HumanPRENbase
Database of Prenylated Human
Proteins and their Orthologues
Protein CaaX Farnesylation, CaaX Geranylgeranylation and Rab Geranylgeranylation

CLUSTER parameter selection

REQUIRE one of the features for at least one member of listed clusters:
Status-KNOWN Status-LIKELY Status-NEW FT-substrate(s) GGT1-substrate(s)
EXCLUDE clusters with the following features for at least one member:
Status-OUT-OF-CONTEXT
Other features for cluster members are ALLOWED.
Minimum cluster-size: 1

SEQUENCE parameter selection

INCLUDE entries with the following features:
Viruses Mammalia Aves Amphibia Fishes Insecta Nematoda Fungi Plants Other-Eukaryota
EXCLUDE entries with the following features:
Synthetic-constructs
Ranked by evOluation of cluster after selection

Querycode: Hcs2220ce221ct11111111111111cm1se111st00202222222221r3 (save for easy recovery of the identical query parameters)
 Clusters  Selected Sequences
General Information Stats Stats Enzyme Taxonomic Kingdom Taxonomic Detail Eukaryota
Status Rank ClustID Name Pren Total PC EvO Number PC EvO FT GGT1 GGT2 Viruses Synthetic Eukaryota Mammalia Birds Amphibia Fishes Insecta Nematoda Fungi Plants Other
+ 1 13569962
(4 isoinpas)		 RAB1B, member RAS oncogene family 68 72 42.750 64.222 67
Explore		 42.000 62.347 11 1 67 0 0 67 5 1 2 1 5 2 19 17 15
+ 2 4557920
(5 isoinpas)		 CDC42 - cell division cycle 42 GTP-binding protein, 25kD 44 52 26.000 37.231 44
Explore		 26.000 37.231 44 43 0 0 0 44 4 1 1 2 3 5 24 0 4
+ 3 15826631
(6 isoinpas)		 RAC1 - RAS-related C3 botulinum toxin substrate 1 42 52 26.000 33.923 42
Explore		 26.000 33.923 40 38 0 0 0 42 3 0 1 2 2 1 13 14 6
+ 4 54697048
(5 isoinpas)		 RAP1B, member of RAS oncogene family 30 31 15.333 29.032 30
Explore		 15.333 29.032 29 29 0 0 0 30 4 1 1 4 3 1 9 0 7
+ 5 55670772
(5 isoinpas)		 RhoA - Rho-related GTP-binding protein 34 40 20.000 28.900 34
Explore		 20.000 28.900 33 34 0 0 0 34 4 1 1 2 3 1 18 0 4
+ 6 15718763
(5 isoinpas)		 K-Ras, Kirsten rat sarcoma-2 viral v-Ki-ras2 oncogene homolog 32 38 17.250 26.947 32
Explore		 17.250 26.947 32 29 0 2 0 30 6 1 3 8 1 2 4 0 5
+ 7 42490908
(3 isoinpas)		 RHEB - Ras homolog enriched in brain 25 28 16.000 22.321 25
Explore		 16.000 22.321 25 18 0 0 0 25 4 1 1 1 3 2 12 0 1
* 8 10880989
(no isoinpas)		 RAB18 long isoform, member RAS oncogene family 22 22 15.750 22.000 22
Explore		 15.750 22.000 8 4 22 0 0 22 3 1 2 2 4 2 1 4 3
+ 9 5730120
(3 isoinpas)		 SNARE protein Ykt6 28 41 13.500 19.122 28
Explore		 13.500 19.122 28 24 0 0 0 28 3 0 2 1 0 0 14 4 4
+ 10 4885425
(2 isoinpas)		 H-Ras, v-Ha-ras Harvey rat sarcoma viral oncogene homolog 21 24 11.250 18.375 21
