Query Ver_Hs_NP_057225.1_DNCLI1 Command /cluster/toolkit/production/bioprogs/hhpred/hhsearch -cpu 4 -v 1 -i /cluster/toolkit/production/tmp/production/96182/c_NP_057225.hhm -d /cluster/toolkit/production/databases/hhpred/new_dbs/pfam_18Apr07/db//pfam.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/smart_18Apr07/db/smart.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/KOG_18Apr07/db/KOG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/COG_18Apr07/db/COG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/cd_18Apr07/db/cd.hhm -o /cluster/toolkit/production/tmp/production/96182/c_NP_057225.hhr -p 20 -P 20 -Z 100 -B 100 -seq 1 -aliw 80 -local -ssm 2 -norealign -sc 1 No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 pfam05783 DLIC Dynein light in 100.0 0 0 1342.8 40.5 474 21-517 1-475 (475) 2 KOG3905 Dynein light intermedi 100.0 0 0 1298.3 35.6 473 14-522 1-473 (473) 3 KOG3929 Uncharacterized conser 99.9 1.7E-26 7.9E-31 191.5 10.9 246 39-335 29-282 (363) 4 cd04128 Spg1 Spg1p. Spg1p (se 99.3 2.7E-11 1.3E-15 92.3 11.3 177 70-321 3-182 (182) 5 cd00154 Rab Rab family. Rab G 99.1 2.8E-10 1.3E-14 85.7 8.4 152 70-300 3-157 (159) 6 cd01868 Rab11_like Rab11-like. 99.1 3.2E-10 1.5E-14 85.3 8.6 159 70-305 6-165 (165) 7 cd00877 Ran Ran (Ras-related n 99.1 1E-09 4.9E-14 82.0 10.6 157 70-308 3-162 (166) 8 cd04122 Rab14 Rab14 subfamily. 99.1 5.5E-10 2.6E-14 83.8 9.0 159 70-305 5-164 (166) 9 cd01866 Rab2 Rab2 subfamily. 99.1 2E-09 9.5E-14 80.1 11.3 157 70-305 7-166 (168) 10 pfam00071 Ras Ras family. Incl 99.0 8.8E-10 4.2E-14 82.4 9.1 159 70-305 2-161 (162) 11 cd04119 RJL RJL (RabJ-Like) su 99.0 2.1E-09 9.9E-14 80.0 10.4 162 70-306 3-168 (168) 12 cd04106 Rab23_lke Rab23-like s 99.0 7.2E-10 3.4E-14 83.0 7.9 156 70-303 3-161 (162) 13 cd00876 Ras Ras family. The R 99.0 7.3E-10 3.5E-14 83.0 7.8 159 70-304 2-160 (160) 14 cd04101 RabL4 RabL4 (Rab-like4 99.0 1.2E-09 5.6E-14 81.6 8.4 157 70-305 3-164 (164) 15 cd04108 Rab36_Rab34 Rab34/Rab3 99.0 1.3E-09 6.3E-14 81.3 8.5 163 70-307 3-167 (170) 16 cd04109 Rab28 Rab28 subfamily. 99.0 2E-09 9.3E-14 80.2 9.3 170 70-314 3-175 (215) 17 cd01863 Rab18 Rab18 subfamily. 99.0 2.1E-09 1E-13 80.0 9.4 156 70-304 3-161 (161) 18 cd04116 Rab9 Rab9 subfamily. 99.0 2.8E-09 1.4E-13 79.1 9.7 161 70-304 8-170 (170) 19 cd04123 Rab21 Rab21 subfamily. 99.0 2.2E-09 1E-13 79.9 9.1 156 70-304 3-161 (162) 20 cd01865 Rab3 Rab3 subfamily. 99.0 4.2E-09 2E-13 78.0 10.6 156 70-304 4-162 (165) 21 cd04112 Rab26 Rab26 subfamily. 99.0 2E-09 9.6E-14 80.1 8.7 156 70-304 3-162 (191) 22 cd04115 Rab33B_Rab33A Rab33B/R 99.0 2.3E-09 1.1E-13 79.8 8.5 157 70-304 5-168 (170) 23 cd04113 Rab4 Rab4 subfamily. 98.9 2.3E-09 1.1E-13 79.7 8.1 158 70-304 3-161 (161) 24 cd04110 Rab35 Rab35 subfamily. 98.9 4.9E-09 2.3E-13 77.6 9.1 156 70-305 9-167 (199) 25 cd04139 RalA_RalB RalA/RalB su 98.9 4.6E-09 2.2E-13 77.7 8.9 157 70-305 3-162 (164) 26 cd01861 Rab6 Rab6 subfamily. 98.9 3.3E-09 1.6E-13 78.7 8.0 156 70-304 3-161 (161) 27 cd04120 Rab12 Rab12 subfamily. 98.9 5.1E-09 2.5E-13 77.4 8.8 157 70-305 3-163 (202) 28 cd04127 Rab27A Rab27a subfamil 98.9 5.3E-09 2.5E-13 77.4 8.6 160 70-305 7-177 (180) 29 cd04114 Rab30 Rab30 subfamily. 98.9 6E-09 2.8E-13 77.0 8.7 158 70-304 10-168 (169) 30 cd01864 Rab19 Rab19 subfamily. 98.9 4.7E-09 2.2E-13 77.7 8.2 156 70-304 6-165 (165) 31 cd04140 ARHI_like ARHI subfami 98.9 9.8E-09 4.7E-13 75.6 9.8 159 70-304 4-164 (165) 32 cd00157 Rho Rho (Ras homology) 98.9 2.8E-09 1.3E-13 79.2 6.9 167 69-301 2-169 (171) 33 cd04125 RabA_like RabA-like su 98.9 7.2E-09 3.4E-13 76.5 9.0 157 70-305 3-162 (188) 34 cd04124 RabL2 RabL2 subfamily. 98.9 1.2E-08 5.6E-13 75.1 10.0 154 70-304 3-157 (161) 35 cd01860 Rab5_related Rab5-rela 98.9 3.9E-09 1.8E-13 78.3 7.4 158 70-304 4-162 (163) 36 cd01867 Rab8_Rab10_Rab13_like 98.9 7.5E-09 3.6E-13 76.4 8.8 157 70-305 6-165 (167) 37 cd01862 Rab7 Rab7 subfamily. 98.9 7.4E-09 3.5E-13 76.4 8.4 159 70-305 3-167 (172) 38 cd04132 Rho4_like Rho4-like su 98.9 2.1E-08 1E-12 73.5 10.4 165 68-305 1-167 (187) 39 cd04107 Rab32_Rab38 Rab38/Rab3 98.8 1.7E-08 8.1E-13 74.1 9.5 162 70-305 3-168 (201) 40 cd04117 Rab15 Rab15 subfamily. 98.8 2.3E-08 1.1E-12 73.2 10.0 156 70-304 3-161 (161) 41 smart00174 RHO Rho (Ras homolo 98.8 9.2E-09 4.4E-13 75.8 7.9 172 70-307 1-174 (174) 42 smart00175 RAB Rab subfamily o 98.8 1.5E-08 7.2E-13 74.4 8.9 159 70-305 3-162 (164) 43 cd04136 Rap_like Rap-like subf 98.8 9.2E-09 4.4E-13 75.8 7.4 159 70-304 4-162 (163) 44 cd01869 Rab1_Ypt1 Rab1/Ypt1 su 98.8 2.6E-08 1.2E-12 72.9 9.3 157 70-305 5-164 (166) 45 cd04137 RheB Rheb (Ras Homolog 98.8 5.9E-08 2.8E-12 70.6 10.8 177 68-322 2-180 (180) 46 smart00173 RAS Ras subfamily o 98.7 3.1E-08 1.5E-12 72.3 8.4 159 70-305 5-164 (166) 47 cd04121 Rab40 Rab40 subfamily. 98.7 4.3E-08 2E-12 71.4 9.1 154 70-303 9-169 (235) 48 cd04138 H_N_K_Ras_like H-Ras/N 98.7 3.2E-08 1.5E-12 72.3 8.4 158 70-304 4-161 (162) 49 cd04175 Rap1 Rap1 subgroup. T 98.7 7.6E-08 3.6E-12 69.8 9.9 157 70-305 4-163 (164) 50 cd04159 Arl10_like Arl10-like 98.7 7.3E-08 3.5E-12 70.0 9.8 155 70-301 2-157 (159) 51 cd04111 Rab39 Rab39 subfamily. 98.7 6.3E-08 3E-12 70.3 9.4 158 70-305 5-166 (211) 52 cd04134 Rho3 Rho3 subfamily. 98.7 4.7E-08 2.2E-12 71.2 8.5 179 68-313 1-182 (189) 53 cd04141 Rit_Rin_Ric Rit/Rin/Ri 98.7 5.6E-08 2.7E-12 70.7 8.5 160 70-305 5-164 (172) 54 cd04118 Rab24 Rab24 subfamily. 98.7 5E-08 2.4E-12 71.0 8.3 162 70-305 3-166 (193) 55 cd04160 Arfrp1 Arfrp1 subfamil 98.7 1.1E-07 5.1E-12 68.8 9.9 158 69-303 1-167 (167) 56 cd04152 Arl4_Arl7 Arl4/Arl7 su 98.7 2.6E-07 1.2E-11 66.4 11.7 164 69-304 5-169 (183) 57 cd04133 Rop_like Rop subfamily 98.7 9.2E-08 4.4E-12 69.3 9.4 162 70-308 4-176 (176) 58 cd04146 RERG_RasL11_like RERG/ 98.7 9.2E-08 4.4E-12 69.3 8.7 157 70-304 2-163 (165) 59 cd01870 RhoA_like RhoA-like su 98.6 9E-08 4.3E-12 69.3 7.8 161 70-301 4-171 (175) 60 cd00878 Arf_Arl Arf (ADP-ribos 98.6 1.5E-07 7.3E-12 67.8 8.6 156 70-302 2-157 (158) 61 cd04135 Tc10 TC10 subfamily. 98.6 8E-08 3.8E-12 69.7 6.9 161 70-301 3-170 (174) 62 cd04156 ARLTS1 ARLTS1 subfamil 98.6 1.5E-07 7E-12 68.0 8.0 156 70-300 2-157 (160) 63 cd04143 Rhes_like Rhes_like su 98.6 1.7E-07 8E-12 67.6 8.1 163 70-301 3-167 (247) 64 cd04147 Ras_dva Ras-dva subfam 98.6 2.1E-07 9.8E-12 67.0 8.2 174 70-321 2-179 (198) 65 cd04129 Rho2 Rho2 subfamily. 98.6 3.4E-07 1.6E-11 65.6 9.1 176 70-312 4-180 (187) 66 cd04126 Rab20 Rab20 subfamily. 98.5 2.8E-07 1.3E-11 66.1 8.6 164 70-305 3-190 (220) 67 cd04176 Rap2 Rap2 subgroup. T 98.5 3E-07 1.4E-11 65.9 8.4 159 70-304 4-162 (163) 68 cd04151 Arl1 Arl1 subfamily. 98.5 5.1E-07 2.4E-11 64.4 9.5 155 70-301 2-156 (158) 69 cd04144 Ras2 Ras2 subfamily. 98.5 4.4E-07 2.1E-11 64.9 9.0 158 70-304 2-162 (190) 70 cd04131 Rnd Rnd subfamily. Th 98.5 1.8E-07 8.4E-12 67.4 6.9 166 70-301 4-172 (178) 71 cd01875 RhoG RhoG subfamily. 98.5 3.4E-07 1.6E-11 65.6 8.0 173 70-308 6-180 (191) 72 cd01893 Miro1 Miro1 subfamily. 98.5 6.4E-07 3E-11 63.8 9.3 152 70-300 3-159 (166) 73 cd01874 Cdc42 Cdc42 subfamily. 98.5 3.8E-07 1.8E-11 65.2 7.9 164 70-301 4-171 (175) 74 smart00176 RAN Ran (Ras-relate 98.5 4.5E-07 2.2E-11 64.8 8.3 154 73-308 1-157 (200) 75 pfam00025 Arf ADP-ribosylation 98.5 4.6E-07 2.2E-11 64.7 8.3 159 70-304 18-176 (176) 76 cd04177 RSR1 RSR1 subgroup. R 98.5 2.5E-07 1.2E-11 66.4 7.0 160 70-305 4-164 (168) 77 KOG1673 Ras GTPases [General f 98.5 1.9E-07 9E-12 67.2 6.2 194 57-323 5-204 (205) 78 cd01895 EngA2 EngA2 subfamily. 98.5 2.6E-06 1.2E-10 59.8 11.9 155 67-300 2-170 (174) 79 cd04154 Arl2 Arl2 subfamily. 98.4 9.5E-07 4.5E-11 62.7 9.0 155 70-301 17-171 (173) 80 cd04172 Rnd3_RhoE_Rho8 Rnd3/Rh 98.4 6.4E-07 3.1E-11 63.8 7.7 171 70-307 8-182 (182) 81 cd00881 GTP_translation_factor 98.4 2.1E-06 1E-10 60.4 9.4 159 69-304 1-186 (189) 82 cd04145 M_R_Ras_like M-Ras/R-R 98.4 2E-06 9.5E-11 60.6 8.9 162 65-304 1-163 (164) 83 cd04155 Arl3 Arl3 subfamily. 98.3 1.5E-06 7E-11 61.4 7.8 156 69-301 16-171 (173) 84 cd04130 Wrch_1 Wrch-1 subfamil 98.3 1.5E-06 7.2E-11 61.4 7.6 164 70-301 3-170 (173) 85 cd01888 eIF2_gamma eIF2-gamma 98.3 4.9E-07 2.3E-11 64.5 5.1 162 69-304 2-198 (203) 86 cd04153 Arl5_Arl8 Arl5/Arl8 su 98.3 3.4E-06 1.6E-10 59.0 9.3 173 48-303 2-174 (174) 87 cd01883 EF1_alpha Eukaryotic e 98.3 5.7E-07 2.7E-11 64.1 5.1 140 69-279 1-174 (219) 88 cd04157 Arl6 Arl6 subfamily. 98.3 3.3E-06 1.6E-10 59.2 8.8 156 69-301 1-160 (162) 89 cd01898 Obg Obg subfamily. Th 98.3 8.7E-06 4.1E-10 56.4 10.8 158 70-304 3-170 (170) 90 cd04173 Rnd2_Rho7 Rnd2/Rho7 su 98.3 2.7E-06 1.3E-10 59.7 8.1 152 70-294 4-165 (222) 91 cd04158 ARD1 ARD1 subfamily. 98.2 4.5E-06 2.1E-10 58.3 8.7 159 70-304 2-160 (169) 92 cd01892 Miro2 Miro2 subfamily. 98.2 2.2E-06 1E-10 60.3 6.8 152 70-302 7-163 (169) 93 cd00882 Ras_like_GTPase Ras-li 98.2 2.5E-06 1.2E-10 59.9 7.1 156 72-302 1-157 (157) 94 smart00177 ARF ARF-like small 98.2 4.2E-06 2E-10 58.5 7.9 177 47-306 3-179 (181) 95 cd04174 Rnd1_Rho6 Rnd1/Rho6 su 98.2 6.7E-06 3.2E-10 57.2 8.3 185 70-325 16-212 (232) 96 cd01889 SelB_euk SelB subfamil 98.1 4.2E-06 2E-10 58.5 6.8 163 69-304 2-185 (192) 97 cd04149 Arf6 Arf6 subfamily. 98.1 9.7E-06 4.6E-10 56.1 8.3 156 69-301 11-166 (168) 98 cd04142 RRP22 RRP22 subfamily. 98.1 1.6E-05 7.6E-10 54.7 8.6 157 70-301 3-170 (198) 99 cd04166 CysN_ATPS CysN_ATPS su 98.1 9.7E-06 4.6E-10 56.1 7.2 150 69-293 1-182 (208) 100 cd04148 RGK RGK subfamily. Th 98.1 2.2E-05 1E-09 53.8 9.0 166 70-314 3-172 (221) No 1 >pfam05783 DLIC Dynein light intermediate chain (DLIC). This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo. Probab=100.00 E-value=0 Score=1342.79 Aligned_columns=474 Identities=73% Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCE Q ss_conf 45676532110468886666545336799999988641445425787658897369976789999974201468886521 Q Ver_Hs_NP_0572 21 YTGGPLGNEIASGNGGAAAGDDEDGQNLWSCILSEVSTRSRSKLPAGKNVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLE 100 (523) Q Consensus 21 ~~~~~~~~~~~~g~~~~~~~~~~~~~nlWssiL~~v~t~~~~klp~~KnILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLe 100 (523) +.+|+..|+++++-.+...+++++|||||||||++|+|++|+|||+||||||||++++|||||+++||++++++||+||| T Consensus 1 ~~~~~~~n~~~~~~~~~~~~~~~~k~nLWsSIL~~V~t~~r~Klp~~KniLVLG~~~~GKttLl~~Lqg~~~~kkg~aL~ 80 (475) T pfam05783 1 LESGDTANALASVFTGKLYSSTEEGQNLWSEILSEVSTRTRSKLPSGKNVLVLGDNGSGKTSLISRLQGSERTKKGRGLE 80 (475) T ss_pred CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCC T ss_conf 98762012333320267777410122478988865302533347776647885089975578999750577667863101 Q ss_pred EEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH Q ss_conf 45640450000432524636865862432455567870026664556554010136899999999999999997327898 Q Ver_Hs_NP_0572 101 YLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPP 180 (523) Q Consensus 101 Y~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ 180 (523) |+|+||+|+||||++|||||||||++||++||||||+++||+|||||||||||+||+||+||++|++|||+|+++|++++ T Consensus 81 Y~YldV~DeD~Dd~~R~~vwiLd~~~~~~~LLK~aL~~~si~~TlViI~lDms~PW~~i~qL~~Wi~VLrehi~~L~i~~ 160 (475) T pfam05783 81 YLYLHVHDEDRDDLTRCNVWILDGDLYHKGLLKFALPATSLAETLVILTASMSNPWTLLESLQKWASVLREHIDKLKIPP 160 (475) T ss_pred EEEECCCCCCHHHHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH T ss_conf 34632322030322154247608751522232125772314220120012120134899999999999999997138998 Q ss_pred HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCC Q ss_conf 89999999999999985045556666553445676667765344788876230058832799850741255554205774 Q Ver_Hs_NP_0572 181 EEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYR 260 (523) Q Consensus 181 ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~ 260 (523) |++++|++++|++||+|+|||++.+++++++++.....++++|.+|||||+||+||||||||||||||+|++|||||+|+ T Consensus 161 ee~~el~e~l~~~wqeY~epg~~~d~s~~r~t~~~~~~~~~~v~lPLgeg~Lt~NLGiPiiVVctKsD~ie~LEKe~~yk 240 (475) T pfam05783 161 EEMKAGRQKLEKDWQEYVEPGEDLDGSPQRRTSVVGSFDEEHVLLPLGQDTLTHNLGLPVLVVCTKCDAMSVLEKEHDYR 240 (475) T ss_pred HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEEEEECCCHHHHHHCCCCCC T ss_conf 89999999999999986055346787763245665653444565778876341278826999861762133332015664 Q ss_pred HHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCC Q ss_conf 78999999999999997187688832663678999999999876065556556411364025268888378888765276 Q Ver_Hs_NP_0572 261 DEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKIGILHENF 340 (523) Q Consensus 261 dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLygfpf~~~a~ViDrD~IfIPaGWDs~~KI~IL~Enf 340 (523) ||||||||||||+|||+|||||||||+|+++||+|||+||+||||||||+++|+|+|||+||||||||||+||+|||||| T Consensus 241 eE~fDfIqq~LR~~cLqYGAsLiYTS~ke~kNldlLykYl~HrlYgfpf~~~a~VvekDaIfIPsGWDn~kKI~Il~Enf 320 (475) T pfam05783 241 DEHFDFIQSHLRKFCLQYGAALIYTSVKETKNIDLLYKYIVHRSYGFPFTTPALVVEKDAVFIPAGWDNEKKIDILHENF 320 (475) T ss_pred HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEHHEEEECCCCCCHHHHHHHHCCC T ss_conf 36799999999999987097589854776423899999999886076545622001000034058888145567543365 Q ss_pred CCCCCCCCCCCCCCCCCCCHHHHHCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 11378753023678886512020021112407889999999986268778888766677887777768888877777755 Q Ver_Hs_NP_0572 341 QTLKAEDNFEDIITKPPVRKFVHEKEIMAEDDQVFLMKLQSLLAKQPPTAAGRPVDASPRVPGGSPRTPNRSVSSNVASV 420 (523) Q Consensus 341 ~~~~~~d~y~~ii~kPp~rk~~~~~ei~aedeQ~FL~klq~~l~~~p~t~a~~p~~~~~~~~~~s~~~~~~~~~~~~~~~ 420 (523) ++|+++|+|||||+|||+||.+|++||+|||||+||||||++|++||++++++|.+++ |.|+||+.+|+ +..+++. T Consensus 321 ~~~k~~~~~ed~i~kp~~rk~~~~~ei~aeddQ~Fl~k~q~~l~~~~~~~~~~~~~~~---~~~~p~~~~~~-~~~~~~~ 396 (475) T pfam05783 321 PTVKAEDAYEDIITKPPVRKVVHEKEIEAEDDQAFLMKLQSILAKQPTTAAPRPLRSQ---GVGSPRTMPRT-PGTVGQS 396 (475) T ss_pred CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC---CCCCCCCCCCC-CCCCCCC T ss_conf 4357876422344788402333333200012789999999997167877777755677---78887457745-5423666 Q ss_pred CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH-HHHHHH Q ss_conf 6555665556888888851100578888888742688887666666666666677766666544257743134-589999 Q Ver_Hs_NP_0572 421 SPIPAGSKKIDPNMKAGATSEGVLANFFNSLLSKKTGSPGGPGVSGGSPAGGAGGGSSGLPPSTKKSGQKPVL-DVHAEL 499 (523) Q Consensus 421 ~p~~~~~~k~d~~~~~~~~~egvLanFFnsLl~Kkt~sp~~~~~s~~~~~~~~~~~~~~~~~~~~~~~~~~~~-d~~~el 499 (523) +| +||+|||+++|+++||||||||||||||||||||.|+.. +++++++||++++ |||||| T Consensus 397 ~p----~kk~dp~~~~~~~~egvlanffnsll~kk~~sp~~~~~~---------------~~~~~~~~~~~~~~d~~~el 457 (475) T pfam05783 397 SP----TKKIDPNLKATAGSEGVLANFFNSLLSKKTGSPGKPGPG---------------GSSPSTVGQKMVLSDVQAEL 457 (475) T ss_pred CC----CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC---------------CCCCCCCCCHHHHHHHHHHH T ss_conf 77----646677757886431157777776630357888888888---------------87764665312378999999 Q ss_pred HHHHCCCCCCCCCCCCCC Q ss_conf 986337653356778876 Q Ver_Hs_NP_0572 500 DRITRKPVTVSPTTPTSP 517 (523) Q Consensus 500 dr~~~~~~~~~~~~~~~~ 517 (523) |||+|+|+++.|++++.+ T Consensus 458 dr~~r~~~~~~~~~~~~~ 475 (475) T pfam05783 458 DRLTRSPQSPKPMSPTES 475 (475) T ss_pred HHHHCCCCCCCCCCCCCC T ss_conf 987437787778886789 No 2 >KOG3905 Dynein light intermediate chain [Cell motility] Probab=100.00 E-value=0 Score=1298.29 Aligned_columns=473 Identities=78% Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCC Q ss_conf 86432234567653211046888666654533679999998864144542578765889736997678999997420146 Q Ver_Hs_NP_0572 14 PPGLSSTYTGGPLGNEIASGNGGAAAGDDEDGQNLWSCILSEVSTRSRSKLPAGKNVLLLGEDGAGKTSLIRKIQGIEEY 93 (523) Q Consensus 14 ~~~~~~~~~~~~~~~~~~~g~~~~~~~~~~~~~nlWssiL~~v~t~~~~klp~~KnILvLG~~~sGKTtLl~~Lq~~e~~ 93 (523) ||++..++.|||+||++++ .+..++|++|||||||+||+||+|+.|+|||+||||||||++++|||+||++||++|++ T Consensus 1 ppg~~~~l~~g~~~nav~s--~~~~~~deeegqnlWs~iLsev~T~~~sklpsgk~VlvlGdn~sGKtsLi~klqg~e~~ 78 (473) T KOG3905 1 PPGTAQPLEFGPTGNAVAS--VGYSSTDEEEGQNLWSEILSEVSTRTRSKLPSGKNVLVLGDNGSGKTSLISKLQGSETV 78 (473) T ss_pred CCCCCCCCCCCCCHHHHHH--HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCC T ss_conf 9886653246874134544--32014535677899999986542012344778865799705887457898876302456 Q ss_pred CCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH Q ss_conf 88865214564045000043252463686586243245556787002666455655401013689999999999999999 Q Ver_Hs_NP_0572 94 KKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHV 173 (523) Q Consensus 94 kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi 173 (523) |||+||||+||+||||||||++||+||||||++||++||||||++.|+++||||+++||++||+||++|++|++|||+|| T Consensus 79 KkgsgLeY~yl~V~de~RDd~tr~~VWiLDGd~~h~~LLk~al~ats~aetlviltasms~Pw~~lesLqkWa~Vl~ehi 158 (473) T KOG3905 79 KKGSGLEYLYLHVHDEDRDDLTRCNVWILDGDLYHKGLLKFALPATSLAETLVILTASMSNPWTLLESLQKWASVLREHI 158 (473) T ss_pred CCCCCCEEEEEEECCCCHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHH T ss_conf 77653126788621310044654871487187555212432046556154589899865750358999999999999989 Q ss_pred HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHH Q ss_conf 73278988999999999999998504555666655344567666776534478887623005883279985074125555 Q Ver_Hs_NP_0572 174 DKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVL 253 (523) Q Consensus 174 ~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~L 253 (523) +++++++|+|++++++++++||+|+|||+|+|+|||||++....+.|+++++||++++||||||||++|||||||+|.+| T Consensus 159 dkl~i~~ee~ka~rqk~~k~wQeYvep~e~~pgsp~~r~t~~~~~~de~~llPL~~dtLt~NlGi~vlVV~TK~D~~s~l 238 (473) T KOG3905 159 DKLKIPPEEMKAGRQKLEKDWQEYVEPGEDQPGSPQRRTTVVGSSADEHVLLPLGQDTLTHNLGIPVLVVCTKCDAVSVL 238 (473) T ss_pred HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEEEECCCHHHHH T ss_conf 86258989999999998888897605124788886203433356553111122677620000687479998424303345 Q ss_pred HHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHH Q ss_conf 42057747899999999999999718768883266367899999999987606555655641136402526888837888 Q Ver_Hs_NP_0572 254 EKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKI 333 (523) Q Consensus 254 EKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLygfpf~~~a~ViDrD~IfIPaGWDs~~KI 333 (523) ||||+|+||||||||+|||+|||+|||+|||||+||+|||+||||||+||+|||||+++|+|||||+|||||||||++|| T Consensus 239 eke~eyrDehfdfiq~~lRkFCLr~GaaLiyTSvKE~KNidllyKYivhr~yG~~fttpAlVVEkdaVfIPAGWD~eKKI 318 (473) T KOG3905 239 EKEHEYRDEHFDFIQSHLRKFCLRYGAALIYTSVKETKNIDLLYKYIVHRSYGFPFTTPALVVEKDAVFIPAGWDNEKKI 318 (473) T ss_pred HHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHEEECCEEEECCCCCCCCHH T ss_conf 52010016789999999999998606302554111245568888888876415531350012320314630466863002 Q ss_pred HHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 87652761137875302367888651202002111240788999999998626877888876667788777776888887 Q Ver_Hs_NP_0572 334 GILHENFQTLKAEDNFEDIITKPPVRKFVHEKEIMAEDDQVFLMKLQSLLAKQPPTAAGRPVDASPRVPGGSPRTPNRSV 413 (523) Q Consensus 334 ~IL~Enf~~~~~~d~y~~ii~kPp~rk~~~~~ei~aedeQ~FL~klq~~l~~~p~t~a~~p~~~~~~~~~~s~~~~~~~~ 413 (523) .||||||++++++|+|+|||.|||+||.+|++||+|||||+||||||++|++||+|++++|.++++|.|++|||||+|.+ T Consensus 319 ~Il~En~~~vkaed~y~d~itkpp~Rk~v~ekei~aEddQaFL~k~q~iLak~~~t~a~rp~~sq~~~~~ksprtpg~~g 398 (473) T KOG3905 319 DILHENFPTVKAEDNYEDIITKPPVRKVVHEKEIEAEDDQAFLMKLQSILAKQPTTAAPRPRTSQERGPDKSPRTPGRSG 398 (473) T ss_pred HHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC T ss_conf 21000356778776533243688401566666541013789999999986058888887865467888788876788876 Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH Q ss_conf 77777556555665556888888851100578888888742688887666666666666677766666544257743134 Q Ver_Hs_NP_0572 414 SSNVASVSPIPAGSKKIDPNMKAGATSEGVLANFFNSLLSKKTGSPGGPGVSGGSPAGGAGGGSSGLPPSTKKSGQKPVL 493 (523) Q Consensus 414 ~~~~~~~~p~~~~~~k~d~~~~~~~~~egvLanFFnsLl~Kkt~sp~~~~~s~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 493 (523) ++ || .||+|| ++||||||||||||||||||||+| |+++...++|++|||+|| T Consensus 399 ~s-----SP----~k~~~P------~segVlasffnsll~kktgspg~~-------------g~g~~~s~~~k~~q~~v~ 450 (473) T KOG3905 399 SS-----SP----LKKSDP------TSEGVLASFFNSLLSKKTGSPGGP-------------GAGGGSSSTKKSGQKPVL 450 (473) T ss_pred CC-----CC----CCCCCC------HHHHHHHHHHHHHHHHCCCCCCCC-------------CCCCCCCCCCCCCHHHHH T ss_conf 66-----78----888885------024678999998864126888888-------------887654211353102578 Q ss_pred HHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 58999998633765335677887655678 Q Ver_Hs_NP_0572 494 DVHAELDRITRKPVTVSPTTPTSPTEGEA 522 (523) Q Consensus 494 d~~~eldr~~~~~~~~~~~~~~~~~~~~~ 522 (523) ||+||||||+|+|+ .+++ ||+|| T Consensus 451 ~v~aeldr~trk~~-----t~~~-te~e~ 473 (473) T KOG3905 451 DVHAELDRITRKPV-----TPTS-TEGEA 473 (473) T ss_pred HHHHHHHHHHCCCC-----CCCC-CCCCC T ss_conf 89999887513777-----7776-55689 No 3 >KOG3929 Uncharacterized conserved protein [Function unknown] Probab=99.94 E-value=1.7e-26 Score=191.48 Aligned_columns=246 Identities=27% Q ss_pred CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCC--CCEEEEEECCC-HHCCHHH Q ss_conf 66545336799999988641445425787658897369976789999974201468886--52145640450-0004325 Q Ver_Hs_NP_0572 39 AGDDEDGQNLWSCILSEVSTRSRSKLPAGKNVLLLGEDGAGKTSLIRKIQGIEEYKKGR--GLEYLYLNVHD-EDRDDQT 115 (523) Q Consensus 39 ~~~~~~~~nlWssiL~~v~t~~~~klp~~KnILvLG~~~sGKTtLl~~Lq~~e~~kKg~--gLeY~Yl~V~D-eDrdd~a 115 (523) .|-..|-| |++|.++.- ..|+++|+++. |++|.+.--.++.++.- +|||+| -+. .-+.... T Consensus 29 nG~~~deq------L~e~~~~~E------~~I~~~Gn~~~--tt~I~~~FdR~e~~~~ptlaLEYty--gRR~~g~~~kd 92 (363) T KOG3929 29 NGSEGDEQ------LAEIAEKFE------FFIGSKGNGGK--TTIILRCFDRDEPPKPPTLALEYTY--GRRAKGHNPKD 92 (363) T ss_pred CCCHHHHH------HHHHHCCHH------CEEEEECCCCE--EEEEEECCCCCCCCCCCCEEEEEHH--HHHHCCCCCHH T ss_conf 23213789------998503002------05677338850--6653300576567899721221012--34414788514 Q ss_pred HCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC-----CCCHHHHHHHHHHH Q ss_conf 2463686586243245556787002666455655401013689999999999999999732-----78988999999999 Q Ver_Hs_NP_0572 116 RCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKL-----KIPPEEMKQMEQKL 190 (523) Q Consensus 116 r~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L-----~i~~ee~ke~~e~~ 190 (523) ..++|.|.|......||...++-.++.-+.+|++||||+|-.+|-.|..-++-+|.|++++ +..++...+|++++ T Consensus 93 iaN~WELGgg~~~~~LLsVPit~~~l~~~slIL~LDls~p~~~W~t~E~~~~~~R~~vd~~~~~~~k~~~~L~E~mrqR~ 172 (363) T KOG3929 93 IANFWELGGGTSLLDLLSVPITGDTLRTFSLILVLDLSKPNDLWPTMENLLQATRSHVDKVIMKLGKTNAKLVEEMRQRI 172 (363) T ss_pred HHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH T ss_conf 56555326732468886055455628775666765115624432579999999998999999987414889999999999 Q ss_pred HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHH Q ss_conf 99999850455566665534456766677653447888762300588327998507412555542057747899999999 Q Ver_Hs_NP_0572 191 IRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSH 270 (523) Q Consensus 191 i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~ 270 (523) + +.+.+.+.|....-|+ .||+++|..|+|.+ ++|..|...-+-|+ T Consensus 173 ~--------------------~rvgqd~~d~e~~dP~---------P~PV~IVgsKYDvF------q~FesekRkH~C~~ 217 (363) T KOG3929 173 W--------------------NRVGQDHPDHELIDPF---------PVPVVIVGSKYDVF------QDFESEKRKHICKT 217 (363) T ss_pred H--------------------HHHCCCCCCCCCCCCC---------CCCEEEECCCCHHH------CCCCHHHHHHHHHH T ss_conf 9--------------------8621468740002778---------85347853520001------26636789999999 Q ss_pred HHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHHHH Q ss_conf 99999971876888326636789999999998760655565564113640252688883788887 Q Ver_Hs_NP_0572 271 IRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKIGI 335 (523) Q Consensus 271 LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLygfpf~~~a~ViDrD~IfIPaGWDs~~KI~I 335 (523) ||..+..|||+|.+-|.|-++...++..-+-|.-||.+-...+.|+.-..+||-+|.|||++|++ T Consensus 218 LRf~Ah~yGaaLlmfSskMe~l~K~ir~~i~HlaFG~~~~~s~~vD~NkPlfi~~G~DS~~~IG~ 282 (363) T KOG3929 218 LRFVAHYYGAALLMFSSKMEALLKKIRGVINHLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGS 282 (363) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCHHHCCC T ss_conf 99999997789999888789999998777775404765766545307874589855532233378 No 4 >cd04128 Spg1 Spg1p. Spg1p (septum-promoting GTPase) was first identified in the fission yeast S. pombe, where it regulates septum formation in the septation initiation network (SIN) through the cdc7 protein kinase. Spg1p is an essential gene that localizes to the spindle pole bodies. When GTP-bound, it binds cdc7 and causes it to translocate to spindle poles. Sid4p (septation initiation defective) is required for localization of Spg1p to the spindle pole body, and the ability of Spg1p to promote septum formation from any point in the cell cycle depends on Sid4p. Spg1p is negatively regulated by Byr4 and cdc16, which form a two-component GTPase activating protein (GAP) for Spg1p. The existence of a SIN-related pathway in plants has been proposed. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are Probab=99.29 E-value=2.7e-11 Score=92.28 Aligned_columns=177 Identities=26% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.|+.. .+.+...-|++|.-..+.-++. .-.+.+|=..|...+.++.+.-..--+ .+ T Consensus 3 ivliGd~~VGKTsLi~r~~~~~F~~~y~~TiG~~~~~k~i~v~~~--~v~l~iwDtaGqE~f~~~~~~y~~~a~----~~ 76 (182) T cd04128 3 IGLLGDAQIGKTSLMVKYVEGEFDEDYIQTLGVNFMEKTISIRGT--EITFSIWDLGGQREFINMLPLVCNDAV----AI 76 (182) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEECCE--EEEEEEEECCCCCCCHHHHHHHCCCCC----EE T ss_conf 899816984388887776437127763550344678989998896--899887316888310127786403777----68 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+-++ +.+++|++.++.+-.. T Consensus 77 ilVfDit~~~Sf-~~i~~W~~~i~~~~~~--------------------------------------------------- 104 (182) T cd04128 77 LFMFDLTRKSTL-NSIKEWYRQARGFNKT--------------------------------------------------- 104 (182) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999865997899-9999999999862799--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCC Q ss_conf 88762300588327998507412555542057747899999999999999718768883266367899999999987606 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLYG 306 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLyg 306 (523) .+|| +|.+|+|.+. +...++-+.+....+.+|-++|+.+|+||+|.+.|++-+.+.+.-++|+ T Consensus 105 ----------~~~I-LVGNK~DL~~------~~~~~~~~~~~~~~~~~a~~~~~~~~etSAktg~nV~e~Fe~l~~ki~~ 167 (182) T cd04128 105 ----------AIPI-LVGTKYDLFA------DLPPEEQEEITKQARKYAKAMKAPLIFCSTSHSINVQKIFKIVLAKAFD 167 (182) T ss_pred ----------CCEE-EEECCCCCCC------CCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHC T ss_conf ----------6089-9832743100------1442456778899999999729959999724798878999999999853 Q ss_pred CCCCCCCCCCCCCEE Q ss_conf 555655641136402 Q Ver_Hs_NP_0572 307 FPYKIPAVVVEKDAV 321 (523) Q Consensus 307 fpf~~~a~ViDrD~I 321 (523) .+.+.|.+.---+.| T Consensus 168 ~~~~~~~~~~~~~~~ 182 (182) T cd04128 168 LPLTIPEILTVGEPI 182 (182) T ss_pred CCCCCCCCCCCCCCC T ss_conf 788877668888899 No 5 >cd00154 Rab Rab family. Rab GTPases form the largest family within the Ras superfamily. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. Rab GTPases are small, monomeric proteins that function as molecular switches to regulate vesicle trafficking pathways. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they regulate distinct steps in membrane traffic pathways. In the GTP-bound form, Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide di Probab=99.09 E-value=2.8e-10 Score=85.73 Aligned_columns=152 Identities=28% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+++...-+.+|..-.+. ......++.+|-..|...+..|.+..+.--+ .+ T Consensus 3 i~ivG~~~vGKTsli~~~~~~~f~~~~~~Ti~~~~~~k~i~--~~~~~~~~~i~Dt~g~e~~~~~~~~~~~~~d----~~ 76 (159) T cd00154 3 IVLIGDSGVGKTSLLLRFVDGKFDENYKSTIGVDFKSKTIE--IDGKTVKLQIWDTAGQERFRSITPSYYRGAH----GA 76 (159) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEE--ECCEEEEEEEEECCCCHHHHHHHHHHCCCCC----EE T ss_conf 89982699668999999863824744465310036888998--8895999999865997145677787514898----69 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||.|++.+.++ +.+++|++.++++... T Consensus 77 iiv~d~~~~~Sf-~~i~~~~~~i~~~~~~--------------------------------------------------- 104 (159) T cd00154 77 ILVYDITNRESF-ENLDKWLKELKEYAPE--------------------------------------------------- 104 (159) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999866997899-9999999999982699--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHH Q ss_conf 88762300588327998507412555542057747899999999999999718768883266367899999999 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYI 300 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl 300 (523) .+|+++|++|+|. +++..+.....|.+|-++++..+.||++.+.|++-+.+-| T Consensus 105 ----------~~piiivgnK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~e~Sa~~~~~i~~~F~~i 157 (159) T cd00154 105 ----------NIPIILVGNKIDL-----------EDQRQVSTEEAQQFAKENGLLFFETSAKTGENVEELFQSL 157 (159) T ss_pred ----------CCEEEEEECCCCH-----------HHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH T ss_conf ----------9789998413100-----------0102656889999999659969999704798878999997 No 6 >cd01868 Rab11_like Rab11-like. Rab11a, Rab11b, and Rab25 are closely related, evolutionary conserved Rab proteins that are differentially expressed. Rab11a is ubiquitously synthesized, Rab11b is enriched in brain and heart and Rab25 is only found in epithelia. Rab11/25 proteins seem to regulate recycling pathways from endosomes to the plasma membrane and to the trans-Golgi network. Furthermore, Rab11a is thought to function in the histamine-induced fusion of tubulovesicles containing H+, K+ ATPase with the plasma membrane in gastric parietal cells and in insulin-stimulated insertion of GLUT4 in the plasma membrane of cardiomyocytes. Overexpression of Rab25 has recently been observed in ovarian cancer and breast cancer, and has been correlated with worsened outcomes in both diseases. In addition, Rab25 overexpression has also been observed in prostate cancer, transitional cell carcinoma of the bladder, and invasive breast tumor cells. GTPase activating proteins (GAPs) interact with GTP Probab=99.09 E-value=3.2e-10 Score=85.32 Aligned_columns=159 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|+.++|||+|+.++..-+-..+... ++..|....=.-.+..-.+.+|=..|...+..+.+.-+.--+ .++| T Consensus 6 i~~iG~~~VGKTsli~r~~~~~F~~~~~~Tig~~~~~k~v~~~~~~~~l~iwDtaG~e~~~~~~~~~~~~a~----~~ii 81 (165) T cd01868 6 IVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQIDGKTIKAQIWDTAGQERYRAITSAYYRGAV----GALL 81 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCHHHHHHHHHHHCCCC----EEEE T ss_conf 999826996589999998638567455641001246889864890899998538986124577676504886----7999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|.+.+-++ +.+++|+..++++... T Consensus 82 vyDit~~~Sf-~~i~~w~~~i~~~~~~----------------------------------------------------- 107 (165) T cd01868 82 VYDITKKQTF-ENVERWLKELRDHADS----------------------------------------------------- 107 (165) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 9746997789-9999999999983289----------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 76230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) .+|+++|.+|+|. ++...+-.+-.+.+|.++|+..+.||+|...|++-+.+.|...+| T Consensus 108 --------~~piilVGNK~DL-----------~~~r~v~~~e~~~~a~~~~~~~~e~Sak~g~ni~~~F~~l~~~i~ 165 (165) T cd01868 108 --------NIVIMLVGNKSDL-----------RHLRAVPTEEAKAFAEKNGLSFIETSALDGTNVEEAFKQLLTEIY 165 (165) T ss_pred --------CCEEEEEECCCCH-----------HHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCC T ss_conf --------9379998216562-----------120377688999999965994999971479888899999998709 No 7 >cd00877 Ran Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases. Ran GTPase is involved in diverse biological functions, such as nuclear transport, spindle formation during mitosis, DNA replication, and cell division. Among the Ras superfamily, Ran is a unique small G protein. It does not have a lipid modification motif at the C-terminus to bind to the membrane, which is often observed within the Ras superfamily. Ran may therefore interact with a wide range of proteins in various intracellular locations. Like other GTPases, Ran exists in GTP- and GDP-bound conformations that interact differently with effectors. Conversion between these forms and the assembly or disassembly of effector complexes requires the interaction of regulator proteins. The intrinsic GTPase activity of Ran is very low, but it is greatly stimulated by a GTPase-activating protein (RanGAP1) located in the cytoplasm. By contrast, RCC1, a guanine nucleotide exchange factor that generates RanGTP, is Probab=99.07 E-value=1e-09 Score=82.01 Aligned_columns=157 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.|+.. .+++...-|.++....+..+.+.. ++.+|-..|...+.+|.+.-..--+ .+ T Consensus 3 IvliGd~~VGKTsli~r~~~~~F~~~y~~Tig~~~~~~~~~~~~~~i--~l~iwDtaG~e~f~~l~~~y~~~a~----~~ 76 (166) T cd00877 3 LVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLDFHTNRGKI--RFNVWDTAGQEKFGGLRDGYYIGGQ----CA 76 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEECCCEE--EEEEEECCCCCCCCCCCCCCCCCCC----EE T ss_conf 89982698448999888763811666453464488899999879479--9998845785213545512000267----58 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) |||-|.+.++++-. +.+|++-++.+... T Consensus 77 ilvfDit~~~Sf~~-i~~w~~~i~~~~~~--------------------------------------------------- 104 (166) T cd00877 77 IIMFDVTSRVTYKN-VPNWHRDLVRVCGN--------------------------------------------------- 104 (166) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 99986699789898-98899999864599--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCC Q ss_conf 88762300588327998507412555542057747899999999999999718768883266367899999999987606 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLYG 306 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLyg 306 (523) +|+++|++|+| |+.+....++. .++-++++..|-||+|.+.|++-+-.+|.-++.+ T Consensus 105 -----------ipivlVGNK~D----l~~~~~~~~~~---------~~~~~~~~~~~EtSAk~g~NV~e~F~~la~~il~ 160 (166) T cd00877 105 -----------IPIVLCGNKVD----IKDRKVKAKQI---------TFHRKKNLQYYEISAKSNYNFEKPFLWLARKLLG 160 (166) T ss_pred -----------CCEEEEECCCC----CCCCCCCHHHH---------HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHC T ss_conf -----------65899932677----32011248999---------9999579949999704898988999999999853 Q ss_pred CC Q ss_conf 55 Q Ver_Hs_NP_0572 307 FP 308 (523) Q Consensus 307 fp 308 (523) -| T Consensus 161 ~~ 162 (166) T cd00877 161 NP 162 (166) T ss_pred CC T ss_conf 78 No 8 >cd04122 Rab14 Rab14 subfamily. Rab14 GTPases are localized to biosynthetic compartments, including the rough ER, the Golgi complex, and the trans-Golgi network, and to endosomal compartments, including early endosomal vacuoles and associated vesicles. Rab14 is believed to function in both the biosynthetic and recycling pathways between the Golgi and endosomal compartments. Rab14 has also been identified on GLUT4 vesicles, and has been suggested to help regulate GLUT4 translocation. In addition, Rab14 is believed to play a role in the regulation of phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GT Probab=99.07 E-value=5.5e-10 Score=83.78 Aligned_columns=159 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|+.++|||+|+.++...+-..+-.. ++..|....=.-.+..-++.+|=..|...+.+|.+..+.--+ .++| T Consensus 5 ivviGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~i~~~~~~v~l~i~Dt~G~e~~~~~~~~~~~~a~----~~il 80 (166) T cd04122 5 YIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVNGQKIKLQIWDTAGQERFRAVTRSYYRGAA----GALM 80 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHCCCCC----EEEE T ss_conf 999826995589999887638436445621022146788852890899998635886023455386426987----5999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|.+.+=++ +.+++|+.-++.+... T Consensus 81 vydit~~~Sf-~~i~~w~~~~~~~~~~----------------------------------------------------- 106 (166) T cd04122 81 VYDITRRSTY-NHLSSWLTDARNLTNP----------------------------------------------------- 106 (166) T ss_pred EEECCCHHHH-HHHHHHHHHHHHCCCC----------------------------------------------------- T ss_conf 8207998789-9999999999740489----------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 76230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) .+|+++|++|+|. +++.++-..-.+.+|-++++..+.||+|.+.|++-+..++.