Query Fun_An_XP_001391598.1 Command /cluster/toolkit/production/bioprogs/hhpred/hhsearch -cpu 4 -v 1 -i /cluster/toolkit/production/tmp/production/96222/c_XP_001391598.hhm -d /cluster/toolkit/production/databases/hhpred/new_dbs/pfam_18Apr07/db//pfam.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/smart_18Apr07/db/smart.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/KOG_18Apr07/db/KOG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/COG_18Apr07/db/COG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/cd_18Apr07/db/cd.hhm -o /cluster/toolkit/production/tmp/production/96222/c_XP_001391598.hhr -p 20 -P 20 -Z 100 -B 100 -seq 1 -aliw 80 -local -ssm 2 -norealign -sc 1 No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 pfam05783 DLIC Dynein light in 100.0 0 0 986.6 27.8 414 13-523 11-436 (475) 2 KOG3905 Dynein light intermedi 100.0 0 0 911.1 27.8 398 21-523 24-434 (473) 3 KOG3929 Uncharacterized conser 99.3 2.3E-12 1.1E-16 94.9 3.9 235 46-324 45-282 (363) 4 cd00154 Rab Rab family. Rab G 98.4 7.3E-06 3.5E-10 54.8 12.9 151 49-284 3-153 (159) 5 cd01868 Rab11_like Rab11-like. 98.2 2.8E-05 1.3E-09 51.2 12.3 155 49-289 6-161 (165) 6 cd00876 Ras Ras family. The R 98.2 2E-05 9.5E-10 52.1 11.5 152 49-286 2-154 (160) 7 cd04141 Rit_Rin_Ric Rit/Rin/Ri 98.2 2.6E-05 1.3E-09 51.4 11.8 168 49-303 5-172 (172) 8 cd04113 Rab4 Rab4 subfamily. 98.2 2.9E-05 1.4E-09 51.2 11.7 151 49-284 3-153 (161) 9 cd04122 Rab14 Rab14 subfamily. 98.1 4.3E-05 2.1E-09 50.1 11.7 152 49-286 5-157 (166) 10 cd04101 RabL4 RabL4 (Rab-like4 98.1 6.1E-05 2.9E-09 49.2 12.4 153 49-284 3-155 (164) 11 cd01866 Rab2 Rab2 subfamily. 98.1 6.9E-05 3.3E-09 48.8 12.3 152 49-286 7-159 (168) 12 cd00877 Ran Ran (Ras-related n 98.1 9.5E-05 4.5E-09 47.9 12.2 159 49-296 3-166 (166) 13 pfam00071 Ras Ras family. Incl 98.0 9.6E-05 4.6E-09 47.9 11.9 150 49-284 2-152 (162) 14 cd04140 ARHI_like ARHI subfami 98.0 0.00012 5.5E-09 47.4 12.2 153 49-284 4-156 (165) 15 cd04127 Rab27A Rab27a subfamil 98.0 0.00015 7.1E-09 46.7 12.1 160 49-289 7-173 (180) 16 cd04110 Rab35 Rab35 subfamily. 98.0 0.00019 9.2E-09 46.1 12.4 151 49-286 9-160 (199) 17 cd04119 RJL RJL (RabJ-Like) su 98.0 0.00017 8.1E-09 46.4 11.9 156 49-284 3-158 (168) 18 cd04124 RabL2 RabL2 subfamily. 97.9 0.00019 9E-09 46.1 11.9 146 49-284 3-149 (161) 19 cd04160 Arfrp1 Arfrp1 subfamil 97.9 0.00042 2E-08 44.0 13.5 162 48-286 1-162 (167) 20 cd04123 Rab21 Rab21 subfamily. 97.9 0.00029 1.4E-08 45.0 12.2 151 49-284 3-153 (162) 21 cd04159 Arl10_like Arl10-like 97.9 0.00012 5.7E-09 47.3 10.2 153 48-286 1-154 (159) 22 cd04125 RabA_like RabA-like su 97.9 0.00031 1.5E-08 44.8 12.2 150 49-284 3-153 (188) 23 cd04128 Spg1 Spg1p. Spg1p (se 97.9 0.0005 2.4E-08 43.5 13.3 155 49-284 3-157 (182) 24 cd04136 Rap_like Rap-like subf 97.9 0.00018 8.6E-09 46.2 11.0 151 49-284 4-154 (163) 25 cd04156 ARLTS1 ARLTS1 subfamil 97.9 0.00027 1.3E-08 45.1 11.6 154 49-287 2-156 (160) 26 smart00175 RAB Rab subfamily o 97.8 0.00023 1.1E-08 45.6 11.2 161 49-297 3-164 (164) 27 cd04116 Rab9 Rab9 subfamily. 97.8 0.00033 1.6E-08 44.6 12.0 153 49-284 8-162 (170) 28 cd04137 RheB Rheb (Ras Homolog 97.8 0.00038 1.8E-08 44.2 11.6 154 47-286 2-156 (180) 29 cd04139 RalA_RalB RalA/RalB su 97.8 0.00025 1.2E-08 45.3 10.5 161 49-297 3-164 (164) 30 cd04151 Arl1 Arl1 subfamily. 97.8 0.00019 9E-09 46.1 9.8 152 49-286 2-153 (158) 31 cd04115 Rab33B_Rab33A Rab33B/R 97.8 0.00061 2.9E-08 43.0 12.4 152 49-284 5-160 (170) 32 cd04117 Rab15 Rab15 subfamily. 97.8 0.00042 2E-08 44.0 11.4 154 49-288 3-157 (161) 33 cd04146 RERG_RasL11_like RERG/ 97.8 0.0004 1.9E-08 44.1 11.2 153 49-284 2-155 (165) 34 cd01862 Rab7 Rab7 subfamily. 97.7 0.00067 3.2E-08 42.7 12.0 154 49-284 3-158 (172) 35 cd04112 Rab26 Rab26 subfamily. 97.7 0.00073 3.5E-08 42.5 12.2 153 49-286 3-156 (191) 36 cd00157 Rho Rho (Ras homology) 97.7 0.00027 1.3E-08 45.2 9.9 165 48-287 2-167 (171) 37 cd04106 Rab23_lke Rab23-like s 97.7 0.00081 3.9E-08 42.2 12.3 152 49-284 3-154 (162) 38 cd01861 Rab6 Rab6 subfamily. 97.7 0.0006 2.9E-08 43.0 11.6 151 49-284 3-153 (161) 39 cd01863 Rab18 Rab18 subfamily. 97.7 0.0005 2.4E-08 43.5 11.1 155 49-288 3-157 (161) 40 cd04109 Rab28 Rab28 subfamily. 97.7 0.0017 8.1E-08 40.2 13.7 162 49-291 3-168 (215) 41 cd04152 Arl4_Arl7 Arl4/Arl7 su 97.7 0.0011 5.5E-08 41.3 12.7 154 48-285 5-162 (183) 42 cd01860 Rab5_related Rab5-rela 97.7 0.00091 4.3E-08 41.9 11.8 153 49-286 4-156 (163) 43 cd04132 Rho4_like Rho4-like su 97.7 0.0014 6.5E-08 40.8 12.6 161 47-289 1-163 (187) 44 cd01865 Rab3 Rab3 subfamily. 97.7 0.0014 6.8E-08 40.7 12.6 155 49-289 4-159 (165) 45 cd01867 Rab8_Rab10_Rab13_like 97.6 0.00047 2.3E-08 43.6 10.1 152 49-286 6-158 (167) 46 cd04138 H_N_K_Ras_like H-Ras/N 97.6 0.0014 6.8E-08 40.7 12.4 151 49-286 4-155 (162) 47 cd04155 Arl3 Arl3 subfamily. 97.6 0.00073 3.5E-08 42.5 10.9 152 48-286 16-168 (173) 48 cd04175 Rap1 Rap1 subgroup. T 97.6 0.00099 4.7E-08 41.7 11.5 153 49-286 4-156 (164) 49 smart00174 RHO Rho (Ras homolo 97.6 0.00039 1.9E-08 44.2 9.1 162 49-286 1-165 (174) 50 cd00878 Arf_Arl Arf (ADP-ribos 97.6 0.00083 4E-08 42.1 10.7 152 49-286 2-153 (158) 51 cd04121 Rab40 Rab40 subfamily. 97.6 0.0019 8.9E-08 40.0 12.4 149 49-284 9-158 (235) 52 pfam00025 Arf ADP-ribosylation 97.6 0.0016 7.7E-08 40.3 12.0 153 49-286 18-170 (176) 53 cd04108 Rab36_Rab34 Rab34/Rab3 97.6 0.0012 5.6E-08 41.2 11.3 157 49-287 3-159 (170) 54 cd04114 Rab30 Rab30 subfamily. 97.5 0.001 4.7E-08 41.6 10.5 151 49-284 10-160 (169) 55 cd01864 Rab19 Rab19 subfamily. 97.5 0.0021 1E-07 39.6 11.6 150 49-284 6-157 (165) 56 cd01869 Rab1_Ypt1 Rab1/Ypt1 su 97.4 0.0022 1.1E-07 39.5 11.0 153 49-287 5-158 (166) 57 cd04118 Rab24 Rab24 subfamily. 97.4 0.0018 8.4E-08 40.1 10.4 153 49-284 3-157 (193) 58 cd04154 Arl2 Arl2 subfamily. 97.4 0.0021 1E-07 39.7 10.5 152 48-286 16-168 (173) 59 cd04120 Rab12 Rab12 subfamily. 97.4 0.0042 2E-07 37.8 12.0 150 49-284 3-154 (202) 60 cd04143 Rhes_like Rhes_like su 97.4 0.0049 2.3E-07 37.4 12.4 170 49-295 3-173 (247) 61 cd04107 Rab32_Rab38 Rab38/Rab3 97.4 0.0076 3.6E-07 36.2 13.2 156 49-284 3-159 (201) 62 smart00173 RAS Ras subfamily o 97.3 0.0025 1.2E-07 39.1 10.7 151 49-284 5-155 (166) 63 cd04134 Rho3 Rho3 subfamily. 97.3 0.0017 8.1E-08 40.2 9.8 162 47-284 1-165 (189) 64 cd04144 Ras2 Ras2 subfamily. 97.3 0.0042 2E-07 37.8 11.7 154 49-286 2-156 (190) 65 cd04149 Arf6 Arf6 subfamily. 97.3 0.0013 6E-08 41.0 8.9 153 48-286 11-163 (168) 66 smart00177 ARF ARF-like small 97.3 0.0012 5.7E-08 41.2 8.6 152 48-286 19-171 (181) 67 cd04153 Arl5_Arl8 Arl5/Arl8 su 97.3 0.00099 4.7E-08 41.7 8.1 152 48-286 17-169 (174) 68 cd04158 ARD1 ARD1 subfamily. 97.3 0.0049 2.4E-07 37.4 11.5 152 49-286 2-154 (169) 69 cd01889 SelB_euk SelB subfamil 97.3 0.0021 9.9E-08 39.7 9.5 167 48-286 2-179 (192) 70 cd04172 Rnd3_RhoE_Rho8 Rnd3/Rh 97.2 0.0016 7.5E-08 40.4 8.7 162 49-286 8-173 (182) 71 cd00881 GTP_translation_factor 97.2 0.0036 1.7E-07 38.2 9.9 153 48-285 1-179 (189) 72 cd04105 SR_beta Signal recogni 97.1 0.0047 2.2E-07 37.5 10.0 127 47-244 1-137 (203) 73 cd01875 RhoG RhoG subfamily. 97.1 0.0045 2.2E-07 37.6 9.8 178 49-303 6-185 (191) 74 cd04173 Rnd2_Rho7 Rnd2/Rho7 su 97.1 0.0015 7.2E-08 40.5 7.4 162 49-286 4-169 (222) 75 cd04145 M_R_Ras_like M-Ras/R-R 97.1 0.013 6.3E-07 34.7 12.1 154 45-284 1-155 (164) 76 cd04150 Arf1_5_like Arf1-Arf5- 97.1 0.0067 3.2E-07 36.5 10.6 150 49-285 3-153 (159) 77 cd04176 Rap2 Rap2 subgroup. T 97.1 0.0098 4.7E-07 35.5 11.2 151 49-284 4-154 (163) 78 cd01898 Obg Obg subfamily. Th 97.0 0.0046 2.2E-07 37.5 9.4 161 49-289 3-167 (170) 79 cd04177 RSR1 RSR1 subgroup. R 97.0 0.011 5.1E-07 35.3 11.2 153 49-286 4-157 (168) 80 KOG0073 GTP-binding ADP-ribosy 97.0 0.011 5.3E-07 35.2 10.7 146 33-259 5-177 (185) 81 cd04133 Rop_like Rop subfamily 96.9 0.0074 3.5E-07 36.3 9.7 156 49-284 4-164 (176) 82 cd01883 EF1_alpha Eukaryotic e 96.9 0.0032 1.5E-07 38.6 7.5 148 48-267 1-174 (219) 83 cd01888 eIF2_gamma eIF2-gamma 96.9 0.0032 1.5E-07 38.5 7.4 170 48-286 2-192 (203) 84 cd04147 Ras_dva Ras-dva subfam 96.9 0.019 8.8E-07 33.8 11.2 151 49-284 2-154 (198) 85 cd01895 EngA2 EngA2 subfamily. 96.8 0.024 1.1E-06 33.1 11.6 158 48-285 4-167 (174) 86 cd04111 Rab39 Rab39 subfamily. 96.8 0.025 1.2E-06 33.0 11.7 152 49-284 5-157 (211) 87 cd01892 Miro2 Miro2 subfamily. 96.8 0.012 5.7E-07 35.0 10.0 150 48-284 6-157 (169) 88 cd04129 Rho2 Rho2 subfamily. 96.8 0.019 9.2E-07 33.7 11.0 162 49-286 4-166 (187) 89 cd01891 TypA_BipA TypA (tyrosi 96.8 0.011 5E-07 35.3 9.5 149 47-285 3-184 (194) 90 cd01893 Miro1 Miro1 subfamily. 96.7 0.025 1.2E-06 33.0 11.1 153 49-286 3-157 (166) 91 cd01870 RhoA_like RhoA-like su 96.7 0.042 2E-06 31.6 12.0 158 47-284 2-166 (175) 92 cd04102 RabL3 RabL3 (Rab-like3 96.7 0.01 4.9E-07 35.4 8.8 140 49-239 3-143 (202) 93 cd00882 Ras_like_GTPase Ras-li 96.5 0.042 2E-06 31.6 11.0 152 51-286 1-153 (157) 94 cd04165 GTPBP1_like GTPBP1-lik 96.5 0.035 1.7E-06 32.1 10.6 178 48-297 1-224 (224) 95 cd04135 Tc10 TC10 subfamily. 96.5 0.025 1.2E-06 33.0 9.7 161 49-284 3-165 (174) 96 cd04142 RRP22 RRP22 subfamily. 96.5 0.096 4.6E-06 29.4 12.6 165 49-289 3-170 (198) 97 cd04126 Rab20 Rab20 subfamily. 96.3 0.044 2.1E-06 31.5 10.1 156 49-284 3-181 (220) 98 cd04162 Arl9_Arfrp2_like Arl9/ 96.3 0.016 7.8E-07 34.2 7.8 107 49-236 2-110 (164) 99 cd00879 Sar1 Sar1 subfamily. 96.2 0.012 5.7E-07 35.0 6.9 121 46-244 19-139 (190) 100 cd01896 DRG The developmentall 96.2 0.029 1.4E-06 32.6 8.8 202 48-297 2-233 (233) No 1 >pfam05783 DLIC Dynein light intermediate chain (DLIC). This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo. Probab=100.00 E-value=0 Score=986.60 Aligned_columns=414 Identities=31% Q ss_pred CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC--CCC-EEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 4668887777777502377898887664048--842-0478864779873212323311112455663122565674444 Q Fun_An_XP_0013 13 GTGNNSRPSSKDGPKKNIWSSMLDSVANGKR--LPE-KNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVAN 89 (523) Q Consensus 13 ~~~~~~~~~~~d~~k~nLWssiL~~vss~~r--lps-KnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~ 89 (523) ..+.....-+.+++|||||+|||++|++++| ||+ |||||||++++||||||++|++.+ +.+||+ T Consensus 11 ~~~~~~~~~~~~~~k~nLWsSIL~~V~t~~r~Klp~~KniLVLG~~~~GKttLl~~Lqg~~-------~~kkg~------ 77 (475) T pfam05783 11 ASVFTGKLYSSTEEGQNLWSEILSEVSTRTRSKLPSGKNVLVLGDNGSGKTSLISRLQGSE-------RTKKGR------ 77 (475) T ss_pred HHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCC-------CCCCCC------ T ss_conf 3320267777410122478988865302533347776647885089975578999750577-------667863------ Q ss_pred CCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH Q ss_conf 33420223310006774551101678717887112320011058101200334333000031368999999999999998 Q Fun_An_XP_0013 90 QFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVL 169 (523) Q Consensus 90 ~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi 169 (523) ||||+|+||+|+|+|| ++||+|||| ++++||++||||||+++||+||||||+|||++||+||+||++|++|||+|+ T Consensus 78 --aL~Y~YldV~DeD~Dd-~~R~~vwiL-d~~~~~~~LLK~aL~~~si~~TlViI~lDms~PW~~i~qL~~Wi~VLrehi 153 (475) T pfam05783 78 --GLEYLYLHVHDEDRDD-LTRCNVWIL-DGDLYHKGLLKFALPATSLAETLVILTASMSNPWTLLESLQKWASVLREHI 153 (475) T ss_pred --CCCEEEECCCCCCHHH-HCCCCEEEC-CCCCCCCCCCCCCCCCCCHHHHHEHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_conf --1013463232203032-215424760-875152223212577231422012001212013489999999999999999 Q ss_pred HHCC---CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC-----CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHH Q ss_conf 5069---5888999999999862268876777776777766-----4532136888753267895079996187556788 Q Fun_An_XP_0013 170 ISLD---DETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS-----AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKL 241 (523) Q Consensus 170 ~sL~---~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s-----~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~L 241 (523) ++|+ ++.+++|+++|+.||+|+++++..++.++++++. +++|.||||||+||+||||||||||||||+|++| T Consensus 154 ~~L~i~~ee~~el~e~l~~~wqeY~epg~~~d~s~~r~t~~~~~~~~~~v~lPLgeg~Lt~NLGiPiiVVctKsD~ie~L 233 (475) T pfam05783 154 DKLKIPPEEMKAGRQKLEKDWQEYVEPGEDLDGSPQRRTSVVGSFDEEHVLLPLGQDTLTHNLGLPVLVVCTKCDAMSVL 233 (475) T ss_pred HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEEEEECCCHHHHH T ss_conf 71389988999999999999998605534678776324566565344456577887634127882699986176213333 Q ss_pred HHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHCCCCCCC-CCCCCCCCCCCCCEEEECCCCCHHH Q ss_conf 863588556899999999999987184125521233210345655322532246-6755112311462457468988214 Q Fun_An_XP_0013 242 EKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSSLGIHSLL-KRQSLKHNVIDRDKILVPSNWDSWG 320 (523) Q Consensus 242 EKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~lgih~ll-~~~~~~a~vverDav~VPaGWDsw~ 320 (523) |||||||||||||||||||||||||||||||||+|+++|| +|+|+|+ +|++| +.+..+++|||||+||||||||||| T Consensus 234 EKe~~ykeE~fDfIqq~LR~~cLqYGAsLiYTS~ke~kNl-dlLykYl-~HrlYgfpf~~~a~VvekDaIfIPsGWDn~k 311 (475) T pfam05783 234 EKEHDYRDEHFDFIQSHLRKFCLQYGAALIYTSVKETKNI-DLLYKYI-VHRSYGFPFTTPALVVEKDAVFIPAGWDNEK 311 (475) T ss_pred HCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCH-HHHHHHH-HHHHHCCCCCCCCCEEEHHEEEECCCCCCHH T ss_conf 2015664367999999999999870975898547764238-9999999-9886076545622001000034058888145 Q ss_pred HEEEECCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCCCCCCE Q ss_conf 10220047660212121221201341001577655566766555566653201000211047877632222100025650 Q Fun_An_XP_0013 321 KIRIIREGFDMEGISTAWSIEIQDPPEPLTNGVDDRSSDEQTANAVDDGTSAVAIFEQTIQDPKRDTSMALTGSQRNGNK 400 (523) Q Consensus 321 KI~IL~E~Fd~~~v~~~Ws~d~~~p~~~~~~~~~d~~~~~~~~~~~~d~~sa~~~ye~~I~dP~~~~~~~~~~~~~~~~~ 400 (523) ||+|||||| ....++|. ||++|.+|++++.+|.. T Consensus 312 KI~Il~Enf--------------------------------~~~k~~~~------~ed~i~kp~~rk~~~~~-------- 345 (475) T pfam05783 312 KIDILHENF--------------------------------PTVKAEDA------YEDIITKPPVRKVVHEK-------- 345 (475) T ss_pred HHHHHHCCC--------------------------------CCCCCCCC------CCCCCCCCCCHHHHHHH-------- T ss_conf 567543365--------------------------------43578764------22344788402333333-------- Q ss_pred EEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCCC Q ss_conf 24304733889999999999843788620024667876677766777643235750221465223531676620001467 Q Fun_An_XP_0013 401 IEVDTSDMQSFLTKQLEVLEQLKAEDEKDRAAKKVPQLEMSPLDDNGRVNEHIGPVQFNMGGIQVDADDMLRKLKEREAS 480 (523) Q Consensus 401 iev~t~D~Q~FL~kQ~~iL~~~~~~~~~~~~~~~~~~~~~sp~~~~~~v~e~iGPvqfnmGGiqvdad~~l~rlk~r~a~ 480 (523) ||++||+|+||+|||++|.+ +.+....+|.++++.-+-++.| |.....++ T Consensus 346 -ei~aeddQ~Fl~k~q~~l~~------------~~~~~~~~~~~~~~~~~p~~~~-----------------~~~~~~~~ 395 (475) T pfam05783 346 -EIEAEDDQAFLMKLQSILAK------------QPTTAAPRPLRSQGVGSPRTMP-----------------RTPGTVGQ 395 (475) T ss_pred -HHCCCHHHHHHHHHHHHHCC------------CCCCCCCCCCCCCCCCCCCCCC-----------------CCCCCCCC T ss_conf -20001278999999999716------------7877777755677788874577-----------------45542366 Q ss_pred CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC Q ss_conf 7888777666778875317899999986503888886788889 Q Fun_An_XP_0013 481 RSQRKETLSSSAGDEKAHNQALANFFAGLVKKPGASPRGSPSA 523 (523) Q Consensus 481 ~s~~~~~~~~~~~~~~~~n~~LanFF~~Ll~k~~~s~rg~p~~ 523 (523) .+|.+-..+...+.... .++||||||+||+||+||| |+|+. T Consensus 396 ~~p~kk~dp~~~~~~~~-egvlanffnsll~kk~~sp-~~~~~ 436 (475) T pfam05783 396 SSPTKKIDPNLKATAGS-EGVLANFFNSLLSKKTGSP-GKPGP 436 (475) T ss_pred CCCCCCCCCCCCCCCCC-CHHHHHHHHHHHHCCCCCC-CCCCC T ss_conf 67764667775788643-1157777776630357888-88888 No 2 >KOG3905 Dynein light intermediate chain [Cell motility] Probab=100.00 E-value=0 Score=911.09 Aligned_columns=398 Identities=31% Q ss_pred CCCCCCHHHHHHHHHHHHHHHCC--CCC-EEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE Q ss_conf 77777502377898887664048--842-047886477987321232331111245566312256567444433420223 Q Fun_An_XP_0013 21 SSKDGPKKNIWSSMLDSVANGKR--LPE-KNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTY 97 (523) Q Consensus 21 ~~~d~~k~nLWssiL~~vss~~r--lps-KnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y 97 (523) +.+++++||||++||+||+++.| ||+ |||||||++++||++||.+|++.+ +.+||+ ||||.| T Consensus 24 ~~deeegqnlWs~iLsev~T~~~sklpsgk~VlvlGdn~sGKtsLi~klqg~e-------~~Kkgs--------gLeY~y 88 (473) T KOG3905 24 STDEEEGQNLWSEILSEVSTRTRSKLPSGKNVLVLGDNGSGKTSLISKLQGSE-------TVKKGS--------GLEYLY 88 (473) T ss_pred CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCC-------CCCCCC--------CCEEEE T ss_conf 45356778999999865420123447788657997058874578988763024-------567765--------312678 Q ss_pred EEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH Q ss_conf 31000677455110167871788711232001105810120033433300003136899999999999999850695888 Q Fun_An_XP_0013 98 QDVLDADHEDTLARVSAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETK 177 (523) Q Consensus 98 ~dV~D~D~eD~~aR~svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~ 177 (523) ++|+|+||||. +||+||+| |||+||++||||||++.|+++||||+++||++||+||+||++|++|+|+||++++++++ T Consensus 89 l~V~de~RDd~-tr~~VWiL-DGd~~h~~LLk~al~ats~aetlviltasms~Pw~~lesLqkWa~Vl~ehidkl~i~~e 166 (473) T KOG3905 89 LHVHDEDRDDL-TRCNVWIL-DGDLYHKGLLKFALPATSLAETLVILTASMSNPWTLLESLQKWASVLREHIDKLKIPPE 166 (473) T ss_pred EEECCCCHHHH-HHCCCEEE-CCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHH T ss_conf 86213100446-54871487-18755521243204655615458989986575035899999999999998986258989 Q ss_pred HH---HHHHHHHHHHCCCCCCCCCCCCCCCCCC-----CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCH Q ss_conf 99---9999999862268876777776777766-----453213688875326789507999618755678886358855 Q Fun_An_XP_0013 178 IV---MEENLTEWRDRKRGMDSSSGGAQGFTSS-----AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHE 249 (523) Q Consensus 178 ~~---mee~~~~~~e~~~~~~~~~~~~~~~~~s-----~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykd 249 (523) ++ +++..+.||+|+++++..+.+++++++. |+++.||||+++||||||||++|||||||+|++|||||+||| T Consensus 167 e~ka~rqk~~k~wQeYvep~e~~pgsp~~r~t~~~~~~de~~llPL~~dtLt~NlGi~vlVV~TK~D~~s~leke~eyrD 246 (473) T KOG3905 167 EMKAGRQKLEKDWQEYVEPGEDQPGSPQRRTTVVGSSADEHVLLPLGQDTLTHNLGIPVLVVCTKCDAVSVLEKEHEYRD 246 (473) T ss_pred HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEEEECCCHHHHHHHCCCCCH T ss_conf 99999999888889760512478888620343335655311112267762000068747999842430334552010016 Q ss_pred HHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHCC--CCCCCCCCCCCCCCCCCCEEEECCCCCHHHHEEEECC Q ss_conf 68999999999999871841255212332103456553225--3224667551123114624574689882141022004 Q Fun_An_XP_0013 250 EQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSSLG--IHSLLKRQSLKHNVIDRDKILVPSNWDSWGKIRIIRE 327 (523) Q Consensus 250 E~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~lg--ih~ll~~~~~~a~vverDav~VPaGWDsw~KI~IL~E 327 (523) |||||||||||+|||+|||+|||||+||.||+ +|+|+|+. ++.+.|+.| |.|||||||||||||||.|||.|||| T Consensus 247 ehfdfiq~~lRkFCLr~GaaLiyTSvKE~KNi-dllyKYivhr~yG~~fttp--AlVVEkdaVfIPAGWD~eKKI~Il~E 323 (473) T KOG3905 247 EHFDFIQSHLRKFCLRYGAALIYTSVKETKNI-DLLYKYIVHRSYGFPFTTP--ALVVEKDAVFIPAGWDNEKKIDILHE 323 (473) T ss_pred HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCH-HHHHHHHHHHHCCCCCCCH--HHEEECCEEEECCCCCCCCHHHHHHC T ss_conf 78999999999999860630255411124556-8888888876415531350--01232031463046686300221000 Q ss_pred CCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCC Q ss_conf 76602121212212013410015776555667665555666532010002110478776322221000256502430473 Q Fun_An_XP_0013 328 GFDMEGISTAWSIEIQDPPEPLTNGVDDRSSDEQTANAVDDGTSAVAIFEQTIQDPKRDTSMALTGSQRNGNKIEVDTSD 407 (523) Q Consensus 328 ~Fd~~~v~~~Ws~d~~~p~~~~~~~~~d~~~~~~~~~~~~d~~sa~~~ye~~I~dP~~~~~~~~~~~~~~~~~iev~t~D 407 (523) || ..+..+|. ||++|.+|++++.+|.. ||++|| T Consensus 324 n~--------------------------------~~vkaed~------y~d~itkpp~Rk~v~ek---------ei~aEd 356 (473) T KOG3905 324 NF--------------------------------PTVKAEDN------YEDIITKPPVRKVVHEK---------EIEAED 356 (473) T ss_pred CC--------------------------------CCCCCCCC------CCCCCCCCCCHHHHHHH---------HHHHHH T ss_conf 35--------------------------------67787765------33243688401566666---------541013 Q ss_pred HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCC Q ss_conf 38899999999998437886200246678766777667776432357502214652235316766200014677888777 Q Fun_An_XP_0013 408 MQSFLTKQLEVLEQLKAEDEKDRAAKKVPQLEMSPLDDNGRVNEHIGPVQFNMGGIQVDADDMLRKLKEREASRSQRKET 487 (523) Q Consensus 408 ~Q~FL~kQ~~iL~~~~~~~~~~~~~~~~~~~~~sp~~~~~~v~e~iGPvqfnmGGiqvdad~~l~rlk~r~a~~s~~~~~ 487 (523) +|+||+|||+||.+.+.......-..+.+..+.|| |...|..+.||-+.+ T Consensus 357 dQaFL~k~q~iLak~~~t~a~rp~~sq~~~~~ksp------------------------------rtpg~~g~sSP~k~~ 406 (473) T KOG3905 357 DQAFLMKLQSILAKQPTTAAPRPRTSQERGPDKSP------------------------------RTPGRSGSSSPLKKS 406 (473) T ss_pred HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC------------------------------CCCCCCCCCCCCCCC T ss_conf 78999999998605888888786546788878887------------------------------678887666788888 Q ss_pred CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC Q ss_conf 666778875317899999986503888886788889 Q Fun_An_XP_0013 488 LSSSAGDEKAHNQALANFFAGLVKKPGASPRGSPSA 523 (523) Q Consensus 488 ~~~~~~~~~~~n~~LanFF~~Ll~k~~~s~rg~p~~ 523 (523) .+.+.+ .||||||+||+||+||| |+|-| T Consensus 407 ~P~seg-------Vlasffnsll~kktgsp-g~~g~ 434 (473) T KOG3905 407 DPTSEG-------VLASFFNSLLSKKTGSP-GGPGA 434 (473) T ss_pred CCHHHH-------HHHHHHHHHHHHCCCCC-CCCCC T ss_conf 850246-------78999998864126888-88888 No 3 >KOG3929 Uncharacterized conserved protein [Function unknown] Probab=99.25 E-value=2.3e-12 Score=94.91 Aligned_columns=235 Identities=20% Q ss_pred CEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECC-CCCCCCEEEEEEECCCCHHH Q ss_conf 20478864779873212323311112455663122565674444334202233100067-74551101678717887112 Q Fun_An_XP_0013 46 EKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDAD-HEDTLARVSAYLLSEPSLSF 124 (523) Q Consensus 46 sKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D-~eD~~aR~svyiL~d~d~~~ 124 (523) +..|+++|-.+- ++++-.-= +|.+-+.+| -.+|||+|---.--. -.|. .|+|-| .|.... T Consensus 45 E~~I~~~Gn~~~--tt~I~~~F----------dR~e~~~~p---tlaLEYtygRR~~g~~~kdi---aN~WEL-Ggg~~~ 105 (363) T KOG3929 45 EFFIGSKGNGGK--TTIILRCF----------DRDEPPKPP---TLALEYTYGRRAKGHNPKDI---ANFWEL-GGGTSL 105 (363) T ss_pred HCEEEEECCCCE--EEEEEECC----------CCCCCCCCC---CEEEEEHHHHHHCCCCCHHH---HHHHHC-CCCCCH T ss_conf 205677338850--66533005----------765678997---21221012344147885145---655532-673246 Q ss_pred HHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC Q ss_conf 32001105810120033433300003136899999999999999850695888999999999862268876777776777 Q Fun_An_XP_0013 125 APLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGF 204 (523) Q Consensus 125 ~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~ 204 (523) ..||---.+-.++.-..+|++||||+|--+--.+.+-..-+|.|++.+..-...+.-++....+.|...--..+.+ T Consensus 106 ~~LLsVPit~~~l~~~slIL~LDls~p~~~W~t~E~~~~~~R~~vd~~~~~~~k~~~~L~E~mrqR~~~rvgqd~~---- 181 (363) T KOG3929 106 LDLLSVPITGDTLRTFSLILVLDLSKPNDLWPTMENLLQATRSHVDKVIMKLGKTNAKLVEEMRQRIWNRVGQDHP---- 181 (363) T ss_pred HHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC---- T ss_conf 8886055455628775666765115624432579999999998999999987414889999999999986214687---- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 76645321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 205 TSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 205 ~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .-++-+++.+|++.|..|-|-..-.|-|+.- -+-|+||-..--|||+|.+-|.+-++-. .+ T Consensus 182 ------------d~e~~dP~P~PV~IVgsKYDvFq~FesekRk------H~C~~LRf~Ah~yGaaLlmfSskMe~l~-K~ 242 (363) T KOG3929 182 ------------DHELIDPFPVPVVIVGSKYDVFQDFESEKRK------HICKTLRFVAHYYGAALLMFSSKMEALL-KK 242 (363) T ss_pred ------------CCCCCCCCCCCEEEECCCCHHHCCCCHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-HH T ss_conf ------------4000277885347853520001266367899------9999999999997789999888789999-99 Q ss_pred HHHHCCCCCCCCCCCCC--CCCCCCCEEEECCCCCHHHHEEE Q ss_conf 55322532246675511--23114624574689882141022 Q Fun_An_XP_0013 285 IHSSLGIHSLLKRQSLK--HNVIDRDKILVPSNWDSWGKIRI 324 (523) Q Consensus 285 lh~~lgih~ll~~~~~~--a~vverDav~VPaGWDsw~KI~I 324 (523) +.-. |.-+-|..+.. +-|-----.||-+|.|||++|++ T Consensus 243 ir~~--i~HlaFG~~~~~s~~vD~NkPlfi~~G~DS~~~IG~ 282 (363) T KOG3929 243 IRGV--INHLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGS 282 (363) T ss_pred HHHH--HHHHHCCCCCCCCEEEECCCCEEEEECCCCHHHCCC T ss_conf 8777--775404765766545307874589855532233378 No 4 >cd00154 Rab Rab family. Rab GTPases form the largest family within the Ras superfamily. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. Rab GTPases are small, monomeric proteins that function as molecular switches to regulate vesicle trafficking pathways. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they regulate distinct steps in membrane traffic pathways. In the GTP-bound form, Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide di Probab=98.41 E-value=7.3e-06 Score=54.82 Aligned_columns=151 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+-.. +....- +..|....+.-.+.. .++.+|=. .|.-.+..+. T Consensus 3 i~ivG~~~vGKTsli~~~~~~~f~~----~~~~Ti--------~~~~~~k~i~~~~~~---~~~~i~Dt-~g~e~~~~~~ 66 (159) T cd00154 3 IVLIGDSGVGKTSLLLRFVDGKFDE----NYKSTI--------GVDFKSKTIEIDGKT---VKLQIWDT-AGQERFRSIT 66 (159) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCC--------CEEEEEEEEEECCEE---EEEEEEEC-CCCHHHHHHH T ss_conf 8998269966899999986382474----446531--------003688899888959---99999865-9971456777 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.- --.++|+.|++++.++ +.+++|+..+++... T Consensus 67 ~~~~~~----~d~~iiv~d~~~~~Sf-~~i~~~~~~i~~~~~-------------------------------------- 103 (159) T cd00154 67 PSYYRG----AHGAILVYDITNRESF-ENLDKWLKELKEYAP-------------------------------------- 103 (159) T ss_pred HHHCCC----CCEEEEEEECCCHHHH-HHHHHHHHHHHHHCC-------------------------------------- T ss_conf 875148----9869999866997899-999999999998269-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) -++|+++|++|+| |+.++.-..|+ .|.+|-++++..|.||.+...|.+.| T Consensus 104 ---------------~~~piiivgnK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~e~Sa~~~~~i~~~ 153 (159) T cd00154 104 ---------------ENIPIILVGNKID----LEDQRQVSTEE-------AQQFAKENGLLFFETSAKTGENVEEL 153 (159) T ss_pred ---------------CCCEEEEEECCCC----HHHHCCCCHHH-------HHHHHHHCCCCEEEEEECCCCCHHHH T ss_conf ---------------9978999841310----00102656889-------99999965996999970479887899 No 5 >cd01868 Rab11_like Rab11-like. Rab11a, Rab11b, and Rab25 are closely related, evolutionary conserved Rab proteins that are differentially expressed. Rab11a is ubiquitously synthesized, Rab11b is enriched in brain and heart and Rab25 is only found in epithelia. Rab11/25 proteins seem to regulate recycling pathways from endosomes to the plasma membrane and to the trans-Golgi network. Furthermore, Rab11a is thought to function in the histamine-induced fusion of tubulovesicles containing H+, K+ ATPase with the plasma membrane in gastric parietal cells and in insulin-stimulated insertion of GLUT4 in the plasma membrane of cardiomyocytes. Overexpression of Rab25 has recently been observed in ovarian cancer and breast cancer, and has been correlated with worsened outcomes in both diseases. In addition, Rab25 overexpression has also been observed in prostate cancer, transitional cell carcinoma of the bladder, and invasive breast tumor cells. GTPase activating proteins (GAPs) interact with GTP Probab=98.22 E-value=2.8e-05 Score=51.20 Aligned_columns=155 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+-.. +..- -+|..|....= ..++....+.+|=.+..+.+ T Consensus 6 i~~iG~~~VGKTsli~r~~~~~F~~----~~~~----------Tig~~~~~k~v-~~~~~~~~l~iwDtaG~e~~----- 65 (165) T cd01868 6 IVLIGDSGVGKSNLLSRFTRNEFNL----DSKS----------TIGVEFATRSI-QIDGKTIKAQIWDTAGQERY----- 65 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEEE-EECCEEEEEEEECCCCCHHH----- T ss_conf 9998269965899999986385674----5564----------10012468898-64890899998538986124----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .++|+-|.+.+.+| +.+.+|+..++++..+ T Consensus 66 -~~~~~~~~~~a~~~iivyDit~~~Sf-~~i~~w~~~i~~~~~~------------------------------------ 107 (165) T cd01868 66 -RAITSAYYRGAVGALLVYDITKKQTF-ENVERWLKELRDHADS------------------------------------ 107 (165) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -57767650488679999746997789-9999999999983289------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|+++|.+|+| |+..+.... +-.+.+|.++|+..|-||++...|.+.+.+. T Consensus 108 -----------------~~piilVGNK~D----L~~~r~v~~-------~e~~~~a~~~~~~~~e~Sak~g~ni~~~F~~ 159 (165) T cd01868 108 -----------------NIVIMLVGNKSD----LRHLRAVPT-------EEAKAFAEKNGLSFIETSALDGTNVEEAFKQ 159 (165) T ss_pred -----------------CCEEEEEECCCC----HHHCCCCCH-------HHHHHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------937999821656----212037768-------8999999965994999971479888899999 Q ss_pred HC Q ss_conf 22 Q Fun_An_XP_0013 288 SL 289 (523) Q Consensus 288 ~l 289 (523) .. T Consensus 160 l~ 161 (165) T cd01868 160 LL 161 (165) T ss_pred HH T ss_conf 99 No 6 >cd00876 Ras Ras family. The Ras family of the Ras superfamily includes classical N-Ras, H-Ras, and K-Ras, as well as R-Ras, Rap, Ral, Rheb, Rhes, ARHI, RERG, Rin/Rit, RSR1, RRP22, Ras2, Ras-dva, and RGK proteins. Ras proteins regulate cell growth, proliferation and differentiation. Ras is activated by guanine nucleotide exchange factors (GEFs) that release GDP and allow GTP binding. Many RasGEFs have been identified. These are sequestered in the cytosol until activation by growth factors triggers recruitment to the plasma membrane or Golgi, where the GEF colocalizes with Ras. Active GTP-bound Ras interacts with several effector proteins: among the best characterized are the Raf kinases, phosphatidylinositol 3-kinase (PI3K), RalGEFs and NORE/MST1. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of m Probab=98.22 E-value=2e-05 Score=52.14 Aligned_columns=152 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+-.. ++.. ..+-.| ...-..++...++.+|=. .|...+ T Consensus 2 i~~iGd~~vGKTsli~r~~~~~f~~----~~~~----------ti~~~~--~k~~~~~~~~~~l~i~Dt-~G~e~~---- 60 (160) T cd00876 2 VVVLGAGGVGKSAITIQFVKGTFVE----EYDP----------TIEDSY--RKTIVVDGETYTLDILDT-AGQEEF---- 60 (160) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CHHHEE--EEEEEECCEEEEEEEEEC-CCCHHH---- T ss_conf 7888079966899999987281067----5354----------200226--778888482899998635-884133---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..+++. .++|+.|-+.+.+| +.+++|...+++....- T Consensus 61 -~~~~~~~~~~a~~~iivfdi~~~~Sf-~~i~~w~~~i~~~~~~~----------------------------------- 103 (160) T cd00876 61 -SAMRDLYIRQGDGFILVYSITDRESF-EEIKGYREQILRVKDDE----------------------------------- 103 (160) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCCC----------------------------------- T ss_conf -46888764046178999866997799-99999999999853899----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|+++|++|+| |..++-...++ .+.|+-++|+..|.||++...|...+.. T Consensus 104 -----------------~~piilvgNK~D----l~~~r~v~~~e-------~~~~a~~~~~~~~e~Sak~~~nV~~~F~ 154 (160) T cd00876 104 -----------------DIPIVLVGNKCD----LENERQVSKEE-------GKALAKEWGCPFIETSAKDNINIDEVFK 154 (160) T ss_pred -----------------CCEEEEEECCCC----CHHHCCCCHHH-------HHHHHHHCCCCEEEEEECCCCCHHHHHH T ss_conf -----------------967999821326----30011676889-------9999996499699997048988889999 No 7 >cd04141 Rit_Rin_Ric Rit/Rin/Ric subfamily. Rit (Ras-like protein in all tissues), Rin (Ras-like protein in neurons) and Ric (Ras-related protein which interacts with calmodulin) form a subfamily with several unique structural and functional characteristics. These proteins all lack a the C-terminal CaaX lipid-binding motif typical of Ras family proteins, and Rin and Ric contain calmodulin-binding domains. Rin, which is expressed only in neurons, induces neurite outgrowth in rat pheochromocytoma cells through its association with calmodulin and its activation of endogenous Rac/cdc42. Rit, which is ubiquitously expressed in mammals, inhibits growth-factor withdrawl-mediated apoptosis and induces neurite extension in pheochromocytoma cells. Rit and Rin are both able to form a ternary complex with PAR6, a cell polarity-regulating protein, and Rac/cdc42. This ternary complex is proposed to have physiological function in processes such as tumorigenesis. Activated Ric is likely to sign Probab=98.20 E-value=2.6e-05 Score=51.39 Aligned_columns=168 Identities=21% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+...-... ....-.|-|++.|.....+ ++...++.+|=. .|...|..|. T Consensus 5 i~liGd~~VGKTsli~rf~~~~--------F~~~y~pTi~~~~~~~i~~--------~~~~v~l~iwDt-aGqe~~~~l~ 67 (172) T cd04141 5 IVMLGAGGVGKSAVTMQFISHS--------FPDYHDPTIEDAYKQQARI--------DNEPALLDILDT-AGQAEFTAMR 67 (172) T ss_pred EEEEECCCCCHHHHHHHHHCCC--------CCCCCCCCCEEEEEEEEEE--------CCEEEEEEEECC-CCCHHHHHHH T ss_conf 9997079843899999987282--------2776566300004789989--------795899986227-7621355676 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--. .+||+-|-+++-+| +.+..|...+...-..- T Consensus 68 ~~~~~~a~----~~ilVyditd~~Sf-~~i~~w~~~i~~~~~~~------------------------------------ 106 (172) T cd04141 68 DQYMRCGE----GFIICYSVTDRHSF-QEASEFKKLITRVRLTE------------------------------------ 106 (172) T ss_pred HHHCCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHHCCCC------------------------------------ T ss_conf 87514997----38998542897689-99999999999740799------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) .+|+++|.+||| |+.++.-..++ .+.+|=++|+..|-||++...|...+.+.. T Consensus 107 ----------------~~pivlvgNK~D----L~~~r~V~~~e-------~~~~a~~~~~~f~EtSAk~~~nV~~~F~~l 159 (172) T cd04141 107 ----------------DIPLVLVGNKVD----LESQRQVTTEE-------GRNLAREFNCPFFETSAALRHYIDDAFHGL 159 (172) T ss_pred ----------------CCEEEEEECCCH----HHHCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHH T ss_conf ----------------977999815601----65415667789-------999999659969999705898878999999 Q ss_pred CCCCCCCCCCCCCCC Q ss_conf 253224667551123 Q Fun_An_XP_0013 289 LGIHSLLKRQSLKHN 303 (523) Q Consensus 289 lgih~ll~~~~~~a~ 303 (523) +..+.