Explore		 11.250 18.375 20 6 0 5 0 16 5 1 1 1 1 1 2 0 4
+ 11 7706563
(no isoinpas)		 RAB8B, member RAS oncogene family 18 20 9.917 16.200 18
Explore		 9.917 16.200 7 7 18 0 0 18 3 0 1 1 0 2 8 1 2
* 12 234746
(no isoinpas)		 RAS-related protein MEL 15 15 4.667 15.000 15
Explore		 4.667 15.000 2 2 15 0 0 15 2 0 0 0 0 0 5 6 2
? 13 6330169
(no isoinpas)		 DUF544, KIAA1164 protein 17 20 7.083 14.450 17
Explore		 7.083 14.450 17 13 0 0 0 17 3 1 0 0 0 1 11 0 1
+ 14 37595069
(no isoinpas)		 N-Ras, neuroblastoma RAS viral oncogene homolog 13 14 6.000 12.071 13
Explore		 6.000 12.071 13 8 0 0 0 13 6 1 1 1 0 0 3 0 1
+ 15 7706359
(3 isoinpas)		 DEXRAS1, dexamethasone-induced RAS 1, RASD1 12 12 6.000 12.000 12
Explore		 6.000 12.000 12 2 0 0 0 12 4 1 1 2 3 1 0 0 0
+ 16 15126742
(2 isoinpas)		 Lamin B1 13 15 7.583 11.267 13
Explore		 7.583 11.267 13 13 0 0 0 13 3 1 2 1 1 2 0 0 3
+ 17 4506339
(2 isoinpas)		 peroxisomal biogenesis factor 19 17 28 9.333 10.321 17
Explore		 9.333 10.321 17 13 0 0 0 17 6 0 1 1 1 2 5 1 0
? 18 55777304
(3 isoinpas)		 Ubiquitin-like 3 12 14 8.000 10.286 12
Explore		 8.000 10.286 12 10 0 0 0 12 3 1 1 1 2 2 1 1 0
* 19 7706567
(2 isoinpas)		 guanine nucleotide binding protein G protein, gamma 13 12 14 5.000 10.286 12
Explore		 5.000 10.286 12 12 0 0 0 12 4 1 2 2 3 0 0 0 0
* 20 4506405
(2 isoinpas)		 RALB - v-ral simian leukemia viral oncogene homolog B; v-ral simian leukemia viral oncogene homolog B 12 13 4.167 11.077 11
Explore		 3.750 9.308 11 11 0 0 0 11 5 1 1 2 0 0 0 0 2
+ 21 20147713
(2 isoinpas)		 RALA, Ras family small GTP binding protein 11 13 5.500 9.308 11
Explore		 5.500 9.308 11 11 0 0 0 11 2 1 1 2 3 2 0 0 0
? 22 7243161
(3 isoinpas)		 DUF544 10 11 4.167 9.091 10
Explore		 4.167 9.091 10 9 0 0 0 10 5 0 1 0 0 1 1 2 0
* 23 32698769
(no isoinpas)		 guanine nucleotide binding protein G protein, gamma 7 9 9 2.917 9.000 9
Explore		 2.917 9.000 9 9 0 0 0 9 4 0 1 2 1 1 0 0 0
* 24 6841496
(3 isoinpas)		 RAB23, member RAS oncogene family 12 16 6.000 9.000 12
Explore		 6.000 9.000 10 6 11 0 0 12 4 1 1 1 3 0 0 0 2
* 25 31616611
(2 isoinpas)		 RAP2C, member RAS oncogene family 9 9 4.000 9.000 9
Explore		 4.000 9.000 9 2 0 0 0 9 2 1 1 3 1 1 0 0 0
+ 26 4456614
(6 isoinpas)		 PALM - paralemmin 9 9 2.333 9.000 9
Explore		 2.333 9.000 9 9 0 0 0 9 5 2 1 1 0 0 0 0 0
? 27 42822891
(no isoinpas)		 Selenoprotein W-related 9 9 3.000 9.000 9
Explore		 3.000 9.000 9 8 0 0 0 9 3 1 0 2 3 0 0 0 0
+ 28 38524620
(no isoinpas)		 prickle-like 2 10 12 4.167 8.333 10
Explore		 4.167 8.333 10 1 0 0 0 10 4 0 0 2 2 1 0 0 1
+ 29 13623559