-++| T Consensus 107 --------~~~iilVGNK~DL-----------~~~r~v~~~e~~~~a~~~~~~~~E~SAk~~~nV~e~F~~l~~~i~ 164 (166) T cd04122 107 --------NTVIFLIGNKADL-----------EAQRDVTYEEAKQFADENGLLFLECSAKTGENVEDAFLETAKKIY 164 (166) T ss_pred --------CCEEEEECCHHHH-----------HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------9579996372544-----------430354178999999964991999971589887899999999985 No 9 >cd01866 Rab2 Rab2 subfamily. Rab2 is localized on cis-Golgi membranes and interacts with Golgi matrix proteins. Rab2 is also implicated in the maturation of vesicular tubular clusters (VTCs), which are microtubule-associated intermediates in transport between the ER and Golgi apparatus. In plants, Rab2 regulates vesicle trafficking between the ER and the Golgi bodies and is important to pollen tube growth. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key featur Probab=99.05 E-value=2e-09 Score=80.14 Aligned_columns=157 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+.+...-+.+|....+.- .+...++.+|-..|...+..|.+.-....+ .+ T Consensus 7 ivliGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~i~~--~~~~v~l~iwDt~G~e~~~~l~~~~~~~a~----~~ 80 (168) T cd01866 7 YIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITI--DGKQIKLQIWDTAGQESFRSITRSYYRGAA----GA 80 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCC--CCCEEEEEEEECCCCCCHHHHHHHHCCCCC----EE T ss_conf 999816984389999998548257544530000001232146--784289998753888411245365347997----79 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+=++ +.++.|++.++++. T Consensus 81 iivfdvt~~~Sf-~~i~~w~~~~~~~~----------------------------------------------------- 106 (168) T cd01866 81 LLVYDITRRETF-NHLTSWLEDARQHS----------------------------------------------------- 106 (168) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHC----------------------------------------------------- T ss_conf 999766997789-99999999999736----------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 8876230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) +-.+|+++|.+|+| |+.++....++ .+.+|-++|+..+-||+|...|++-+...+.-.+| T Consensus 107 --------~~~~piilVGnK~D----L~~~r~v~~~e-------~~~~a~~~~~~~~E~SAkt~~nV~~~F~~la~~i~ 166 (168) T cd01866 107 --------NSNMTIMLIGNKCD----LESRREVSYEE-------GEAFAKEHGLIFMETSAKTASNVEEAFINTAKEIY 166 (168) T ss_pred --------CCCCEEEEEECCHH----HHHHCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------99968999833201----23304776889-------99999965984999861579887899999999997 No 10 >pfam00071 Ras Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices. Probab=99.04 E-value=8.8e-10 Score=82.43 Aligned_columns=159 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+|+|+.++|||+|+.++..-+-...-.. ++..+....=...+..-.+.+|-..|...+..|.+..+.--+ .++| T Consensus 2 i~viG~~~vGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~v~~~~~~~~l~i~Dt~g~e~~~~~~~~~~~~ad----~~il 77 (162) T pfam00071 2 LVLVGDGGVGKSSLLIRFTQNKFPEEYIPTIGVDFYTKTIEVDGKTVKLQIWDTAGQERFRSLRPAYYRGAQ----GFLL 77 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCCCC----EEEE T ss_conf 788817996689999998638327654420101578999987367999999866998013567586504898----8999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|++.. .=++.+++|+..++.+... T Consensus 78 vfd~~~~-~Sf~~i~~w~~~i~~~~~~----------------------------------------------------- 103 (162) T pfam00071 78 VYDITSR-DSFENVKKWLEEILRHADE----------------------------------------------------- 103 (162) T ss_pred EEECCCH-HHHHHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 9877997-8999999999999984599----------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 76230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) .+|+++|++|+|. ++...+-.+-.+.||-++++..+.||++...|++-+...|.-+|+ T Consensus 104 --------~~piilvgnK~Dl-----------~~~~~i~~~e~~~~~~~~~~~y~e~Sak~g~gI~e~F~~l~~~i~ 161 (162) T pfam00071 104 --------NVPIVLVGNKCDL-----------EDQRVVSTEEGEALAKELGLPFMETSAKTNTNVEEAFEELAREIL 161 (162) T ss_pred --------CCEEEEEEECCHH-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------9489998504201-----------121167688999999964995999971479888899999999980 No 11 >cd04119 RJL RJL (RabJ-Like) subfamily. RJLs are found in many protists and as chimeras with C-terminal DNAJ domains in deuterostome metazoa. They are not found in plants, fungi, and protostome metazoa, suggesting a horizontal gene transfer between protists and deuterostome metazoa. RJLs lack any known membrane targeting signal and contain a degenerate phosphate/magnesium-binding 3 (PM3) motif, suggesting an impaired ability to hydrolyze GTP. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Probab=99.02 E-value=2.1e-09 Score=80.02 Aligned_columns=162 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+++...-+.+|....|.-+++. .++.+|=..|...+..+.+....--+ .+ T Consensus 3 ivivGd~~vGKTsli~r~~~~~f~~~y~~Tig~~~~~k~i~~~~~~--~~l~iwDtaG~e~~~~~~~~~~~~a~----~~ 76 (168) T cd04119 3 VISMGNSGVGKSCIIKRYCEGRFVSKYLPTIGIDYGVKKVSVRNKE--VRVNFFDLSGHPEYLEVRNEFYKDTQ----GV 76 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEE--EEEEEEECCCCHHHHHHHHHHHCCCC----EE T ss_conf 8998079854899998877180166536503555556788887948--99998606898125788788723999----38 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+.++-. +++|+.-++.+..... T Consensus 77 ilvydit~~~Sf~~-i~~w~~~~~~~~~~~~------------------------------------------------- 106 (168) T cd04119 77 LLVYDVTDRQSFEA-LDSWLKEMKQEGGPHG------------------------------------------------- 106 (168) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCCCC------------------------------------------------- T ss_conf 99985699778999-9999999998605556------------------------------------------------- Q ss_pred CCCCCCCCCCC-CCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 88762300588-32799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLG-IPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLG-iPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) +.. +|+++|.+|+| |...+.-..++ .+.+|-++|+..|.||+|...|++.+..+|+..+. T Consensus 107 --------~~~~~~iilvGNK~D----l~~~r~V~~~~-------~~~~a~~~~~~~~E~SAk~~~nV~e~F~~l~~~i~ 167 (168) T cd04119 107 --------NMENIVVVVCANKID----LTKHRAVSEDE-------GRLWAESKGFKYFETSACTGEGVNEMFQTLFSSIV 167 (168) T ss_pred --------CCCCCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHC T ss_conf --------668747999705323----32357679899-------99999964991999971589787899999999855 Q ss_pred C Q ss_conf 6 Q Ver_Hs_NP_0572 306 G 306 (523) Q Consensus 306 g 306 (523) . T Consensus 168 d 168 (168) T cd04119 168 D 168 (168) T ss_pred C T ss_conf 9 No 12 >cd04106 Rab23_lke Rab23-like subfamily. Rab23 is a member of the Rab family of small GTPases. In mouse, Rab23 has been shown to function as a negative regulator in the sonic hedgehog (Shh) signalling pathway. Rab23 mediates the activity of Gli2 and Gli3, transcription factors that regulate Shh signaling in the spinal cord, primarily by preventing Gli2 activation in the absence of Shh ligand. Rab23 also regulates a step in the cytoplasmic signal transduction pathway that mediates the effect of Smoothened (one of two integral membrane proteins that are essential components of the Shh signaling pathway in vertebrates). In humans, Rab23 is expressed in the retina. Mice contain an isoform that shares 93% sequence identity with the human Rab23 and an alternative splicing isoform that is specific to the brain. This isoform causes the murine open brain phenotype, indicating it may have a role in the development of the central nervous system. GTPase activating proteins (GAPs) interact with G Probab=99.02 E-value=7.2e-10 Score=83.01 Aligned_columns=156 Identities=28% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+++...-|.+|.--.|.-+++...-++.+|-..|...+..|.+....--+ .+ T Consensus 3 i~~iGd~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~v~v~~~~~~v~l~iwDt~g~e~~~~~~~~~~~~~~----~~ 78 (162) T cd04106 3 VIVVGNGNVGKSSMIQRFVKGIFTKDYKKTIGVDFLEKQIFLRQSDEDVRLMLWDTAGQEEFDAITKAYYRGAQ----AC 78 (162) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCCHHHHHHHHHCCCCC----EE T ss_conf 89980798448999999862822755564101046777899700884799998718888003455376414897----89 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+.++ +.++.|..-+++.... T Consensus 79 llvydvt~~~Sf-~~i~~w~~~i~~~~~~--------------------------------------------------- 106 (162) T cd04106 79 ILVFSTTDRESF-EAIESWKEKVEAECGD--------------------------------------------------- 106 (162) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999866997899-9999999999985499--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHH Q ss_conf 88762300588327998507412555542057747899999999999999718768883266367899999999987 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQK 303 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~Hr 303 (523) +|+++|.+|+|.. ++..+..+-.+.+|-++++..+.||+|.+.|++-+.++|.-+ T Consensus 107 -----------~p~ilVGNK~Dl~-----------~~~~vs~~~~~~~a~~~~~~~~E~SAk~~~nV~e~F~~la~k 161 (162) T cd04106 107 -----------IPMVLVQTKIDLL-----------DQAVITNEEAEALAKRLQLPLFRTSVKDDFNVTELFEYLAEK 161 (162) T ss_pred -----------CEEEEEECCCCCC-----------CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHH T ss_conf -----------3799982142321-----------246589899999999669959999715898878999999850 No 13 >cd00876 Ras Ras family. The Ras family of the Ras superfamily includes classical N-Ras, H-Ras, and K-Ras, as well as R-Ras, Rap, Ral, Rheb, Rhes, ARHI, RERG, Rin/Rit, RSR1, RRP22, Ras2, Ras-dva, and RGK proteins. Ras proteins regulate cell growth, proliferation and differentiation. Ras is activated by guanine nucleotide exchange factors (GEFs) that release GDP and allow GTP binding. Many RasGEFs have been identified. These are sequestered in the cytosol until activation by growth factors triggers recruitment to the plasma membrane or Golgi, where the GEF colocalizes with Ras. Active GTP-bound Ras interacts with several effector proteins: among the best characterized are the Raf kinases, phosphatidylinositol 3-kinase (PI3K), RalGEFs and NORE/MST1. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of m Probab=99.02 E-value=7.3e-10 Score=82.99 Aligned_columns=159 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.++..-+-...-..---.+....-...+..-++.+|-..|...+..+.+..+.--+ .++|| T Consensus 2 i~~iGd~~vGKTsli~r~~~~~f~~~~~~ti~~~~~k~~~~~~~~~~l~i~Dt~G~e~~~~~~~~~~~~a~----~~iiv 77 (160) T cd00876 2 VVVLGAGGVGKSAITIQFVKGTFVEEYDPTIEDSYRKTIVVDGETYTLDILDTAGQEEFSAMRDLYIRQGD----GFILV 77 (160) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHCCCC----EEEEE T ss_conf 78880799668999999872810675354200226778888482899998635884133468887640461----78999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+.++ +.+++|+.-+++....-++ T Consensus 78 fdi~~~~Sf-~~i~~w~~~i~~~~~~~~~--------------------------------------------------- 105 (160) T cd00876 78 YSITDRESF-EEIKGYREQILRVKDDEDI--------------------------------------------------- 105 (160) T ss_pred EECCCHHHH-HHHHHHHHHHHHHCCCCCC--------------------------------------------------- T ss_conf 866997799-9999999999985389996--------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) |+++|++|+|.. ++..+-.+-.+.||-++++..+.||+|.+.|++-+...|.-.+ T Consensus 106 ---------piilvgNK~Dl~-----------~~r~v~~~e~~~~a~~~~~~~~e~Sak~~~nV~~~F~~i~~~i 160 (160) T cd00876 106 ---------PIVLVGNKCDLE-----------NERQVSKEEGKALAKEWGCPFIETSAKDNINIDEVFKLLVREI 160 (160) T ss_pred ---------EEEEEECCCCCH-----------HHCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHC T ss_conf ---------799982132630-----------0116768899999996499699997048988889999999829 No 14 >cd04101 RabL4 RabL4 (Rab-like4) subfamily. RabL4s are novel proteins that have high sequence similarity with Rab family members, but display features that are distinct from Rabs, and have been termed Rab-like. As in other Rab-like proteins, RabL4 lacks a prenylation site at the C-terminus. The specific function of RabL4 remains unknown. Probab=99.00 E-value=1.2e-09 Score=81.64 Aligned_columns=157 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHHHC-----CCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHH Q ss_conf 889736997678999997420-----146888652145640450000432524636865862432455567870026664 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGI-----EEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDT 144 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~-----e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~T 144 (523) |+++|+.++|||+|+.++... +.+...-+.+|..-.+.=.+.+ .-.+.+|=..|...+..+.+.-..--+ T Consensus 3 vv~iGd~~VGKTsli~~~~~~~~~f~~~y~~T~~~~~~~~~~~i~~~~-~~~l~i~DtaGqe~~~~~~~~~~~~a~---- 77 (164) T cd04101 3 CAVVGDPAVGKTAFVQMFHSNGAVFPKNYLMTTGCDFVVKEVPVDTDN-TVELFIFDSAGQELYSDMVSNYWESPS---- 77 (164) T ss_pred EEEEECCCCCHHHHHHHHHHCCCEECCCCCCCEEEEEEEEEEEECCCC-EEEEEEEECCCCHHHHHHHHHHCCCCC---- T ss_conf 899807982189888877616844166654311245679999977996-799999603872246788787424997---- Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 55655401013689999999999999999732789889999999999999985045556666553445676667765344 Q Ver_Hs_NP_0572 145 LVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVV 224 (523) Q Consensus 145 LVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~ 224 (523) .++||-|.+.+.++ +.+.+|+.-++.+- T Consensus 78 ~~ilvydit~~~Sf-~~i~~w~~~i~~~~--------------------------------------------------- 105 (164) T cd04101 78 VFILVYDVSNKASF-ENCSRWVNKVRTAS--------------------------------------------------- 105 (164) T ss_pred EEEEEEECCCHHHH-HHHHHHHHHHHHHC--------------------------------------------------- T ss_conf 69999417997689-99999999999844--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 78887623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 225 VPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 225 lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) -.+|+++|++|+|. .++..+-..-.|.+|-.+++..+.||+|...|++.+...|.-.. T Consensus 106 -----------~~~p~ilVGNK~DL-----------~~~r~V~~~~~~~~a~~~~~~~~e~SAktg~nV~e~F~~lar~~ 163 (164) T cd04101 106 -----------KHMPGVLVGNKMDL-----------ADKAEVTDAQAQAFAQANQLKFFKTSALRGVGYEEPFESLARAF 163 (164) T ss_pred -----------CCCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH T ss_conf -----------99739998214340-----------01167898999999996399499997168988789999999972 Q ss_pred C Q ss_conf 0 Q Ver_Hs_NP_0572 305 Y 305 (523) Q Consensus 305 y 305 (523) + T Consensus 164 ~ 164 (164) T cd04101 164 H 164 (164) T ss_pred C T ss_conf 9 No 15 >cd04108 Rab36_Rab34 Rab34/Rab36 subfamily. Rab34, found primarily in the Golgi, interacts with its effector, Rab-interacting lysosomal protein (RILP). This enables its participation in microtubular dynenin-dynactin-mediated repositioning of lysosomes from the cell periphery to the Golgi. A Rab34 (Rah) isoform that lacks the consensus GTP-binding region has been identified in mice. This isoform is associated with membrane ruffles and promotes macropinosome formation. Rab36 has been mapped to human chromosome 22q11.2, a region that is homozygously deleted in malignant rhabdoid tumors (MRTs). However, experimental assessments do not implicate Rab36 as a tumor suppressor that would enable tumor formation through a loss-of-function mechanism. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further re Probab=99.00 E-value=1.3e-09 Score=81.31 Aligned_columns=163 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|+.++|||+|+.|+..-+-..+-.. ++.-|..-.=.-.+..-.+.+|=..|...+.++.+....--+ .+|| T Consensus 3 ivliGd~~VGKTsli~rf~~~~f~~~y~~Tig~d~~~k~~~~~~~~i~l~iwDtaG~e~~~~~~~~~~~~a~----~~il 78 (170) T cd04108 3 VIVVGDLSVGKTCLINRFCKDVFDKNYKATIGVDFEMERFEILGVPFSLQLWDTAGQERFKCIASTYYRGAQ----AIII 78 (170) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHCCCCC----EEEE T ss_conf 899816985489988887628227862442566788998751883799998536886024566675404888----0899 Q ss_pred HHHHHHHHHHHHHHHHHH-HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 540101368999999999-9999999732789889999999999999985045556666553445676667765344788 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWA-SVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPL 227 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi-~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPL 227 (523) |-|.+.+.++ +.+++|+ .+++.+-.+ T Consensus 79 vyDit~~~Sf-~~~~~w~~~~~~~~~~~---------------------------------------------------- 105 (170) T cd04108 79 VFDLTDVASL-EHTRQWLEDALKENDPS---------------------------------------------------- 105 (170) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHHCCC---------------------------------------------------- T ss_conf 9754986578-99999999998740799---------------------------------------------------- Q ss_pred CCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCC Q ss_conf 87623005883279985074125555420577478999999999999997187688832663678999999999876065 Q Ver_Hs_NP_0572 228 GADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLYGF 307 (523) Q Consensus 228 geg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLygf 307 (523) .+|+++|.+|+|..+ .++..++.+.-+.++-++|+..|.||+|.+.|++-+...|.-.+|.+ T Consensus 106 ---------~~~i~LVGnK~DL~~---------~~~~~~~~~~~~~~a~~~~~~~fEtSAktg~nV~e~F~~ia~~~~~~ 167 (170) T cd04108 106 ---------SVLLFLVGTKKDLSS---------PAQYALMEQDAIKLAAEMQAEYWSVSALSGENVREFFFRVAALTFEL 167 (170) T ss_pred ---------CCEEEEEECCCCCCC---------CCCCEECHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHC T ss_conf ---------968999835601045---------31120037899999996599599997258878789999999999850 No 16 >cd04109 Rab28 Rab28 subfamily. First identified in maize, Rab28 has been shown to be a late embryogenesis-abundant (Lea) protein that is regulated by the plant hormone abcisic acid (ABA). In Arabidopsis, Rab28 is expressed during embryo development and is generally restricted to provascular tissues in mature embryos. Unlike maize Rab28, it is not ABA-inducible. Characterization of the human Rab28 homolog revealed two isoforms, which differ by a 95-base pair insertion, producing an alternative sequence for the 30 amino acids at the C-terminus. The two human isoforms are presumbly the result of alternative splicing. Since they differ at the C-terminus but not in the GTP-binding region, they are predicted to be targeted to different cellular locations. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs Probab=98.99 E-value=2e-09 Score=80.18 Aligned_columns=170 Identities=27% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+.+...-|++|.--.+. -+....-.+++|-..|...+..++..-+.--+ .+ T Consensus 3 VvliGd~~VGKTSLi~rf~~~~F~~~y~~Tig~d~~~k~i~-i~~~~~v~l~iwDtaGqe~~~~~~~~y~~~a~----~~ 77 (215) T cd04109 3 IVVLGDGAVGKTSLCRRFAKEGFGKSYKQTIGLDFFSKRVT-LPGNLNVTLQVWDIGGQSIGGKMLDKYIYGAH----AV 77 (215) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEE-ECCCCEEEEEEEECCCCCHHHHHHHHHHCCCC----EE T ss_conf 89982698538999988770721776465145678789999-75860589999864773023688998705998----48 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+.+| +.|+.|+..+++....-. T Consensus 78 ilVYdIt~~~SF-~~i~~W~~~i~~~~~~~~------------------------------------------------- 107 (215) T cd04109 78 FLVYDVTNSQSF-ENLEDWYSMVRKVLKSSE------------------------------------------------- 107 (215) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHHHCCC------------------------------------------------- T ss_conf 999753897689-999999999998731058------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCC Q ss_conf 88762300588327998507412555542057747899999999999999718768883266367899999999987606 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLYG 306 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLyg 306 (523) -.++|++|.+|+|. +++..+-..-.+.||-++|+..|.||+|...|++.+...|.-++.| T Consensus 108 ---------~~~~iiLVGNK~DL-----------~~~R~Vs~ee~~~~A~~~~~~f~EvSAktg~nV~elF~~la~~i~~ 167 (215) T cd04109 108 ---------TQPLVVLVGNKTDL-----------EHNRTVKDDKHARFAQANGMESCLVSAKTGDRVNLLFQQLAAELLG 167 (215) T ss_pred ---------CCCEEEEECCCCCH-----------HHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHC T ss_conf ---------98189996054240-----------1206679899999999649959999626798888999999999808 Q ss_pred CCCCCCCC Q ss_conf 55565564 Q Ver_Hs_NP_0572 307 FPYKIPAV 314 (523) Q Consensus 307 fpf~~~a~ 314 (523) ...+..+. T Consensus 168 ~~~~~~~~ 175 (215) T cd04109 168 VDLSKAEL 175 (215) T ss_pred CCCCHHHC T ss_conf 63110104 No 17 >cd01863 Rab18 Rab18 subfamily. Mammalian Rab18 is implicated in endocytic transport and is expressed most highly in polarized epithelial cells. However, trypanosomal Rab, TbRAB18, is upregulated in the BSF (Blood Stream Form) stage and localized predominantly to elements of the Golgi complex. In human and mouse cells, Rab18 has been identified in lipid droplets, organelles that store neutral lipids. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of mos Probab=98.99 E-value=2.1e-09 Score=79.99 Aligned_columns=156 Identities=27% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+++...-+.+|.-..+.-+.+. -++.+|=..|...+..|.+.-..--+ .+ T Consensus 3 iv~iG~~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~i~~~~~~--~~l~iwDt~G~e~~~~l~~~~~~~~~----~~ 76 (161) T cd01863 3 ILLIGDSGVGKSSLLLRFTDDTFDPDLAATIGVDFKVKTLTVDGKK--VKLAIWDTAGQERFRTLTSSYYRGAQ----GV 76 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEE--EEEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 8998079965899999986282077656510002458899898969--99999754887101245475435998----79 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+ .=.+.+++|+.-++ T Consensus 77 i~vfd~t~~-~Sf~~i~~w~~~i~-------------------------------------------------------- 99 (161) T cd01863 77 ILVYDVTRR-DTFTNLETWLNELE-------------------------------------------------------- 99 (161) T ss_pred EEEEECCCH-HHHHHHHHHHHHHH-------------------------------------------------------- T ss_conf 999856986-79999999999999-------------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 887623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) ....+-.+|+++|.+|+|. +...+...-.+.+|.++|+-.+.||++.+.|++-+...|..++ T Consensus 100 ----~~~~~~~~~~ilvGNK~Dl------------~~r~v~~~e~~~~a~~~~~~~~e~SAk~~~nv~e~F~~l~~~i 161 (161) T cd01863 100 ----TYSTNNDIVKMLVGNKIDK------------ENREVTREEGLKFARKHNMLFIETSAKTRDGVQQAFEELVEKI 161 (161) T ss_pred ----HHCCCCCCEEEEECCCCCC------------CCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC T ss_conf ----7338999389996123343------------0004888899999996699299997058978789999999849 No 18 >cd04116 Rab9 Rab9 subfamily. Rab9 is found in late endosomes, together with mannose 6-phosphate receptors (MPRs) and the tail-interacting protein of 47 kD (TIP47). Rab9 is a key mediator of vesicular transport from late endosomes to the trans-Golgi network (TGN) by redirecting the MPRs. Rab9 has been identified as a key component for the replication of several viruses, including HIV1, Ebola, Marburg, and measles, making it a potential target for inhibiting a variety of viruses. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CX Probab=98.98 E-value=2.8e-09 Score=79.13 Aligned_columns=161 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|+.++|||+|+.++..-+-..+... ++..|....-.-......+.+|-..|...+..|.+....--+ .++| T Consensus 8 ivliGd~~vGKTsLi~rf~~~~f~~~~~~tig~~~~~k~i~~~~~~~~l~i~Dtag~e~~~~l~~~~~~~~~----~~ii 83 (170) T cd04116 8 VILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDGHFVTLQIWDTAGQERFRSLRTPFYRGSD----CCLL 83 (170) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEECCEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCC----EEEE T ss_conf 999807995489999887538117773473231102200004796489998707898101231157631898----4899 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|.+.+.++-. +..|+.-+..+.+.-. T Consensus 84 vydit~~~Sf~~-i~~w~~e~~~~~~~~~--------------------------------------------------- 111 (170) T cd04116 84 TFAVDDSQSFQN-LSNWKKEFIYYADVKE--------------------------------------------------- 111 (170) T ss_pred EEECCCHHHHHH-HHHHHHHHHHHCCCCC--------------------------------------------------- T ss_conf 985499768999-9999999998603577--------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHHHHH Q ss_conf 76230058832799850741255554205774789999999999999971876888-32663678999999999876 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~HrL 304 (523) .=.+|+++|++|+|. ++..+...-.+.+|-++|...+| ||++.+.|++.+...+..++ T Consensus 112 ------~~~ipiilVGNK~DL------------~~r~V~~~e~~~~~~~~~~~~~~E~SAk~g~nv~~~F~~l~r~i 170 (170) T cd04116 112 ------PESFPFVVLGNKNDI------------PERQVSTEEAQAWCRENGDYPYFETSAKDATNVAAAFEEAVRRV 170 (170) T ss_pred ------CCCCEEEEEECCCCC------------HHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCC T ss_conf ------897079998354220------------11101178999999970797178986048988789999998509 No 19 >cd04123 Rab21 Rab21 subfamily. The localization and function of Rab21 are not clearly defined, with conflicting data reported. Rab21 has been reported to localize in the ER in human intestinal epithelial cells, with partial colocalization with alpha-glucosidase, a late endosomal/lysosomal marker. More recently, Rab21 was shown to colocalize with and affect the morphology of early endosomes. In Dictyostelium, GTP-bound Rab21, together with two novel LIM domain proteins, LimF and ChLim, has been shown to regulate phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site Probab=98.98 E-value=2.2e-09 Score=79.88 Aligned_columns=156 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+.+...-+.+|..-.+.-+++. ..+++|-..|...+..|.+.-+.--. .+ T Consensus 3 i~~iGd~~vGKTsli~r~~~~~f~~~~~~ti~~~~~~k~i~~~~~~--~~l~iwDt~G~~~~~~~~~~~~~~a~----~~ 76 (162) T cd04123 3 VVLLGEGRVGKTSLVLRYVENKFNEKHESTTQASFFQKTVNIGGKR--IDLAIWDTAGQERYHALGPIYYRDAD----GA 76 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCE--EEEEEEECCCCHHHHHHHHHHHCCCC----EE T ss_conf 8998269965899999986281177645411244135533159938--99997307875023566576614898----68 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+.++-. +++|+.-++++... T Consensus 77 ilvydit~~~Sf~~-i~~w~~~i~~~~~~--------------------------------------------------- 104 (162) T cd04123 77 ILVYDITDADSFQK-VKKWIKELKQMRGN--------------------------------------------------- 104 (162) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 99942798778999-99999989973189--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 887623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) .+|+++|++|+|. +++..+=.+-.+.+|-++|+..+-||+|.+.|++-+...|.-++ T Consensus 105 ----------~~piilVGNK~Dl-----------~~~r~V~~~~~~~~a~~~~~~~~E~Sak~~~nv~e~F~~l~~~i 161 (162) T cd04123 105 ----------NISLVIVGNKIDL-----------ERQRVVSKSEAEEYAKSVGAKHFETSAKTGKGIEELFLSLAKRM 161 (162) T ss_pred ----------CCEEEEEEEHHHH-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH T ss_conf ----------9659998400231-----------21025477899999996499389997158978789999999982 No 20 >cd01865 Rab3 Rab3 subfamily. The Rab3 subfamily contains Rab3A, Rab3B, Rab3C, and Rab3D. All four isoforms were found in mouse brain and endocrine tissues, with varying levels of expression. Rab3A, Rab3B, and Rab3C localized to synaptic and secretory vesicles; Rab3D was expressed at high levels only in adipose tissue, exocrine glands, and the endocrine pituitary, where it is localized to cytoplasmic secretory granules. Rab3 appears to control Ca2+-regulated exocytosis. The appropriate GDP/GTP exchange cycle of Rab3A is required for Ca2+-regulated exocytosis to occur, and interaction of the GTP-bound form of Rab3A with effector molecule(s) is widely believed to be essential for this process. Functionally, most studies point toward a role for Rab3 in the secretion of hormones and neurotransmitters. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promot Probab=98.98 E-value=4.2e-09 Score=78.01 Aligned_columns=156 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.|+.. .+.+...-+.+|..-.+...+.. -.+.+|=..|...+..+.+..+.--. .+ T Consensus 4 iilvGd~~VGKTsli~rf~~~~f~~~y~~Ti~~~~~~k~i~~~~~~--v~l~iwDt~G~e~~~~~~~~~~~~~~----~~ 77 (165) T cd01865 4 LLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRNDKR--VKLQIWDTAGQERYRTITTAYYRGAM----GF 77 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCEEEEEEEEEEEECCEE--EEEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 9998079953899888764481066634303656789999877938--99999745887013456564336998----89 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+-++ +.+.+|++-++.+-.. T Consensus 78 iivfd~t~~~Sf-~~i~~w~~~i~~~~~~--------------------------------------------------- 105 (165) T cd01865 78 ILMYDITNEESF-NAVQDWSTQIKTYSWD--------------------------------------------------- 105 (165) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999866986689-9999999999860699--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 887623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) .+|+++|.+|+|. +++..+-..-.+.+|-++|...|.||+|.+.|++.+...|...+ T Consensus 106 ----------~~~iilVGNK~Dl-----------~~~r~v~~~~~~~~a~~~~~~y~EtSAk~~~nV~e~F~~l~~~i 162 (165) T cd01865 106 ----------NAQVILVGNKCDM-----------EDERVVSSERGRQLADQLGFEFFEASAKENINVKQVFERLVDII 162 (165) T ss_pred ----------CEEEEEEECCCCH-----------HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH T ss_conf ----------6089997217772-----------46553138899999996599499997158988789999999998 No 21 >cd04112 Rab26 Rab26 subfamily. First identified in rat pancreatic acinar cells, Rab26 is believed to play a role in recruiting mature granules to the plasma membrane upon beta-adrenergic stimulation. Rab26 belongs to the Rab functional group III, which are considered key regulators of intracellular vesicle transport during exocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=98.97 E-value=2e-09 Score=80.11 Aligned_columns=156 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHH----CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHH Q ss_conf 88973699767899999742----01468886521456404500004325246368658624324555678700266645 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG----IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTL 145 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~----~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TL 145 (523) |+++|+.++|||+|+.|+.. -+.+...-|.+|....+.-++.. .++.+|=..|...+.+|.+.-..--+ . T Consensus 3 Iv~iGd~~VGKTsli~r~~~~~f~~~~~~~Tig~~~~~k~i~~~~~~--i~l~iwDtaGqe~~~~l~~~yy~~a~----~ 76 (191) T cd04112 3 VMLLGDSGVGKTCLLVRFKDGAFLNGNFIATVGIDFRNKVVTVDGVK--VKLQIWDTAGQERFRSVTHAYYRDAH----A 76 (191) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEECCEE--EEEEEEECCCCHHHHHHHHHHHCCCC----E T ss_conf 89982699548999988762822587634211100367789887938--99998755887012455366613897----7 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 56554010136899999999999999997327898899999999999999850455566665534456766677653447 Q Ver_Hs_NP_0572 146 VMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVV 225 (523) Q Consensus 146 VvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~l 225 (523) ++||-|.+.+.+|-. |..|+.-++++... T Consensus 77 ~iivyDit~~~Sf~~-i~~w~~~i~~~~~~-------------------------------------------------- 105 (191) T cd04112 77 LLLLYDITNKASFDN-IRAWLTEIKEYAQE-------------------------------------------------- 105 (191) T ss_pred EEEEEECCCHHHHHH-HHHHHHHHHHHCCC-------------------------------------------------- T ss_conf 999987799789999-99999988852699-------------------------------------------------- Q ss_pred CCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 8887623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 226 PLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 226 PLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) .+|+++|.+|+|. +++..+-.+-.+.+|-++|+..|.||+|.+.|++-+..+|...+ T Consensus 106 -----------~~~ivlVGNK~DL-----------~~~r~V~~~e~~~~a~~~~~~~~EtSAk~~~nI~e~F~~l~~~i 162 (191) T cd04112 106 -----------DVVIMLLGNKADM-----------SGERVVKREDGERLAKEYGVPFMETSAKTGLNVELAFTAVAKEL 162 (191) T ss_pred -----------CCEEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH T ss_conf -----------9489998632776-----------32255388999999996699599996258988889999999999 No 22 >cd04115 Rab33B_Rab33A Rab33B/Rab33A subfamily. Rab33B is ubiquitously expressed in mouse tissues and cells, where it is localized to the medial Golgi cisternae. It colocalizes with alpha-mannose II. Together with the other cisternal Rabs, Rab6A and Rab6A', it is believed to regulate the Golgi response to stress and is likely a molecular target in stress-activated signaling pathways. Rab33A (previously known as S10) is expressed primarily in the brain and immune system cells. In humans, it is located on the X chromosome at Xq26 and its expression is down-regulated in tuberculosis patients. Experimental evidence suggests that Rab33A is a novel CD8+ T cell factor that likely plays a role in tuberculosis disease processes. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine Probab=98.96 E-value=2.3e-09 Score=79.76 Aligned_columns=157 Identities=26% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCC-CCCCCCCCCCCHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243-24555678700266645 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYH-KGLLKFSLDAVSLKDTL 145 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~-~~LLK~aLt~~si~~TL 145 (523) |+++|+.++|||+|+.|+.. .+.+...-|.+|..-.+.=+ +..-++.+|-..|...+ .+|.+....--+ . T Consensus 5 ivliGd~~VGKTsli~r~~~~~F~~~~~~Tig~d~~~k~i~~~--~~~v~l~iwDtaGqe~f~~~l~~~y~~~a~----~ 78 (170) T cd04115 5 IIVIGDSNVGKTCLTYRFCAGRFPERTEATIGVDFRERTVEID--GERIKVQLWDTAGQERFRKSMVQHYYRNVH----A 78 (170) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC--CEEEEEEEECCCCCHHHHHHHHHHHCCCCC----E T ss_conf 9998079965899999986285575445312203578999988--958999982278733567777654304898----4 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 56554010136899999999999999997327898899999999999999850455566665534456766677653447 Q Ver_Hs_NP_0572 146 VMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVV 225 (523) Q Consensus 146 VvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~l 225 (523) ++||-|.+.+.++-. +..|+.-++.+...-.+ T Consensus 79 ~ilvydit~~~SF~~-i~~w~~~i~~~~~~~~~----------------------------------------------- 110 (170) T cd04115 79 VVFVYDVTNMASFHS-LPSWIEECEQHSLPNEV----------------------------------------------- 110 (170) T ss_pred EEEEEECCCHHHHHH-HHHHHHHHHHHCCCCCC----------------------------------------------- T ss_conf 899987699778899-99999999972599861----------------------------------------------- Q ss_pred CCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCC---CHHHHHHHHHHHHH Q ss_conf 888762300588327998507412555542057747899999999999999718768883266---36789999999998 Q Ver_Hs_NP_0572 226 PLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVK---ENKNIDLVYKYIVQ 302 (523) Q Consensus 226 PLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~k---e~knl~LLykYl~H 302 (523) |+++|++|+|. +++..+-..-.+.+|-++|+..|-||+| ++.|++.+...|.. T Consensus 111 -------------p~iLVGNK~DL-----------~~~r~Vs~~e~~~~A~~~~~~~fE~SAK~~~~~~nV~~~F~~la~ 166 (170) T cd04115 111 -------------PRILVGNKCDL-----------REQIQVPTDLAQRFADAHSMPLFETSAKDPSENDHVEAIFMTLAH 166 (170) T ss_pred -------------EEEEEECCCCC-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHH T ss_conf -------------79998021350-----------121367989999999966995999862678888687899999999 Q ss_pred HH Q ss_conf 76 Q Ver_Hs_NP_0572 303 KL 304 (523) Q Consensus 303 rL 304 (523) +| T Consensus 167 ~l 168 (170) T cd04115 167 KL 168 (170) T ss_pred HH T ss_conf 96 No 23 >cd04113 Rab4 Rab4 subfamily. Rab4 has been implicated in numerous functions within the cell. It helps regulate endocytosis through the sorting, recycling, and degradation of early endosomes. Mammalian Rab4 is involved in the regulation of many surface proteins including G-protein-coupled receptors, transferrin receptor, integrins, and surfactant protein A. Experimental data implicate Rab4 in regulation of the recycling of internalized receptors back to the plasma membrane. It is also believed to influence receptor-mediated antigen processing in B-lymphocytes, in calcium-dependent exocytosis in platelets, in alpha-amylase secretion in pancreatic cells, and in insulin-induced translocation of Glut4 from internal vesicles to the cell surface. Rab4 is known to share effector proteins with Rab5 and Rab11. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to p Probab=98.94 E-value=2.3e-09 Score=79.72 Aligned_columns=158 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|+.++|||+|+.++..-+-..+... ++..|....=...+....+.+|=..|...+..|.+....--+ .