++++++|. T Consensus 160 --~~~i~~k~~~p~~ 172 (172) T cd04141 160 --VREIRRKESMPAL 172 (172) T ss_pred --HHHHHHHCCCCCC T ss_conf --9999971778789 No 8 >cd04113 Rab4 Rab4 subfamily. Rab4 has been implicated in numerous functions within the cell. It helps regulate endocytosis through the sorting, recycling, and degradation of early endosomes. Mammalian Rab4 is involved in the regulation of many surface proteins including G-protein-coupled receptors, transferrin receptor, integrins, and surfactant protein A. Experimental data implicate Rab4 in regulation of the recycling of internalized receptors back to the plasma membrane. It is also believed to influence receptor-mediated antigen processing in B-lymphocytes, in calcium-dependent exocytosis in platelets, in alpha-amylase secretion in pancreatic cells, and in insulin-induced translocation of Glut4 from internal vesicles to the cell surface. Rab4 is known to share effector proteins with Rab5 and Rab11. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to p Probab=98.19 E-value=2.9e-05 Score=51.16 Aligned_columns=151 Identities=13% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+...+-.. ++.. -+|..|....= +.++...++.+|=. .|.-.+..+. T Consensus 3 iviiGd~~VGKTsli~~~~~~~f~~----~~~~----------Tig~~~~~~~i-~~~~~~~~l~i~Dt-~G~e~~~~l~ 66 (161) T cd04113 3 FIIIGSSGTGKSCLLHRFVENKFKE----DSQH----------TIGVEFGSKII-RVGGKRVKLQIWDT-AGQERFRSVT 66 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CCCCCEEEEEE-EECCEEEEEEEEEC-CCCCHHHHHH T ss_conf 8998269855899999986281066----6564----------10120135899-88896999998325-8870134555 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+..-. .++|+-|.+.+.+| +.+++|+.-+|..... T Consensus 67 ~~~~~~a~----~~iivydi~~~~Sf-~~i~~w~~~~~~~~~~------------------------------------- 104 (161) T cd04113 67 RSYYRGAA----GALLVYDITNRTSF-EALPTWLSDARALASP------------------------------------- 104 (161) T ss_pred HHHCCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------- T ss_conf 86426997----79999855986689-9999999999872489------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|++||| |+.++....++ .+.+|.++|...|.||++...|.+.+ T Consensus 105 ----------------~~~iilvgNK~D----L~~~r~v~~~e-------~~~~a~~~~~~~~e~Sak~~~ni~e~ 153 (161) T cd04113 105 ----------------NIVVILVGNKSD----LADQREVTFLE-------ASRFAQENGLLFLETSALTGENVEEA 153 (161) T ss_pred ----------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHH T ss_conf ----------------968999832456----42133458899-------99999965990999971589888899 No 9 >cd04122 Rab14 Rab14 subfamily. Rab14 GTPases are localized to biosynthetic compartments, including the rough ER, the Golgi complex, and the trans-Golgi network, and to endosomal compartments, including early endosomal vacuoles and associated vesicles. Rab14 is believed to function in both the biosynthetic and recycling pathways between the Golgi and endosomal compartments. Rab14 has also been identified on GLUT4 vesicles, and has been suggested to help regulate GLUT4 translocation. In addition, Rab14 is believed to play a role in the regulation of phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GT Probab=98.13 E-value=4.3e-05 Score=50.06 Aligned_columns=152 Identities=14% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.|||+|+..+...+-.. +... -+|..|....= +.++...++.+|=.+.-+-+ T Consensus 5 ivviGd~~VGKTsli~r~~~~~f~~----~~~~----------Ti~~~~~~k~i-~~~~~~v~l~i~Dt~G~e~~----- 64 (166) T cd04122 5 YIIIGDMGVGKSCLLHQFTEKKFMA----DCPH----------TIGVEFGTRII-EVNGQKIKLQIWDTAGQERF----- 64 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CCCCEEEEEEE-EECCEEEEEEEEECCCCHHH----- T ss_conf 9998269955899998876384364----4562----------10221467888-52890899998635886023----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .++|+-|.+.+-+| +.+.+|+.-++.+... T Consensus 65 -~~~~~~~~~~a~~~ilvydit~~~Sf-~~i~~w~~~~~~~~~~------------------------------------ 106 (166) T cd04122 65 -RAVTRSYYRGAAGALMVYDITRRSTY-NHLSSWLTDARNLTNP------------------------------------ 106 (166) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHCCCC------------------------------------ T ss_conf -45538642698759998207998789-9999999999740489------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|+++|.+||| |+.++....|+ ...+|-++|+..|-||++...|...+-+ T Consensus 107 -----------------~~~iilVGNK~D----L~~~r~v~~~e-------~~~~a~~~~~~~~E~SAk~~~nV~e~F~ 157 (166) T cd04122 107 -----------------NTVIFLIGNKAD----LEAQRDVTYEE-------AKQFADENGLLFLECSAKTGENVEDAFL 157 (166) T ss_pred -----------------CCEEEEECCHHH----HHHHCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------957999637254----44303541789-------9999996499199997158988789999 No 10 >cd04101 RabL4 RabL4 (Rab-like4) subfamily. RabL4s are novel proteins that have high sequence similarity with Rab family members, but display features that are distinct from Rabs, and have been termed Rab-like. As in other Rab-like proteins, RabL4 lacks a prenylation site at the C-terminus. The specific function of RabL4 remains unknown. Probab=98.13 E-value=6.1e-05 Score=49.15 Aligned_columns=153 Identities=14% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+-||++|+..+......-...-...- +.+|....+.= +.+++ ..+.+|=. .|...+..+. T Consensus 3 vv~iGd~~VGKTsli~~~~~~~~~f~~~y~~T~----------~~~~~~~~~~i-~~~~~-~~l~i~Dt-aGqe~~~~~~ 69 (164) T cd04101 3 CAVVGDPAVGKTAFVQMFHSNGAVFPKNYLMTT----------GCDFVVKEVPV-DTDNT-VELFIFDS-AGQELYSDMV 69 (164) T ss_pred EEEEECCCCCHHHHHHHHHHCCCEECCCCCCCE----------EEEEEEEEEEE-CCCCE-EEEEEEEC-CCCHHHHHHH T ss_conf 899807982189888877616844166654311----------24567999997-79967-99999603-8722467887 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--.. ++|+-|.+++.+| +.+.+|+.-++.+-. T Consensus 70 ~~~~~~a~~----~ilvydit~~~Sf-~~i~~w~~~i~~~~~-------------------------------------- 106 (164) T cd04101 70 SNYWESPSV----FILVYDVSNKASF-ENCSRWVNKVRTASK-------------------------------------- 106 (164) T ss_pred HHHCCCCCE----EEEEEECCCHHHH-HHHHHHHHHHHHHCC-------------------------------------- T ss_conf 874249976----9999417997689-999999999998449-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|.+|+| |+..+--.+++ .+.+|-.+|+..|.||++...|...+ T Consensus 107 ----------------~~p~ilVGNK~D----L~~~r~V~~~~-------~~~~a~~~~~~~~e~SAktg~nV~e~ 155 (164) T cd04101 107 ----------------HMPGVLVGNKMD----LADKAEVTDAQ-------AQAFAQANQLKFFKTSALRGVGYEEP 155 (164) T ss_pred ----------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------973999821434----00116789899-------99999963994999971689887899 No 11 >cd01866 Rab2 Rab2 subfamily. Rab2 is localized on cis-Golgi membranes and interacts with Golgi matrix proteins. Rab2 is also implicated in the maturation of vesicular tubular clusters (VTCs), which are microtubule-associated intermediates in transport between the ER and Golgi apparatus. In plants, Rab2 regulates vesicle trafficking between the ER and the Golgi bodies and is important to pollen tube growth. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key featur Probab=98.10 E-value=6.9e-05 Score=48.80 Aligned_columns=152 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+-.. .+.-.- |.+|....|.-.+.. .++.+|=.+..+-+ T Consensus 7 ivliGd~~VGKTsli~r~~~~~f~~----~~~~Ti--------~~~~~~k~i~~~~~~---v~l~iwDt~G~e~~----- 66 (168) T cd01866 7 YIIIGDTGVGKSCLLLQFTDKRFQP----VHDLTI--------GVEFGARMITIDGKQ---IKLQIWDTAGQESF----- 66 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEECCCCCCE---EEEEEEECCCCCCH----- T ss_conf 9998169843899999985482575----445300--------000012321467842---89998753888411----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .++|+-|.+++-+| +.|..|+..++.+... T Consensus 67 -~~l~~~~~~~a~~~iivfdvt~~~Sf-~~i~~w~~~~~~~~~~------------------------------------ 108 (168) T cd01866 67 -RSITRSYYRGAAGALLVYDITRRETF-NHLTSWLEDARQHSNS------------------------------------ 108 (168) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -24536534799779999766997789-9999999999973699------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|+++|-+|+| |+.++....++ .+.+|-++|+..|-||++...|...+-+ T Consensus 109 -----------------~~piilVGnK~D----L~~~r~v~~~e-------~~~~a~~~~~~~~E~SAkt~~nV~~~F~ 159 (168) T cd01866 109 -----------------NMTIMLIGNKCD----LESRREVSYEE-------GEAFAKEHGLIFMETSAKTASNVEEAFI 159 (168) T ss_pred -----------------CCEEEEEECCHH----HHHHCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------968999833201----23304776889-------9999996598499986157988789999 No 12 >cd00877 Ran Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases. Ran GTPase is involved in diverse biological functions, such as nuclear transport, spindle formation during mitosis, DNA replication, and cell division. Among the Ras superfamily, Ran is a unique small G protein. It does not have a lipid modification motif at the C-terminus to bind to the membrane, which is often observed within the Ras superfamily. Ran may therefore interact with a wide range of proteins in various intracellular locations. Like other GTPases, Ran exists in GTP- and GDP-bound conformations that interact differently with effectors. Conversion between these forms and the assembly or disassembly of effector complexes requires the interaction of regulator proteins. The intrinsic GTPase activity of Ran is very low, but it is greatly stimulated by a GTPase-activating protein (RanGAP1) located in the cytoplasm. By contrast, RCC1, a guanine nucleotide exchange factor that generates RanGTP, is Probab=98.05 E-value=9.5e-05 Score=47.95 Aligned_columns=159 Identities=20% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+....-.. .+..-- |..+....+...+.. .++.+|=. .|...| T Consensus 3 IvliGd~~VGKTsli~r~~~~~F~~----~y~~Ti--------g~~~~~~~~~~~~~~---i~l~iwDt-aG~e~f---- 62 (166) T cd00877 3 LVLVGDGGTGKTTFVKRHLTGEFEK----KYVATL--------GVEVHPLDFHTNRGK---IRFNVWDT-AGQEKF---- 62 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCEE--------EEEEEEEEEEECCCE---EEEEEEEC-CCCCCC---- T ss_conf 8998269844899988876381166----645346--------448889999987947---99998845-785213---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) -.+.+..++++ .+|++-|.+.+++|-. +..|+.-++++.. T Consensus 63 -~~l~~~y~~~a~~~ilvfDit~~~Sf~~-i~~w~~~i~~~~~------------------------------------- 103 (166) T cd00877 63 -GGLRDGYYIGGQCAIIMFDVTSRVTYKN-VPNWHRDLVRVCG------------------------------------- 103 (166) T ss_pred -CCCCCCCCCCCCEEEEEEECCCHHHHHH-HHHHHHHHHHHCC------------------------------------- T ss_conf -5455120002675899986699789898-9889999986459------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCH----HH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103----45 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSL----QS 283 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl----~~ 283 (523) .+|+++|.+|+| |+......++. .++.++|+..|-||++...|. +. T Consensus 104 -----------------~ipivlVGNK~D----l~~~~~~~~~~---------~~~~~~~~~~~EtSAk~g~NV~e~F~~ 153 (166) T cd00877 104 -----------------NIPIVLCGNKVD----IKDRKVKAKQI---------TFHRKKNLQYYEISAKSNYNFEKPFLW 153 (166) T ss_pred -----------------CCCEEEEECCCC----CCCCCCCHHHH---------HHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------965899932677----32011248999---------999957994999970489898899999 Q ss_pred HHHHHCCCCCCCC Q ss_conf 6553225322466 Q Fun_An_XP_0013 284 LIHSSLGIHSLLK 296 (523) Q Consensus 284 Llh~~lgih~ll~ 296 (523) |+.+.|+--.|-+ T Consensus 154 la~~il~~~n~~~ 166 (166) T cd00877 154 LARKLLGNPNLEF 166 (166) T ss_pred HHHHHHCCCCCCC T ss_conf 9999853789789 No 13 >pfam00071 Ras Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices. Probab=98.03 E-value=9.6e-05 Score=47.92 Aligned_columns=150 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||++|+..+...+-.. +... -++..++ ...-..++..-.+++|=. .|.-.+ T Consensus 2 i~viG~~~vGKTsli~r~~~~~f~~----~~~~----------Ti~~~~~-~k~v~~~~~~~~l~i~Dt-~g~e~~---- 61 (162) T pfam00071 2 LVLVGDGGVGKSSLLIRFTQNKFPE----EYIP----------TIGVDFY-TKTIEVDGKTVKLQIWDT-AGQERF---- 61 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEE-EEEEEECCEEEEEEEEEC-CCCCHH---- T ss_conf 7888179966899999986383276----5442----------0101578-999987367999999866-998013---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .++|+-|.+..=+| +.+++|+..++++... T Consensus 62 -~~~~~~~~~~ad~~ilvfd~~~~~Sf-~~i~~w~~~i~~~~~~------------------------------------ 103 (162) T pfam00071 62 -RSLRPAYYRGAQGFLLVYDITSRDSF-ENVKKWLEEILRHADE------------------------------------ 103 (162) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -56758650489889999877997899-9999999999984599------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|++|+| |+.++.-..++ .+.+|-++++..|.||.+...+.+.+ T Consensus 104 -----------------~~piilvgnK~D----l~~~~~i~~~e-------~~~~~~~~~~~y~e~Sak~g~gI~e~ 152 (162) T pfam00071 104 -----------------NVPIVLVGNKCD----LEDQRVVSTEE-------GEALAKELGLPFMETSAKTNTNVEEA 152 (162) T ss_pred -----------------CCEEEEEEECCH----HHHHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf -----------------948999850420----11211676889-------99999964995999971479888899 No 14 >cd04140 ARHI_like ARHI subfamily. ARHI (A Ras homolog member I) is a member of the Ras family with several unique structural and functional properties. ARHI is expressed in normal human ovarian and breast tissue, but its expression is decreased or eliminated in breast and ovarian cancer. ARHI contains an N-terminal extension of 34 residues (human) that is required to retain its tumor suppressive activity. Unlike most other Ras family members, ARHI is maintained in the constitutively active (GTP-bound) state in resting cells and has modest GTPase activity. ARHI inhibits STAT3 (signal transducers and activators of transcription 3), a latent transcription factor whose abnormal activation plays a critical role in oncogenesis. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Due to Probab=98.03 E-value=0.00012 Score=47.43 Aligned_columns=153 Identities=12% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....-.. ++.. -++-.|.-+...+... ..+.+|=. .|...|..+. T Consensus 4 IvliGd~~VGKTsli~r~~~~~F~~----~y~~----------ti~~~~~~~i~~~~~~--~~l~i~Dt-~G~e~~~~l~ 66 (165) T cd04140 4 VVVFGAGGVGKSSLVLRFVKGTFRE----SYIP----------TIEDTYRQVISCSKNI--CTLQITDT-TGSHQFPAMQ 66 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEECEEEEEEEECCCE--EEEEEECC-CCCCCHHHHH T ss_conf 8998079965899998876282066----5454----------2001157788636948--99997037-7631023566 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--+ .+||+-|.+++.+| +.+..|...+++.-..-... T Consensus 67 ~~~~~~a~----~~ilvydit~~~Sf-~~i~~~~~~i~~~~~~~~~~--------------------------------- 108 (165) T cd04140 67 RLSISKGH----AFILVYSVTSKQSL-EELKPIYELICEIKGNNIEK--------------------------------- 108 (165) T ss_pred HHHHCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHHHCCCCCC--------------------------------- T ss_conf 88621898----58999875997788-99999999999862248898--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) +|+++|-+|+| |+.++.-..++ .+.+|-++|+..|.||++...|...+ T Consensus 109 -----------------ipiilvGNK~D----l~~~r~V~~~e-------~~~~a~~~~~~~~E~SAk~~~nv~~~ 156 (165) T cd04140 109 -----------------IPIMLVGNKCD----ESHKREVSSNE-------GAACATEWNCAFMETSAKTNHNVQEL 156 (165) T ss_pred -----------------CEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf -----------------57999503114----01046689899-------99999956995899971489887899 No 15 >cd04127 Rab27A Rab27a subfamily. The Rab27a subfamily consists of Rab27a and its highly homologous isoform, Rab27b. Unlike most Rab proteins whose functions remain poorly defined, Rab27a has many known functions. Rab27a has multiple effector proteins, and depending on which effector it binds, Rab27a has different functions as well as tissue distribution and/or cellular localization. Putative functions have been assigned to Rab27a when associated with the effector proteins Slp1, Slp2, Slp3, Slp4, Slp5, DmSlp, rabphilin, Dm/Ce-rabphilin, Slac2-a, Slac2-b, Slac2-c, Noc2, JFC1, and Munc13-4. Rab27a has been associated with several human diseases, including hemophagocytic syndrome (Griscelli syndrome or GS), Hermansky-Pudlak syndrome, and choroidermia. In the case of GS, a rare, autosomal recessive disease, a Rab27a mutation is directly responsible for the disorder. When Rab27a is localized to the secretory granules of pancreatic beta cells, it is believed to mediate glucose-stimulated Probab=97.98 E-value=0.00015 Score=46.74 Aligned_columns=160 Identities=21% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCC-------CCCCCEEEEEEECCCC Q ss_conf 788647798732123233111124556631225656744443342022331000677-------4551101678717887 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADH-------EDTLARVSAYLLSEPS 121 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~-------eD~~aR~svyiL~d~d 121 (523) |+|+|+.+.||++|+..+...+-.. .+..-- |+++..-.+.-+.. +...-.+.+|=. .|. T Consensus 7 ivviGd~~vGKTsli~r~~~~~f~~----~~~~Ti--------g~~~~~k~i~~~~~~~~~~~~~~~~v~l~iwDt-aGq 73 (180) T cd04127 7 FLALGDSGVGKTSFLYQYTDNKFNP----KFITTV--------GIDFREKRVVYNSSGPGGTLGRGQRIHLQLWDT-AGQ 73 (180) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCEE--------EEEEEEEEEEEECCCCCCCCCCCCEEEEEEEEC-CCC T ss_conf 9998069843899988876383277----635401--------113557799971255433245772799999724-776 Q ss_pred HHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC Q ss_conf 11232001105810120033433300003136899999999999999850695888999999999862268876777776 Q Fun_An_XP_0013 122 LSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGA 201 (523) Q Consensus 122 ~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~ 201 (523) -.|..+.+....--.. ++|+-|-+.+.++-. +..|+..++.+..+- T Consensus 74 e~~~~l~~~~~~~a~~----~ilvydit~~~Sf~~-~~~w~~~i~~~~~~~----------------------------- 119 (180) T cd04127 74 ERFRSLTTAFFRDAMG----FLLIFDLTNEQSFLN-VRNWMSQLQTHAYCE----------------------------- 119 (180) T ss_pred CHHHHHHHHHCCCCCE----EEEEEECCCHHHHHH-HHHHHHHHHHHCCCC----------------------------- T ss_conf 2145676886049988----999974689668899-999999998613678----------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCH Q ss_conf 77776645321368887532678950799961875567888635885568999999999999871841255212332103 Q Fun_An_XP_0013 202 QGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSL 281 (523) Q Consensus 202 ~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl 281 (523) .+|+++|++|+| |++++.-..++ .+.+|=++|+..|.||++...|. T Consensus 120 -----------------------~~~ivlVgNK~D----l~~~r~Vs~~e-------~~~~a~~~~~~~~e~SAk~~~nV 165 (180) T cd04127 120 -----------------------NPDIVLCGNKAD----LEDQRQVSEEQ-------AKALADKYGIPYFETSAATGTNV 165 (180) T ss_pred -----------------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCH T ss_conf -----------------------750788720235----52112248789-------99999965995999971479887 Q ss_pred HHHHHHHC Q ss_conf 45655322 Q Fun_An_XP_0013 282 QSLIHSSL 289 (523) Q Consensus 282 ~~Llh~~l 289 (523) ..+..... T Consensus 166 ~e~F~~l~ 173 (180) T cd04127 166 EKAVERLL 173 (180) T ss_pred HHHHHHHH T ss_conf 89999999 No 16 >cd04110 Rab35 Rab35 subfamily. Rab35 is one of several Rab proteins to be found to participate in the regulation of osteoclast cells in rats. In addition, Rab35 has been identified as a protein that interacts with nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) in human cells. Overexpression of NPM-ALK is a key oncogenic event in some anaplastic large-cell lymphomas; since Rab35 interacts with N|PM-ALK, it may provide a target for cancer treatments. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is Probab=97.96 E-value=0.00019 Score=46.06 Aligned_columns=151 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+-.+....-.. .+.--- |..|.-..|.-+++. .++.+|=.+..+-+ T Consensus 9 vv~iGd~~VGKTsli~r~~~~~F~~----~y~~Ti--------g~~~~~k~v~i~~~~---~~l~iwDtaGqe~~----- 68 (199) T cd04110 9 LLIIGDSGVGKSSLLLRFADNTFSG----SYITTI--------GVDFKIRTVEINGER---VKLQIWDTAGQERF----- 68 (199) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCCE--------EEEEEEEEEEECCEE---EEEEEEECCCCCHH----- T ss_conf 9998269843899998876180076----646511--------223578889985839---99999866997035----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .+|||-|.+.+.+| +.|.+|+..++.... T Consensus 69 -~~l~~~y~~~a~~~ilVydit~~~Sf-~~i~~w~~~i~~~~~------------------------------------- 109 (199) T cd04110 69 -RTITSTYYRGTHGVIVVYDVTNGESF-VNVKRWLQEIEQNCD------------------------------------- 109 (199) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCC------------------------------------- T ss_conf -67767650389879999877997799-999999999985125------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) -+|+++|..|+| |+..+-...|+.. .+|-++|+..|.||++...|...+.+ T Consensus 110 -----------------~~~~iLVGNK~D----l~~~r~v~~ee~~-------~~a~~~~~~f~EtSAktg~nV~e~F~ 160 (199) T cd04110 110 -----------------DVCKVLVGNKND----DPERKVVETEDAY-------KFAGQMGISLFETSAKENINVEEMFN 160 (199) T ss_pred -----------------CCCEEEEEECCC----CHHHCCCCHHHHH-------HHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf -----------------673699840336----3112265689999-------99996699599997158988889999 No 17 >cd04119 RJL RJL (RabJ-Like) subfamily. RJLs are found in many protists and as chimeras with C-terminal DNAJ domains in deuterostome metazoa. They are not found in plants, fungi, and protostome metazoa, suggesting a horizontal gene transfer between protists and deuterostome metazoa. RJLs lack any known membrane targeting signal and contain a degenerate phosphate/magnesium-binding 3 (PM3) motif, suggesting an impaired ability to hydrolyze GTP. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Probab=97.95 E-value=0.00017 Score=46.37 Aligned_columns=156 Identities=16% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+...+-.. ++..-- +.+| .++.-..++...++.+|=. .|...|..+. T Consensus 3 ivivGd~~vGKTsli~r~~~~~f~~----~y~~Ti--------g~~~---~~k~i~~~~~~~~l~iwDt-aG~e~~~~~~ 66 (168) T cd04119 3 VISMGNSGVGKSCIIKRYCEGRFVS----KYLPTI--------GIDY---GVKKVSVRNKEVRVNFFDL-SGHPEYLEVR 66 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEE---EEEEEEECCEEEEEEEEEC-CCCHHHHHHH T ss_conf 8998079854899998877180166----536503--------5555---5678888794899998606-8981257887 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--+ .++++-|.+++.++-. +.+|+.-++.++.....- T Consensus 67 ~~~~~~a~----~~ilvydit~~~Sf~~-i~~w~~~~~~~~~~~~~~--------------------------------- 108 (168) T cd04119 67 NEFYKDTQ----GVLLVYDVTDRQSFEA-LDSWLKEMKQEGGPHGNM--------------------------------- 108 (168) T ss_pred HHHHCCCC----EEEEEEECCCHHHHHH-HHHHHHHHHHHCCCCCCC--------------------------------- T ss_conf 88723999----3899985699778999-999999999860555666--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) -.+|+++|-+|+| |...+.-..++ .+.+|-++|+..|-||++...|...+ T Consensus 109 ---------------~~~~iilvGNK~D----l~~~r~V~~~~-------~~~~a~~~~~~~~E~SAk~~~nV~e~ 158 (168) T cd04119 109 ---------------ENIVVVVCANKID----LTKHRAVSEDE-------GRLWAESKGFKYFETSACTGEGVNEM 158 (168) T ss_pred ---------------CCCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHH T ss_conf ---------------8747999705323----32357679899-------99999964991999971589787899 No 18 >cd04124 RabL2 RabL2 subfamily. RabL2 (Rab-like2) subfamily. RabL2s are novel Rab proteins identified recently which display features that are distinct from other Rabs, and have been termed Rab-like. RabL2 contains RabL2a and RabL2b, two very similar Rab proteins that share 98% sequence identity in humans. RabL2b maps to the subtelomeric region of chromosome 22q13.3 and RabL2a maps to 2q13, a region that suggests it is also a subtelomeric gene. Both genes are believed to be expressed ubiquitously, suggesting that RabL2s are the first example of duplicated genes in human proximal subtelomeric regions that are both expressed actively. Like other Rab-like proteins, RabL2s lack a prenylation site at the C-terminus. The specific functions of RabL2a and RabL2b remain unknown. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-b Probab=97.93 E-value=0.00019 Score=46.12 Aligned_columns=146 Identities=21% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+...+-.. .+.. -.+-.++...- ..++....+.+|=. .|...| T Consensus 3 iiliGd~~VGKTsli~r~~~~~f~~----~~~~----------t~~~~~~~k~~-~~~~~~v~l~iwDt-~G~e~~---- 62 (161) T cd04124 3 IILLGDSAVGKSKLVERFLMDGYEP----QQLS----------TYALTLYKHNA-KFEGKTILVDFWDT-AGQERF---- 62 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEEE-EECCEEEEEEEEEC-CCCCHH---- T ss_conf 8998069944889887865386376----6235----------32567899999-99886999999745-784110---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+.-++++ .++|+-|.+.+.++ +.|.+|+.-++++-. T Consensus 63 -~~~~~~~~~~a~~~ilvfDit~~~Sf-~~l~~W~~~i~~~~~------------------------------------- 103 (161) T cd04124 63 -QTMHASYYHKAHACILVFDVTRKITY-KNLSKWYEELREYRP------------------------------------- 103 (161) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCC------------------------------------- T ss_conf -35667430247858999866996688-999999999998469------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) -+|+++|.+|+|. +.. +.+--+.++-++++..|+||+|...|...+ T Consensus 104 -----------------~~p~ilVGNK~Dl-----------~~~---~~~~~~~~a~~~~~~~fetSAk~g~nV~e~ 149 (161) T cd04124 104 -----------------EIPCIVVANKIDL-----------DPS---VTQKKFNFAEKHNLPLYYVSAADGTNVVKL 149 (161) T ss_pred -----------------CCEEEEEECCCCC-----------CHH---HHHHHHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf -----------------9379998237656-----------435---689999999965991999972689887899 No 19 >cd04160 Arfrp1 Arfrp1 subfamily. Arfrp1 (Arf-related protein 1), formerly known as ARP, is a membrane-associated Arf family member that lacks the N-terminal myristoylation motif. Arfrp1 is mainly associated with the trans-Golgi compartment and the trans-Golgi network, where it regulates the targeting of Arl1 and the GRIP domain-containing proteins, golgin-97 and golgin-245, onto Golgi membranes. It is also involved in the anterograde transport of the vesicular stomatitis virus G protein from the Golgi to the plasma membrane, and in the retrograde transport of TGN38 and Shiga toxin from endosomes to the trans-Golgi network. Arfrp1 also inhibits Arf/Sec7-dependent activation of phospholipase D. Deletion of Arfrp1 in mice causes embryonic lethality at the gastrulation stage and apoptosis of mesodermal cells, indicating its importance in development. Probab=97.92 E-value=0.00042 Score=43.99 Aligned_columns=162 Identities=22% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .||++|..+.|||+||..+.............+-.- .+|+.+..+.-.+ .++.+|=+ .|...|..+ T Consensus 1 ~IvliG~~~~GKTsll~rl~~~~~~~~~~~~~~~~~--------T~g~~~~~i~~~~-----~~l~iwD~-~Gqe~~~~~ 66 (167) T cd04160 1 SVLILGLDNAGKTTFLEQLKTLFSKYKGLPPSKITP--------TVGLNIGTIEVGN-----ARLKFWDL-GGQESLRSL 66 (167) T ss_pred CEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCEEE--------EEEEEEEEEEECC-----EEEEEEEC-CCCHHHHHH T ss_conf 978995189868999999852024456754440333--------5545898888878-----89999846-874046776 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) -+.... .--.+|+|+|-+++ +++..+..++.+.+..-... T Consensus 67 ~~~y~~----~a~~ii~VvD~sd~----~~~~~~~~~l~~~l~~~~~~-------------------------------- 106 (167) T cd04160 67 WDKYYA----ECHAIIYVIDSTDR----ERFEESKSALEKVLRNEALE-------------------------------- 106 (167) T ss_pred HHHHCC----CCCEEEEEEECCCC----CCHHHHHHHHHHHHHCCCCC-------------------------------- T ss_conf 764157----98679999744875----35688999999997221558-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ++|++|++.|+| .......|+.--+++-.-..+-+..-.+|.||++.-.+++..+. T Consensus 107 -----------------~~Pili~~NK~D------l~~~~~~eei~~~l~~~~~~~~~r~~~~~~~SA~tG~Gv~e~f~ 162 (167) T cd04160 107 -----------------GVPLLILANKQD------LPDALSVEEIKEVFQDKAEEIGRRDCLVLPVSALEGTGVREGIE 162 (167) T ss_pred -----------------CCEEEEEECCCC------CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------977999834879------53123788999999988998740891799985136888899999 No 20 >cd04123 Rab21 Rab21 subfamily. The localization and function of Rab21 are not clearly defined, with conflicting data reported. Rab21 has been reported to localize in the ER in human intestinal epithelial cells, with partial colocalization with alpha-glucosidase, a late endosomal/lysosomal marker. More recently, Rab21 was shown to colocalize with and affect the morphology of early endosomes. In Dictyostelium, GTP-bound Rab21, together with two novel LIM domain proteins, LimF and ChLim, has been shown to regulate phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site Probab=97.89 E-value=0.00029 Score=44.99 Aligned_columns=151 Identities=12% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....-.. ++..-- +.+|....+.-++.. ..+.+|=. .|...+..+. T Consensus 3 i~~iGd~~vGKTsli~r~~~~~f~~----~~~~ti--------~~~~~~k~i~~~~~~---~~l~iwDt-~G~~~~~~~~ 66 (162) T cd04123 3 VVLLGEGRVGKTSLVLRYVENKFNE----KHESTT--------QASFFQKTVNIGGKR---IDLAIWDT-AGQERYHALG 66 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCC--------CCCCEEEEEECCCCE---EEEEEEEC-CCCHHHHHHH T ss_conf 8998269965899999986281177----645411--------244135533159938---99997307-8750235665 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+. .-..++++-|.+.+.+|-. +++|+.-++++... T Consensus 67 ~~~~~----~a~~~ilvydit~~~Sf~~-i~~w~~~i~~~~~~------------------------------------- 104 (162) T cd04123 67 PIYYR----DADGAILVYDITDADSFQK-VKKWIKELKQMRGN------------------------------------- 104 (162) T ss_pred HHHHC----CCCEEEEEEECCCHHHHHH-HHHHHHHHHHHCCC------------------------------------- T ss_conf 76614----8986899942798778999-99999989973189------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|.+|+| |++++.-..++ .+.+|-++|+..|-||++...|...+ T Consensus 105 ----------------~~piilVGNK~D----l~~~r~V~~~~-------~~~~a~~~~~~~~E~Sak~~~nv~e~ 153 (162) T cd04123 105 ----------------NISLVIVGNKID----LERQRVVSKSE-------AEEYAKSVGAKHFETSAKTGKGIEEL 153 (162) T ss_pred ----------------CCEEEEEEEHHH----HHHHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------965999840023----12102547789-------99999964993899971589787899 No 21 >cd04159 Arl10_like Arl10-like subfamily. Arl9/Arl10 was identified from a human cancer-derived EST dataset. No functional information about the subfamily is available at the current time, but crystal structures of human Arl10b and Arl10c have been solved. Probab=97.88 E-value=0.00012 Score=47.33 Aligned_columns=153 Identities=20% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) +|+++|..+.|||+|+..+....... +... -+||.|..|...+ .++.+|=+ .|...|.++ T Consensus 1 ~IvivG~~~vGKTsl~~~~~~~~f~~----~~~~----------Tig~~~~~i~~~~-----~~l~iwDt-aGqe~~~~~ 60 (159) T cd04159 1 EITLVGLQNSGKTTLVNVIAGGQFSE----DTIP----------TVGFNMRKVTKGN-----VTLKVWDL-GGQPRFRSM 60 (159) T ss_pred CEEEEECCCCCHHHHHHHHHCCCCCC----CEEE----------EEEEEEEEEEECC-----EEEEEEEC-CCCHHHHHH T ss_conf 97899428986899999875494165----3230----------0002799988477-----89999855-873135788 Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 0110581012003-343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) . +.-++++ .+|+|.|-|++ +++.....++++.+.....+ T Consensus 61 ~-----~~y~~~a~~ii~V~D~td~----~s~~~~~~~l~~ll~~~~~~------------------------------- 100 (159) T cd04159 61 W-----ERYCRGVNAIVYVVDAADR----TALEAAKNELHDLLEKPSLE------------------------------- 100 (159) T ss_pred H-----HHHHHCCCCEEEEEECCCH----HHHHHHHHHHHHHHHCCCCC------------------------------- T ss_conf 9-----8763104851799854886----67899999999875103779------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 64532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ++|+++|+.|+|.-+.+..+.--.+..++.+++. .-..|-||++...+++.++. T Consensus 101 ------------------~ipili~gNK~Dl~~~~~~~e~~~~~~~~~~~~~--------~~~~~~~SAktg~gI~e~f~ 154 (159) T cd04159 101 ------------------GIPLLVLGNKNDLPGALSVDELIEQMNLKSITDR--------EVSCYSISCKEKTNIDIVLD 154 (159) T ss_pred ------------------CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC--------CCEEEEEECCCCCCHHHHHH T ss_conf ------------------9579998124684212588899999989998518--------94589986147988899999 No 22 >cd04125 RabA_like RabA-like subfamily. RabA was first identified in D. discoideum, where its expression levels were compared to other Rabs in growing and developing cells. The RabA mRNA levels were below the level of detection by Northern blot analysis, suggesting a very low level of expression. The function of RabA remains unknown. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=97.88 E-value=0.00031 Score=44.82 Aligned_columns=150 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....... .+..-- |.+|..-.|.=.+.. ..+.+|=.+..+-+ T Consensus 3 IvviGd~~VGKTsli~r~~~~~f~~----~~~~Ti--------g~d~~~k~i~~~~~~---v~l~iwDtaGqe~~----- 62 (188) T cd04125 3 VVIIGDYGVGKSSLLKRFTEDEFSE----STKSTI--------GVDFKIKTVYIENKI---IKLQIWDTNGQERF----- 62 (188) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEEECCEE---EEEEEEECCCCCHH----- T ss_conf 8998269954899999876280177----646730--------212578899986849---99998756998202----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .+||+-|.+.+.+| +.+++|+.-++++... T Consensus 63 -~~l~~~~~~~a~~~ilvyDit~~~Sf-~~i~~w~~~i~~~~~~------------------------------------ 104 (188) T cd04125 63 -RSLNNSYYRGAHGYLLVYDVTDQESF-ENLKFWINEINRYARE------------------------------------ 104 (188) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -56768763089859999866997899-9999999999861699------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|++|+| |+.++.-..++ .+.||-++|+..|-||++...|...+ T Consensus 105 -----------------~~~~ilvgNK~D----L~~~r~V~~~~-------~~~~a~~~~~~~fEtSAktg~nV~e~ 153 (188) T cd04125 105 -----------------NVIKVIVANKSD----LVNNKVVDSNI-------AKSFCDSLNIPFFETSAKQSINVEEA 153 (188) T ss_pred -----------------CCEEEEEEECCC----CHHHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf -----------------968999851352----30123369999-------99999856992999962589888899 No 23 >cd04128 Spg1 Spg1p. Spg1p (septum-promoting GTPase) was first identified in the fission yeast S. pombe, where it regulates septum formation in the septation initiation network (SIN) through the cdc7 protein kinase. Spg1p is an essential gene that localizes to the spindle pole bodies. When GTP-bound, it binds cdc7 and causes it to translocate to spindle poles. Sid4p (septation initiation defective) is required for localization of Spg1p to the spindle pole body, and the ability of Spg1p to promote septum formation from any point in the cell cycle depends on Sid4p. Spg1p is negatively regulated by Byr4 and cdc16, which form a two-component GTPase activating protein (GAP) for Spg1p. The existence of a SIN-related pathway in plants has been proposed. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are Probab=97.88 E-value=0.0005 Score=43.50 Aligned_columns=155 Identities=19% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+-......-.. .+.--- |+.|.-..+.=.+.. ..+.+|=. .|.-.|..+. T Consensus 3 ivliGd~~VGKTsLi~r~~~~~F~~----~y~~Ti--------G~~~~~k~i~v~~~~---v~l~iwDt-aGqE~f~~~~ 66 (182) T cd04128 3 IGLLGDAQIGKTSLMVKYVEGEFDE----DYIQTL--------GVNFMEKTISIRGTE---ITFSIWDL-GGQREFINML 66 (182) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCEE--------EEEEEEEEEEECCEE---EEEEEEEC-CCCCCCHHHH T ss_conf 8998169843888877764371277----635503--------446789899988968---99887316-8883101277 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +....