRVTNVVGNKERLQGQY 750

Query: 666  CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSY 725
            CG   P  ITS  N +R+EF+SD+T+ K GF   + +D DEC+  NGGC+  C NT GS+
Sbjct: 751  CGFMAPPSITSLSNELRIEFRSDDTLQKTGFSMDYVADVDECASSNGGCKHICENTVGSF 810

Query: 726  ECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRV 785
             C CR GF+L D++  CKE GC ++VT T G I SP++P  YP++++C W  ++ PGH V
Sbjct: 811  HCSCREGFILADDEKSCKEGGCHYEVTDTKGVIQSPDYPSFYPARRDCEWHFTTAPGHVV 870

Query: 786  KLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDN 845
            +L F +  +E    C YDH+E FDG + +AP +G++CGS+KP P++++ + + L F SD 
Sbjct: 871  RLIFTDFQVEPHRTCRYDHVEAFDGANIQAPQIGKYCGSEKPAPIISSENTLTLTFLSDT 930

Query: 846  SVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELV 905
            SVQRKGF+A H T C     A    K + SH  +G   Y    +C W I A EG  VEL 
Sbjct: 931  SVQRKGFRARHDTVCQSSPTATSAPKKILSHVLYGSKPYDNRQNCSWNIQAPEGQHVELR 990

Query: 906  FQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTIT 965
            F  FE+E+++ C YDY+ ++DG       LG++CG+  P  + S+  S+LV+F SDDTI 
Sbjct: 991  FTAFEIEQQSRCLYDYVAVYDGPTENDLVLGKFCGNQVPSPIVSSTRSLLVRFRSDDTIK 1050

Query: 966  KKGFHLRYTSTKFQDT 981
              GF   Y      DT
Sbjct: 1051 SGGFSATYRIADDTDT 1066



 Score = 34.0 bits (76), Expect = 8.2
 Identities = 18/42 (42%), Positives = 25/42 (58%), Gaps = 7/42 (16%)

Query: 43 YKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSI 84
          Y +PCKAA +L DIAL E +  +F+       RR  A K++I
Sbjct: 51 YMNPCKAAGYLDDIALTENEYESFE-------RRWLALKNNI 85



>sp|P25723|TLD_DROME DORSAL-VENTRAL PATTERNING TOLLOID PROTEIN PRECURSOR
 pir||A39288 dorsal-ventral patterning protein tolloid (EC 3.4.24.-) - fruit fly
            (Drosophila melanogaster)
 gb|AAA28491.1| (M76976) dorsal-ventral patterning protein [Drosophila melanogaster]
 gb|AAC46482.1| (U04239) tolloid protein [Drosophila melanogaster]
 gb|AAF56329.1| (AE003749) tld gene product [Drosophila melanogaster]
          Length = 1057

 Score =  801 bits (2047), Expect = 0.0
 Identities = 385/884 (43%), Positives = 554/884 (62%), Gaps = 40/884 (4%)

Query: 127  ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDE--DSYIVFTYRPCG 184
            ER W  GVIP+ I   F+G+ +A+F+QAMRHWE  TC+ F+ER      +YI FT + CG
Sbjct: 133  ERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCG 192

Query: 185  CCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPG 244
            CCS++G+ G G Q ISIG+NC+KFGI++HELGH +GF HEH R DRD+H+ I + NI  G
Sbjct: 193  CCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRG 252

Query: 245  QEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTR 304
            QEYNF  + P+EV+     YD +SIMHYA+N+FS+  +LDTI P     G    +GQR R
Sbjct: 253  QEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKR 312

Query: 305  LSKGDIAQARKLYKCPACGETLQDSTGNFSSPEY---PNGYSAHM--------------- 346
            LS+GDI QA  LYKC +CG T Q ++G+  SP +    NG  +                 
Sbjct: 313  LSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESE 372