++| T Consensus 3 iviiGd~~VGKTsli~~~~~~~f~~~~~~Tig~~~~~~~i~~~~~~~~l~i~Dt~G~e~~~~l~~~~~~~a~----~~ii 78 (161) T cd04113 3 FIIIGSSGTGKSCLLHRFVENKFKEDSQHTIGVEFGSKIIRVGGKRVKLQIWDTAGQERFRSVTRSYYRGAA----GALL 78 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCCCC----EEEE T ss_conf 899826985589999998628106665641012013589988896999998325887013455586426997----7999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|.+.+.++ +.+++|+.-++.+... T Consensus 79 vydi~~~~Sf-~~i~~w~~~~~~~~~~----------------------------------------------------- 104 (161) T cd04113 79 VYDITNRTSF-EALPTWLSDARALASP----------------------------------------------------- 104 (161) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 9855986689-9999999999872489----------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 7623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) .+|+++|++|+|. .+...+=..-.+.+|-++|...+.||+|...|++-+...|.-.+ T Consensus 105 --------~~~iilvgNK~DL-----------~~~r~v~~~e~~~~a~~~~~~~~e~Sak~~~ni~e~F~~lar~i 161 (161) T cd04113 105 --------NIVVILVGNKSDL-----------ADQREVTFLEASRFAQENGLLFLETSALTGENVEEAFLKCARSI 161 (161) T ss_pred --------CCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC T ss_conf --------9689998324564-----------21334588999999996599099997158988889999999829 No 24 >cd04110 Rab35 Rab35 subfamily. Rab35 is one of several Rab proteins to be found to participate in the regulation of osteoclast cells in rats. In addition, Rab35 has been identified as a protein that interacts with nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) in human cells. Overexpression of NPM-ALK is a key oncogenic event in some anaplastic large-cell lymphomas; since Rab35 interacts with N|PM-ALK, it may provide a target for cancer treatments. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is Probab=98.92 E-value=4.9e-09 Score=77.60 Aligned_columns=156 Identities=25% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.|+.. .+.+...-|.+|....|.-+++. .++.+|=..|...+.+|.+.-..--+ .+ T Consensus 9 vv~iGd~~VGKTsli~r~~~~~F~~~y~~Tig~~~~~k~v~i~~~~--~~l~iwDtaGqe~~~~l~~~y~~~a~----~~ 82 (199) T cd04110 9 LLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEINGER--VKLQIWDTAGQERFRTITSTYYRGTH----GV 82 (199) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCEEEEEEEEEEEECCEE--EEEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 9998269843899998876180076646511223578889985839--99999866997035677676503898----79 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) |||-|.+.+.+| +.|.+|+..++.+... T Consensus 83 ilVydit~~~Sf-~~i~~w~~~i~~~~~~--------------------------------------------------- 110 (199) T cd04110 83 IVVYDVTNGESF-VNVKRWLQEIEQNCDD--------------------------------------------------- 110 (199) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999877997799-9999999999851256--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 8876230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) +|+++|.+|+|. +++.-+-..-.+.+|-++++..|.||+|...|++-+.+.|.-.++ T Consensus 111 -----------~~~iLVGNK~Dl-----------~~~r~v~~ee~~~~a~~~~~~f~EtSAktg~nV~e~F~~i~~~i~ 167 (199) T cd04110 111 -----------VCKVLVGNKNDD-----------PERKVVETEDAYKFAGQMGISLFETSAKENINVEEMFNCITELVL 167 (199) T ss_pred -----------CCEEEEEECCCC-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -----------736998403363-----------112265689999999966995999971589888899999999999 No 25 >cd04139 RalA_RalB RalA/RalB subfamily. The Ral (Ras-like) subfamily consists of the highly homologous RalA and RalB. Ral proteins are believed to play a crucial role in tumorigenesis, metastasis, endocytosis, and actin cytoskeleton dynamics. Despite their high sequence similarity (80% sequence identity), nonoverlapping and opposing functions have been assigned to RalA and RalBs in tumor migration. In human bladder and prostate cancer cells, RalB promotes migration while RalA inhibits it. A Ral-specific set of GEFs has been identified that are activated by Ras binding. This RalGEF activity is enhanced by Ras binding to another of its target proteins, phosphatidylinositol 3-kinase (PI3K). Ral effectors include RLIP76/RalBP1, a Rac/cdc42 GAP, and the exocyst (Sec6/8) complex, a heterooctomeric protein complex that is involved in tethering vesicles to specific sites on the plasma membrane prior to exocytosis. In rat kidney cells, RalB is required for functional assembly of the exo Probab=98.92 E-value=4.6e-09 Score=77.74 Aligned_columns=157 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+++...-+..|. -.+..+.+. ..+++|-..|...+..|.+.-+.--+ .+ T Consensus 3 ivliGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~-~~i~~~~~~--v~l~iwDt~Gqe~~~~l~~~~~~~a~----~~ 75 (164) T cd04139 3 VIVVGAGGVGKSALTLQFMYDEFVEDYEPTKADSYR-KKVVLDGED--VQLNILDTAGQEDYAAIRDNYHRSGE----GF 75 (164) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEE-EEEEECCCE--EEEEEEECCCCHHHHHHHHHHCCCCC----EE T ss_conf 899817985489999998718207654432232146-899885938--99998427887135788887525898----79 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+.++ +.+.+|..-+..+...-.+ T Consensus 76 ilvydit~~~Sf-~~i~~~~~~~~~~~~~~~i------------------------------------------------ 106 (164) T cd04139 76 LLVFSITDMESF-TATAEFREQILRVKDDDNV------------------------------------------------ 106 (164) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHHCCCCC------------------------------------------------ T ss_conf 999752885578-8999999999986179972------------------------------------------------ Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 8876230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) |+++|.+|+|. +++..+-.+..+.+|-++|+..|-||+|.+.|++-+...|.-+++ T Consensus 107 ------------p~ilvGNK~Dl-----------~~~r~v~~~e~~~~a~~~~~~~~E~SAk~g~ni~e~F~~l~~~i~ 162 (164) T cd04139 107 ------------PLLLVGNKCDL-----------EDKRQVSSEEAANLARQWGVPYVETSAKTRQNVEKAFYDLVREIR 162 (164) T ss_pred ------------EEEEECCCHHH-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ------------79997240132-----------231167489999999965995999971589887899999999996 No 26 >cd01861 Rab6 Rab6 subfamily. Rab6 is involved in microtubule-dependent transport pathways through the Golgi and from endosomes to the Golgi. Rab6A of mammals is implicated in retrograde transport through the Golgi stack, and is also required for a slow, COPI-independent, retrograde transport pathway from the Golgi to the endoplasmic reticulum (ER). This pathway may allow Golgi residents to be recycled through the ER for scrutiny by ER quality-control systems. Yeast Ypt6p, the homolog of the mammalian Rab6 GTPase, is not essential for cell viability. Ypt6p acts in endosome-to-Golgi, in intra-Golgi retrograde transport, and possibly also in Golgi-to-ER trafficking. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Probab=98.91 E-value=3.3e-09 Score=78.69 Aligned_columns=156 Identities=25% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+.+...-|.+|.--.+.-+++ .-.+.+|=..|...+..|.+.-+.--+ .+ T Consensus 3 I~~iG~~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~i~~~~~--~v~l~i~Dt~G~e~~~~l~~~~~~~~~----~~ 76 (161) T cd01861 3 LVFLGDQSVGKTSIITRFMYDTFDNQYQATIGIDFLSKTMYLEDK--TVRLQLWDTAGQERFRSLIPSYIRDSS----VA 76 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCE--EEEEEEECCCCCHHHHHHHHHHCCCCC----CE T ss_conf 899817985589999988638126655743433688889988793--999998517884257788898603888----17 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) |||-|++.+-++ +.+++|+.-+++.... T Consensus 77 ilvyd~t~~~Sf-~~~~~w~~~i~~~~~~--------------------------------------------------- 104 (161) T cd01861 77 VVVYDITNRQSF-DNTDKWIDDVRDERGN--------------------------------------------------- 104 (161) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999853987689-9999999888862399--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 887623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) .+|+++|++|+|. .++..+-.+-.+.++-++|+..+-||+|.+.|++-+.+-|...| T Consensus 105 ----------~~~iilVgNK~Dl-----------~~~~~v~~~~~~~~a~~~~~~~~E~Sak~~~nV~e~F~~ia~~l 161 (161) T cd01861 105 ----------DVIIVLVGNKTDL-----------SDKRQVSTEEGEKKAKELNAMFIETSAKAGHNVKELFRKIASAL 161 (161) T ss_pred ----------CCEEEEEECCCCH-----------HHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC T ss_conf ----------9789997155332-----------12136768899999996599399997148978789999999839 No 27 >cd04120 Rab12 Rab12 subfamily. Rab12 was first identified in canine cells, where it was localized to the Golgi complex. The specific function of Rab12 remains unknown, and inconsistent results about its cellular localization have been reported. More recent studies have identified Rab12 associated with post-Golgi vesicles, or with other small vesicle-like structures but not with the Golgi complex. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic Probab=98.91 E-value=5.1e-09 Score=77.44 Aligned_columns=157 Identities=29% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+.+...-|.+|..-.+.-+.+.. ++.+|=..|...+.+|.+.-..--. .+ T Consensus 3 IvliGd~~VGKTsli~rf~~~~F~~~y~~Tig~df~~k~i~i~g~~i--~lqIwDTaGqE~f~~l~~~y~r~a~----g~ 76 (202) T cd04120 3 VIIIGSRGVGKTSLMRRFTDDTFCEACKSGVGVDFKIKTVELRGKKI--RLQIWDTAGQERFNSITSAYYRSAK----GI 76 (202) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHHCCCC----EE T ss_conf 89980798428999999763811666565123578899999879189--9998756886035788777632898----79 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) |||-|.+.+.+|-. |++|+..++.+... T Consensus 77 ilVyDit~~~SF~~-l~~W~~~i~~~~~~--------------------------------------------------- 104 (202) T cd04120 77 ILVYDITKKETFDD-LPKWMKMIDKYASE--------------------------------------------------- 104 (202) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 99976698457899-99999999972499--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHHHHHC Q ss_conf 8876230058832799850741255554205774789999999999999971876888-326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~HrLy 305 (523) .+|+++|.+|+|+ +.+..+-.+--+.||-++++..+| ||+|.+.|++-+..-|.-+++ T Consensus 105 ----------~~~iiLVGNK~DL-----------~~~R~Vs~~e~~~~A~~~~~~~f~EtSAk~~~NV~e~F~~l~~~i~ 163 (202) T cd04120 105 ----------DAELLLVGNKLDC-----------ETDREISRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDIL 163 (202) T ss_pred ----------CEEEEEEECCCCH-----------HHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ----------3489997122212-----------1020236799999999708970899851489888899999999999 No 28 >cd04127 Rab27A Rab27a subfamily. The Rab27a subfamily consists of Rab27a and its highly homologous isoform, Rab27b. Unlike most Rab proteins whose functions remain poorly defined, Rab27a has many known functions. Rab27a has multiple effector proteins, and depending on which effector it binds, Rab27a has different functions as well as tissue distribution and/or cellular localization. Putative functions have been assigned to Rab27a when associated with the effector proteins Slp1, Slp2, Slp3, Slp4, Slp5, DmSlp, rabphilin, Dm/Ce-rabphilin, Slac2-a, Slac2-b, Slac2-c, Noc2, JFC1, and Munc13-4. Rab27a has been associated with several human diseases, including hemophagocytic syndrome (Griscelli syndrome or GS), Hermansky-Pudlak syndrome, and choroidermia. In the case of GS, a rare, autosomal recessive disease, a Rab27a mutation is directly responsible for the disorder. When Rab27a is localized to the secretory granules of pancreatic beta cells, it is believed to mediate glucose-stimulated Probab=98.90 E-value=5.3e-09 Score=77.36 Aligned_columns=160 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHH--------HHCCEEEECCCCCCCCCCCCCCCC Q ss_conf 88973699767899999742---0146888652145640450000432--------524636865862432455567870 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQ--------TRCNVWILDGDLYHKGLLKFSLDA 138 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~--------ar~~vWiLdg~~~~~~LLK~aLt~ 138 (523) |+++|+.++|||+|+.++.. .+.+...-|+++..-.+.-+.++.. -.+.+|=..|...+.+|.+....- T Consensus 7 ivviGd~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~i~~~~~~~~~~~~~~~~v~l~iwDtaGqe~~~~l~~~~~~~ 86 (180) T cd04127 7 FLALGDSGVGKTSFLYQYTDNKFNPKFITTVGIDFREKRVVYNSSGPGGTLGRGQRIHLQLWDTAGQERFRSLTTAFFRD 86 (180) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCC T ss_conf 99980698438999888763832776354011135577999712554332457727999997247762145676886049 Q ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC Q ss_conf 02666455655401013689999999999999999732789889999999999999985045556666553445676667 Q Ver_Hs_NP_0572 139 VSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQED 218 (523) Q Consensus 139 ~si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~ 218 (523) -+ .++||-|.+.+.++-. ++.|+..++.+... T Consensus 87 a~----~~ilvydit~~~Sf~~-~~~w~~~i~~~~~~------------------------------------------- 118 (180) T cd04127 87 AM----GFLLIFDLTNEQSFLN-VRNWMSQLQTHAYC------------------------------------------- 118 (180) T ss_pred CC----EEEEEEECCCHHHHHH-HHHHHHHHHHHCCC------------------------------------------- T ss_conf 98----8999974689668899-99999999861367------------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHH Q ss_conf 76534478887623005883279985074125555420577478999999999999997187688832663678999999 Q Ver_Hs_NP_0572 219 KDDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYK 298 (523) Q Consensus 219 ~d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLyk 298 (523) -.+|+++|++|+|. +++..+-..-.+.||-.++...|.||+|.+.|++-+.. T Consensus 119 -----------------~~~~ivlVgNK~Dl-----------~~~r~Vs~~e~~~~a~~~~~~~~e~SAk~~~nV~e~F~ 170 (180) T cd04127 119 -----------------ENPDIVLCGNKADL-----------EDQRQVSEEQAKALADKYGIPYFETSAATGTNVEKAVE 170 (180) T ss_pred -----------------CCCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf -----------------87507887202355-----------21122487899999996599599997147988789999 Q ss_pred HHHHHHC Q ss_conf 9998760 Q Ver_Hs_NP_0572 299 YIVQKLY 305 (523) Q Consensus 299 Yl~HrLy 305 (523) +|.-+++ T Consensus 171 ~l~~~i~ 177 (180) T cd04127 171 RLLDLVM 177 (180) T ss_pred HHHHHHH T ss_conf 9999999 No 29 >cd04114 Rab30 Rab30 subfamily. Rab30 appears to be associated with the Golgi stack. It is expressed in a wide variety of tissue types and in humans maps to chromosome 11. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. Probab=98.89 E-value=6e-09 Score=77.03 Aligned_columns=158 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|+.++|||+|+.|+..-+-..+-.. .+-.|....-.-.+..-.+.+|=..|...+..|.+.-+.--+ .++| T Consensus 10 ivliGd~~VGKTsli~rf~~~~f~~~~~~Ti~~~~~~k~~~~~~~~v~l~iwDtaG~e~~~~~~~~~~~~a~----~~ii 85 (169) T cd04114 10 IVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEIKGEKIKLQIWDTAGQERFRSITQSYYRSAN----ALIL 85 (169) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHCCCC----EEEE T ss_conf 999826984489999998628678543311221147889988895999999865898024677687604888----3899 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|.+.+=++ +.|.+|++-++++... T Consensus 86 vydit~~~Sf-~~i~~w~~~i~~~~~~----------------------------------------------------- 111 (169) T cd04114 86 TYDITCEESF-RCLPEWLREIEQYANN----------------------------------------------------- 111 (169) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHHCC----------------------------------------------------- T ss_conf 9655984688-9999999999874069----------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 7623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) .+|+++|++|+|.. ++..+-.+-.+.+|-++|...|-||+|.+.|++.+..+|.-+| T Consensus 112 --------~~~iilVGNK~Dl~-----------~~r~v~~~~~~~~a~~~~~~~~e~SAktg~nV~~~F~~la~~i 168 (169) T cd04114 112 --------KVITILVGNKIDLA-----------ERREVSQQRAEEFSDAQDMYYLETSAKESDNVEKLFLDLACRL 168 (169) T ss_pred --------CCEEEEEECCCCCC-----------CCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH T ss_conf --------94189981143211-----------0236587899999996498399997037988889999999982 No 30 >cd01864 Rab19 Rab19 subfamily. Rab19 proteins are associated with Golgi stacks. Similarity analysis indicated that Rab41 is closely related to Rab19. However, the function of these Rabs is not yet chracterized. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. Probab=98.89 E-value=4.7e-09 Score=77.70 Aligned_columns=156 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+.+...-|.+|..-.+.-+ +..-.+.+|-..|...+..|.+.-..--+ .+ T Consensus 6 ivivGd~~vGKTsli~rf~~~~F~~~~~~tig~~~~~k~i~~~--~~~v~l~iwDt~G~e~~~~l~~~~~~~~~----~~ 79 (165) T cd01864 6 IILIGDSNVGKTCVVQRFKSGTFSERQGNTIGVDFTMKTLEIE--GKRVKLQIWDTAGQERFRTITQSYYRSAN----GA 79 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEC--CEEEEEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 9998079944899999876282077667711257789999988--95899999754887013577686426998----79 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+-++-. |++|+.-++++..+ T Consensus 80 ilvydit~~~Sf~~-l~~w~~~i~~~~~~--------------------------------------------------- 107 (165) T cd01864 80 IIAYDITRRSSFES-VPHWIEEVEKYGAS--------------------------------------------------- 107 (165) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHCCCC--------------------------------------------------- T ss_conf 99987599779999-99988889851698--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEE-EEECCCCHHHHHHHHHHHHHHH Q ss_conf 88762300588327998507412555542057747899999999999999718768-8832663678999999999876 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAAL-IYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaL-iYTS~ke~knl~LLykYl~HrL 304 (523) .+|+++|.+|+|. .++..+-..-.+.+|-++|+-- |-||+|.+.|++-+..+|.+.| T Consensus 108 ----------~~~ivlVGNK~Dl-----------~~~r~V~~~~~~~~a~~~~~~~~~E~SAk~~~nv~e~F~~la~~i 165 (165) T cd01864 108 ----------NVVLLLIGNKCDL-----------EEQREVLFEEACTLAEKNGMLAVLETSAKESQNVEEAFLLMATEL 165 (165) T ss_pred ----------CCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHC T ss_conf ----------9579997242110-----------003554578999999964994899974048989889999999829 No 31 >cd04140 ARHI_like ARHI subfamily. ARHI (A Ras homolog member I) is a member of the Ras family with several unique structural and functional properties. ARHI is expressed in normal human ovarian and breast tissue, but its expression is decreased or eliminated in breast and ovarian cancer. ARHI contains an N-terminal extension of 34 residues (human) that is required to retain its tumor suppressive activity. Unlike most other Ras family members, ARHI is maintained in the constitutively active (GTP-bound) state in resting cells and has modest GTPase activity. ARHI inhibits STAT3 (signal transducers and activators of transcription 3), a latent transcription factor whose abnormal activation plays a critical role in oncogenesis. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Due to Probab=98.89 E-value=9.8e-09 Score=75.61 Aligned_columns=159 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|+.++|||+|+.++..-+-...-.. ++-.|-.+...+... -.+.+|-..|...+..|.+.-+.--+ .+|| T Consensus 4 IvliGd~~VGKTsli~r~~~~~F~~~y~~ti~~~~~~~i~~~~~~-~~l~i~Dt~G~e~~~~l~~~~~~~a~----~~il 78 (165) T cd04140 4 VVVFGAGGVGKSSLVLRFVKGTFRESYIPTIEDTYRQVISCSKNI-CTLQITDTTGSHQFPAMQRLSISKGH----AFIL 78 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECEEEEEEEECCCE-EEEEEECCCCCCCHHHHHHHHHCCCC----EEEE T ss_conf 899807996589999887628206654542001157788636948-99997037763102356688621898----5899 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHH-HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 5401013689999999999999999-732789889999999999999985045556666553445676667765344788 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHV-DKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPL 227 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi-~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPL 227 (523) |-|.+.+.+| +.++.|...+.+.- +... T Consensus 79 vydit~~~Sf-~~i~~~~~~i~~~~~~~~~-------------------------------------------------- 107 (165) T cd04140 79 VYSVTSKQSL-EELKPIYELICEIKGNNIE-------------------------------------------------- 107 (165) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHHCCCCC-------------------------------------------------- T ss_conf 9875997788-9999999999986224889-------------------------------------------------- Q ss_pred CCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 87623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 228 GADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 228 geg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) .+|+++|.+|+| |+.++.-..|+ .+.+|-++++..|.||+|.+.|++.+.+.|+..+ T Consensus 108 ---------~ipiilvGNK~D----l~~~r~V~~~e-------~~~~a~~~~~~~~E~SAk~~~nv~~~F~~l~~l~ 164 (165) T cd04140 108 ---------KIPIMLVGNKCD----ESHKREVSSNE-------GAACATEWNCAFMETSAKTNHNVQELFQELLNLE 164 (165) T ss_pred ---------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC T ss_conf ---------857999503114----01046689899-------9999995699589997148988789999999851 No 32 >cd00157 Rho Rho (Ras homology) family. Members of the Rho family include RhoA, Cdc42, Rac, Rnd, Wrch1, RhoBTB, and Rop. There are 22 human Rho family members identified currently. These proteins are all involved in the reorganization of the actin cytoskeleton in response to external stimuli. They also have roles in cell transformation by Ras in cytokinesis, in focal adhesion formation and in the stimulation of stress-activated kinase. These various functions are controlled through distinct effector proteins and mediated through a GTP-binding/GTPase cycle involving three classes of regulating proteins: GAPs (GTPase-activating proteins), GEFs (guanine nucleotide exchange factors), and GDIs (guanine nucleotide dissociation inhibitors). Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho protein Probab=98.89 E-value=2.8e-09 Score=79.19 Aligned_columns=167 Identities=16% Q ss_pred EEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 58897369976789999974201468886521456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 69 NVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 69 nILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) .|+++|+.++|||+|+.++..-+-...-..--.-.+...-...+..-.+.+|=..|...+..|.+....--+. ++| T Consensus 2 Ki~liGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~~i~~~~~~~~l~iwDt~G~e~~~~l~~~~~~~a~~----~il 77 (171) T cd00157 2 KIVVVGDGAVGKTCLLISYTTGKFPTEYVPTVFDNYSATVTVDGKQVNLGLWDTAGQEEYDRLRPLSYPNTDV----FLI 77 (171) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHCCCCE----EEE T ss_conf 7899807995489999998638316653432652145578755679999996067743467898987328985----899 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|.+.+.++-+-+++|+..++.+... T Consensus 78 vydit~~~Sf~~~~~~w~~~i~~~~~~----------------------------------------------------- 104 (171) T cd00157 78 CFSVDSPSSFENVKTKWIPEIRHYCPN----------------------------------------------------- 104 (171) T ss_pred EEECCCHHHHHHHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 971688658999999989999984689----------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHH Q ss_conf 76230058832799850741255554205774789999999999999971876888-32663678999999999 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYKYIV 301 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~ 301 (523) +|+++|.+|+|..+.=+......+.+.-+-.+-.+.+|-++|+..+| ||+|...|++-+..-|. T Consensus 105 ---------~piilVgnK~DL~~~~~~~~~~~~~~r~Vs~~e~~~~a~~~~~~~f~EtSAktg~nV~e~F~~l~ 169 (171) T cd00157 105 ---------VPIILVGTKIDLRDDENTLKKLEKGKEPITPEEGEKLAKEIGAIGYMECSALTQEGVKEVFEEAI 169 (171) T ss_pred ---------CEEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH T ss_conf ---------56999853744212112232210135778989999999973995278875048988789999996 No 33 >cd04125 RabA_like RabA-like subfamily. RabA was first identified in D. discoideum, where its expression levels were compared to other Rabs in growing and developing cells. The RabA mRNA levels were below the level of detection by Northern blot analysis, suggesting a very low level of expression. The function of RabA remains unknown. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=98.89 E-value=7.2e-09 Score=76.49 Aligned_columns=157 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.|+.. .+.+...-|.+|..-.+.-+++ .-.+.+|=..|...+..|.+.-..--+ .+ T Consensus 3 IvviGd~~VGKTsli~r~~~~~f~~~~~~Tig~d~~~k~i~~~~~--~v~l~iwDtaGqe~~~~l~~~~~~~a~----~~ 76 (188) T cd04125 3 VVIIGDYGVGKSSLLKRFTEDEFSESTKSTIGVDFKIKTVYIENK--IIKLQIWDTNGQERFRSLNNSYYRGAH----GY 76 (188) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCE--EEEEEEEECCCCCHHHHHHHHHHCCCC----EE T ss_conf 899826995489999987628017764673021257889998684--999998756998202567687630898----59 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) |||-|.+.+.+|-. ++.|+.-++.+... T Consensus 77 ilvyDit~~~Sf~~-i~~w~~~i~~~~~~--------------------------------------------------- 104 (188) T cd04125 77 LLVYDVTDQESFEN-LKFWINEINRYARE--------------------------------------------------- 104 (188) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 99986699789999-99999999861699--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 8876230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) .+|+++|++|+|. .++..+-..-.+.||-++|+..|-||++.+.|++-+..+|.-.++ T Consensus 105 ----------~~~~ilvgNK~DL-----------~~~r~V~~~~~~~~a~~~~~~~fEtSAktg~nV~e~F~~l~~~il 162 (188) T cd04125 105 ----------NVIKVIVANKSDL-----------VNNKVVDSNIAKSFCDSLNIPFFETSAKQSINVEEAFILLVKLII 162 (188) T ss_pred ----------CCEEEEEEECCCC-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ----------9689998513523-----------012336999999999856992999962589888899999999999 No 34 >cd04124 RabL2 RabL2 subfamily. RabL2 (Rab-like2) subfamily. RabL2s are novel Rab proteins identified recently which display features that are distinct from other Rabs, and have been termed Rab-like. RabL2 contains RabL2a and RabL2b, two very similar Rab proteins that share 98% sequence identity in humans. RabL2b maps to the subtelomeric region of chromosome 22q13.3 and RabL2a maps to 2q13, a region that suggests it is also a subtelomeric gene. Both genes are believed to be expressed ubiquitously, suggesting that RabL2s are the first example of duplicated genes in human proximal subtelomeric regions that are both expressed actively. Like other Rab-like proteins, RabL2s lack a prenylation site at the C-terminus. The specific functions of RabL2a and RabL2b remain unknown. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-b Probab=98.89 E-value=1.2e-08 Score=75.11 Aligned_columns=154 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|+.++|||+|+.|+..-+-..+-.. .+..++...-.-.+..-.+.+|=..|...+.++.+....--+ .++| T Consensus 3 iiliGd~~VGKTsli~r~~~~~f~~~~~~t~~~~~~~k~~~~~~~~v~l~iwDt~G~e~~~~~~~~~~~~a~----~~il 78 (161) T cd04124 3 IILLGDSAVGKSKLVERFLMDGYEPQQLSTYALTLYKHNAKFEGKTILVDFWDTAGQERFQTMHASYYHKAH----ACIL 78 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCCCC----EEEE T ss_conf 899806994488988786538637662353256789999999886999999745784110356674302478----5899 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|.+.+.++ +.|.+|+.-++++-.. T Consensus 79 vfDit~~~Sf-~~l~~W~~~i~~~~~~----------------------------------------------------- 104 (161) T cd04124 79 VFDVTRKITY-KNLSKWYEELREYRPE----------------------------------------------------- 104 (161) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 9866996688-9999999999984699----------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 7623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) +|+++|++|+|. +.. +.+--+.++-+++...|+||+|.+.|++.+.+-+.-.. T Consensus 105 ---------~p~ilVGNK~Dl-----------~~~---~~~~~~~~a~~~~~~~fetSAk~g~nV~e~F~~~~~~~ 157 (161) T cd04124 105 ---------IPCIVVANKIDL-----------DPS---VTQKKFNFAEKHNLPLYYVSAADGTNVVKLFQDAIKLA 157 (161) T ss_pred ---------CEEEEEECCCCC-----------CHH---HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH T ss_conf ---------379998237656-----------435---68999999996599199997268988789999999999 No 35 >cd01860 Rab5_related Rab5-related subfamily. This subfamily includes Rab5 and Rab22 of mammals, Ypt51/Ypt52/Ypt53 of yeast, and RabF of plants. The members of this subfamily are involved in endocytosis and endocytic-sorting pathways. In mammals, Rab5 GTPases localize to early endosomes and regulate fusion of clathrin-coated vesicles to early endosomes and fusion between early endosomes. In yeast, Ypt51p family members similarly regulate membrane trafficking through prevacuolar compartments. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence mo Probab=98.88 E-value=3.9e-09 Score=78.25 Aligned_columns=158 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|+.++|||+|+.++..-+-..+-.. ++..|....=.-.+.+-.+.+|-..|...+..|.+....--+ .++| T Consensus 4 i~iiG~~gvGKTsli~r~~~~~f~~~~~pTig~~~~~k~i~~~~~~v~l~i~Dt~G~e~~~~l~~~~~~~a~----~~il 79 (163) T cd01860 4 LVLLGDSSVGKSSLVLRFVKNEFSENQESTIGAAFLTQTVNLDDTTVKFEIWDTAGQERYRSLAPMYYRGAA----AAIV 79 (163) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCEEEEEEEECCCCCHHHHHHHHHHHCCCC----EEEE T ss_conf 999816996589999988628337553510132256889988887999997048983124566676513888----4999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|++.+=++-. +.+|+.-++.+... T Consensus 80 vydit~~~Sf~~-i~~w~~~i~~~~~~----------------------------------------------------- 105 (163) T cd01860 80 VYDITSEESFEK-AKSWVKELQRNASP----------------------------------------------------- 105 (163) T ss_pred EEECCCHHHHHH-HHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 986599789999-99988765530699----------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 7623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) .+|+++|.+|+|. +++..+-.+-.+.+|-++++..+.||++.+.|++-+...|.-++ T Consensus 106 --------~~~iilVgNK~Dl-----------~~~r~v~~~e~~~~a~~~~~~~~e~SAk~~~nI~~~F~~l~~~i 162 (163) T cd01860 106 --------NIIIALVGNKADL-----------ESKRQVSTEEAQEYADENGLLFFETSAKTGENVNELFTEIAKKL 162 (163) T ss_pred --------CCEEEEEECCHHH-----------HHCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC T ss_conf --------9589998322105-----------43058878999999996599299997148988889999999857 No 36 >cd01867 Rab8_Rab10_Rab13_like Rab8/Sec4/Ypt2. Rab8/Sec4/Ypt2 are known or suspected to be involved in post-Golgi transport to the plasma membrane. It is likely that these Rabs have functions that are specific to the mammalian lineage and have no orthologs in plants. Rab8 modulates polarized membrane transport through reorganization of actin and microtubules, induces the formation of new surface extensions, and has an important role in directed membrane transport to cell surfaces. The Ypt2 gene of the fission yeast Schizosaccharomyces pombe encodes a member of the Ypt/Rab family of small GTP-binding proteins, related in sequence to Sec4p of Saccharomyces cerevisiae but closer to mammalian Rab8. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhi Probab=98.88 E-value=7.5e-09 Score=76.37 Aligned_columns=157 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+.+...-|.+|.-..|.-+++.. ++.+|=..|...+..+.+....--+ .+ T Consensus 6 i~liGd~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~v~~~~~~v--~l~iwDt~G~e~~~~~~~~~~~~a~----~~ 79 (167) T cd01867 6 LLLIGDSGVGKSCLLLRFSEDSFNPSFISTIGIDFKIRTIELDGKKI--KLQIWDTAGQERFRTITTAYYRGAM----GI 79 (167) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 99982698438999988763810765564121256788999889499--9999866898002345375436998----89 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|++.+ .=.+.++.|+.-++.|... T Consensus 80 iivfDit~~-~Sf~~i~~w~~~i~~~~~~--------------------------------------------------- 107 (167) T cd01867 80 ILVYDITDE-KSFENIRNWMRNIEEHASE--------------------------------------------------- 107 (167) T ss_pred EEEEECCCH-HHHHHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999856984-6789999999999852699--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 8876230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) .+|+++|.+|+|. ++...+-.+-.+.+|-++|+..+.||+|.+.|++-+...|.-.+. T Consensus 108 ----------~~~~ilVGNK~DL-----------~~~r~v~~~~~~~~a~~~~~~~~e~SAk~~~nv~~~F~~l~~~i~ 165 (167) T cd01867 108 ----------DVERMLVGNKCDM-----------EEKRVVSKEEGEALADEYGIKFLETSAKANINVEEAFFTLAKDIK 165 (167) T ss_pred ----------CCEEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHH T ss_conf ----------9389999404675-----------222466989999999964995999970489787899999999997 No 37 >cd01862 Rab7 Rab7 subfamily. Rab7 is a small Rab GTPase that regulates vesicular traffic from early to late endosomal stages of the endocytic pathway. The yeast Ypt7 and mammalian Rab7 are both involved in transport to the vacuole/lysosome, whereas Ypt7 is also required for homotypic vacuole fusion. Mammalian Rab7 is an essential participant in the autophagic pathway for sequestration and targeting of cytoplasmic components to the lytic compartment. Mammalian Rab7 is also proposed to function as a tumor suppressor. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C- Probab=98.86 E-value=7.4e-09 Score=76.41 Aligned_columns=159 Identities=30% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+.+...-|.+|....+.-+++ ...+.+|=..|...+..|.+.-..--+ .+ T Consensus 3 ivliGd~~vGKTsli~r~~~~~f~~~y~~Tig~~~~~k~i~~~~~--~~~l~i~Dt~G~e~~~~l~~~~~~~a~----~~ 76 (172) T cd01862 3 VIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVTVDDK--LVTLQIWDTAGQERFQSLGVAFYRGAD----CC 76 (172) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCE--EEEEEEEECCCCCCHHHHHHHHHCCCC----EE T ss_conf 899817984489999998628106653552001577889999887--999999866899300357788723896----79 Q ss_pred HHHHHHHHHHHHHHHHHHHHH--HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 655401013689999999999--999999732789889999999999999985045556666553445676667765344 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWAS--VVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVV 224 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~--vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~ 224 (523) +||-|.+.+.++-. +.+|.. +.+.+..... T Consensus 77 ilvydit~~~Sf~~-i~~w~~e~~~~~~~~~~~----------------------------------------------- 108 (172) T cd01862 77 VLVYDVTNPKSFES-LDSWRDEFLIQASPSDPE----------------------------------------------- 108 (172) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCCCCCC----------------------------------------------- T ss_conf 99985698557899-999999999863877788----------------------------------------------- Q ss_pred CCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC-CEEEEECCCCHHHHHHHHHHHHHH Q ss_conf 7888762300588327998507412555542057747899999999999999718-768883266367899999999987 Q Ver_Hs_NP_0572 225 VPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYG-AALIYTSVKENKNIDLVYKYIVQK 303 (523) Q Consensus 225 lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YG-AaLiYTS~ke~knl~LLykYl~Hr 303 (523) .+|+++|++|+|. +++..+-..-.+.||-.++ +..+.||++.+.|++.+...|.-+ T Consensus 109 ------------~iP~ilVGnK~Dl-----------~~~r~v~~~e~~~~a~~~~~~~~~e~SAk~~~nV~e~F~~l~~~ 165 (172) T cd01862 109 ------------NFPFVVLGNKIDL-----------EEKRQVSTKKAQQWCQSNGNIPYFETSAKEAINVEQAFETIARK 165 (172) T ss_pred ------------CCEEEEECCCCCH-----------HHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHH T ss_conf ------------6079997141000-----------12115317899999997079607998604897878999999999 Q ss_pred HC Q ss_conf 60 Q Ver_Hs_NP_0572 304 LY 305 (523) Q Consensus 304 Ly 305 (523) ++ T Consensus 166 ~~ 167 (172) T cd01862 166 AL 167 (172) T ss_pred HH T ss_conf 99 No 38 >cd04132 Rho4_like Rho4-like subfamily. Rho4 is a GTPase that controls septum degradation by regulating secretion of Eng1 or Agn1 during cytokinesis. Rho4 also plays a role in cell morphogenesis. Rho4 regulates septation and cell morphology by controlling the actin cytoskeleton and cytoplasmic microtubules. The localization of Rho4 is modulated by Rdi1, which may function as a GDI, and by Rga9, which is believed to function as a GAP. In S. pombe, both Rho4 deletion and Rho4 overexpression result in a defective cell wall, suggesting a role for Rho4 in maintaining cell wall integrity. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Probab=98.86 E-value=2.1e-08 Score=73.47 Aligned_columns=165 Identities=20% Q ss_pred CEEEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 6588973699767899999742014688865-214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 68 KNVLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 68 KnILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |-|+++|+.++|||+|+.++..-+-...-.+ ++-.|..-..-.....-.+.+|=..|...+..|.+.-..--+ .