NT-ARC105, NT-GAL11, NT-CBPplant and KIX
 A family of homologous domains
1fyv
 

Supplementary material for the publication:
"The family of homologous domains NT-ARC105, NT-GAL11, NT-plantCBP and KIX for linking transcriptional activators and co-activators"
by Maria Novatchkova and Frank Eisenhaber


  • NT-ARC105, NT-GAL11, NT-plantCBP and KIX-domain proteins are summarized in the table below. Follow the links for the
    NCBI sequence retrieval
    full length BLAST
    NT-ARC105/NT-GAL11/NT-plantCBP/KIX domain BLAST (-- domain not present)


    Q21955
    /Ce ARC105
    NP_608528
    /Dm ARC105

    AAH45472
    /Dr ARC105

    AAN62354
    /CTV.22

    NP_178842
    /At2g10440
    no EST
    AAH46263
    /Xl ARC105
    NP_173031

    PSI: 1 2 3 4 5 6 7 8 9
    NP_173029
    /At1g15770
    -- no EST
    Q924H2/
    Mm ARC105

    BAC56002

    CTV.20
    CAE03805
    viral seq
    Ec NP_586100

    Hs ARC105

    PSI: 1 2 3 4 5 6 7 8
    NP_509376

    CBP_HUMAN

    NP_173030

    PSI: 1 2 3 4 5 6 7 8 9
    Ca Gal11

    PSI: 1 2 3 4 5 6 7 8 9
    NP_595390
    /Sp Gal11

    NP_499201

    NP_493339

    P300_HUMAN

    CBP_MOUSE

    Sc Gal11

    Kl Gal11

    NP_497145

    NP_497144

    CBP1_CAEE

    AAB31182

    Dm nejire

    Aplysia_CBP

    NP_187904
    /At3g12980

    NP_565197
    /At1g79000

    NP_173115
    /At1g16710

    NP_564004


  • Analysis
    1. Sequence searches defining the NT-ARC105 domain, rounds 1 2 3 4 5 6 7 8
    2. Domain and Fold recognition methods support a NT-ARC105/KIX similarity Link to the data ->

      CDDsearch, PFAM, Superfamily, Sam-T02, FFAS03, Fischers Fold recognition and FUGUE2 were used to analyse the NT-ARC105 domain in ARC105 proteins in C elegans, D melanogaster, D rerio, X laevis, M musculus, H sapiens.


  • Analysis
    1. Sequence searches defining the NT-GAL11 domain, rounds 1 2 3 4 5 6 7 8 9
    2. Domain and Fold recognition methods support a NT-GAL11/KIX similarity Link to the data ->

      CDDsearch, PFAM, Superfamily, Sam-T02, FFAS03, Fischers Fold recognition and FUGUE2 were used to analyse the NT-GAL11 domain in fungal and plantal GAL11 proteins.


  • Analysis
    1. Sequence searches defining the NT-plantCBP domain, rounds 1 2
    2. Domain and Fold recognition methods support a NT-plantCBP/KIX similarity Link to the data ->

      CDDsearch, PFAM, Superfamily, Sam-T02, FFAS03, Fischers Fold recognition and FUGUE2 were used to analyse the NT-plantCBP domain in plant CBP proteins.


  • PSSM of plantal NP_173030 likely orthologs. Applying that PSSM to psi-blast we obtain ARC105/PCAP proteins as subsignificant hits (Xl-0.045, Ce-1.6...).