Query: 347  ------HCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSK 400
                  +C WRI+ T GEK+IL+   L L  S  C  DY+E+RDG+W K+PL  R CG+ 
Sbjct: 373  FDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNV 432

Query: 401  LPEPIVSTDSRLWVEFRSSSNWVG-KGFFAVYEAICGGDVK--KDYGHIQSPNYPDDYRP 457
              E I +  SR+ + + + +   G +GF A +E +CGGD+K  KD   I SPNYP DY P
Sbjct: 433  SGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQS-IDSPNYPMDYMP 491

Query: 458  SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
             K C+WRI   +   V L FQSFE+E+HD CAYD++E+RDG+   S LIGR+CG + P +
Sbjct: 492  DKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPN 551

Query: 518  IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577
            IK+ S++++++FVSD S+ K GF+     +VDEC   + G C+  C+NTLGSY+C C  G
Sbjct: 552  IKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHG-CQHLCINTLGSYQCGCRAG 610

Query: 578  YELAPDKRRCEAACGGFL--TKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDF 635
            YEL  + + CE ACGG +  TK NGS+ SP +P  YP +K C+W++VAP  + + L F  
Sbjct: 611  YELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSH 670

Query: 636  FETEGNDV----CKYDFVEVRSGLTADSKLH--GKFCGSEKPEVITSQYNNMRVEFKSDN 689
            F+ EG       C YD++ + S +  D++L   G +CG E P V+ S+ + +R+EF SD 
Sbjct: 671  FDLEGTRFHYTKCNYDYLIIYSKMR-DNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDR 729

Query: 690  TVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDH 749
            TV + GF A F  D DECS +NGGCQ  C NTFGSY+C CR+G+ L +N H+C E  C  
Sbjct: 730  TVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKF 789

Query: 750  KVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFD 809
            ++T++ G + SPN+P+ YP    C W   +  GHR++LTF + ++ES  EC YD++ ++D
Sbjct: 790  EITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYD 849

Query: 810  GRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVK 869
            GR   +  LG +CG ++P  V+A+ + MF+   +D  +QRKGF+A+  +ECGG +RA   
Sbjct: 850  GRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRATNH 909

Query: 870  TKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYD 929
            ++  YSH ++G   Y   + C+W I A+    V++ F  FE+E    C YDY+E+ +   
Sbjct: 910  SQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEEGY 969

Query: 930  STAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
            S     GR+CG   P  + S  D++L++F +D++ + +GF + +
Sbjct: 970  SMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISF 1013



 Score =  309 bits (783), Expect = 1e-82
 Identities = 197/614 (32%), Positives = 290/614 (47%), Gaps = 114/614 (18%)

Query: 433 AICGGDVKKDYGHIQSPNY------------------PDDYRPSKV------CIWRIQVS 468
           A CG   +++ GHI SP++                   D    S+       C WRI  +
Sbjct: 328 ASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITAT 387

Query: 469 EGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLK 528
            G  V L  Q   +   D C  DYLE+RDG+   S L+ R CG    + I + +SR+ L 
Sbjct: 388 NGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLN 447

Query: 529 FVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588
           +V                        NR        N    Y+     G+     K R E
Sbjct: 448 YV------------------------NR--------NAAKGYR-----GF-----KARFE 465

Query: 589 AACGGFL--TKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKY 646
             CGG L  TK + SI SP +P +Y P+K C+W++ AP  ++++L+F  FE E +D C Y
Sbjct: 466 VVCGGDLKLTK-DQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAY 524

Query: 647 DFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDE 706
           DFVE+R G  +DS+L G+FCG + P  I ++ N M + F SD++V K GF A    D DE
Sbjct: 525 DFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDE 584

Query: 707 CSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEA-GCDHKVTSTSGTITSPNWPD 765
           C   + GCQ  C+NT GSY+C CR+G+ L  N   C++A G     T ++G++ SP++PD
Sbjct: 585 CKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPD 644