+ T Consensus 1 ~KVvliGd~~VGKTsli~r~~~~~F~~~~~~Ti~~~~~~~~~~~~~~~v~l~iwDtaGqe~f~~l~~~~~~~a~----~~ 76 (187) T cd04132 1 KKIVVVGDGGCGKTCLLIVYSQGKFPEEYVPTVFENYVTNIQGPNGKIIELALWDTAGQEEYDRLRPLSYPDVD----VL 76 (187) T ss_pred CEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHCCCC----EE T ss_conf 96899817983289999887618226764651576789999973881899986148775245778887724897----58 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.|.+|-.-...|+..++ +|.+ T Consensus 77 ilvyDit~~~Sf~~~~~~W~~~i~-------------------------~~~~--------------------------- 104 (187) T cd04132 77 LICYAVDNPTSLDNVEDKWFPEVN-------------------------HFCP--------------------------- 104 (187) T ss_pred EEEEECCCHHHHHHHHHHHHHHHH-------------------------HHCC--------------------------- T ss_conf 999865997899999987789999-------------------------8458--------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHHHHHC Q ss_conf 8876230058832799850741255554205774789999999999999971876888-326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~HrLy 305 (523) .+|+++|.+|+|..+.-+..+.-..|+- +.+|-+.|+..+| ||++...|++-+..+|.-.++ T Consensus 105 ----------~~piilVGNK~DL~~~~~~~r~V~~~e~-------~~~a~~~~~~~y~EtSAk~g~nV~e~F~~l~~~~l 167 (187) T cd04132 105 ----------GTPIMLVGLKTDLRKDKNLDRKVTPAQA-------ESVAKKQGAFAYLECSAKTMENVEEVFDTAIEEAL 167 (187) T ss_pred ----------CCEEEEEECCCCCHHHHCCCCCCCHHHH-------HHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH T ss_conf ----------9779998416751223111367898899-------99999738932689861278887899999999998 No 39 >cd04107 Rab32_Rab38 Rab38/Rab32 subfamily. Rab32 and Rab38 are members of the Rab family of small GTPases. Human Rab32 was first identified in platelets but it is expressed in a variety of cell types, where it functions as an A-kinase anchoring protein (AKAP). Rab38 has been shown to be melanocyte-specific. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=98.84 E-value=1.7e-08 Score=74.05 Aligned_columns=162 Identities=29% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.|+-. .+.+...-|.+|..-.+.- |....-.+.+|=..|...+.+|.+.-..--+ .+ T Consensus 3 IvliGd~~VGKTsli~r~~~~~F~~~~~~Tig~d~~~k~i~~-~~~~~v~l~iwDtaGqe~f~~l~~~y~r~a~----~~ 77 (201) T cd04107 3 VLVIGDLGVGKTSIIKRYVHGIFSQHYKATIGVDFALKVIEW-DPNTVVRLQLWDIAGQERFGGMTRVYYRGAV----GA 77 (201) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEE-CCCEEEEEEEECCCCCHHHHHHHHHHCCCCC----EE T ss_conf 899816995489999997718006765650344677889987-6976899986227884245566565427987----69 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+ .=.+.+..|+.-+...+ T Consensus 78 ilvyDit~~-~SF~~i~~W~~~i~~~~----------------------------------------------------- 103 (201) T cd04107 78 IIVFDVTRP-STFEAVLKWKADLDSKV----------------------------------------------------- 103 (201) T ss_pred EEEEECCCH-HHHHHHHHHHHHHHHHH----------------------------------------------------- T ss_conf 999873897-78999999999999874----------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC-CEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 88762300588327998507412555542057747899999999999999718-76888326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYG-AALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YG-AaLiYTS~ke~knl~LLykYl~HrLy 305 (523) ....+--+|+++|.+|+|. +++..+-......||-++| ...|.||+|...|++-+...|.-++. T Consensus 104 ----~~~~~~~ipiilVGNK~DL-----------~~~~~v~~~e~~~~a~~~~~~~~fEtSAktg~nV~e~F~~l~~~i~ 168 (201) T cd04107 104 ----TLPNGEPIPCLLLANKCDL-----------KKRLAKDGEQMDQFCKENGFIGWFETSAKEGINIEEAMRFLVKNIL 168 (201) T ss_pred ----HCCCCCCCEEEEEECCCCC-----------HHHCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ----0368997289997058873-----------0004479899999999639982688750489787899999999999 No 40 >cd04117 Rab15 Rab15 subfamily. Rab15 colocalizes with the transferrin receptor in early endosome compartments, but not with late endosomal markers. It codistributes with Rab4 and Rab5 on early/sorting endosomes, and with Rab11 on pericentriolar recycling endosomes. It is believed to function as an inhibitory GTPase that regulates distinct steps in early endocytic trafficking. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to Probab=98.83 E-value=2.3e-08 Score=73.19 Aligned_columns=156 Identities=27% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.|+.. .+.+...-|.+|..-.+.-++. ...+.+|=..|..-+..|.+....--+ .+ T Consensus 3 IiliGd~~VGKTsli~rf~~~~F~~~~~~Tig~~~~~k~i~~~~~--~i~l~iwDtaG~e~~~~l~~~~~~~a~----~~ 76 (161) T cd04117 3 LLLIGDSGVGKTCLLCRFTDNEFHSSHISTIGVDFKMKTIEVDGI--KVRIQIWDTAGQERYQTITKQYYRRAQ----GI 76 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCE--EEEEEEEECCCCHHHHHHHHHHCCCCC----EE T ss_conf 899826984489999987548217543442211146789989896--999998746987235667686446998----89 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+-++ +.+..|+.-++++-.. T Consensus 77 ilvydit~~~Sf-~~i~~w~~~i~~~~~~--------------------------------------------------- 104 (161) T cd04117 77 FLVYDISSERSY-QHIMKWVSDVDEYAPE--------------------------------------------------- 104 (161) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999865997899-9999999999972579--------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 887623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) .+|+++|.+|+|. +++..+-..-.+.+|-++|...+.||+|.+.|++-+...|.-.+ T Consensus 105 ----------~~~~ilVgnK~Dl-----------~~~r~v~~~e~~~~a~~~~~~~~E~SAk~~~nV~e~F~~la~li 161 (161) T cd04117 105 ----------GVQKILIGNKADE-----------EQKRQVGDEQGNKLAKEYGMDFFETSACTNSNIKESFTRLTELV 161 (161) T ss_pred ----------CCEEEEEECCCCH-----------HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC T ss_conf ----------9469998115780-----------23111468999999996599699997158988789999999829 No 41 >smart00174 RHO Rho (Ras homology) subfamily of Ras-like small GTPases; Members of this subfamily of Ras-like small GTPases include Cdc42 and Rac, as well as Rho isoforms. Probab=98.83 E-value=9.2e-09 Score=75.79 Aligned_columns=172 Identities=15% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |++||+.++|||+|+.++..-+=...-...-...+...-...+..-.+.+|=..|...+..|.+....--+ .+||| T Consensus 1 ivliGd~~VGKTsli~rf~~~~f~~~~~pTi~~~~~~~i~~~~~~v~l~iwDtaGqe~~~~l~~~~y~~a~----~~ilv 76 (174) T smart00174 1 LVVVGDGAVGKTCLLISYTTNAFPEDYVPTVFENYSADVEVDGKPVELGLWDTAGQEDYDRLRPLSYPDTD----VFLIC 76 (174) T ss_pred CEEECCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEECCCCCCCHHHHHHHHHHCCCC----EEEEE T ss_conf 67871598338999999861822666255154324675557786799986466666223566687643883----68999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+.+|-.=...|+.-++.+. T Consensus 77 ydit~~~Sf~~l~~~W~~~i~~~~-------------------------------------------------------- 100 (174) T smart00174 77 FSVDSPASFENVKEKWYPEVKHFC-------------------------------------------------------- 100 (174) T ss_pred EECCCHHHHHHHHHHHHHHHHHHC-------------------------------------------------------- T ss_conf 863886578999998899999847-------------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHH-HHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHHHHHCCC Q ss_conf 62300588327998507412555542057747899999-99999999971876888-32663678999999999876065 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFF-QSHIRKFCLRYGAALIY-TSVKENKNIDLVYKYIVQKLYGF 307 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfI-qq~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~HrLygf 307 (523) -.+|+++|.+|+|..+.-+.-....+++...| .+..+.+|-++|+-.+| ||+|...|++-+...+.-..... T Consensus 101 ------~~~piiLVGnK~DL~~~~~~~~~~~~~~~~~vs~~e~~~~a~~~~~~~y~EtSAktg~nV~e~F~~l~r~~l~k 174 (174) T smart00174 101 ------PNVPIILVGTKLDLRNDEDTLEELSKKKQEPVTYEQGEALAKRIGAVKYIECSALTQEGVREVFEEAIRAALNK 174 (174) T ss_pred ------CCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC T ss_conf ------89669997156563201345555431013568888999999971894168875048878789999999998529 No 42 >smart00175 RAB Rab subfamily of small GTPases; Rab GTPases are implicated in vesicle trafficking. Probab=98.82 E-value=1.5e-08 Score=74.39 Aligned_columns=159 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|+.++|||+|+.++..-+-...-.. ++..|....=.-.+..-.+.+|-..|...+..|.+.-+.--+ .++| T Consensus 3 iviiG~~~vGKTsii~~~~~~~f~~~~~~Ti~~~~~~k~v~~~~~~~~l~i~Dt~g~e~~~~~~~~~~~~~d----~~ii 78 (164) T smart00175 3 IILIGDSGVGKSSLLSRFTDGKFSEDSKSTIGVDFKTKTIEVDGKRVKLQIWDTAGQERFRSITSSYYRGAV----GALL 78 (164) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHCCCC----EEEE T ss_conf 899826996489999998628106655650223677899999896999998646987146777787504897----6999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|.+.+.++ +.+++|+..++.|. T Consensus 79 vfdi~~~~Sf-~~i~~w~~~i~~~~------------------------------------------------------- 102 (164) T smart00175 79 VYDITNRDSF-ENLENWLKELREYA------------------------------------------------------- 102 (164) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHC------------------------------------------------------- T ss_conf 9327987799-99999999999726------------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 76230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) +-.+|+++|++|+|. .+...+-.+-.+.+|-+++...+-||+|.+.|++-+...|...+. T Consensus 103 ------~~~~piilvgNK~Dl-----------~~~~~i~~~e~~~~a~~~~~~y~E~Sak~~~~i~e~F~~l~~~i~ 162 (164) T smart00175 103 ------DPNVVIMLVGNKSDL-----------EEQRQVSTEEAQKFAEEHGLLFIETSAKTNTNVEEAFEELAKEIL 162 (164) T ss_pred ------CCCCEEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ------999589998511022-----------000258989999999964982999970479887899999999997 No 43 >cd04136 Rap_like Rap-like subfamily. The Rap subfamily consists of the Rap1, Rap2, and RSR1. Rap subfamily proteins perform different cellular functions, depending on the isoform and its subcellular localization. For example, in rat salivary gland, neutrophils, and platelets, Rap1 localizes to secretory granules and is believed to regulate exocytosis or the formation of secretory granules. Rap1 has also been shown to localize in the Golgi of rat fibroblasts, zymogen granules, plasma membrane, and microsomal membrane of the pancreatic acini, as well as in the endocytic compartment of skeletal muscle cells and fibroblasts. Rap1 localizes in the nucleus of human oropharyngeal squamous cell carcinomas (SCCs) and cell lines. Rap1 plays a role in phagocytosis by controlling the binding of adhesion receptors (typically integrins) to their ligands. In yeast, Rap1 has been implicated in multiple functions, including activation and silencing of transcription and maintenance of telomeres. Probab=98.81 E-value=9.2e-09 Score=75.79 Aligned_columns=159 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.|+..-+-...-...---++.-.-.-.+....+.+|-..|...+..|.+.-+.--+ .++|| T Consensus 4 iilvGd~~VGKTsli~r~~~~~f~~~~~~ti~~~~~k~i~v~~~~~~l~iwDtaG~e~~~~l~~~~~~~a~----~~ilv 79 (163) T cd04136 4 VVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQIEVDGQQCMLEILDTAGTEQFTAMRDLYIKNGQ----GFVLV 79 (163) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCCCCCEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHCCCC----EEEEE T ss_conf 89970798438999998862800676565100012688988896899998847998035688887511688----28999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+.+| +.+++|...+. T Consensus 80 fdvt~~~Sf-~~i~~~~~~i~----------------------------------------------------------- 99 (163) T cd04136 80 YSITSQSSF-NDLQDLREQIL----------------------------------------------------------- 99 (163) T ss_pred EECCCHHHH-HHHHHHHHHHH----------------------------------------------------------- T ss_conf 756997888-99999999999----------------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) .....=.+|+++|.+|+|. ++...+-.+-.+.++-++|+..+.||++.+.|++-+...|..++ T Consensus 100 -~~~~~~~ip~ilVGNK~DL-----------~~~r~v~~~~~~~~a~~~~~~~~E~Sak~~~nv~e~F~~l~~~i 162 (163) T cd04136 100 -RVKDTENVPMVLVGNKCDL-----------EDERVVSREEGQALARQWGCPFYETSAKSKINVDEVFADLVRQI 162 (163) T ss_pred -HHCCCCCCEEEEECCCCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC T ss_conf -7408999389997244676-----------46563798999999996699599997147978789999999970 No 44 >cd01869 Rab1_Ypt1 Rab1/Ypt1 subfamily. Rab1 is found in every eukaryote and is a key regulatory component for the transport of vesicles from the ER to the Golgi apparatus. Studies on mutations of Ypt1, the yeast homolog of Rab1, showed that this protein is necessary for the budding of vesicles of the ER as well as for their transport to, and fusion with, the Golgi apparatus. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to t Probab=98.80 E-value=2.6e-08 Score=72.91 Aligned_columns=157 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+.+...-+-+|....+.-+ +....+.+|-..|...+..|......--+ .+ T Consensus 5 iv~vGd~~vGKTsli~r~~~~~f~~~y~~Tig~~~~~k~i~~~--~~~v~l~iwDt~G~e~~~~l~~~~~~~a~----~~ 78 (166) T cd01869 5 LLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELD--GKTIKLQIWDTAGQERFRTITSSYYRGAH----GI 78 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEC--CEEEEEEEEECCCCHHHHHHHHHHCCCCC----EE T ss_conf 9998269954899999875380066657601235678899998--95899998626886011231121226898----89 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+...++=. ++.|+.-++.+. T Consensus 79 iivfdit~~~Sf~~-i~~w~~~i~~~~----------------------------------------------------- 104 (166) T cd01869 79 IIVYDVTDQESFNN-VKQWLQEIDRYA----------------------------------------------------- 104 (166) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHC----------------------------------------------------- T ss_conf 99986798568999-999999998725----------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 8876230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) +-.+|+++|.+|+|.. ++.++-..-.+.+|-++|+..+.||++...|++=+...|...+. T Consensus 105 --------~~~~~~ilVGNK~Dl~-----------~~r~V~~~~~~~~a~~~~~~~~E~Sak~g~~V~e~F~~la~~i~ 164 (166) T cd01869 105 --------SENVNKLLVGNKCDLT-----------DKRVVDYSEAQEFADELGIPFLETSAKNATNVEQAFMTMAREIK 164 (166) T ss_pred --------CCCCEEEEEEECCCCC-----------CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------9982799985033333-----------24557989999999965995999971489887899999999996 No 45 >cd04137 RheB Rheb (Ras Homolog Enriched in Brain) subfamily. Rheb was initially identified in rat brain, where its expression is elevated by seizures or by long-term potentiation. It is expressed ubiquitously, with elevated levels in muscle and brain. Rheb functions as an important mediator between the tuberous sclerosis complex proteins, TSC1 and TSC2, and the mammalian target of rapamycin (TOR) kinase to stimulate cell growth. TOR kinase regulates cell growth by controlling nutrient availability, growth factors, and the energy status of the cell. TSC1 and TSC2 form a dimeric complex that has tumor suppressor activity, and TSC2 is a GTPase activating protein (GAP) for Rheb. The TSC1/TSC2 complex inhibits the activation of TOR kinase through Rheb. Rheb has also been shown to induce the formation of large cytoplasmic vacuoles in a process that is dependent on the GTPase cycle of Rheb, but independent of the TOR kinase, suggesting Rheb plays a role in endocytic trafficking that le Probab=98.79 E-value=5.9e-08 Score=70.55 Aligned_columns=177 Identities=18% Q ss_pred CEEEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCC-CCCCCCHHHHHH Q ss_conf 6588973699767899999742014688865-21456404500004325246368658624324555-678700266645 Q Ver_Hs_NP_0572 68 KNVLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLK-FSLDAVSLKDTL 145 (523) Q Consensus 68 KnILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK-~aLt~~si~~TL 145 (523) |-|+++|+.++|||+|+.|+..-+-...-.. ++-.| ...-...+..-.+.+|-..|...+..|.. +..++. - T Consensus 2 ~KIvliGd~~VGKTsli~rf~~~~f~~~y~~Ti~~~~-~k~i~v~~~~~~l~iwDtaGqe~~~~l~~~~~~~a~-----~ 75 (180) T cd04137 2 RKIAVLGSRSVGKSSLTVQFVEGHFVESYYPTIENTF-SKIIRYKGQDYHLEIVDTAGQDEYSILPQKYSIGIH-----G 75 (180) T ss_pred EEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCC-CCCEEECCEEEEEEECCCCCCCCCHHHHHHHCCCCC-----E T ss_conf 0789970798438999999861800776466100031-200356682689987478873200023366504887-----3 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 56554010136899999999999999997327898899999999999999850455566665534456766677653447 Q Ver_Hs_NP_0572 146 VMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVV 225 (523) Q Consensus 146 VvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~l 225 (523) ++||-|.+.+=+| +.++.|..-+.++...-.+ T Consensus 76 ~ilvfdit~~~Sf-~~i~~~~~~i~~~~~~~~i----------------------------------------------- 107 (180) T cd04137 76 YILVYSVTSRKSF-EVVKVIYDKILDMLGKESV----------------------------------------------- 107 (180) T ss_pred EEEEEECCCHHHH-HHHHHHHHHHHHHHCCCCC----------------------------------------------- T ss_conf 8998544897678-9999999999986189984----------------------------------------------- Q ss_pred CCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 88876230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 226 PLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 226 PLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) |+++|++|+| |..++.-.+++ ...||-++|+..|.||++.+.|++-+...|...+. T Consensus 108 -------------piiLvGNK~D----l~~~r~V~~~e-------~~~~a~~~~~~~~E~SAk~~~nV~e~F~~l~~~I~ 163 (180) T cd04137 108 -------------PIVLVGNKSD----LHTQRQVSTEE-------GKELAESWGAAFLESSARENENVEEAFELLIEEIE 163 (180) T ss_pred -------------EEEEEEECCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -------------8999420168----51236579899-------99999965997899861579888899999999999 Q ss_pred CCCCCCCCCCCCCCEEE Q ss_conf 65556556411364025 Q Ver_Hs_NP_0572 306 GFPYKIPAVVVEKDAVF 322 (523) Q Consensus 306 gfpf~~~a~ViDrD~If 322 (523) -.....+.---.+=+|+ T Consensus 164 k~~~~~~~~~~~~~~~~ 180 (180) T cd04137 164 KVENPLDPGQKKKCSIM 180 (180) T ss_pred HHCCCCCCCCCCCCEEC T ss_conf 73388888657764019 No 46 >smart00173 RAS Ras subfamily of RAS small GTPases; Similar in fold and function to the bacterial EF-Tu GTPase. p21Ras couples receptor Tyr kinases and G protein receptors to protein kinase cascades Probab=98.75 E-value=3.1e-08 Score=72.34 Aligned_columns=159 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|+.++|||+|+.++..-+-...-.. ++-.|...-.-+ +....+.+|=..|...+..|.+.-..--+ .+|| T Consensus 5 iiliGd~~vGKTsli~r~~~~~f~~~y~~ti~~~~~k~~~i~-~~~~~l~iwDtaG~e~~~~~~~~~~~~a~----~~ii 79 (166) T smart00173 5 LVVLGSGGVGKSALTIQFVQGIFVDDYDPTIEDSYRKQIEID-GEVCLLDILDTAGQEEFSAMRDQYMRTGE----GFLL 79 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEC-CEEEEEEEEECCCCCCHHHHHHHHHCCCC----CEEE T ss_conf 999807996489999998728027754552121225789898-97999998627998512367788740799----3599 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|.+.+.++-. +++|..-+.+....-++ T Consensus 80 vydit~~~Sf~~-~~~w~~~i~~~~~~~~i-------------------------------------------------- 108 (166) T smart00173 80 VYSITDRQSFEE-IKKFREQILRVKDRDDV-------------------------------------------------- 108 (166) T ss_pred EEECCCHHHHHH-HHHHHHHHHHHCCCCCC-------------------------------------------------- T ss_conf 997499789999-98998999874289995-------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 76230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) |+++|++|+|. +++..+-.+-.+.||-++|+..|.||++...|++-+..+|+-.++ T Consensus 109 ----------p~vlvgNK~Dl-----------~~~r~v~~~~~~~~a~~~~~~~~E~SAk~~~nV~e~F~~l~~~i~ 164 (166) T smart00173 109 ----------PIVLVGNKCDL-----------ENERQVSTEEGKELARQWNCPFLETSAKERINVDEAFYDLVREIR 164 (166) T ss_pred ----------EEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ----------79998114651-----------000457678999999966996999972589888899999999996 No 47 >cd04121 Rab40 Rab40 subfamily. This subfamily contains Rab40a, Rab40b, and Rab40c, which are all highly homologous. In rat, Rab40c is localized to the perinuclear recycling compartment (PRC), and is distributed in a tissue-specific manor, with high expression in brain, heart, kidney, and testis, low expression in lung and liver, and no expression in spleen and skeletal muscle. Rab40c is highly expressed in differentiated oligodendrocytes but minimally expressed in oligodendrocyte progenitors, suggesting a role in the vesicular transport of myelin components. Unlike most other Ras-superfamily proteins, Rab40c was shown to have a much lower affinity for GTP, and an affinity for GDP that is lower than for GTP. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide d Probab=98.75 E-value=4.3e-08 Score=71.44 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+.+...-|.+|....+.-+ +..-.+.+|=-.|...+.+|.+.-..--. .+ T Consensus 9 IVliGd~~VGKTSLi~rf~~~~f~~~y~~TiG~d~~~k~i~vd--g~~v~L~IWDTAGqE~f~sl~~~y~r~A~----gv 82 (235) T cd04121 9 FLLVGDSDVGKGEILASLQDGSTESPYGYNMGIDYKTTTILLD--GRRVKLQLWDTSGQGRFCTIFRSYSRGAQ----GI 82 (235) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC--CCEEEEEEEECCCCCHHHCCCHHHHCCCC----CE T ss_conf 9998169844788877642581067634302446789999885--82899998746641001100023321477----17 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+..++|-. +++|+.-++++. T Consensus 83 ILVYDIT~r~SF~~-i~~W~~ei~~~~----------------------------------------------------- 108 (235) T cd04121 83 ILVYDITNRWSFDG-IDRWIKEIDEHA----------------------------------------------------- 108 (235) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHC----------------------------------------------------- T ss_conf 99987699778999-999999998632----------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHH----HHHHHHHHH Q ss_conf 8876230058832799850741255554205774789999999999999971876888326636789----999999998 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNI----DLVYKYIVQ 302 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl----~LLykYl~H 302 (523) -++|+++|.+|+|. +++..+=..--+.||-++|+..|-||+|++.|+ .-|-+-++| T Consensus 109 ---------~~ipiILVGNK~DL-----------~~~R~Vs~eEg~~~A~~~~~~FfEtSAKtn~NV~E~F~elar~~l~ 168 (235) T cd04121 109 ---------PGVPKILVGNRLHL-----------AFKRQVATEQAQAYAERNGMTFFEVSPLCNFNITESFTELARIVLM 168 (235) T ss_pred ---------CCCEEEEEECCCCH-----------HHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHH T ss_conf ---------89659997032240-----------0237779899999999669959998536899888999999999998 Q ss_pred H Q ss_conf 7 Q Ver_Hs_NP_0572 303 K 303 (523) Q Consensus 303 r 303 (523) | T Consensus 169 ~ 169 (235) T cd04121 169 R 169 (235) T ss_pred H T ss_conf 6 No 48 >cd04138 H_N_K_Ras_like H-Ras/N-Ras/K-Ras subfamily. H-Ras, N-Ras, and K-Ras4A/4B are the prototypical members of the Ras family. These isoforms generate distinct signal outputs despite interacting with a common set of activators and effectors, and are strongly associated with oncogenic progression in tumor initiation. Mutated versions of Ras that are insensitive to GAP stimulation (and are therefore constitutively active) are found in a significant fraction of human cancers. Many Ras guanine nucleotide exchange factors (GEFs) have been identified. They are sequestered in the cytosol until activation by growth factors triggers recruitment to the plasma membrane or Golgi, where the GEF colocalizes with Ras. Active (GTP-bound) Ras interacts with several effector proteins that stimulate a variety of diverse cytoplasmic signaling activities. Some are known to positively mediate the oncogenic properties of Ras, including Raf, phosphatidylinositol 3-kinase (PI3K), RalGEFs, and Tiam1. Probab=98.74 E-value=3.2e-08 Score=72.29 Aligned_columns=158 Identities=16% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.++...+-..+-...-...+.-+-.-.+...++++|-..|...+..+.+.-+.--+ .++|| T Consensus 4 vvliGd~~VGKTSli~~~~~~~f~~~y~~Ti~~~~~k~v~i~~~~~~l~i~Dt~G~e~~~~~~~~~~~~a~----~~ilv 79 (162) T cd04138 4 LVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGE----GFLCV 79 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHCCCC----EEEEE T ss_conf 89981799548999999861801676565100147889999895899998746885013466487523897----69999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+-++ +.++.|...+. T Consensus 80 ydv~~~~Sf-~~i~~w~~~i~----------------------------------------------------------- 99 (162) T cd04138 80 FAINSRKSF-EDIHTYREQIK----------------------------------------------------------- 99 (162) T ss_pred EECCCHHHH-HHHHHHHHHHH----------------------------------------------------------- T ss_conf 866997899-99999999998----------------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) .....-.+|+++|.+|+|. +...+-..-.+.+|-++|+..+-||+|.+.|++.+...|.-++ T Consensus 100 -~~~~~~~~piilvgNK~Dl------------~~r~v~~~e~~~~a~~~~~~~~E~SAkt~~nV~e~F~~l~~~i 161 (162) T cd04138 100 -RVKDSDDVPMVLVGNKCDL------------AARTVSSRQGQDLAKSYGIPYIETSAKTRQGVEEAFYTLVREI 161 (162) T ss_pred -HHCCCCCCEEEEEEEECCC------------CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC T ss_conf -7418999489998300475------------3325898999999996699599997048978789999999971 No 49 >cd04175 Rap1 Rap1 subgroup. The Rap1 subgroup is part of the Rap subfamily of the Ras family. It can be further divided into the Rap1a and Rap1b isoforms. In humans, Rap1a and Rap1b share 95% sequence homology, but are products of two different genes located on chromosomes 1 and 12, respectively. Rap1a is sometimes called smg p21 or Krev1 in the older literature. Rap1 proteins are believed to perform different cellular functions, depending on the isoform, its subcellular localization, and the effector proteins it binds. For example, in rat salivary gland, neutrophils, and platelets, Rap1 localizes to secretory granules and is believed to regulate exocytosis or the formation of secretory granules. Rap1 has also been shown to localize in the Golgi of rat fibroblasts, zymogen granules, plasma membrane, and the microsomal membrane of pancreatic acini, as well as in the endocytic compartment of skeletal muscle cells and fibroblasts. High expression of Rap1 has been observed in the n Probab=98.73 E-value=7.6e-08 Score=69.82 Aligned_columns=157 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.|+.. .+++.-.-+-.|.-.-..|...-. +.+|-..|...+..+.+.-..--+ .+ T Consensus 4 ivlvGd~~VGKTsli~r~~~~~f~~~y~~Ti~~~~~k~i~~~~~~~~---l~iwDtaG~e~~~~~~~~~~~~a~----~~ 76 (164) T cd04175 4 LVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDGQQCM---LEILDTAGTEQFTAMRDLYMKNGQ----GF 76 (164) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCEEEE---EEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 89980798538999999862800665575312136899988894899---998727998202357675505898----79 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+.+| +.++.|..-++ T Consensus 77 ilvydit~~~Sf-~~i~~~~~~i~-------------------------------------------------------- 99 (164) T cd04175 77 VLVYSITAQSTF-NDLQDLREQIL-------------------------------------------------------- 99 (164) T ss_pred EEEEECCCHHHH-HHHHHHHHHHH-------------------------------------------------------- T ss_conf 999866997788-99999988888-------------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 8876230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) .....-.+|+++|.+|+|. +++..+-.+-.+.+|-++|+..|-||+|.+.|++-+...|.-++. T Consensus 100 ----~~~~~~~ip~vlvGNK~DL-----------~~~r~V~~~~~~~~a~~~~~~~~E~Sak~~~nV~e~F~~l~~~i~ 163 (164) T cd04175 100 ----RVKDTEDVPMILVGNKCDL-----------EDERVVGKEQGQNLARQWGCAFLETSAKAKINVNEIFYDLVRQIN 163 (164) T ss_pred ----HHCCCCCCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHC T ss_conf ----6408998579998125653-----------000334078999999965993899971479887899999999962 No 50 >cd04159 Arl10_like Arl10-like subfamily. Arl9/Arl10 was identified from a human cancer-derived EST dataset. No functional information about the subfamily is available at the current time, but crystal structures of human Arl10b and Arl10c have been solved. Probab=98.73 E-value=7.3e-08 Score=69.95 Aligned_columns=155 Identities=26% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 88973699767899999742014688865-21456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) |+++|..++|||||+.+|..-+-..+... +++.+..|...+ .++.+|-+.|...+.++.+.-..--. .+|+ T Consensus 2 IvivG~~~vGKTsl~~~~~~~~f~~~~~~Tig~~~~~i~~~~----~~l~iwDtaGqe~~~~~~~~y~~~a~----~ii~ 73 (159) T cd04159 2 ITLVGLQNSGKTTLVNVIAGGQFSEDTIPTVGFNMRKVTKGN----VTLKVWDLGGQPRFRSMWERYCRGVN----AIVY 73 (159) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEEEEEEEEECC----EEEEEEECCCCHHHHHHHHHHHHCCC----CEEE T ss_conf 789942898689999987549416532300002799988477----89999855873135788987631048----5179 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |.|.+.+ ++++.....+++.+.... T Consensus 74 V~D~td~----~s~~~~~~~l~~ll~~~~--------------------------------------------------- 98 (159) T cd04159 74 VVDAADR----TALEAAKNELHDLLEKPS--------------------------------------------------- 98 (159) T ss_pred EEECCCH----HHHHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 9854886----678999999998751037--------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH Q ss_conf 7623005883279985074125555420577478999999999999997187688832663678999999999 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIV 301 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~ 301 (523) .-++|++||++|+|.-+....+ +++...--...-+..-..+-||+|...|++-...+|. T Consensus 99 ------~~~ipili~gNK~Dl~~~~~~~--------e~~~~~~~~~~~~~~~~~~~~SAktg~gI~e~f~wL~ 157 (159) T cd04159 99 ------LEGIPLLVLGNKNDLPGALSVD--------ELIEQMNLKSITDREVSCYSISCKEKTNIDIVLDWLI 157 (159) T ss_pred ------CCCCEEEEEECCCCCCCCCCHH--------HHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH T ss_conf ------7995799981246842125888--------9999998999851894589986147988899999985 No 51 >cd04111 Rab39 Rab39 subfamily. Found in eukaryotes, Rab39 is mainly found in epithelial cell lines, but is distributed widely in various human tissues and cell lines. It is believed to be a novel Rab protein involved in regulating Golgi-associated vesicular transport during cellular endocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=98.73 E-value=6.3e-08 Score=70.35 Aligned_columns=158 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHH- Q ss_conf 88973699767899999742---01468886521456404500004325246368658624324555678700266645- Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTL- 145 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TL- 145 (523) |+++|+.++|||+|+.++.. .+.+...-|.+|..-.|.=+|.. ...+.+|=..|..-+. .++..-++++. T Consensus 5 IviiGd~~VGKTsli~rf~~~~F~~~~~~Tig~df~~k~v~i~dgk-~v~L~IwDTaGqE~f~-----si~~~yyr~a~g 78 (211) T cd04111 5 LIVIGDSTVGKSSLLKRFTEGRFAEVSDPTVGVDFFSRLIEIEPGV-RIKLQLWDTAGQERFR-----SITRSYYRNSVG 78 (211) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCEEEEEEEEEEEECCCC-EEEEEEEECCCCHHHH-----HHHHHHHCCCCE T ss_conf 9998269854899998877082167656502468889999961784-7999986369971568-----888886018988 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 56554010136899999999999999997327898899999999999999850455566665534456766677653447 Q Ver_Hs_NP_0572 146 VMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVV 225 (523) Q Consensus 146 VvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~l 225 (523) +++|-|.+.+ .=.+.|..|+.-++.|...-.+ T Consensus 79 ~ilVyDit~~-~SFe~i~~w~~ei~~~~~~~~~----------------------------------------------- 110 (211) T cd04111 79 VLLVFDITNR-ESFEHVHDWLEEARSHIQPHRP----------------------------------------------- 110 (211) T ss_pred EEEEEECCCH-HHHHHHHHHHHHHHHHCCCCCC----------------------------------------------- T ss_conf 9999866997-7899999999999985189985----------------------------------------------- Q ss_pred CCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 88876230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 226 PLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 226 PLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) |+++|.+|+|. +++..+=..--+.+|-++|+..|.||+|...|++-+...|.-++| T Consensus 111 -------------~~iLVGNK~DL-----------~~~R~Vs~eea~~~A~~~~~~f~EtSAktg~nV~e~F~~la~~I~ 166 (211) T cd04111 111 -------------VFILVGHKCDL-----------ESQRQVTREEAEKLAKDLGMKYIETSARTGDNVEEAFELLTQEIY 166 (211) T ss_pred -------------EEEEECCCCCH-----------HHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -------------89997165341-----------333012489999999966996999963589888999999999999 No 52 >cd04134 Rho3 Rho3 subfamily. Rho3 is a member of the Rho family found only in fungi. Rho3 is believed to regulate cell polarity by interacting with the diaphanous/formin family protein For3 to control both the actin cytoskeleton and microtubules. Rho3 is also believed to have a direct role in exocytosis that is independent of its role in regulating actin polarity. The function in exocytosis may be two-pronged: first, in the transport of post-Golgi vesicles from the mother cell to the bud, mediated by myosin (Myo2); second, in the docking and fusion of vesicles to the plasma membrane, mediated by an exocyst (Exo70) protein. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Probab=98.72 E-value=4.7e-08 Score=71.19 Aligned_columns=179 Identities=21% Q ss_pred CEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHH-HHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 65889736997678999997420146888652145640450000432-52463686586243245556787002666455 Q Ver_Hs_NP_0572 68 KNVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQ-TRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 68 KnILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~-ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) +-|+++|+.++|||+|+.++..-.-...-...-+..+ ++.-..|+. -.+.+|=-.|...+..|.+....--+ .+ T Consensus 1 ~KiiliGd~~VGKTsLi~rf~~~~F~~~~~~Ti~~~~-~~~i~vd~~~v~l~iwDTaGqE~f~~l~~~~y~~a~----~~ 75 (189) T cd04134 1 RKVVVLGDGACGKTSLLNVFTRGYFPQVYEPTVFENY-VHDIFVDGLHIELSLWDTAGQEEFDRLRSLSYADTD----VI 75 (189) T ss_pred CEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEE-EEEEEECCEEEEEEEECCCCCHHHHHHHHHHHCCCC----EE T ss_conf 9689982698338999988763800675166167756-786677794899998627787145778887733898----78 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|++.+.+|-.-..+|+.-++++. T Consensus 76 ilvydit~~~Sf~~i~~~W~~ei~~~~----------------------------------------------------- 102 (189) T cd04134 76 MLCFSVDSPDSLENVESKWLGEIREHC----------------------------------------------------- 102 (189) T ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHC----------------------------------------------------- T ss_conf 999866884466899998899999835----------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHH-HHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHHHHH Q ss_conf 8876230058832799850741255554205774789999999-999999971876888-32663678999999999876 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQS-HIRKFCLRYGAALIY-TSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq-~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~HrL 304 (523) -++|+++|.+|+|..+.-+....-..++-..+.. --..++-.+||-.+| ||+|.+.|++-+..++.... T Consensus 103 ---------~~v~iiLVGnK~DL~~~~~~~~~~~~~~~~~vs~~e~~~~a~~~~~~~y~EtSAKt~~nV~e~F~~lar~~ 173 (189) T cd04134 103 ---------PGVKLVLVALKCDLREARNERDDLQRYGKHTISYEEGLAVAKRINALRYLECSAKLNRGVNEAFTEAARVA 173 (189) T ss_pred ---------CCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHH T ss_conf ---------89559998504676553134566765313677989999999980895068864257878789999999998 Q ss_pred CCCCCCCCC Q ss_conf 065556556 Q Ver_Hs_NP_0572 305 YGFPYKIPA 313 (523) Q Consensus 305 ygfpf~~~a 313 (523) ......+|+ T Consensus 174 L~~~~~~~~ 182 (189) T cd04134 174 LNVRPPHPH 182 (189) T ss_pred HCCCCCCCC T ss_conf 278877887 No 53 >cd04141 Rit_Rin_Ric Rit/Rin/Ric subfamily. Rit (Ras-like protein in all tissues), Rin (Ras-like protein in neurons) and Ric (Ras-related protein which interacts with calmodulin) form a subfamily with several unique structural and functional characteristics. These proteins all lack a the C-terminal CaaX lipid-binding motif typical of Ras family proteins, and Rin and Ric contain calmodulin-binding domains. Rin, which is expressed only in neurons, induces neurite outgrowth in rat pheochromocytoma cells through its association with calmodulin and its activation of endogenous Rac/cdc42. Rit, which is ubiquitously expressed in mammals, inhibits growth-factor withdrawl-mediated apoptosis and induces neurite extension in pheochromocytoma cells. Rit and Rin are both able to form a ternary complex with PAR6, a cell polarity-regulating protein, and Rac/cdc42. This ternary complex is proposed to have physiological function in processes such as tumorigenesis. Activated Ric is likely to sign Probab=98.70 E-value=5.6e-08 Score=70.69 Aligned_columns=160 Identities=12% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.++..-+-...-..--...+...=.-.+..-++.+|-..