ID NEF_HV1LW STANDARD; PRT; 206 AA. AC Q70627; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF). GN NEF. OS Human immunodeficiency virus type 1 (LW12.3 isolate) (HIV-1). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=82834; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95127297; PubMed=7826699; RA Reitz M.S. Jr., Hall L., Robert-Guroff M., Lautenberger J., Hahn B.M., RA Shaw G.M., Kong L.I., Weiss S.H., Waters D., Gallo R.C., Blattner W.; RT "Viral variability and serum antibody response in a laboratory worker RT infected with HIV type 1 (HTLV type IIIB)."; RL AIDS Res. Hum. Retroviruses 10:1143-1155(1994). RN [2] RP STRUCTURE BY NMR OF 56-206. RX MEDLINE=97337445; PubMed=9194185; RA Grzesiek S., Bax A., Hu J.S., Kaufman J., Palmer I., Stahl S.J., RA Tjandra N., Wingfield P.T.; RT "Refined solution structure and backbone dynamics of HIV-1 Nef."; RL Protein Sci. 6:1248-1263(1997). CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U12055; AAA76691.1; -. DR PDB; 2NEF; 07-JUL-97. DR INTERPRO; IPR001558; -. DR PFAM; PF00469; F-protein; 1. KW AIDS; Myristate; GTP-binding; 3D-structure. FT LIPID 2 2 MYRISTATE. SQ SEQUENCE 206 AA; 23414 MW; ED81F68F6B61278E CRC64; MGGKWSKSSV IGWPTVRERM RRAEPAADGV GAASQDLEKH GAITSSNTAA TNADCAWLEA QEEEEVGFPV TPQVPLRPMT YKAAVDLSHF LKEKGGLEGL IHSQRRQDIL DLWIYHTQGY FPDWQNYTPG PGIRYPLTFG WCYKLVPVEP EKLEEANKGE NTSLLHPVSL HGMDDPEREV LEWRFDSRLA FHHVARELHP EYFKNC //