Query: 766 KYPSKKECTWAISSTPGHRVKLTFMEMDIESQ----PECAYDHLEVFDG-RDAKAPVLGR 820
            YP+ K+C W + + P H V L F   D+E       +C YD+L ++   RD +   +G 
Sbjct: 645 VYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGI 704

Query: 821 FCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHAT---EC-----GGQVRA------ 866
           +CG + P  V +  S + L FYSD +VQR GF A       EC     G Q R       
Sbjct: 705 YCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGS 764

Query: 867 -DVKTKDLYSHAQFGDN------------------------NYPGGVDCEWVIVAEEGYG 901
                ++ Y+ A+ G N                        +YP  + C W      G+ 
Sbjct: 765 YQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHR 824

Query: 902 VELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSD 961
           ++L F  FEVE   +C YDY+ ++DG    +  LG YCG   P  V ++ + + +   +D
Sbjct: 825 IQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATD 884

Query: 962 DTITKKGFHLRYTS 975
             + +KGF   + S
Sbjct: 885 AGLQRKGFKATFVS 898



 Score =  191 bits (481), Expect = 3e-47
 Identities = 127/474 (26%), Positives = 198/474 (40%), Gaps = 113/474 (23%)

Query: 317  YKCPACGETLQD----------STGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS 366
            Y+  A G+T +D          S G+  SP YP+ Y     CVW +   P   + LNF+ 
Sbjct: 611  YELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSH 670

Query: 367  LDLYRSRL----CWYDYV----EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRS 418
             DL  +R     C YDY+    ++RD   +K    G +CG +LP  + S  S L +EF S
Sbjct: 671  FDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKI---GIYCGHELPPVVNSEQSILRLEFYS 727

Query: 419  SSNWVGKGFFAVY-------------------------------------------EAIC 435
                   GF A +                                           E  C
Sbjct: 728  DRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRC 787

Query: 436  GGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEV 495
              ++   YG +QSPNYP+DY  +  C W  Q   G  + LTF  FE+E H  C YDY+ +
Sbjct: 788  KFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAI 847

Query: 496  RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPN 555
             DG SE+S+ +G YCG  +P  + ++++ +++   +D  + + GF   F  E        
Sbjct: 848  YDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSE-------- 899

Query: 556  RGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK----EY 611
                                               CGG+L   N S T    P+     Y
Sbjct: 900  -----------------------------------CGGYLRATNHSQTFYSHPRYGSRPY 924

Query: 612  PPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKP 671
              N  C W++ A  +  + ++F  FE E ++ C YD++E+     + + +HG+FCG  KP
Sbjct: 925  KRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKP 984

Query: 672  EVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSY 725
             +I S  + + + F++D + S +GF   F +   +  +D+ G   D V  F  Y
Sbjct: 985  PIIISNSDTLLLRFQTDESNSLRGFAISFMA--VDPPEDSVGEDFDAVTPFPGY 1036



>sp|P98069|BMPH_STRPU BONE MORPHOGENETIC PROTEIN 1 HOMOLOG PRECURSOR (SUBMP)
 gb|AAA30081.1| (L23838) homolog of human bone morphogenetic protein 1; putative
           [Strongylocentrotus purpuratus]
          Length = 639

 Score =  701 bits (1789), Expect = 0.0
 Identities = 323/550 (58%), Positives = 404/550 (72%), Gaps = 15/550 (2%)

Query: 46  PCKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQ 105
           PCKA+ FLGDIAL E+D     ++      RH   +   +      T T     T  +  
Sbjct: 36  PCKASGFLGDIALTEDDYEREMIRA-----RHNREQYRRRILQERQTRT-----TGARHH 85

Query: 106 XXXXXXXXXXXXXXXXXXXXPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVT 165
                               PER W D VIP+ I GNFTGSQRA+F+QAMRHWE +TC+T
Sbjct: 86  IKKRTIEEAKVRHVRAVTARPERRWTDAVIPYEIDGNFTGSQRAMFKQAMRHWENYTCIT 145