|..-+.+|.+.-+.--. .+||| T Consensus 5 i~liGd~~VGKTsli~rf~~~~F~~~y~pTi~~~~~~~i~~~~~~v~l~iwDtaGqe~~~~l~~~~~~~a~----~~ilV 80 (172) T cd04141 5 IVMLGAGGVGKSAVTMQFISHSFPDYHDPTIEDAYKQQARIDNEPALLDILDTAGQAEFTAMRDQYMRCGE----GFIIC 80 (172) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCEEEEEEEECCCCCHHHHHHHHHHCCCCC----EEEEE T ss_conf 99970798438999999872822776566300004789989795899986227762135567687514997----38998 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+-+| +.+..|.+.+. T Consensus 81 yditd~~Sf-~~i~~w~~~i~----------------------------------------------------------- 100 (172) T cd04141 81 YSVTDRHSF-QEASEFKKLIT----------------------------------------------------------- 100 (172) T ss_pred EECCCHHHH-HHHHHHHHHHH----------------------------------------------------------- T ss_conf 542897689-99999999999----------------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 6230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) .....=.+|+++|.+|+|. +++..+-.+-.+.+|-.+|+..+-||+|.+.|++-+...|...++ T Consensus 101 -~~~~~~~~pivlvgNK~DL-----------~~~r~V~~~e~~~~a~~~~~~f~EtSAk~~~nV~~~F~~l~~~i~ 164 (172) T cd04141 101 -RVRLTEDIPLVLVGNKVDL-----------ESQRQVTTEEGRNLAREFNCPFFETSAALRHYIDDAFHGLVREIR 164 (172) T ss_pred -HHCCCCCCEEEEEECCCHH-----------HHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -7407999779998156016-----------541566778999999965996999970589887899999999999 No 54 >cd04118 Rab24 Rab24 subfamily. Rab24 is distinct from other Rabs in several ways. It exists primarily in the GTP-bound state, having a low intrinsic GTPase activity; it is not efficiently geranyl-geranylated at the C-terminus; it does not form a detectable complex with Rab GDP-dissociation inhibitors (GDIs); and it has recently been shown to undergo tyrosine phosphorylation when overexpressed in vitro. The specific function of Rab24 still remains unknown. It is found in a transport route between ER-cis-Golgi and late endocytic compartments. It is putatively involved in an autophagic pathway, possibly directing misfolded proteins in the ER to degradative pathways. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilita Probab=98.70 E-value=5e-08 Score=70.98 Aligned_columns=162 Identities=15% Q ss_pred EEEEECCCCCHHHHHHHHHHCC--CCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHH Q ss_conf 8897369976789999974201--46888652145640450000432524636865862432455567870026664556 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIE--EYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVM 147 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e--~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVv 147 (523) |+++|+.++|||+|+.|...-+ +..-..-++..|..-.-...+..-.+.+|=..|...+.+|.+.-..--+ .++ T Consensus 3 vvliGd~~VGKTsli~r~~~~~F~~~~y~~Tig~~f~~k~i~~~~~~v~l~iwDtaGqe~~~~l~~~~yr~a~----~~i 78 (193) T cd04118 3 VVMLGKESVGKTSLVERYVHHRFLVGPYQNTIGAAFVAKRMVVGERVVTLGIWDTAGSERYEAMSRIYYRGAK----AAI 78 (193) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHCCCC----EEE T ss_conf 8998079832899988875273168874661332358888643875799998638875357898987612887----389 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 55401013689999999999999999732789889999999999999985045556666553445676667765344788 Q Ver_Hs_NP_0572 148 LVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPL 227 (523) Q Consensus 148 IvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPL 227 (523) ||-|.+.+-+| +.|+.|+.-++++-.. T Consensus 79 lvydit~~~SF-~~l~~w~~~i~~~~~~---------------------------------------------------- 105 (193) T cd04118 79 VCYDLTDSSSF-ERAKFWVKELQNLEEH---------------------------------------------------- 105 (193) T ss_pred EEEECCCCHHH-HHHHHHHHHHHHCCCC---------------------------------------------------- T ss_conf 99874881017-8999999998621899---------------------------------------------------- Q ss_pred CCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 876230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 228 GADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 228 geg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) +|+++|.+|+|..+.-+..+....|+. +.+|=++|+..|.||+|...|++-+..+|.-.+. T Consensus 106 ----------~~iilVGNK~DL~~~~~~~r~V~~ee~-------~~~A~~~~~~~fEtSAktg~nV~elF~~ia~~i~ 166 (193) T cd04118 106 ----------CKIYLCGTKSDLIEQDRSLRQVDFHDV-------QDFADEIKAQHFETSSKTGQNVDELFQKVAEDFV 166 (193) T ss_pred ----------CEEEEEECCCCHHHCCCCCCCCCHHHH-------HHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ----------789998414221120666444688999-------9999966995999962589888899999999999 No 55 >cd04160 Arfrp1 Arfrp1 subfamily. Arfrp1 (Arf-related protein 1), formerly known as ARP, is a membrane-associated Arf family member that lacks the N-terminal myristoylation motif. Arfrp1 is mainly associated with the trans-Golgi compartment and the trans-Golgi network, where it regulates the targeting of Arl1 and the GRIP domain-containing proteins, golgin-97 and golgin-245, onto Golgi membranes. It is also involved in the anterograde transport of the vesicular stomatitis virus G protein from the Golgi to the plasma membrane, and in the retrograde transport of TGN38 and Shiga toxin from endosomes to the trans-Golgi network. Arfrp1 also inhibits Arf/Sec7-dependent activation of phospholipase D. Deletion of Arfrp1 in mice causes embryonic lethality at the gastrulation stage and apoptosis of mesodermal cells, indicating its importance in development. Probab=98.70 E-value=1.1e-07 Score=68.83 Aligned_columns=158 Identities=26% Q ss_pred EEEEEECCCCCHHHHHHHHHHCCCCCCCC---------CCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCC Q ss_conf 58897369976789999974201468886---------521456404500004325246368658624324555678700 Q Ver_Hs_NP_0572 69 NVLLLGEDGAGKTSLIRKIQGIEEYKKGR---------GLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAV 139 (523) Q Consensus 69 nILvLG~~~sGKTtLl~~Lq~~e~~kKg~---------gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~ 139 (523) +||++|..++|||||+.+|+.....-++. |..+..+.+.+ .++.+|-+.|...+..+.+.-..-- T Consensus 1 ~IvliG~~~~GKTsll~rl~~~~~~~~~~~~~~~~~T~g~~~~~i~~~~------~~l~iwD~~Gqe~~~~~~~~y~~~a 74 (167) T cd04160 1 SVLILGLDNAGKTTFLEQLKTLFSKYKGLPPSKITPTVGLNIGTIEVGN------ARLKFWDLGGQESLRSLWDKYYAEC 74 (167) T ss_pred CEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEECC------EEEEEEECCCCHHHHHHHHHHCCCC T ss_conf 9789951898689999998520244567544403335545898888878------8999984687404677676415798 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC Q ss_conf 26664556554010136899999999999999997327898899999999999999850455566665534456766677 Q Ver_Hs_NP_0572 140 SLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDK 219 (523) Q Consensus 140 si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~ 219 (523) . .||+|+|.+.+-.+-+....|-.++++.-.. T Consensus 75 ~----~ii~VvD~sd~~~~~~~~~~l~~~l~~~~~~-------------------------------------------- 106 (167) T cd04160 75 H----AIIYVIDSTDRERFEESKSALEKVLRNEALE-------------------------------------------- 106 (167) T ss_pred C----EEEEEEECCCCCCHHHHHHHHHHHHHCCCCC-------------------------------------------- T ss_conf 6----7999974487535688999999997221558-------------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHH Q ss_conf 65344788876230058832799850741255554205774789999999999999971876888326636789999999 Q Ver_Hs_NP_0572 220 DDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKY 299 (523) Q Consensus 220 d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykY 299 (523) ++|++|+++|+|.-. ....|+..-+.+-.-..+-+..-.++.||++...+++-...+ T Consensus 107 -----------------~~Pili~~NK~Dl~~------~~~~eei~~~l~~~~~~~~~r~~~~~~~SA~tG~Gv~e~f~w 163 (167) T cd04160 107 -----------------GVPLLILANKQDLPD------ALSVEEIKEVFQDKAEEIGRRDCLVLPVSALEGTGVREGIEW 163 (167) T ss_pred -----------------CCEEEEEECCCCCCC------CCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH T ss_conf -----------------977999834879531------237889999999889987408917999851368888999999 Q ss_pred HHHH Q ss_conf 9987 Q Ver_Hs_NP_0572 300 IVQK 303 (523) Q Consensus 300 l~Hr 303 (523) |+-| T Consensus 164 L~~k 167 (167) T cd04160 164 LVER 167 (167) T ss_pred HHCC T ss_conf 8429 No 56 >cd04152 Arl4_Arl7 Arl4/Arl7 subfamily. Arl4 (Arf-like 4) is highly expressed in testicular germ cells, and is found in the nucleus and nucleolus. In mice, Arl4 is developmentally expressed during embryogenesis, and a role in somite formation and central nervous system differentiation has been proposed. Arl7 has been identified as the only Arf/Arl protein to be induced by agonists of liver X-receptor and retinoid X-receptor and by cholesterol loading in human macrophages. Arl7 is proposed to play a role in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Older literature suggests that Arl6 is a part of the Arl4/Arl7 subfamily, but analyses based on more recent sequence data place Arl6 in its own subfamily. Probab=98.69 E-value=2.6e-07 Score=66.37 Aligned_columns=164 Identities=15% Q ss_pred EEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHH-HHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHH Q ss_conf 5889736997678999997420146888652145640450000432-524636865862432455567870026664556 Q Ver_Hs_NP_0572 69 NVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQ-TRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVM 147 (523) Q Consensus 69 nILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~-ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVv 147 (523) .|+++|..++|||||+.++..-+-...---.++.+..+.-...+.. -++.+|-+.|...+.+|.+.-..--. .+| T Consensus 5 kIvilG~~~~GKTsil~r~~~~~~~~~~pT~g~~~~~~~~~~~~~~~v~l~iwD~aGqe~~r~l~~~yy~~a~----giI 80 (183) T cd04152 5 HIVMLGLDSAGKTTVLYRLKFNEFVNTVPTKGFNTEKIKVSLGNSKGITFHFWDVGGQEKLRPLWKSYTRCTD----GIV 80 (183) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCEECCEEEEEEEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHCCCCC----EEE T ss_conf 9999850898689988876448211100220334788987504774279999864885025675531136886----799 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 55401013689999999999999999732789889999999999999985045556666553445676667765344788 Q Ver_Hs_NP_0572 148 LVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPL 227 (523) Q Consensus 148 IvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPL 227 (523) +|.|.+.. .-+++.+.|+.-+. T Consensus 81 ~V~D~sd~-~~~~~~~~~l~~i~--------------------------------------------------------- 102 (183) T cd04152 81 FVVDSVDV-ERMEEAKTELHKIT--------------------------------------------------------- 102 (183) T ss_pred EEEECCCH-HHHHHHHHHHHHHH--------------------------------------------------------- T ss_conf 99853783-46899999999997--------------------------------------------------------- Q ss_pred CCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 87623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 228 GADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 228 geg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) ...++-++|++||..|+|.-. .+..++..-.. .++.++-.++-.++-||++...++.=....|.-.+ T Consensus 103 ---~~~~~~~~piLi~~NK~Dl~~------~~~~~e~~~~~-~l~~~~~~~~~~~~~~SA~tG~Gi~e~f~~L~~~i 169 (183) T cd04152 103 ---RFSENQGVPVLVLANKQDLPN------ALSVSEVEKLL-ALHELSASTPWHVQPACAIIGEGLQEGLEKLYEMI 169 (183) T ss_pred ---HCCCCCCCEEEEEECCCCCCC------CCCHHHHHHHH-HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHH T ss_conf ---112678978999961678764------67889999998-88999851896798740467878889999999999 No 57 >cd04133 Rop_like Rop subfamily. The Rop (Rho-related protein from plants) subfamily plays a role in diverse cellular processes, including cytoskeletal organization, pollen and vegetative cell growth, hormone responses, stress responses, and pathogen resistance. Rops are able to regulate several downstream pathways to amplify a specific signal by acting as master switches early in the signaling cascade. They transmit a variety of extracellular and intracellular signals. Rops are involved in establishing cell polarity in root-hair development, root-hair elongation, pollen-tube growth, cell-shape formation, responses to hormones such as abscisic acid (ABA) and auxin, responses to abiotic stresses such as oxygen deprivation, and disease resistance and disease susceptibility. An individual Rop can have a unique function or an overlapping function shared with other Rop proteins; in addition, a given Rop-regulated function can be controlled by one or multiple Rop proteins. For example, Probab=98.69 E-value=9.2e-08 Score=69.29 Aligned_columns=162 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |++||+.++|||+|+.++..-.-...-...-...+...-.-....-++.+|=-.|...+..|.+....--+ .++|| T Consensus 4 iv~iGd~~VGKTsLi~rf~~~~F~~~~~pTi~~~~~~~i~~~~~~v~l~IwDTaGqe~~~~l~~~~~r~a~----~~ilv 79 (176) T cd04133 4 CVTVGDGAVGKTCMLICYTSNKFPTDYIPTVFDNFSANVSVDGNTVNLGLWDTAGQEDYNRLRPLSYRGAD----VFVLA 79 (176) T ss_pred EEEECCCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHCCCCC----EEEEE T ss_conf 99971798448998888753801686353353111367888894899998756887146788887411447----26999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+-++-.-+++|+.-++.+- T Consensus 80 ydvt~~~Sf~~~~~~w~~~~~~~~-------------------------------------------------------- 103 (176) T cd04133 80 FSLISRASYENVLKKWVPELRHYA-------------------------------------------------------- 103 (176) T ss_pred EECCCCHHHHHHHHHHHHHHHHHC-------------------------------------------------------- T ss_conf 744872207999999899999727-------------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHH----------HHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHH Q ss_conf 623005883279985074125555420577478999----------9999999999971876888-32663678999999 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFD----------FFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYK 298 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fD----------fIqq~LR~icL~YGAaLiY-TS~ke~knl~LLyk 298 (523) -.+|+++|.+|+|. .++.. +-..--..+|-++|+.+++ ||+|...|++-+.. T Consensus 104 ------~~~piiLVGNK~DL-----------~~~r~~~~~~~~~~~v~~~e~~~~a~~~~~~~y~EtSAktg~nV~e~F~ 166 (176) T cd04133 104 ------PNVPIVLVGTKLDL-----------RDDKQYLADHPGASPITTAQGEELRKQIGAAAYIECSSKTQQNVKAVFD 166 (176) T ss_pred ------CCCEEEEEECCCCC-----------HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH T ss_conf ------99489997057551-----------1124566530133543678999999963997489975137878789999 Q ss_pred HHHHHHCCCC Q ss_conf 9998760655 Q Ver_Hs_NP_0572 299 YIVQKLYGFP 308 (523) Q Consensus 299 Yl~HrLygfp 308 (523) ++.-.+.-.| T Consensus 167 ~~~r~vl~~~ 176 (176) T cd04133 167 AAIKVVLQPP 176 (176) T ss_pred HHHHHHHCCC T ss_conf 9999971689 No 58 >cd04146 RERG_RasL11_like RERG/RasL11-like subfamily. RERG (Ras-related and Estrogen- Regulated Growth inhibitor) and Ras-like 11 are members of a novel subfamily of Ras that were identified based on their behavior in breast and prostate tumors, respectively. RERG expression was decreased or lost in a significant fraction of primary human breast tumors that lack estrogen receptor and are correlated with poor clinical prognosis. Elevated RERG expression correlated with favorable patient outcome in a breast tumor subtype that is positive for estrogen receptor expression. In contrast to most Ras proteins, RERG overexpression inhibited the growth of breast tumor cells in vitro and in vivo. RasL11 was found to be ubiquitously expressed in human tissue, but down-regulated in prostate tumors. Both RERG and RasL11 lack the C-terminal CaaX prenylation motif, where a = an aliphatic amino acid and X = any amino acid, and are localized primarily in the cytoplasm. Both are believed to have tu Probab=98.66 E-value=9.2e-08 Score=69.28 Aligned_columns=157 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHH-H Q ss_conf 88973699767899999742---0146888652145640450000432524636865862432455567870026664-5 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDT-L 145 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~T-L 145 (523) |+++|+.++|||+|+.++.. .+++....+-.|.-.-.-|.. .-++.+|-..|...+..+... ..++.+ . T Consensus 2 Iv~iGd~~vGKTsLi~r~~~~~F~~~y~~ti~~~~~k~~~v~~~---~v~l~i~DtaG~e~~~~~~~~----~~~~~ad~ 74 (165) T cd04146 2 IAVLGASGVGKSALVVRFLTKRFIGEYDPNLESLYSRQVTIDGE---QVSLEILDTAGQQQADTEQLE----RSIRWADG 74 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHEEEEEECCC---EEEEEEECCCCCHHHHHHCCC----CCCCCCCE T ss_conf 78881798328999999861744775463012111000022594---489997227772011000001----35468887 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 56554010136899999999999999997327898899999999999999850455566665534456766677653447 Q Ver_Hs_NP_0572 146 VMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVV 225 (523) Q Consensus 146 VvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~l 225 (523) +|||-|.+.+-+| +.++.|...++++-.... T Consensus 75 ~ilvydit~~~SF-~~i~~~~~~i~~~~~~~~------------------------------------------------ 105 (165) T cd04146 75 FVLVYSITDRSSF-DEISQLKQLIREIKKRDR------------------------------------------------ 105 (165) T ss_pred EEEEEECCCHHHH-HHHHHHHHHHHHHCCCCC------------------------------------------------ T ss_conf 9999766985368-999999999997514799------------------------------------------------ Q ss_pred CCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCH-HHHHHHHHHHHHHH Q ss_conf 88876230058832799850741255554205774789999999999999971876888326636-78999999999876 Q Ver_Hs_NP_0572 226 PLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKEN-KNIDLVYKYIVQKL 304 (523) Q Consensus 226 PLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~-knl~LLykYl~HrL 304 (523) .+|+++|++|+|. ++...+-..-.+.+|-++|+..+.||+|.+ .|++-+...|..++ T Consensus 106 -----------~~piilVGNK~DL-----------~~~r~V~~ee~~~~a~~~~~~~~E~SAk~~~~~V~e~F~~l~~~i 163 (165) T cd04146 106 -----------EIPVILVGNKADL-----------LHYRQVSTEEGEKLASELGCLFFEVSAAEDYDGVHSVFHELCREV 163 (165) T ss_pred -----------CCEEEEECCCCCC-----------HHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHH T ss_conf -----------8279997233360-----------010546989999999965995899860458802799999999997 No 59 >cd01870 RhoA_like RhoA-like subfamily. The RhoA subfamily consists of RhoA, RhoB, and RhoC. RhoA promotes the formation of stress fibers and focal adhesions, regulating cell shape, attachment, and motility. RhoA can bind to multiple effector proteins, thereby triggering different downstream responses. In many cell types, RhoA mediates local assembly of the contractile ring, which is necessary for cytokinesis. RhoA is vital for muscle contraction; in vascular smooth muscle cells, RhoA plays a key role in cell contraction, differentiation, migration, and proliferation. RhoA activities appear to be elaborately regulated in a time- and space-dependent manner to control cytoskeletal changes. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. RhoA and RhoC are observed only in geranyl Probab=98.63 E-value=9e-08 Score=69.34 Aligned_columns=161 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.++..-.-...-...-..-+...=.-.+...++.+|=-.|...+.+|-+....--+ .++|| T Consensus 4 iiliGd~~VGKTsli~r~~~~~F~~~~~pTi~~~~~~~i~i~~~~v~l~iwDtaGqe~~~~l~~~~~~~a~----~~ilv 79 (175) T cd01870 4 LVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTD----VILMC 79 (175) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHCCCC----EEEEE T ss_conf 89982698438999999863823665254022136899989896999987058620246677787504898----48999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+.++-.-.+.|+..++... T Consensus 80 ydi~~~~Sf~~i~~~W~~~~~~~~-------------------------------------------------------- 103 (175) T cd01870 80 FSIDSPDSLENIPEKWTPEVKHFC-------------------------------------------------------- 103 (175) T ss_pred EECCCHHHHHHHHHHHHHHHHHHC-------------------------------------------------------- T ss_conf 766865578999998899999725-------------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCH------HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHH Q ss_conf 62300588327998507412------55554205774789999999999999971876888-32663678999999999 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDA------ISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYKYIV 301 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~------ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~ 301 (523) -.+|+++|.+|+|. ++-+.+. .+..+-.+--+.++-++|+-.+| ||+|.+.|++-+...+. T Consensus 104 ------~~~piiLvgnK~DL~~~~~~~~~~~~~-----~~~~v~~~eg~~~a~~~~~~~y~E~SAktg~nV~e~Fe~~~ 171 (175) T cd01870 104 ------PNVPIILVGNKKDLRNDEHTRRELAKM-----KQEPVKPEEGRDMANKIGAFGYMECSAKTKEGVREVFEMAT 171 (175) T ss_pred ------CCCEEEEEECCCCCCCCHHHHHHHHHH-----CCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH T ss_conf ------895299985154433431467766541-----04677989999999973997289874148888789999999 No 60 >cd00878 Arf_Arl Arf (ADP-ribosylation factor)/Arl (Arf-like) small GTPases. Arf proteins are activators of phospholipase D isoforms. Unlike Ras proteins they lack cysteine residues at their C-termini and therefore are unlikely to be prenylated. Arfs are N-terminally myristoylated. Members of the Arf family are regulators of vesicle formation in intracellular traffic that interact reversibly with membranes of the secretory and endocytic compartments in a GTP-dependent manner. They depart from other small GTP-binding proteins by a unique structural device, interswitch toggle, that implements front-back communication from N-terminus to the nucleotide binding site. Arf-like (Arl) proteins are close relatives of the Arf, but only Arl1 has been shown to function in membrane traffic like the Arf proteins. Arl2 has an unrelated function in the folding of native tubulin, and Arl4 may function in the nucleus. Most other Arf family proteins are so far relatively poorly characterized. Thu Probab=98.61 E-value=1.5e-07 Score=67.82 Aligned_columns=156 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|..++|||||+.++..-+-...---+++.|-.+.-.. .++++|-+.|...+.++.+.-..--+ .+|+| T Consensus 2 iviiG~~~vGKTsli~~~~~~~~~~~~pTig~~~~~i~~~~----~~~~i~D~~G~~~~~~l~~~y~~~a~----~iI~V 73 (158) T cd00878 2 ILILGLDGAGKTTILYKLKLGEVVTTIPTIGFNVETVEYKN----VSFTVWDVGGQDKIRPLWKHYYENTN----GIIFV 73 (158) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCEEEEEEEEEEEEECCC----EEEEEEECCCCCCCHHHHHHHCCCCC----EEEEE T ss_conf 78884399878999999864823312202542688853041----48999865898520467786614898----17999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) .|.+.+ .-+++++.|+.-+..|-. .+ T Consensus 74 ~D~sd~-~s~~~~~~~~~~~~~~~~-~~---------------------------------------------------- 99 (158) T cd00878 74 VDSSDR-ERIEEAKEELHKLLNEEE-LK---------------------------------------------------- 99 (158) T ss_pred EECCCC-CCHHHHHHHHHHHHHHCC-CC---------------------------------------------------- T ss_conf 843776-557899999999852114-48---------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHH Q ss_conf 6230058832799850741255554205774789999999999999971876888326636789999999998 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQ 302 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~H 302 (523) ++|++||++|+|.-..+..+ ++.+.+=..-+.+..-.++.||+|...+++=...+|+. T Consensus 100 -------~~pili~~NK~Dl~~~~~~~--------ei~~~~~l~~~~~~~~~~~~~SAktg~gI~e~f~wL~~ 157 (158) T cd00878 100 -------GVPLLIFANKQDLPGALSVS--------ELIEKLGLEKILGRRWHIQPCSAVTGDGLDEGLDWLLQ 157 (158) T ss_pred -------CCEEEEEEECCCCCCCCCHH--------HHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHC T ss_conf -------94367554011653347988--------99999877776059648998751258788999999852 No 61 >cd04135 Tc10 TC10 subfamily. TC10 is a Rho family protein that has been shown to induce microspike formation and neurite outgrowth in vitro. Its expression changes dramatically after peripheral nerve injury, suggesting an important role in promoting axonal outgrowth and regeneration. TC10 regulates translocation of insulin-stimulated GLUT4 in adipocytes and has also been shown to bind directly to Golgi COPI coat proteins. GTP-bound TC10 in vitro can bind numerous potential effectors. Depending on its subcellular localization and distinct functional domains, TC10 can differentially regulate two types of filamentous actin in adipocytes. TC10 mRNAs are highly expressed in three types of mouse muscle tissues: leg skeletal muscle, cardiac muscle, and uterus; they were also present in brain, with higher levels in adults than in newborns. TC10 has also been shown to play a role in regulating the expression of cystic fibrosis transmembrane conductance regulator (CFTR) through interacti Probab=98.60 E-value=8e-08 Score=69.66 Aligned_columns=161 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.++..-+-..+-...-.-.+...=.-.+....+.+|=-.|...+..|.+....--+ .++|| T Consensus 3 ivliGd~~VGKTsLi~~~~~~~F~~~~~~Ti~~~~~~~i~i~~~~~~l~iwDtaGqe~~~~~~~~~~~~a~----~~ilv 78 (174) T cd04135 3 CVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTD----VFLIC 78 (174) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCEEEEEEEECCCCCHHHHHHHHHHCCCCC----EEEEE T ss_conf 89970798438999998761831676455144033200356886899987168887026778897548998----79999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+.++-.=-+.|+..++.+..+ T Consensus 79 ydit~~~Sf~~i~~~w~~~~~~~~~~------------------------------------------------------ 104 (174) T cd04135 79 FSVVNPASFQNVKEEWVPELKEYAPN------------------------------------------------------ 104 (174) T ss_pred EECCCHHHHHHHHHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 65586324899999989999861799------------------------------------------------------ Q ss_pred CCCCCCCCCCEEEEEECCCH------HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHH Q ss_conf 62300588327998507412------55554205774789999999999999971876888-32663678999999999 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDA------ISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYKYIV 301 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~------ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~ 301 (523) +|+++|.+|+|. +..+... ++..+-..--+.+|-++|+-.+| ||+|...|++-+...+. T Consensus 105 --------~piilVGnK~DL~~~~~~~~~~~~~-----~~r~Vs~eeg~~~a~~~~~~~f~EtSAkt~~~V~e~F~~~i 170 (174) T cd04135 105 --------VPYLLVGTQIDLRDDPKTLARLNDM-----KEKPVTVEQGQKLAKEIGAHCYVECSALTQKGLKTVFDEAI 170 (174) T ss_pred --------CEEEEEECCCCCCCCHHHHHHHHHC-----CCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH T ss_conf --------5489973563331214677665420-----26778989999999980892468874146777789999999 No 62 >cd04156 ARLTS1 ARLTS1 subfamily. ARLTS1 (Arf-like tumor suppressor gene 1), also known as Arl11, is a member of the Arf family of small GTPases that is believed to play a major role in apoptotic signaling. ARLTS1 is widely expressed and functions as a tumor suppressor gene in several human cancers. ARLTS1 is a low-penetrance suppressor that accounts for a small percentage of familial melanoma or familial chronic lymphocytic leukemia (CLL). ARLTS1 inactivation seems to occur most frequently through biallelic down-regulation by hypermethylation of the promoter. In breast cancer, ARLTS1 alterations were typically a combination of a hypomorphic polymorphism plus loss of heterozygosity. In a case of thyroid adenoma, ARLTS1 alterations were polymorphism plus promoter hypermethylation. The nonsense polymorphism Trp149Stop occurs with significantly greater frequency in familial cancer cases than in sporadic cancer cases, and the Cys148Arg polymorphism is associated with an increase in h Probab=98.59 E-value=1.5e-07 Score=67.96 Aligned_columns=156 Identities=25% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) ||++|..++|||||+.++..-+-...--..+|..-.+.-+ ...++++|-+.|..-+.++.+.-..--. .+|+| T Consensus 2 IlilG~~~sGKTsll~rl~~~~~~~~~pTig~~~~~~~~~---~~v~l~iwD~~G~e~~r~~~~~y~~~a~----~iI~V 74 (160) T cd04156 2 VLLLGLDSAGKSTLLYKLKHAELVTTIPTVGFNVEMLQLE---KHLSLTVWDVGGQEKMRTVWKCYLENTD----GLVYV 74 (160) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCEEEEECEEEEEEEEC---CEEEEEEEECCCCHHHHHHHHHHCCCCC----EEEEE T ss_conf 7899508986899888774586230220001048899876---8379998745874034666676405763----79999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) +|.+.+-.+-+....|-.+|++.-.+ T Consensus 75 ~D~sd~~~~~~~~~~l~~~l~~~~~~------------------------------------------------------ 100 (160) T cd04156 75 VDSSDEARLDESQKELKHILKNEHIK------------------------------------------------------ 100 (160) T ss_pred EECCCHHHHHHHHHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 72578346899999999885200127------------------------------------------------------ Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHH Q ss_conf 62300588327998507412555542057747899999999999999718768883266367899999999 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYI 300 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl 300 (523) ++|++||++|+|.-..+..+ +-++ ...+.++|-.++--++.||++...|++-+.+.| T Consensus 101 -------~~p~liv~NK~Dl~~~~~~~-ei~~------~l~l~~~~~~~~~~i~~~SA~tG~gi~e~F~~l 157 (160) T cd04156 101 -------GVPVVLLANKQDLPGALTAE-EITR------RFKLKKYCSDRDWYVQPCSAVTGEGLAEAFRKL 157 (160) T ss_pred -------CCEEEEEEECCCCCCCCCHH-HHHH------HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHH T ss_conf -------97599996055885457889-9998------998999986089389997314685778999998 No 63 >cd04143 Rhes_like Rhes_like subfamily. This subfamily includes Rhes (Ras homolog enriched in striatum) and Dexras1/AGS1 (activator of G-protein signaling 1). These proteins are homologous, but exhibit significant differences in tissue distribution and subcellular localization. Rhes is found primarily in the striatum of the brain, but is also expressed in other areas of the brain, such as the cerebral cortex, hippocampus, inferior colliculus, and cerebellum. Rhes expression is controlled by thyroid hormones. In rat PC12 cells, Rhes is farnesylated and localizes to the plasma membrane. Rhes binds and activates PI3K, and plays a role in coupling serpentine membrane receptors with heterotrimeric G-protein signaling. Rhes has recently been shown to be reduced under conditions of dopamine supersensitivity and may play a role in determining dopamine receptor sensitivity. Dexras1/AGS1 is a dexamethasone-induced Ras protein that is expressed primarily in the brain, with low expression l Probab=98.58 E-value=1.7e-07 Score=67.56 Aligned_columns=163 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCC-CCCCCCHHHHHHHHH Q ss_conf 8897369976789999974201468886521456404500004325246368658624324555-678700266645565 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLK-FSLDAVSLKDTLVML 148 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK-~aLt~~si~~TLVvI 148 (523) |++||+.++|||+|+.++..-+-...-..----|..-.-.-....-.+.+|=-.|...+..|.+ +..+.+ .++| T Consensus 3 IVllGd~~VGKTSLi~Rf~~~~F~e~y~pTI~df~~K~i~idg~~v~L~IwDTAGqE~f~sl~~~~~~~ad-----~~IL 77 (247) T cd04143 3 MVVLGASKVGKTAIVSRFLGGRFEEQYTPTIEDFHRKLYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGD-----VFIL 77 (247) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCCCCEEEEEEEECCEEEEEEEECCCCCCCCCCCCCCCCCCCC-----EEEE T ss_conf 89982698318889887653832676234210005789988792899997225446545543402103887-----8999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |-|.+.+.+| +.++.|.+.+++.-..+. ...++ T Consensus 78 VyDIT~r~SF-e~v~~w~~eI~e~k~~~~---~~~~~------------------------------------------- 110 (247) T cd04143 78 VFSLDNRESF-EEVCRLREQILETKSCLK---NKTKE------------------------------------------- 110 (247) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHHHHHC---CCCCC------------------------------------------- T ss_conf 9756997899-999999999998631100---23457------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHH-HHHHCCEEEEECCCCHHHHHHHHHHHH Q ss_conf 7623005883279985074125555420577478999999999999-997187688832663678999999999 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKF-CLRYGAALIYTSVKENKNIDLVYKYIV 301 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~i-cL~YGAaLiYTS~ke~knl~LLykYl~ 301 (523) |-.+|+++|.+|+|. +++..+-..-...+ +-++|+..|-||+|.+.|++-+.+-|. T Consensus 111 ------~~~vpiILVGNK~DL-----------~~~R~Vs~eEa~q~~A~~~~~~ffEtSAKtg~NVdE~F~~L~ 167 (247) T cd04143 111 ------NVKIPMVICGNKADR-----------DFPREVQRDEVEQLVGGDENCAYFEVSAKKNSNLDEMFRALF 167 (247) T ss_pred ------CCCCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH T ss_conf ------887279997055673-----------225733889999999982798289985258988899999999 No 64 >cd04147 Ras_dva Ras-dva subfamily. Ras-dva (Ras - dorsal-ventral anterior localization) subfamily consists of a set of proteins characterized only in Xenopus leavis, to date. In Xenopus Ras-dva expression is activated by the transcription factor Otx2 and begins during gastrulation throughout the anterior ectoderm. Ras-dva expression is inhibited in the anterior neural plate by factor Xanf1. Downregulation of Ras-dva results in head development abnormalities through the inhibition of several regulators of the anterior neural plate and folds patterning, including Otx2, BF-1, Xag2, Pax6, Slug, and Sox9. Downregulation of Ras-dva also interferes with the FGF-8a signaling within the anterior ectoderm. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Probab=98.57 E-value=2.1e-07 Score=66.99 Aligned_columns=174 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |++||+.++|||+|+.++.. .+++...-+ ++....+.-+++ .-.+.+|=-.|...+..|.+.-..--+ .+ T Consensus 2 IvllGd~~VGKTsLi~rf~~~~F~~~y~~Ti~-~~~~k~~~v~~~--~v~l~iwDTaGqe~f~~l~~~~~r~a~----~~ 74 (198) T cd04147 2 LVFMGAAGVGKTALIQRFLYDTFEPKYRRTVE-EMHRKEYEVGGV--SLTLDILDTSGSYSFPAMRKLSIQNSD----AF 74 (198) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCC-CCEEEEEEECCE--EEEEEEECCCCHHHHHHHHHHHHCCCC----CE T ss_conf 78881798328999988761810775232200-104678988896--899997328770332347677623788----07 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) |||-|.+.+.+|- .++.|...+.+.-..-.+ T Consensus 75 ilVyDit~~~SF~-~v~~w~~~i~~~~~~~~~------------------------------------------------ 105 (198) T cd04147 75 ALVYAVDDPESFE-EVERLREEILEVKEDKFV------------------------------------------------ 105 (198) T ss_pred EEEEECCCHHHHH-HHHHHHHHHHHHCCCCCC------------------------------------------------ T ss_conf 9998647977899-999999999985189998------------------------------------------------ Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHH-HHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 88762300588327998507412555542057747899999999999999-71876888326636789999999998760 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCL-RYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL-~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) |+++|.+|+|..+ ++..+-..--+.+|- .||+..|-||+|.+.|++-+...|+-.++ T Consensus 106 ------------pivLVGNK~Dll~----------~~R~V~~~e~~~~a~~~~~~~f~EtSAk~g~nV~e~F~~l~rei~ 163 (198) T cd04147 106 ------------PIVVVGNKADSLE----------EERQVPAKDALSTVELDWNCGFVETSAKDNENVLEVFKELLRQAN 163 (198) T ss_pred ------------EEEEEECCCCCCC----------CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ------------8999722676622----------167467899999999847993899851478887899999999740 Q ss_pred CCCCCCCCCCCCCCEE Q ss_conf 6555655641136402 Q Ver_Hs_NP_0572 306 GFPYKIPAVVVEKDAV 321 (523) Q Consensus 306 gfpf~~~a~ViDrD~I 321 (523) .---+.|+.-.-+.++ T Consensus 164 ~~~~~~~~~~~~~~~~ 179 (198) T cd04147 164 LPYNLSPALRRRRESL 179 (198) T ss_pred HHHHCCCCHHHHCCCC T ss_conf 0421580023102468 No 65 >cd04129 Rho2 Rho2 subfamily. Rho2 is a fungal GTPase that plays a role in cell morphogenesis, control of cell wall integrity, control of growth polarity, and maintenance of growth direction. Rho2 activates the protein kinase C homolog Pck2, and Pck2 controls Mok1, the major (1-3) alpha-D-glucan synthase. Together with Rho1 (RhoA), Rho2 regulates the construction of the cell wall. Unlike Rho1, Rho2 is not an essential protein, but its overexpression is lethal. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for proper intracellular localization via membrane attachment. As with other Rho family GTPases, the GDP/GTP cycling is regulated by GEFs (guanine nucleotide exchange factors), GAPs (GTPase-activating proteins) and GDIs (guanine nucleotide dissociation inhibitors). Probab=98.55 E-value=3.4e-07 Score=65.57 Aligned_columns=176 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |++||+.++|||+|+.++..-.-...-...-+..+-..=.-.+..-++.+|=..|...+..|.+.....-+ .