(2 isoinpas)		 2',3'-cyclic nucleotide 3' phosphodiesterase 10 12 2.250 8.333 10
Explore		 2.250 8.333 10 9 0 0 0 10 6 0 2 2 0 0 0 0 0
+ 30 28200377
(3 isoinpas)		 DnaJA2 - DnaJ/Hsp40 homolog, subfamily A, member 2 14 24 8.167 8.167 14
Explore		 8.167 8.167 13 1 0 0 0 14 3 1 2 1 0 2 0 1 4
+ 31 10518344
(no isoinpas)		 RAP2A, member RAS oncogene family 10 10 3.750 10.000 9
Explore		 3.750 8.100 9 2 0 0 0 9 4 0 1 1 2 0 0 0 1
+ 32 4506381
(2 isoinpas)		 RAC2 - RAS-related C3 botulinum toxin substrate 2 9 10 3.333 8.100 9
Explore		 3.333 8.100 9 7 0 0 0 9 4 1 1 2 0 0 0 1 0
+ 33 1839517
(3 isoinpas)		 RhoE - Rho-related GTP-binding protein 9 10 3.000 8.100 9
Explore		 3.000 8.100 9 9 0 0 0 9 5 1 2 1 0 0 0 0 0
+ 34 51036603
(2 isoinpas)		 G-protein gamma-12 subunit 8 8 2.667 8.000 8
Explore		 2.667 8.000 8 8 0 0 0 8 3 0 1 0 3 1 0 0 0
+ 35 21748630
(2 isoinpas)		 protein phosphatase 1 regulatory subunit 16A 10 13 3.333 7.692 10
Explore		 3.333 7.692 10 8 0 0 0 10 5 0 0 1 2 2 0 0 0
? 36 21956647
(4 isoinpas)		 ubiquitin specific protease 32 9 11 2.667 7.364 9
Explore		 2.667 7.364 9 1 0 0 0 9 4 1 0 1 3 0 0 0 0
+ 37 1710024
(2 isoinpas)		 RAB28, member RAS oncogene family isoform 1 8 9 2.333 7.111 8
Explore		 2.333 7.111 8 1 0 0 0 8 5 1 0 1 0 0 0 0 1
+ 38 68950
(2 isoinpas)		 RAP2B, member RAS oncogene family 7 7 2.917 7.000 7
Explore		 2.917 7.000 7 7 0 0 0 7 2 0 1 2 0 1 0 0 1
+ 39 4585864
(2 isoinpas)		 phosphodiesterase 6A, alpha subunit 7 7 1.500 7.000 7
Explore		 1.500 7.000 7 1 0 0 0 7 5 0 1 1 0 0 0 0 0
* 40 54696976
(3 isoinpas)		 M-Ras, muscle RAS oncogene homolog, R-Ras3 9 12 3.750 6.750 9
Explore		 3.750 6.750 9 7 0 0 0 9 4 1 1 1 0 2 0 0 0
+ 41 7657514
(no isoinpas)		 Rho6/Rnd1 - Rho-related GTP-binding protein 7 8 1.750 6.125 7
Explore		 1.750 6.125 7 7 0 0 0 7 4 0 2 1 0 0 0 0 0
+ 42 54633194
(3 isoinpas)		 protein phosphatase 1, regulatory inhibitor subunit 16B 7 8 1.500 6.125 7
Explore		 1.500 6.125 7 1 0 0 0 7 5 1 0 0 1 0 0 0 0
+ 43 4505669
(4 isoinpas)		 phosphodiesterase 6B, cGMP-specific, rod, beta 7 8 1.750 6.125 7
Explore		 1.750 6.125 7 5 0 0 0 7 5 0 1 1 0 0 0 0 0
* 44 38016957
(2 isoinpas)		 RhoF - Rho-related GTP-binding protein 6 6 2.000 6.000 6
Explore		 2.000 6.000 6 6 0 0 0 6 3 1 1 1 0 0 0 0 0
* 45 33150588
(2 isoinpas)		 RhoJ - Rho-related GTP-binding protein 6 6 2.000 6.000 6
Explore		 2.000 6.000 6 3 0 0 0 6 3 1 1 1 0 0 0 0 0
+ 46 20147741
(no isoinpas)		 Ras family small GTP binding protein TC21 6 6 1.250 6.000 6
Explore		 1.250 6.000 6 4 0 0 0 6 1 0 0 0 2 0 3 0 0
? 47 12314158
(3 isoinpas)		 DUF1339, possibly integral membrane protein 11 21 4.583 5.762 11