--. .++|+-|.+.+-+| +.+++|+..++.+ ... T Consensus 67 ~~y~~~a~----~~ilVfDit~~~Sf-~~i~~W~~~i~~~----~~~--------------------------------- 104 (182) T cd04128 67 PLVCNDAV----AILFMFDLTRKSTL-NSIKEWYRQARGF----NKT--------------------------------- 104 (182) T ss_pred HHHCCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHH----CCC--------------------------------- T ss_conf 86403777----68999865997899-9999999999862----799--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|| +|-+|+|.+ .+...+.-+.+....+.+|-++|+.+|.||.|...|...+ T Consensus 105 ----------------~~~I-LVGNK~DL~------~~~~~~~~~~~~~~~~~~a~~~~~~~~etSAktg~nV~e~ 157 (182) T cd04128 105 ----------------AIPI-LVGTKYDLF------ADLPPEEQEEITKQARKYAKAMKAPLIFCSTSHSINVQKI 157 (182) T ss_pred ----------------CCEE-EEECCCCCC------CCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------6089-983274310------0144245677889999999972995999972479887899 No 24 >cd04136 Rap_like Rap-like subfamily. The Rap subfamily consists of the Rap1, Rap2, and RSR1. Rap subfamily proteins perform different cellular functions, depending on the isoform and its subcellular localization. For example, in rat salivary gland, neutrophils, and platelets, Rap1 localizes to secretory granules and is believed to regulate exocytosis or the formation of secretory granules. Rap1 has also been shown to localize in the Golgi of rat fibroblasts, zymogen granules, plasma membrane, and microsomal membrane of the pancreatic acini, as well as in the endocytic compartment of skeletal muscle cells and fibroblasts. Rap1 localizes in the nucleus of human oropharyngeal squamous cell carcinomas (SCCs) and cell lines. Rap1 plays a role in phagocytosis by controlling the binding of adhesion receptors (typically integrins) to their ligands. In yeast, Rap1 has been implicated in multiple functions, including activation and silencing of transcription and maintenance of telomeres. Probab=97.87 E-value=0.00018 Score=46.22 Aligned_columns=151 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+-||++|+..+...+ ....-.|-+++.+--.. ..++....+.+|=. .|...|..+. T Consensus 4 iilvGd~~VGKTsli~r~~~~~--------f~~~~~~ti~~~~~k~i--------~v~~~~~~l~iwDt-aG~e~~~~l~ 66 (163) T cd04136 4 VVVLGSGGVGKSALTVQFVQGI--------FVEKYDPTIEDSYRKQI--------EVDGQQCMLEILDT-AGTEQFTAMR 66 (163) T ss_pred EEEEECCCCCHHHHHHHHHCCE--------ECCCCCCCCCCCEEEEE--------EECCEEEEEEEEEC-CCCHHHHHHH T ss_conf 8997079843899999886280--------06765651000126889--------88896899998847-9980356888 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--.. ++|+-|.+.+.+| +.+.+|...+......- T Consensus 67 ~~~~~~a~~----~ilvfdvt~~~Sf-~~i~~~~~~i~~~~~~~------------------------------------ 105 (163) T cd04136 67 DLYIKNGQG----FVLVYSITSQSSF-NDLQDLREQILRVKDTE------------------------------------ 105 (163) T ss_pred HHHHCCCCE----EEEEEECCCHHHH-HHHHHHHHHHHHHCCCC------------------------------------ T ss_conf 875116882----8999756997888-99999999999740899------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|.+|+| |+.++-...++ ...++-++|+..|.||++...|...+ T Consensus 106 ----------------~ip~ilVGNK~D----L~~~r~v~~~~-------~~~~a~~~~~~~~E~Sak~~~nv~e~ 154 (163) T cd04136 106 ----------------NVPMVLVGNKCD----LEDERVVSREE-------GQALARQWGCPFYETSAKSKINVDEV 154 (163) T ss_pred ----------------CCEEEEECCCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------938999724467----64656379899-------99999966995999971479787899 No 25 >cd04156 ARLTS1 ARLTS1 subfamily. ARLTS1 (Arf-like tumor suppressor gene 1), also known as Arl11, is a member of the Arf family of small GTPases that is believed to play a major role in apoptotic signaling. ARLTS1 is widely expressed and functions as a tumor suppressor gene in several human cancers. ARLTS1 is a low-penetrance suppressor that accounts for a small percentage of familial melanoma or familial chronic lymphocytic leukemia (CLL). ARLTS1 inactivation seems to occur most frequently through biallelic down-regulation by hypermethylation of the promoter. In breast cancer, ARLTS1 alterations were typically a combination of a hypomorphic polymorphism plus loss of heterozygosity. In a case of thyroid adenoma, ARLTS1 alterations were polymorphism plus promoter hypermethylation. The nonsense polymorphism Trp149Stop occurs with significantly greater frequency in familial cancer cases than in sporadic cancer cases, and the Cys148Arg polymorphism is associated with an increase in h Probab=97.85 E-value=0.00027 Score=45.14 Aligned_columns=154 Identities=19% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) ||++|..++|||+||-.+...+-....+.. |...-.+++.. ..++.+|=+ .|.-.+..+- T Consensus 2 IlilG~~~sGKTsll~rl~~~~~~~~~pTi-------------g~~~~~~~~~~------~v~l~iwD~-~G~e~~r~~~ 61 (160) T cd04156 2 VLLLGLDSAGKSTLLYKLKHAELVTTIPTV-------------GFNVEMLQLEK------HLSLTVWDV-GGQEKMRTVW 61 (160) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCEEEEE-------------CEEEEEEEECC------EEEEEEEEC-CCCHHHHHHH T ss_conf 789950898689988877458623022000-------------10488998768------379998745-8740346666 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +....--.. +|+|+|-|++ +++..|..++.+.+..-... T Consensus 62 ~~y~~~a~~----iI~V~D~sd~----~~~~~~~~~l~~~l~~~~~~--------------------------------- 100 (160) T cd04156 62 KCYLENTDG----LVYVVDSSDE----ARLDESQKELKHILKNEHIK--------------------------------- 100 (160) T ss_pred HHHCCCCCE----EEEEEECCCH----HHHHHHHHHHHHHHHHHCCC--------------------------------- T ss_conf 764057637----9999725783----46899999999885200127--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHH-HHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999-99999871841255212332103456553 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQF-MRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~-lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) ++|+++|+.|+|.-..+..+. ....+ +.++|-.++.-++.||++--.++..+.+. T Consensus 101 ----------------~~p~liv~NK~Dl~~~~~~~e--------i~~~l~l~~~~~~~~~~i~~~SA~tG~gi~e~F~~ 156 (160) T cd04156 101 ----------------GVPVVLLANKQDLPGALTAEE--------ITRRFKLKKYCSDRDWYVQPCSAVTGEGLAEAFRK 156 (160) T ss_pred ----------------CCEEEEEEECCCCCCCCCHHH--------HHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH T ss_conf ----------------975999960558854578899--------99899899998608938999731468577899999 No 26 >smart00175 RAB Rab subfamily of small GTPases; Rab GTPases are implicated in vesicle trafficking. Probab=97.85 E-value=0.00023 Score=45.57 Aligned_columns=161 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+-..+-.. +..- -+|..|.... -..++....+.+|=.+..+.+ T Consensus 3 iviiG~~~vGKTsii~~~~~~~f~~----~~~~----------Ti~~~~~~k~-v~~~~~~~~l~i~Dt~g~e~~----- 62 (164) T smart00175 3 IILIGDSGVGKSSLLSRFTDGKFSE----DSKS----------TIGVDFKTKT-IEVDGKRVKLQIWDTAGQERF----- 62 (164) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEEEEE-EEECCEEEEEEEEECCCCHHH----- T ss_conf 8998269964899999986281066----5565----------0223677899-999896999998646987146----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .++|+-|.+.+.+| +.+.+|...++.+... T Consensus 63 -~~~~~~~~~~~d~~iivfdi~~~~Sf-~~i~~w~~~i~~~~~~------------------------------------ 104 (164) T smart00175 63 -RSITSSYYRGAVGALLVYDITNRDSF-ENLENWLKELREYADP------------------------------------ 104 (164) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -77778750489769999327987799-9999999999972699------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|+++|.+|+|. +.++.-..++ .+.+|-++|...|-||.+...+...+... T Consensus 105 -----------------~~piilvgNK~Dl----~~~~~i~~~e-------~~~~a~~~~~~y~E~Sak~~~~i~e~F~~ 156 (164) T smart00175 105 -----------------NVVIMLVGNKSDL----EEQRQVSTEE-------AQKFAEEHGLLFIETSAKTNTNVEEAFEE 156 (164) T ss_pred -----------------CCEEEEEEECCCC----CCCCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHHH T ss_conf -----------------9589998511022----0002589899-------99999964982999970479887899999 Q ss_pred HCCCCCCCCC Q ss_conf 2253224667 Q Fun_An_XP_0013 288 SLGIHSLLKR 297 (523) Q Consensus 288 ~lgih~ll~~ 297 (523) . +..++++ T Consensus 157 l--~~~i~~~ 164 (164) T smart00175 157 L--AKEILKR 164 (164) T ss_pred H--HHHHHHC T ss_conf 9--9999719 No 27 >cd04116 Rab9 Rab9 subfamily. Rab9 is found in late endosomes, together with mannose 6-phosphate receptors (MPRs) and the tail-interacting protein of 47 kD (TIP47). Rab9 is a key mediator of vesicular transport from late endosomes to the trans-Golgi network (TGN) by redirecting the MPRs. Rab9 has been identified as a key component for the replication of several viruses, including HIV1, Ebola, Marburg, and measles, making it a potential target for inhibiting a variety of viruses. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CX Probab=97.85 E-value=0.00033 Score=44.58 Aligned_columns=153 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+-.. +...-- |.+|....+.-.++. ..+.+|=. .|...| T Consensus 8 ivliGd~~vGKTsLi~rf~~~~f~~----~~~~ti--------g~~~~~k~i~~~~~~---~~l~i~Dt-ag~e~~---- 67 (170) T cd04116 8 VILLGDGGVGKSSLMNRYVTNKFDT----QLFHTI--------GVEFLNKDLEVDGHF---VTLQIWDT-AGQERF---- 67 (170) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCC----CCCCCE--------EECCEEEECCCCCCE---EEEEEECC-CCCCHH---- T ss_conf 9998079954899998875381177----734732--------311022000047964---89998707-898101---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .++.+.-++++ .++|+-|-+++.+|-. +..|+.-+....+.-..+ T Consensus 68 -~~l~~~~~~~~~~~iivydit~~~Sf~~-i~~w~~e~~~~~~~~~~~-------------------------------- 113 (170) T cd04116 68 -RSLRTPFYRGSDCCLLTFAVDDSQSFQN-LSNWKKEFIYYADVKEPE-------------------------------- 113 (170) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHHHH-HHHHHHHHHHHCCCCCCC-------------------------------- T ss_conf -2311576318984899985499768999-999999999860357789-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCE-EEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841-255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGAS-LIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAs-LiYTS~~~~~nl~~L 284 (523) .+|+++|++|+|. ++-....+=.+.+|-++|.. .|.||++...|.+.+ T Consensus 114 -----------------~ipiilVGNK~DL------------~~r~V~~~e~~~~~~~~~~~~~~E~SAk~g~nv~~~ 162 (170) T cd04116 114 -----------------SFPFVVLGNKNDI------------PERQVSTEEAQAWCRENGDYPYFETSAKDATNVAAA 162 (170) T ss_pred -----------------CCEEEEEECCCCC------------HHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH T ss_conf -----------------7079998354220------------111011789999999707971789860489887899 No 28 >cd04137 RheB Rheb (Ras Homolog Enriched in Brain) subfamily. Rheb was initially identified in rat brain, where its expression is elevated by seizures or by long-term potentiation. It is expressed ubiquitously, with elevated levels in muscle and brain. Rheb functions as an important mediator between the tuberous sclerosis complex proteins, TSC1 and TSC2, and the mammalian target of rapamycin (TOR) kinase to stimulate cell growth. TOR kinase regulates cell growth by controlling nutrient availability, growth factors, and the energy status of the cell. TSC1 and TSC2 form a dimeric complex that has tumor suppressor activity, and TSC2 is a GTPase activating protein (GAP) for Rheb. The TSC1/TSC2 complex inhibits the activation of TOR kinase through Rheb. Rheb has also been shown to induce the formation of large cytoplasmic vacuoles in a process that is dependent on the GTPase cycle of Rheb, but independent of the TOR kinase, suggesting Rheb plays a role in endocytic trafficking that le Probab=97.79 E-value=0.00038 Score=44.20 Aligned_columns=154 Identities=14% Q ss_pred EEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHH Q ss_conf 04788647798732123233111124556631225656744443342022331000677455110167871788711232 Q Fun_An_XP_0013 47 KNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAP 126 (523) Q Consensus 47 KnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~ 126 (523) |-|+++|..+-|||+|+..+.... ....-.|-|++.|.-.. ..++..-.+.+|=. .|...|.. T Consensus 2 ~KIvliGd~~VGKTsli~rf~~~~--------f~~~y~~Ti~~~~~k~i--------~v~~~~~~l~iwDt-aGqe~~~~ 64 (180) T cd04137 2 RKIAVLGSRSVGKSSLTVQFVEGH--------FVESYYPTIENTFSKII--------RYKGQDYHLEIVDT-AGQDEYSI 64 (180) T ss_pred EEEEEEECCCCCHHHHHHHHHCCC--------CCCCCCCCEECCCCCCE--------EECCEEEEEEECCC-CCCCCCHH T ss_conf 078997079843899999986180--------07764661000312003--------56682689987478-87320002 Q ss_pred HHH-HCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC Q ss_conf 001-1058101200334333000031368999999999999998506958889999999998622688767777767777 Q Fun_An_XP_0013 127 LLK-PLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFT 205 (523) Q Consensus 127 LLk-~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~ 205 (523) +-. |.-.+. -++|+-|.+.+-+| +.++.|..-+.+...+- T Consensus 65 l~~~~~~~a~-----~~ilvfdit~~~Sf-~~i~~~~~~i~~~~~~~--------------------------------- 105 (180) T cd04137 65 LPQKYSIGIH-----GYILVYSVTSRKSF-EVVKVIYDKILDMLGKE--------------------------------- 105 (180) T ss_pred HHHHHCCCCC-----EEEEEEECCCHHHH-HHHHHHHHHHHHHHCCC--------------------------------- T ss_conf 3366504887-----38998544897678-99999999999861899--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHH Q ss_conf 66453213688875326789507999618755678886358855689999999999998718412552123321034565 Q Fun_An_XP_0013 206 SSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLI 285 (523) Q Consensus 206 ~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Ll 285 (523) .+|+++|.+||| |..++...+++ ...+|-++|+..|.||++...|...+. T Consensus 106 -------------------~ipiiLvGNK~D----l~~~r~V~~~e-------~~~~a~~~~~~~~E~SAk~~~nV~e~F 155 (180) T cd04137 106 -------------------SVPIVLVGNKSD----LHTQRQVSTEE-------GKELAESWGAAFLESSARENENVEEAF 155 (180) T ss_pred -------------------CCEEEEEEECCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHH T ss_conf -------------------848999420168----51236579899-------999999659978998615798888999 Q ss_pred H Q ss_conf 5 Q Fun_An_XP_0013 286 H 286 (523) Q Consensus 286 h 286 (523) + T Consensus 156 ~ 156 (180) T cd04137 156 E 156 (180) T ss_pred H T ss_conf 9 No 29 >cd04139 RalA_RalB RalA/RalB subfamily. The Ral (Ras-like) subfamily consists of the highly homologous RalA and RalB. Ral proteins are believed to play a crucial role in tumorigenesis, metastasis, endocytosis, and actin cytoskeleton dynamics. Despite their high sequence similarity (80% sequence identity), nonoverlapping and opposing functions have been assigned to RalA and RalBs in tumor migration. In human bladder and prostate cancer cells, RalB promotes migration while RalA inhibits it. A Ral-specific set of GEFs has been identified that are activated by Ras binding. This RalGEF activity is enhanced by Ras binding to another of its target proteins, phosphatidylinositol 3-kinase (PI3K). Ral effectors include RLIP76/RalBP1, a Rac/cdc42 GAP, and the exocyst (Sec6/8) complex, a heterooctomeric protein complex that is involved in tethering vesicles to specific sites on the plasma membrane prior to exocytosis. In rat kidney cells, RalB is required for functional assembly of the exo Probab=97.78 E-value=0.00025 Score=45.31 Aligned_columns=161 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+...+-.. ++.- -+|-.|.-...-|... ..+.+|=.+....+ T Consensus 3 ivliGd~~VGKTsli~r~~~~~f~~----~~~~----------Ti~~~~~~~i~~~~~~--v~l~iwDt~Gqe~~----- 61 (164) T cd04139 3 VIVVGAGGVGKSALTLQFMYDEFVE----DYEP----------TKADSYRKKVVLDGED--VQLNILDTAGQEDY----- 61 (164) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CCCCEEEEEEEECCCE--EEEEEEECCCCHHH----- T ss_conf 8998179854899999987182076----5443----------2232146899885938--99998427887135----- Q ss_pred HHCCCHHHHCC-EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200-33433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPE-TLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~-TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..+++ ..++|+-|.+.+.+| +.+.+|..-+..+...- T Consensus 62 -~~l~~~~~~~a~~~ilvydit~~~Sf-~~i~~~~~~~~~~~~~~----------------------------------- 104 (164) T cd04139 62 -AAIRDNYHRSGEGFLLVFSITDMESF-TATAEFREQILRVKDDD----------------------------------- 104 (164) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHHCCC----------------------------------- T ss_conf -78888752589879999752885578-89999999999861799----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|+++|-+|+|. +++--.-.+..+.+|-++|+..|-||++...|...+... T Consensus 105 -----------------~ip~ilvGNK~Dl-----------~~~r~v~~~e~~~~a~~~~~~~~E~SAk~g~ni~e~F~~ 156 (164) T cd04139 105 -----------------NVPLLLVGNKCDL-----------EDKRQVSSEEAANLARQWGVPYVETSAKTRQNVEKAFYD 156 (164) T ss_pred -----------------CCEEEEECCCHHH-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------7279997240132-----------231167489999999965995999971589887899999 Q ss_pred HCCCCCCCCC Q ss_conf 2253224667 Q Fun_An_XP_0013 288 SLGIHSLLKR 297 (523) Q Consensus 288 ~lgih~ll~~ 297 (523) . +..+++| T Consensus 157 l--~~~i~~r 164 (164) T cd04139 157 L--VREIRQR 164 (164) T ss_pred H--HHHHHCC T ss_conf 9--9999609 No 30 >cd04151 Arl1 Arl1 subfamily. Arl1 (Arf-like 1) localizes to the Golgi complex, where it is believed to recruit effector proteins to the trans-Golgi network. Like most members of the Arf family, Arl1 is myristoylated at its N-terminal helix and mutation of the myristoylation site disrupts Golgi targeting. In humans, the Golgi-localized proteins golgin-97 and golgin-245 have been identified as Arl1 effectors. Golgins are large coiled-coil proteins found in the Golgi, and these golgins contain a C-terminal GRIP domain, which is the site of Arl1 binding. Additional Arl1 effectors include the GARP (Golgi-associated retrograde protein)/VFT (Vps53) vesicle-tethering complex and Arfaptin 2. Arl1 is not required for exocytosis, but appears necessary for trafficking from the endosomes to the Golgi. In Drosophila zygotes, mutation of Arl1 is lethal, and in the host-bloodstream form of Trypanosoma brucei, Arl1 is essential for viability. Probab=97.78 E-value=0.00019 Score=46.11 Aligned_columns=152 Identities=16% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) ||+||..++|||+|+..+.........+.. |..+..++..+ ..+.+|-+ .|.-.+..+- T Consensus 2 ililG~~~~GKTsii~r~~~~~~~~~~pT~-------------g~~~~~i~~~~-------~~~~iwD~-~Gqe~~r~~~ 60 (158) T cd04151 2 ILILGLDNAGKTTILYRLQLGEVVTTIPTI-------------GFNVETVTYKN-------LKFQVWDL-GGQTSIRPYW 60 (158) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCC-------------EEEEEEEEECC-------EEEEEEEC-CCCCCCCHHH T ss_conf 788950898688877766438621200320-------------01588986178-------18999754-8874342135 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +....--.. +|+|+|-++. +++..+...+.+.+..-... T Consensus 61 ~~y~~~a~~----iI~V~D~sd~----~~~~~~~~~l~~~l~~~~~~--------------------------------- 99 (158) T cd04151 61 RCYYSNTDA----IIYVVDSTDR----DRLGTAKEELHAMLEEEELK--------------------------------- 99 (158) T ss_pred HHHCCCCCE----EEEEEECCCH----HHHHHHHHHHHHHHHCCCCC--------------------------------- T ss_conf 644037787----9999845883----46899999999997200447--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ++|+++++.|+|.-..+..+.=.....++.+. .+...+|.||++.-..+...++ T Consensus 100 ----------------~~pilIl~NK~Dl~~~~~~~~i~~~~~l~~~~--------~~~~~~~~~SA~tg~Gi~e~f~ 153 (158) T cd04151 100 ----------------GAVLLVFANKQDMPGALSEAEISEKLGLSELK--------DRTWSIFKTSAIKGEGLDEGMD 153 (158) T ss_pred ----------------CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHH--------CCCEEEEEEECCCCCCHHHHHH T ss_conf ----------------98899995067862137988999998678871--------3882899874136988899999 No 31 >cd04115 Rab33B_Rab33A Rab33B/Rab33A subfamily. Rab33B is ubiquitously expressed in mouse tissues and cells, where it is localized to the medial Golgi cisternae. It colocalizes with alpha-mannose II. Together with the other cisternal Rabs, Rab6A and Rab6A', it is believed to regulate the Golgi response to stress and is likely a molecular target in stress-activated signaling pathways. Rab33A (previously known as S10) is expressed primarily in the brain and immune system cells. In humans, it is located on the X chromosome at Xq26 and its expression is down-regulated in tuberculosis patients. Experimental evidence suggests that Rab33A is a novel CD8+ T cell factor that likely plays a role in tuberculosis disease processes. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine Probab=97.78 E-value=0.00061 Score=42.96 Aligned_columns=152 Identities=13% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHH-HHH Q ss_conf 7886477987321232331111245566312256567444433420223310006774551101678717887112-320 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSF-APL 127 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~-~~L 127 (523) |+++|+.+.||++|+..+...+ ....-.... |++|..-.+.=++.. .++.+|=- .|.-.| ..+ T Consensus 5 ivliGd~~VGKTsli~r~~~~~-------F~~~~~~Ti-----g~d~~~k~i~~~~~~---v~l~iwDt-aGqe~f~~~l 68 (170) T cd04115 5 IIVIGDSNVGKTCLTYRFCAGR-------FPERTEATI-----GVDFRERTVEIDGER---IKVQLWDT-AGQERFRKSM 68 (170) T ss_pred EEEEECCCCCHHHHHHHHHCCC-------CCCCCCCEE-----EEEEEEEEEEECCEE---EEEEEECC-CCCHHHHHHH T ss_conf 9998079965899999986285-------575445312-----203578999988958---99998227-8733567777 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+.--+ .++|+-|.+.+.+|-. |.+|+.-++.+...- T Consensus 69 ~~~y~~~a~----~~ilvydit~~~SF~~-i~~w~~~i~~~~~~~----------------------------------- 108 (170) T cd04115 69 VQHYYRNVH----AVVFVYDVTNMASFHS-LPSWIEECEQHSLPN----------------------------------- 108 (170) T ss_pred HHHHCCCCC----EEEEEEECCCHHHHHH-HHHHHHHHHHHCCCC----------------------------------- T ss_conf 654304898----4899987699778899-999999999725998----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCC---CCCCHHHH Q ss_conf 453213688875326789507999618755678886358855689999999999998718412552123---32103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPF---LANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~---~~~nl~~L 284 (523) -+|+++|++||| |++.+....++ .+.+|-++|+..|-||+| +..|...+ T Consensus 109 -----------------~~p~iLVGNK~D----L~~~r~Vs~~e-------~~~~A~~~~~~~fE~SAK~~~~~~nV~~~ 160 (170) T cd04115 109 -----------------EVPRILVGNKCD----LREQIQVPTDL-------AQRFADAHSMPLFETSAKDPSENDHVEAI 160 (170) T ss_pred -----------------CCEEEEEECCCC----CHHHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCCCCHHHH T ss_conf -----------------617999802135----01213679899-------99999966995999862678888687899 No 32 >cd04117 Rab15 Rab15 subfamily. Rab15 colocalizes with the transferrin receptor in early endosome compartments, but not with late endosomal markers. It codistributes with Rab4 and Rab5 on early/sorting endosomes, and with Rab11 on pericentriolar recycling endosomes. It is believed to function as an inhibitory GTPase that regulates distinct steps in early endocytic trafficking. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to Probab=97.77 E-value=0.00042 Score=43.96 Aligned_columns=154 Identities=19% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+......+-.. .+..-- |..| ....-..++....+.+|=.+..+-+ T Consensus 3 IiliGd~~VGKTsli~rf~~~~F~~----~~~~Ti--------g~~~---~~k~i~~~~~~i~l~iwDtaG~e~~----- 62 (161) T cd04117 3 LLLIGDSGVGKTCLLCRFTDNEFHS----SHISTI--------GVDF---KMKTIEVDGIKVRIQIWDTAGQERY----- 62 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCC--------CCEE---EEEEEEECCEEEEEEEEECCCCHHH----- T ss_conf 8998269844899999875482175----434422--------1114---6789989896999998746987235----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+.-++++ .++|+-|.+++-++ +.+.+|+.-++++-.. T Consensus 63 -~~l~~~~~~~a~~~ilvydit~~~Sf-~~i~~w~~~i~~~~~~------------------------------------ 104 (161) T cd04117 63 -QTITKQYYRRAQGIFLVYDISSERSY-QHIMKWVSDVDEYAPE------------------------------------ 104 (161) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -66768644699889999865997899-9999999999972579------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|+++|.+|+| |++.+.-.+++ .+.++-++|+..|.||++...|...+-+. T Consensus 105 -----------------~~~~ilVgnK~D----l~~~r~v~~~e-------~~~~a~~~~~~~~E~SAk~~~nV~e~F~~ 156 (161) T cd04117 105 -----------------GVQKILIGNKAD----EEQKRQVGDEQ-------GNKLAKEYGMDFFETSACTNSNIKESFTR 156 (161) T ss_pred -----------------CCEEEEEECCCC----HHHHHHHHHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------946999811578----02311146899-------99999965996999971589887899999 Q ss_pred H Q ss_conf 2 Q Fun_An_XP_0013 288 S 288 (523) Q Consensus 288 ~ 288 (523) . T Consensus 157 l 157 (161) T cd04117 157 L 157 (161) T ss_pred H T ss_conf 9 No 33 >cd04146 RERG_RasL11_like RERG/RasL11-like subfamily. RERG (Ras-related and Estrogen- Regulated Growth inhibitor) and Ras-like 11 are members of a novel subfamily of Ras that were identified based on their behavior in breast and prostate tumors, respectively. RERG expression was decreased or lost in a significant fraction of primary human breast tumors that lack estrogen receptor and are correlated with poor clinical prognosis. Elevated RERG expression correlated with favorable patient outcome in a breast tumor subtype that is positive for estrogen receptor expression. In contrast to most Ras proteins, RERG overexpression inhibited the growth of breast tumor cells in vitro and in vivo. RasL11 was found to be ubiquitously expressed in human tissue, but down-regulated in prostate tumors. Both RERG and RasL11 lack the C-terminal CaaX prenylation motif, where a = an aliphatic amino acid and X = any amino acid, and are localized primarily in the cytoplasm. Both are believed to have tu Probab=97.76 E-value=0.0004 Score=44.11 Aligned_columns=153 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+...-..+-.. ++.. -+|=.| ......++...++.+|=.+..+.+....+ T Consensus 2 Iv~iGd~~vGKTsLi~r~~~~~F~~----~y~~----------ti~~~~--~k~~~v~~~~v~l~i~DtaG~e~~~~~~~ 65 (165) T cd04146 2 IAVLGASGVGKSALVVRFLTKRFIG----EYDP----------NLESLY--SRQVTIDGEQVSLEILDTAGQQQADTEQL 65 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CHHHHH--EEEEEECCCEEEEEEECCCCCHHHHHHCC T ss_conf 7888179832899999986174477----5463----------012111--00002259448999722777201100000 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) ...+.--. .+|++-|.+.+-+| +.++.|...++++-... T Consensus 66 ~~~~~~ad----~~ilvydit~~~SF-~~i~~~~~~i~~~~~~~------------------------------------ 104 (165) T cd04146 66 ERSIRWAD----GFVLVYSITDRSSF-DEISQLKQLIREIKKRD------------------------------------ 104 (165) T ss_pred CCCCCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHHCCCC------------------------------------ T ss_conf 13546888----79999766985368-99999999999751479------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCC-CCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332-103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLA-NSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~-~nl~~L 284 (523) -.+|+++|.+||| |+.++....|+ .+.+|-++|+..|.||.+.. +|...+ T Consensus 105 ---------------~~~piilVGNK~D----L~~~r~V~~ee-------~~~~a~~~~~~~~E~SAk~~~~~V~e~ 155 (165) T cd04146 105 ---------------REIPVILVGNKAD----LLHYRQVSTEE-------GEKLASELGCLFFEVSAAEDYDGVHSV 155 (165) T ss_pred ---------------CCCEEEEECCCCC----CHHCCCCCHHH-------HHHHHHHCCCCEEEEEECCCCCHHHHH T ss_conf ---------------9827999723336----00105469899-------999999659958998604588027999 No 34 >cd01862 Rab7 Rab7 subfamily. Rab7 is a small Rab GTPase that regulates vesicular traffic from early to late endosomal stages of the endocytic pathway. The yeast Ypt7 and mammalian Rab7 are both involved in transport to the vacuole/lysosome, whereas Ypt7 is also required for homotypic vacuole fusion. Mammalian Rab7 is an essential participant in the autophagic pathway for sequestration and targeting of cytoplasmic components to the lytic compartment. Mammalian Rab7 is also proposed to function as a tumor suppressor. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C- Probab=97.74 E-value=0.00067 Score=42.71 Aligned_columns=154 Identities=19% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....-.. ++.. -+|..|..-.- ..++....+.+|=. .|...| T Consensus 3 ivliGd~~vGKTsli~r~~~~~f~~----~y~~----------Tig~~~~~k~i-~~~~~~~~l~i~Dt-~G~e~~---- 62 (172) T cd01862 3 VIILGDSGVGKTSLMNQYVNKKFSN----QYKA----------TIGADFLTKEV-TVDDKLVTLQIWDT-AGQERF---- 62 (172) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEEE-EECCEEEEEEEEEC-CCCCCH---- T ss_conf 8998179844899999986281066----5355----------20015778899-99887999999866-899300---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .|+|+-|.+++.+|-. +.+|..-+-.+...-..+ T Consensus 63 -~~l~~~~~~~a~~~ilvydit~~~Sf~~-i~~w~~e~~~~~~~~~~~-------------------------------- 108 (172) T cd01862 63 -QSLGVAFYRGADCCVLVYDVTNPKSFES-LDSWRDEFLIQASPSDPE-------------------------------- 108 (172) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHHHH-HHHHHHHHHHHCCCCCCC-------------------------------- T ss_conf -3577887238967999985698557899-999999999863877788-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC-CEEEEECCCCCCCHHHH Q ss_conf 453213688875326789507999618755678886358855689999999999998718-41255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHG-ASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYG-AsLiYTS~~~~~nl~~L 284 (523) .+|+++|.+||| |+.++.-..++ .+.||-.+| +..|.||++...|.+.+ T Consensus 109 -----------------~iP~ilVGnK~D----l~~~r~v~~~e-------~~~~a~~~~~~~~~e~SAk~~~nV~e~ 158 (172) T cd01862 109 -----------------NFPFVVLGNKID----LEEKRQVSTKK-------AQQWCQSNGNIPYFETSAKEAINVEQA 158 (172) T ss_pred -----------------CCEEEEECCCCC----HHHHCCCCHHH-------HHHHHHHHCCCEEEEEEECCCCCHHHH T ss_conf -----------------607999714100----01211531789-------999999707960799860489787899 No 35 >cd04112 Rab26 Rab26 subfamily. First identified in rat pancreatic acinar cells, Rab26 is believed to play a role in recruiting mature granules to the plasma membrane upon beta-adrenergic stimulation. Rab26 belongs to the Rab functional group III, which are considered key regulators of intracellular vesicle transport during exocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=97.73 E-value=0.00073 Score=42.48 Aligned_columns=153 Identities=16% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+-||++|+...-..+ -.+.....-- |..|....|.-++.. .++.+|=.+..+.+ T Consensus 3 Iv~iGd~~VGKTsli~r~~~~~---f~~~~~~~Ti--------g~~~~~k~i~~~~~~---i~l~iwDtaGqe~~----- 63 (191) T cd04112 3 VMLLGDSGVGKTCLLVRFKDGA---FLNGNFIATV--------GIDFRNKVVTVDGVK---VKLQIWDTAGQERF----- 63 (191) T ss_pred EEEEECCCCCHHHHHHHHHCCC---CCCCCCCCEE--------EEEEEEEEEEECCEE---EEEEEEECCCCHHH----- T ss_conf 8998269954899998876282---2587634211--------100367789887938---99998755887012----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..+.++ .++|+-|.+.+.+|-. |..|+.-++++-.. T Consensus 64 -~~l~~~yy~~a~~~iivyDit~~~Sf~~-i~~w~~~i~~~~~~------------------------------------ 105 (191) T cd04112 64 -RSVTHAYYRDAHALLLLYDITNKASFDN-IRAWLTEIKEYAQE------------------------------------ 105 (191) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHHHH-HHHHHHHHHHHCCC------------------------------------ T ss_conf -4553666138977999987799789999-99999988852699------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|+++|-+|+| |+.++.-..++. +.+|-++|+..|.||++...|...+.+ T Consensus 106 -----------------~~~ivlVGNK~D----L~~~r~V~~~e~-------~~~a~~~~~~~~EtSAk~~~nI~e~F~ 156 (191) T cd04112 106 -----------------DVVIMLLGNKAD----MSGERVVKREDG-------ERLAKEYGVPFMETSAKTGLNVELAFT 156 (191) T ss_pred -----------------CCEEEEEEECCC----CCCCCCCCHHHH-------HHHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf -----------------948999863277----632255388999-------999996699599996258988889999 No 36 >cd00157 Rho Rho (Ras homology) family. Members of the Rho family include RhoA, Cdc42, Rac, Rnd, Wrch1, RhoBTB, and Rop. There are 22 human Rho family members identified currently. These proteins are all involved in the reorganization of the actin cytoskeleton in response to external stimuli. They also have roles in cell transformation by Ras in cytokinesis, in focal adhesion formation and in the stimulation of stress-activated kinase. These various functions are controlled through distinct effector proteins and mediated through a GTP-binding/GTPase cycle involving three classes of regulating proteins: GAPs (GTPase-activating proteins), GEFs (guanine nucleotide exchange factors), and GDIs (guanine nucleotide dissociation inhibitors). Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho protein Probab=97.73 E-value=0.00027 Score=45.17 Aligned_columns=165 Identities=13% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|..+.||++|+..+....-...- .|-+...|-... ..++....+.+|=. .|...|..+ T Consensus 2 Ki~liGd~~VGKTsli~r~~~~~f~~~~--------~~Ti~~~~~~~i--------~~~~~~~~l~iwDt-~G~e~~~~l 64 (171) T cd00157 2 KIVVVGDGAVGKTCLLISYTTGKFPTEY--------VPTVFDNYSATV--------TVDGKQVNLGLWDT-AGQEEYDRL 64 (171) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCC--------CCEEEEEEEEEE--------EECCEEEEEEEEEC-CCCHHHHHH T ss_conf 7899807995489999998638316653--------432652145578--------75567999999606-774346789 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+....--.. ++++-|.+.+.+|-.-+.+|+..++.+.. T Consensus 65 ~~~~~~~a~~----~ilvydit~~~Sf~~~~~~w~~~i~~~~~------------------------------------- 103 (171) T cd00157 65 RPLSYPNTDV----FLICFSVDSPSSFENVKTKWIPEIRHYCP------------------------------------- 103 (171) T ss_pred HHHHHCCCCE----EEEEEECCCHHHHHHHHHHHHHHHHHHCC------------------------------------- T ss_conf 8987328985----89997168865899999998999998468------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC-EEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184-125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGA-SLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGA-sLiYTS~~~~~nl~~Llh 286 (523) .+|+++|.+|+|..+.-+-.....+.+--.-.+-.+.+|-++|+ ..|.||.+...|...+.. T Consensus 104 -----------------~~piilVgnK~DL~~~~~~~~~~~~~~r~Vs~~e~~~~a~~~~~~~f~EtSAktg~nV~e~F~ 166 (171) T cd00157 104 -----------------NVPIILVGTKIDLRDDENTLKKLEKGKEPITPEEGEKLAKEIGAIGYMECSALTQEGVKEVFE 166 (171) T ss_pred -----------------CCEEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------956999853744212112232210135778989999999973995278875048988789999 Q ss_pred H Q ss_conf 3 Q Fun_An_XP_0013 287 S 287 (523) Q Consensus 287 ~ 287 (523) . T Consensus 167 ~ 167 (171) T cd00157 167 E 167 (171) T ss_pred H T ss_conf 9 No 37 >cd04106 Rab23_lke Rab23-like subfamily. Rab23 is a member of the Rab family of small GTPases. In mouse, Rab23 has been shown to function as a negative regulator in the sonic hedgehog (Shh) signalling pathway. Rab23 mediates the activity of Gli2 and Gli3, transcription factors that regulate Shh signaling in the spinal cord, primarily by preventing Gli2 activation in the absence of Shh ligand. Rab23 also regulates a step in the cytoplasmic signal transduction pathway that mediates the effect of Smoothened (one of two integral membrane proteins that are essential components of the Shh signaling pathway in vertebrates). In humans, Rab23 is expressed in the retina. Mice contain an isoform that shares 93% sequence identity with the human Rab23 and an alternative splicing isoform that is specific to the brain. This isoform causes the murine open brain phenotype, indicating it may have a role in the development of the central nervous system. GTPase activating proteins (GAPs) interact with G Probab=97.72 E-value=0.00081 Score=42.20 Aligned_columns=152 Identities=18% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+-.. ++..