++|| T Consensus 4 ivliGd~~VGKTsL~~r~~~~~F~~~~~pTi~~~~~~~i~v~~~~v~l~iwDTaGqe~~~~l~~~~~~~a~----~~ilv 79 (187) T cd04129 4 LVIVGDGACGKTSLLSVFTLGEFPEEYHPTVFENYVTDCRVDGKPVQLALWDTAGQEEYERLRPLSYSKAH----VILIG 79 (187) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHHCCCC----EEEEE T ss_conf 89982598438999999861732776366036656774467786899988655765215789998706997----89999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.|.++..=-++|+..++.+..+ T Consensus 80 ydi~~~~Sf~~i~~~w~~~~~~~~~~------------------------------------------------------ 105 (187) T cd04129 80 FAVDTPDSLENVRTKWIEEVRRYCPN------------------------------------------------------ 105 (187) T ss_pred EECCCHHHHHHHHHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 63388567888889889999983689------------------------------------------------------ Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC-EEEEECCCCHHHHHHHHHHHHHHHCCCC Q ss_conf 623005883279985074125555420577478999999999999997187-6888326636789999999998760655 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGA-ALIYTSVKENKNIDLVYKYIVQKLYGFP 308 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGA-aLiYTS~ke~knl~LLykYl~HrLygfp 308 (523) +|+++|.+|+|.-+.-........ +..+-.+-.+.+|-+.|+ ..|-||+|...|++-+...+.-.....+ T Consensus 106 --------~piiLvGnK~DL~~~~~~~~~~~~-~r~v~~~e~~~~a~~~~~~~y~EtSAktg~nV~e~Fe~~~r~aL~~~ 176 (187) T cd04129 106 --------VPVILVGLKKDLRQDAVAKEEYRT-QRFVPIQQGKRVAKEIGAKKYMECSALTGEGVDDVFEAATRAALLVR 176 (187) T ss_pred --------CEEEEEECCCCCHHHHHHHHHHHH-CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC T ss_conf --------449998358871123443210111-05689899999999728954788633578787899999999984576 Q ss_pred CCCC Q ss_conf 5655 Q Ver_Hs_NP_0572 309 YKIP 312 (523) Q Consensus 309 f~~~ 312 (523) -+.+ T Consensus 177 ~~~~ 180 (187) T cd04129 177 KSEP 180 (187) T ss_pred CCCC T ss_conf 7888 No 66 >cd04126 Rab20 Rab20 subfamily. Rab20 is one of several Rab proteins that appear to be restricted in expression to the apical domain of murine polarized epithelial cells. It is expressed on the apical side of polarized kidney tubule and intestinal epithelial cells, and in non-polarized cells. It also localizes to vesico-tubular structures below the apical brush border of renal proximal tubule cells and in the apical region of duodenal epithelial cells. Rab20 has also been shown to colocalize with vacuolar H+-ATPases (V-ATPases) in mouse kidney cells, suggesting a role in the regulation of V-ATPase traffic in specific portions of the nephron. It was also shown to be one of several proteins whose expression is upregulated in human myelodysplastic syndrome (MDS) patients. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bo Probab=98.55 E-value=2.8e-07 Score=66.11 Aligned_columns=164 Identities=25% Q ss_pred EEEEECCCCCHHHHHHHHHH--CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHH Q ss_conf 88973699767899999742--0146888652145640450000432524636865862432455567870026664556 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG--IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVM 147 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~--~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVv 147 (523) |++||+.++|||+|+.|+.. ..++...-+.+|..-+...-+ +.+|=..|...+.+|.+.-..--. .+| T Consensus 3 ivliGd~~VGKTsLi~r~~~~~F~~~~~Tig~~~~~k~~~~~~------l~IWDTAGqE~f~~l~~~yyr~a~----~~i 72 (220) T cd04126 3 VVLLGDMNVGKTSLLHRYMERRFKDTVSTVGGAFYLKQWGPYN------ISIWDTAGREQFHGLGSMYCRGAA----AVI 72 (220) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEEE------EEEEECCCCHHHHHHHHHHCCCCC----EEE T ss_conf 8998079832899988876371057546223568887224799------999754762354567786505897----899 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 55401013689999999999999999732789889999999999999985045556666553445676667765344788 Q Ver_Hs_NP_0572 148 LVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPL 227 (523) Q Consensus 148 IvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPL 227 (523) ||-|.+.+-+| +.++.|+.-+++.... T Consensus 73 lVyDit~~~SF-~~i~~~~~~~~~~~~~---------------------------------------------------- 99 (220) T cd04126 73 LTYDVSNVQSL-EELEDRFLGLTDTANE---------------------------------------------------- 99 (220) T ss_pred EEEECCCHHHH-HHHHHHHHHHHHHCCC---------------------------------------------------- T ss_conf 99766997788-9999999999983499---------------------------------------------------- Q ss_pred CCCCCCCCCCCCEEEEEECCCHHH--------HHHHCCCCCHHHHHHHHHHHHHHHHHHCCE--------------EEEE Q ss_conf 876230058832799850741255--------554205774789999999999999971876--------------8883 Q Ver_Hs_NP_0572 228 GADTLTHNLGIPVLVVCTKCDAIS--------VLEKEHDYRDEHFDFFQSHIRKFCLRYGAA--------------LIYT 285 (523) Q Consensus 228 geg~Lt~NLGiPivVVctKsD~ie--------~LEKe~~y~dE~fDfIqq~LR~icL~YGAa--------------LiYT 285 (523) -+|+++|.+|+|..+ ..+..+-..+.+..+=..-.+.||-+++.- .|.| T Consensus 100 ---------~~~iilvGNK~DL~~~~~~~~~~~~~~~~~~~e~~r~V~~ee~~~~a~~~~~~~~~~~~~~~~~~~~y~Et 170 (220) T cd04126 100 ---------DCLFAVVGNKLDLTEEGALAGQEKDAGDRVSPEDQRQVTLEDAKAFYKRINKYKMLDEDLSPAAEKMCFET 170 (220) T ss_pred ---------CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCEEEE T ss_conf ---------95899971463422222112222111111231000456789999999985221000000001037536897 Q ss_pred CCCCHHHHHHHHHHHHHHHC Q ss_conf 26636789999999998760 Q Ver_Hs_NP_0572 286 SVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 286 S~ke~knl~LLykYl~HrLy 305 (523) |+|...|++-+..+|.-+.+ T Consensus 171 SAKtg~nV~e~F~~l~~~vl 190 (220) T cd04126 171 SAKTGYNVDELFEYLFNLVL 190 (220) T ss_pred ECCCCCCHHHHHHHHHHHHH T ss_conf 51578788899999999999 No 67 >cd04176 Rap2 Rap2 subgroup. The Rap2 subgroup is part of the Rap subfamily of the Ras family. It consists of Rap2a, Rap2b, and Rap2c. Both isoform 3 of the human mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) and Traf2- and Nck-interacting kinase (TNIK) are putative effectors of Rap2 in mediating the activation of c-Jun N-terminal kinase (JNK) to regulate the actin cytoskeleton. In human platelets, Rap2 was shown to interact with the cytoskeleton by binding the actin filaments. In embryonic Xenopus development, Rap2 is necessary for the Wnt/beta-catenin signaling pathway. The Rap2 interacting protein 9 (RPIP9) is highly expressed in human breast carcinomas and correlates with a poor prognosis, suggesting a role for Rap2 in breast cancer oncogenesis. Rap2b, but not Rap2a, Rap2c, Rap1a, or Rap1b, is expressed in human red blood cells, where it is believed to be involved in vesiculation. A number of additional effector proteins for Rap2 have been identified, incl Probab=98.53 E-value=3e-07 Score=65.95 Aligned_columns=159 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+||.++..-+-...-...---+..-.=.-....-.+.+|=..|...+..|.+.-..--+ .++|| T Consensus 4 IvvvGd~~VGKTsli~rf~~~~f~~~y~~Ti~~~~~k~i~~~~~~~~l~i~Dt~G~e~~~~~~~~~~~~a~----~~ilv 79 (163) T cd04176 4 VVVLGSGGVGKSALTVQFVSGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQ----GFIVV 79 (163) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCCCCEEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCCCC----EEEEE T ss_conf 89970798548999988763800776563100004789988896899998746887124567774257998----69999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+.++-. ++.|..-+...-..-.+ T Consensus 80 ydi~~~~Sf~~-i~~~~~~i~~~~~~~~~--------------------------------------------------- 107 (163) T cd04176 80 YSLVNQQTFQD-IKPMRDQIVRVKGYEKV--------------------------------------------------- 107 (163) T ss_pred EECCCHHHHHH-HHHHHHHHHHHCCCCCC--------------------------------------------------- T ss_conf 76699768899-99987656753189982--------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) |+++|.+|+|. +++..+-.+-.+.|+-++|+..|.||+|.+.|++-+...|..++ T Consensus 108 ---------piilvGnK~Dl-----------~~~r~V~~~e~~~~a~~~~~~y~E~SAk~~~nV~e~F~~l~~~i 162 (163) T cd04176 108 ---------PIILVGNKVDL-----------ESEREVSSAEGRALAEEWGCPFMETSAKSKTMVNELFAEIVRQM 162 (163) T ss_pred ---------EEEEEECCCCH-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC T ss_conf ---------89997332001-----------11102463789999996399589997047988789999999861 No 68 >cd04151 Arl1 Arl1 subfamily. Arl1 (Arf-like 1) localizes to the Golgi complex, where it is believed to recruit effector proteins to the trans-Golgi network. Like most members of the Arf family, Arl1 is myristoylated at its N-terminal helix and mutation of the myristoylation site disrupts Golgi targeting. In humans, the Golgi-localized proteins golgin-97 and golgin-245 have been identified as Arl1 effectors. Golgins are large coiled-coil proteins found in the Golgi, and these golgins contain a C-terminal GRIP domain, which is the site of Arl1 binding. Additional Arl1 effectors include the GARP (Golgi-associated retrograde protein)/VFT (Vps53) vesicle-tethering complex and Arfaptin 2. Arl1 is not required for exocytosis, but appears necessary for trafficking from the endosomes to the Golgi. In Drosophila zygotes, mutation of Arl1 is lethal, and in the host-bloodstream form of Trypanosoma brucei, Arl1 is essential for viability. Probab=98.53 E-value=5.1e-07 Score=64.43 Aligned_columns=155 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) ||+||..++|||||+.++..-+-...---.++.+-.+.-++ ..+++|-+.|...+.++-+.-..--+ .|++| T Consensus 2 ililG~~~~GKTsii~r~~~~~~~~~~pT~g~~~~~i~~~~----~~~~iwD~~Gqe~~r~~~~~y~~~a~----~iI~V 73 (158) T cd04151 2 ILILGLDNAGKTTILYRLQLGEVVTTIPTIGFNVETVTYKN----LKFQVWDLGGQTSIRPYWRCYYSNTD----AIIYV 73 (158) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECC----EEEEEEECCCCCCCCHHHHHHCCCCC----EEEEE T ss_conf 78895089868887776643862120032001588986178----18999754887434213564403778----79999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) +|.+..-.+-+....|..++++.-.. T Consensus 74 ~D~sd~~~~~~~~~~l~~~l~~~~~~------------------------------------------------------ 99 (158) T cd04151 74 VDSTDRDRLGTAKEELHAMLEEEELK------------------------------------------------------ 99 (158) T ss_pred EECCCHHHHHHHHHHHHHHHHCCCCC------------------------------------------------------ T ss_conf 84588346899999999997200447------------------------------------------------------ Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH Q ss_conf 623005883279985074125555420577478999999999999997187688832663678999999999 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIV 301 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~ 301 (523) ++|++|+++|+|.-..+..+ ++.+..--..+-++...++.||++...+++-..+.|. T Consensus 100 -------~~pilIl~NK~Dl~~~~~~~--------~i~~~~~l~~~~~~~~~~~~~SA~tg~Gi~e~f~wL~ 156 (158) T cd04151 100 -------GAVLLVFANKQDMPGALSEA--------EISEKLGLSELKDRTWSIFKTSAIKGEGLDEGMDWLV 156 (158) T ss_pred -------CCEEEEEEECCCCCCCCCHH--------HHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHH T ss_conf -------98899995067862137988--------9999986788713882899874136988899999862 No 69 >cd04144 Ras2 Ras2 subfamily. The Ras2 subfamily, found exclusively in fungi, was first identified in Ustilago maydis. In U. maydis, Ras2 is regulated by Sql2, a protein that is homologous to GEFs (guanine nucleotide exchange factors) of the CDC25 family. Ras2 has been shown to induce filamentous growth, but the signaling cascade through which Ras2 and Sql2 regulate cell morphology is not known. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Probab=98.52 E-value=4.4e-07 Score=64.85 Aligned_columns=158 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+.+...-+-.|.-.-+.+ +..-.+.+|=-.|...+..|.+.-+.--+ .+ T Consensus 2 ivliGd~gVGKTsLi~rf~~~~F~~~y~pTi~~~~~~~~~i~---~~~~~l~iwDTaGqe~~~~l~~~~~r~a~----~~ 74 (190) T cd04144 2 LVVLGDGGVGKTALTIQLCLNHFVETYDPTIEDSYRKQVVVD---GQPCMLEVLDTAGQEEYTALRDQWIREGE----GF 74 (190) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEC---CEEEEEEEEECCCCCHHHHHHHHHHCCCC----EE T ss_conf 788817984289999998708107764664011147889871---54799999747986024688787530560----78 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+-+|-. ++.|+..+..+-.... T Consensus 75 ilVyditd~~SF~~-i~~w~~~i~~~~~~~~------------------------------------------------- 104 (190) T cd04144 75 ILVYSITSRSTFER-VERFREQIQRVKDESA------------------------------------------------- 104 (190) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHHHHCC------------------------------------------------- T ss_conf 99987599778999-9999999998742069------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 887623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) -.+|+++|.+|+|.. ++..+-.+--+.+|-++|+..|.||++.+.|++-+...|...+ T Consensus 105 ---------~~~piilVGNK~DL~-----------~~r~V~~ee~~~~a~~~~~~y~E~SAk~~~nV~e~F~~l~~~i 162 (190) T cd04144 105 ---------ADVPIMIVGNKCDKV-----------YEREVSTEEGAALARRLGCEFIEASAKTNVNVERAFYTLVRAL 162 (190) T ss_pred ---------CCCEEEEEECCCCCC-----------CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH T ss_conf ---------997899970565333-----------4466798999999996699199986158988789999999999 No 70 >cd04131 Rnd Rnd subfamily. The Rnd subfamily contains Rnd1/Rho6, Rnd2/Rho7, and Rnd3/RhoE/Rho8. These novel Rho family proteins have substantial structural differences compared to other Rho members, including N- and C-terminal extensions relative to other Rhos. Rnd3/RhoE is farnesylated at the C-terminal prenylation site, unlike most other Rho proteins that are geranylgeranylated. In addition, Rnd members are unable to hydrolyze GTP and are resistant to GAP activity. They are believed to exist only in the GTP-bound conformation, and are antagonists of RhoA activity. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. Probab=98.52 E-value=1.8e-07 Score=67.42 Aligned_columns=166 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.++..-+-...-...-+..+...=+-.+..-.+.+|=..|...+..|.+....--+ .++|| T Consensus 4 ivlvGd~~VGKTsli~r~~~~~F~~~~~~Ti~~~~~~~~~v~~~~v~l~iWDTaGqe~f~~l~~~~y~~a~----~~ilv 79 (178) T cd04131 4 IVVVGDVQCGKTALLQVFAKDCYPETYVPTVFENYTASFEIDEQRIELSLWDTSGSPYYDNVRPLCYPDSD----AVLIC 79 (178) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCCCC----EEEEE T ss_conf 89982698448999999753833766241366457899988684899998756888033557687627996----79999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|++.|-++-.=++.|+.-++++..+ T Consensus 80 fdit~~~Sf~~v~~~W~~ei~~~~~~------------------------------------------------------ 105 (178) T cd04131 80 FDISRPETLDSVLKKWRGEIQEFCPN------------------------------------------------------ 105 (178) T ss_pred EECCCHHHHHHHHHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 75688557789999999999984598------------------------------------------------------ Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHH-HHHHHHHHHHHHHHHHCCEEEE-ECCCCHHH-HHHHHHHHH Q ss_conf 623005883279985074125555420577478-9999999999999971876888-32663678-999999999 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDE-HFDFFQSHIRKFCLRYGAALIY-TSVKENKN-IDLVYKYIV 301 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE-~fDfIqq~LR~icL~YGAaLiY-TS~ke~kn-l~LLykYl~ 301 (523) +|+++|.+|+|..+-+..-....++ +..+-..--+.++-++||-++| ||++...| ++=+..+.. T Consensus 106 --------~~iiLVGnK~DLr~~~~~~~~l~~~~~~~Vs~eeg~~~A~~~~a~~y~E~SAktg~ngV~evF~~a~ 172 (178) T cd04131 106 --------TKVLLVGCKTDLRTDLSTLMELSHQRQAPVSYEQGCAIAKQLGAEIYLECSAFTSEKSVRDIFHVAT 172 (178) T ss_pred --------CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHH T ss_conf --------5399960421221215678887635787789899999999829925775301115678789999999 No 71 >cd01875 RhoG RhoG subfamily. RhoG is a GTPase with high sequence similarity to members of the Rac subfamily, including the regions involved in effector recognition and binding. However, RhoG does not bind to known Rac1 and Cdc42 effectors, including proteins containing a Cdc42/Rac interacting binding (CRIB) motif. Instead, RhoG interacts directly with Elmo, an upstream regulator of Rac1, in a GTP-dependent manner and forms a ternary complex with Dock180 to induce activation of Rac1. The RhoG-Elmo-Dock180 pathway is required for activation of Rac1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Thus RhoG activates Rac1 through Elmo and Dock180 to control cell morphology. RhoG has also been shown to play a role in caveolar trafficking and has a novel role in signaling the neutrophil respiratory burst stimulated by G protein-coupled receptor (GPCR) agonists. Most Rho proteins contain a lipid modification site at the C-termin Probab=98.51 E-value=3.4e-07 Score=65.61 Aligned_columns=173 Identities=15% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.++..-.-..+-..--...+..+-.-.+..-.+.+|=-.|...+..|.+....--+. +||| T Consensus 6 vvliGd~~VGKTsli~r~~~~~F~~~~~pTi~~~~~~~~~~~~~~v~l~iwDTaGqe~~~~l~~~~~~~a~~----~iiv 81 (191) T cd01875 6 CVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQTAVDGRTVSLNLWDTAGQEEYDRLRTLSYPQTNV----FIIC 81 (191) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCCE----EEEE T ss_conf 998707984289998887528426653550455468866651727999851488854467787876238986----9999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+++|-.=-+.|+.-++.+. T Consensus 82 yditd~~Sf~~i~~~w~~~i~~~~-------------------------------------------------------- 105 (191) T cd01875 82 FSIASPSSYENVRHKWHPEVCHHC-------------------------------------------------------- 105 (191) T ss_pred EECCCHHHHHHHHHHHHHHHHHHC-------------------------------------------------------- T ss_conf 864886788999998899999726-------------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHH-HHHHHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHHHHHCCC Q ss_conf 623005883279985074125555420577478-9999999999999971876888-32663678999999999876065 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDE-HFDFFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYKYIVQKLYGF 307 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE-~fDfIqq~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~HrLygf 307 (523) -.+|+++|.+|+|....-+-.....|+ +..+-.+--+.+|-++|+-.+| ||+|...|++-+...+.-.+... T Consensus 106 ------~~vpiiLVGNK~DL~~~~~~~~~~~e~~~~~Vs~eeg~~~a~~~~~~~y~EtSAktg~nV~e~F~~l~r~vl~~ 179 (191) T cd01875 106 ------PNVPILLVGTKKDLRNDADTLKKLKEQGQAPITPQQGGALAKQIHAVKYLECSALNQDGVKEVFAEAVRAVLNP 179 (191) T ss_pred ------CCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC T ss_conf ------89679998347663112688888875102466889999999980895068864047778789999999998478 Q ss_pred C Q ss_conf 5 Q Ver_Hs_NP_0572 308 P 308 (523) Q Consensus 308 p 308 (523) . T Consensus 180 ~ 180 (191) T cd01875 180 T 180 (191) T ss_pred C T ss_conf 8 No 72 >cd01893 Miro1 Miro1 subfamily. Miro (mitochondrial Rho) proteins have tandem GTP-binding domains separated by a linker region containing putative calcium-binding EF hand motifs. Genes encoding Miro-like proteins were found in several eukaryotic organisms. This CD represents the N-terminal GTPase domain of Miro proteins. These atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. Most Rho proteins contain a lipid modification site at the C-terminus; however, Miro is one of few Rho subfamilies that lack this feature. Probab=98.50 E-value=6.4e-07 Score=63.80 Aligned_columns=152 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHH Q ss_conf 88973699767899999742---014688865214564045000043252463686586243245556787002666455 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLV 146 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLV 146 (523) |+++|+.++|||+|+.++.. .+++.....--..-.++.+++. .+.+|=..|...+..+...-+.--+ .+ T Consensus 3 ivliGd~~VGKTsL~~rf~~~~F~~~~~~t~~~~~~~~~~~~~~v----~l~iwDtagqe~~~~~~~~~~~~a~----~~ 74 (166) T cd01893 3 IVLIGDEGVGKSSLIMSLVSEEFPENVPRVLPEITIPADVTPERV----PTTIVDTSSRPQDRANLAAEIRKAN----VI 74 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCEEEEEEEEEECCCEE----EEEEEECCCCCCCHHHHHHHHCCCC----EE T ss_conf 899807983388998887548006665651035799899718568----9999872588750566787613898----89 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 65540101368999999999999999973278988999999999999998504555666655344567666776534478 Q Ver_Hs_NP_0572 147 MLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVP 226 (523) Q Consensus 147 vIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lP 226 (523) +||-|.+.+.++-.=...|+..++ T Consensus 75 iivydi~~~~Sf~~i~~~W~~~i~-------------------------------------------------------- 98 (166) T cd01893 75 CLVYSVDRPSTLERIRTKWLPLIR-------------------------------------------------------- 98 (166) T ss_pred EEEEECCCHHHHHHHHHHHHHHHH-------------------------------------------------------- T ss_conf 999864886787889988799997-------------------------------------------------------- Q ss_pred CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCE--EEEECCCCHHHHHHHHHHH Q ss_conf 8876230058832799850741255554205774789999999999999971876--8883266367899999999 Q Ver_Hs_NP_0572 227 LGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAA--LIYTSVKENKNIDLVYKYI 300 (523) Q Consensus 227 Lgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAa--LiYTS~ke~knl~LLykYl 300 (523) ....| +|+++|.+|+|..+ +++-....+-+-.++-.|... -|-||+|.+.|++-+..|. T Consensus 99 ----~~~~~--~piilVGNK~DL~~---------~~~~~~~e~~~~~~~~~~~~i~~~~EtSAkt~~nV~e~F~~a 159 (166) T cd01893 99 ----RLGVK--VPIILVGNKSDLRD---------GSSQAGLEEEMLPIMNEFREIETCVECSAKTLINVSEVFYYA 159 (166) T ss_pred ----HHCCC--CEEEEEECCCCCCC---------CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHH T ss_conf ----51689--57999715764223---------542101478999999974277507887503688878999999 No 73 >cd01874 Cdc42 Cdc42 subfamily. Cdc42 is an essential GTPase that belongs to the Rho family of Ras-like GTPases. These proteins act as molecular switches by responding to exogenous and/or endogenous signals and relaying those signals to activate downstream components of a biological pathway. Cdc42 transduces signals to the actin cytoskeleton to initiate and maintain polarized growth and to mitogen-activated protein morphogenesis. In the budding yeast Saccharomyces cerevisiae, Cdc42 plays an important role in multiple actin-dependent morphogenetic events such as bud emergence, mating-projection formation, and pseudohyphal growth. In mammalian cells, Cdc42 regulates a variety of actin-dependent events and induces the JNK/SAPK protein kinase cascade, which leads to the activation of transcription factors within the nucleus. Cdc42 mediates these processes through interactions with a myriad of downstream effectors, whose number and regulation we are just starting to understand. In addi Probab=98.49 E-value=3.8e-07 Score=65.24 Aligned_columns=164 Identities=16% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.++..-.-..+-...-...+.+.-.-.+....+.+|=-.|...+..|.+....--+. +||| T Consensus 4 vvlvGd~~VGKTsli~r~~~~~F~~~~~~Ti~~~~~~~i~i~~~~~~l~iwDTaGqe~~~~l~~~~~r~a~~----~iiv 79 (175) T cd01874 4 CVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDV----FLVC 79 (175) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCCCCE----EEEE T ss_conf 999817983278988886528226652423530167999998958999986367760245666865059987----9999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+.++-.-.++|+.-++.+. T Consensus 80 ydit~~~SF~~i~~~w~~~~~~~~-------------------------------------------------------- 103 (175) T cd01874 80 FSVVSPSSFENVKEKWVPEITHHC-------------------------------------------------------- 103 (175) T ss_pred EECCCHHHHHHHHHHHHHHHHHHC-------------------------------------------------------- T ss_conf 757864248999998899999725-------------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCH---HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHH Q ss_conf 62300588327998507412---55554205774789999999999999971876888-32663678999999999 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDA---ISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYKYIV 301 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~---ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~ 301 (523) -++|+++|.+|+|. -..+|+- ..+++..+-...-++++-++|+-.+| ||+|...|++=+...+. T Consensus 104 ------~~~p~ilVGnK~DL~~~~~~~~~~--~~~~~r~Vs~eeg~~~A~~~~~~~y~EtSAktg~~V~e~F~~ai 171 (175) T cd01874 104 ------PKTPFLLVGTQIDLRDDPSTIEKL--AKNKQKPITPETGEKLARDLKAVKYVECSALTQKGLKNVFDEAI 171 (175) T ss_pred ------CCCEEEEEECCCCCCCCHHHHHHH--HHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH T ss_conf ------896499971675643415788876--52136776889999999972895079875146766789999999 No 74 >smart00176 RAN Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases; Ran is involved in the active transport of proteins through nuclear pores. Probab=98.49 E-value=4.5e-07 Score=64.77 Aligned_columns=154 Identities=24% Q ss_pred EECCCCCHHHHHHHHHH---CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 73699767899999742---014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 73 LGEDGAGKTSLIRKIQG---IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 73 LG~~~sGKTtLl~~Lq~---~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) +|+.++|||+|+.|+.. .+.+...-|.+|....+..++. .-++.+|=..|...+.+|.+.-..--. -++|| T Consensus 1 VGDsgVGKTsli~R~~~~~F~~~y~~TIGvd~~~k~i~~~~~--~I~l~IWDTAGQE~f~sl~~~yyr~a~----g~ilV 74 (200) T smart00176 1 VGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRG--PIKFNVWDTAGQEKFGGLEDGYYIQAQ----CAIIM 74 (200) T ss_pred CCCCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEECCC--EEEEEEEECCCCCCCCCCCHHHHCCCC----EEEEE T ss_conf 988741278887776447006763554666788999987185--799988751565211000212305884----79999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+-++-. |.+|++-+..+-.. T Consensus 75 fDVT~~~SF~n-i~~W~~ei~~~~~~------------------------------------------------------ 99 (200) T smart00176 75 FDVTSRVTYKN-VPNWHRDLVRVCEN------------------------------------------------------ 99 (200) T ss_pred EECCCHHHHHH-HHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 76699778888-98899999986489------------------------------------------------------ Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCC Q ss_conf 6230058832799850741255554205774789999999999999971876888326636789999999998760655 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLYGFP 308 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLygfp 308 (523) +||++|.+|+|. +...+..+-+ .|+-++|...|=||+|.+.|++-..-||.++|.|-| T Consensus 100 --------ipivLvGNK~DL------------~~r~v~~e~~-~fa~~~~~~y~EtSAKt~~NVee~F~~Larkl~~~~ 157 (200) T smart00176 100 --------IPIVLCGNKVDI------------KDRKVKAKSI-VFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDP 157 (200) T ss_pred --------CEEEEEECCCCC------------CCCCCHHHHH-HHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCC T ss_conf --------779998124353------------3243548999-999966895899873478777688999999985488 No 75 >pfam00025 Arf ADP-ribosylation factor family. Pfam combines a number of different Prosite families together Probab=98.49 E-value=4.6e-07 Score=64.74 Aligned_columns=159 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|..++|||||+.++..-+-..----.+|.+..+.-.+ -.+++|-+.|...+.++.+.-..--+. +|+| T Consensus 18 ivllG~~~vGKTsli~r~~~~~~~~~~pTig~~~~~i~~~~----~~~~iwD~~G~e~~r~l~~~y~~~a~~----iI~V 89 (176) T pfam00025 18 ILMLGLDNAGKTTILYKLKLGEVVTTIPTIGFNVETVTYKN----VKFTVWDVGGQESLRPLWRNYFPNTDG----VIFV 89 (176) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCEEEEEEEEEEEEEEECC----EEEEEEECCCCHHHHHHHHHHCCCCCE----EEEE T ss_conf 99984399868898887645830202200311588987658----389998769715689998874125227----9999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) +|.+.+-.+-+....|-.++.+.- T Consensus 90 ~D~sd~~~~~~~~~~l~~ll~~~~-------------------------------------------------------- 113 (176) T pfam00025 90 VDSADRDRIEEAKQELHALLNEEE-------------------------------------------------------- 113 (176) T ss_pred EECCCCCCHHHHHHHHHHHHHCCC-------------------------------------------------------- T ss_conf 964886546899999999850014-------------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) +-.+|++||++|+|.-. ...+++..-+...-+ +|-.+.-.++.||++...+++-...+|...+ T Consensus 114 -----~~~~pilI~~NK~Dl~~------~~~~~ei~~~~~l~~-~~~~~~~~~~~~SAktG~GI~E~f~wL~~~i 176 (176) T pfam00025 114 -----LADAPLLIFANKQDLPG------AMSEAEIRELLGLHE-LRGSRPWEIQGCSAVTGEGLYEGLDWLSNNI 176 (176) T ss_pred -----CCCCEEEEEEECCCCCC------CCCHHHHHHHHHHHH-HHCCCCEEEEEEEECCCCCHHHHHHHHHHCC T ss_conf -----58978999960668877------889899999988898-7238966999875024888899999998309 No 76 >cd04177 RSR1 RSR1 subgroup. RSR1/Bud1p is a member of the Rap subfamily of the Ras family that is found in fungi. In budding yeasts, RSR1 is involved in selecting a site for bud growth on the cell cortex, which directs the establishment of cell polarization. The Rho family GTPase cdc42 and its GEF, cdc24, then establish an axis of polarized growth by organizing the actin cytoskeleton and secretory apparatus at the bud site. It is believed that cdc42 interacts directly with RSR1 in vivo. In filamentous fungi, polar growth occurs at the tips of hypha and at novel growth sites along the extending hypha. In Ashbya gossypii, RSR1 is a key regulator of hyphal growth, localizing at the tip region and regulating in apical polarization of the actin cytoskeleton. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key featu Probab=98.49 E-value=2.5e-07 Score=66.39 Aligned_columns=160 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.|+..-+-...-...--..+.-.=.-....-.+.+|=..|...+.+|.+.-..--+ .++|| T Consensus 4 iiliGd~~VGKTsli~r~~~~~F~~~~~~Ti~~~~~k~i~v~~~~~~l~iwDtaG~e~~~~l~~~~~~~a~----~~ilv 79 (168) T cd04177 4 IVVLGAGGVGKSALTVQFVQNVFIESYDPTIEDSYRKQVEIDGRQCDLEILDTAGTEQFTAMRELYIKSGQ----GFLLV 79 (168) T ss_pred EEEECCCCCCHHHHHHHHHCCEECCCCCCCCCCCEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCCCC----EEEEE T ss_conf 89980799548999998871800676454101103578989896999998727987124568787535998----58999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+-++ +.|+.|..-+..+..+-.+ T Consensus 80 ydit~~~Sf-~~l~~~~~~i~~~~~~~~~--------------------------------------------------- 107 (168) T cd04177 80 YSVTSEASL-NELGELREQVLRIKDSDNV--------------------------------------------------- 107 (168) T ss_pred EECCCHHHH-HHHHHHHHHHHHHCCCCCC--------------------------------------------------- T ss_conf 856997899-9999999999863189995--------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHHHHHC Q ss_conf 6230058832799850741255554205774789999999999999971876888-326636789999999998760 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~HrLy 305 (523) |+++|.+|+|. +++..+-..-.+.+|-++|..-+| ||+|...|++.+...|.-.++ T Consensus 108 ---------piilvGNK~DL-----------~~~r~v~~~e~~~~a~~~~~~~~~E~SAk~g~nV~e~F~~l~~~il 164 (168) T cd04177 108 ---------PMVLVGNKADL-----------EDDRQVSREDGVSLSQQWGNVPFYETSARKRTNVDEVFIDLVRQII 164 (168) T ss_pred ---------EEEEECCCCCC-----------CCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHH T ss_conf ---------89998024784-----------3357689899999999816983588860489887899999999999 No 77 >KOG1673 Ras GTPases [General function prediction only] Probab=98.48 E-value=1.9e-07 Score=67.24 Aligned_columns=194 Identities=27% Q ss_pred HCCCCCCCCCCCEEE-----EEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCC Q ss_conf 414454257876588-----973699767899999742014688865-21456404500004325246368658624324 Q Ver_Hs_NP_0572 57 STRSRSKLPAGKNVL-----LLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKG 130 (523) Q Consensus 57 ~t~~~~klp~~KnIL-----vLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~ 130 (523) +|....-.|+.+|.+ +||+...|||+|+.+-.+-|--..-.- |+.-|.+-.=--|...-.-++|-|.|.-.+.. T Consensus 5 stv~~~~~~a~~n~Vslkv~llGD~qiGKTs~mvkYV~~~~de~~~q~~GvN~mdkt~~i~~t~IsfSIwdlgG~~~~~n 84 (205) T KOG1673 5 STVANNSIPAVSNLVSLKVGLLGDAQIGKTSLMVKYVQNEYDEEYTQTLGVNFMDKTVSIRGTDISFSIWDLGGQREFIN 84 (205) T ss_pred CCCCCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEHHCCCHHHHHHHHCCCEEEEEEEEECEEEEEEEEECCCHHHHHH T ss_conf 64345677741114789987630665461101221110410456788742200000578611079998430353035541 Q ss_pred CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC Q ss_conf 55567870026664556554010136899999999999999997327898899999999999999850455566665534 Q Ver_Hs_NP_0572 131 LLKFSLDAVSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQR 210 (523) Q Consensus 131 LLK~aLt~~si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~ 210 (523) .|+.|-+-.. .|+++.|+++| .-+.++.+|-+-.|..-+. T Consensus 85 ~lPiac~dsv----aIlFmFDLt~r-~TLnSi~~WY~QAr~~Nkt----------------------------------- 124 (205) T KOG1673 85 MLPIACKDSV----AILFMFDLTRR-STLNSIKEWYRQARGLNKT----------------------------------- 124 (205) T ss_pred CCCEEECCCE----EEEEEEECCCH-HHHHHHHHHHHHHCCCCCC----------------------------------- T ss_conf 4761233728----79876415780-2467899999985047864----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCH Q ss_conf 45676667765344788876230058832799850741255554205774789999999999999971876888326636 Q Ver_Hs_NP_0572 211 RNTASQEDKDDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKEN 290 (523) Q Consensus 211 ~~~~~~~~~d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~ 290 (523) -|||+| .||.|.+ -+.-.|.-.-|...-|+++--.-|+|||+|...+ T Consensus 125 --------------------------AiPilv-GTKyD~f------i~lp~e~Q~~I~~qar~YAk~mnAsL~F~Sts~s 171 (205) T KOG1673 125 --------------------------AIPILV-GTKYDLF------IDLPPELQETISRQARKYAKVMNASLFFCSTSHS 171 (205) T ss_pred --------------------------CCEEEE-ECCHHHH------EECCHHHHHHHHHHHHHHHHHHCCCEEEEECCCC T ss_conf --------------------------340576-1552441------0078136899999999888874462467412242 Q ss_pred HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE Q ss_conf 789999999998760655565564113640252 Q Ver_Hs_NP_0572 291 KNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFI 323 (523) Q Consensus 291 knl~LLykYl~HrLygfpf~~~a~ViDrD~IfI 323 (523) .|+.-+.|.++-++|++|.+.+.+..=-|.|+. T Consensus 172 INv~KIFK~vlAklFnL~~ti~~~~~iGdPild 204 (205) T KOG1673 172 INVQKIFKIVLAKLFNLPWTIPEILTIGDPILD 204 (205) T ss_pred CCHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCC T ss_conf 229999999988883572241322025650005 No 78 >cd01895 EngA2 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability. Probab=98.47 E-value=2.6e-06 Score=59.81 Aligned_columns=155 Identities=23% Q ss_pred CCEEEEEECCCCCHHHHHHHHHHCCCC----CCCCCCEEEEEECCCHHCCHHHHCCEEEEC-CCCCCCCCCCCCCCCCHH Q ss_conf 765889736997678999997420146----888652145640450000432524636865-862432455567870026 Q Ver_Hs_NP_0572 67 GKNVLLLGEDGAGKTSLIRKIQGIEEY----KKGRGLEYLYLNVHDEDRDDQTRCNVWILD-GDLYHKGLLKFSLDAVSL 141 (523) Q Consensus 67 ~KnILvLG~~~sGKTtLl~~Lq~~e~~----kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLd-g~~~~~~LLK~aLt~~si 141 (523) +-+|.++|..++|||||+.+|.+.+.. ..|.-.+..+.....+++. +-++| ++..-..=+..-+....+ T Consensus 2 ~i~I~liG~~NvGKStL~N~l~~~~~~~~s~~~gtT~~~~~~~~~~~~~~------~~l~DtpG~~~~~~~~~~~e~~~~ 75 (174) T cd01895 2 PIRIAIIGRPNVGKSSLVNALLGEERVIVSDIAGTTRDSIDVPFEYDGKK------YTLIDTAGIRRKGKVEEGIEKYSV 75 (174) T ss_pred CEEEEEEECCCCCHHHHHHHHHCCCCCEECCCCCCEEEEEEEEEEECCEE------EEEECCCCCCCCCCCCCHHHHHHH T ss_conf 76889983189988899999856763021378972142368999887858------998727664311110000458999 Q ss_pred HHHH--------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC Q ss_conf 6645--------56554010136899999999999999997327898899999999999999850455566665534456 Q Ver_Hs_NP_0572 142 KDTL--------VMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNT 213 (523) Q Consensus 142 ~~TL--------VvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~ 213 (523) ..++ +++++|-++|++ ++=.+|+..++ T Consensus 76 ~~~~~~i~~~divl~viD~~~~~~--~~d~~i~~~l~------------------------------------------- 110 (174) T cd01895 76 LRTLKAIERADVVLLVIDATEGIT--EQDLRIAGLIL------------------------------------------- 110 (174) T ss_pred HHHHHHHHCCCEEEEEECCCCCCC--HHHHHHHHHHH------------------------------------------- T ss_conf 999998622867999843778988--88999999999------------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH-HCCEEEEECCCCHHH Q ss_conf 7666776534478887623005883279985074125555420577478999999999999997-187688832663678 Q Ver_Hs_NP_0572 214 ASQEDKDDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLR-YGAALIYTSVKENKN 292 (523) Q Consensus 214 ~~~~~~d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~-YGAaLiYTS~ke~kn 292 (523) ..|.|+++|.+|+|++ +-+.+.++.+++.++..+-. .+.-.|++|++...+ T Consensus 111 ---------------------~~~~pii~v~NKiDli-------~~~~~~~~~~~~~~~~~~~~~~~~~ii~iSAktG~g 162 (174) T cd01895 111 ---------------------EEGKALVIVVNKWDLV-------EKDSKTMKEFKKEIRRKLPFLDYAPIVFISALTGQG 162 (174) T ss_pred ---------------------HCCCCEEEEEEECCCC-------CCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC T ss_conf ---------------------6489799986401234-------786546899999999872016897668861567998 Q ss_pred HHHHHHHH Q ss_conf 99999999 Q Ver_Hs_NP_0572 293 IDLVYKYI 300 (523) Q Consensus 293 l~LLykYl 300 (523) ++-|...