Explore		 4.583 5.762 11 2 0 0 0 11 4 1 0 1 3 2 0 0 0
+ 48 21166359
(no isoinpas)		 G-protein-coupled receptor kinase 7 7 9 1.167 5.444 7
Explore		 1.167 5.444 7 7 0 0 0 7 4 0 0 3 0 0 0 0 0
+ 49 21707244
(9 isoinpas)		 guanylate binding proteins 1/2/5 9 15 2.667 5.400 9
Explore		 2.667 5.400 8 7 0 0 0 9 6 1 1 1 0 0 0 0 0
+ 50 30583721
(3 isoinpas)		 lamin B2 14 37 5.500 5.297 14
Explore		 5.500 5.297 14 12 0 0 0 14 3 1 2 2 1 0 0 0 5
+ 51 3406430
(4 isoinpas)		 hPRL-3 protein tyrosine phosphatase 6 7 1.500 5.143 6
Explore		 1.500 5.143 6 6 0 0 0 6 3 0 1 2 0 0 0 0 0
? 52 3417289
(3 isoinpas)		 C16orf45 homolog 6 7 1.500 5.143 6
Explore		 1.500 5.143 6 6 0 0 0 6 4 1 0 1 0 0 0 0 0
+ 53 39653934
(4 isoinpas)		 lamin A/progerin 12 28 4.167 5.143 12
Explore		 4.167 5.143 12 11 0 0 0 12 4 1 1 2 0 0 0 0 4
+ 54 16740917
(no isoinpas)		 G protein, gamma 10 5 5 1.250 5.000 5
Explore		 1.250 5.000 5 5 0 0 0 5 3 0 1 1 0 0 0 0 0
? 55 40788968
(3 isoinpas)		 KIAA0878 protein 5 5 0.833 5.000 5
Explore		 0.833 5.000 5 5 0 0 0 5 4 1 0 0 0 0 0 0 0
+ 56 21553323
(no isoinpas)		 Di-Ras1, small GTP-binding tumor suppressor 1, Rig 5 5 0.833 5.000 5
Explore		 0.833 5.000 5 5 0 0 0 5 3 0 0 2 0 0 0 0 0
+ 57 54695766
(no isoinpas)		 RhoC - Rho-related GTP-binding protein 7 10 2.333 4.900 7
Explore		 2.333 4.900 5 7 0 0 0 7 3 1 0 1 0 0 2 0 0
? 58 6164721
(7 isoinpas)		 F-box protein Fbl2 12 31 5.000 4.645 12
Explore		 5.000 4.645 12 12 0 0 0 12 5 1 0 2 0 1 3 0 0
* 59 1705960
(4 isoinpas)		 Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit 6 8 1.667 4.500 6
Explore		 1.667 4.500 6 3 0 0 0 6 3 1 1 1 0 0 0 0 0
+ 60 4506529
(no isoinpas)		 rhodopsin kinase 6 8 1.500 4.500 6
Explore		 1.500 4.500 6 1 0 0 0 6 4 1 0 1 0 0 0 0 0
* 61 36036
(3 isoinpas)		 RhoG - Rho-related GTP-binding protein 6 8 2.000 4.500 6
Explore		 2.000 4.500 6 6 0 0 0 6 2 1 1 2 0 0 0 0 0
* 62 15277321
(no isoinpas)		 RAS-like, family 10, member B 5 6 1.250 4.167 5
Explore		 1.250 4.167 5 5 0 0 0 5 3 0 1 1 0 0 0 0 0
* 63 54695756
(no isoinpas)		 RAC3 - RAS-related C3 botulinum toxin substrate 3 5 6 1.333 4.167 5
Explore		 1.333 4.167 5 5 0 0 0 5 2 1 0 1 0 0 0 0 1
* 64 23503303
(no isoinpas)		 conserved serine-threonine kinase 7 12 1.750 4.083 7
Explore		 1.750 4.083 7 7 0 0 0 7 4 0 0 0 2 1 0 0 0
* 65 5454030
(no isoinpas)		 RRP22, RAS-related on chromosome 22 4 4 0.333 4.000 4
Explore		 0.333 4.000 4 4 0 0 0 4 4 0 0 0 0 0 0 0 0
+ 66 31795561
(no isoinpas)		 complexin 4, binds to SNAP receptor complexes 4 4 1.000 4.000 4
Explore		 1.000 4.000 4 4 0 0 0 4 2 0 1 1 0 0 0 0 0
+ 67 49257311