Query: 166 FLER----TDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGF 221
           F+ER    ++ D++IVFTY+ CGCCS+VGR+G G QA+S+GKNCDKFG+VVHELGHVVGF
Sbjct: 146 FVERNPANSEHDNHIVFTYQACGCCSFVGRKGDGAQAVSVGKNCDKFGVVVHELGHVVGF 205

Query: 222 WHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGI 281
           WHEHTRPDR+  V IV +NI PGQEYNF  ++  EV+SLGETYDF SIMHYARNTFSRGI
Sbjct: 206 WHEHTRPDRNEFVGIVHQNIVPGQEYNFRVLDAAEVDSLGETYDFASIMHYARNTFSRGI 265

Query: 282 FLDTIVPKYEV-NGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPN 340
           +LDTI+P+ +  +G++P IGQR  LS+GDI QA  LYKCP+CG TL +STGNFSSPE+P 
Sbjct: 266 WLDTILPRKDPESGIRPEIGQRKHLSEGDIIQANLLYKCPSCGRTLLESTGNFSSPEWPG 325

Query: 341 GYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSK 400
            Y     CVWRISVTPGE I L FT  +L  S  CWY+Y+EVRDG WR +PL GRFCG+ 
Sbjct: 326 QYDGDQTCVWRISVTPGETISLQFTGFELVGSDGCWYNYLEVRDGHWRHSPLLGRFCGAS 385

Query: 401 LPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKV 460
           LP+PI+S+DSRLW+E +SS++   +GF A YEAICGG ++++ G +QSPNYPDDY PSK 
Sbjct: 386 LPDPILSSDSRLWIELKSSAHRYSRGFAANYEAICGGHIERESGTLQSPNYPDDYHPSKE 445

Query: 461 CIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKS 520
           C+W I +   + VGL+FQSFEIERH++C YDY+EVRDGH ++S LIGRYCGY  PDDIKS
Sbjct: 446 CVWLITMPANYTVGLSFQSFEIERHETCIYDYVEVRDGHEDTSPLIGRYCGYFIPDDIKS 505

Query: 521 TSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYEL 580
           T +++ + FVSDGS+NK GF+ +FFKE DEC++P++GGC   C+NT+GSY+C C PGYEL
Sbjct: 506 TGNKMMVTFVSDGSVNKGGFSADFFKEKDECAQPDQGGCMDVCVNTIGSYRCDCRPGYEL 565

Query: 581 APDKRRCEAA 590
           + D RRCE A
Sbjct: 566 SSDGRRCEVA 575



 Score =  236 bits (597), Expect = 7e-61
 Identities = 119/312 (38%), Positives = 160/312 (51%), Gaps = 44/312 (14%)

Query: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           CG  + +  G+  SP +P  Y   + C+WRI V+ G  + L F  FE+   D C Y+YLE
Sbjct: 307 CGRTLLESTGNFSSPEWPGQYDGDQTCVWRISVTPGETISLQFTGFELVGSDGCWYNYLE 366

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
           VRDGH   S L+GR+CG   PD I S+ SRLW++  S       GFA N+          
Sbjct: 367 VRDGHWRHSPLLGRFCGASLPDPILSSDSRLWIELKSSAHRYSRGFAANY---------- 416

Query: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPN 614
                                            EA CGG + + +G++ SP +P +Y P+
Sbjct: 417 ---------------------------------EAICGGHIERESGTLQSPNYPDDYHPS 443

Query: 615 KNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVI 674
           K C+W +  P  Y + L F  FE E ++ C YD+VEVR G    S L G++CG   P+ I
Sbjct: 444 KECVWLITMPANYTVGLSFQSFEIERHETCIYDYVEVRDGHEDTSPLIGRYCGYFIPDDI 503

