ID NEF_SIVSP STANDARD; PRT; 261 AA. AC P19501; DT 01-FEB-1991 (Rel. 17, Created) DT 01-FEB-1991 (Rel. 17, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF). GN NEF. OS Simian immunodeficiency virus (PBj14/BCL-3 isolate) (sooty mangabey). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11738; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=90272009; PubMed=1971917; RA Dewhurst S., Embretson J.E., Anderson D.C., Mullins J.I., Fultz P.N.; RT "Sequence analysis and acute pathogenicity of molecularly cloned RT SIVSMM-PBj14."; RL Nature 345:636-640(1990). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=92368737; PubMed=1503826; RA Dewhurst S., Embretson J.E., Fultz P.N., Mullins J.I.; RT "Molecular clones from a non-acutely pathogenic derivative of RT SIVsmmPBj14: characterization and comparison to acutely pathogenic RT clones."; RL AIDS Res. Hum. Retroviruses 8:1179-1187(1992). CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; L03298; AAA47782.1; -. DR EMBL; M31325; AAA47758.1; -. DR HSSP; P03406; 1EFN. DR HIV; M31325; NEF$SMMPBJ. DR INTERPRO; IPR001558; -. DR PFAM; PF00469; F-protein; 1. KW AIDS; Myristate; GTP-binding. FT LIPID 2 2 MYRISTATE (BY SIMILARITY). SQ SEQUENCE 261 AA; 30088 MW; AAD7A0BECD9C4847 CRC64; MGGVTSKKQR RRGGNLYERL LQARGETYGR LWEGLEGEYS QSQDASGKGL SSLSCEPQKY CEGQFMNTPW RNPATERAKL DYRQQNMDDV DSADLVGCPV SPRVPVRIMT YKLAIDMSHF IKEKGGLEGI YYSDRRHKIL DLYLEKEEGI IPDWQNYTAG PGIRYPMFFG WLWKLVPVNV SDEAQEDETH YLMHPAQTSQ WDDPWGEVLA WKFDPKLAYN YKAFVEHPEE FGSQSGLSKE EVQRRLTARG LLKMADKKKT S //