| T Consensus 163 id~L~~~I 170 (174) T cd01895 163 VDKLFDAI 170 (174) T ss_pred HHHHHHHH T ss_conf 88999999 No 79 >cd04154 Arl2 Arl2 subfamily. Arl2 (Arf-like 2) GTPases are members of the Arf family that bind GDP and GTP with very low affinity. Unlike most Arf family proteins, Arl2 is not myristoylated at its N-terminal helix. The protein PDE-delta, first identified in photoreceptor rod cells, binds specifically to Arl2 and is structurally very similar to RhoGDI. Despite the high structural similarity between Arl2 and Rho proteins and between PDE-delta and RhoGDI, the interactions between the GTPases and their effectors are very different. In its GTP bound form, Arl2 interacts with the protein Binder of Arl2 (BART), and the complex is believed to play a role in mitochondrial adenine nucleotide transport. In its GDP bound form, Arl2 interacts with tubulin- folding Cofactor D; this interaction is believed to play a role in regulation of microtubule dynamics that impact the cytoskeleton, cell division, and cytokinesis. Probab=98.44 E-value=9.5e-07 Score=62.65 Aligned_columns=155 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) ||++|..++|||||+.+|..-.-..-.--.+|.+-.+.-++ ..+++|-+.|...+.++-+.-...-+ .||+| T Consensus 17 IliiG~~~~GKTsil~~l~~~~~~~~~pT~G~~~~~i~~~~----~~l~iwD~~Gqe~~r~~~~~y~~~a~----~iI~V 88 (173) T cd04154 17 ILILGLDNAGKTTILKKLLGEDIDTISPTLGFQIKTLEYEG----YKLNIWDVGGQKTLRPYWRNYFESTD----ALIWV 88 (173) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCEEEEEEEEEEEEEECC----EEEEEEECCCCHHHHHHHHHHCCCCC----EEEEE T ss_conf 99995089878998888728954603423521688889858----89999875875036766553124677----79999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) +|.+.+-.+-+....|-.+|.+.... T Consensus 89 vD~sd~~~~~~~~~~l~~ll~~~~~~------------------------------------------------------ 114 (173) T cd04154 89 VDSSDRLRLDDCKRELKELLQEERLA------------------------------------------------------ 114 (173) T ss_pred EECCCCCCHHHHHHHHHHHHCCHHHC------------------------------------------------------ T ss_conf 75388544688999999874023117------------------------------------------------------ Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH Q ss_conf 623005883279985074125555420577478999999999999997187688832663678999999999 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIV 301 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~ 301 (523) ++|++|+++|+|.-. ....|++.-.... ..+-...-.++.||++...+++-..++|+ T Consensus 115 -------~~pilI~~NK~Dl~~------~~~~~ei~~~l~l--~~~~~~~~~i~~~SAktGeGI~e~f~WL~ 171 (173) T cd04154 115 -------GATLLILANKQDLPG------ALSEEEIREALEL--DKISSHHWRIQPCSAVTGEGLLQGIDWLV 171 (173) T ss_pred -------CCEEEEEEECCCCCC------CCCHHHHHHHHHH--HHHCCCCEEEEEEECCCCCCHHHHHHHHH T ss_conf -------968999972558854------5798999999877--86427965899975025888899999974 No 80 >cd04172 Rnd3_RhoE_Rho8 Rnd3/RhoE/Rho8 subfamily. Rnd3/RhoE/Rho8 is a member of the novel Rho subfamily Rnd, together with Rnd1/Rho6 and Rnd2/Rho7. Rnd3/RhoE is known to bind the serine-threonine kinase ROCK I. Unphosphorylated Rnd3/RhoE associates primarily with membranes, but ROCK I-phosphorylated Rnd3/RhoE localizes in the cytosol. Phosphorylation of Rnd3/RhoE correlates with its activity in disrupting RhoA-induced stress fibers and inhibiting Ras-induced fibroblast transformation. In cells that lack stress fibers, such as macrophages and monocytes, Rnd3/RhoE induces a redistribution of actin, causing morphological changes in the cell. In addition, Rnd3/RhoE has been shown to inhibit cell cycle progression in G1 phase at a point upstream of the pRb family pocket protein checkpoint. Rnd3/RhoE has also been shown to inhibit Ras- and Raf-induced fibroblast transformation. In mammary epithelial tumor cells, Rnd3/RhoE regulates the assembly of the apical junction complex and tight Probab=98.42 E-value=6.4e-07 Score=63.78 Aligned_columns=171 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.++..-+=..+-...-+..+...=+-.+..-++.+|=-.|...+..|.+....--+ .++|| T Consensus 8 ivlvGd~~VGKTsli~r~~~~~F~~~~~~Ti~~~~~~~~~i~~~~v~l~iwDTaGqe~~~~l~~~~y~~a~----~~ilv 83 (182) T cd04172 8 IVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSD----AVLIC 83 (182) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCHHHHHHHHHHCCCCC----EEEEE T ss_conf 99983698548899888753801576120577536899988785999998507887456666476526998----79999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|++.+-++-.-+.+|+.-++++-.. T Consensus 84 fdit~~~Sf~~v~~~W~~ei~~~~~~------------------------------------------------------ 109 (182) T cd04172 84 FDISRPETLDSVLKKWKGEIQEFCPN------------------------------------------------------ 109 (182) T ss_pred EECCCHHHHHHHHHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 86588557899999989999984689------------------------------------------------------ Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHH--HHHHHHHHHHHHHCCEEEE-ECCCCHHH-HHHHHHHHHHHHC Q ss_conf 623005883279985074125555420577478999--9999999999971876888-32663678-9999999998760 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFD--FFQSHIRKFCLRYGAALIY-TSVKENKN-IDLVYKYIVQKLY 305 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fD--fIqq~LR~icL~YGAaLiY-TS~ke~kn-l~LLykYl~HrLy 305 (523) +|+++|.+|+|.-+-.+---+..+ +.. +-..--..++-++||..++ ||+++..| ++-+..-..-... T Consensus 110 --------~~iiLVGnK~DL~~~~~~~~~l~~-~~q~~Vs~eeg~~~A~~~~a~~y~EtSAk~~~n~v~~~F~~a~~a~~ 180 (182) T cd04172 110 --------TKMLLVGCKSDLRTDLTTLVELSN-HRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIFHVATLACV 180 (182) T ss_pred --------CEEEEEECCCCCCCHHHHHHHHHH-CCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHH T ss_conf --------669998548765320577876763-46876798999999997189506887512688418999999999971 Q ss_pred CC Q ss_conf 65 Q Ver_Hs_NP_0572 306 GF 307 (523) Q Consensus 306 gf 307 (523) +. T Consensus 181 ~~ 182 (182) T cd04172 181 NK 182 (182) T ss_pred CC T ss_conf 59 No 81 >cd00881 GTP_translation_factor GTP translation factor family. This family consists primarily of translation initiation, elongation, and release factors, which play specific roles in protein translation. In addition, the family includes Snu114p, a component of the U5 small nuclear riboprotein particle which is a component of the spliceosome and is involved in excision of introns, TetM, a tetracycline resistance gene that protects the ribosome from tetracycline binding, and the unusual subfamily CysN/ATPS, which has an unrelated function (ATP sulfurylase) acquired through lateral transfer of the EF1-alpha gene and development of a new function. Probab=98.38 E-value=2.1e-06 Score=60.43 Aligned_columns=159 Identities=25% Q ss_pred EEEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCC------------EEEECCCCCCCCCCCCC Q ss_conf 588973699767899999742014688865-21456404500004325246------------36865862432455567 Q Ver_Hs_NP_0572 69 NVLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCN------------VWILDGDLYHKGLLKFS 135 (523) Q Consensus 69 nILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~------------vWiLdg~~~~~~LLK~a 135 (523) ||-++|..++|||||+.+|.+....-...+ -...+.|...+.|.-.--+. +-++|-+ +|..+.+.. T Consensus 1 Ni~iiGhvd~GKTTL~~~ll~~~~~~~~~~~~~~~~~D~~~~E~~rgiti~~~~~~~~~~~~~~~~iDtP-GH~~f~~~~ 79 (189) T cd00881 1 NVGIAGHVDHGKTTLTERLLYVTGDIERDGTVEETFLDVLKEERERGITIKSGVATFEWPDRRVNFIDTP-GHEDFSSEV 79 (189) T ss_pred CEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHCEEEEEEECCCEEEEEEECC-CCHHHHHHH T ss_conf 9588973488878999999987402334300010000554788886543101236873188189998178-745567766 Q ss_pred CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 87002666455655401013689999999999999999732789889999999999999985045556666553445676 Q Ver_Hs_NP_0572 136 LDAVSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTAS 215 (523) Q Consensus 136 Lt~~si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~ 215 (523) +..-...+..|+++ |-.+. ++.|-++-+..++ T Consensus 80 ~~~~~~~D~~ilvV-da~~G--~~~qt~~~~~~~~--------------------------------------------- 111 (189) T cd00881 80 IRGLSVSDGAILVV-DANEG--VQPQTREHLRIAR--------------------------------------------- 111 (189) T ss_pred HHHCCCCCEEEEEE-CCCCC--CCHHHHHHHHHHH--------------------------------------------- T ss_conf 32000046689998-17776--4414799999999--------------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEE------------- Q ss_conf 6677653447888762300588327998507412555542057747899999999999999718768------------- Q Ver_Hs_NP_0572 216 QEDKDDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAAL------------- 282 (523) Q Consensus 216 ~~~~d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaL------------- 282 (523) ..++|++||++|.|. +.+|.++-+..-++.+.-.||... T Consensus 112 -------------------~~~~~~iiviNKiD~---------~~~~~~~~v~~ei~~~l~~~~~~~~~~~~~~~~~~~p 163 (189) T cd00881 112 -------------------EGGLPIIVAINKIDR---------VGEEDLEEVLREIKELLGLIGFISTKEEGTRNGLLVP 163 (189) T ss_pred -------------------HCCCCEEEEEECCCC---------CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEE T ss_conf -------------------658968999854688---------8830389999999999864133300233203677421 Q ss_pred -EEECCCCHHHHHHHHHHHHHHH Q ss_conf -8832663678999999999876 Q Ver_Hs_NP_0572 283 -IYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 283 -iYTS~ke~knl~LLykYl~HrL 304 (523) +++|++...+++-|...|..++ T Consensus 164 iv~~SA~~G~gi~~Lle~i~~~l 186 (189) T cd00881 164 IVPGSALTGIGVEELLEAIVEHL 186 (189) T ss_pred EEEEECCCCCCHHHHHHHHHHHC T ss_conf 79831446898689999999737 No 82 >cd04145 M_R_Ras_like M-Ras/R-Ras-like subfamily. This subfamily contains R-Ras2/TC21, M-Ras/R-Ras3, and related members of the Ras family. M-Ras is expressed in lympho-hematopoetic cells. It interacts with some of the known Ras effectors, but appears to also have its own effectors. Expression of mutated M-Ras leads to transformation of several types of cell lines, including hematopoietic cells, mammary epithelial cells, and fibroblasts. Overexpression of M-Ras is observed in carcinomas from breast, uterus, thyroid, stomach, colon, kidney, lung, and rectum. In addition, expression of a constitutively active M-Ras mutant in murine bone marrow induces a malignant mast cell leukemia that is distinct from the monocytic leukemia induced by H-Ras. TC21, along with H-Ras, has been shown to regulate the branching morphogenesis of ureteric bud cell branching in mice. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an ali Probab=98.35 E-value=2e-06 Score=60.56 Aligned_columns=162 Identities=17% Q ss_pred CCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHH Q ss_conf 7876588973699767899999742014688865-214564045000043252463686586243245556787002666 Q Ver_Hs_NP_0572 65 PAGKNVLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKD 143 (523) Q Consensus 65 p~~KnILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~ 143 (523) |. =-|+++|+.++|||+|+.++..-+-...-.. ++-.|.. .-.-.+....+.+|-..|...+..+.+....--+ T Consensus 1 p~-~Kiv~iGd~~VGKTsll~r~~~~~f~~~~~pt~~~~~~k-~~~v~~~~~~l~i~Dt~g~e~~~~~~~~~~~~a~--- 75 (164) T cd04145 1 PT-YKLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTK-QCEIDGQWAILDILDTAGQEEFSAMREQYMRTGE--- 75 (164) T ss_pred CC-EEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEE-EEEECCEEEEEEEEECCCCCHHHHHHHHHHCCCC--- T ss_conf 92-789998079954899999987170177657530212788-8988894899988506876001245488723896--- Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 45565540101368999999999999999973278988999999999999998504555666655344567666776534 Q Ver_Hs_NP_0572 144 TLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSV 223 (523) Q Consensus 144 TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v 223 (523) .++||-|++.+ .-.+.+++|+.-+. T Consensus 76 -~~iivydi~~~-~Sf~~i~~w~~~i~----------------------------------------------------- 100 (164) T cd04145 76 -GFLLVFSVTDR-GSFEEVDKFHTQIL----------------------------------------------------- 100 (164) T ss_pred -EEEEEEECCCH-HHHHHHHHHHHHHH----------------------------------------------------- T ss_conf -68999876996-57899999988777----------------------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHH Q ss_conf 47888762300588327998507412555542057747899999999999999718768883266367899999999987 Q Ver_Hs_NP_0572 224 VVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQK 303 (523) Q Consensus 224 ~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~Hr 303 (523) .....-.+|+++|.+|+|. +++..+-..-.+.+|=++|+..|.||++...|++-+...|.-. T Consensus 101 -------~~~~~~~~piilvGNK~DL-----------~~~r~V~~~e~~~~a~~~~~~~~E~SAk~~~nV~e~F~~i~r~ 162 (164) T cd04145 101 -------RVKDRDEFPMILVGNKADL-----------EHQRKVSREEGQELARKLKIPYIETSAKDRLNVDKAFHDLVRV 162 (164) T ss_pred -------HHCCCCCCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHH T ss_conf -------5348998479998002580-----------0122059889999999659969999715898878999999997 Q ss_pred H Q ss_conf 6 Q Ver_Hs_NP_0572 304 L 304 (523) Q Consensus 304 L 304 (523) + T Consensus 163 i 163 (164) T cd04145 163 I 163 (164) T ss_pred C T ss_conf 0 No 83 >cd04155 Arl3 Arl3 subfamily. Arl3 (Arf-like 3) is an Arf family protein that differs from most Arf family members in the N-terminal extension. In is inactive, GDP-bound form, the N-terminal extension forms an elongated loop that is hydrophobically anchored into the membrane surface; however, it has been proposed that this region might form a helix in the GTP-bound form. The delta subunit of the rod-specific cyclic GMP phosphodiesterase type 6 (PDEdelta) is an Arl3 effector. Arl3 binds microtubules in a regulated manner to alter specific aspects of cytokinesis via interactions with retinitis pigmentosa 2 (RP2). It has been proposed that RP2 functions in concert with Arl3 to link the cell membrane and the cytoskeleton in photoreceptors as part of the cell signaling or vesicular transport machinery. In mice, the absence of Arl3 is associated with abnormal epithelial cell proliferation and cyst formation. Probab=98.33 E-value=1.5e-06 Score=61.44 Aligned_columns=156 Identities=19% Q ss_pred EEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 58897369976789999974201468886521456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 69 NVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 69 nILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) .|+++|..++|||||+.++..-+-..-.--.++.+-.+...+ .++.+|-+.|...+..+.+.-..-. -.||+ T Consensus 16 kiliiG~~~~GKTsll~~l~~~~~~~~~pT~g~~~~~i~~~~----~~l~~wD~~G~~~~r~~~~~y~~~a----~~iI~ 87 (173) T cd04155 16 RILILGLDNAGKTTILKQLASEDISHITPTQGFNIKTVQSDG----FKLNVWDIGGQRAIRPYWRNYFENT----DCLIY 87 (173) T ss_pred EEEEEEECCCCHHHHHHHHHCCCCCEEEEEEEEEEEEEEECC----EEEEEEECCCHHHHHHHHHHHCCCC----CEEEE T ss_conf 699984089868998888846952214411235889987188----8999986687256799999860667----46899 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |+|-+.+-.+-+....|..+|.+.-.. T Consensus 88 VvD~sd~~~~~~~~~~l~~~L~~~~~~----------------------------------------------------- 114 (173) T cd04155 88 VIDSADKKRLEEAGAELVELLEEEKLA----------------------------------------------------- 114 (173) T ss_pred EEECCCHHHHHHHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 986578445899999999987300338----------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH Q ss_conf 7623005883279985074125555420577478999999999999997187688832663678999999999 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIV 301 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~ 301 (523) ++|++|+++|+|.-..+..+ ++++..=..-..+-.-.++.||++...+++-...+|. T Consensus 115 --------~~PiLi~~NK~Dl~~~~~~~--------ei~~~l~l~~~~~~~~~i~~~SA~tGeGI~e~~~WL~ 171 (173) T cd04155 115 --------GVPVLVFANKQDLATAAPAE--------EIAEALNLHDLRDRTWHIQACSAKTGEGLQEGMNWVC 171 (173) T ss_pred --------CCEEEEEEECCCCCCCCCHH--------HHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHH T ss_conf --------94799997057854368989--------9999975786428946999875235888899999983 No 84 >cd04130 Wrch_1 Wrch-1 subfamily. Wrch-1 (Wnt-1 responsive Cdc42 homolog) is a Rho family GTPase that shares significant sequence and functional similarity with Cdc42. Wrch-1 was first identified in mouse mammary epithelial cells, where its transcription is upregulated in Wnt-1 transformation. Wrch-1 contains N- and C-terminal extensions relative to cdc42, suggesting potential differences in cellular localization and function. The Wrch-1 N-terminal extension contains putative SH3 domain-binding motifs and has been shown to bind the SH3 domain-containing protein Grb2, which increases the level of active Wrch-1 in cells. Unlike Cdc42, which localizes to the cytosol and perinuclear membranes, Wrch-1 localizes extensively with the plasma membrane and endosomes. The membrane association, localization, and biological activity of Wrch-1 indicate an atypical model of regulation distinct from other Rho family GTPases. Most Rho proteins contain a lipid modification site at the C-terminus, Probab=98.32 E-value=1.5e-06 Score=61.36 Aligned_columns=164 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.++..-+-..+-.....-.+...-.-.+..-++.+|=-.|...+..|.+....--+ .+||| T Consensus 3 ivliGd~~VGKTsLi~r~~~~~F~~~~~~T~~~~~~~~i~i~~~~i~l~iwDtaGqe~~~~l~~~~~~~a~----~~ilv 78 (173) T cd04130 3 CVLVGDGAVGKTSLIVSYTTNGYPTEYVPTAFDNFSVVVLVDGKPVRLQLCDTAGQDEFDKLRPLCYPDTD----VFLLC 78 (173) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHCCCCC----EEEEE T ss_conf 89980798438999888761852765331145543477756886799998408987125678786447977----48999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|.+.+-++-.--++|+.-++.+-.. T Consensus 79 ydit~~~Sf~~i~~~w~~~i~~~~~~------------------------------------------------------ 104 (173) T cd04130 79 FSVVNPSSFQNISEKWIPEIRKHNPK------------------------------------------------------ 104 (173) T ss_pred EECCCHHHHHHHHHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 54499768999999889999850899------------------------------------------------------ Q ss_pred CCCCCCCCCCEEEEEECCCH---HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHHHHH Q ss_conf 62300588327998507412---55554205774789999999999999971876888-32663678999999999 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDA---ISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYKYIV 301 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~---ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiY-TS~ke~knl~LLykYl~ 301 (523) +|+++|.+|+|. ...++|....++.+...-. .+.++=++|+.-+| ||+|...|++-+..-+. T Consensus 105 --------~piilVGnK~DL~~~~~~~~~~~~~~~r~Vs~~e--~~~~a~~~~~~~y~EtSAktg~nV~e~F~~~i 170 (173) T cd04130 105 --------APIILVGTQADLRTDVNVLIQLARYGEKPVSQSR--AKALAEKIGACEYIECSALTQKNLKEVFDTAI 170 (173) T ss_pred --------CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHH--HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH T ss_conf --------6499971774411124566544321477789899--99999971895068876147888789999986 No 85 >cd01888 eIF2_gamma eIF2-gamma (gamma subunit of initiation factor 2). eIF2 is a heterotrimeric translation initiation factor that consists of alpha, beta, and gamma subunits. The GTP-bound gamma subunit also binds initiator methionyl-tRNA and delivers it to the 40S ribosomal subunit. Following hydrolysis of GTP to GDP, eIF2:GDP is released from the ribosome. The gamma subunit has no intrinsic GTPase activity, but is stimulated by the GTPase activating protein (GAP) eIF5, and GDP/GTP exchange is stimulated by the guanine nucleotide exchange factor (GEF) eIF2B. eIF2B is a heteropentamer, and the epsilon chain binds eIF2. Both eIF5 and eIF2B-epsilon are known to bind strongly to eIF2-beta, but have also been shown to bind directly to eIF2-gamma. It is possible that eIF2-beta serves simply as a high-affinity docking site for eIF5 and eIF2B-epsilon, or that eIF2-beta serves a regulatory role. eIF2-gamma is found only in eukaryotes and archaea. It is closely related to SelB, the sel Probab=98.32 E-value=4.9e-07 Score=64.55 Aligned_columns=162 Identities=27% Q ss_pred EEEEEECCCCCHHHHHHHHHH-------------------------CCCCCCCCCCEEEEEECCCHHCCHHHHCC----- Q ss_conf 588973699767899999742-------------------------01468886521456404500004325246----- Q Ver_Hs_NP_0572 69 NVLLLGEDGAGKTSLIRKIQG-------------------------IEEYKKGRGLEYLYLNVHDEDRDDQTRCN----- 118 (523) Q Consensus 69 nILvLG~~~sGKTtLl~~Lq~-------------------------~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~----- 118 (523) ||.++|--++|||||+.+|.+ .....++....|.|..+.+.+.-...|+. T Consensus 2 Ni~iiGHVDhGKSTL~~~Ltg~~~~~~~~e~ergITiklG~a~~~i~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 81 (203) T cd01888 2 NIGTIGHVAHGKSTLVKALSGVWTVRFKEELERNITIKLGYANAKIYKCPNCGCPRPYCYRSKEDSPECECPGCGGETKL 81 (203) T ss_pred EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCHHEECCCCCCCCCCCCCCCCEEE T ss_conf 28999873088789999873323443267876276012002344333101212221000000123310001356641123 Q ss_pred ---EEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH Q ss_conf ---3686586243245556787002666455655401013689-999999999999999732789889999999999999 Q Ver_Hs_NP_0572 119 ---VWILDGDLYHKGLLKFSLDAVSLKDTLVMLVVDMSKPWTA-LDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDF 194 (523) Q Consensus 119 ---vWiLdg~~~~~~LLK~aLt~~si~~TLVvIvlDmS~PWt~-m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~ 194 (523) +-++|-+ +|..++++.++--+..+..++++ |-.+ .+ +.|-++-+.+++ T Consensus 82 ~r~itiiD~P-GH~dfi~nmi~Gas~~D~aiLvV-~a~~--g~~~~QT~eH~~~~~------------------------ 133 (203) T cd01888 82 VRHVSFVDCP-GHEILMATMLSGAAVMDGALLLI-AANE--PCPQPQTSEHLAALE------------------------ 133 (203) T ss_pred EEEEEEEECC-CHHHHHHHHHHHHHHCCEEEEEE-ECCC--CCCCHHHHHHHHHHH------------------------ T ss_conf 4688987657-67899999987541137689998-6698--854046899999999------------------------ Q ss_pred HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC-EEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHH Q ss_conf 985045556666553445676667765344788876230058832-7998507412555542057747899999999999 Q Ver_Hs_NP_0572 195 QEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGADTLTHNLGIP-VLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRK 273 (523) Q Consensus 195 q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLgeg~Lt~NLGiP-ivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~ 273 (523) .||++ ++||++|.|... -+|..|.++-|..+|+- T Consensus 134 ----------------------------------------~~gi~~iiv~iNK~Dl~~-----~~~~~~~~~~i~~~l~~ 168 (203) T cd01888 134 ----------------------------------------IMGLKHIIIVQNKIDLVK-----EEQALENYEQIKKFVKG 168 (203) T ss_pred ----------------------------------------HHCCCCEEEEEECCCCCC-----HHHHHHHHHHHHHHHCC T ss_conf ----------------------------------------718994389985378998-----65799999999997321 Q ss_pred HHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 9997187688832663678999999999876 Q Ver_Hs_NP_0572 274 FCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 274 icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) +++. .+-.|..|.+...|++.|...|..++ T Consensus 169 ~~~~-~~~iipiSA~~G~nId~Lle~i~~~i 198 (203) T cd01888 169 TIAE-NAPIIPISAQLKYNIDVLLEYIVKKI 198 (203) T ss_pred CCCC-CEEEEECCCCCCCCHHHHHHHHHHCC T ss_conf 4688-71388622555789889999987217 No 86 >cd04153 Arl5_Arl8 Arl5/Arl8 subfamily. Arl5 (Arf-like 5) and Arl8, like Arl4 and Arl7, are localized to the nucleus and nucleolus. Arl5 is developmentally regulated during embryogenesis in mice. Human Arl5 interacts with the heterochromatin protein 1-alpha (HP1alpha), a nonhistone chromosomal protein that is associated with heterochromatin and telomeres, and prevents telomere fusion. Arl5 may also play a role in embryonic nuclear dynamics and/or signaling cascades. Arl8 was identified from a fetal cartilage cDNA library. It is found in brain, heart, lung, cartilage, and kidney. No function has been assigned for Arl8 to date. Probab=98.31 E-value=3.4e-06 Score=59.04 Aligned_columns=173 Identities=17% Q ss_pred HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCC Q ss_conf 99999988641445425787658897369976789999974201468886521456404500004325246368658624 Q Ver_Hs_NP_0572 48 LWSCILSEVSTRSRSKLPAGKNVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLY 127 (523) Q Consensus 48 lWssiL~~v~t~~~~klp~~KnILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~ 127 (523) |.+++++..-.++. -.|+++|..++|||||+.++..-+-..-.--+++.+-.+.-.. .++.+|-+.|... T Consensus 2 ~~~~~~~~~f~~k~------~kililG~~~sGKTtil~~~~~~~~~~~~pTvg~~~~~i~~~~----~~~~iwD~~Gqe~ 71 (174) T cd04153 2 LFSSLWSLFFPRKE------YKVIIVGLDNAGKTTILYQFLLGEVVHTSPTIGSNVEEIVYKN----IRFLMWDIGGQES 71 (174) T ss_pred HHHHHHHHHCCCCE------EEEEEEEECCCCHHHHHHHHHCCCCCCEECCCCCEEEEEEECC----EEEEEEECCCCCC T ss_conf 04565775148870------6899985089868998888753860320021000588987285----8999987688623 Q ss_pred CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC Q ss_conf 32455567870026664556554010136899999999999999997327898899999999999999850455566665 Q Ver_Hs_NP_0572 128 HKGLLKFSLDAVSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPAS 207 (523) Q Consensus 128 ~~~LLK~aLt~~si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s 207 (523) +.++-+.-..--. .||+|+|.+.+-.+-+..+.|..+|.+.-.+ T Consensus 72 ~r~~w~~y~~~~~----~iI~VvD~sd~~~~~~~~~~l~~~l~~~~~~-------------------------------- 115 (174) T cd04153 72 LRSSWNTYYTNTD----AVILVIDSTDRERLPLTKEELYKMLAHEDLR-------------------------------- 115 (174) T ss_pred CCHHHHHHCCCCC----EEEEEEECCCCCCHHHHHHHHHHHHCCCCCC-------------------------------- T ss_conf 4046675405888----7999996688200788999999985252427-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECC Q ss_conf 53445676667765344788876230058832799850741255554205774789999999999999971876888326 Q Ver_Hs_NP_0572 208 PQRRNTASQEDKDDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSV 287 (523) Q Consensus 208 ~~~~~~~~~~~~d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ 287 (523) .+|++|+++|.|. .-.-..-++++..=...+-++.-.++.||+ T Consensus 116 -----------------------------~~piLIlaNK~Dl--------~~~~~~~ei~~~l~l~~~~~~~~~i~~~SA 158 (174) T cd04153 116 -----------------------------KAVLLVLANKQDL--------KGAMTPAEISESLGLTSIRDHTWHIQGCCA 158 (174) T ss_pred -----------------------------CCEEEEEEECCCC--------CCCCCHHHHHHHHHHHHHHCCCEEEEEEEC T ss_conf -----------------------------9789999606688--------767898999989756766149758998750 Q ss_pred CCHHHHHHHHHHHHHH Q ss_conf 6367899999999987 Q Ver_Hs_NP_0572 288 KENKNIDLVYKYIVQK 303 (523) Q Consensus 288 ke~knl~LLykYl~Hr 303 (523) +...+++-...+|..| T Consensus 159 ~tg~Gi~e~~~WL~~k 174 (174) T cd04153 159 LTGEGLPEGLDWIASR 174 (174) T ss_pred CCCCCHHHHHHHHHCC T ss_conf 2588889999986259 No 87 >cd01883 EF1_alpha Eukaryotic elongation factor 1 (EF1) alpha subfamily. EF1 is responsible for the GTP-dependent binding of aminoacyl-tRNAs to the ribosomes. EF1 is composed of four subunits: the alpha chain which binds GTP and aminoacyl-tRNAs, the gamma chain that probably plays a role in anchoring the complex to other cellular components and the beta and delta (or beta') chains. This subfamily is the alpha subunit, and represents the counterpart of bacterial EF-Tu for the archaea (aEF1-alpha) and eukaryotes (eEF1-alpha). eEF1-alpha interacts with the actin of the eukaryotic cytoskeleton and may thereby play a role in cellular transformation and apoptosis. EF-Tu can have no such role in bacteria. In humans, the isoform eEF1A2 is overexpressed in 2/3 of breast cancers and has been identified as a putative oncogene. This subfamily also includes Hbs1, a G protein known to be important for efficient growth and protein synthesis under conditions of limiting translation initiation in Probab=98.30 E-value=5.7e-07 Score=64.13 Aligned_columns=140 Identities=26% Q ss_pred EEEEEECCCCCHHHHHHHH----------------HHCCCCCCCCCCEEEE-EECCCHHCC------------HHHHCCE Q ss_conf 5889736997678999997----------------4201468886521456-404500004------------3252463 Q Ver_Hs_NP_0572 69 NVLLLGEDGAGKTSLIRKI----------------QGIEEYKKGRGLEYLY-LNVHDEDRD------------DQTRCNV 119 (523) Q Consensus 69 nILvLG~~~sGKTtLl~~L----------------q~~e~~kKg~gLeY~Y-l~V~DeDrd------------d~ar~~v 119 (523) ||+++|--++|||||+.+| .+.+...++ ...|+| +|-.++.|+ ....-.+ T Consensus 1 Ni~iiGHVD~GKSTL~g~LL~~~g~v~~~~~~~~~~~s~~~g~~-s~~~a~~~D~~~~ErerGiTi~~~~~~fet~~~~~ 79 (219) T cd01883 1 NLVVIGHVDAGKSTTTGHLLYLLGGVDKRTIEKYEKEAKEMGKG-SFKYAWVLDTLKEERERGVTIDVGLAKFETEKYRF 79 (219) T ss_pred CEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC-CCHHHEECCCCHHHHHCCCEEEEEEEEEEECCCEE T ss_conf 96899723888688999999984886788999999988760775-20000000366126656960888899997089389 Q ss_pred EEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH Q ss_conf 68658624324555678700266645565540101368----99999999999999997327898899999999999999 Q Ver_Hs_NP_0572 120 WILDGDLYHKGLLKFSLDAVSLKDTLVMLVVDMSKPWT----ALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQ 195 (523) Q Consensus 120 WiLdg~~~~~~LLK~aLt~~si~~TLVvIvlDmS~PWt----~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q 195 (523) -++|-+ +|..+++..+.--+..+..|+++---.--|. .+.|-++-+.+++ T Consensus 80 ~iiD~P-GH~dfi~nmi~Gas~aD~AiLVVdA~~g~fE~~~~~~~QTreH~~l~~------------------------- 133 (219) T cd01883 80 TILDAP-GHRDFVPNMITGASQADVAVLVVDARKGEFEAGFEKGGQTREHALLAR------------------------- 133 (219) T ss_pred EEEECC-CHHHHHHHHHHHHHHCCEEEEEEECCCCCHHCCCCCCCHHHHHHHHHH------------------------- T ss_conf 997083-178899999999875166899987688820003455721799999999------------------------- Q ss_pred HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC-EEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHH Q ss_conf 85045556666553445676667765344788876230058832-79985074125555420577478999999999999 Q Ver_Hs_NP_0572 196 EYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGADTLTHNLGIP-VLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKF 274 (523) Q Consensus 196 ~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLgeg~Lt~NLGiP-ivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~i 274 (523) -||++ |+|+++|-|.++ .+|+++.|+.|.+.++.| T Consensus 134 ---------------------------------------~lGv~~iIVavNKmD~v~-----~~~~~~rf~~I~~~~~~~ 169 (219) T cd01883 134 ---------------------------------------TLGVKQLIVAVNKMDDVT-----VNWSEERYDEIKKELSPF 169 (219) T ss_pred ---------------------------------------HCCCCEEEEEEECCCCCC-----CCCCHHHHHHHHHHHHHH T ss_conf ---------------------------------------808981899984246899-----850278999999999999 Q ss_pred HHHHC Q ss_conf 99718 Q Ver_Hs_NP_0572 275 CLRYG 279 (523) Q Consensus 275 cL~YG 279 (523) +.+.| T Consensus 170 l~~~g 174 (219) T cd01883 170 LKKVG 174 (219) T ss_pred HHHHC T ss_conf 99838 No 88 >cd04157 Arl6 Arl6 subfamily. Arl6 (Arf-like 6) forms a subfamily of the Arf family of small GTPases. Arl6 expression is limited to the brain and kidney in adult mice, but it is expressed in the neural plate and somites during embryogenesis, suggesting a possible role for Arl6 in early development. Arl6 is also believed to have a role in cilia or flagella function. Several proteins have been identified that bind Arl6, including Arl6 interacting protein (Arl6ip), and SEC61beta, a subunit of the heterotrimeric conducting channel SEC61p. Based on Arl6 binding to these effectors, Arl6 is also proposed to play a role in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. At least three specific homozygous Arl6 mutations in humans have been found to cause Bardet-Biedl syndrome, a disorder characterized by obesity, retinopathy, polydactyly, renal and cardiac malformations, learning disabilities, and hypogenitalism. Older literature suggests that A Probab=98.29 E-value=3.3e-06 Score=59.18 Aligned_columns=156 Identities=18% Q ss_pred EEEEEECCCCCHHHHHHHHHH----CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHH Q ss_conf 588973699767899999742----0146888652145640450000432524636865862432455567870026664 Q Ver_Hs_NP_0572 69 NVLLLGEDGAGKTSLIRKIQG----IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDT 144 (523) Q Consensus 69 nILvLG~~~sGKTtLl~~Lq~----~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~T 144 (523) |||++|..++||||||.+|.. .+.....-|..+..+...+ ..+++|-+.|...+.+|.+.-..--. T Consensus 1 ~ivilGl~~aGKTtil~~l~~~~~~~~~~~pTig~~~~~~~~~~------~~~~iwD~~G~~~~r~l~~~y~~~a~---- 70 (162) T cd04157 1 NILVVGLDNSGKTTIINQLKPENAQSQIIVPTVGFNVESFEKGN------LSFTAFDMSGQGKYRGLWEHYYKNIQ---- 70 (162) T ss_pred CEEEEEECCCCHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEECC------EEEEEEEECCCCCHHHHHHHHCCCCC---- T ss_conf 97889508986888887661577301147655520268886086------89999870687201467787515655---- Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 55655401013689999999999999999732789889999999999999985045556666553445676667765344 Q Ver_Hs_NP_0572 145 LVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVV 224 (523) Q Consensus 145 LVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~ 224 (523) .+|+|+|.+.+ .=++..++|+.-+.+|- .+. T Consensus 71 ~iI~VvDssd~-~~~~~~~~~l~~ll~~~-~~~----------------------------------------------- 101 (162) T cd04157 71 GIIFVIDSSDR-LRLVVVKDELELLLNHP-DIK----------------------------------------------- 101 (162) T ss_pred EEEEEEECCCH-HHHHHHHHHHHHHHCCC-CCC----------------------------------------------- T ss_conf 89999856884-46899999999985032-326----------------------------------------------- Q ss_pred CCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH Q ss_conf 78887623005883279985074125555420577478999999999999997187688832663678999999999 Q Ver_Hs_NP_0572 225 VPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIV 301 (523) Q Consensus 225 lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~ 301 (523) |-.+|++|++.|.|. .-.-..-+++...=...+-...-.++-||++...+++-...+|. T Consensus 102 ----------~~~~PiLI~~NK~Dl--------~~~~~~~ei~~~l~l~~~~~~~~~i~~~SA~tG~Gi~e~~~WL~ 160 (162) T cd04157 102 ----------HRRVPILFFANKMDL--------PDALTAVKITQLLGLENIKDKPWHIFASNALTGEGLDEGVQWLQ 160 (162) T ss_pred ----------CCCCEEEEEECCCCC--------CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHH T ss_conf ----------898269999726798--------54689899998874676426836999874345888799999985 No 89 >cd01898 Obg Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain. Probab=98.28 E-value=8.7e-06 Score=56.41 Aligned_columns=158 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHHHC-----CCCCCCCCCEEEEEECCCHHCCHHHHCCEEEEC-CCCCCCCCCCCCCCCCHHHH Q ss_conf 889736997678999997420-----146888652145640450000432524636865-86243245556787002666 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGI-----EEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILD-GDLYHKGLLKFSLDAVSLKD 143 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~-----e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLd-g~~~~~~LLK~aLt~~si~~ 143 (523) |-+.|..++|||||+.+|.+. +.+.-.+---+.+++..+..+ +-+.| ++..-..-...-+..+-+++ T Consensus 3 ValvG~pNvGKSTL~N~Lt~~~~~V~~~~gtT~~~~~g~~~~~~~~~-------i~~vDTpG~~~~~~~~~~l~~~~l~~ 75 (170) T cd01898 3 VGLVGLPNAGKSTLLSAISNAKPKIADYPFTTLVPNLGVVRVDDGRS-------FVVADIPGLIEGASEGKGLGHRFLRH 75 (170) T ss_pred EEEEECCCCCHHHHHHHHHCCCCEEECCCCCCCCEEEEEEEECCCCE-------EEEEECCCCCCCCCCCHHHHHHHHHH T ss_conf 56642799858999989862861121236775110135898659843-------89985252012542213479999998 Q ss_pred H----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC Q ss_conf 4----556554010136899999999999999997327898899999999999999850455566665534456766677 Q Ver_Hs_NP_0572 144 T----LVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDK 219 (523) Q Consensus 144 T----LVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~ 219 (523) . +|++++|.+.+|..+++++.-...|..+-.++. T Consensus 76 i~~ad~ii~vvD~~~~~~~~~~~~~i~~~l~~~~~~l~------------------------------------------ 113 (170) T cd01898 76 IERTRLLLHVIDLSGDDDPVEDYKTIRNELELYNPELL------------------------------------------ 113 (170) T ss_pred HHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCHHHH------------------------------------------ T ss_conf 85088789997458866868899999999986121221------------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHH Q ss_conf 65344788876230058832799850741255554205774789999999999999971876888326636789999999 Q Ver_Hs_NP_0572 220 DDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKY 299 (523) Q Consensus 220 d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykY 299 (523) +-|+++|.+|+|.+ -.++.+..+..+++.+ ++...