Query: 675 TSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK-DNGGCQQDCVNTFGSYECQCRSGF 733
            S  N M V F SD +V+K GF A FF +KDEC++ D GGC   CVNT GSY C CR G+
Sbjct: 504 KSTGNKMMVTFVSDGSVNKGGFSADFFKEKDECAQPDQGGCMDVCVNTIGSYRCDCRPGY 563

Query: 734 VLHDNKHDCKEA 745
            L  +   C+ A
Sbjct: 564 ELSSDGRRCEVA 575



 Score =  175 bits (438), Expect = 3e-42
 Identities = 81/231 (35%), Positives = 129/231 (55%), Gaps = 4/231 (1%)

Query: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
           C   +  ++G  +SP WP +Y   + C W IS TPG  + L F   ++     C Y++LE
Sbjct: 307 CGRTLLESTGNFSSPEWPGQYDGDQTCVWRISVTPGETISLQFTGFELVGSDGCWYNYLE 366

Query: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRA 866
           V DG    +P+LGRFCG+  P+P+L++ SR+++   S      +GF A++   CGG +  
Sbjct: 367 VRDGHWRHSPLLGRFCGASLPDPILSSDSRLWIELKSSAHRYSRGFAANYEAICGGHIER 426

Query: 867 DVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFD 926
           +  T        + D+ +P   +C W+I     Y V L FQ+FE+E    C YDY+E+ D
Sbjct: 427 ESGT---LQSPNYPDDYHP-SKECVWLITMPANYTVGLSFQSFEIERHETCIYDYVEVRD 482

Query: 927 GYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTK 977
           G++ T+P +GRYCG   P+++ S G+ ++V F SD ++ K GF   +   K
Sbjct: 483 GHEDTSPLIGRYCGYFIPDDIKSTGNKMMVTFVSDGSVNKGGFSADFFKEK 533



 Score =  165 bits (414), Expect = 2e-39
 Identities = 88/270 (32%), Positives = 132/270 (48%), Gaps = 43/270 (15%)

Query: 590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFV 649
           +CG  L +  G+ +SP WP +Y  ++ C+W++       ISLQF  FE  G+D C Y+++
Sbjct: 306 SCGRTLLESTGNFSSPEWPGQYDGDQTCVWRISVTPGETISLQFTGFELVGSDGCWYNYL 365

Query: 650 EVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709
           EVR G    S L G+FCG+  P+ I S  + + +E KS      +GF A++         
Sbjct: 366 EVRDGHWRHSPLLGRFCGASLPDPILSSDSRLWIELKSSAHRYSRGFAANY--------- 416

Query: 710 DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPS 769
                                             EA C   +   SGT+ SPN+PD Y  
Sbjct: 417 ----------------------------------EAICGGHIERESGTLQSPNYPDDYHP 442

Query: 770 KKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829
            KEC W I+    + V L+F   +IE    C YD++EV DG +  +P++GR+CG   P+ 
Sbjct: 443 SKECVWLITMPANYTVGLSFQSFEIERHETCIYDYVEVRDGHEDTSPLIGRYCGYFIPDD 502

Query: 830 VLATGSRMFLRFYSDNSVQRKGFQASHATE 859
           + +TG++M + F SD SV + GF A    E
Sbjct: 503 IKSTGNKMMVTFVSDGSVNKGGFSADFFKE 532



>gb|AAC41710.1| (L35279) bone morphogenetic protein [Homo sapiens]
          Length = 284

 Score =  613 bits (1563), Expect = e-174
 Identities = 282/284 (99%), Positives = 283/284 (99%)

Query: 703 DKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPN 762
           DKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGC+HKVTSTSGTITSPN
Sbjct: 1   DKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCNHKVTSTSGTITSPN 60

Query: 763 WPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFC 822
           WPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFC
Sbjct: 61  WPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFC 120

Query: 823 GSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDN 882
           GSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDN
Sbjct: 121 GSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDN 180

