ID NEF_HV2G1 STANDARD; PRT; 255 AA. AC P18038; DT 01-NOV-1990 (Rel. 16, Created) DT 01-NOV-1990 (Rel. 16, Last sequence update) DT 01-JUL-1993 (Rel. 26, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF). GN NEF. OS Human immunodeficiency virus type 2 (isolate Ghana-1) (HIV-2). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11717; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=90122350; PubMed=2611042; RA Hasegawa A., Tsujimoto H., Maki N., Ishikawa K.I., Miura T., RA Fukasawa M., Miki K., Hayami M.; RT "Genomic divergence of HIV-2 from Ghana."; RL AIDS Res. Hum. Retroviruses 5:593-604(1989). CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M30895; AAA43937.1; -. DR PIR; JS0335; ASLJGN. DR HSSP; P03406; 1EFN. DR HIV; M30895; NEF$2GH1. DR INTERPRO; IPR001558; -. DR PFAM; PF00469; F-protein; 1. KW AIDS; Myristate; GTP-binding. FT LIPID 2 2 MYRISTATE (BY SIMILARITY). SQ SEQUENCE 255 AA; 29249 MW; 6CC3AA003D30A916 CRC64; MGASGSKKHS KHSQRLRERL LRAHGGGYVQ QCNASGGEYS QSQEGSGKGQ KSPSCEGQQY RQGDFMNTPW RTPAIEGQKK LYKQQNMDDI DSSDDDLVGV PVTPRVPLRA MTYKLAVDMS HFIKKRGLDG MFYSRDRHRI LDLYLEKEEG IIPDWQNYTH GPGVRYPMCF GWLWKLVPVD VSQEAEDDET NYLTHPAQTS RHDDEHGETL LWRFDPTLAY DYKAFILHPE EFGHKSGLPE KEWKAKLKAR GIPYS //