|++|++...+++-|..+ T Consensus 114 -----------------~kp~iiv~NK~Dl~--------~~~~~~~~~~~~~~~~---~~~~ii~iSA~~g~gi~~L~~~ 165 (170) T cd01898 114 -----------------EKPRIVVLNKIDLL--------DEEELFELLKELLKEL---WGKPVFPISALTGEGLDELLRK 165 (170) T ss_pred -----------------CCCEEEEEECCCCC--------CHHHHHHHHHHHHHHC---CCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------48689998165610--------2440048999999844---8997899834678887899999 Q ss_pred HHHHH Q ss_conf 99876 Q Ver_Hs_NP_0572 300 IVQKL 304 (523) Q Consensus 300 l~HrL 304 (523) |...| T Consensus 166 i~elL 170 (170) T cd01898 166 LAELL 170 (170) T ss_pred HHHHC T ss_conf 99839 No 90 >cd04173 Rnd2_Rho7 Rnd2/Rho7 subfamily. Rnd2/Rho7 is a member of the novel Rho subfamily Rnd, together with Rnd1/Rho6 and Rnd3/RhoE/Rho8. Rnd2/Rho7 is transiently expressed in radially migrating cells in the brain while they are within the subventricular zone of the hippocampus and cerebral cortex. These migrating cells typically develop into pyramidal neurons. Cells that exogenously expressed Rnd2/Rho7 failed to migrate to upper layers of the brain, suggesting that Rnd2/Rho7 plays a role in the radial migration and morphological changes of developing pyramidal neurons, and that Rnd2/Rho7 degradation is necessary for proper cellular migration. The Rnd2/Rho7 GEF Rapostlin is found primarily in the brain and together with Rnd2/Rho7 induces dendrite branching. Unlike Rnd1/Rho6 and Rnd3/RhoE/Rho8, which are RhoA antagonists, Rnd2/Rho7 binds the GEF Pragmin and significantly stimulates RhoA activity and Rho-A mediated cell contraction. Rnd2/Rho7 is also found to be expressed in sperma Probab=98.28 E-value=2.7e-06 Score=59.75 Aligned_columns=152 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+||.++..-.=..+-...-+-.+.+.=+-.+..-.+++|=-.|...+..|.+....--+ .++|| T Consensus 4 iVvvGD~~VGKTsLl~~f~~~~F~~~y~PTV~~~~~~~i~vd~~~V~L~lWDTAGQE~y~~lr~~yYr~ad----~~llv 79 (222) T cd04173 4 IVVVGDAECGKTALLQVFAKDAYPGSYVPTVFENYTASFEIDKRRIELNMWDTSGSSYYDNVRPLAYPDSD----AVLIC 79 (222) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHCCCC----EEEEE T ss_conf 99971698337888887643710675244157657999999886999998734887012344477633898----79999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|++.|-+|-.=..+|+..++++-. T Consensus 80 FdIt~~~SF~nv~~kW~~ei~~~~p------------------------------------------------------- 104 (222) T cd04173 80 FDISRPETLDSVLKKWQGETQEFCP------------------------------------------------------- 104 (222) T ss_pred EECCCHHHHHHHHHHHHHHHHHHCC------------------------------------------------------- T ss_conf 8658854789999988899997079------------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHH--------HHHHHHHHHHHHHCC-EEEEECCCCHHH-HH Q ss_conf 623005883279985074125555420577478999--------999999999997187-688832663678-99 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFD--------FFQSHIRKFCLRYGA-ALIYTSVKENKN-ID 294 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fD--------fIqq~LR~icL~YGA-aLiYTS~ke~kn-l~ 294 (523) .+||++|.||+|. ++=.+...+ +=..-=..++-+.|| ..+=||+|.+.| ++ T Consensus 105 -------~~pIILVGnK~DL-------R~D~~~~~~l~~~~~~pVs~eeg~~lA~~igA~~y~EcSAk~~~n~V~ 165 (222) T cd04173 105 -------NAKVVLVGCKLDM-------RTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVECSSRSSERSVR 165 (222) T ss_pred -------CCCEEEECCCCCC-------CCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHH T ss_conf -------9848998036676-------589889999985689988989999999973982136530457996678 No 91 >cd04158 ARD1 ARD1 subfamily. ARD1 (ADP-ribosylation factor domain protein 1) is an unusual member of the Arf family. In addition to the C-terminal Arf domain, ARD1 has an additional 46-kDa N-terminal domain that contains a RING finger domain, two predicted B-Boxes, and a coiled-coil protein interaction motif. This domain belongs to the TRIM (tripartite motif) or RBCC (RING, B-Box, coiled-coil) family. Like most Arfs, the ARD1 Arf domain lacks detectable GTPase activity. However, unlike most Arfs, the full-length ARD1 protein has significant GTPase activity due to the GAP (GTPase-activating protein) activity exhibited by the 46-kDa N-terminal domain. The GAP domain of ARD1 is specific for its own Arf domain and does not bind other Arfs. The rate of GDP dissociation from the ARD1 Arf domain is slowed by the adjacent 15 amino acids, which act as a GDI (GDP-dissociation inhibitor) domain. ARD1 is ubiquitously expressed in cells and localizes to the Golgi and to the lysosomal membra Probab=98.25 E-value=4.5e-06 Score=58.26 Aligned_columns=159 Identities=25% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) ||++|..++||||++.+|...+-...---.+|..-.+...+ .++.+|-+.|...+.++-+.-..--. .||+| T Consensus 2 IliiGl~~aGKTtil~~l~~~~~~~~~pTvG~~~~~i~~~~----~~l~iwD~gG~~~~r~~w~~Yy~~~~----giIfV 73 (169) T cd04158 2 VVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNVETVEYKN----LKFTIWDVGGKHKLRPLWKHYYLNTQ----AVVFV 73 (169) T ss_pred EEEEEECCCCHHHHHHHHHCCCCCCEEEEECEEEEEEEECC----EEEEEEECCCCCHHHHHHHHHHCCCC----EEEEE T ss_conf 88996279868998888855831431210120688887457----49999873887402577887504766----89999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) +|.+..-.+-+....|.++|.+ T Consensus 74 vDssd~~~~~e~~~~l~~ll~~---------------------------------------------------------- 95 (169) T cd04158 74 VDSSHRDRVSEAHSELAKLLTE---------------------------------------------------------- 95 (169) T ss_pred EECCCHHHHHHHHHHHHHHHCC---------------------------------------------------------- T ss_conf 9655633589999999998445---------------------------------------------------------- Q ss_pred CCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHH Q ss_conf 623005883279985074125555420577478999999999999997187688832663678999999999876 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKL 304 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrL 304 (523) ...-++|++|++.|.|.-..+..+ |-.++++ |+++|-..--.++.||++...+++=....|..+| T Consensus 96 ---~~~~~~piLi~aNK~Dl~~~~~~~-----ei~~~l~--l~~~~~~r~~~i~~~SA~tG~Gi~E~f~WL~~~l 160 (169) T cd04158 96 ---KELRDALLLIFANKQDVAGALSVE-----EMTELLS--LHKLCCGRSWYIQGCDARSGMGLYEGLDWLSRQL 160 (169) T ss_pred ---CCCCCCEEEEEECCCCCCCCCCHH-----HHHHHHH--HHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHH T ss_conf ---101695699985155887688989-----9998963--6877338956999752346888789999999998 No 92 >cd01892 Miro2 Miro2 subfamily. Miro (mitochondrial Rho) proteins have tandem GTP-binding domains separated by a linker region containing putative calcium-binding EF hand motifs. Genes encoding Miro-like proteins were found in several eukaryotic organisms. This CD represents the putative GTPase domain in the C terminus of Miro proteins. These atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. Most Rho proteins contain a lipid modification site at the C-terminus; however, Miro is one of few Rho subfamilies that lack this feature. Probab=98.23 E-value=2.2e-06 Score=60.32 Aligned_columns=152 Identities=27% Q ss_pred EEEEECCCCCHHHHHHHHHH----CCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHH Q ss_conf 88973699767899999742----01468886521456404500004325246368658624324555678700266645 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQG----IEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTL 145 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~----~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TL 145 (523) |+|||+.++|||+|+.++.. .+.+...-|.+|.--.|.=.+++ -.+..|-..|.-.+..|.+.-.-.-.. T Consensus 7 ~~vlGd~gVGKTsll~rfv~~~F~~~~y~~Tig~~f~~k~v~v~g~~--~~l~l~Dtagqe~~~~l~~~~~~~a~~---- 80 (169) T cd01892 7 CFVLGAKGSGKSALLRAFLGRSFSLNAYSPTIKPRYAVNTVEVYGQE--KYLILREVGEDEVAILLNDAELAACDV---- 80 (169) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCEE--EEEEEECCCCHHHHHHHHHHHCCCCCE---- T ss_conf 99980899648999999856874666211520231679888876747--899851157303454431322058878---- Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 56554010136899999999999999997327898899999999999999850455566665534456766677653447 Q Ver_Hs_NP_0572 146 VMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVV 225 (523) Q Consensus 146 VvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~l 225 (523) ++||-|.+.|-+| +.+.+| ++.+...+. T Consensus 81 ~ilVYDit~~~SF-~~i~~~----------------------------~~~~~~~~~----------------------- 108 (169) T cd01892 81 ACLVYDSSDPKSF-SYCAEV----------------------------YKKYFMLGE----------------------- 108 (169) T ss_pred EEEEEECCCHHHH-HHHHHH----------------------------HHHCCCCCC----------------------- T ss_conf 9999867997899-999999----------------------------986048999----------------------- Q ss_pred CCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEE-EEECCCCHHHHHHHHHHHHH Q ss_conf 888762300588327998507412555542057747899999999999999718768-88326636789999999998 Q Ver_Hs_NP_0572 226 PLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAAL-IYTSVKENKNIDLVYKYIVQ 302 (523) Q Consensus 226 PLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaL-iYTS~ke~knl~LLykYl~H 302 (523) +|+++|.+|+|. +|+..+=.+--+.||-++|... +.||+|...|++=+..-|.+ T Consensus 109 ------------ipiilVGNK~DL-----------~~~RqVs~~e~~~~a~~~g~~~~~e~SAKtg~nV~e~F~~la~ 163 (169) T cd01892 109 ------------IPCLFVAAKADL-----------DEQQQRYEVQPDEFCRKLGLPPPLHFSSKLGDSSNELFTKLAT 163 (169) T ss_pred ------------CEEEEEECCCCC-----------CCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH T ss_conf ------------559998303677-----------5556336337689999629996368870179998999999999 No 93 >cd00882 Ras_like_GTPase Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulate initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Memb Probab=98.23 E-value=2.5e-06 Score=59.92 Aligned_columns=156 Identities=23% Q ss_pred EEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH Q ss_conf 973699767899999742014688865-2145640450000432524636865862432455567870026664556554 Q Ver_Hs_NP_0572 72 LLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLVV 150 (523) Q Consensus 72 vLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIvl 150 (523) |+|+.++|||||+.++.+..-...... ....+....-......-++.+|-+.|........+.....-. .+++|. T Consensus 1 ivG~~~~GKtsli~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~i~D~~G~~~~~~~~~~~~~~~~----~~i~v~ 76 (157) T cd00882 1 VVGDSGVGKTSLLNRLLGGEFVPEEYETTIIDFYSKTIEVDGKKVKLQIWDTAGQERFRSLRRLYYRGAD----GIILVY 76 (157) T ss_pred CCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCC----EEEEEE T ss_conf 9048888889999998648105674563057888874244111468986157873446677788614898----899997 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 01013689999999999999999732789889999999999999985045556666553445676667765344788876 Q Ver_Hs_NP_0572 151 DMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGAD 230 (523) Q Consensus 151 DmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLgeg 230 (523) |.+.+..+....+.|...+...... T Consensus 77 d~~~~~s~~~~~~~~~~~~~~~~~~------------------------------------------------------- 101 (157) T cd00882 77 DVTDRESFENVKEWLLLILINKEGE------------------------------------------------------- 101 (157) T ss_pred ECCCCCCHHHHHHHHHHHHHHHCCC------------------------------------------------------- T ss_conf 2786000677899999999851589------------------------------------------------------- Q ss_pred CCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHH Q ss_conf 230058832799850741255554205774789999999999999971876888326636789999999998 Q Ver_Hs_NP_0572 231 TLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQ 302 (523) Q Consensus 231 ~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~H 302 (523) ++|++||++|+|..+ .+....++ ..+.++..++...+.+|.+...+++.+.+.|.. T Consensus 102 ------~~piiiv~nK~Dl~~---~~~~~~~~-------~~~~~~~~~~~~~~~~Sa~~~~~i~~~~~~i~~ 157 (157) T cd00882 102 ------NIPIILVGNKIDLPE---ERVVSEEE-------LAEQLAKELGVPYFETSAKTGENVEELFEELAE 157 (157) T ss_pred ------CCEEEEEECCCCHHH---HHHHHHHH-------HHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCC T ss_conf ------978999812558024---44323378-------999999845981899861589787899999709 No 94 >smart00177 ARF ARF-like small GTPases; ARF, ADP-ribosylation factor; Ras homologues involved in vesicular transport. Activator of phospholipase D isoforms. Unlike Ras proteins they lack cysteine residues at their C-termini and therefore are unlikely to be prenylated. ARFs are N-terminally myristoylated. Contains ATP/GTP-binding motif (P-loop). Probab=98.21 E-value=4.2e-06 Score=58.48 Aligned_columns=177 Identities=18% Q ss_pred HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCC Q ss_conf 79999998864144542578765889736997678999997420146888652145640450000432524636865862 Q Ver_Hs_NP_0572 47 NLWSCILSEVSTRSRSKLPAGKNVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDL 126 (523) Q Consensus 47 nlWssiL~~v~t~~~~klp~~KnILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~ 126 (523) +|-+++-+..-.++. -.|+++|..++|||||+.+|..-+....---.++.+-.+.- ...++.+|-+.|.. T Consensus 3 ~~~~~~~~~~f~kk~------~kiviiG~~~~GKTtil~~l~~~~~~~~~pTvg~~~~~i~~----~~~~l~iwD~~Gqe 72 (181) T smart00177 3 LYAGKLFSKLFGNKE------MRILMVGLDAAGKTTILYKLKLGESVTTIPTIGFNVETVTY----KNISFTVWDVGGQD 72 (181) T ss_pred CHHHHHHHHHHCCCC------EEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCEEEEEE----CCEEEEEEECCCCH T ss_conf 026777777516770------68999851898789999987528733022000010356641----43599998748734 Q ss_pred CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC Q ss_conf 43245556787002666455655401013689999999999999999732789889999999999999985045556666 Q Ver_Hs_NP_0572 127 YHKGLLKFSLDAVSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPA 206 (523) Q Consensus 127 ~~~~LLK~aLt~~si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~ 206 (523) .+.++-+.-..--. .||+|+|.+..-.+-+....|..++.+. T Consensus 73 ~~r~lw~~Yy~~a~----~iI~VvD~sd~~~~~~~~~~l~~~l~~~---------------------------------- 114 (181) T smart00177 73 KIRPLWRHYYTNTQ----GLIFVVDSNDRDRIDEAREELHRMLNED---------------------------------- 114 (181) T ss_pred HHHHHHHHHCCCCC----EEEEEEECCCHHHHHHHHHHHHHHHCCC---------------------------------- T ss_conf 57888887606896----8999986588334899999999985020---------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEC Q ss_conf 55344567666776534478887623005883279985074125555420577478999999999999997187688832 Q Ver_Hs_NP_0572 207 SPQRRNTASQEDKDDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTS 286 (523) Q Consensus 207 s~~~~~~~~~~~~d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS 286 (523) ..-++|++|++.|.|.-+.+..++--.+...+.++. ..-.++.|| T Consensus 115 ---------------------------~~~~~pilIl~NK~Dl~~~~~~~ei~~~l~l~~~~~--------~~~~i~~~S 159 (181) T smart00177 115 ---------------------------ELRDAVILVFANKQDLPDAMKAAEITEKLGLHSIRD--------RNWYIQPTC 159 (181) T ss_pred ---------------------------CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCC--------CCEEEEEEE T ss_conf ---------------------------227978999950558302179999998863676426--------975899862 Q ss_pred CCCHHHHHHHHHHHHHHHCC Q ss_conf 66367899999999987606 Q Ver_Hs_NP_0572 287 VKENKNIDLVYKYIVQKLYG 306 (523) Q Consensus 287 ~ke~knl~LLykYl~HrLyg 306 (523) ++...+++-....|...+.+ T Consensus 160 A~tG~GI~e~f~WL~~~ik~ 179 (181) T smart00177 160 ATSGDGLYEGLTWLSNNLKN 179 (181) T ss_pred CCCCCCHHHHHHHHHHHHHH T ss_conf 45688889999999999641 No 95 >cd04174 Rnd1_Rho6 Rnd1/Rho6 subfamily. Rnd1/Rho6 is a member of the novel Rho subfamily Rnd, together with Rnd2/Rho7 and Rnd3/RhoE/Rho8. Rnd1/Rho6 binds GTP but does not hydrolyze it to GDP, indicating that it is constitutively active. In rat, Rnd1/Rho6 is highly expressed in the cerebral cortex and hippocampus during synapse formation, and plays a role in spine formation. Rnd1/Rho6 is also expressed in the liver and in endothelial cells, and is upregulated in uterine myometrial cells during pregnancy. Like Rnd3/RhoE/Rho8, Rnd1/Rho6 is believed to function as an antagonist to RhoA. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. Probab=98.17 E-value=6.7e-06 Score=57.15 Aligned_columns=185 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH Q ss_conf 88973699767899999742014688865214564045000043252463686586243245556787002666455655 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLV 149 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvIv 149 (523) |+++|+.++|||+|+.++..-.-..+-.+--+..+...=+-.+..-.+++|=-.|...+..|.+....--+ .++|| T Consensus 16 iVlVGD~~VGKTsLl~~~~~~~F~~~y~pTv~~~y~~~i~v~~~~v~L~lWDTAGQE~y~~lrplyYr~ad----~~llv 91 (232) T cd04174 16 LVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTAGLETEEQRVELSLWDTSGSPYYDNVRPLCYSDSD----AVLLC 91 (232) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHCCCCC----EEEEE T ss_conf 99983597138899988743722765144277657999988795899988526898035678785235646----79999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 40101368999999999999999973278988999999999999998504555666655344567666776534478887 Q Ver_Hs_NP_0572 150 VDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLGA 229 (523) Q Consensus 150 lDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLge 229 (523) -|++.|-+|-.-+++|+.-++++-.. T Consensus 92 Fdit~~~Sfenv~~kW~~Ei~~~~p~------------------------------------------------------ 117 (232) T cd04174 92 FDISRPETVDSALKKWKAEIMDYCPS------------------------------------------------------ 117 (232) T ss_pred EECCCHHHHHHHHHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 75487457888898306889872789------------------------------------------------------ Q ss_pred CCCCCCCCCCEEEEEECCC------HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCHH-HH----HHHH Q ss_conf 6230058832799850741------255554205774789999999999999971876888-3266367-89----9999 Q Ver_Hs_NP_0572 230 DTLTHNLGIPVLVVCTKCD------AISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIY-TSVKENK-NI----DLVY 297 (523) Q Consensus 230 g~Lt~NLGiPivVVctKsD------~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiY-TS~ke~k-nl----~LLy 297 (523) +||++|.||+| .+..|.++ .+.-+--.--..++=++||..++ ||++... |+ +..- T Consensus 118 --------~pIiLVGnK~DLR~d~~~~~~L~~~-----~~~pVt~eeG~~~Ak~iga~~Y~EcSA~tge~~V~~vF~~a~ 184 (232) T cd04174 118 --------TRILLIGCKTDLRTDLSTLMELSNQ-----KQAPISYEQGCALAKQLGAEVYLECSAFTSEKSIHSIFRSAS 184 (232) T ss_pred --------CEEEEEECCCCCCCCHHHHHHHHHC-----CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHH T ss_conf --------7189984465554798899999856-----898879899999999739817887300102456789999999 Q ss_pred HHHHHHHCCCCCCCCCCCCCCCEEEECC Q ss_conf 9999876065556556411364025268 Q Ver_Hs_NP_0572 298 KYIVQKLYGFPYKIPAVVVEKDAVFIPA 325 (523) Q Consensus 298 kYl~HrLygfpf~~~a~ViDrD~IfIPa 325 (523) .-.+.++-+-.-+.++--+.+..+-+|+ T Consensus 185 ~~~l~~~~~~~~~s~~~~~~~~~~~~p~ 212 (232) T cd04174 185 LLCLNKLSPPIKKSPVRSLSKRLLHLPS 212 (232) T ss_pred HHHHHHCCCCCCCCCHHHCCCCCCCCCC T ss_conf 9998620122343410120443113788 No 96 >cd01889 SelB_euk SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of SelB recognizes this hairpin, while the N-terminal part binds GTP and tRNA in analogy with elongation factor Tu (EF-Tu). It specifically recognizes the selenocysteine charged tRNAsec, which has a UCA anticodon, in an EF-Tu like manner. This allows insertion of selenocysteine at in-frame UGA stop codons. In E. coli SelB binds GTP, selenocysteyl-tRNAsec and a stem-loop structure immediately downstream of the UGA codon (the SECIS sequence). The absence of active SelB prevents the participation of selenocysteyl-tRNAsec in translation. Archaeal and animal mechanisms of selenocysteine incorporation are more complex. Although the SECIS elements have different secondary structures and conserved elements between archaea and euk Probab=98.15 E-value=4.2e-06 Score=58.46 Aligned_columns=163 Identities=23% Q ss_pred EEEEEECCCCCHHHHHHHHHHC----------CCCCCCCC--CEEEEEECCCHH------CCHHHHCCEEEECCCCCCCC Q ss_conf 5889736997678999997420----------14688865--214564045000------04325246368658624324 Q Ver_Hs_NP_0572 69 NVLLLGEDGAGKTSLIRKIQGI----------EEYKKGRG--LEYLYLNVHDED------RDDQTRCNVWILDGDLYHKG 130 (523) Q Consensus 69 nILvLG~~~sGKTtLl~~Lq~~----------e~~kKg~g--LeY~Yl~V~DeD------rdd~ar~~vWiLdg~~~~~~ 130 (523) ||-|+|--++|||||+++|.++ ++...|-- |+|+++.+...+ ..+..+..+=++|-+ +|.. T Consensus 2 Ni~iiGHVDhGKTTL~~~L~~~~~~~~~D~~~~E~eRGITi~lg~~~f~~~~~~~~~~~~~~~~~~~~i~~IDtP-GH~d 80 (192) T cd01889 2 NVGVLGHVDSGKTSLAKALSEIASTAAFDKNPQSQERGITLDLGFSSFYVDKPKHLRELINPGEENLQITLVDCP-GHAS 80 (192) T ss_pred EEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEECCEEEEECCHHHHCCCCCCCCCCEEEEEEECC-CHHH T ss_conf 188998630787799999875432211045346776584024210113411101000012457664279997556-6688 Q ss_pred CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC Q ss_conf 55567870026664556554010136899999999999999997327898899999999999999850455566665534 Q Ver_Hs_NP_0572 131 LLKFSLDAVSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQR 210 (523) Q Consensus 131 LLK~aLt~~si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~ 210 (523) .++..+..-++.+..|+++---.- ++.|-++-+.+++ T Consensus 81 F~~~m~~G~~~~D~aiLvV~a~~G---v~~QT~eh~~~~~---------------------------------------- 117 (192) T cd01889 81 LIRTIIGGAQIIDLMLLVVDATKG---IQTQTAECLVIGE---------------------------------------- 117 (192) T ss_pred HHHHHHHHHHHHCEEEEEEECCCC---CCCCHHHHHHHHH---------------------------------------- T ss_conf 999999998763406888845788---5744689999999---------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCE---EEEECC Q ss_conf 45676667765344788876230058832799850741255554205774789999999999999971876---888326 Q Ver_Hs_NP_0572 211 RNTASQEDKDDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAA---LIYTSV 287 (523) Q Consensus 211 ~~~~~~~~~d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAa---LiYTS~ 287 (523) .+|+|++||++|.|.+. ..|.++.|+.|.+.|..+.-+.+.. +|.+|. T Consensus 118 ------------------------~~~~~~iv~iNKiD~v~-----~~~~~~~~~~ik~~i~~~l~~~~~~~~~iipiSA 168 (192) T cd01889 118 ------------------------ILCKKLIVVLNKIDLIP-----EEERERKIEKMKKKLQKTLEKTRFKNSPIIPVSA 168 (192) T ss_pred ------------------------HCCCCEEEEEEECCCCC-----CCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC T ss_conf ------------------------72897799997327899-----4045789999999999885113788712687037 Q ss_pred CCHHHHHHHHHHHHHHH Q ss_conf 63678999999999876 Q Ver_Hs_NP_0572 288 KENKNIDLVYKYIVQKL 304 (523) Q Consensus 288 ke~knl~LLykYl~HrL 304 (523) +...|++-|.+.|-..+ T Consensus 169 ~tG~gI~eL~~~~~~~~ 185 (192) T cd01889 169 KPGGGEAELGKDLNNLI 185 (192) T ss_pred CCCCCHHHHHHHHHHHC T ss_conf 78998799999887534 No 97 >cd04149 Arf6 Arf6 subfamily. Arf6 (ADP ribosylation factor 6) proteins localize to the plasma membrane, where they perform a wide variety of functions. In its active, GTP-bound form, Arf6 is involved in cell spreading, Rac-induced formation of plasma membrane ruffles, cell migration, wound healing, and Fc-mediated phagocytosis. Arf6 appears to change the actin structure at the plasma membrane by activating Rac, a Rho family protein involved in membrane ruffling. Arf6 is required for and enhances Rac formation of ruffles. Arf6 can regulate dendritic branching in hippocampal neurons, and in yeast it localizes to the growing bud, where it plays a role in polarized growth and bud site selection. In leukocytes, Arf6 is required for chemokine-stimulated migration across endothelial cells. Arf6 also plays a role in down-regulation of beta2-adrenergic receptors and luteinizing hormone receptors by facilitating the release of sequestered arrestin to allow endocytosis. Arf6 is believed t Probab=98.12 E-value=9.7e-06 Score=56.10 Aligned_columns=156 Identities=17% Q ss_pred EEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHH Q ss_conf 58897369976789999974201468886521456404500004325246368658624324555678700266645565 Q Ver_Hs_NP_0572 69 NVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVML 148 (523) Q Consensus 69 nILvLG~~~sGKTtLl~~Lq~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TLVvI 148 (523) .||++|..++|||||+.+|..-+....--..+|.+-.+.-.+ .++++|-+.|...+..+.+.-..--. .||+ T Consensus 11 kililGl~~sGKTtil~~l~~~~~~~~~pTvg~~~~~~~~~~----~~l~iwD~~Gqe~~r~lw~~Yy~~a~----~iif 82 (168) T cd04149 11 RILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKN----VKFNVWDVGGQDKIRPLWRHYYTGTQ----GLIF 82 (168) T ss_pred EEEEEEECCCCHHHHHHHHHCCCCCEEEEEEEEEEEEEEECC----EEEEEEECCCCHHHHHHHHHHCCCCC----EEEE T ss_conf 899985089878898877643861024300124788987447----28999872871356776586506887----7999 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 54010136899999999999999997327898899999999999999850455566665534456766677653447888 Q Ver_Hs_NP_0572 149 VVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVVPLG 228 (523) Q Consensus 149 vlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~lPLg 228 (523) |+|-+..-.+-+....|..+|.+.-.. T Consensus 83 VvD~sd~~~l~~~~~~l~~~l~~~~~~----------------------------------------------------- 109 (168) T cd04149 83 VVDSADRDRIDEARQELHRIINDREMR----------------------------------------------------- 109 (168) T ss_pred EEECCCCCCHHHHHHHHHHHHCCCCCC----------------------------------------------------- T ss_conf 982577322788999999985131327----------------------------------------------------- Q ss_pred CCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH Q ss_conf 7623005883279985074125555420577478999999999999997187688832663678999999999 Q Ver_Hs_NP_0572 229 ADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIV 301 (523) Q Consensus 229 eg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~ 301 (523) ++|++|+++|.|. .-.-..-++.+.+--..+-.+.-.++.||++...+++--..+|. T Consensus 110 --------~~pili~~NK~Dl--------~~~~~~~ei~~~l~l~~~~~~~~~i~~~SA~tG~Gi~e~~~WL~ 166 (168) T cd04149 110 --------DALLLVFANKQDL--------PDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLS 166 (168) T ss_pred --------CCEEEEEEECCCC--------CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHH T ss_conf --------9789999615688--------65779899998864687516965899851456888799999985 No 98 >cd04142 RRP22 RRP22 subfamily. RRP22 (Ras-related protein on chromosome 22) subfamily consists of proteins that inhibit cell growth and promote caspase-independent cell death. Unlike most Ras proteins, RRP22 is down-regulated in many human tumor cells due to promoter methylation. RRP22 localizes to the nucleolus in a GTP-dependent manner, suggesting a novel function in modulating transport of nucleolar components. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Like most Ras family proteins, RRP22 is farnesylated. Probab=98.08 E-value=1.6e-05 Score=54.69 Aligned_columns=157 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHHCCCCCCCCC-CEEEEEECCCHHCCHHHHCCEEE---------ECCCCCCCCCCCCCCCCC Q ss_conf 88973699767899999742014688865-21456404500004325246368---------658624324555678700 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKIQGIEEYKKGRG-LEYLYLNVHDEDRDDQTRCNVWI---------LDGDLYHKGLLKFSLDAV 139 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~Lq~~e~~kKg~g-LeY~Yl~V~DeDrdd~ar~~vWi---------Ldg~~~~~~LLK~aLt~~ 139 (523) |++||+.++|||+|+.++..-+-...-.. .+.-|+...-.-......+++|- ..|..+...--+..-++. T Consensus 3 VvilGd~gVGKTsli~Rf~~~~F~~~y~pTig~~~~~k~i~vdg~~~~L~IwDt~~~~~~~~tagqE~~~~r~r~lr~ad 82 (198) T cd04142 3 VAVLGAPGVGKTAIVRQFLAQEFPEEYIPTEHRRLYRPAVVLSGRVYDLHILDVPNMQRYPGTAGQEWMDPRFRGLRNSR 82 (198) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCC T ss_conf 89981898418999988761743776356421014687898989799999841443111456553011112221012786 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC Q ss_conf 26664556554010136899999999999999997327898899999999999999850455566665534456766677 Q Ver_Hs_NP_0572 140 SLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDK 219 (523) Q Consensus 140 si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~ 219 (523) - +|||-|.+.+-+| +.+..|...+.+.-... T Consensus 83 ~-----~ilVydIt~~~SF-~~v~~~~~~i~~~~~~~------------------------------------------- 113 (198) T cd04142 83 A-----FILVYDICSPDSF-HYVKLLRQQILETRPAG------------------------------------------- 113 (198) T ss_pred E-----EEEEEECCCHHHH-HHHHHHHHHHHHHCCCC------------------------------------------- T ss_conf 7-----9999867996688-99999999999851358------------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCHHHHHHHHH Q ss_conf 65344788876230058832799850741255554205774789999999999999971876888-32663678999999 Q Ver_Hs_NP_0572 220 DDSVVVPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIY-TSVKENKNIDLVYK 298 (523) Q Consensus 220 d~~v~lPLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiY-TS~ke~knl~LLyk 298 (523) +-.+||++|.+|+|. +++.-+-.+-...++-+-++..+| ||+|++.|++-+.+ T Consensus 114 ---------------~~~~pivLVGNK~DL-----------~~~R~v~~e~~~~~a~~~~~~~f~EtSAK~~~NV~elF~ 167 (198) T cd04142 114 ---------------NKEPPIVVVGNKRDQ-----------QRHRFAPRHVLSVLVRKSWKCGYLECSAKYNWHILLLFK 167 (198) T ss_pred ---------------CCCCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf ---------------999679998247652-----------115526789999999982797379986137988889999 Q ss_pred HHH Q ss_conf 999 Q Ver_Hs_NP_0572 299 YIV 301 (523) Q Consensus 299 Yl~ 301 (523) -|+ T Consensus 168 ~lv 170 (198) T cd04142 168 ELL 170 (198) T ss_pred HHH T ss_conf 999 No 99 >cd04166 CysN_ATPS CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which catalyzes ATP hydrolysis, is a member of the ATP pyrophosphatase (ATP PPase) family. CysN hydrolysis of GTP is required for CysD hydrolysis of ATP; however, CysN hydrolysis of GTP is not dependent on CysD hydrolysis of ATP. CysN is an example of lateral gene transfer followed by acquisition of new function. In many organisms, an ATPS exists which is not GTP-dependent and shares no sequence or structural similarity to CysN. Probab=98.06 E-value=9.7e-06 Score=56.09 Aligned_columns=150 Identities=27% Q ss_pred EEEEEECCCCCHHHHH---------------HHHHHCCCCCCCCCCEEEE-EECCCHHCC------------HHHHCCEE Q ss_conf 5889736997678999---------------9974201468886521456-404500004------------32524636 Q Ver_Hs_NP_0572 69 NVLLLGEDGAGKTSLI---------------RKIQGIEEYKKGRGLEYLY-LNVHDEDRD------------DQTRCNVW 120 (523) Q Consensus 69 nILvLG~~~sGKTtLl---------------~~Lq~~e~~kKg~gLeY~Y-l~V~DeDrd------------d~ar~~vW 120 (523) +++++|--++|||||+ .++............+|+| +|..++.|+ ....-.+= T Consensus 1 ~~vv~GHVD~GKSTL~grLL~~~g~v~~~~l~~~~~~~~~~~~~~~~~a~~lD~~~eErerGiTId~~~~~f~~~~~~~~ 80 (208) T cd04166 1 RFLTCGSVDDGKSTLIGRLLYDSKSIFEDQLAALESKSCGTGGEPLDLALLVDGLQAEREQGITIDVAYRYFSTPKRKFI 80 (208) T ss_pred CEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCEEEEEEEEEECCCCEEE T ss_conf 97889613788578999999972886788999999877650343201232307734566569548888899834897899 Q ss_pred EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC Q ss_conf 86586243245556787002666455655401013689999999999999999732789889999999999999985045 Q Ver_Hs_NP_0572 121 ILDGDLYHKGLLKFSLDAVSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEP 200 (523) Q Consensus 121 iLdg~~~~~~LLK~aLt~~si~~TLVvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~ep 200 (523) ++|-+ +|..+++..+.--+..+..|+++ |-.+-+ ++|-++-+.+++ T Consensus 81 iiDtP-GH~dfi~nmi~Gas~aD~ailVV-da~~G~--~~QT~eh~~l~~------------------------------ 126 (208) T cd04166 81 IADTP-GHEQYTRNMVTGASTADLAILLV-DARKGV--LEQTRRHSYILS------------------------------ 126 (208) T ss_pred EEECC-CHHHHHHHHHHHHHHHCEEEEEE-ECCCCH--HHHHHHHHHHHH------------------------------ T ss_conf 98467-73788999998631405478898-757442--567999999999------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC-EEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC Q ss_conf 556666553445676667765344788876230058832-7998507412555542057747899999999999999718 Q Ver_Hs_NP_0572 201 GEDFPASPQRRNTASQEDKDDSVVVPLGADTLTHNLGIP-VLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYG 279 (523) Q Consensus 201 g~d~~~s~~~~~~~~~~~~d~~v~lPLgeg~Lt~NLGiP-ivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YG 279 (523) -||++ |+|+++|.|.+ +|+++.|+.|..-+..|+-+.| T Consensus 127 ----------------------------------~lgv~~iivavNK~D~v-------~~~~~r~~~i~~~~~~~l~~~~ 165 (208) T cd04166 127 ----------------------------------LLGIRHVVVAVNKMDLV-------DYSEEVFEEIVADYLAFAAKLG 165 (208) T ss_pred ----------------------------------HHCCCCEEEEEECCCCC-------CCCHHHHHHHHHHHHHHHHHCC T ss_conf ----------------------------------70799179998535666-------8898999999999999998628 Q ss_pred -CEEEE--ECCCCHHHH Q ss_conf -76888--326636789 Q Ver_Hs_NP_0572 280 -AALIY--TSVKENKNI 293 (523) Q Consensus 280 -AaLiY--TS~ke~knl 293 (523) ....| .|...-.|+ T Consensus 166 ~~~~~~iPiSa~~G~Ni 182 (208) T cd04166 166 IEDITFIPISALDGDNV 182 (208) T ss_pred CCCCEEEECCCCCCCCC T ss_conf 99823886225568845 No 100 >cd04148 RGK RGK subfamily. The RGK (Rem, Rem2, Rad, Gem/Kir) subfamily of Ras GTPases are expressed in a tissue-specific manner and are dynamically regulated by transcriptional and posttranscriptional mechanisms in response to environmental cues. RGK proteins bind to the beta subunit of L-type calcium channels, causing functional down-regulation of these voltage-dependent calcium channels, and either termination of calcium-dependent secretion or modulation of electrical conduction and contractile function. Inhibition of L-type calcium channels by Rem2 may provide a mechanism for modulating calcium-triggered exocytosis in hormone-secreting cells, and has been proposed to influence the secretion of insulin in pancreatic beta cells. RGK proteins also interact with and inhibit the Rho/Rho kinase pathway to modulate remodeling of the cytoskeleton. Two characteristics of RGK proteins cited in the literature are N-terminal and C-terminal extensions beyond the GTPase domain typical of Ra Probab=98.06 E-value=2.2e-05 Score=53.80 Aligned_columns=166 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHH----HHCCCCCCCCCCEEEEEECCCHHCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHH Q ss_conf 889736997678999997----4201468886521456404500004325246368658624324555678700266645 Q Ver_Hs_NP_0572 70 VLLLGEDGAGKTSLIRKI----QGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTL 145 (523) Q Consensus 70 ILvLG~~~sGKTtLl~~L----q~~e~~kKg~gLeY~Yl~V~DeDrdd~ar~~vWiLdg~~~~~~LLK~aLt~~si~~TL 145 (523) |++||+.++|||+|+.++ ...+.+.-.-+.+|.--.|.=+ .....+-+|-..|-..+....-.--.+.-+ T Consensus 3 IvllGd~~VGKTSLi~rf~~~~f~~~~y~~t~~~~~~~k~i~vd--g~~~~l~i~Dt~gqe~~~~~~~~~~~ada~---- 76 (221) T cd04148 3 VVMLGSPGVGKSSLASQFTSGEYDDHAYDASGDDDTYERTVSVD--GEESTLVVIDHWEQEMWTEDSCMQYQGDAF---- 76 (221) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEC--CEEEEEEEEECCCCHHHHHHHHHHHCCCEE---- T ss_conf 89981798428899888751853575556541011248999987--826799987468811467777754256718---- Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 56554010136899999999999999997327898899999999999999850455566665534456766677653447 Q Ver_Hs_NP_0572 146 VMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVV 225 (523) Q Consensus 146 VvIvlDmS~PWt~m~qL~~Wi~vLrehi~~L~i~~ee~ke~~e~~i~~~q~y~epg~d~~~s~~~~~~~~~~~~d~~v~l 225 (523) +||-|.+...+| +.+++|+..+++.-..-.+ T Consensus 77 -ilVYditdr~SF-e~v~~~~~~l~~~~~~~~v----------------------------------------------- 107 (221) T cd04148 77 -VVVYSVTDRSSF-ERASELRIQLRRNRQLEDR----------------------------------------------- 107 (221) T ss_pred -EEEEECCCHHHH-HHHHHHHHHHHHHCCCCCC----------------------------------------------- T ss_conf -999851687899-9999999999973189982----------------------------------------------- Q ss_pred CCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHC Q ss_conf 88876230058832799850741255554205774789999999999999971876888326636789999999998760 Q Ver_Hs_NP_0572 226 PLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFFQSHIRKFCLRYGAALIYTSVKENKNIDLVYKYIVQKLY 305 (523) Q Consensus 226 PLgeg~Lt~NLGiPivVVctKsD~ie~LEKe~~y~dE~fDfIqq~LR~icL~YGAaLiYTS~ke~knl~LLykYl~HrLy 305 (523) ||++|.+|+|. .++..+=..--+.++-++|+..|=||+|.+.|++-+...|+--+. T Consensus 108 -------------piILVGNK~DL-----------~~~R~Vs~eeg~~~A~~~~~~F~EtSAk~~~NV~ElFe~lvrqir 163 (221) T cd04148 108 -------------PIILVGNKSDL-----------ARSREVSVQEGRACAVVFDCKFIETSAGLQHNVDELLEGIVRQIR 163 (221) T ss_pred -------------EEEEECCCCCH-----------HHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -------------89997055353-----------241678889999999965997999851568988899999999986 Q ss_pred CCCCCCCCC Q ss_conf 655565564 Q Ver_Hs_NP_0572 306 GFPYKIPAV 314 (523) Q Consensus 306 gfpf~~~a~ 314 (523) .-+-+...+ T Consensus 164 l~~~~~~~~ 172 (221) T cd04148 164 LRRDSKEKN 172 (221) T ss_pred CCCCCCCCC T ss_conf 047887551 Done!