Query: 883 NYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSG 942
           NYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAP LGRYCGSG
Sbjct: 181 NYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPSLGRYCGSG 240

Query: 943 PPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK 986
           PPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK
Sbjct: 241 PPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQDTLHSRK 284



 Score =  212 bits (534), Expect = 2e-53
 Identities = 112/311 (36%), Positives = 165/311 (53%), Gaps = 41/311 (13%)

Query: 549 DECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRC-EAACGGFLTKLNGSITSPGW 607
           DECS+ N GGC+Q C+NT GSY+C C  G+ L  +K  C EA C   +T  +G+ITSP W
Sbjct: 3   DECSKDN-GGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCNHKVTSTSGTITSPNW 61

Query: 608 PKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCG 667
           P +YP  K C W + +   +R+ L F   + E    C YD +EV  G  A + + G+FCG
Sbjct: 62  PDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCG 121

Query: 668 SEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYEC 727
           S+KPE + +  + M + F SDN+V +KGF+A   S   EC    GG  +  V T   Y  
Sbjct: 122 SKKPEPVLATGSRMFLRFYSDNSVQRKGFQA---SHATEC----GGQVRADVKTKDLYS- 173

Query: 728 QCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKL 787
                   H    D                       + YP   +C W I +  G+ V+L
Sbjct: 174 --------HAQFGD-----------------------NNYPGGVDCEWVIVAEEGYGVEL 202

Query: 788 TFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSV 847
            F   ++E + +C YD++E+FDG D+ AP LGR+CGS  PE V + G  + ++F+SD+++
Sbjct: 203 VFQTFEVEEETDCGYDYMELFDGYDSTAPSLGRYCGSGPPEEVYSAGDSVLVKFHSDDTI 262

Query: 848 QRKGFQASHAT 858
            +KGF   + +
Sbjct: 263 TKKGFHLRYTS 273



 Score =  182 bits (458), Expect = 1e-44
 Identities = 90/230 (39%), Positives = 133/230 (57%), Gaps = 10/230 (4%)

Query: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
           C   +  ++G  +SP +P+ Y +   C W IS TPG ++ L F  +D+     C YD++E
Sbjct: 45  CNHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 104

Query: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
           V DG   KAP+ GRFCGSK PEP+++T SR+++ F S ++   KGF A +   CGG V+ 
Sbjct: 105 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQVRA 164

Query: 442 D------YGHIQSPNYPDDYRPSKV-CIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
           D      Y H Q   + D+  P  V C W I   EG+ V L FQ+FE+E    C YDY+E
Sbjct: 165 DVKTKDLYSHAQ---FGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYME 221

Query: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
           + DG+  ++  +GRYCG   P+++ S    + +KF SD +I K GF + +
Sbjct: 222 LFDGYDSTAPSLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 271



 Score =  155 bits (388), Expect = 2e-36
 Identities = 87/273 (31%), Positives = 128/273 (46%), Gaps = 39/273 (14%)

Query: 432 EAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
           EA C   V    G I SPN+PD Y   K C W I  + G  V LTF   +IE    CAYD
Sbjct: 42  EAGCNHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYD 101

Query: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDEC 551
           +LEV DG    + ++GR+CG +KP+ + +T SR++L+F SD S+ + GF  +      EC
Sbjct: 102 HLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQAS---HATEC 158

Query: 552 SRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEY 611
               R   + + L +   +                                        Y
Sbjct: 159 GGQVRADVKTKDLYSHAQF------------------------------------GDNNY 182

Query: 612 PPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKP 671
           P   +C W +VA   Y + L F  FE E    C YD++E+  G  + +   G++CGS  P
Sbjct: 183 PGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPSLGRYCGSGPP 242

Query: 672 EVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDK 704
           E + S  +++ V+F SD+T++KKGF   + S K
Sbjct: 243 EEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTK 275