-- |..|.--.|.-.+.... -++.+|=. .|.-.+..+. T Consensus 3 i~~iGd~~vGKTsli~r~~~~~f~~----~~~~Ti--------g~~~~~k~v~v~~~~~~-v~l~iwDt-~g~e~~~~~~ 68 (162) T cd04106 3 VIVVGNGNVGKSSMIQRFVKGIFTK----DYKKTI--------GVDFLEKQIFLRQSDED-VRLMLWDT-AGQEEFDAIT 68 (162) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCC----CCCCCC--------CEEEEEEEEEEEECCEE-EEEEEECC-CCCCHHHHHH T ss_conf 8998079844899999986282275----556410--------10467778997008847-99998718-8880034553 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--. .++|+-|-+.+.+| +.+..|..-+++... T Consensus 69 ~~~~~~~~----~~llvydvt~~~Sf-~~i~~w~~~i~~~~~-------------------------------------- 105 (162) T cd04106 69 KAYYRGAQ----ACILVFSTTDRESF-EAIESWKEKVEAECG-------------------------------------- 105 (162) T ss_pred HHHCCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHHCC-------------------------------------- T ss_conf 76414897----89999866997899-999999999998549-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|-+|+| |..++....++ .+.+|-++|+..|-||++...|...+ T Consensus 106 ----------------~~p~ilVGNK~D----l~~~~~vs~~~-------~~~~a~~~~~~~~E~SAk~~~nV~e~ 154 (162) T cd04106 106 ----------------DIPMVLVQTKID----LLDQAVITNEE-------AEALAKRLQLPLFRTSVKDDFNVTEL 154 (162) T ss_pred ----------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------937999821423----21246589899-------99999966995999971589887899 No 38 >cd01861 Rab6 Rab6 subfamily. Rab6 is involved in microtubule-dependent transport pathways through the Golgi and from endosomes to the Golgi. Rab6A of mammals is implicated in retrograde transport through the Golgi stack, and is also required for a slow, COPI-independent, retrograde transport pathway from the Golgi to the endoplasmic reticulum (ER). This pathway may allow Golgi residents to be recycled through the ER for scrutiny by ER quality-control systems. Yeast Ypt6p, the homolog of the mammalian Rab6 GTPase, is not essential for cell viability. Ypt6p acts in endosome-to-Golgi, in intra-Golgi retrograde transport, and possibly also in Golgi-to-ER trafficking. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Probab=97.72 E-value=0.0006 Score=43.01 Aligned_columns=151 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+... ++.--- |..|.-..|.-++.. .++.+|=. .|...|..|. T Consensus 3 I~~iG~~~vGKTsli~r~~~~~f~~----~~~~Ti--------g~~~~~k~i~~~~~~---v~l~i~Dt-~G~e~~~~l~ 66 (161) T cd01861 3 LVFLGDQSVGKTSIITRFMYDTFDN----QYQATI--------GIDFLSKTMYLEDKT---VRLQLWDT-AGQERFRSLI 66 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEEEECCEE---EEEEEECC-CCCHHHHHHH T ss_conf 8998179855899999886381266----557434--------336888899887939---99998517-8842577888 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--.. +||+-|.+++=+| +.+.+|+.-+++.... T Consensus 67 ~~~~~~~~~----~ilvyd~t~~~Sf-~~~~~w~~~i~~~~~~------------------------------------- 104 (161) T cd01861 67 PSYIRDSSV----AVVVYDITNRQSF-DNTDKWIDDVRDERGN------------------------------------- 104 (161) T ss_pred HHHCCCCCC----EEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------- T ss_conf 986038881----7999853987689-9999999888862399------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|.+|+| |..++. .-.+-.+.++-++|+..|-||++...|...+ T Consensus 105 ----------------~~~iilVgNK~D----l~~~~~-------v~~~~~~~~a~~~~~~~~E~Sak~~~nV~e~ 153 (161) T cd01861 105 ----------------DVIIVLVGNKTD----LSDKRQ-------VSTEEGEKKAKELNAMFIETSAKAGHNVKEL 153 (161) T ss_pred ----------------CCEEEEEECCCC----HHHCCC-------CCHHHHHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------978999715533----212136-------7688999999965993999971489787899 No 39 >cd01863 Rab18 Rab18 subfamily. Mammalian Rab18 is implicated in endocytic transport and is expressed most highly in polarized epithelial cells. However, trypanosomal Rab, TbRAB18, is upregulated in the BSF (Blood Stream Form) stage and localized predominantly to elements of the Golgi complex. In human and mouse cells, Rab18 has been identified in lipid droplets, organelles that store neutral lipids. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of mos Probab=97.71 E-value=0.0005 Score=43.51 Aligned_columns=155 Identities=23% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+-.. +..- -.|.-|. ...-..+....++++|=. .|.-.+..|. T Consensus 3 iv~iG~~~VGKTsli~r~~~~~f~~----~~~~----------Ti~~~~~-~k~i~~~~~~~~l~iwDt-~G~e~~~~l~ 66 (161) T cd01863 3 ILLIGDSGVGKSSLLLRFTDDTFDP----DLAA----------TIGVDFK-VKTLTVDGKKVKLAIWDT-AGQERFRTLT 66 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEE-EEEEEECCEEEEEEEEEC-CCCCHHHHHH T ss_conf 8998079965899999986282077----6565----------1000245-889989896999999754-8871012454 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--+ .++++-|.+.+-++-. +++|+.-++.+..+-+ T Consensus 67 ~~~~~~~~----~~i~vfd~t~~~Sf~~-i~~w~~~i~~~~~~~~----------------------------------- 106 (161) T cd01863 67 SSYYRGAQ----GVILVYDVTRRDTFTN-LETWLNELETYSTNND----------------------------------- 106 (161) T ss_pred HHHCCCCC----EEEEEEECCCHHHHHH-HHHHHHHHHHHCCCCC----------------------------------- T ss_conf 75435998----7999985698679999-9999999997338999----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) +|+++|.+|+|. +.-.....-.+++|.++|+..|.||++...|...+.+.. T Consensus 107 -----------------~~~ilvGNK~Dl------------~~r~v~~~e~~~~a~~~~~~~~e~SAk~~~nv~e~F~~l 157 (161) T cd01863 107 -----------------IVKMLVGNKIDK------------ENREVTREEGLKFARKHNMLFIETSAKTRDGVQQAFEEL 157 (161) T ss_pred -----------------CEEEEECCCCCC------------CCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH T ss_conf -----------------389996123343------------000488889999999669929999705897878999999 No 40 >cd04109 Rab28 Rab28 subfamily. First identified in maize, Rab28 has been shown to be a late embryogenesis-abundant (Lea) protein that is regulated by the plant hormone abcisic acid (ABA). In Arabidopsis, Rab28 is expressed during embryo development and is generally restricted to provascular tissues in mature embryos. Unlike maize Rab28, it is not ABA-inducible. Characterization of the human Rab28 homolog revealed two isoforms, which differ by a 95-base pair insertion, producing an alternative sequence for the 30 amino acids at the C-terminus. The two human isoforms are presumbly the result of alternative splicing. Since they differ at the C-terminus but not in the GTP-binding region, they are predicted to be targeted to different cellular locations. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs Probab=97.70 E-value=0.0017 Score=40.21 Aligned_columns=162 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|+.+.||++|+.......-.. .+.. -+|.-|+.-.=.=.+....++.+|=.+.-+.+..-+- T Consensus 3 VvliGd~~VGKTSLi~rf~~~~F~~----~y~~----------Tig~d~~~k~i~i~~~~~v~l~iwDtaGqe~~~~~~~ 68 (215) T cd04109 3 IVVLGDGAVGKTSLCRRFAKEGFGK----SYKQ----------TIGLDFFSKRVTLPGNLNVTLQVWDIGGQSIGGKMLD 68 (215) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEEEEEEEECCCCEEEEEEEECCCCCHHHHHHH T ss_conf 8998269853899998877072177----6465----------1456787899997586058999986477302368899 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) .|...+. .++|+-|-+.+.+| +.|..|+..+++........ T Consensus 69 ~y~~~a~-----~~ilVYdIt~~~SF-~~i~~W~~~i~~~~~~~~~~--------------------------------- 109 (215) T cd04109 69 KYIYGAH-----AVFLVYDVTNSQSF-ENLEDWYSMVRKVLKSSETQ--------------------------------- 109 (215) T ss_pred HHHCCCC-----EEEEEEECCCHHHH-HHHHHHHHHHHHHHHCCCCC--------------------------------- T ss_conf 8705998-----48999753897689-99999999999873105898--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCH----HHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103----456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSL----QSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl----~~L 284 (523) ++|++|-.|+|. +..+....|+- +.||-++|+..|.||.+...|. +.| T Consensus 110 -----------------~~iiLVGNK~DL----~~~R~Vs~ee~-------~~~A~~~~~~f~EvSAktg~nV~elF~~l 161 (215) T cd04109 110 -----------------PLVVLVGNKTDL----EHNRTVKDDKH-------ARFAQANGMESCLVSAKTGDRVNLLFQQL 161 (215) T ss_pred -----------------CEEEEECCCCCH----HHCCCCCHHHH-------HHHHHHCCCCEEEEECCCCCCHHHHHHHH T ss_conf -----------------189996054240----12066798999-------99999649959999626798888999999 Q ss_pred HHHHCCC Q ss_conf 5532253 Q Fun_An_XP_0013 285 IHSSLGI 291 (523) Q Consensus 285 lh~~lgi 291 (523) +-+.+|+ T Consensus 162 a~~i~~~ 168 (215) T cd04109 162 AAELLGV 168 (215) T ss_pred HHHHHCC T ss_conf 9998086 No 41 >cd04152 Arl4_Arl7 Arl4/Arl7 subfamily. Arl4 (Arf-like 4) is highly expressed in testicular germ cells, and is found in the nucleus and nucleolus. In mice, Arl4 is developmentally expressed during embryogenesis, and a role in somite formation and central nervous system differentiation has been proposed. Arl7 has been identified as the only Arf/Arl protein to be induced by agonists of liver X-receptor and retinoid X-receptor and by cholesterol loading in human macrophages. Arl7 is proposed to play a role in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Older literature suggests that Arl6 is a part of the Arl4/Arl7 subfamily, but analyses based on more recent sequence data place Arl6 in its own subfamily. Probab=97.69 E-value=0.0011 Score=41.27 Aligned_columns=154 Identities=18% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .||++|..+.|||||+..+...+.....+.. |..+..+.+--.+..+ .++.+|=+ .|.-.| T Consensus 5 kIvilG~~~~GKTsil~r~~~~~~~~~~pT~-------------g~~~~~~~~~~~~~~~--v~l~iwD~-aGqe~~--- 65 (183) T cd04152 5 HIVMLGLDSAGKTTVLYRLKFNEFVNTVPTK-------------GFNTEKIKVSLGNSKG--ITFHFWDV-GGQEKL--- 65 (183) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCEECCE-------------EEEEEEEEEEECCCCE--EEEEEEEC-CCCHHH--- T ss_conf 9999850898689988876448211100220-------------3347889875047742--79999864-885025--- Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 0110581012003-343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) -.+.+.-++++ -+|+|+|-|+. +++..+..+|.+.+..-... T Consensus 66 --r~l~~~yy~~a~giI~V~D~sd~----~~~~~~~~~l~~i~~~~~~~------------------------------- 108 (183) T cd04152 66 --RPLWKSYTRCTDGIVFVVDSVDV----ERMEEAKTELHKITRFSENQ------------------------------- 108 (183) T ss_pred --HHHHHHHCCCCCEEEEEEECCCH----HHHHHHHHHHHHHHHCCCCC------------------------------- T ss_conf --67553113688679999853783----46899999999997112678------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCH---HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHH Q ss_conf 6453213688875326789507999618755---6788863588556899999999999987184125521233210345 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGADK---IEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQS 283 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~---i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~ 283 (523) ++|+++|..|+|. ++.-|-++ +..++.++-.++.-++.||++--.++.. T Consensus 109 ------------------~~piLi~~NK~Dl~~~~~~~e~~~----------~~~l~~~~~~~~~~~~~~SA~tG~Gi~e 160 (183) T cd04152 109 ------------------GVPVLVLANKQDLPNALSVSEVEK----------LLALHELSASTPWHVQPACAIIGEGLQE 160 (183) T ss_pred ------------------CCEEEEEECCCCCCCCCCHHHHHH----------HHHHHHHHHCCCCEEEEEECCCCCCHHH T ss_conf ------------------978999961678764678899999----------9888999851896798740467878889 Q ss_pred HH Q ss_conf 65 Q Fun_An_XP_0013 284 LI 285 (523) Q Consensus 284 Ll 285 (523) .. T Consensus 161 ~f 162 (183) T cd04152 161 GL 162 (183) T ss_pred HH T ss_conf 99 No 42 >cd01860 Rab5_related Rab5-related subfamily. This subfamily includes Rab5 and Rab22 of mammals, Ypt51/Ypt52/Ypt53 of yeast, and RabF of plants. The members of this subfamily are involved in endocytosis and endocytic-sorting pathways. In mammals, Rab5 GTPases localize to early endosomes and regulate fusion of clathrin-coated vesicles to early endosomes and fusion between early endosomes. In yeast, Ypt51p family members similarly regulate membrane trafficking through prevacuolar compartments. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence mo Probab=97.67 E-value=0.00091 Score=41.91 Aligned_columns=153 Identities=16% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.|||+|+..+-..+-.. ++.. -+|..|..-.= ..++....+++|=. .|.-.+..|. T Consensus 4 i~iiG~~gvGKTsli~r~~~~~f~~----~~~p----------Tig~~~~~k~i-~~~~~~v~l~i~Dt-~G~e~~~~l~ 67 (163) T cd01860 4 LVLLGDSSVGKSSLVLRFVKNEFSE----NQES----------TIGAAFLTQTV-NLDDTTVKFEIWDT-AGQERYRSLA 67 (163) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CCCCEEEEEEE-EECCEEEEEEEECC-CCCHHHHHHH T ss_conf 9998169965899999886283375----5351----------01322568899-88887999997048-9831245666 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +....- -..++|+-|.+.+=++-. +..|+.-++.+... T Consensus 68 ~~~~~~----a~~~ilvydit~~~Sf~~-i~~w~~~i~~~~~~------------------------------------- 105 (163) T cd01860 68 PMYYRG----AAAAIVVYDITSEESFEK-AKSWVKELQRNASP------------------------------------- 105 (163) T ss_pred HHHHCC----CCEEEEEEECCCHHHHHH-HHHHHHHHHHHCCC------------------------------------- T ss_conf 765138----884999986599789999-99988765530699------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|+++|.+|+| |+.++....++ .+.+|-++|+..|.||++...|...+.. T Consensus 106 ----------------~~~iilVgNK~D----l~~~r~v~~~e-------~~~~a~~~~~~~~e~SAk~~~nI~~~F~ 156 (163) T cd01860 106 ----------------NIIIALVGNKAD----LESKRQVSTEE-------AQEYADENGLLFFETSAKTGENVNELFT 156 (163) T ss_pred ----------------CCEEEEEECCHH----HHHCCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHH T ss_conf ----------------958999832210----54305887899-------9999996599299997148988889999 No 43 >cd04132 Rho4_like Rho4-like subfamily. Rho4 is a GTPase that controls septum degradation by regulating secretion of Eng1 or Agn1 during cytokinesis. Rho4 also plays a role in cell morphogenesis. Rho4 regulates septation and cell morphology by controlling the actin cytoskeleton and cytoplasmic microtubules. The localization of Rho4 is modulated by Rdi1, which may function as a GDI, and by Rga9, which is believed to function as a GAP. In S. pombe, both Rho4 deletion and Rho4 overexpression result in a defective cell wall, suggesting a role for Rho4 in maintaining cell wall integrity. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Probab=97.65 E-value=0.0014 Score=40.80 Aligned_columns=161 Identities=18% Q ss_pred EEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHH Q ss_conf 04788647798732123233111124556631225656744443342022331000677455110167871788711232 Q Fun_An_XP_0013 47 KNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAP 126 (523) Q Consensus 47 KnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~ 126 (523) |-|+++|+.+-||++|+-.+...+-.. ++.- -++-.|.--..-..... ..+.+|=. .|.-.|.. T Consensus 1 ~KVvliGd~~VGKTsli~r~~~~~F~~----~~~~----------Ti~~~~~~~~~~~~~~~-v~l~iwDt-aGqe~f~~ 64 (187) T cd04132 1 KKIVVVGDGGCGKTCLLIVYSQGKFPE----EYVP----------TVFENYVTNIQGPNGKI-IELALWDT-AGQEEYDR 64 (187) T ss_pred CEEEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEEEEEEECCCEE-EEEEEECC-CCCHHHHH T ss_conf 968998179832899998876182267----6465----------15767899999738818-99986148-77524577 Q ss_pred HHHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC Q ss_conf 00110581012003-34333000031368999999999999998506958889999999998622688767777767777 Q Fun_An_XP_0013 127 LLKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFT 205 (523) Q Consensus 127 LLk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~ 205 (523) + .+..++++ .++|+-|.+.|.+|-.-+.+|+..+++... T Consensus 65 l-----~~~~~~~a~~~ilvyDit~~~Sf~~~~~~W~~~i~~~~~----------------------------------- 104 (187) T cd04132 65 L-----RPLSYPDVDVLLICYAVDNPTSLDNVEDKWFPEVNHFCP----------------------------------- 104 (187) T ss_pred H-----HHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCC----------------------------------- T ss_conf 8-----887724897589998659978999999877899998458----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC-EEEEECCCCCCCHHHH Q ss_conf 664532136888753267895079996187556788863588556899999999999987184-1255212332103456 Q Fun_An_XP_0013 206 SSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGA-SLIYTTPFLANSLQSL 284 (523) Q Consensus 206 ~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGA-sLiYTS~~~~~nl~~L 284 (523) .+|+++|.+|+|..+.-+..+.-..++- +.++-..|+ .-|-||++...|...+ T Consensus 105 -------------------~~piilVGNK~DL~~~~~~~r~V~~~e~-------~~~a~~~~~~~y~EtSAk~g~nV~e~ 158 (187) T cd04132 105 -------------------GTPIMLVGLKTDLRKDKNLDRKVTPAQA-------ESVAKKQGAFAYLECSAKTMENVEEV 158 (187) T ss_pred -------------------CCEEEEEECCCCCHHHHCCCCCCCHHHH-------HHHHHHCCCCEEEEEEECCCCCHHHH T ss_conf -------------------9779998416751223111367898899-------99999738932689861278887899 Q ss_pred HHHHC Q ss_conf 55322 Q Fun_An_XP_0013 285 IHSSL 289 (523) Q Consensus 285 lh~~l 289 (523) .+... T Consensus 159 F~~l~ 163 (187) T cd04132 159 FDTAI 163 (187) T ss_pred HHHHH T ss_conf 99999 No 44 >cd01865 Rab3 Rab3 subfamily. The Rab3 subfamily contains Rab3A, Rab3B, Rab3C, and Rab3D. All four isoforms were found in mouse brain and endocrine tissues, with varying levels of expression. Rab3A, Rab3B, and Rab3C localized to synaptic and secretory vesicles; Rab3D was expressed at high levels only in adipose tissue, exocrine glands, and the endocrine pituitary, where it is localized to cytoplasmic secretory granules. Rab3 appears to control Ca2+-regulated exocytosis. The appropriate GDP/GTP exchange cycle of Rab3A is required for Ca2+-regulated exocytosis to occur, and interaction of the GTP-bound form of Rab3A with effector molecule(s) is widely believed to be essential for this process. Functionally, most studies point toward a role for Rab3 in the secretion of hormones and neurotransmitters. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promot Probab=97.65 E-value=0.0014 Score=40.71 Aligned_columns=155 Identities=19% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+-.....+-.. ++..-- +..|..-.|...+.. ..+.+|=.+..+-+ T Consensus 4 iilvGd~~VGKTsli~rf~~~~f~~----~y~~Ti--------~~~~~~k~i~~~~~~---v~l~iwDt~G~e~~----- 63 (165) T cd01865 4 LLIIGNSSVGKTSFLFRYADDSFTS----AFVSTV--------GIDFKVKTVFRNDKR---VKLQIWDTAGQERY----- 63 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCCE--------EEEEEEEEEEECCEE---EEEEEEECCCCCHH----- T ss_conf 9998079953899888764481066----634303--------656789999877938---99999745887013----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..+.++ .++|+-|.+.+-+| +.+.+|+.-++..... T Consensus 64 -~~~~~~~~~~~~~~iivfd~t~~~Sf-~~i~~w~~~i~~~~~~------------------------------------ 105 (165) T cd01865 64 -RTITTAYYRGAMGFILMYDITNEESF-NAVQDWSTQIKTYSWD------------------------------------ 105 (165) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -45656433699889999866986689-9999999999860699------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|+++|-+|+|. +++-..-..-.+.+|-++|...|.||++...|...+... T Consensus 106 -----------------~~~iilVGNK~Dl-----------~~~r~v~~~~~~~~a~~~~~~y~EtSAk~~~nV~e~F~~ 157 (165) T cd01865 106 -----------------NAQVILVGNKCDM-----------EDERVVSSERGRQLADQLGFEFFEASAKENINVKQVFER 157 (165) T ss_pred -----------------CEEEEEEECCCCH-----------HHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------6089997217772-----------465531388999999965994999971589887899999 Q ss_pred HC Q ss_conf 22 Q Fun_An_XP_0013 288 SL 289 (523) Q Consensus 288 ~l 289 (523) .. T Consensus 158 l~ 159 (165) T cd01865 158 LV 159 (165) T ss_pred HH T ss_conf 99 No 45 >cd01867 Rab8_Rab10_Rab13_like Rab8/Sec4/Ypt2. Rab8/Sec4/Ypt2 are known or suspected to be involved in post-Golgi transport to the plasma membrane. It is likely that these Rabs have functions that are specific to the mammalian lineage and have no orthologs in plants. Rab8 modulates polarized membrane transport through reorganization of actin and microtubules, induces the formation of new surface extensions, and has an important role in directed membrane transport to cell surfaces. The Ypt2 gene of the fission yeast Schizosaccharomyces pombe encodes a member of the Ypt/Rab family of small GTP-binding proteins, related in sequence to Sec4p of Saccharomyces cerevisiae but closer to mammalian Rab8. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhi Probab=97.64 E-value=0.00047 Score=43.65 Aligned_columns=152 Identities=18% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+...-..+-.. .+...- |..| ....-..++...++.+|=. .|...+ T Consensus 6 i~liGd~~vGKTsli~r~~~~~f~~----~~~~Ti--------g~~~---~~k~v~~~~~~v~l~iwDt-~G~e~~---- 65 (167) T cd01867 6 LLLIGDSGVGKSCLLLRFSEDSFNP----SFISTI--------GIDF---KIRTIELDGKKIKLQIWDT-AGQERF---- 65 (167) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEE---EEEEEEECCEEEEEEEEEC-CCCCHH---- T ss_conf 9998269843899998876381076----556412--------1256---7889998894999999866-898002---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+++.-+.++ .++|+-|.+.+=++ +.++.|+.-++.+... T Consensus 66 -~~~~~~~~~~a~~~iivfDit~~~Sf-~~i~~w~~~i~~~~~~------------------------------------ 107 (167) T cd01867 66 -RTITTAYYRGAMGIILVYDITDEKSF-ENIRNWMRNIEEHASE------------------------------------ 107 (167) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -34537543699889999856984678-9999999999852699------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|+++|-+|+|. ++.-..-.+-.+++|.++|+..|.||++...|...+-+ T Consensus 108 -----------------~~~~ilVGNK~DL-----------~~~r~v~~~~~~~~a~~~~~~~~e~SAk~~~nv~~~F~ 158 (167) T cd01867 108 -----------------DVERMLVGNKCDM-----------EEKRVVSKEEGEALADEYGIKFLETSAKANINVEEAFF 158 (167) T ss_pred -----------------CCEEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH T ss_conf -----------------9389999404675-----------22246698999999996499599997048978789999 No 46 >cd04138 H_N_K_Ras_like H-Ras/N-Ras/K-Ras subfamily. H-Ras, N-Ras, and K-Ras4A/4B are the prototypical members of the Ras family. These isoforms generate distinct signal outputs despite interacting with a common set of activators and effectors, and are strongly associated with oncogenic progression in tumor initiation. Mutated versions of Ras that are insensitive to GAP stimulation (and are therefore constitutively active) are found in a significant fraction of human cancers. Many Ras guanine nucleotide exchange factors (GEFs) have been identified. They are sequestered in the cytosol until activation by growth factors triggers recruitment to the plasma membrane or Golgi, where the GEF colocalizes with Ras. Active (GTP-bound) Ras interacts with several effector proteins that stimulate a variety of diverse cytoplasmic signaling activities. Some are known to positively mediate the oncogenic properties of Ras, including Raf, phosphatidylinositol 3-kinase (PI3K), RalGEFs, and Tiam1. Probab=97.63 E-value=0.0014 Score=40.67 Aligned_columns=151 Identities=18% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+....-.. ++..-- +-.|.-.-+.|.. ..++++|=.+..+.+ T Consensus 4 vvliGd~~VGKTSli~~~~~~~f~~----~y~~Ti--------~~~~~k~v~i~~~----~~~l~i~Dt~G~e~~----- 62 (162) T cd04138 4 LVVVGAGGVGKSALTIQLIQNHFVD----EYDPTI--------EDSYRKQVVIDGE----TCLLDILDTAGQEEY----- 62 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCC--------EEEEEEEEEECCE----EEEEEEEECCCCHHH----- T ss_conf 8998179954899999986180167----656510--------0147889999895----899998746885013----- Q ss_pred HHCCCHHHHCC-EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200-33433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPE-TLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~-TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..+++ ..++|+.|.+++=+| +.+..|...+.+.-.+- T Consensus 63 -~~~~~~~~~~a~~~ilvydv~~~~Sf-~~i~~w~~~i~~~~~~~----------------------------------- 105 (162) T cd04138 63 -SAMRDQYMRTGEGFLCVFAINSRKSF-EDIHTYREQIKRVKDSD----------------------------------- 105 (162) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCCC----------------------------------- T ss_conf -46648752389769999866997899-99999999998741899----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|+++|.+|+|. .++....++ .+.+|-++|+.-|-||++...|...+.+ T Consensus 106 -----------------~~piilvgNK~Dl-----~~r~v~~~e-------~~~~a~~~~~~~~E~SAkt~~nV~e~F~ 155 (162) T cd04138 106 -----------------DVPMVLVGNKCDL-----AARTVSSRQ-------GQDLAKSYGIPYIETSAKTRQGVEEAFY 155 (162) T ss_pred -----------------CCEEEEEEEECCC-----CCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf -----------------9489998300475-----332589899-------9999996699599997048978789999 No 47 >cd04155 Arl3 Arl3 subfamily. Arl3 (Arf-like 3) is an Arf family protein that differs from most Arf family members in the N-terminal extension. In is inactive, GDP-bound form, the N-terminal extension forms an elongated loop that is hydrophobically anchored into the membrane surface; however, it has been proposed that this region might form a helix in the GTP-bound form. The delta subunit of the rod-specific cyclic GMP phosphodiesterase type 6 (PDEdelta) is an Arl3 effector. Arl3 binds microtubules in a regulated manner to alter specific aspects of cytokinesis via interactions with retinitis pigmentosa 2 (RP2). It has been proposed that RP2 functions in concert with Arl3 to link the cell membrane and the cytoskeleton in photoreceptors as part of the cell signaling or vesicular transport machinery. In mice, the absence of Arl3 is associated with abnormal epithelial cell proliferation and cyst formation. Probab=97.63 E-value=0.00073 Score=42.50 Aligned_columns=152 Identities=18% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .||++|..++|||||+..+.........+.. |..+..++..+ .++.+|=+ .|.-.+..+ T Consensus 16 kiliiG~~~~GKTsll~~l~~~~~~~~~pT~-------------g~~~~~i~~~~-------~~l~~wD~-~G~~~~r~~ 74 (173) T cd04155 16 RILILGLDNAGKTTILKQLASEDISHITPTQ-------------GFNIKTVQSDG-------FKLNVWDI-GGQRAIRPY 74 (173) T ss_pred EEEEEEECCCCHHHHHHHHHCCCCCEEEEEE-------------EEEEEEEEECC-------EEEEEEEC-CCHHHHHHH T ss_conf 6999840898689988888469522144112-------------35889987188-------89999866-872567999 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+....-- -.+|+|+|-+++-.+-+....+..+|++.-.+ T Consensus 75 ~~~y~~~a----~~iI~VvD~sd~~~~~~~~~~l~~~L~~~~~~------------------------------------ 114 (173) T cd04155 75 WRNYFENT----DCLIYVIDSADKKRLEEAGAELVELLEEEKLA------------------------------------ 114 (173) T ss_pred HHHHCCCC----CEEEEEEECCCHHHHHHHHHHHHHHHHHHCCC------------------------------------ T ss_conf 99860667----46899986578445899999999987300338------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH-HCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987-184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLK-HGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLq-YGAsLiYTS~~~~~nl~~Llh 286 (523) ++|++|++.|+|.-..+..+. |.+.+.-..++ -.-..++||.+.-.+++..+. T Consensus 115 -----------------~~PiLi~~NK~Dl~~~~~~~e---------i~~~l~l~~~~~~~~~i~~~SA~tGeGI~e~~~ 168 (173) T cd04155 115 -----------------GVPVLVFANKQDLATAAPAEE---------IAEALNLHDLRDRTWHIQACSAKTGEGLQEGMN 168 (173) T ss_pred -----------------CCEEEEEEECCCCCCCCCHHH---------HHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH T ss_conf -----------------947999970578543689899---------999975786428946999875235888899999 No 48 >cd04175 Rap1 Rap1 subgroup. The Rap1 subgroup is part of the Rap subfamily of the Ras family. It can be further divided into the Rap1a and Rap1b isoforms. In humans, Rap1a and Rap1b share 95% sequence homology, but are products of two different genes located on chromosomes 1 and 12, respectively. Rap1a is sometimes called smg p21 or Krev1 in the older literature. Rap1 proteins are believed to perform different cellular functions, depending on the isoform, its subcellular localization, and the effector proteins it binds. For example, in rat salivary gland, neutrophils, and platelets, Rap1 localizes to secretory granules and is believed to regulate exocytosis or the formation of secretory granules. Rap1 has also been shown to localize in the Golgi of rat fibroblasts, zymogen granules, plasma membrane, and the microsomal membrane of pancreatic acini, as well as in the endocytic compartment of skeletal muscle cells and fibroblasts. High expression of Rap1 has been observed in the n Probab=97.62 E-value=0.00099 Score=41.67 Aligned_columns=153 Identities=18% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+ ....-.|-+.+.|.-.. ..++....+.+|=. .|...|..+. T Consensus 4 ivlvGd~~VGKTsli~r~~~~~--------f~~~y~~Ti~~~~~k~i--------~~~~~~~~l~iwDt-aG~e~~~~~~ 66 (164) T cd04175 4 LVVLGSGGVGKSALTVQFVQGI--------FVEKYDPTIEDSYRKQV--------EVDGQQCMLEILDT-AGTEQFTAMR 66 (164) T ss_pred EEEEECCCCCHHHHHHHHHCCC--------CCCCCCCCCCCEEEEEE--------EECCEEEEEEEEEC-CCCCHHHHHH T ss_conf 8998079853899999986280--------06655753121368999--------88894899998727-9982023576 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.- -..+|++-|.+.+.+| +.|..|..-++.....- T Consensus 67 ~~~~~~----a~~~ilvydit~~~Sf-~~i~~~~~~i~~~~~~~------------------------------------ 105 (164) T cd04175 67 DLYMKN----GQGFVLVYSITAQSTF-NDLQDLREQILRVKDTE------------------------------------ 105 (164) T ss_pred HHHCCC----CCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCCC------------------------------------ T ss_conf 755058----9879999866997788-99999988888640899------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|+++|.+|+| |+.++.-..++ ...+|-++|+..|-||++...|...+.. T Consensus 106 ----------------~ip~vlvGNK~D----L~~~r~V~~~~-------~~~~a~~~~~~~~E~Sak~~~nV~e~F~ 156 (164) T cd04175 106 ----------------DVPMILVGNKCD----LEDERVVGKEQ-------GQNLARQWGCAFLETSAKAKINVNEIFY 156 (164) T ss_pred ----------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf ----------------857999812565----30003340789-------9999996599389997147988789999 No 49 >smart00174 RHO Rho (Ras homology) subfamily of Ras-like small GTPases; Members of this subfamily of Ras-like small GTPases include Cdc42 and Rac, as well as Rho isoforms. Probab=97.59 E-value=0.00039 Score=44.15 Aligned_columns=162 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |++||..+.||++|+..+...+-...- .|-|...|..-. ..++...++.+|=. .|...| T Consensus 1 ivliGd~~VGKTsli~rf~~~~f~~~~--------~pTi~~~~~~~i--------~~~~~~v~l~iwDt-aGqe~~---- 59 (174) T smart00174 1 LVVVGDGAVGKTCLLISYTTNAFPEDY--------VPTVFENYSADV--------EVDGKPVELGLWDT-AGQEDY---- 59 (174) T ss_pred CEEECCCCCCHHHHHHHHHCCCCCCCC--------CCEEEEEEEEEE--------EECCEEEEEEECCC-CCCCHH---- T ss_conf 678715983389999998618226662--------551543246755--------57786799986466-666223---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..+.++ .+||+-|.+++.+|-.=..+|+..++.+.. T Consensus 60 -~~l~~~~y~~a~~~ilvydit~~~Sf~~l~~~W~~~i~~~~~------------------------------------- 101 (174) T smart00174 60 -DRLRPLSYPDTDVFLICFSVDSPASFENVKEKWYPEVKHFCP------------------------------------- 101 (174) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCC------------------------------------- T ss_conf -566687643883689998638865789999988999998478------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHH-HHHHHHHHHHHCCEEEE-ECCCCCCCHHHHH Q ss_conf 453213688875326789507999618755678886358855689999-99999999871841255-2123321034565 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFI-LQFMRTLLLKHGASLIY-TTPFLANSLQSLI 285 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfI-qQ~lRt~cLqYGAsLiY-TS~~~~~nl~~Ll 285 (523) .+|+++|-+|+|..+.-+.-...++++--.| .+..+.+|-++|+-.|| ||.+...|...+. T Consensus 102 -----------------~~piiLVGnK~DL~~~~~~~~~~~~~~~~~vs~~e~~~~a~~~~~~~y~EtSAktg~nV~e~F 164 (174) T smart00174 102 -----------------NVPIILVGTKLDLRNDEDTLEELSKKKQEPVTYEQGEALAKRIGAVKYIECSALTQEGVREVF 164 (174) T ss_pred -----------------CCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH T ss_conf -----------------966999715656320134555543101356888899999997189416887504887878999 Q ss_pred H Q ss_conf 5 Q Fun_An_XP_0013 286 H 286 (523) Q Consensus 286 h 286 (523) + T Consensus 165 ~ 165 (174) T smart00174 165 E 165 (174) T ss_pred H T ss_conf 9 No 50 >cd00878 Arf_Arl Arf (ADP-ribosylation factor)/Arl (Arf-like) small GTPases. Arf proteins are activators of phospholipase D isoforms. Unlike Ras proteins they lack cysteine residues at their C-termini and therefore are unlikely to be prenylated. Arfs are N-terminally myristoylated. Members of the Arf family are regulators of vesicle formation in intracellular traffic that interact reversibly with membranes of the secretory and endocytic compartments in a GTP-dependent manner. They depart from other small GTP-binding proteins by a unique structural device, interswitch toggle, that implements front-back communication from N-terminus to the nucleotide binding site. Arf-like (Arl) proteins are close relatives of the Arf, but only Arl1 has been shown to function in membrane traffic like the Arf proteins. Arl2 has an unrelated function in the folding of native tubulin, and Arl4 may function in the nucleus. Most other Arf family proteins are so far relatively poorly characterized. Thu Probab=97.58 E-value=0.00083 Score=42.13 Aligned_columns=152 Identities=16% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) ||+||..+.||++|+..+.........+.. |..|..++... .++.+|=+ .|.-.+..+. T Consensus 2 iviiG~~~vGKTsli~~~~~~~~~~~~pTi-------------g~~~~~i~~~~-------~~~~i~D~-~G~~~~~~l~ 60 (158) T cd00878 2 ILILGLDGAGKTTILYKLKLGEVVTTIPTI-------------GFNVETVEYKN-------VSFTVWDV-GGQDKIRPLW 60 (158) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCEEEEE-------------EEEEEEEECCC-------EEEEEEEC-CCCCCCHHHH T ss_conf 788843998789999998648233122025-------------42688853041-------48999865-8985204677 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--. .+|+|.|.|++ +++..+..++.+.+...... T Consensus 61 ~~y~~~a~----~iI~V~D~sd~----~s~~~~~~~~~~~~~~~~~~--------------------------------- 99 (158) T cd00878 61 KHYYENTN----GIIFVVDSSDR----ERIEEAKEELHKLLNEEELK--------------------------------- 99 (158) T ss_pred HHHCCCCC----EEEEEEECCCC----CCHHHHHHHHHHHHHHCCCC--------------------------------- T ss_conf 86614898----17999843776----55789999999985211448--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ++|++||++|+|.