ID NEF_HV1S3 STANDARD; PRT; 205 AA. AC P19545; DT 01-FEB-1991 (Rel. 17, Created) DT 01-FEB-1991 (Rel. 17, Last sequence update) DT 01-JUL-1993 (Rel. 26, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF). GN NEF. OS Human immunodeficiency virus type 1 (SF33 isolate) (HIV-1). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11690; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=90317906; PubMed=2370688; RA York-Higgins D., Cheng-Mayer C., Bauer D., Levy J.A., Dina D.; RT "Human immunodeficiency virus type 1 cellular host range, replication, RT and cytopathicity are linked to the envelope region of the viral RT genome."; RL J. Virol. 64:4016-4020(1990). CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M38427; AAA45068.1; -. DR HSSP; P03406; 1EFN. DR HIV; M38427; NEF$SF33. DR INTERPRO; IPR001558; -. DR PFAM; PF00469; F-protein; 1. KW AIDS; Myristate; GTP-binding. FT LIPID 2 2 MYRISTATE (BY SIMILARITY). SQ SEQUENCE 205 AA; 23318 MW; FFB419A1C5DFC9F3 CRC64; MGGKWSKSKM GWPAVRERMK RAEPAADGVG AASRDLEKHG ALTSSNTAAT NADCAWLEAQ EDEEVGFPVK PQVPLRPMTY KAALDLSHFL KEKGGLEGLV YSQKRQDILD LWIYHTQGYF PDWQNYTPGP GVRFPLTFGW CFKLVPVEPE KVEEANEGEN NSLLHPMSLH GMEDPEKEVL VWKFDSHLAF RHMARELHPE YYKDC //