>pir||T30018 hypothetical protein F38E9.2 - Caenorhabditis elegans
 gb|AAA93348.1| (U46668) similar to developmentally important proteins like human
           BMP-1 and drosophila tolloid that contain C1R and C1S
           repeats found in human complement proteins
           [Caenorhabditis elegans]
          Length = 767

 Score =  506 bits (1290), Expect = e-142
 Identities = 286/785 (36%), Positives = 407/785 (51%), Gaps = 94/785 (11%)

Query: 233 HVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEV 292
           +V I  ++IQ GQ+YNF K +P+EV+SLGE YDF SIMHYAR+TFSRG F DTI+PK   
Sbjct: 2   YVDIFYKSIQTGQDYNFEKSKPEEVDSLGEPYDFSSIMHYARDTFSRGAFYDTILPKPN- 60

Query: 293 NGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMH---CV 349
           +G +  IGQR +LS+GDI Q +KLYKC  CG TL   +GN           A  H   C 
Sbjct: 61  SGFRLEIGQRVQLSEGDIRQTKKLYKCAECGGTLMQESGNL----------AIQHAGVCT 110

Query: 350 WRISVTPGEKIILNFTS---------------------------LDLYRSRLCWYDYVEV 382
           W I    G  I LN T                            L   ++ L W  ++  
Sbjct: 111 WHIISPQGHTIFLNITGGLKLIIMIIFLTDEKLEDLTEIFKPNILKKNQTYLHWKTFLIY 170

Query: 383 RDGFWRKAPLRGRFCGS-KLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKK 441
               +    +  R CG   L   I S+ +R+ ++ RSS+      F A Y AICGG +  
Sbjct: 171 YTNSFFHFEILDRICGGDSLFRTIASSGNRMLIQVRSSTPAASLPF-ATYYAICGGPIYA 229

Query: 442 DYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSE 501
           + G I SP YP+ Y P+  C W I V E   V + F  F +E+H  C YD L + +G S+
Sbjct: 230 NEGVIHSPKYPESYPPNSDCQWTIHVDENSQVAIEFVYFHLEQHKECIYDRLILTEGISK 289

Query: 502 SSTLIGR-----YCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNR 556
           +S   G+     +CG  +   I S ++++ L+F SD S+ K GF + F KE++EC+  ++
Sbjct: 290 NSKKDGKEMSETFCGLIEKKTIVSKTNQISLRFFSDNSVQKTGFELRFTKELNECAT-DK 348

Query: 557 GGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKN 616
             C   C+NT+G +KC+C  GY L+ +   C++ CGG+L   NGSI+SP +P+ YP +K 
Sbjct: 349 NICHHYCVNTVGGFKCACRVGYSLSSNGFSCDSTCGGYLKASNGSISSPNFPEMYPNSKT 408

Query: 617 CIWQLVAPTQYRISLQFDFFETEGNDV-CKYDFVEVRSGLTADSKLHGKFCGSEKPEVI- 674
           CIW++ AP  Y I L F  F  EG    C YD+V++      DS+   K CG     ++ 
Sbjct: 409 CIWEIEAPDGYHIFLNFTKFNVEGMKTECAYDYVKI-----GDSE---KLCGEYHEALLF 460

Query: 675 TSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFV 734
           T+  N +R+EF SD++V + GF A+F +D DEC  DN GC+  C N  GSY C C  G++
Sbjct: 461 TTPRNRVRIEFSSDSSVERDGFFANFIADFDECQNDNAGCEHTCQNRLGSYVCTCNPGYI 520

Query: 735 LHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDI 794
           L ++KH+CKE  C  +V + +G I SPN+P+ YP  + C+W   +TPGHR+ LTF    +
Sbjct: 521 LAEDKHNCKEGSCFFEVNAPAGDINSPNYPNDYPKGQNCSWHFVTTPGHRLMLTFSSFQV 580

