ID NEF_HV2ST STANDARD; PRT; 255 AA. AC P20868; DT 01-FEB-1991 (Rel. 17, Created) DT 01-FEB-1991 (Rel. 17, Last sequence update) DT 01-JUL-1993 (Rel. 26, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF). GN NEF. OS Human immunodeficiency virus type 2 (isolate ST) (HIV-2). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11721; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=90112662; PubMed=2296086; RA Kumar P., Hui H., Kappes J.C., Haggarty B.S., Hoxie J.A., Arya S.K., RA Shaw G.M., Hahn B.H.; RT "Molecular characterization of an attenuated human immunodeficiency RT virus type 2 isolate."; RL J. Virol. 64:890-901(1990). CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M31113; AAB01359.1; -. DR PIR; I33943; ASLJSZ. DR HSSP; P03406; 1EFN. DR HIV; M31113; NEF$2ST. DR INTERPRO; IPR001558; -. DR PFAM; PF00469; F-protein; 1. KW AIDS; Myristate; GTP-binding. FT LIPID 2 2 MYRISTATE (BY SIMILARITY). SQ SEQUENCE 255 AA; 29136 MW; 8CBC078DC862C3D0 CRC64; MGASGSKKRS EPSRGLRERL LQTPGEASGG HWDKLGGEYL QSQEGSGRGQ KSPSCEGRRY QQGDFMNTPW RAPAEGEKGS YKQQNMDDVD SDDDDLVGVP VTPRVPLREM TYRLARDMSH LIKEKGGLEG LYYSDRRRRV LDIYLEKEEG IIGDWQNYTH GPGVRYPKFF GWLWKLVPVD VPQEGDDSET HCLVHPAQTS RFDDPHGETL VWRFDPTLAF SYEAFIRYPE EFGYKSGLPE DEWKARLKAR GIPFS //