-..+..+ +..+..=..-+.+..-..|.||++-..++..... T Consensus 100 ----------------~~pili~~NK~Dl~~~~~~~--------ei~~~~~l~~~~~~~~~~~~~SAktg~gI~e~f~ 153 (158) T cd00878 100 ----------------GVPLLIFANKQDLPGALSVS--------ELIEKLGLEKILGRRWHIQPCSAVTGDGLDEGLD 153 (158) T ss_pred ----------------CCEEEEEEECCCCCCCCCHH--------HHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHH T ss_conf ----------------94367554011653347988--------9999987777605964899875125878899999 No 51 >cd04121 Rab40 Rab40 subfamily. This subfamily contains Rab40a, Rab40b, and Rab40c, which are all highly homologous. In rat, Rab40c is localized to the perinuclear recycling compartment (PRC), and is distributed in a tissue-specific manor, with high expression in brain, heart, kidney, and testis, low expression in lung and liver, and no expression in spleen and skeletal muscle. Rab40c is highly expressed in differentiated oligodendrocytes but minimally expressed in oligodendrocyte progenitors, suggesting a role in the vesicular transport of myelin components. Unlike most other Ras-superfamily proteins, Rab40c was shown to have a much lower affinity for GTP, and an affinity for GDP that is lower than for GTP. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide d Probab=97.58 E-value=0.0019 Score=39.95 Aligned_columns=149 Identities=18% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+-||++|+..+....... .+.-.- |..|....+.-++.. -.+.+|=-+.-.-+ T Consensus 9 IVliGd~~VGKTSLi~rf~~~~f~~----~y~~Ti--------G~d~~~k~i~vdg~~---v~L~IWDTAGqE~f----- 68 (235) T cd04121 9 FLLVGDSDVGKGEILASLQDGSTES----PYGYNM--------GIDYKTTTILLDGRR---VKLQLWDTSGQGRF----- 68 (235) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEEEECCCE---EEEEEEECCCCCHH----- T ss_conf 9998169844788877642581067----634302--------446789999885828---99998746641001----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+++.-+++. .++||-|.+..++|-. +.+|+.-++++.. T Consensus 69 -~sl~~~y~r~A~gvILVYDIT~r~SF~~-i~~W~~ei~~~~~------------------------------------- 109 (235) T cd04121 69 -CTIFRSYSRGAQGIILVYDITNRWSFDG-IDRWIKEIDEHAP------------------------------------- 109 (235) T ss_pred -HCCCHHHHCCCCCEEEEEECCCHHHHHH-HHHHHHHHHHHCC------------------------------------- T ss_conf -1000233214771799987699778999-9999999986328------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) ++|+++|..|+| |+.++.-..|+ -+.||-++|+..|=||+|...|...+ T Consensus 110 -----------------~ipiILVGNK~D----L~~~R~Vs~eE-------g~~~A~~~~~~FfEtSAKtn~NV~E~ 158 (235) T cd04121 110 -----------------GVPKILVGNRLH----LAFKRQVATEQ-------AQAYAERNGMTFFEVSPLCNFNITES 158 (235) T ss_pred -----------------CCEEEEEECCCC----HHHCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf -----------------965999703224----00237779899-------99999966995999853689988899 No 52 >pfam00025 Arf ADP-ribosylation factor family. Pfam combines a number of different Prosite families together Probab=97.57 E-value=0.0016 Score=40.35 Aligned_columns=153 Identities=16% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..++|||+|+..+.........+.. |..+..++..+ ..+.+|-+ .|...+.++- T Consensus 18 ivllG~~~vGKTsli~r~~~~~~~~~~pTi-------------g~~~~~i~~~~-------~~~~iwD~-~G~e~~r~l~ 76 (176) T pfam00025 18 ILMLGLDNAGKTTILYKLKLGEVVTTIPTI-------------GFNVETVTYKN-------VKFTVWDV-GGQESLRPLW 76 (176) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCEEEEEE-------------EEEEEEEEECC-------EEEEEEEC-CCCHHHHHHH T ss_conf 999843998688988876458302022003-------------11588987658-------38999876-9715689998 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +....--.. +|+|+|-|++ ++++.+...+.+.+..-... T Consensus 77 ~~y~~~a~~----iI~V~D~sd~----~~~~~~~~~l~~ll~~~~~~--------------------------------- 115 (176) T pfam00025 77 RNYFPNTDG----VIFVVDSADR----DRIEEAKQELHALLNEEELA--------------------------------- 115 (176) T ss_pred HHHCCCCCE----EEEEEECCCC----CCHHHHHHHHHHHHHCCCCC--------------------------------- T ss_conf 874125227----9999964886----54689999999985001458--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|++||++|+|. .....+++.--+.+.-+ +|-.+.-..|.||++.-.++....+ T Consensus 116 ----------------~~pilI~~NK~Dl------~~~~~~~ei~~~~~l~~-~~~~~~~~~~~~SAktG~GI~E~f~ 170 (176) T pfam00025 116 ----------------DAPLLIFANKQDL------PGAMSEAEIRELLGLHE-LRGSRPWEIQGCSAVTGEGLYEGLD 170 (176) T ss_pred ----------------CCEEEEEEECCCC------CCCCCHHHHHHHHHHHH-HHCCCCEEEEEEEECCCCCHHHHHH T ss_conf ----------------9789999606688------77889899999988898-7238966999875024888899999 No 53 >cd04108 Rab36_Rab34 Rab34/Rab36 subfamily. Rab34, found primarily in the Golgi, interacts with its effector, Rab-interacting lysosomal protein (RILP). This enables its participation in microtubular dynenin-dynactin-mediated repositioning of lysosomes from the cell periphery to the Golgi. A Rab34 (Rah) isoform that lacks the consensus GTP-binding region has been identified in mice. This isoform is associated with membrane ruffles and promotes macropinosome formation. Rab36 has been mapped to human chromosome 22q11.2, a region that is homozygously deleted in malignant rhabdoid tumors (MRTs). However, experimental assessments do not implicate Rab36 as a tumor suppressor that would enable tumor formation through a loss-of-function mechanism. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further re Probab=97.57 E-value=0.0012 Score=41.19 Aligned_columns=157 Identities=13% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+-||++|+.......-.. ++..-- |..|.--.+.-.+.. ..+.+|=. .|...|..+. T Consensus 3 ivliGd~~VGKTsli~rf~~~~f~~----~y~~Ti--------g~d~~~k~~~~~~~~---i~l~iwDt-aG~e~~~~~~ 66 (170) T cd04108 3 VIVVGDLSVGKTCLINRFCKDVFDK----NYKATI--------GVDFEMERFEILGVP---FSLQLWDT-AGQERFKCIA 66 (170) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCEE--------EEEEEEEEEEECCEE---EEEEEEEC-CCCHHHHHHH T ss_conf 8998169854899888876282278----624425--------667889987518837---99998536-8860245666 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +....--+. +||+.|-+.+.++ +.+++|+.-+...-..- T Consensus 67 ~~~~~~a~~----~ilvyDit~~~Sf-~~~~~w~~~~~~~~~~~------------------------------------ 105 (170) T cd04108 67 STYYRGAQA----IIIVFDLTDVASL-EHTRQWLEDALKENDPS------------------------------------ 105 (170) T ss_pred HHHCCCCCE----EEEEEECCCHHHH-HHHHHHHHHHHHHHCCC------------------------------------ T ss_conf 754048880----8999754986578-99999999998740799------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|+++|.+|+|..+. ++-..+.+.-+.++-++|+..|.||++...|...+-+. T Consensus 106 ----------------~~~i~LVGnK~DL~~~---------~~~~~~~~~~~~~a~~~~~~~fEtSAktg~nV~e~F~~ 159 (170) T cd04108 106 ----------------SVLLFLVGTKKDLSSP---------AQYALMEQDAIKLAAEMQAEYWSVSALSGENVREFFFR 159 (170) T ss_pred ----------------CCEEEEEECCCCCCCC---------CCCEECHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf ----------------9689998356010453---------11200378999999965995999972588787899999 No 54 >cd04114 Rab30 Rab30 subfamily. Rab30 appears to be associated with the Golgi stack. It is expressed in a wide variety of tissue types and in humans maps to chromosome 11. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. Probab=97.53 E-value=0.001 Score=41.65 Aligned_columns=151 Identities=11% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+......+... ....-- +..| .+..-..++...++.+|=- .|...+..+. T Consensus 10 ivliGd~~VGKTsli~rf~~~~f~~----~~~~Ti--------~~~~---~~k~~~~~~~~v~l~iwDt-aG~e~~~~~~ 73 (169) T cd04114 10 IVLIGNAGVGKTCLVRRFTQGLFPP----GQGATI--------GVDF---MIKTVEIKGEKIKLQIWDT-AGQERFRSIT 73 (169) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEE---EEEEEEECCEEEEEEEEEC-CCCHHHHHHH T ss_conf 9998269844899999986286785----433112--------2114---7889988895999999865-8980246776 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--. .+||+-|.+.+=++ +.|.+|+.-++++... T Consensus 74 ~~~~~~a~----~~iivydit~~~Sf-~~i~~w~~~i~~~~~~------------------------------------- 111 (169) T cd04114 74 QSYYRSAN----ALILTYDITCEESF-RCLPEWLREIEQYANN------------------------------------- 111 (169) T ss_pred HHHHCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHHHCC------------------------------------- T ss_conf 87604888----38999655984688-9999999999874069------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|.+|+|. .++-..-.+-.+.++-++|...|-||++...|.+.+ T Consensus 112 ----------------~~~iilVGNK~Dl-----------~~~r~v~~~~~~~~a~~~~~~~~e~SAktg~nV~~~ 160 (169) T cd04114 112 ----------------KVITILVGNKIDL-----------AERREVSQQRAEEFSDAQDMYYLETSAKESDNVEKL 160 (169) T ss_pred ----------------CCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHH T ss_conf ----------------9418998114321-----------102365878999999964983999970379888899 No 55 >cd01864 Rab19 Rab19 subfamily. Rab19 proteins are associated with Golgi stacks. Similarity analysis indicated that Rab41 is closely related to Rab19. However, the function of these Rabs is not yet chracterized. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. Probab=97.48 E-value=0.0021 Score=39.62 Aligned_columns=150 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....-.. .+..-- |.+|..-.+.=.+.. ..+.+|=.+..+-+ T Consensus 6 ivivGd~~vGKTsli~rf~~~~F~~----~~~~ti--------g~~~~~k~i~~~~~~---v~l~iwDt~G~e~~----- 65 (165) T cd01864 6 IILIGDSNVGKTCVVQRFKSGTFSE----RQGNTI--------GVDFTMKTLEIEGKR---VKLQIWDTAGQERF----- 65 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEEECCEE---EEEEEEECCCCCHH----- T ss_conf 9998079944899999876282077----667711--------257789999988958---99999754887013----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .++|+.|.+.+-+|.. |++|+.-++++..+ T Consensus 66 -~~l~~~~~~~~~~~ilvydit~~~Sf~~-l~~w~~~i~~~~~~------------------------------------ 107 (165) T cd01864 66 -RTITQSYYRSANGAIIAYDITRRSSFES-VPHWIEEVEKYGAS------------------------------------ 107 (165) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHHHH-HHHHHHHHHHCCCC------------------------------------ T ss_conf -5776864269987999987599779999-99988889851698------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEE-EEECCCCCCCHHHH Q ss_conf 453213688875326789507999618755678886358855689999999999998718412-55212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASL-IYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsL-iYTS~~~~~nl~~L 284 (523) .+|+++|.+|+| |++++.-..++ .+.+|-++|+-- |-||++...|...+ T Consensus 108 -----------------~~~ivlVGNK~D----l~~~r~V~~~~-------~~~~a~~~~~~~~~E~SAk~~~nv~e~ 157 (165) T cd01864 108 -----------------NVVLLLIGNKCD----LEEQREVLFEE-------ACTLAEKNGMLAVLETSAKESQNVEEA 157 (165) T ss_pred -----------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEEEECCCCCHHHH T ss_conf -----------------957999724211----00035545789-------999999649948999740489898899 No 56 >cd01869 Rab1_Ypt1 Rab1/Ypt1 subfamily. Rab1 is found in every eukaryote and is a key regulatory component for the transport of vesicles from the ER to the Golgi apparatus. Studies on mutations of Ypt1, the yeast homolog of Rab1, showed that this protein is necessary for the budding of vesicles of the ER as well as for their transport to, and fusion with, the Golgi apparatus. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to t Probab=97.40 E-value=0.0022 Score=39.48 Aligned_columns=153 Identities=16% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |++||..+.|||+|+..+...+-.. ++..-- +..|....|.-++.. .++.+|=.+..+-+ T Consensus 5 iv~vGd~~vGKTsli~r~~~~~f~~----~y~~Ti--------g~~~~~k~i~~~~~~---v~l~iwDt~G~e~~----- 64 (166) T cd01869 5 LLLIGDSGVGKSCLLLRFADDTYTE----SYISTI--------GVDFKIRTIELDGKT---IKLQIWDTAGQERF----- 64 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEEECCEE---EEEEEEECCCCHHH----- T ss_conf 9998269954899999875380066----657601--------235678899998958---99998626886011----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) -.+.+..++++ .+||+-|.+...++-. +++|+.-++++... T Consensus 65 -~~l~~~~~~~a~~~iivfdit~~~Sf~~-i~~w~~~i~~~~~~------------------------------------ 106 (166) T cd01869 65 -RTITSSYYRGAHGIIIVYDVTDQESFNN-VKQWLQEIDRYASE------------------------------------ 106 (166) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHHHH-HHHHHHHHHHHCCC------------------------------------ T ss_conf -2311212268988999986798568999-99999999872599------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|+++|-+|+|. .+.-+.-.+-.+.++-++|+..|.||.+...|...+.+. T Consensus 107 -----------------~~~~ilVGNK~Dl-----------~~~r~V~~~~~~~~a~~~~~~~~E~Sak~g~~V~e~F~~ 158 (166) T cd01869 107 -----------------NVNKLLVGNKCDL-----------TDKRVVDYSEAQEFADELGIPFLETSAKNATNVEQAFMT 158 (166) T ss_pred -----------------CCEEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------8279998503333-----------324557989999999965995999971489887899999 No 57 >cd04118 Rab24 Rab24 subfamily. Rab24 is distinct from other Rabs in several ways. It exists primarily in the GTP-bound state, having a low intrinsic GTPase activity; it is not efficiently geranyl-geranylated at the C-terminus; it does not form a detectable complex with Rab GDP-dissociation inhibitors (GDIs); and it has recently been shown to undergo tyrosine phosphorylation when overexpressed in vitro. The specific function of Rab24 still remains unknown. It is found in a transport route between ER-cis-Golgi and late endocytic compartments. It is putatively involved in an autophagic pathway, possibly directing misfolded proteins in the ER to degradative pathways. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilita Probab=97.40 E-value=0.0018 Score=40.13 Aligned_columns=153 Identities=13% Q ss_pred EEEECCCCCCCEEHHHHHHCCCC-CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 78864779873212323311112-45566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSS-DPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~-~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) |+|||+.+-||++|+-..-.... .. .+..-- |..|---.+...+.. -.+.+|=.+...-+ T Consensus 3 vvliGd~~VGKTsli~r~~~~~F~~~----~y~~Ti--------g~~f~~k~i~~~~~~---v~l~iwDtaGqe~~---- 63 (193) T cd04118 3 VVMLGKESVGKTSLVERYVHHRFLVG----PYQNTI--------GAAFVAKRMVVGERV---VTLGIWDTAGSERY---- 63 (193) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCC----CCCCEE--------EEEEEEEEEECCCEE---EEEEEECCCCCHHH---- T ss_conf 89980798328999888752731688----746613--------323588886438757---99998638875357---- Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 0110581012003-343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) ..+.+..++++ .++|+-|-+.+=+| +.|..|+.-++++-. T Consensus 64 --~~l~~~~yr~a~~~ilvydit~~~SF-~~l~~w~~~i~~~~~------------------------------------ 104 (193) T cd04118 64 --EAMSRIYYRGAKAAIVCYDLTDSSSF-ERAKFWVKELQNLEE------------------------------------ 104 (193) T ss_pred --HHHHHHHHCCCCEEEEEEECCCCHHH-HHHHHHHHHHHHCCC------------------------------------ T ss_conf --89898761288738999874881017-899999999862189------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 645321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|-+|+|.+..-+..+....|+. +.++=++|+..|.||.+...|...| T Consensus 105 ------------------~~~iilVGNK~DL~~~~~~~r~V~~ee~-------~~~A~~~~~~~fEtSAktg~nV~el 157 (193) T cd04118 105 ------------------HCKIYLCGTKSDLIEQDRSLRQVDFHDV-------QDFADEIKAQHFETSSKTGQNVDEL 157 (193) T ss_pred ------------------CCEEEEEECCCCHHHCCCCCCCCCHHHH-------HHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ------------------9789998414221120666444688999-------9999966995999962589888899 No 58 >cd04154 Arl2 Arl2 subfamily. Arl2 (Arf-like 2) GTPases are members of the Arf family that bind GDP and GTP with very low affinity. Unlike most Arf family proteins, Arl2 is not myristoylated at its N-terminal helix. The protein PDE-delta, first identified in photoreceptor rod cells, binds specifically to Arl2 and is structurally very similar to RhoGDI. Despite the high structural similarity between Arl2 and Rho proteins and between PDE-delta and RhoGDI, the interactions between the GTPases and their effectors are very different. In its GTP bound form, Arl2 interacts with the protein Binder of Arl2 (BART), and the complex is believed to play a role in mitochondrial adenine nucleotide transport. In its GDP bound form, Arl2 interacts with tubulin- folding Cofactor D; this interaction is believed to play a role in regulation of microtubule dynamics that impact the cytoskeleton, cell division, and cytokinesis. Probab=97.37 E-value=0.0021 Score=39.66 Aligned_columns=152 Identities=17% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .||++|..++|||+|+-.+.........+.. |..+..+...+ ..+++|=+ .|...|.++ T Consensus 16 kIliiG~~~~GKTsil~~l~~~~~~~~~pT~-------------G~~~~~i~~~~-------~~l~iwD~-~Gqe~~r~~ 74 (173) T cd04154 16 RILILGLDNAGKTTILKKLLGEDIDTISPTL-------------GFQIKTLEYEG-------YKLNIWDV-GGQKTLRPY 74 (173) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCEEEEE-------------EEEEEEEEECC-------EEEEEEEC-CCCHHHHHH T ss_conf 8999950898789988887289546034235-------------21688889858-------89999875-875036766 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) -+....-- -.+|+|+|-|++-.+-+....|-.+|++.... T Consensus 75 ~~~y~~~a----~~iI~VvD~sd~~~~~~~~~~l~~ll~~~~~~------------------------------------ 114 (173) T cd04154 75 WRNYFEST----DALIWVVDSSDRLRLDDCKRELKELLQEERLA------------------------------------ 114 (173) T ss_pred HHHHCCCC----CEEEEEEECCCCCCHHHHHHHHHHHHCCHHHC------------------------------------ T ss_conf 55312467----77999975388544688999999874023117------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHH-HHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999-99987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMR-TLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lR-t~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ++|++|+++|+|.-..+..+. |.++++ ..+-.+.-.+|.||.+--..+...+. T Consensus 115 -----------------~~pilI~~NK~Dl~~~~~~~e---------i~~~l~l~~~~~~~~~i~~~SAktGeGI~e~f~ 168 (173) T cd04154 115 -----------------GATLLILANKQDLPGALSEEE---------IREALELDKISSHHWRIQPCSAVTGEGLLQGID 168 (173) T ss_pred -----------------CCEEEEEEECCCCCCCCCHHH---------HHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH T ss_conf -----------------968999972558854579899---------999987786427965899975025888899999 No 59 >cd04120 Rab12 Rab12 subfamily. Rab12 was first identified in canine cells, where it was localized to the Golgi complex. The specific function of Rab12 remains unknown, and inconsistent results about its cellular localization have been reported. More recent studies have identified Rab12 associated with post-Golgi vesicles, or with other small vesicle-like structures but not with the Golgi complex. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic Probab=97.37 E-value=0.0042 Score=37.82 Aligned_columns=150 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+-||++|+.......-.. .+.-.- |..|.--.|.-.+.. -++.+|=- .|.-.| T Consensus 3 IvliGd~~VGKTsli~rf~~~~F~~----~y~~Ti--------g~df~~k~i~i~g~~---i~lqIwDT-aGqE~f---- 62 (202) T cd04120 3 VIIIGSRGVGKTSLMRRFTDDTFCE----ACKSGV--------GVDFKIKTVELRGKK---IRLQIWDT-AGQERF---- 62 (202) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEEECCEE---EEEEEEEC-CCCCHH---- T ss_conf 8998079842899999976381166----656512--------357889999987918---99998756-886035---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+++.-+++. .+|||-|.+.+.+| +.|.+|+..++.+... T Consensus 63 -~~l~~~y~r~a~g~ilVyDit~~~SF-~~l~~W~~~i~~~~~~------------------------------------ 104 (202) T cd04120 63 -NSITSAYYRSAKGIILVYDITKKETF-DDLPKWMKMIDKYASE------------------------------------ 104 (202) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -78877763289879999766984578-9999999999972499------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH-CCEEEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871-841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKH-GASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqY-GAsLiYTS~~~~~nl~~L 284 (523) .+|+++|..|+| |+.++.-..++- +.||-++ |...|.||++...|...+ T Consensus 105 -----------------~~~iiLVGNK~D----L~~~R~Vs~~e~-------~~~A~~~~~~~f~EtSAk~~~NV~e~ 154 (202) T cd04120 105 -----------------DAELLLVGNKLD----CETDREISRQQG-------EKFAQQITGMRFCEASAKDNFNVDEI 154 (202) T ss_pred -----------------CEEEEEEECCCC----HHHHCCCCHHHH-------HHHHHHHCCCEEEEEECCCCCCHHHH T ss_conf -----------------348999712221----210202367999-------99999708970899851489888899 No 60 >cd04143 Rhes_like Rhes_like subfamily. This subfamily includes Rhes (Ras homolog enriched in striatum) and Dexras1/AGS1 (activator of G-protein signaling 1). These proteins are homologous, but exhibit significant differences in tissue distribution and subcellular localization. Rhes is found primarily in the striatum of the brain, but is also expressed in other areas of the brain, such as the cerebral cortex, hippocampus, inferior colliculus, and cerebellum. Rhes expression is controlled by thyroid hormones. In rat PC12 cells, Rhes is farnesylated and localizes to the plasma membrane. Rhes binds and activates PI3K, and plays a role in coupling serpentine membrane receptors with heterotrimeric G-protein signaling. Rhes has recently been shown to be reduced under conditions of dopamine supersensitivity and may play a role in determining dopamine receptor sensitivity. Dexras1/AGS1 is a dexamethasone-induced Ras protein that is expressed primarily in the brain, with low expression l Probab=97.37 E-value=0.0049 Score=37.38 Aligned_columns=170 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |++||..+-||++|+..+....-.. .+.- -++-.|.-...-|-+. ..+.+|=-+.-+.+ T Consensus 3 IVllGd~~VGKTSLi~Rf~~~~F~e----~y~p----------TI~df~~K~i~idg~~--v~L~IwDTAGqE~f----- 61 (247) T cd04143 3 MVVLGASKVGKTAIVSRFLGGRFEE----QYTP----------TIEDFHRKLYSIRGEV--YQLDILDTSGNHPF----- 61 (247) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCC----------CCCCEEEEEEEECCEE--EEEEEECCCCCCCC----- T ss_conf 8998269831888988765383267----6234----------2100057899887928--99997225446545----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..+.+. .++||-|.+.+.+| +.++.|...++++...+....+ T Consensus 62 -~sl~~~~~~~ad~~ILVyDIT~r~SF-e~v~~w~~eI~e~k~~~~~~~~------------------------------ 109 (247) T cd04143 62 -PAMRRLSILTGDVFILVFSLDNRESF-EEVCRLREQILETKSCLKNKTK------------------------------ 109 (247) T ss_pred -CCCCCCCCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHHHHHCCCCC------------------------------ T ss_conf -54340210388789999756997899-9999999999986311002345------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .|-.+|+++|-.|||. ...|.=..+-..||..+ ++|+..|-||+|...|.+.+-+. T Consensus 110 --------------~~~~vpiILVGNK~DL-------~~~R~Vs~eEa~q~~A~---~~~~~ffEtSAKtg~NVdE~F~~ 165 (247) T cd04143 110 --------------ENVKIPMVICGNKADR-------DFPREVQRDEVEQLVGG---DENCAYFEVSAKKNSNLDEMFRA 165 (247) T ss_pred --------------CCCCCEEEEEECCCCC-------CCCCCCCHHHHHHHHHH---HCCCCEEEEECCCCCCHHHHHHH T ss_conf --------------7887279997055673-------22573388999999998---27982899852589888999999 Q ss_pred HCCCCCCC Q ss_conf 22532246 Q Fun_An_XP_0013 288 SLGIHSLL 295 (523) Q Consensus 288 ~lgih~ll 295 (523) .+..-.|+ T Consensus 166 L~~~~~l~ 173 (247) T cd04143 166 LFSLAKLP 173 (247) T ss_pred HHHHCCCC T ss_conf 99864873 No 61 >cd04107 Rab32_Rab38 Rab38/Rab32 subfamily. Rab32 and Rab38 are members of the Rab family of small GTPases. Human Rab32 was first identified in platelets but it is expressed in a variety of cell types, where it functions as an A-kinase anchoring protein (AKAP). Rab38 has been shown to be melanocyte-specific. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=97.35 E-value=0.0076 Score=36.22 Aligned_columns=156 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+-||++|+..+-...-.. .+.--- |.+|..-.+.-++-.. .++.+|=. -|.-.|..|. T Consensus 3 IvliGd~~VGKTsli~r~~~~~F~~----~~~~Ti--------g~d~~~k~i~~~~~~~--v~l~iwDt-aGqe~f~~l~ 67 (201) T cd04107 3 VLVIGDLGVGKTSIIKRYVHGIFSQ----HYKATI--------GVDFALKVIEWDPNTV--VRLQLWDI-AGQERFGGMT 67 (201) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCEE--------EEEEEEEEEEECCCEE--EEEEEECC-CCCHHHHHHH T ss_conf 8998169954899999977180067----656503--------4467788998769768--99986227-8842455665 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +....--. .++|+-|.+.+=+| +.|..|..-|+.-+..-..+ T Consensus 68 ~~y~r~a~----~~ilvyDit~~~SF-~~i~~W~~~i~~~~~~~~~~--------------------------------- 109 (201) T cd04107 68 RVYYRGAV----GAIIVFDVTRPSTF-EAVLKWKADLDSKVTLPNGE--------------------------------- 109 (201) T ss_pred HHHCCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHHHHCCCCC--------------------------------- T ss_conf 65427987----69999873897789-99999999999874036899--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC-CEEEEECCCCCCCHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718-41255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHG-ASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYG-AsLiYTS~~~~~nl~~L 284 (523) -+|+++|-.|+| |++++--..|+ ...||-++| ...|.||++...|...+ T Consensus 110 ----------------~ipiilVGNK~D----L~~~~~v~~~e-------~~~~a~~~~~~~~fEtSAktg~nV~e~ 159 (201) T cd04107 110 ----------------PIPCLLLANKCD----LKKRLAKDGEQ-------MDQFCKENGFIGWFETSAKEGINIEEA 159 (201) T ss_pred ----------------CCEEEEEECCCC----CHHHCCCCHHH-------HHHHHHHCCCCCEEEEECCCCCCHHHH T ss_conf ----------------728999705887----30004479899-------999999639982688750489787899 No 62 >smart00173 RAS Ras subfamily of RAS small GTPases; Similar in fold and function to the bacterial EF-Tu GTPase. p21Ras couples receptor Tyr kinases and G protein receptors to protein kinase cascades Probab=97.35 E-value=0.0025 Score=39.15 Aligned_columns=151 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+...+-.. ++.- -++-.|.-...-+... ..+.+|=. .|...|..+. T Consensus 5 iiliGd~~vGKTsli~r~~~~~f~~----~y~~----------ti~~~~~k~~~i~~~~--~~l~iwDt-aG~e~~~~~~ 67 (166) T smart00173 5 LVVLGSGGVGKSALTIQFVQGIFVD----DYDP----------TIEDSYRKQIEIDGEV--CLLDILDT-AGQEEFSAMR 67 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CCCCCEEEEEEECCEE--EEEEEEEC-CCCCCHHHHH T ss_conf 9998079964899999987280277----5455----------2121225789898979--99998627-9985123677 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--+ .|||+-|.+++.+|-. +++|..-+.+...+- T Consensus 68 ~~~~~~a~----~~iivydit~~~Sf~~-~~~w~~~i~~~~~~~------------------------------------ 106 (166) T smart00173 68 DQYMRTGE----GFLLVYSITDRQSFEE-IKKFREQILRVKDRD------------------------------------ 106 (166) T ss_pred HHHHCCCC----CEEEEEECCCHHHHHH-HHHHHHHHHHHCCCC------------------------------------ T ss_conf 88740799----3599997499789999-989989998742899------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|++|+|. +++-..-.+-.+.+|=++|+..|.||.+...|...+ T Consensus 107 ----------------~ip~vlvgNK~Dl-----------~~~r~v~~~~~~~~a~~~~~~~~E~SAk~~~nV~e~ 155 (166) T smart00173 107 ----------------DVPIVLVGNKCDL-----------ENERQVSTEEGKELARQWNCPFLETSAKERINVDEA 155 (166) T ss_pred ----------------CCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------9579998114651-----------000457678999999966996999972589888899 No 63 >cd04134 Rho3 Rho3 subfamily. Rho3 is a member of the Rho family found only in fungi. Rho3 is believed to regulate cell polarity by interacting with the diaphanous/formin family protein For3 to control both the actin cytoskeleton and microtubules. Rho3 is also believed to have a direct role in exocytosis that is independent of its role in regulating actin polarity. The function in exocytosis may be two-pronged: first, in the transport of post-Golgi vesicles from the mother cell to the bud, mediated by myosin (Myo2); second, in the docking and fusion of vesicles to the plasma membrane, mediated by an exocyst (Exo70) protein. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Probab=97.34 E-value=0.0017 Score=40.22 Aligned_columns=162 Identities=17% Q ss_pred EEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHH Q ss_conf 04788647798732123233111124556631225656744443342022331000677455110167871788711232 Q Fun_An_XP_0013 47 KNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAP 126 (523) Q Consensus 47 KnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~ 126 (523) |-|+++|+.+-||++|+-... +|.++.--+.-. +-.| +.....++...++.+|=- .|.-.| T Consensus 1 ~KiiliGd~~VGKTsLi~rf~-------------~~~F~~~~~~Ti-~~~~--~~~i~vd~~~v~l~iwDT-aGqE~f-- 61 (189) T cd04134 1 RKVVVLGDGACGKTSLLNVFT-------------RGYFPQVYEPTV-FENY--VHDIFVDGLHIELSLWDT-AGQEEF-- 61 (189) T ss_pred CEEEEEECCCCCHHHHHHHHH-------------CCCCCCCCCCEE-EEEE--EEEEEECCEEEEEEEECC-CCCHHH-- T ss_conf 968998269833899998876-------------380067516616-7756--786677794899998627-787145-- Q ss_pred HHHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC Q ss_conf 00110581012003-34333000031368999999999999998506958889999999998622688767777767777 Q Fun_An_XP_0013 127 LLKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFT 205 (523) Q Consensus 127 LLk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~ 205 (523) ..+.+..+++. .++|+-|.+.+.+|-.-..+|+.-++++. + T Consensus 62 ---~~l~~~~y~~a~~~ilvydit~~~Sf~~i~~~W~~ei~~~~-----~------------------------------ 103 (189) T cd04134 62 ---DRLRSLSYADTDVIMLCFSVDSPDSLENVESKWLGEIREHC-----P------------------------------ 103 (189) T ss_pred ---HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHC-----C------------------------------ T ss_conf ---77888773389878999866884466899998899999835-----8------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHH-HHHHHHHHCC-EEEEECCCCCCCHHH Q ss_conf 66453213688875326789507999618755678886358855689999999-9999987184-125521233210345 Q Fun_An_XP_0013 206 SSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQF-MRTLLLKHGA-SLIYTTPFLANSLQS 283 (523) Q Consensus 206 ~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~-lRt~cLqYGA-sLiYTS~~~~~nl~~ 283 (523) ++|+++|-+|||..+.-+....-..+.-..|... -..++-++|| ..|.||+|...|... T Consensus 104 -------------------~v~iiLVGnK~DL~~~~~~~~~~~~~~~~~vs~~e~~~~a~~~~~~~y~EtSAKt~~nV~e 164 (189) T cd04134 104 -------------------GVKLVLVALKCDLREARNERDDLQRYGKHTISYEEGLAVAKRINALRYLECSAKLNRGVNE 164 (189) T ss_pred -------------------CCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHH T ss_conf -------------------9559998504676553134566765313677989999999980895068864257878789 Q ss_pred H Q ss_conf 6 Q Fun_An_XP_0013 284 L 284 (523) Q Consensus 284 L 284 (523) + T Consensus 165 ~ 165 (189) T cd04134 165 A 165 (189) T ss_pred H T ss_conf 9 No 64 >cd04144 Ras2 Ras2 subfamily. The Ras2 subfamily, found exclusively in fungi, was first identified in Ustilago maydis. In U. maydis, Ras2 is regulated by Sql2, a protein that is homologous to GEFs (guanine nucleotide exchange factors) of the CDC25 family. Ras2 has been shown to induce filamentous growth, but the signaling cascade through which Ras2 and Sql2 regulate cell morphology is not known. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Probab=97.33 E-value=0.0042 Score=37.79 Aligned_columns=154 Identities=16% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+-||++|+......+-...- .|-|+..|.-.+ ..++....+.+|=-+..+-+ T Consensus 2 ivliGd~gVGKTsLi~rf~~~~F~~~y--------~pTi~~~~~~~~--------~i~~~~~~l~iwDTaGqe~~----- 60 (190) T cd04144 2 LVVLGDGGVGKTALTIQLCLNHFVETY--------DPTIEDSYRKQV--------VVDGQPCMLEVLDTAGQEEY----- 60 (190) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCC--------CCCCEEEEEEEE--------EECCEEEEEEEEECCCCCHH----- T ss_conf 788817984289999998708107764--------664011147889--------87154799999747986024----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) -.+.+..++++ .+||+-|.+.+-+|-. |..|...+.++....... T Consensus 61 -~~l~~~~~r~a~~~ilVyditd~~SF~~-i~~w~~~i~~~~~~~~~~-------------------------------- 106 (190) T cd04144 61 -TALRDQWIREGEGFILVYSITSRSTFER-VERFREQIQRVKDESAAD-------------------------------- 106 (190) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHHHH-HHHHHHHHHHHHHHCCCC-------------------------------- T ss_conf -6887875305607899987599778999-999999999874206999-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) +|+++|.+|+| |..++.-..|+ .+.+|-++|+..|.||++...|...+.+ T Consensus 107 ------------------~piilVGNK~D----L~~~r~V~~ee-------~~~~a~~~~~~y~E~SAk~~~nV~e~F~ 156 (190) T cd04144 107 ------------------VPIMIVGNKCD----KVYEREVSTEE-------GAALARRLGCEFIEASAKTNVNVERAFY 156 (190) T ss_pred ------------------CEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf ------------------78999705653----33446679899-------9999996699199986158988789999 No 65 >cd04149 Arf6 Arf6 subfamily. Arf6 (ADP ribosylation factor 6) proteins localize to the plasma membrane, where they perform a wide variety of functions. In its active, GTP-bound form, Arf6 is involved in cell spreading, Rac-induced formation of plasma membrane ruffles, cell migration, wound healing, and Fc-mediated phagocytosis. Arf6 appears to change the actin structure at the plasma membrane by activating Rac, a Rho family protein involved in membrane ruffling. Arf6 is required for and enhances Rac formation of ruffles. Arf6 can regulate dendritic branching in hippocampal neurons, and in yeast it localizes to the growing bud, where it plays a role in polarized growth and bud site selection. In leukocytes, Arf6 is required for chemokine-stimulated migration across endothelial cells. Arf6 also plays a role in down-regulation of beta2-adrenergic receptors and luteinizing hormone receptors by facilitating the release of sequestered arrestin to allow endocytosis. Arf6 is believed t Probab=97.32 E-value=0.0013 Score=41.01 Aligned_columns=153 Identities=16% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .||++|-+.+||||+|..+.......+.|.. |..+..++..+ .++.+|-+ .|.-.+.++ T Consensus 11 kililGl~~sGKTtil~~l~~~~~~~~~pTv-------------g~~~~~~~~~~-------~~l~iwD~-~Gqe~~r~l 69 (168) T cd04149 11 RILMLGLDAAGKTTILYKLKLGQSVTTIPTV-------------GFNVETVTYKN-------VKFNVWDV-GGQDKIRPL 69 (168) T ss_pred EEEEEEECCCCHHHHHHHHHCCCCCEEEEEE-------------EEEEEEEEECC-------EEEEEEEC-CCCHHHHHH T ss_conf 8999850898788988776438610243001-------------24788987447-------28999872-871356776 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+....--.. +|+|+|-|+. ++|..+...|...+..-... T Consensus 70 w~~Yy~~a~~----iifVvD~sd~----~~l~~~~~~l~~~l~~~~~~-------------------------------- 109 (168) T cd04149 70 WRHYYTGTQG----LIFVVDSADR----DRIDEARQELHRIINDREMR-------------------------------- 109 (168) T ss_pred HHHHCCCCCE----EEEEEECCCC----CCHHHHHHHHHHHHCCCCCC-------------------------------- T ss_conf 5865068877----9999825773----22788999999985131327-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ++|++|++.|+|.-..+.-+.==..-.+++++ .+.-.++.||++.-..+..