Query: 795 ESQPECAYDHLEVFDGRDAKAPVLG---RFCGSK--KPEPVLATGSRMFLRFYSDNSVQR 849
           E   +C YD + V+DG D  A + G     C +    P       +     F        
Sbjct: 581 EEHAQCKYDAVSVYDGGDGSAQLAGWSFSACSAAWLHPHSFYRPPTSSISLFRRTRRSLD 640

Query: 850 KGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTF 909
           + F+     +C   VRA                                G GV + F TF
Sbjct: 641 EAFRLITLLDCSWIVRA-----------------------------KSPGRGVRIQFSTF 671

Query: 910 EVEEETDCGYDYMELFDGYDSTAPRL-GRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKG 968
            +E E  C YDY+E++DG ++T  RL GR+CG   PE + S G  +L+  H+D+   +KG
Sbjct: 672 NIESEEGCQYDYIEIYDGPEATLERLVGRFCGDTSPEVITSTGPELLLIMHTDNAEEEKG 731

Query: 969 FHLRY 973
           F   Y
Sbjct: 732 FVAEY 736



 Score = 74.5 bits (180), Expect = 5e-12
 Identities = 59/235 (25%), Positives = 97/235 (41%), Gaps = 38/235 (16%)

Query: 773 CTWAISSTPGHRVKLTF------MEMDIESQPECAYDHLEVFDGRDAKA----------- 815
           CTW I S  GH + L        + M I    E   D  E+F     K            
Sbjct: 109 CTWHIISPQGHTIFLNITGGLKLIIMIIFLTDEKLEDLTEIFKPNILKKNQTYLHWKTFL 168

Query: 816 ----------PVLGRFCGSKKP-EPVLATGSRMFLRFYSDNSVQRKGFQASHATECGGQV 864
                      +L R CG       + ++G+RM ++  S        F   +A  CGG +
Sbjct: 169 IYYTNSFFHFEILDRICGGDSLFRTIASSGNRMLIQVRSSTPAASLPFATYYAI-CGGPI 227

Query: 865 RADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMEL 924
            A+    +   H+     +YP   DC+W I  +E   V + F  F +E+  +C YD + L
Sbjct: 228 YAN----EGVIHSPKYPESYPPNSDCQWTIHVDENSQVAIEFVYFHLEQHKECIYDRLIL 283

Query: 925 FDGYDSTAPRLGR-----YCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYT 974
            +G    + + G+     +CG    + + S  + + ++F SD+++ K GF LR+T
Sbjct: 284 TEGISKNSKKDGKEMSETFCGLIEKKTIVSKTNQISLRFFSDNSVQKTGFELRFT 338



>dbj|BAA75639.1| (AB012139) procollagen C-proteinase 3 [Rattus norvegicus]
          Length = 241

 Score =  471 bits (1200), Expect = e-131
 Identities = 220/230 (95%), Positives = 220/230 (95%), Gaps = 8/230 (3%)

Query: 485 HDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
           HDSCAYDYLEVRDGHSESS LIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF
Sbjct: 1   HDSCAYDYLEVRDGHSESSNLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 60

Query: 545 FKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITS 604
           FKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITS
Sbjct: 61  FKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITS 120

Query: 605 PGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGK 664
           PGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGK
Sbjct: 121 PGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGK 180

Query: 665 FCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGC 714
           FCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS         GGC
Sbjct: 181 FCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS--------GGGC 222



Lambda     K      H
   0.319    0.137    0.438 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 396504119
Number of Sequences: 582290
Number of extensions: 18261201
Number of successful extensions: 45298
Number of sequences better than 10.0: 829
Number of HSP's better than 10.0 without gapping: 629
Number of HSP's successfully gapped in prelim test: 200
Number of HSP's that attempted gapping in prelim test: 33955
Number of HSP's gapped (non-prelim): 8344
length of query: 986
length of database: 183,345,511
effective HSP length: 54
effective length of query: 932
effective length of database: 151,901,851
effective search space: 141572525132
effective search space used: 141572525132
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 76 (34.0 bits)









  

 
    
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