(3 isoinpas)		 RAB13, member RAS oncogene family 7 10 1.750 4.900 6
Explore		 1.500 3.600 5 1 6 0 0 6 4 0 0 1 0 0 0 0 1
+ 68 37718739
(3 isoinpas)		 RhoB - Rho-related GTP-binding protein 5 7 1.667 3.571 5
Explore		 1.667 3.571 5 5 0 0 0 5 2 1 1 0 0 0 1 0 0
+ 69 4678722
(3 isoinpas)		 CLICK-III/CaMKIgamma - Calcium/calmodulin-dependent protein kinase type 1G 6 11 1.500 3.273 6
Explore		 1.500 3.273 6 6 0 0 0 6 4 1 0 1 0 0 0 0 0
? 70 13775218
(no isoinpas)		 cysteine-motif similar to RING finger 4 5 0.667 3.200 4
Explore		 0.667 3.200 4 4 0 0 0 4 3 1 0 0 0 0 0 0 0
* 71 5454028
(no isoinpas)		 R-Ras, related RAS viral r-ras oncogene homolog 4 5 0.333 3.200 4
Explore		 0.333 3.200 4 4 0 0 0 4 4 0 0 0 0 0 0 0 0
* 72 54695658
(no isoinpas)		 RhoN - Rho-related GTP-binding protein 4 5 0.667 3.200 4
Explore		 0.667 3.200 4 4 0 0 0 4 3 0 0 1 0 0 0 0 0
? 73 458692
(3 isoinpas)		 WD repeat domain 42A 7 16 2.000 3.062 7
Explore		 2.000 3.062 7 1 0 0 0 7 4 0 1 0 0 0 1 1 0
* 74 15147246
(no isoinpas)		 G protein, gamma 8 3 3 0.500 3.000 3
Explore		 0.500 3.000 3 3 0 0 0 3 2 0 0 1 0 0 0 0 0
+ 75 4758450
(no isoinpas)		 G protein, gamma 4 3 3 0.500 3.000 3
Explore		 0.500 3.000 3 3 0 0 0 3 2 0 1 0 0 0 0 0 0
+ 76 23503098
(3 isoinpas)		 X-linked retinitis pigmentosa GTPase regulator 6 12 0.250 3.000 6
Explore		 0.250 3.000 6 6 0 0 0 6 6 0 0 0 0 0 0 0 0
* 77 51474992
(no isoinpas)		 low complexity rich protein 3 3 0.250 3.000 3
Explore		 0.250 3.000 3 3 0 0 0 3 3 0 0 0 0 0 0 0 0
+ 78 18676540
(3 isoinpas)		 complexin 3, binds to SNAP receptor complexes 3 3 0.500 3.000 3
Explore		 0.500 3.000 3 3 0 0 0 3 2 0 0 1 0 0 0 0 0
? 79 34098968
(3 isoinpas)		 lysozyme-like 2 6 11 0.833 3.273 5
Explore		 0.833 2.273 4 1 0 0 0 5 4 0 0 0 1 0 0 0 0
? 80 55664133
(4 isoinpas)		 novel protein 3 4 0.250 2.250 3
Explore		 0.250 2.250 3 3 0 0 0 3 3 0 0 0 0 0 0 0 0
? 81 51458801
(no isoinpas)		 TPR containing protein 3 4 0.250 2.250 3
Explore		 0.250 2.250 3 1 0 0 0 3 3 0 0 0 0 0 0 0 0
? 82 51468012
(2 isoinpas)		 PREDICTED: hypothetical protein XP_498436 2 2 0.167 2.000 2
Explore		 0.167 2.000 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0
? 83 51471395
(no isoinpas)		 C-terminal variation of peptidyl-prolyl cis-trans isomerase A 2 2 0.167 2.000 2
Explore		 0.167 2.000 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0
? 84 27734755
(no isoinpas)		 F-box and leucine-rich repeat protein 20 6 26 2.083 1.385 6
Explore		 2.083 1.385 6 6 0 0 0 6 2 0 1 1 1 1 0 0 0
+ 85 4758448
(no isoinpas)		 G protein, gamma 11 2 3 0.333 1.333 2
Explore		 0.333 1.333 2 1 0 0 0 2 1 0 0 0 0 0 0 0 1
* 86 55661671