-+. T Consensus 110 -----------------~~pili~~NK~Dl~~~~~~~ei~~~l~l~~~~--------~~~~~i~~~SA~tG~Gi~e~~~ 163 (168) T cd04149 110 -----------------DALLLVFANKQDLPDAMKPHEIQEKLGLTRIR--------DRNWYVQPSCATSGDGLYEGLT 163 (168) T ss_pred -----------------CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHC--------CCCEEEEEEECCCCCCHHHHHH T ss_conf -----------------97899996156886577989999886468751--------6965899851456888799999 No 66 >smart00177 ARF ARF-like small GTPases; ARF, ADP-ribosylation factor; Ras homologues involved in vesicular transport. Activator of phospholipase D isoforms. Unlike Ras proteins they lack cysteine residues at their C-termini and therefore are unlikely to be prenylated. ARFs are N-terminally myristoylated. Contains ATP/GTP-binding motif (P-loop). Probab=97.31 E-value=0.0012 Score=41.18 Aligned_columns=152 Identities=15% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .||++|...+||||||..+.......+.|.. |..+..++..+ .++.+|=+ .|.-.+ T Consensus 19 kiviiG~~~~GKTtil~~l~~~~~~~~~pTv-------------g~~~~~i~~~~-------~~l~iwD~-~Gqe~~--- 74 (181) T smart00177 19 RILMVGLDAAGKTTILYKLKLGESVTTIPTI-------------GFNVETVTYKN-------ISFTVWDV-GGQDKI--- 74 (181) T ss_pred EEEEEEECCCCHHHHHHHHHCCCCCEEEEEE-------------CCCEEEEEECC-------EEEEEEEC-CCCHHH--- T ss_conf 8999851898789999987528733022000-------------01035664143-------59999874-873457--- Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 0110581012003-343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) -.+.+.-++++ .+|+|+|-|+.-.+-+....|..+|.+. T Consensus 75 --r~lw~~Yy~~a~~iI~VvD~sd~~~~~~~~~~l~~~l~~~-------------------------------------- 114 (181) T smart00177 75 --RPLWRHYYTNTQGLIFVVDSNDRDRIDEAREELHRMLNED-------------------------------------- 114 (181) T ss_pred --HHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCC-------------------------------------- T ss_conf --8888876068968999986588334899999999985020-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 64532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ..-++|++|++.|+|.-+.+..+.--.+...+.++. ..-.++.||++.-..++..+. T Consensus 115 ---------------~~~~~pilIl~NK~Dl~~~~~~~ei~~~l~l~~~~~--------~~~~i~~~SA~tG~GI~e~f~ 171 (181) T smart00177 115 ---------------ELRDAVILVFANKQDLPDAMKAAEITEKLGLHSIRD--------RNWYIQPTCATSGDGLYEGLT 171 (181) T ss_pred ---------------CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCC--------CCEEEEEEECCCCCCHHHHHH T ss_conf ---------------227978999950558302179999998863676426--------975899862456888899999 No 67 >cd04153 Arl5_Arl8 Arl5/Arl8 subfamily. Arl5 (Arf-like 5) and Arl8, like Arl4 and Arl7, are localized to the nucleus and nucleolus. Arl5 is developmentally regulated during embryogenesis in mice. Human Arl5 interacts with the heterochromatin protein 1-alpha (HP1alpha), a nonhistone chromosomal protein that is associated with heterochromatin and telomeres, and prevents telomere fusion. Arl5 may also play a role in embryonic nuclear dynamics and/or signaling cascades. Arl8 was identified from a fetal cartilage cDNA library. It is found in brain, heart, lung, cartilage, and kidney. No function has been assigned for Arl8 to date. Probab=97.30 E-value=0.00099 Score=41.66 Aligned_columns=152 Identities=14% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .||++|..++|||+++..+.........|.- |..+..+++.+ .++.+|=+ .|.-.+ T Consensus 17 kililG~~~sGKTtil~~~~~~~~~~~~pTv-------------g~~~~~i~~~~-------~~~~iwD~-~Gqe~~--- 72 (174) T cd04153 17 KVIIVGLDNAGKTTILYQFLLGEVVHTSPTI-------------GSNVEEIVYKN-------IRFLMWDI-GGQESL--- 72 (174) T ss_pred EEEEEEECCCCHHHHHHHHHCCCCCCEECCC-------------CCEEEEEEECC-------EEEEEEEC-CCCCCC--- T ss_conf 8999850898689988887538603200210-------------00588987285-------89999876-886234--- Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 0110581012003-343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) -.+.+.-++++ .+|+|+|-|++=.+-+....|..+|.+.-.+ T Consensus 73 --r~~w~~y~~~~~~iI~VvD~sd~~~~~~~~~~l~~~l~~~~~~----------------------------------- 115 (174) T cd04153 73 --RSSWNTYYTNTDAVILVIDSTDRERLPLTKEELYKMLAHEDLR----------------------------------- 115 (174) T ss_pred --CHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCC----------------------------------- T ss_conf --0466754058887999996688200788999999985252427----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 64532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ++|++|++.|+|.-..+..++=-..-..+.+.+ +.-.++.||++--..++..+. T Consensus 116 ------------------~~piLIlaNK~Dl~~~~~~~ei~~~l~l~~~~~--------~~~~i~~~SA~tg~Gi~e~~~ 169 (174) T cd04153 116 ------------------KAVLLVLANKQDLKGAMTPAEISESLGLTSIRD--------HTWHIQGCCALTGEGLPEGLD 169 (174) T ss_pred ------------------CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHC--------CCEEEEEEECCCCCCHHHHHH T ss_conf ------------------978999960668876789899998975676614--------975899875025888899999 No 68 >cd04158 ARD1 ARD1 subfamily. ARD1 (ADP-ribosylation factor domain protein 1) is an unusual member of the Arf family. In addition to the C-terminal Arf domain, ARD1 has an additional 46-kDa N-terminal domain that contains a RING finger domain, two predicted B-Boxes, and a coiled-coil protein interaction motif. This domain belongs to the TRIM (tripartite motif) or RBCC (RING, B-Box, coiled-coil) family. Like most Arfs, the ARD1 Arf domain lacks detectable GTPase activity. However, unlike most Arfs, the full-length ARD1 protein has significant GTPase activity due to the GAP (GTPase-activating protein) activity exhibited by the 46-kDa N-terminal domain. The GAP domain of ARD1 is specific for its own Arf domain and does not bind other Arfs. The rate of GDP dissociation from the ARD1 Arf domain is slowed by the adjacent 15 amino acids, which act as a GDI (GDP-dissociation inhibitor) domain. ARD1 is ubiquitously expressed in cells and localizes to the Golgi and to the lysosomal membra Probab=97.27 E-value=0.0049 Score=37.36 Aligned_columns=152 Identities=18% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) ||++|-+++||||+|..+...+.....|.. |.....+++.+ .++.+|=+ .|...+ T Consensus 2 IliiGl~~aGKTtil~~l~~~~~~~~~pTv-------------G~~~~~i~~~~-------~~l~iwD~-gG~~~~---- 56 (169) T cd04158 2 VVTLGLDGAGKTTILFKLKQDEFMQPIPTI-------------GFNVETVEYKN-------LKFTIWDV-GGKHKL---- 56 (169) T ss_pred EEEEEECCCCHHHHHHHHHCCCCCCEEEEE-------------CEEEEEEEECC-------EEEEEEEC-CCCCHH---- T ss_conf 889962798689988888558314312101-------------20688887457-------49999873-887402---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+.-++++ -+|+|+|-|+.=.+-+....+..+|.+ T Consensus 57 -r~~w~~Yy~~~~giIfVvDssd~~~~~e~~~~l~~ll~~---------------------------------------- 95 (169) T cd04158 57 -RPLWKHYYLNTQAVVFVVDSSHRDRVSEAHSELAKLLTE---------------------------------------- 95 (169) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHCC---------------------------------------- T ss_conf -577887504766899999655633589999999998445---------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+.-++|++|++.|+|. ..--..++.--.++ |+++|-..--.++.||++--..+...+. T Consensus 96 -------------~~~~~~piLi~aNK~Dl------~~~~~~~ei~~~l~-l~~~~~~r~~~i~~~SA~tG~Gi~E~f~ 154 (169) T cd04158 96 -------------KELRDALLLIFANKQDV------AGALSVEEMTELLS-LHKLCCGRSWYIQGCDARSGMGLYEGLD 154 (169) T ss_pred -------------CCCCCCEEEEEECCCCC------CCCCCHHHHHHHHH-HHHHHCCCCEEEEEEECCCCCCHHHHHH T ss_conf -------------10169569998515588------76889899998963-6877338956999752346888789999 No 69 >cd01889 SelB_euk SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of SelB recognizes this hairpin, while the N-terminal part binds GTP and tRNA in analogy with elongation factor Tu (EF-Tu). It specifically recognizes the selenocysteine charged tRNAsec, which has a UCA anticodon, in an EF-Tu like manner. This allows insertion of selenocysteine at in-frame UGA stop codons. In E. coli SelB binds GTP, selenocysteyl-tRNAsec and a stem-loop structure immediately downstream of the UGA codon (the SECIS sequence). The absence of active SelB prevents the participation of selenocysteyl-tRNAsec in translation. Archaeal and animal mechanisms of selenocysteine incorporation are more complex. Although the SECIS elements have different secondary structures and conserved elements between archaea and euk Probab=97.27 E-value=0.0021 Score=39.68 Aligned_columns=167 Identities=17% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCC---CCCCCCCCCCCCCCCCCCCCCCEEEEEEEECC-----CCCCCCEEEEEEECC Q ss_conf 4788647798732123233111124---55663122565674444334202233100067-----745511016787178 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSD---PSLSNDKRKGRVPPVANQFALGYTYQDVLDAD-----HEDTLARVSAYLLSE 119 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~---~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D-----~eD~~aR~svyiL~d 119 (523) ||-++|---+||+||++.|++..+. -+...|+.+| +.. -|||.++.+.-.+ ......+.-+-++ T Consensus 2 Ni~iiGHVDhGKTTL~~~L~~~~~~~~~D~~~~E~eRG-ITi-----~lg~~~f~~~~~~~~~~~~~~~~~~~~i~~I-- 73 (192) T cd01889 2 NVGVLGHVDSGKTSLAKALSEIASTAAFDKNPQSQERG-ITL-----DLGFSSFYVDKPKHLRELINPGEENLQITLV-- 73 (192) T ss_pred EEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHCC-CEE-----EECCEEEEECCHHHHCCCCCCCCCCEEEEEE-- T ss_conf 18899863078779999987543221104534677658-402-----4210113411101000012457664279997-- Q ss_pred CCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCC Q ss_conf 87112320011058101200334333000031368999999999999998506958889999999998622688767777 Q Fun_An_XP_0013 120 PSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSG 199 (523) Q Consensus 120 ~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~ 199 (523) -.|.|...++-.+..-+..+-.++++---.- ++.|-++-+.+++. T Consensus 74 DtPGH~dF~~~m~~G~~~~D~aiLvV~a~~G---v~~QT~eh~~~~~~-------------------------------- 118 (192) T cd01889 74 DCPGHASLIRTIIGGAQIIDLMLLVVDATKG---IQTQTAECLVIGEI-------------------------------- 118 (192) T ss_pred ECCCHHHHHHHHHHHHHHHCEEEEEEECCCC---CCCCHHHHHHHHHH-------------------------------- T ss_conf 5566688999999998763406888845788---57446899999997-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCE---EEEECCC Q ss_conf 7677776645321368887532678950799961875567888635885568999999999999871841---2552123 Q Fun_An_XP_0013 200 GAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGAS---LIYTTPF 276 (523) Q Consensus 200 ~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAs---LiYTS~~ 276 (523) +|+|++||++|.|.+.. .|+++.|+.|.+.|..+.-+.|.. .|..|.+ T Consensus 119 ------------------------~~~~~iv~iNKiD~v~~-----~~~~~~~~~ik~~i~~~l~~~~~~~~~iipiSA~ 169 (192) T cd01889 119 ------------------------LCKKLIVVLNKIDLIPE-----EERERKIEKMKKKLQKTLEKTRFKNSPIIPVSAK 169 (192) T ss_pred ------------------------CCCCEEEEEEECCCCCC-----CHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC T ss_conf ------------------------28977999973278994-----0457899999999998851137887126870377 Q ss_pred CCCCHHHHHH Q ss_conf 3210345655 Q Fun_An_XP_0013 277 LANSLQSLIH 286 (523) Q Consensus 277 ~~~nl~~Llh 286 (523) .-.+...|.. T Consensus 170 tG~gI~eL~~ 179 (192) T cd01889 170 PGGGEAELGK 179 (192) T ss_pred CCCCHHHHHH T ss_conf 8998799999 No 70 >cd04172 Rnd3_RhoE_Rho8 Rnd3/RhoE/Rho8 subfamily. Rnd3/RhoE/Rho8 is a member of the novel Rho subfamily Rnd, together with Rnd1/Rho6 and Rnd2/Rho7. Rnd3/RhoE is known to bind the serine-threonine kinase ROCK I. Unphosphorylated Rnd3/RhoE associates primarily with membranes, but ROCK I-phosphorylated Rnd3/RhoE localizes in the cytosol. Phosphorylation of Rnd3/RhoE correlates with its activity in disrupting RhoA-induced stress fibers and inhibiting Ras-induced fibroblast transformation. In cells that lack stress fibers, such as macrophages and monocytes, Rnd3/RhoE induces a redistribution of actin, causing morphological changes in the cell. In addition, Rnd3/RhoE has been shown to inhibit cell cycle progression in G1 phase at a point upstream of the pRb family pocket protein checkpoint. Rnd3/RhoE has also been shown to inhibit Ras- and Raf-induced fibroblast transformation. In mammary epithelial tumor cells, Rnd3/RhoE regulates the assembly of the apical junction complex and tight Probab=97.25 E-value=0.0016 Score=40.41 Aligned_columns=162 Identities=20% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+...+-...- .|.|...|...+ ..++..-++.+|=- .|...| T Consensus 8 ivlvGd~~VGKTsli~r~~~~~F~~~~--------~~Ti~~~~~~~~--------~i~~~~v~l~iwDT-aGqe~~---- 66 (182) T cd04172 8 IVVVGDSQCGKTALLHVFAKDCFPENY--------VPTVFENYTASF--------EIDTQRIELSLWDT-SGSPYY---- 66 (182) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCC--------CCEEEEEEEEEE--------EECCEEEEEEEECC-CCCHHH---- T ss_conf 999836985488998887538015761--------205775368999--------88785999998507-887456---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) -.+.+..++++ .++|+-|.+++-+|-.=+.+|..-+|++.. T Consensus 67 -~~l~~~~y~~a~~~ilvfdit~~~Sf~~v~~~W~~ei~~~~~------------------------------------- 108 (182) T cd04172 67 -DNVRPLSYPDSDAVLICFDISRPETLDSVLKKWKGEIQEFCP------------------------------------- 108 (182) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCC------------------------------------- T ss_conf -666476526998799998658855789999998999998468------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHH-HHHHHHHHCCE-EEEECCCCCCC-HHHH Q ss_conf 453213688875326789507999618755678886358855689999999-99999871841-25521233210-3456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQF-MRTLLLKHGAS-LIYTTPFLANS-LQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~-lRt~cLqYGAs-LiYTS~~~~~n-l~~L 284 (523) .+|+++|-+|+|.-+-.+---+..++.-..|..- -..++-++||. -|=||.+...| .+.+ T Consensus 109 -----------------~~~iiLVGnK~DL~~~~~~~~~l~~~~q~~Vs~eeg~~~A~~~~a~~y~EtSAk~~~n~v~~~ 171 (182) T cd04172 109 -----------------NTKMLLVGCKSDLRTDLTTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDI 171 (182) T ss_pred -----------------CCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHH T ss_conf -----------------966999854876532057787676346876798999999997189506887512688418999 Q ss_pred HH Q ss_conf 55 Q Fun_An_XP_0013 285 IH 286 (523) Q Consensus 285 lh 286 (523) -| T Consensus 172 F~ 173 (182) T cd04172 172 FH 173 (182) T ss_pred HH T ss_conf 99 No 71 >cd00881 GTP_translation_factor GTP translation factor family. This family consists primarily of translation initiation, elongation, and release factors, which play specific roles in protein translation. In addition, the family includes Snu114p, a component of the U5 small nuclear riboprotein particle which is a component of the spliceosome and is involved in excision of introns, TetM, a tetracycline resistance gene that protects the ribosome from tetracycline binding, and the unusual subfamily CysN/ATPS, which has an unrelated function (ATP sulfurylase) acquired through lateral transfer of the EF1-alpha gene and development of a new function. Probab=97.16 E-value=0.0036 Score=38.18 Aligned_columns=153 Identities=20% Q ss_pred EEEEECCCCCCCEEHHHHHHCC------------CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEE Q ss_conf 4788647798732123233111------------1245566312256567444433420223310006774551101678 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAAD------------SSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAY 115 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~------------~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svy 115 (523) ||-++|--.+||+||++.|-.. ...-..+.|+.+|. ...++|.++...+ -.+ T Consensus 1 Ni~iiGhvd~GKTTL~~~ll~~~~~~~~~~~~~~~~~D~~~~E~~rgi------ti~~~~~~~~~~~----------~~~ 64 (189) T cd00881 1 NVGIAGHVDHGKTTLTERLLYVTGDIERDGTVEETFLDVLKEERERGI------TIKSGVATFEWPD----------RRV 64 (189) T ss_pred CEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHH------HHCEEEEEEECCC----------EEE T ss_conf 958897348887899999998740233430001000055478888654------3101236873188----------189 Q ss_pred EECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC Q ss_conf 71788711232001105810120033433300003136899999999999999850695888999999999862268876 Q Fun_An_XP_0013 116 LLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMD 195 (523) Q Consensus 116 iL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~ 195 (523) .+ =-.|.|..+.+-....-..-+..++++ |-.+..+... ++.++.+.. T Consensus 65 ~~-iDtPGH~~f~~~~~~~~~~~D~~ilvV-da~~G~~~qt--------------------~~~~~~~~~---------- 112 (189) T cd00881 65 NF-IDTPGHEDFSSEVIRGLSVSDGAILVV-DANEGVQPQT--------------------REHLRIARE---------- 112 (189) T ss_pred EE-EECCCCHHHHHHHHHHCCCCCEEEEEE-CCCCCCCHHH--------------------HHHHHHHHH---------- T ss_conf 99-817874556776632000046689998-1777644147--------------------999999996---------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEE----- Q ss_conf 777776777766453213688875326789507999618755678886358855689999999999998718412----- Q Fun_An_XP_0013 196 SSSGGAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASL----- 270 (523) Q Consensus 196 ~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsL----- 270 (523) .++|+++|++|.|.+ .+|.|+.+.+-++.+.-+||... T Consensus 113 ----------------------------~~~~~iiviNKiD~~---------~~~~~~~v~~ei~~~l~~~~~~~~~~~~ 155 (189) T cd00881 113 ----------------------------GGLPIIVAINKIDRV---------GEEDLEEVLREIKELLGLIGFISTKEEG 155 (189) T ss_pred ----------------------------CCCCEEEEEECCCCC---------CCCCHHHHHHHHHHHHHHHCCCCHHHHH T ss_conf ----------------------------589689998546888---------8303899999999998641333002332 Q ss_pred ---------EEECCCCCCCHHHHH Q ss_conf ---------552123321034565 Q Fun_An_XP_0013 271 ---------IYTTPFLANSLQSLI 285 (523) Q Consensus 271 ---------iYTS~~~~~nl~~Ll 285 (523) +++|.+...+...|+ T Consensus 156 ~~~~~~~piv~~SA~~G~gi~~Ll 179 (189) T cd00881 156 TRNGLLVPIVPGSALTGIGVEELL 179 (189) T ss_pred HCCCCCEEEEEEECCCCCCHHHHH T ss_conf 036774217983144689868999 No 72 >cd04105 SR_beta Signal recognition particle receptor, beta subunit (SR-beta). SR-beta and SR-alpha form the heterodimeric signal recognition particle (SRP or SR) receptor that binds SRP to regulate protein translocation across the ER membrane. Nascent polypeptide chains are synthesized with an N-terminal hydrophobic signal sequence that binds SRP54, a component of the SRP. SRP directs targeting of the ribosome-nascent chain complex (RNC) to the ER membrane via interaction with the SR, which is localized to the ER membrane. The RNC is then transferred to the protein-conducting channel, or translocon, which facilitates polypeptide translation across the ER membrane or integration into the ER membrane. SR-beta is found only in eukaryotes; it is believed to control the release of the signal sequence from SRP54 upon binding of the ribosome to the translocon. High expression of SR-beta has been observed in human colon cancer, suggesting it may play a role in the development of this typ Probab=97.10 E-value=0.0047 Score=37.49 Aligned_columns=127 Identities=18% Q ss_pred EEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHH Q ss_conf 04788647798732123233111124556631225656744443342022331000677455110167871788711232 Q Fun_An_XP_0013 47 KNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAP 126 (523) Q Consensus 47 KnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~ 126 (523) .+||++|=+++|||+||..|...+...+.+.- .+-.++.+..+.... .+..+|=+ -|...+.. T Consensus 1 ~~vLllGl~~AGKTtll~~L~~~~~~~T~tSi-----------~pn~~~~~~~~~~~~-----~~~~v~D~-pGh~klR~ 63 (203) T cd04105 1 PTVLLLGPSDSGKTALFTKLTTGKYRSTVTSI-----------EPNVATFILNSEGKG-----KKFRLVDV-PGHPKLRD 63 (203) T ss_pred CEEEEEECCCCCHHHHHHHHHCCCCCCCCCCC-----------CCCEEEEEEEECCCC-----EEEEEEEE-CCCHHHHH T ss_conf 95899823997289999987618824420455-----------652578986302487-----58999870-89467779 Q ss_pred -HHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC Q ss_conf -0011058101200334333000031368999999999999998506958889999999998622688767777767777 Q Fun_An_XP_0013 127 -LLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFT 205 (523) Q Consensus 127 -LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~ 205 (523) |.+..... ---||+|+|=+.-- +.++.=+..|-+++-.+..-.. T Consensus 64 ~l~~~~~~~----~~gIIfVVDSsd~~---~~~~~~ae~Ly~iL~~~~~~~~---------------------------- 108 (203) T cd04105 64 KLLETLKNS----AKGIVFVVDSATFQ---KNLKDVAEFLYDILTDLEKVKN---------------------------- 108 (203) T ss_pred HHHHHHHHH----CCEEEEEEECCCCH---HHHHHHHHHHHHHHHHHHHCCC---------------------------- T ss_conf 999975200----77899998556653---4599999999998742010157---------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHH---------HHHHH Q ss_conf 6645321368887532678950799961875567---------88863 Q Fun_An_XP_0013 206 SSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIE---------KLEKD 244 (523) Q Consensus 206 ~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~---------~LEKe 244 (523) +|||+|+|.|.|.-. .|||| T Consensus 109 -------------------~iPvLI~~NKqDl~tA~~~~~ik~~LEkE 137 (203) T cd04105 109 -------------------KIPVLIACNKQDLFTAKPAKKIKEQLEKE 137 (203) T ss_pred -------------------CCCEEEEECCCCHHHCCCHHHHHHHHHHH T ss_conf -------------------98689996263100157978999999999 No 73 >cd01875 RhoG RhoG subfamily. RhoG is a GTPase with high sequence similarity to members of the Rac subfamily, including the regions involved in effector recognition and binding. However, RhoG does not bind to known Rac1 and Cdc42 effectors, including proteins containing a Cdc42/Rac interacting binding (CRIB) motif. Instead, RhoG interacts directly with Elmo, an upstream regulator of Rac1, in a GTP-dependent manner and forms a ternary complex with Dock180 to induce activation of Rac1. The RhoG-Elmo-Dock180 pathway is required for activation of Rac1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Thus RhoG activates Rac1 through Elmo and Dock180 to control cell morphology. RhoG has also been shown to play a role in caveolar trafficking and has a novel role in signaling the neutrophil respiratory burst stimulated by G protein-coupled receptor (GPCR) agonists. Most Rho proteins contain a lipid modification site at the C-termin Probab=97.10 E-value=0.0045 Score=37.59 Aligned_columns=178 Identities=13% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+-||++|+-.+.... ......|.|...|.....+ ++...++.+|=- .|.-.|..+- T Consensus 6 vvliGd~~VGKTsli~r~~~~~--------F~~~~~pTi~~~~~~~~~~--------~~~~v~l~iwDT-aGqe~~~~l~ 68 (191) T cd01875 6 CVVVGDGAVGKTCLLICYTTNA--------FPKEYIPTVFDNYSAQTAV--------DGRTVSLNLWDT-AGQEEYDRLR 68 (191) T ss_pred EEEEECCCCCHHHHHHHHHCCC--------CCCCCCCEEEEEEEEEEEE--------CCCEEEEEEECC-CCCHHHHHHH T ss_conf 9987079842899988875284--------2665355045546886665--------172799985148-8854467787 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +....--.. +||+-|-+++++|..=-.+|..-++++.. T Consensus 69 ~~~~~~a~~----~iivyditd~~Sf~~i~~~w~~~i~~~~~-------------------------------------- 106 (191) T cd01875 69 TLSYPQTNV----FIICFSIASPSSYENVRHKWHPEVCHHCP-------------------------------------- 106 (191) T ss_pred HHHHCCCCE----EEEEEECCCHHHHHHHHHHHHHHHHHHCC-------------------------------------- T ss_conf 876238986----99998648867889999988999997268-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHH-HHHHHHHHHHHHHHHHCCEEEE-ECCCCCCCHHHHHH Q ss_conf 532136888753267895079996187556788863588556-8999999999999871841255-21233210345655 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEE-QFDFILQFMRTLLLKHGASLIY-TTPFLANSLQSLIH 286 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE-~fDfIqQ~lRt~cLqYGAsLiY-TS~~~~~nl~~Llh 286 (523) .+|+++|-+|+|....-+-.....|+ +-....+--+.++-++|+-.+| ||++...|...+.+ T Consensus 107 ----------------~vpiiLVGNK~DL~~~~~~~~~~~e~~~~~Vs~eeg~~~a~~~~~~~y~EtSAktg~nV~e~F~ 170 (191) T cd01875 107 ----------------NVPILLVGTKKDLRNDADTLKKLKEQGQAPITPQQGGALAKQIHAVKYLECSALNQDGVKEVFA 170 (191) T ss_pred ----------------CCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH T ss_conf ----------------9679998347663112688888875102466889999999980895068864047778789999 Q ss_pred HHCCCCCCCCCCCCCCC Q ss_conf 32253224667551123 Q Fun_An_XP_0013 287 SSLGIHSLLKRQSLKHN 303 (523) Q Consensus 287 ~~lgih~ll~~~~~~a~ 303 (523) .. +-..+..+|-+.+ T Consensus 171 ~l--~r~vl~~~p~~~~ 185 (191) T cd01875 171 EA--VRAVLNPTPIKDT 185 (191) T ss_pred HH--HHHHHCCCCCCCC T ss_conf 99--9998478898878 No 74 >cd04173 Rnd2_Rho7 Rnd2/Rho7 subfamily. Rnd2/Rho7 is a member of the novel Rho subfamily Rnd, together with Rnd1/Rho6 and Rnd3/RhoE/Rho8. Rnd2/Rho7 is transiently expressed in radially migrating cells in the brain while they are within the subventricular zone of the hippocampus and cerebral cortex. These migrating cells typically develop into pyramidal neurons. Cells that exogenously expressed Rnd2/Rho7 failed to migrate to upper layers of the brain, suggesting that Rnd2/Rho7 plays a role in the radial migration and morphological changes of developing pyramidal neurons, and that Rnd2/Rho7 degradation is necessary for proper cellular migration. The Rnd2/Rho7 GEF Rapostlin is found primarily in the brain and together with Rnd2/Rho7 induces dendrite branching. Unlike Rnd1/Rho6 and Rnd3/RhoE/Rho8, which are RhoA antagonists, Rnd2/Rho7 binds the GEF Pragmin and significantly stimulates RhoA activity and Rho-A mediated cell contraction. Rnd2/Rho7 is also found to be expressed in sperma Probab=97.10 E-value=0.0015 Score=40.53 Aligned_columns=162 Identities=19% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|+.+-||++||-......-...- .|-|..+|...+ ..++....+++|=- .|...| T Consensus 4 iVvvGD~~VGKTsLl~~f~~~~F~~~y--------~PTV~~~~~~~i--------~vd~~~V~L~lWDT-AGQE~y---- 62 (222) T cd04173 4 IVVVGDAECGKTALLQVFAKDAYPGSY--------VPTVFENYTASF--------EIDKRRIELNMWDT-SGSSYY---- 62 (222) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCC--------CCEEEEEEEEEE--------EECCEEEEEEEEEC-CCCHHH---- T ss_conf 999716983378888876437106752--------441576579999--------99886999998734-887012---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) -.+.+-.++++ .++|+-|.++|-+|-.=..+|...++++-. T Consensus 63 -~~lr~~yYr~ad~~llvFdIt~~~SF~nv~~kW~~ei~~~~p------------------------------------- 104 (222) T cd04173 63 -DNVRPLAYPDSDAVLICFDISRPETLDSVLKKWQGETQEFCP------------------------------------- 104 (222) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCC------------------------------------- T ss_conf -344477633898799998658854789999988899997079------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHH-HHHHHHHHCC-EEEEECCCCCCC-HHHH Q ss_conf 453213688875326789507999618755678886358855689999999-9999987184-125521233210-3456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQF-MRTLLLKHGA-SLIYTTPFLANS-LQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~-lRt~cLqYGA-sLiYTS~~~~~n-l~~L 284 (523) .+||++|-+|+|.=+-++.-...++..-.+|.+. -..++=+.|| .-+=+|.|...| ...+ T Consensus 105 -----------------~~pIILVGnK~DLR~D~~~~~~l~~~~~~pVs~eeg~~lA~~igA~~y~EcSAk~~~n~V~ev 167 (222) T cd04173 105 -----------------NAKVVLVGCKLDMRTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVECSSRSSERSVRDV 167 (222) T ss_pred -----------------CCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHH T ss_conf -----------------984899803667658988999998568998898999999997398213653045799667899 Q ss_pred HH Q ss_conf 55 Q Fun_An_XP_0013 285 IH 286 (523) Q Consensus 285 lh 286 (523) -| T Consensus 168 F~ 169 (222) T cd04173 168 FH 169 (222) T ss_pred HH T ss_conf 99 No 75 >cd04145 M_R_Ras_like M-Ras/R-Ras-like subfamily. This subfamily contains R-Ras2/TC21, M-Ras/R-Ras3, and related members of the Ras family. M-Ras is expressed in lympho-hematopoetic cells. It interacts with some of the known Ras effectors, but appears to also have its own effectors. Expression of mutated M-Ras leads to transformation of several types of cell lines, including hematopoietic cells, mammary epithelial cells, and fibroblasts. Overexpression of M-Ras is observed in carcinomas from breast, uterus, thyroid, stomach, colon, kidney, lung, and rectum. In addition, expression of a constitutively active M-Ras mutant in murine bone marrow induces a malignant mast cell leukemia that is distinct from the monocytic leukemia induced by H-Ras. TC21, along with H-Ras, has been shown to regulate the branching morphogenesis of ureteric bud cell branching in mice. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an ali Probab=97.09 E-value=0.013 Score=34.72 Aligned_columns=154 Identities=20% Q ss_pred CCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHH Q ss_conf 42047886477987321232331111245566312256567444433420223310006774551101678717887112 Q Fun_An_XP_0013 45 PEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSF 124 (523) Q Consensus 45 psKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~ 124 (523) |.=.|+++|..+.||++|+-......-.. ++.... +-.|.-.-+.|.. ...+.+|=. .|...+ T Consensus 1 p~~Kiv~iGd~~VGKTsll~r~~~~~f~~----~~~pt~--------~~~~~k~~~v~~~----~~~l~i~Dt-~g~e~~ 63 (164) T cd04145 1 PTYKLVVVGGGGVGKSALTIQFIQSYFVT----DYDPTI--------EDSYTKQCEIDGQ----WAILDILDT-AGQEEF 63 (164) T ss_pred CCEEEEEECCCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEECCE----EEEEEEEEC-CCCCHH T ss_conf 92789998079954899999987170177----657530--------2127888988894----899988506-876001 Q ss_pred HHHHHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC Q ss_conf 3200110581012003-343330000313689999999999999985069588899999999986226887677777677 Q Fun_An_XP_0013 125 APLLKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQG 203 (523) Q Consensus 125 ~~LLk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~ 203 (523) ..+.+..+.++ .++|+-|.+++=++-. +++|..-+...-..- T Consensus 64 -----~~~~~~~~~~a~~~iivydi~~~~Sf~~-i~~w~~~i~~~~~~~------------------------------- 106 (164) T cd04145 64 -----SAMREQYMRTGEGFLLVFSVTDRGSFEE-VDKFHTQILRVKDRD------------------------------- 106 (164) T ss_pred -----HHHHHHHHCCCCEEEEEEECCCHHHHHH-HHHHHHHHHHHCCCC------------------------------- T ss_conf -----2454887238966899987699657899-999988777534899------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHH Q ss_conf 77664532136888753267895079996187556788863588556899999999999987184125521233210345 Q Fun_An_XP_0013 204 FTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQS 283 (523) Q Consensus 204 ~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~ 283 (523) .+|+++|.+|+| |+.++.-..++ .+.++=++|+..|.||.+...|... T Consensus 107 ---------------------~~piilvGNK~D----L~~~r~V~~~e-------~~~~a~~~~~~~~E~SAk~~~nV~e 154 (164) T cd04145 107 ---------------------EFPMILVGNKAD----LEHQRKVSREE-------GQELARKLKIPYIETSAKDRLNVDK 154 (164) T ss_pred ---------------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHH T ss_conf ---------------------847999800258----00122059889-------9999996599699997158988789 Q ss_pred H Q ss_conf 6 Q Fun_An_XP_0013 284 L 284 (523) Q Consensus 284 L 284 (523) + T Consensus 155 ~ 155 (164) T cd04145 155 A 155 (164) T ss_pred H T ss_conf 9 No 76 >cd04150 Arf1_5_like Arf1-Arf5-like subfamily. This subfamily contains Arf1, Arf2, Arf3, Arf4, Arf5, and related proteins. Arfs1-5 are soluble proteins that are crucial for assembling coat proteins during vesicle formation. Each contains an N-terminal myristoylated amphipathic helix that is folded into the protein in the GDP-bound state. GDP/GTP exchange exposes the helix, which anchors to the membrane. Following GTP hydrolysis, the helix dissociates from the membrane and folds back into the protein. A general feature of Arf1-5 signaling may be the cooperation of two Arfs at the same site. Arfs1-5 are generally considered to be interchangeable in function and location, but some specific functions have been assigned. Arf1 localizes to the early/cis-Golgi, where it is activated by GBF1 and recruits the coat protein COPI. It also localizes to the trans-Golgi network (TGN), where it is activated by BIG1/BIG2 and recruits the AP1, AP3, AP4, and GGA proteins. Humans, but not rodents Probab=97.09 E-value=0.0067 Score=36.53 Aligned_columns=150 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) ||++|-..+|||||+..+...+...+.|.. |..+..++..+ ..+.+|-+ .|...+ T Consensus 3 iv~lG~~~~GKTtii~~~~~~~~~~~~pTv-------------g~~~~~i~~~~-------~~l~iwD~-~Gqe~~---- 57 (159) T cd04150 3 ILMVGLDAAGKTTILYKLKLGEIVTTIPTI-------------GFNVETVEYKN-------ISFTVWDV-GGQDKI---- 57 (159) T ss_pred EEEEEECCCCHHHHHHHHHCCCEEEEECCE-------------EEEEEEEEECC-------EEEEEEEC-CCCHHH---- T ss_conf 899940898688877765337600110220-------------01588875067-------18999875-872356---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+.-++++ .+++|+|-|+. +++.++...|+..+..-... T Consensus 58 -r~~w~~y~~~~~~iI~VvD~sd~----~~~~~~~~~l~~~l~~~~~~-------------------------------- 100 (159) T cd04150 58 -RPLWRHYFQNTQGLIFVVDSNDR----ERIGEAREELQRMLNEDELR-------------------------------- 100 (159) T ss_pred -HHHHHHHCCCCCEEEEEEECCCH----HHHHHHHHHHHHHHCCCCCC-------------------------------- T ss_conf -78889862799779999854883----46899999999984230216-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHH Q ss_conf 453213688875326789507999618755678886358855689999999999998718412552123321034565 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLI 285 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Ll 285 (523) ++|++|+..|+| |+....-+|-.-.+=++.++ ++.-.++.||++.-..+...+ T Consensus 101 -----------------~~pili~~NK~D----l~~~~~~~ei~~~l~l~~~~----~~~~~i~~~SA~tG~Gi~e~~ 153 (159) T cd04150 101 -----------------DAVLLVFANKQD----LPNAMSAAEVTDKLGLHSLR----NRNWYIQATCATSGDGLYEGL 153 (159) T ss_pred -----------------CCEEEEEECCCC----CCCCCCHHHHHHHHHHHHHC----CCCEEEEEEECCCCCCHHHHH T ss_conf -----------------978999960568----64257989999897577650----596589985245688889999 No 77 >cd04176 Rap2 Rap2 subgroup. The Rap2 subgroup is part of the Rap subfamily of the Ras family. It consists of Rap2a, Rap2b, and Rap2c. Both isoform 3 of the human mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) and Traf2- and Nck-interacting kinase (TNIK) are putative effectors of Rap2 in mediating the activation of c-Jun N-terminal kinase (JNK) to regulate the actin cytoskeleton. In human platelets, Rap2 was shown to interact with the cytoskeleton by binding the actin filaments. In embryonic Xenopus development, Rap2 is necessary for the Wnt/beta-catenin signaling pathway. The Rap2 interacting protein 9 (RPIP9) is highly expressed in human breast carcinomas and correlates with a poor prognosis, suggesting a role for Rap2 in breast cancer oncogenesis. Rap2b, but not Rap2a, Rap2c, Rap1a, or Rap1b, is expressed in human red blood cells, where it is believed to be involved in vesiculation. A number of additional effector proteins for Rap2 have been identified, incl Probab=97.06 E-value=0.0098 Score=35.52 Aligned_columns=151 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||++|+....... ....-.|-+.+.+--.. ..+.....+.+|=. .|.-.|..