ID Q04762 PRELIMINARY; PRT; 141 AA. AC Q04762; DT 01-NOV-1996 (TrEMBLrel. 01, Created) DT 01-NOV-1996 (TrEMBLrel. 01, Last sequence update) DT 01-MAY-1999 (TrEMBLrel. 10, Last annotation update) DE CELL ADHESION REGULATORY PROTEIN (CAR). GN CAR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=COLON CARCINOMA; RX MEDLINE=92220167; PubMed=1560826; RA Pullman W.E., Bodmer W.F.; RT "Cloning and characterization of a gene that regulates cell RT adhesion."; RL Nature 356:529-532(1992). RN [2] RP SEQUENCE OF 85-112 FROM N.A. RX MEDLINE=93252394; PubMed=8098008; RA Koyama K., Emi M., Nakamura Y.; RT "The cell adhesion regulator (CAR) gene, TaqI and insertion/deletion RT polymorphisms, and regional assignment to the peritelomeric region of RT 16q by linkage analysis."; RL Genomics 16:264-265(1993). CC -!- FUNCTION: THIS IS A CELL ADHESION PROTEIN WHICH MAY PLAY A ROLE IN CC SIGNAL TRANSDUCTION, COUPLING THE CYTOPLASMIC PORTION OF ADHESION CC MOLECULES TO THE CYTOSKELETON AND ENABLING THE EXTERNAL CC ENVIRONMENT TO INFLUENCE THE CELL SHAPE AND BEHAVIOUR. IT MAY CC FUNCTION IN THE SUPPRESSION OF TUMOUR INVASION. CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC. DR EMBL; X65784; CAA46667.1; -. DR EMBL; D14075; BAA03160.1; -. KW Cell adhesion; Phosphorylation; Myristylation; Polymorphism. FT INIT_MET 0 0 PROBABLE. FT LIPID 1 1 MYRISTATE. FT MOD_RES 141 141 PHOSPHORYLATION (BY TYR-KINASE) FT (POTENTIAL). FT VARIANT 89 109 PVRPRHWAPEDSPLPPAAMWT -> FT ASQAGTGLRRLTAPCC HVDWC (IN JV.1). FT VARIANT 89 112 PVRPRHWAPEDSPLPPAAMWTWCK -> ATQSGPGTGLRR FT LTTAPCCHVDWC (IN JV.2). FT MUTAGEN 141 141 Y->*: ABOLISHES ENHANCEMENT OF FT CELL-MATRIX ADHESION. SQ SEQUENCE 141 AA; 15604 MW; A6299E9D79B71936 CRC64; GKVISASRVS MEHFEFQGYR QSFPVWLRPP RGSRAFRLQT DPCSCRCLHD RPSSCGSLGM LRGSDMKGPC EPIVLSPAAL SSSSLINGPV RPRHWAPEDS PLPPAAMWTW CKLRTSCWSS HACSVGDALV FTALRIVEIL Y //