(no isoinpas)		 RAB18 short isoform, member RAS oncogene family 2 3 0.167 1.333 2
Explore		 0.167 1.333 2 2 1 0 0 2 2 0 0 0 0 0 0 0 0
? 87 7705708
(2 isoinpas)		 fls485, weak similarity to DnaJ chaperone 3 8 0.500 1.125 3
Explore		 0.500 1.125 2 1 0 0 0 3 2 0 1 0 0 0 0 0 0
? 88 37182292
(no isoinpas)		 WLPL514 1 1 0.083 1.000 1
Explore		 0.083 1.000 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 89 51467487
(no isoinpas)		 F-box protein 10 3 9 0.500 1.000 3
Explore		 0.500 1.000 3 3 0 0 0 3 2 0 0 1 0 0 0 0 0
* 90 55859596
(4 isoinpas)		 PALM2, paralemmin 2, A kinase anchor protein 2 2 5 0.167 0.800 2
Explore		 0.167 0.800 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0
? 91 4505235
(2 isoinpas)		 mannose-6-phosphate isomerase 7 86 1.750 0.570 7
Explore		 1.750 0.570 7 7 0 0 0 7 5 1 0 1 0 0 0 0 0
? 92 51467591
(no isoinpas)		 PREDICTED: hypothetical protein XP_499158 1 2 0.083 0.500 1
Explore		 0.083 0.500 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 93 8051621
(2 isoinpas)		 2',5'-oligoadenylate synthetase 1 isoform E18 2 10 0.167 0.400 2
Explore		 0.167 0.400 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0
+ 94 21361097
(no isoinpas)		 guanine nucleotide binding protein G protein, gamma 10 2 11 0.167 0.364 2
Explore		 0.167 0.364 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0
? 95 21750201
(no isoinpas)		 similar to C-terminus of Cat eye syndrome critical region protein 2 involved in cytoskeletal organisation 1 4 0.083 0.250 1
Explore		 0.083 0.250 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 96 55665766
(2 isoinpas)		 heparanase 2, glycosyl hydrolase family 79 N-terminal domain 1 5 0.083 0.200 1
Explore		 0.083 0.200 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 97 51476045
(no isoinpas)		 weak similarity to carbonic anhydrase 1 5 0.083 0.200 1
Explore		 0.083 0.200 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 98 40353014
(no isoinpas)		 Chondroitin N-acetylgalactosaminyltransferase 1 7 0.083 0.143 1
Explore		 0.083 0.143 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 99 15559717
(no isoinpas)		 Adaptin 1 9 0.083 0.111 1
Explore		 0.083 0.111 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 100 23065557
(no isoinpas)		 glutathione S-transferase M4 isoform 2 1 18 0.083 0.056 1
Explore		 0.083 0.056 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 101 28178838
(2 isoinpas)		 isocitrate dehydrogenase 3 NAD+ gamma isoform b precursor 1 18 0.083 0.056 1
Explore		 0.083 0.056 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0

Your query selected 961 sequences in 101 clusters.