+. T Consensus 4 IvvvGd~~VGKTsli~rf~~~~--------f~~~y~~Ti~~~~~k~i--------~~~~~~~~l~i~Dt-~G~e~~~~~~ 66 (163) T cd04176 4 VVVLGSGGVGKSALTVQFVSGT--------FIEKYDPTIEDFYRKEI--------EVDSSPSVLEILDT-AGTEQFASMR 66 (163) T ss_pred EEEEECCCCCHHHHHHHHHCCE--------ECCCCCCCCCCEEEEEE--------EECCEEEEEEEEEC-CCCCHHHHHH T ss_conf 8997079854899998876380--------07765631000047899--------88896899998746-8871245677 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +....-- ..+||+-|.+.+.+|-. ++.|...+.+....- T Consensus 67 ~~~~~~a----~~~ilvydi~~~~Sf~~-i~~~~~~i~~~~~~~------------------------------------ 105 (163) T cd04176 67 DLYIKNG----QGFIVVYSLVNQQTFQD-IKPMRDQIVRVKGYE------------------------------------ 105 (163) T ss_pred HHHCCCC----CEEEEEEECCCHHHHHH-HHHHHHHHHHHCCCC------------------------------------ T ss_conf 7425799----86999976699768899-999876567531899------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|-+|+| |+.++.-..++ ...++=++|+..|.||++...|...+ T Consensus 106 ----------------~~piilvGnK~D----l~~~r~V~~~e-------~~~~a~~~~~~y~E~SAk~~~nV~e~ 154 (163) T cd04176 106 ----------------KVPIILVGNKVD----LESEREVSSAE-------GRALAEEWGCPFMETSAKSKTMVNEL 154 (163) T ss_pred ----------------CCEEEEEECCCC----HHHHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------828999733200----11110246378-------99999963995899970479887899 No 78 >cd01898 Obg Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain. Probab=97.04 E-value=0.0046 Score=37.53 Aligned_columns=161 Identities=22% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |-+.|-...||.|||-.|.+ .+......+...+.|-++.-.-.++.=+-+.| -+...-..-. T Consensus 3 ValvG~pNvGKSTL~N~Lt~--~~~~V~~~~gtT~~~~~g~~~~~~~~~i~~vD----------------TpG~~~~~~~ 64 (170) T cd01898 3 VGLVGLPNAGKSTLLSAISN--AKPKIADYPFTTLVPNLGVVRVDDGRSFVVAD----------------IPGLIEGASE 64 (170) T ss_pred EEEEECCCCCHHHHHHHHHC--CCCEEECCCCCCCCEEEEEEEECCCCEEEEEE----------------CCCCCCCCCC T ss_conf 56642799858999989862--86112123677511013589865984389985----------------2520125422 Q ss_pred HHCCCHHHHCCE----EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC Q ss_conf 110581012003----3433300003136899999999999999850695888999999999862268876777776777 Q Fun_An_XP_0013 129 KPLLTPQSIPET----LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGF 204 (523) Q Consensus 129 k~al~~~sl~~T----LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~ 204 (523) ..-+..+.+++- +|++++|.+.+|...++++.=...|..+-.++ T Consensus 65 ~~~l~~~~l~~i~~ad~ii~vvD~~~~~~~~~~~~~i~~~l~~~~~~l-------------------------------- 112 (170) T cd01898 65 GKGLGHRFLRHIERTRLLLHVIDLSGDDDPVEDYKTIRNELELYNPEL-------------------------------- 112 (170) T ss_pred CHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCHHH-------------------------------- T ss_conf 134799999988508878999745886686889999999998612122-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 76645321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 205 TSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 205 ~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) ++-|+++|.+|+|.+. .++.+.-+.++++.+ ++...|++|.+...+++.| T Consensus 113 -------------------~~kp~iiv~NK~Dl~~--------~~~~~~~~~~~~~~~---~~~~ii~iSA~~g~gi~~L 162 (170) T cd01898 113 -------------------LEKPRIVVLNKIDLLD--------EEELFELLKELLKEL---WGKPVFPISALTGEGLDEL 162 (170) T ss_pred -------------------HCCCEEEEEECCCCCC--------HHHHHHHHHHHHHHC---CCCCEEEEECCCCCCHHHH T ss_conf -------------------1486899981656102--------440048999999844---8997899834678887899 Q ss_pred HHHHC Q ss_conf 55322 Q Fun_An_XP_0013 285 IHSSL 289 (523) Q Consensus 285 lh~~l 289 (523) +.+.+ T Consensus 163 ~~~i~ 167 (170) T cd01898 163 LRKLA 167 (170) T ss_pred HHHHH T ss_conf 99999 No 79 >cd04177 RSR1 RSR1 subgroup. RSR1/Bud1p is a member of the Rap subfamily of the Ras family that is found in fungi. In budding yeasts, RSR1 is involved in selecting a site for bud growth on the cell cortex, which directs the establishment of cell polarization. The Rho family GTPase cdc42 and its GEF, cdc24, then establish an axis of polarized growth by organizing the actin cytoskeleton and secretory apparatus at the bud site. It is believed that cdc42 interacts directly with RSR1 in vivo. In filamentous fungi, polar growth occurs at the tips of hypha and at novel growth sites along the extending hypha. In Ashbya gossypii, RSR1 is a key regulator of hyphal growth, localizing at the tip region and regulating in apical polarization of the actin cytoskeleton. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key featu Probab=97.03 E-value=0.011 Score=35.31 Aligned_columns=153 Identities=18% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+......+-.. ...- -+|=.| ..--..++....+.+|=. .|.-.|..+. T Consensus 4 iiliGd~~VGKTsli~r~~~~~F~~----~~~~----------Ti~~~~--~k~i~v~~~~~~l~iwDt-aG~e~~~~l~ 66 (168) T cd04177 4 IVVLGAGGVGKSALTVQFVQNVFIE----SYDP----------TIEDSY--RKQVEIDGRQCDLEILDT-AGTEQFTAMR 66 (168) T ss_pred EEEECCCCCCHHHHHHHHHCCEECC----CCCC----------CCCCCE--EEEEEECCEEEEEEEEEC-CCCCHHHHHH T ss_conf 8998079954899999887180067----6454----------101103--578989896999998727-9871245687 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--.. ++++-|.+.+-+| +.|.+|..-+.....+- T Consensus 67 ~~~~~~a~~----~ilvydit~~~Sf-~~l~~~~~~i~~~~~~~------------------------------------ 105 (168) T cd04177 67 ELYIKSGQG----FLLVYSVTSEASL-NELGELREQVLRIKDSD------------------------------------ 105 (168) T ss_pred HHHCCCCCE----EEEEEECCCHHHH-HHHHHHHHHHHHHCCCC------------------------------------ T ss_conf 875359985----8999856997899-99999999998631899------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCCCCHHHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255-21233210345655 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIY-TTPFLANSLQSLIH 286 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiY-TS~~~~~nl~~Llh 286 (523) .+|+++|.+|+| |+.++.-..| -.+.+|-++|+.-|| ||.+...|...+.+ T Consensus 106 ----------------~~piilvGNK~D----L~~~r~v~~~-------e~~~~a~~~~~~~~~E~SAk~g~nV~e~F~ 157 (168) T cd04177 106 ----------------NVPMVLVGNKAD----LEDDRQVSRE-------DGVSLSQQWGNVPFYETSARKRTNVDEVFI 157 (168) T ss_pred ----------------CCEEEEECCCCC----CCCCCCCCHH-------HHHHHHHHHCCCCEEEEEECCCCCHHHHHH T ss_conf ----------------958999802478----4335768989-------999999981698358886048988789999 No 80 >KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2 [Intracellular trafficking, secretion, and vesicular transport, Cytoskeleton] Probab=96.95 E-value=0.011 Score=35.16 Aligned_columns=146 Identities=24% Q ss_pred HHHHHHHHHCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEE Q ss_conf 98887664048842047886477987321232331111245566312256567444433420223310006774551101 Q Fun_An_XP_0013 33 SMLDSVANGKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARV 112 (523) Q Consensus 33 siL~~vss~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~ 112 (523) +||.....+.| +-.||+||=+++||||++.++.+..... +.| -+|| +++.....+ .++ T Consensus 5 silrk~k~ker--E~riLiLGLdNsGKTti~~kl~~~~~~~----------i~p-----t~gf---~Iktl~~~~--~~L 62 (185) T KOG0073 5 SILRKQKLKER--EVRILILGLDNSGKTTIVKKLLGEDTDT----------ISP-----TLGF---QIKTLEYKG--YTL 62 (185) T ss_pred HHHHHHHHHHC--CCEEEEEECCCCCHHHHHHHHCCCCCCC----------CCC-----EECC---EEEEEEECC--EEE T ss_conf 87787654310--4257898218985677768660787220----------176-----2232---144444316--289 Q ss_pred EEEEECCCCHHHHHHHHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC Q ss_conf 6787178871123200110581012003-343330000313689999999999999985069588899999999986226 Q Fun_An_XP_0013 113 SAYLLSEPSLSFAPLLKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRK 191 (523) Q Consensus 113 svyiL~d~d~~~~~LLk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~ 191 (523) ++|=+ .|.-..-..- +.-+..| -+|.++|-|+ +..|+++.+..++-- T Consensus 63 ~iwDv-GGq~~lr~~W-----~nYfestdglIwvvDssD--------------------------~~r~~e~~~~L~~lL 110 (185) T KOG0073 63 NIWDV-GGQKTLRSYW-----KNYFESTDGLIWVVDSSD--------------------------RMRMQECKQELTELL 110 (185) T ss_pred EEEEE-CCCEEEHHHH-----HHHHHCCCCEEEEEECCC--------------------------HHHHHHHHHHHHHHH T ss_conf 99985-4841000011-----003431492799995554--------------------------356999999999874 Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHH--------------HHHHHHCCCC--------- Q ss_conf 88767777767777664532136888753267895079996187556--------------7888635885--------- Q Fun_An_XP_0013 192 RGMDSSSGGAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKI--------------EKLEKDHGWH--------- 248 (523) Q Consensus 192 ~~~~~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i--------------~~LEKe~dyk--------- 248 (523) -+.-- .|-|++|++.|.|.- +.|.|.|+|+ T Consensus 111 ~eerl---------------------------aG~~~Lvlank~dl~~~l~~~~i~~~~~L~~l~ks~~~~l~~cs~~tg 163 (185) T KOG0073 111 VEERL---------------------------AGAPLLVLANKQDLPGALSLEEISKALDLEELAKSHHWRLVKCSAVTG 163 (185) T ss_pred CCCCC---------------------------CCCCEEEEEECCCCCCCCCHHHHHHHHCHHHHCCCCCEEEEEEECCCC T ss_conf 13311---------------------------477538886312778641476778771546614545623899732353 Q ss_pred ---HHHHHHHHHHH Q ss_conf ---56899999999 Q Fun_An_XP_0013 249 ---EEQFDFILQFM 259 (523) Q Consensus 249 ---dE~fDfIqQ~l 259 (523) .+-||++.+-+ T Consensus 164 e~l~~gidWL~~~l 177 (185) T KOG0073 164 EDLLEGIDWLCDDL 177 (185) T ss_pred CCHHHHHHHHHHHH T ss_conf 13688999999999 No 81 >cd04133 Rop_like Rop subfamily. The Rop (Rho-related protein from plants) subfamily plays a role in diverse cellular processes, including cytoskeletal organization, pollen and vegetative cell growth, hormone responses, stress responses, and pathogen resistance. Rops are able to regulate several downstream pathways to amplify a specific signal by acting as master switches early in the signaling cascade. They transmit a variety of extracellular and intracellular signals. Rops are involved in establishing cell polarity in root-hair development, root-hair elongation, pollen-tube growth, cell-shape formation, responses to hormones such as abscisic acid (ABA) and auxin, responses to abiotic stresses such as oxygen deprivation, and disease resistance and disease susceptibility. An individual Rop can have a unique function or an overlapping function shared with other Rop proteins; in addition, a given Rop-regulated function can be controlled by one or multiple Rop proteins. For example, Probab=96.93 E-value=0.0074 Score=36.26 Aligned_columns=156 Identities=18% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |++||..+-||++|+-......-...- .|-|+..|-... ..+....++.+|=- .|.-.| T Consensus 4 iv~iGd~~VGKTsLi~rf~~~~F~~~~--------~pTi~~~~~~~i--------~~~~~~v~l~IwDT-aGqe~~---- 62 (176) T cd04133 4 CVTVGDGAVGKTCMLICYTSNKFPTDY--------IPTVFDNFSANV--------SVDGNTVNLGLWDT-AGQEDY---- 62 (176) T ss_pred EEEECCCCCCHHHHHHHHHCCEECCCC--------CCEEEEEEEEEE--------EECCEEEEEEEEEC-CCCHHH---- T ss_conf 999717984489988887538016863--------533531113678--------88894899998756-887146---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..+++. .++|+-|.+.+-+|-.-+++|+.-+|.+.. T Consensus 63 -~~l~~~~~r~a~~~ilvydvt~~~Sf~~~~~~w~~~~~~~~~------------------------------------- 104 (176) T cd04133 63 -NRLRPLSYRGADVFVLAFSLISRASYENVLKKWVPELRHYAP------------------------------------- 104 (176) T ss_pred -HHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCC------------------------------------- T ss_conf -788887411447269997448722079999998999997279------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHH---HHHHHHHHHHHHHCCE-EEEECCCCCCCHHH Q ss_conf 4532136888753267895079996187556788863588556899---9999999999871841-25521233210345 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFD---FILQFMRTLLLKHGAS-LIYTTPFLANSLQS 283 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fD---fIqQ~lRt~cLqYGAs-LiYTS~~~~~nl~~ 283 (523) .+|+++|-+|+| |+.++.+-.++-. .-.+--..++-++|+. .|-||.|...|.+. T Consensus 105 -----------------~~piiLVGNK~D----L~~~r~~~~~~~~~~~v~~~e~~~~a~~~~~~~y~EtSAktg~nV~e 163 (176) T cd04133 105 -----------------NVPIVLVGTKLD----LRDDKQYLADHPGASPITTAQGEELRKQIGAAAYIECSSKTQQNVKA 163 (176) T ss_pred -----------------CCEEEEEECCCC----CHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHH T ss_conf -----------------948999705755----11124566530133543678999999963997489975137878789 Q ss_pred H Q ss_conf 6 Q Fun_An_XP_0013 284 L 284 (523) Q Consensus 284 L 284 (523) + T Consensus 164 ~ 164 (176) T cd04133 164 V 164 (176) T ss_pred H T ss_conf 9 No 82 >cd01883 EF1_alpha Eukaryotic elongation factor 1 (EF1) alpha subfamily. EF1 is responsible for the GTP-dependent binding of aminoacyl-tRNAs to the ribosomes. EF1 is composed of four subunits: the alpha chain which binds GTP and aminoacyl-tRNAs, the gamma chain that probably plays a role in anchoring the complex to other cellular components and the beta and delta (or beta') chains. This subfamily is the alpha subunit, and represents the counterpart of bacterial EF-Tu for the archaea (aEF1-alpha) and eukaryotes (eEF1-alpha). eEF1-alpha interacts with the actin of the eukaryotic cytoskeleton and may thereby play a role in cellular transformation and apoptosis. EF-Tu can have no such role in bacteria. In humans, the isoform eEF1A2 is overexpressed in 2/3 of breast cancers and has been identified as a putative oncogene. This subfamily also includes Hbs1, a G protein known to be important for efficient growth and protein synthesis under conditions of limiting translation initiation in Probab=96.89 E-value=0.0032 Score=38.56 Aligned_columns=148 Identities=25% Q ss_pred EEEEECCCCCCCEEHHHHH---------HCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE-EEEEECCCCCCCCE------ Q ss_conf 4788647798732123233---------1111245566312256567444433420223-31000677455110------ Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTL---------AADSSDPSLSNDKRKGRVPPVANQFALGYTY-QDVLDADHEDTLAR------ 111 (523) Q Consensus 48 nilvLGg~~~~k~tll~~L---------s~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y-~dV~D~D~eD~~aR------ 111 (523) |++++|---+||+||.+.| ...+..........++ ...|+| +|-.+++++--.|- T Consensus 1 Ni~iiGHVD~GKSTL~g~LL~~~g~v~~~~~~~~~~~s~~~g~~---------s~~~a~~~D~~~~ErerGiTi~~~~~~ 71 (219) T cd01883 1 NLVVIGHVDAGKSTTTGHLLYLLGGVDKRTIEKYEKEAKEMGKG---------SFKYAWVLDTLKEERERGVTIDVGLAK 71 (219) T ss_pred CEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC---------CCHHHEECCCCHHHHHCCCEEEEEEEE T ss_conf 96899723888688999999984886788999999988760775---------200000003661266569608888999 Q ss_pred -----EEEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHH----HHHHHHHHHHHHHHHHHHCCCCHHHHHHH Q ss_conf -----167871788711232001105810120033433300003136----89999999999999985069588899999 Q Fun_An_XP_0013 112 -----VSAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWT----WIRRLREWVRLLRHVLISLDDETKIVMEE 182 (523) Q Consensus 112 -----~svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt----~me~L~~W~~vLr~hi~sL~~e~~~~mee 182 (523) -.+-++ --|.|+...+-..+.-+..+..|+++-.-..-|- .+-|-++-+.+++. T Consensus 72 fet~~~~~~ii--D~PGH~dfi~nmi~Gas~aD~AiLVVdA~~g~fE~~~~~~~QTreH~~l~~~--------------- 134 (219) T cd01883 72 FETEKYRFTIL--DAPGHRDFVPNMITGASQADVAVLVVDARKGEFEAGFEKGGQTREHALLART--------------- 134 (219) T ss_pred EEECCCEEEEE--ECCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHCCCCCCCHHHHHHHHHHH--------------- T ss_conf 97089389997--0831788999999998751668999876888200034557217999999998--------------- Q ss_pred HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC-EEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHH Q ss_conf 999986226887677777677776645321368887532678950-7999618755678886358855689999999999 Q Fun_An_XP_0013 183 NLTEWRDRKRGMDSSSGGAQGFTSSAGPVTIPLGPGEWDEGLGIP-MCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRT 261 (523) Q Consensus 183 ~~~~~~e~~~~~~~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGiP-i~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt 261 (523) |||+ |+|++.|-|.+ +.+|.++.|+.|.+-++. T Consensus 135 -----------------------------------------lGv~~iIVavNKmD~v-----~~~~~~~rf~~I~~~~~~ 168 (219) T cd01883 135 -----------------------------------------LGVKQLIVAVNKMDDV-----TVNWSEERYDEIKKELSP 168 (219) T ss_pred -----------------------------------------CCCCEEEEEEECCCCC-----CCCCCHHHHHHHHHHHHH T ss_conf -----------------------------------------0898189998424689-----985027899999999999 Q ss_pred HHHHHC Q ss_conf 998718 Q Fun_An_XP_0013 262 LLLKHG 267 (523) Q Consensus 262 ~cLqYG 267 (523) |+.+.| T Consensus 169 ~l~~~g 174 (219) T cd01883 169 FLKKVG 174 (219) T ss_pred HHHHHC T ss_conf 999838 No 83 >cd01888 eIF2_gamma eIF2-gamma (gamma subunit of initiation factor 2). eIF2 is a heterotrimeric translation initiation factor that consists of alpha, beta, and gamma subunits. The GTP-bound gamma subunit also binds initiator methionyl-tRNA and delivers it to the 40S ribosomal subunit. Following hydrolysis of GTP to GDP, eIF2:GDP is released from the ribosome. The gamma subunit has no intrinsic GTPase activity, but is stimulated by the GTPase activating protein (GAP) eIF5, and GDP/GTP exchange is stimulated by the guanine nucleotide exchange factor (GEF) eIF2B. eIF2B is a heteropentamer, and the epsilon chain binds eIF2. Both eIF5 and eIF2B-epsilon are known to bind strongly to eIF2-beta, but have also been shown to bind directly to eIF2-gamma. It is possible that eIF2-beta serves simply as a high-affinity docking site for eIF5 and eIF2B-epsilon, or that eIF2-beta serves a regulatory role. eIF2-gamma is found only in eukaryotes and archaea. It is closely related to SelB, the sel Probab=96.87 E-value=0.0032 Score=38.53 Aligned_columns=170 Identities=14% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCC-----------CCCCCCCCCCCCEEEEEEEECCCCCCCCEEE--- Q ss_conf 47886477987321232331111245566312256-----------5674444334202233100067745511016--- Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKG-----------RVPPVANQFALGYTYQDVLDADHEDTLARVS--- 113 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kG-----------r~ppia~~~~LgY~Y~dV~D~D~eD~~aR~s--- 113 (523) ||.++|---+||+||+..|.+....+ ...++.+| ...--.......|.|..+.+.....+ .|+. T Consensus 2 Ni~iiGHVDhGKSTL~~~Ltg~~~~~-~~~e~ergITiklG~a~~~i~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~ 79 (203) T cd01888 2 NIGTIGHVAHGKSTLVKALSGVWTVR-FKEELERNITIKLGYANAKIYKCPNCGCPRPYCYRSKEDSPECEC-PGCGGET 79 (203) T ss_pred EEEEEEEECCCHHHHHHHHHHHHHHH-HHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCHHEECCCCCCCCCC-CCCCCCE T ss_conf 28999873088789999873323443-267876276012002344333101212221000000123310001-3566411 Q ss_pred -----EEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHH-HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH Q ss_conf -----78717887112320011058101200334333000031368-999999999999998506958889999999998 Q Fun_An_XP_0013 114 -----AYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTW-IRRLREWVRLLRHVLISLDDETKIVMEENLTEW 187 (523) Q Consensus 114 -----vyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~-me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~ 187 (523) +-++ --|.|+.+++-.++--+..+-.++++ |-.+ .+ +.|-++-+.+++. T Consensus 80 ~~~r~itii--D~PGH~dfi~nmi~Gas~~D~aiLvV-~a~~--g~~~~QT~eH~~~~~~-------------------- 134 (203) T cd01888 80 KLVRHVSFV--DCPGHEILMATMLSGAAVMDGALLLI-AANE--PCPQPQTSEHLAALEI-------------------- 134 (203) T ss_pred EEEEEEEEE--ECCCHHHHHHHHHHHHHHCCEEEEEE-ECCC--CCCCHHHHHHHHHHHH-------------------- T ss_conf 234688987--65767899999987541137689998-6698--8540468999999997-------------------- Q ss_pred HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC-EEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH Q ss_conf 6226887677777677776645321368887532678950-799961875567888635885568999999999999871 Q Fun_An_XP_0013 188 RDRKRGMDSSSGGAQGFTSSAGPVTIPLGPGEWDEGLGIP-MCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKH 266 (523) Q Consensus 188 ~e~~~~~~~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGiP-i~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqY 266 (523) ||++ ++||.+|.|.+ +.+|..+.++-|..+|+-+++. T Consensus 135 ------------------------------------~gi~~iiv~iNK~Dl~-----~~~~~~~~~~~i~~~l~~~~~~- 172 (203) T cd01888 135 ------------------------------------MGLKHIIIVQNKIDLV-----KEEQALENYEQIKKFVKGTIAE- 172 (203) T ss_pred ------------------------------------HCCCCEEEEEECCCCC-----CHHHHHHHHHHHHHHHCCCCCC- T ss_conf ------------------------------------1899438998537899-----8657999999999973214688- Q ss_pred CCEEEEECCCCCCCHHHHHH Q ss_conf 84125521233210345655 Q Fun_An_XP_0013 267 GASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 267 GAsLiYTS~~~~~nl~~Llh 286 (523) .+..|..|.+.-.|.+.|+. T Consensus 173 ~~~iipiSA~~G~nId~Lle 192 (203) T cd01888 173 NAPIIPISAQLKYNIDVLLE 192 (203) T ss_pred CEEEEECCCCCCCCHHHHHH T ss_conf 71388622555789889999 No 84 >cd04147 Ras_dva Ras-dva subfamily. Ras-dva (Ras - dorsal-ventral anterior localization) subfamily consists of a set of proteins characterized only in Xenopus leavis, to date. In Xenopus Ras-dva expression is activated by the transcription factor Otx2 and begins during gastrulation throughout the anterior ectoderm. Ras-dva expression is inhibited in the anterior neural plate by factor Xanf1. Downregulation of Ras-dva results in head development abnormalities through the inhibition of several regulators of the anterior neural plate and folds patterning, including Otx2, BF-1, Xag2, Pax6, Slug, and Sox9. Downregulation of Ras-dva also interferes with the FGF-8a signaling within the anterior ectoderm. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Probab=96.85 E-value=0.019 Score=33.82 Aligned_columns=151 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |++||+.+-||++|+-.+-...... ++.. -++-.|.-...-|... -.+.+|=. .|...| T Consensus 2 IvllGd~~VGKTsLi~rf~~~~F~~----~y~~----------Ti~~~~~k~~~v~~~~--v~l~iwDT-aGqe~f---- 60 (198) T cd04147 2 LVFMGAAGVGKTALIQRFLYDTFEP----KYRR----------TVEEMHRKEYEVGGVS--LTLDILDT-SGSYSF---- 60 (198) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CCCCCEEEEEEECCEE--EEEEEECC-CCHHHH---- T ss_conf 7888179832899998876181077----5232----------2001046789888968--99997328-770332---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .+||+-|.+.+.+|- .++.|...+.+.-..- T Consensus 61 -~~l~~~~~r~a~~~ilVyDit~~~SF~-~v~~w~~~i~~~~~~~----------------------------------- 103 (198) T cd04147 61 -PAMRKLSIQNSDAFALVYAVDDPESFE-EVERLREEILEVKEDK----------------------------------- 103 (198) T ss_pred -HHHHHHHHCCCCCEEEEEECCCHHHHH-HHHHHHHHHHHHCCCC----------------------------------- T ss_conf -347677623788079998647977899-9999999999851899----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH-HHCCEEEEECCCCCCCHHHH Q ss_conf 453213688875326789507999618755678886358855689999999999998-71841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLL-KHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cL-qYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|-.|||. |+.++.-..++- +.+|- .||+..|-||++...|...+ T Consensus 104 -----------------~~pivLVGNK~Dl---l~~~R~V~~~e~-------~~~a~~~~~~~f~EtSAk~g~nV~e~ 154 (198) T cd04147 104 -----------------FVPIVVVGNKADS---LEEERQVPAKDA-------LSTVELDWNCGFVETSAKDNENVLEV 154 (198) T ss_pred -----------------CCEEEEEECCCCC---CCCCCCCCHHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf -----------------9889997226766---221674678999-------99999847993899851478887899 No 85 >cd01895 EngA2 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability. Probab=96.83 E-value=0.024 Score=33.15 Aligned_columns=158 Identities=20% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCC----CCCCEEEEEEECCCCHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774----55110167871788711 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHE----DTLARVSAYLLSEPSLS 123 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~e----D~~aR~svyiL~d~d~~ 123 (523) +|.++|-...||+||+..|.+.. ........|. -....+..+...+.. |+ +-+.-..--+.+.. T Consensus 4 ~I~liG~~NvGKStL~N~l~~~~---~~~~s~~~gt--------T~~~~~~~~~~~~~~~~l~Dt-pG~~~~~~~~~~~e 71 (174) T cd01895 4 RIAIIGRPNVGKSSLVNALLGEE---RVIVSDIAGT--------TRDSIDVPFEYDGKKYTLIDT-AGIRRKGKVEEGIE 71 (174) T ss_pred EEEEEECCCCCHHHHHHHHHCCC---CCEECCCCCC--------EEEEEEEEEEECCEEEEEECC-CCCCCCCCCCCHHH T ss_conf 88998318998889999985676---3021378972--------142368999887858998727-66431111000045 Q ss_pred HHHHHHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC Q ss_conf 23200110581012003-34333000031368999999999999998506958889999999998622688767777767 Q Fun_An_XP_0013 124 FAPLLKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQ 202 (523) Q Consensus 124 ~~~LLk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~ 202 (523) +-...+.. +.+..+ ++++++|-+.|.+ ++=..++.++++ T Consensus 72 ~~~~~~~~---~~i~~~divl~viD~~~~~~--~~d~~i~~~l~~----------------------------------- 111 (174) T cd01895 72 KYSVLRTL---KAIERADVVLLVIDATEGIT--EQDLRIAGLILE----------------------------------- 111 (174) T ss_pred HHHHHHHH---HHHHCCCEEEEEECCCCCCC--HHHHHHHHHHHH----------------------------------- T ss_conf 89999999---98622867999843778988--889999999996----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH-HCCEEEEECCCCCCCH Q ss_conf 777664532136888753267895079996187556788863588556899999999999987-1841255212332103 Q Fun_An_XP_0013 203 GFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLK-HGASLIYTTPFLANSL 281 (523) Q Consensus 203 ~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLq-YGAsLiYTS~~~~~nl 281 (523) .|+|+++|.+|+|.++ -..++++.+++.++..+-+ .+.-.|++|.+.-.++ T Consensus 112 ---------------------~~~pii~v~NKiDli~-------~~~~~~~~~~~~~~~~~~~~~~~~ii~iSAktG~gi 163 (174) T cd01895 112 ---------------------EGKALVIVVNKWDLVE-------KDSKTMKEFKKEIRRKLPFLDYAPIVFISALTGQGV 163 (174) T ss_pred ---------------------CCCCEEEEEEECCCCC-------CCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCH T ss_conf ---------------------4897999864012347-------865468999999998720168976688615679988 Q ss_pred HHHH Q ss_conf 4565 Q Fun_An_XP_0013 282 QSLI 285 (523) Q Consensus 282 ~~Ll 285 (523) +.|+ T Consensus 164 d~L~ 167 (174) T cd01895 164 DKLF 167 (174) T ss_pred HHHH T ss_conf 8999 No 86 >cd04111 Rab39 Rab39 subfamily. Found in eukaryotes, Rab39 is mainly found in epithelial cell lines, but is distributed widely in various human tissues and cell lines. It is believed to be a novel Rab protein involved in regulating Golgi-associated vesicular transport during cellular endocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=96.83 E-value=0.025 Score=33.03 Aligned_columns=152 Identities=13% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|....||++|+..+.... ....-.-.. |.+|...-|.=.|... .++.+|=. -|.-.| T Consensus 5 IviiGd~~VGKTsli~rf~~~~-------F~~~~~~Ti-----g~df~~k~v~i~dgk~--v~L~IwDT-aGqE~f---- 65 (211) T cd04111 5 LIVIGDSTVGKSSLLKRFTEGR-------FAEVSDPTV-----GVDFFSRLIEIEPGVR--IKLQLWDT-AGQERF---- 65 (211) T ss_pred EEEEECCCCCHHHHHHHHHCCE-------ECCCCCCCE-----EEEEEEEEEEECCCCE--EEEEEEEC-CCCHHH---- T ss_conf 9998269854899998877082-------167656502-----4688899999617847--99998636-997156---- Q ss_pred HHCCCHHHHCCEE-EEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 1105810120033-433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPETL-VVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~TL-VvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+++.-++++. +++|.|.+.+-+| +.|..|+.-++.++..- T Consensus 66 -~si~~~yyr~a~g~ilVyDit~~~SF-e~i~~w~~ei~~~~~~~----------------------------------- 108 (211) T cd04111 66 -RSITRSYYRNSVGVLLVFDITNRESF-EHVHDWLEEARSHIQPH----------------------------------- 108 (211) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCCC----------------------------------- T ss_conf -88888860189889999866997789-99999999999851899----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|-+|+|. +++-..=.+--+.+|-++|+..|.||.|...|...+ T Consensus 109 -----------------~~~~iLVGNK~DL-----------~~~R~Vs~eea~~~A~~~~~~f~EtSAktg~nV~e~ 157 (211) T cd04111 109 -----------------RPVFILVGHKCDL-----------ESQRQVTREEAEKLAKDLGMKYIETSARTGDNVEEA 157 (211) T ss_pred -----------------CCEEEEECCCCCH-----------HHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf -----------------8589997165341-----------333012489999999966996999963589888999 No 87 >cd01892 Miro2 Miro2 subfamily. Miro (mitochondrial Rho) proteins have tandem GTP-binding domains separated by a linker region containing putative calcium-binding EF hand motifs. Genes encoding Miro-like proteins were found in several eukaryotic organisms. This CD represents the putative GTPase domain in the C terminus of Miro proteins. These atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. Most Rho proteins contain a lipid modification site at the C-terminus; however, Miro is one of few Rho subfamilies that lack this feature. Probab=96.82 E-value=0.012 Score=34.98 Aligned_columns=150 Identities=25% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .++|||..+.||++|+-..-... .....-.|-|...|..-=..++ +..-.+-.|-...-+.+ T Consensus 6 k~~vlGd~gVGKTsll~rfv~~~-------F~~~~y~~Tig~~f~~k~v~v~-------g~~~~l~l~Dtagqe~~---- 67 (169) T cd01892 6 LCFVLGAKGSGKSALLRAFLGRS-------FSLNAYSPTIKPRYAVNTVEVY-------GQEKYLILREVGEDEVA---- 67 (169) T ss_pred EEEEECCCCCCHHHHHHHHHCCC-------CCCCCCCCCCCCEEEEEEEEEC-------CEEEEEEEECCCCHHHH---- T ss_conf 99998089964899999985687-------4666211520231679888876-------74789985115730345---- Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 0110581012003-343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) .++.+..+... .++||-|-+.|-+| +.+..|.++....+ T Consensus 68 --~~l~~~~~~~a~~~ilVYDit~~~SF---------------------------~~i~~~~~~~~~~~----------- 107 (169) T cd01892 68 --ILLNDAELAACDVACLVYDSSDPKSF---------------------------SYCAEVYKKYFMLG----------- 107 (169) T ss_pred --HHHHHHHCCCCCEEEEEEECCCHHHH---------------------------HHHHHHHHHCCCCC----------- T ss_conf --44313220588789999867997899---------------------------99999998604899----------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEE-EEECCCCCCCHHHH Q ss_conf 6453213688875326789507999618755678886358855689999999999998718412-55212332103456 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASL-IYTTPFLANSLQSL 284 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsL-iYTS~~~~~nl~~L 284 (523) -||+++|-+|+| |+..+.-..++= +.||=++|... |.||.|...|...+ T Consensus 108 ------------------~ipiilVGNK~D----L~~~RqVs~~e~-------~~~a~~~g~~~~~e~SAKtg~nV~e~ 157 (169) T cd01892 108 ------------------EIPCLFVAAKAD----LDEQQQRYEVQP-------DEFCRKLGLPPPLHFSSKLGDSSNEL 157 (169) T ss_pred ------------------CCEEEEEECCCC----CCCCCCCCCCCH-------HHHHHHCCCCCCEEEEECCCCCHHHH T ss_conf ------------------955999830367----755563363376-------89999629996368870179998999 No 88 >cd04129 Rho2 Rho2 subfamily. Rho2 is a fungal GTPase that plays a role in cell morphogenesis, control of cell wall integrity, control of growth polarity, and maintenance of growth direction. Rho2 activates the protein kinase C homolog Pck2, and Pck2 controls Mok1, the major (1-3) alpha-D-glucan synthase. Together with Rho1 (RhoA), Rho2 regulates the construction of the cell wall. Unlike Rho1, Rho2 is not an essential protein, but its overexpression is lethal. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for proper intracellular localization via membrane attachment. As with other Rho family GTPases, the GDP/GTP cycling is regulated by GEFs (guanine nucleotide exchange factors), GAPs (GTPase-activating proteins) and GDIs (guanine nucleotide dissociation inhibitors). Probab=96.80 E-value=0.019 Score=33.71 Aligned_columns=162 Identities=14% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |++||..+-||++|+-.+....-.... .|-|...|-... ..++...++.+|=- .|.-.|..+- T Consensus 4 ivliGd~~VGKTsL~~r~~~~~F~~~~--------~pTi~~~~~~~i--------~v~~~~v~l~iwDT-aGqe~~~~l~ 66 (187) T cd04129 4 LVIVGDGACGKTSLLSVFTLGEFPEEY--------HPTVFENYVTDC--------RVDGKPVQLALWDT-AGQEEYERLR 66 (187) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCC--------CCCEEEEEEEEE--------EECCEEEEEEEEEC-CCCCHHHHHH T ss_conf 899825984389999998617327763--------660366567744--------67786899988655-7652157899 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +.....-. .++|+-|.+.|.+|..=-++|+..++.+. + T Consensus 67 ~~~~~~a~----~~ilvydi~~~~Sf~~i~~~w~~~~~~~~-----~--------------------------------- 104 (187) T cd04129 67 PLSYSKAH----VILIGFAVDTPDSLENVRTKWIEEVRRYC-----P--------------------------------- 104 (187) T ss_pred HHHHCCCC----EEEEEEECCCHHHHHHHHHHHHHHHHHHC-----C--------------------------------- T ss_conf 98706997----89999633885678888898899999836-----8--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC-EEEEECCCCCCCHHHHHH Q ss_conf 532136888753267895079996187556788863588556899999999999987184-125521233210345655 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGA-SLIYTTPFLANSLQSLIH 286 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGA-sLiYTS~~~~~nl~~Llh 286 (523) .+|+++|-+|+|.-+.-......+.+++--..+-. .++-+.|+ .-|.||.+...|.+.+.+ T Consensus 105 ----------------~~piiLvGnK~DL~~~~~~~~~~~~~r~v~~~e~~-~~a~~~~~~~y~EtSAktg~nV~e~Fe 166 (187) T cd04129 105 ----------------NVPVILVGLKKDLRQDAVAKEEYRTQRFVPIQQGK-RVAKEIGAKKYMECSALTGEGVDDVFE 166 (187) T ss_pred ----------------CCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHH-HHHHHCCCCEEEEEECCCCCCHHHHHH T ss_conf ----------------94499983588711234432101110568989999-999972895478863357878789999 No 89 >cd01891 TypA_BipA TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella typhimurium after exposure to bactericidal/permeability-inducing protein (a cationic antimicrobial protein produced by neutrophils), and has since been identified in E. coli as well. The properties thus far described for BipA are related to its role in the process of pathogenesis by enteropathogenic E. coli. It appears to be involved in the regulation of several processes important for infection, including rearrangements of the cytoskeleton of the host, bacterial resistance to host defense peptides, flagellum-mediated cell motility, and expression of K5 capsular genes. It has been proposed that BipA may utilize a novel mechanism to regulate the expression of target genes. In addition, BipA from enteropathogenic E. co Probab=96.78 E-value=0.011 Score=35.32 Aligned_columns=149 Identities=24% Q ss_pred EEEEEECCCCCCCEEHHHHH---HCCCCCC---------CCCCCCCCCCCCCCCCCCCCCE--EEEEEEECCCCCCCCEE Q ss_conf 04788647798732123233---1111245---------5663122565674444334202--23310006774551101 Q Fun_An_XP_0013 47 KNLLILGGTPESQREFLDTL---AADSSDP---------SLSNDKRKGRVPPVANQFALGY--TYQDVLDADHEDTLARV 112 (523) Q Consensus 47 KnilvLGg~~~~k~tll~~L---s~~~~~~---------~~~~d~~kGr~ppia~~~~LgY--~Y~dV~D~D~eD~~aR~ 112 (523) +||.++|---+|||||++.| ++..... +.+.|+.+| +...+....++| ..+++.| T Consensus 3 RNv~iiGHVDhGKTTL~~~ll~~tg~~~~~~~~~~~~~D~~~~E~eRG-ITI~~~~~~~~~~~~~~~~ID---------- 71 (194) T cd01891 3 RNIAIIAHVDHGKTTLVDALLKQSGTFRENEEVEERVMDSNDLERERG-ITILAKNTAVTYKDTKINIVD---------- 71 (194) T ss_pred EEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHCC-EEEEEEEEEEEEECEEEEEEE---------- T ss_conf 078998540488689999999982631000011000105516632210-457787789875070799975---------- Q ss_pred EEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCC--CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC Q ss_conf 6787178871123200110581012003343330000--31368999999999999998506958889999999998622 Q Fun_An_XP_0013 113 SAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWS--DPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDR 190 (523) Q Consensus 113 svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS--~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~ 190 (523) .|.|+...+-....-+.-+-.|+++--.. .|+| ++......+ T Consensus 72 --------tPGH~dF~~ev~r~~~~~DgaiLVVdA~eGv~~QT-----------------------~e~l~~A~~----- 115 (194) T cd01891 72 --------TPGHADFGGEVERVLSMVDGVLLLVDASEGPMPQT-----------------------RFVLKKALE----- 115 (194) T ss_pred --------CCHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHH-----------------------HHHHHHHHH----- T ss_conf --------72345679999999887075888971788855278-----------------------999999996----- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCE- Q ss_conf 6887677777677776645321368887532678950799961875567888635885568999999999999871841- Q Fun_An_XP_0013 191 KRGMDSSSGGAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGAS- 269 (523) Q Consensus 191 ~~~~~~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAs- 269 (523) +|+|++||+.|+|. -+..++-+..-+|...++||+. T Consensus 116 ---------------------------------~~ip~iv~iNKiDr----------~~a~~~~v~~e~~~l~~~~~~~~ 152 (194) T cd01891 116 ---------------------------------LGLKPIVVINKIDR----------PDARPEEVVDEVFDLFIELGATE 152 (194) T ss_pred ---------------------------------CCCCEEEEECCCCC----------CCCCHHHHHHHHHHHHHHCCCCC T ss_conf ---------------------------------58968999715778----------77788899999999874248985 Q ss_pred ------EEEECCCCC----------CCHHHHH Q ss_conf ------255212332----------1034565 Q Fun_An_XP_0013 270 ------LIYTTPFLA----------NSLQSLI 285 (523) Q Consensus 270 ------LiYTS~~~~----------~nl~~Ll 285 (523) .+|.|.+.. .|...|+ T Consensus 153 ~~~d~Pii~~SA~~g~~~~~~~~~~~~i~~Ll 184 (194) T cd01891 153 EQLDFPVLYASAKNGWASLNLEDPSEDLEPLF 184 (194) T ss_pred CCCCCCEEECCCCCCCCCCCCCCCCCCHHHHH T ss_conf 55550258624443546788666667888999 No 90 >cd01893 Miro1 Miro1 subfamily. Miro (mitochondrial Rho) proteins have tandem GTP-binding domains separated by a linker region containing putative calcium-binding EF hand motifs. Genes encoding Miro-like proteins were found in several eukaryotic organisms. This CD represents the N-terminal GTPase domain of Miro proteins. These atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. Most Rho proteins contain a lipid modification site at the C-terminus; however, Miro is one of few Rho subfamilies that lack this feature. Probab=96.72 E-value=0.025 Score=33.01 Aligned_columns=153 Identities=14% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+-.+...+ .... .||....+-++. ++...+ ..+.+|=. .|...+..+. T Consensus 3 ivliGd~~VGKTsL~~rf~~~~-------F~~~--~~~t~~~~~~~~---~~~~~~-----v~l~iwDt-agqe~~~~~~ 64 (166) T cd01893 3 IVLIGDEGVGKSSLIMSLVSEE-------FPEN--VPRVLPEITIPA---DVTPER-----VPTTIVDT-SSRPQDRANL 64 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCE-------ECCC--CCCCEEEEEEEE---EECCCE-----EEEEEEEC-CCCCCCHHHH T ss_conf 8998079833889988875480-------0666--565103579989---971856-----89999872-5887505667 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.- -..++|+-|.+.+.+|-.=..+|+..+|..-. T Consensus 65 ~~~~~~----a~~~iivydi~~~~Sf~~i~~~W~~~i~~~~~-------------------------------------- 102 (166) T cd01893 65 AAEIRK----ANVICLVYSVDRPSTLERIRTKWLPLIRRLGV-------------------------------------- 102 (166) T ss_pred HHHHCC----CCEEEEEEECCCHHHHHHHHHHHHHHHHHHCC-------------------------------------- T ss_conf 876138----98899998648867878899887999975168-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCE--EEEECCCCCCCHHHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841--25521233210345655 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGAS--LIYTTPFLANSLQSLIH 286 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAs--LiYTS~~~~~nl~~Llh 286 (523) .+|+++|-+|+|..+ +.+-....+-+-.++-+|... -|.||.|...|.+.+-+ T Consensus 103 ----------------~~piilVGNK~DL~~---------~~~~~~~e~~~~~~~~~~~~i~~~~EtSAkt~~nV~e~F~ 157 (166) T cd01893 103 ----------------KVPIILVGNKSDLRD---------GSSQAGLEEEMLPIMNEFREIETCVECSAKTLINVSEVFY 157 (166) T ss_pred ----------------CCEEEEEECCCCCCC---------CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH T ss_conf ----------------957999715764223---------5421014789999999742775078875036888789999 No 91 >cd01870 RhoA_like RhoA-like subfamily. The RhoA subfamily consists of RhoA, RhoB, and RhoC. RhoA promotes the formation of stress fibers and focal adhesions, regulating cell shape, attachment, and motility. RhoA can bind to multiple effector proteins, thereby triggering different downstream responses. In many cell types, RhoA mediates local assembly of the contractile ring, which is necessary for cytokinesis. RhoA is vital for muscle contraction; in vascular smooth muscle cells, RhoA plays a key role in cell contraction, differentiation, migration, and proliferation. RhoA activities appear to be elaborately regulated in a time- and space-dependent manner to control cytoskeletal changes. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. RhoA and RhoC are observed only in geranyl Probab=96.70 E-value=0.042 Score=31.64 Aligned_columns=158 Identities=16% Q ss_pred EEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHH Q ss_conf 04788647798732123233111124556631225656744443342022331000677455110167871788711232 Q Fun_An_XP_0013 47 KNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAP 126 (523) Q Consensus 47 KnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~ 126 (523) +-|+++|+.+.||++|+..+....-.... .|.+...|-..+.+ ++...++.+|=- .|.-.|.. T Consensus 2 ~KiiliGd~~VGKTsli~r~~~~~F~~~~--------~pTi~~~~~~~i~i--------~~~~v~l~iwDt-aGqe~~~~ 64 (175) T cd01870 2 KKLVIVGDGACGKTCLLIVFSKDQFPEVY--------VPTVFENYVADIEV--------DGKQVELALWDT-AGQEDYDR 64 (175) T ss_pred EEEEEEECCCCCHHHHHHHHHCCCCCCCC--------CCEEEEEEEEEEEE--------CCEEEEEEEECC-CCHHHHHH T ss_conf 28899826984389999998638236652--------54022136899989--------896999987058-62024667 Q ss_pred HHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 00110581012003343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 127 LLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 127 LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) +-+.....-. .++|+-|-+.+.+|-.-...|+..+++.. + T Consensus 65 l~~~~~~~a~----~~ilvydi~~~~Sf~~i~~~W~~~~~~~~-----~------------------------------- 104 (175) T cd01870 65 LRPLSYPDTD----VILMCFSIDSPDSLENIPEKWTPEVKHFC-----P------------------------------- 104 (175) T ss_pred HHHHHHCCCC----EEEEEEECCCHHHHHHHHHHHHHHHHHHC-----C------------------------------- T ss_conf 7787504898----48999766865578999998899999725-----8------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCH------HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC-EEEEECCCCCC Q ss_conf 6453213688875326789507999618755------6788863588556899999999999987184-12552123321 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGADK------IEKLEKDHGWHEEQFDFILQFMRTLLLKHGA-SLIYTTPFLAN 279 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~------i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGA-sLiYTS~~~~~ 279 (523) .+|+++|-+|+|. +.-++++.... .-.+--+.++=++|+ .-|-||.+... T Consensus 105 ------------------~~piiLvgnK~DL~~~~~~~~~~~~~~~~~-----v~~~eg~~~a~~~~~~~y~E~SAktg~ 161 (175) T cd01870 105 ------------------NVPIILVGNKKDLRNDEHTRRELAKMKQEP-----VKPEEGRDMANKIGAFGYMECSAKTKE 161 (175) T ss_pred ------------------CCEEEEEECCCCCCCCHHHHHHHHHHCCCC-----CCHHHHHHHHHHCCCCEEEEEECCCCC T ss_conf ------------------952999851544334314677665410467-----798999999997399728987414888 Q ss_pred CHHHH Q ss_conf 03456 Q Fun_An_XP_0013 280 SLQSL 284 (523) Q Consensus 280 nl~~L 284 (523) |...+ T Consensus 162 nV~e~ 166 (175) T cd01870 162 GVREV 166 (175) T ss_pred CHHHH T ss_conf 87899 No 92 >cd04102 RabL3 RabL3 (Rab-like3) subfamily. RabL3s are novel proteins that have high sequence similarity with Rab family members, but display features that are distinct from Rabs, and have been termed Rab-like. As in other Rab-like proteins, RabL3 lacks a prenylation site at the C-terminus. The specific function of RabL3 remains unknown. Probab=96.68 E-value=0.01 Score=35.42 Aligned_columns=140 Identities=18% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+-|||+|+..+...+....- .+.-|- ...+-.+++.....++..-.+.+|=. .|.-.| T Consensus 3 IvliGDsgVGKTSLi~r~~~~~f~~~~--~~TIG~--------~v~~k~~~~~~~~~~~k~~~lqlWDT-AGQEry---- 67 (202) T cd04102 3 VLVVGDSGVGKSSLVHLICKNQVLGRP--SWTVGC--------SVDVKHHTYKEGTPEEKTFFVELWDV-GGSESV---- 67 (202) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCC--CCEEEE--------EEEEEEEEECCCCCCCEEEEEEEEEC-CCCHHH---- T ss_conf 899825985589998886537116885--751668--------99999998406776640799999853-897135---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) -.+.+.-++++ .|||+-|.+..-+| +.|++|+. |-..+.-.+.........-......+ T Consensus 68 -rsl~~~yYr~a~gvILVyDITnr~SF-enL~~Wl~-----------------Eil~k~~~~~~~~~~~~~~~~~~~~~- 127 (202) T cd04102 68 -KSTRAVFYNQVNGIILVHDLTNRKSS-QNLQRWSL-----------------EALNKDTFPTGLLVTNGDYDSEQFGG- 127 (202) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHH-HHHHHHHH-----------------HHHCCCCCCCCCCCCCCCCCHHHCCC- T ss_conf -66788885289879999757997899-99999999-----------------97414654445666555443012278- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHH Q ss_conf 45321368887532678950799961875567 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIE 239 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~ 239 (523) .-||++||-+|+|.+. T Consensus 128 ----------------~~ip~lvvGnK~D~~~ 143 (202) T cd04102 128 ----------------NQIPLLVIGTKLDQIP 143 (202) T ss_pred ----------------CCCEEEEECCCCCHHC T ss_conf ----------------9720899726400110 No 93 >cd00882 Ras_like_GTPase Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulate initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Memb Probab=96.51 E-value=0.042 Score=31.60 Aligned_columns=152 Identities=17% Q ss_pred EECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHH Q ss_conf 86477987321232331111245566312256567444433420223310006774551101678717887112320011 Q Fun_An_XP_0013 51 ILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLLKP 130 (523) Q Consensus 51 vLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LLk~ 130 (523) |+|..+.||++|+..+....... .... ..+..+....-...... .++.+|-+ .|...+.... T Consensus 1 ivG~~~~GKtsli~~~~~~~~~~----~~~~----------~~~~~~~~~~~~~~~~~-~~i~i~D~-~G~~~~~~~~-- 62 (157) T cd00882 1 VVGDSGVGKTSLLNRLLGGEFVP----EEYE----------TTIIDFYSKTIEVDGKK-VKLQIWDT-AGQERFRSLR-- 62 (157) T ss_pred CCCCCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEECCCCCEE-EEEEECCC-CCCHHHHHHH-- T ss_conf 90488888899999986481056----7456----------30578888742441114-68986157-8734466777-- Q ss_pred CCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC Q ss_conf 0581012003-343330000313689999999999999985069588899999999986226887677777677776645 Q Fun_An_XP_0013 131 LLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSAG 209 (523) Q Consensus 131 al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~~ 209 (523) +..++.+ .++++.|-+.+.++......|...+...... T Consensus 63 ---~~~~~~~~~~i~v~d~~~~~s~~~~~~~~~~~~~~~~~~-------------------------------------- 101 (157) T cd00882 63 ---RLYYRGADGIILVYDVTDRESFENVKEWLLLILINKEGE-------------------------------------- 101 (157) T ss_pred ---HHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCC-------------------------------------- T ss_conf ---886148988999972786000677899999999851589-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 32136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 210 PVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 210 ~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ++|++||++|+|.. +.+....++ ..+..+..+++..|.+|.+...+...+.. T Consensus 102 ---------------~~piiiv~nK~Dl~---~~~~~~~~~-------~~~~~~~~~~~~~~~~Sa~~~~~i~~~~~ 153 (157) T cd00882 102 ---------------NIPIILVGNKIDLP---EERVVSEEE-------LAEQLAKELGVPYFETSAKTGENVEELFE 153 (157) T ss_pred ---------------CCEEEEEECCCCHH---HHHHHHHHH-------HHHHHHHHCCCEEEEEECCCCCCHHHHHH T ss_conf ---------------97899981255802---444323378-------99999984598189986158978789999 No 94 >cd04165 GTPBP1_like GTPBP1-like. Mammalian GTP binding protein 1 (GTPBP1), GTPBP2, and nematode homologs AGP-1 and CGP-1 are GTPases whose specific functions remain unknown. In mouse, GTPBP1 is expressed in macrophages, in smooth muscle cells of various tissues and in some neurons of the cerebral cortex; GTPBP2 tissue distribution appears to overlap that of GTPBP1. In human leukemia and macrophage cell lines, expression of both GTPBP1 and GTPBP2 is enhanced by interferon-gamma (IFN-gamma). The chromosomal location of both genes has been identified in humans, with GTPBP1 located in chromosome 22q12-13.1 and GTPBP2 located in chromosome 6p21-12. Human glioblastoma multiforme (GBM), a highly-malignant astrocytic glioma and the most common cancer in the central nervous system, has been linked to chromosomal deletions and a translocation on chromosome 6. The GBM translocation results in a fusion of GTPBP2 and PTPRZ1, a protein involved in oligodendrocyte differentiation, recovery, and Probab=96.50 E-value=0.035 Score=32.11 Aligned_columns=178 Identities=20% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCC----------CCCCCCCCCCCCC--------CCCCCCEEEEEEEECCCCCCC Q ss_conf 4788647798732123233111124556----------6312256567444--------433420223310006774551 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSL----------SNDKRKGRVPPVA--------NQFALGYTYQDVLDADHEDTL 109 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~----------~~d~~kGr~ppia--------~~~~LgY~Y~dV~D~D~eD~~ 109 (523) .|.++|---+||+||+..|.....+..+ ..|...|+---|+ .+.-..|.+-.-.+.+.+.+- T Consensus 1 RV~v~GhVD~GKSTLlg~Lt~g~lD~GrG~ar~~l~kh~hE~~~G~Tssi~~~~lgf~~~g~~~n~~~~~~~~~~~~~~~ 80 (224) T cd04165 1 RVAVVGNVDAGKSTLLGVLTQGELDNGRGKARLNLFRHKHEVESGRTSSVSNEILGFDSDGEVVNYPDNHLSESDIEICE 80 (224) T ss_pred CEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEC T ss_conf 95889725776578999886322220001346666501467770641112234310011122002335654200000111 Q ss_pred CEEEEEEECCCCHHHHHHHHHCCCH--HHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH Q ss_conf 1016787178871123200110581--01200334333000031368999999999999998506958889999999998 Q Fun_An_XP_0013 110 ARVSAYLLSEPSLSFAPLLKPLLTP--QSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEW 187 (523) Q Consensus 110 aR~svyiL~d~d~~~~~LLk~al~~--~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~ 187 (523) .-.-+.++ ---|.|...+|-.+.- -+.+|-.++++---.-+ +.|=++-+.+++. T Consensus 81 ~~~k~itf-iD~pGHe~ylkt~i~G~~~~~~D~aiLvVaA~~G~---~~qT~EHl~l~~~-------------------- 136 (224) T cd04165 81 KSSKLVTF-IDLAGHERYLKTTLFGLTGYAPDYAMLVVAANAGI---IGMTKEHLGLALA-------------------- 136 (224) T ss_pred CCCCEEEE-EECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCC---HHHHHHHHHHHHH-------------------- T ss_conf 68837999-85765089999999887630105699998458995---4789999999998-------------------- Q ss_pred HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC Q ss_conf 62268876777776777766453213688875326789507999618755678886358855689999999999998718 Q Fun_An_XP_0013 188 RDRKRGMDSSSGGAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHG 267 (523) Q Consensus 188 ~e~~~~~~~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYG 267 (523) ||||++||+||.|.+. ++.++-+..-|.+++=+-| T Consensus 137 ------------------------------------l~ip~iVvvtKiDlv~---------~~~~~~~~~~i~~~lk~~~ 171 (224) T cd04165 137 ------------------------------------LNIPVFVVVTKIDLAP---------ANILQETLKDLKRILKVPG 171 (224) T ss_pred ------------------------------------HCCCEEEEECCCCCCC---------HHHHHHHHHHHHHHHHHHC T ss_conf ------------------------------------0898999971466689---------8999999999999987402 Q ss_pred --------------------------CEEEEECCCCCCCHHHHHHHHCCCCCCCCC Q ss_conf --------------------------412552123321034565532253224667 Q Fun_An_XP_0013 268 --------------------------ASLIYTTPFLANSLQSLIHSSLGIHSLLKR 297 (523) Q Consensus 268 --------------------------AsLiYTS~~~~~nl~~Llh~~lgih~ll~~ 297 (523) .-+|.||..--.++ .++|.. +..|+.| T Consensus 172 ~~~~p~~v~~~~d~v~~a~~~~~~~~vPIf~vS~vtG~gi-~~L~~f--L~~LP~r 224 (224) T cd04165 172 VRKLPVPVKSDDDVVLAASNFSSERIVPIFQVSNVTGEGL-DLLHAF--LNLLPLR 224 (224) T ss_pred CCCCCEECCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCH-HHHHHH--HHHCCCC T ss_conf 3224300156567899875077666013788506767887-999999--9727899 No 95 >cd04135 Tc10 TC10 subfamily. TC10 is a Rho family protein that has been shown to induce microspike formation and neurite outgrowth in vitro. Its expression changes dramatically after peripheral nerve injury, suggesting an important role in promoting axonal outgrowth and regeneration. TC10 regulates translocation of insulin-stimulated GLUT4 in adipocytes and has also been shown to bind directly to Golgi COPI coat proteins. GTP-bound TC10 in vitro can bind numerous potential effectors. Depending on its subcellular localization and distinct functional domains, TC10 can differentially regulate two types of filamentous actin in adipocytes. TC10 mRNAs are highly expressed in three types of mouse muscle tissues: leg skeletal muscle, cardiac muscle, and uterus; they were also present in brain, with higher levels in adults than in newborns. TC10 has also been shown to play a role in regulating the expression of cystic fibrosis transmembrane conductance regulator (CFTR) through interacti Probab=96.48 E-value=0.025 Score=33.04 Aligned_columns=161 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+-.+....-...- .|.|...+.... ..++....+.+|=- .|...|..+. T Consensus 3 ivliGd~~VGKTsLi~~~~~~~F~~~~--------~~Ti~~~~~~~i--------~i~~~~~~l~iwDt-aGqe~~~~~~ 65 (174) T cd04135 3 CVVVGDGAVGKTCLLMSYANDAFPEEY--------VPTVFDHYAVSV--------TVGGKQYLLGLYDT-AGQEDYDRLR 65 (174) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCC--------CCEEEECCCCEE--------EECCEEEEEEEECC-CCCHHHHHHH T ss_conf 899707984389999987618316764--------551440332003--------56886899987168-8870267788 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +....--. .++|+-|.+++.+|-.=-..|+..++.+.. T Consensus 66 ~~~~~~a~----~~ilvydit~~~Sf~~i~~~w~~~~~~~~~-------------------------------------- 103 (174) T cd04135 66 PLSYPMTD----VFLICFSVVNPASFQNVKEEWVPELKEYAP-------------------------------------- 103 (174) T ss_pred HHHCCCCC----EEEEEEECCCHHHHHHHHHHHHHHHHHHCC-------------------------------------- T ss_conf 97548998----799996558632489999998999986179-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHH-HHHHHHHHHHHCC-EEEEECCCCCCCHHHH Q ss_conf 53213688875326789507999618755678886358855689999-9999999987184-1255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFI-LQFMRTLLLKHGA-SLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfI-qQ~lRt~cLqYGA-sLiYTS~~~~~nl~~L 284 (523) .+|+++|-+|+|..+-..-...-.+...--| .+--+.++-++|+ .-|=||.+...|...+ T Consensus 104 ----------------~~piilVGnK~DL~~~~~~~~~~~~~~~r~Vs~eeg~~~a~~~~~~~f~EtSAkt~~~V~e~ 165 (174) T cd04135 104 ----------------NVPYLLVGTQIDLRDDPKTLARLNDMKEKPVTVEQGQKLAKEIGAHCYVECSALTQKGLKTV 165 (174) T ss_pred ----------------CCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHH T ss_conf ----------------95489973563331214677665420267789899999999808924688741467777899 No 96 >cd04142 RRP22 RRP22 subfamily. RRP22 (Ras-related protein on chromosome 22) subfamily consists of proteins that inhibit cell growth and promote caspase-independent cell death. Unlike most Ras proteins, RRP22 is down-regulated in many human tumor cells due to promoter methylation. RRP22 localizes to the nucleolus in a GTP-dependent manner, suggesting a novel function in modulating transport of nucleolar components. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Like most Ras family proteins, RRP22 is farnesylated. Probab=96.45 E-value=0.096 Score=29.42 Aligned_columns=165 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHH--HHH Q ss_conf 788647798732123233111124556631225656744443342022331000677455110167871788711--232 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLS--FAP 126 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~--~~~ 126 (523) |++||..+.||++|+-..-...-...- .|.|+..| |...-+.|.. ...+.+|=-+.-..+ .++ T Consensus 3 VvilGd~gVGKTsli~Rf~~~~F~~~y--------~pTig~~~---~~k~i~vdg~----~~~L~IwDt~~~~~~~~tag 67 (198) T cd04142 3 VAVLGAPGVGKTAIVRQFLAQEFPEEY--------IPTEHRRL---YRPAVVLSGR----VYDLHILDVPNMQRYPGTAG 67 (198) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCC--------CCCCCEEE---EEEEEEECCE----EEEEEEEECCCCCCCCCCCC T ss_conf 899818984189999887617437763--------56421014---6878989897----99999841443111456553 Q ss_pred HHHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC Q ss_conf 00110581012003-34333000031368999999999999998506958889999999998622688767777767777 Q Fun_An_XP_0013 127 LLKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFT 205 (523) Q Consensus 127 LLk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~ 205 (523) ---+.+-..+++++ .++||-|-+.+=+| +.+..|...+++.-.....+ T Consensus 68 qE~~~~r~r~lr~ad~~ilVydIt~~~SF-~~v~~~~~~i~~~~~~~~~~------------------------------ 116 (198) T cd04142 68 QEWMDPRFRGLRNSRAFILVYDICSPDSF-HYVKLLRQQILETRPAGNKE------------------------------ 116 (198) T ss_pred HHHHHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCCCCCC------------------------------ T ss_conf 01111222101278679999867996688-99999999999851358999------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHH Q ss_conf 66453213688875326789507999618755678886358855689999999999998718412552123321034565 Q Fun_An_XP_0013 206 SSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLI 285 (523) Q Consensus 206 ~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Ll 285 (523) +||++|-.||| |++++--..|. .++.-++ .|+..-|=||+|...|...|- T Consensus 117 --------------------~pivLVGNK~D----L~~~R~v~~e~---~~~~a~~---~~~~~f~EtSAK~~~NV~elF 166 (198) T cd04142 117 --------------------PPIVVVGNKRD----QQRHRFAPRHV---LSVLVRK---SWKCGYLECSAKYNWHILLLF 166 (198) T ss_pred --------------------CEEEEEECCCC----CCCCCCCCHHH---HHHHHHH---HCCCCEEEEECCCCCCHHHHH T ss_conf --------------------67999824765----21155267899---9999998---279737998613798888999 Q ss_pred HHHC Q ss_conf 5322 Q Fun_An_XP_0013 286 HSSL 289 (523) Q Consensus 286 h~~l 289 (523) +..+ T Consensus 167 ~~lv 170 (198) T cd04142 167 KELL 170 (198) T ss_pred HHHH T ss_conf 9999 No 97 >cd04126 Rab20 Rab20 subfamily. Rab20 is one of several Rab proteins that appear to be restricted in expression to the apical domain of murine polarized epithelial cells. It is expressed on the apical side of polarized kidney tubule and intestinal epithelial cells, and in non-polarized cells. It also localizes to vesico-tubular structures below the apical brush border of renal proximal tubule cells and in the apical region of duodenal epithelial cells. Rab20 has also been shown to colocalize with vacuolar H+-ATPases (V-ATPases) in mouse kidney cells, suggesting a role in the regulation of V-ATPase traffic in specific portions of the nephron. It was also shown to be one of several proteins whose expression is upregulated in human myelodysplastic syndrome (MDS) patients. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bo Probab=96.30 E-value=0.044 Score=31.50 Aligned_columns=156 Identities=21% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |++||..+-||++|+-... .|.++.-....+..|...+... ..+.+|=. -|.-.| T Consensus 3 ivliGd~~VGKTsLi~r~~-------------~~~F~~~~~Tig~~~~~k~~~~-------~~l~IWDT-AGqE~f---- 57 (220) T cd04126 3 VVLLGDMNVGKTSLLHRYM-------------ERRFKDTVSTVGGAFYLKQWGP-------YNISIWDT-AGREQF---- 57 (220) T ss_pred EEEEECCCCCHHHHHHHHH-------------CCEECCCCCCEEEEEEEEEEEE-------EEEEEEEC-CCCHHH---- T ss_conf 8998079832899988876-------------3710575462235688872247-------99999754-762354---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..+++. .+||+-|-+.+-+| ++|+.|..-+++.... T Consensus 58 -~~l~~~yyr~a~~~ilVyDit~~~SF-~~i~~~~~~~~~~~~~------------------------------------ 99 (220) T cd04126 58 -HGLGSMYCRGAAAVILTYDVSNVQSL-EELEDRFLGLTDTANE------------------------------------ 99 (220) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -56778650589789999766997788-9999999999983499------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHH--------HHHHHCCCCHHHHHHHHHHHHHHHHHHCCE---------- Q ss_conf 45321368887532678950799961875567--------888635885568999999999999871841---------- Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIE--------KLEKDHGWHEEQFDFILQFMRTLLLKHGAS---------- 269 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~--------~LEKe~dykdE~fDfIqQ~lRt~cLqYGAs---------- 269 (523) -+|+++|-.|||..+ ..++.+-..+.+-..=.+-.+.+|-+++.- T Consensus 100 -----------------~~~iilvGNK~DL~~~~~~~~~~~~~~~~~~~e~~r~V~~ee~~~~a~~~~~~~~~~~~~~~~ 162 (220) T cd04126 100 -----------------DCLFAVVGNKLDLTEEGALAGQEKDAGDRVSPEDQRQVTLEDAKAFYKRINKYKMLDEDLSPA 162 (220) T ss_pred -----------------CCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHC T ss_conf -----------------958999714634222221122221111112310004567899999999852210000000010 Q ss_pred ----EEEECCCCCCCHHHH Q ss_conf ----255212332103456 Q Fun_An_XP_0013 270 ----LIYTTPFLANSLQSL 284 (523) Q Consensus 270 ----LiYTS~~~~~nl~~L 284 (523) .|.||.|...|...+ T Consensus 163 ~~~~y~EtSAKtg~nV~e~ 181 (220) T cd04126 163 AEKMCFETSAKTGYNVDEL 181 (220) T ss_pred CCCCEEEEECCCCCCHHHH T ss_conf 3753689751578788899 No 98 >cd04162 Arl9_Arfrp2_like Arl9/Arfrp2-like subfamily. Arl9 (Arf-like 9) was first identified as part of the Human Cancer Genome Project. It maps to chromosome 4q12 and is sometimes referred to as Arfrp2 (Arf-related protein 2). This is a novel subfamily identified in human cancers that is uncharacterized to date. Probab=96.27 E-value=0.016 Score=34.15 Aligned_columns=107 Identities=22% Q ss_pred EEEECCCCCCCEEHHHHHHCCC-CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 7886477987321232331111-245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADS-SDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~-~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) ||+||-++.|||||+-.+.+.. .....|.. |....-++..+ .++.+|=+ .|...+..+ T Consensus 2 IliLGLd~aGKTtil~~l~~~~~~~~~~PTi-------------Gfn~~~i~~~~-------~~l~~wDi-gGq~~~R~~ 60 (164) T cd04162 2 ILVLGLDGAGKTSLLHSLSSERSLESVVPTT-------------GFNSVAIPTQD-------AIMELLEI-GGSQNLRKY 60 (164) T ss_pred EEEEEECCCCHHHHHHHHHCCCCCCCEEEEE-------------EEEEEEEEECC-------EEEEEEEC-CCCCCCHHH T ss_conf 7899747975788777672796246266445-------------10589987187-------89999874-786200134 Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 0110581012003-343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) -+.. +.++ .+|+|+|-+++-.+ .+.++..++++. T Consensus 61 W~~Y-----y~~~~giIfVVDssD~~rl-------------------~eak~eL~~ll~--------------------- 95 (164) T cd04162 61 WKRY-----LSGSQGLIFVVDSADSERL-------------------PLARQELHQLLQ--------------------- 95 (164) T ss_pred HHHH-----CCCCCEEEEEEECCCHHHH-------------------HHHHHHHHHHHH--------------------- T ss_conf 6764-----1678789999856881118-------------------999999999983--------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCC Q ss_conf 645321368887532678950799961875 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGAD 236 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD 236 (523) +.-++|++|++.|+| T Consensus 96 ---------------~~~~~PllvlaNKqD 110 (164) T cd04162 96 ---------------HPPDLPLVVLANKQD 110 (164) T ss_pred ---------------CCCCCEEEEEECCCC T ss_conf ---------------579971899841548 No 99 >cd00879 Sar1 Sar1 subfamily. Sar1 is an essential component of COPII vesicle coats involved in export of cargo from the ER. The GTPase activity of Sar1 functions as a molecular switch to control protein-protein and protein-lipid interactions that direct vesicle budding from the ER. Activation of the GDP to the GTP-bound form of Sar1 involves the membrane-associated guanine nucleotide exchange factor (GEF) Sec12. Sar1 is unlike all Ras superfamily GTPases that use either myristoyl or prenyl groups to direct membrane association and function, in that Sar1 lacks such modification. Instead, Sar1 contains a unique nine-amino-acid N-terminal extension. This extension contains an evolutionarily conserved cluster of bulky hydrophobic amino acids, referred to as the Sar1-N-terminal activation recruitment (STAR) motif. The STAR motif mediates the recruitment of Sar1 to ER membranes and facilitates its interaction with mammalian Sec12 GEF leading to activation. Probab=96.23 E-value=0.012 Score=34.97 Aligned_columns=121 Identities=21% Q ss_pred CEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHH Q ss_conf 20478864779873212323311112455663122565674444334202233100067745511016787178871123 Q Fun_An_XP_0013 46 EKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFA 125 (523) Q Consensus 46 sKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~ 125 (523) +-.||+||-+++||||+|..|.........|.. |.-...+.+.+ .++.+|=+ .|...+- T Consensus 19 e~kIlilGLd~aGKTTil~~l~~~~~~~~~PTi-------------G~n~e~i~~~~-------~~~~iwDi-gGq~~~R 77 (190) T cd00879 19 EAKILFLGLDNAGKTTLLHMLKDDRLAQHVPTL-------------HPTSEELTIGN-------IKFKTFDL-GGHEQAR 77 (190) T ss_pred CEEEEEEEECCCCHHHHHHHHHCCCEEEEECCC-------------CCEEEEEEECC-------EEEEEEEC-CCCCCCH T ss_conf 338999965798789988887269634652000-------------35178988778-------89999874-7986342 Q ss_pred HHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC Q ss_conf 20011058101200334333000031368999999999999998506958889999999998622688767777767777 Q Fun_An_XP_0013 126 PLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFT 205 (523) Q Consensus 126 ~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~ 205 (523) ++-+.-.. .-..||+|+|-|++=.+-+.-...-.+|+ ++.+. T Consensus 78 ~~W~~Yy~----~~~giIfVVDssD~~r~~eak~eL~~lL~--------------~~~l~-------------------- 119 (190) T cd00879 78 RLWKDYFP----EVDGIVFLVDAADPERFQESKEELDSLLS--------------DEELA-------------------- 119 (190) T ss_pred HHHHHHCC----CCCEEEEEEECCCCCCHHHHHHHHHHHHC--------------CCCCC-------------------- T ss_conf 46775414----63189999863786547889999999843--------------30107-------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHH Q ss_conf 664532136888753267895079996187556788863 Q Fun_An_XP_0013 206 SSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKD 244 (523) Q Consensus 206 ~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe 244 (523) ++|++|++.|+|.-..+..+ T Consensus 120 -------------------~~PiLIlaNKqDl~~a~~~~ 139 (190) T cd00879 120 -------------------NVPFLILGNKIDLPGAVSEE 139 (190) T ss_pred -------------------CCEEEEEEECCCCCCCCCHH T ss_conf -------------------97489984055887587989 No 100 >cd01896 DRG The developmentally regulated GTP-binding protein (DRG) subfamily is an uncharacterized member of the Obg family, an evolutionary branch of GTPase superfamily proteins. GTPases act as molecular switches regulating diverse cellular processes. DRG2 and DRG1 comprise the DRG subfamily in eukaryotes. In view of their widespread expression in various tissues and high conservation among distantly related species in eukaryotes and archaea, DRG proteins may regulate fundamental cellular processes. It is proposed that the DRG subfamily proteins play their physiological roles through RNA binding. Probab=96.20 E-value=0.029 Score=32.62 Aligned_columns=202 Identities=18% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) +|.+.|-...||.|||..|++......--.....-.+|-+-+..+--..+.|.-- +-++.....++ T Consensus 2 ~V~lvG~pNvGKSTLln~Lt~~~~~v~~~pftT~~p~~g~~~~~~~~i~lvDtPG--------------ii~~~~~~~~~ 67 (233) T cd01896 2 RVALVGFPSVGKSTLLSKLTNTKSEVAAYEFTTLTCVPGVLEYKGAKIQLLDLPG--------------IIEGAADGKGR 67 (233) T ss_pred CEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCEEEEEEECCC--------------CCCCCCCCHHH T ss_conf 1888747998689999998628852236787652202558987786899984587--------------66661013025 Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC-------------------------HHHHHH Q ss_conf 0110581012003-34333000031368999999999999998506958-------------------------889999 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDE-------------------------TKIVME 181 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e-------------------------~~~~me 181 (523) -+-+|. .++++ ++++|+|-++||. +...+.+-|...=..|+.+ ..+..+ T Consensus 68 ~~~~l~--~ir~aD~il~vvD~~~~~~---~~~~l~~eL~~~gI~L~k~~~~v~i~k~~~gGi~i~~~~~~~~~d~~~i~ 142 (233) T cd01896 68 GRQVIA--VARTADLILMVLDATKPEG---HREILERELEGVGIRLNKRPPNITIKKKKKGGINITSTVPLTKLDEKTIK 142 (233) T ss_pred HHHHHH--HHHHCCEEEEEEECCCCHH---HHHHHHHHHHHCCEEECCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHH T ss_conf 899999--9863888999986799878---99999999985680525768835899833567787234676558989999 Q ss_pred HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC-CEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHH Q ss_conf 999998622688767777767777664532136888753267895-0799961875567888635885568999999999 Q Fun_An_XP_0013 182 ENLTEWRDRKRGMDSSSGGAQGFTSSAGPVTIPLGPGEWDEGLGI-PMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMR 260 (523) Q Consensus 182 e~~~~~~e~~~~~~~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGi-Pi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lR 260 (523) .++.+|.=|. +.-...+++.+--=...+..|... |+++|+.|+|.++.-|.+ T Consensus 143 ~il~e~~i~~-----------a~v~i~~~vt~d~~id~l~~~~~y~P~i~V~NKiDl~~~e~~~---------------- 195 (233) T cd01896 143 AILREYKIHN-----------ADVLIREDITVDDLIDVIEGNRVYIPCLYVYNKIDLISIEELD---------------- 195 (233) T ss_pred HHHHHCCCCC-----------EEEEECCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHH---------------- T ss_conf 9998628443-----------0589705888788988873364100389998136788845688---------------- Q ss_pred HHHHHHCCEEEEECCCCCCCHHHH---HHHHCCCCCCCCC Q ss_conf 999871841255212332103456---5532253224667 Q Fun_An_XP_0013 261 TLLLKHGASLIYTTPFLANSLQSL---IHSSLGIHSLLKR 297 (523) Q Consensus 261 t~cLqYGAsLiYTS~~~~~nl~~L---lh~~lgih~ll~~ 297 (523) -|.-..-.+..|.....++..| ++++|++-+.|.+ T Consensus 196 --~l~~~~~~i~ISA~~g~gld~Lke~I~~~L~~iRVYtK 233 (233) T cd01896 196 --LLARQPNSVVISAEKGLNLDELKERIWDKLGLIRVYTK 233 (233) T ss_pred --HHHHCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEECC T ss_conf --87625881899833688978999999877290786419 Done!