ID NEF_HV1BR STANDARD; PRT; 206 AA. AC P03406; DT 21-JUL-1986 (Rel. 01, Created) DT 21-JUL-1986 (Rel. 01, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN) (3'ORF). GN NEF. OS Human immunodeficiency virus type 1 (BRU isolate) (HIV-1), and OS Human immunodeficiency virus type 1 (New York-5 isolate) (HIV-1). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11686; 11698; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=ISOLATE BRU; RX MEDLINE=85099333; PubMed=2981635; RA Wain-Hobson S., Sonigo P., Danos O., Cole S., Alizon M.; RT "Nucleotide sequence of the AIDS virus, LAV."; RL Cell 40:9-17(1985). RN [2] RP SEQUENCE FROM N.A. (CLONE PNL4-3). RC STRAIN=ISOLATE NEW YORK-5; RA Buckler C.E., Buckler-White A.J., Willey R.L., McCoy J.; RL Submitted (JUN-1988) to the EMBL/GenBank/DDBJ databases. RN [3] RP POST-TRANSLATIONAL MODIFICATIONS, AND FUNCTION. RX MEDLINE=88039140; PubMed=3118220; RA Guy B., Kieny M.-P., Riviere Y., le Peuch C., Dott K., Girard M., RA Montagnier L., Lecocq J.-P.; RT "HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling RT an oncogene product."; RL Nature 330:266-269(1987). RN [4] RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 54-205 IN COMPLEX WITH NEF. RX MEDLINE=96279837; PubMed=8681387; RA Lee C.H., Saksela K., Mirza U.A., Chait B.T., Kuriyan J.; RT "Crystal structure of the conserved core of HIV-1 Nef complexed with a RT Src family SH3 domain."; RL Cell 85:931-942(1996). CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; K02013; AAB59752.1; -. DR EMBL; M19921; AAA44993.1; -. DR EMBL; A04321; CAA00353.1; -. DR PIR; A04008; ASLJFV. DR PDB; 1EFN; 11-JAN-97. DR HIV; K02013; NEF$BRU. DR HIV; M19921; NEF$NL43. DR INTERPRO; IPR001558; -. DR PFAM; PF00469; F-protein; 1. KW AIDS; Myristate; GTP-binding; Phosphorylation; 3D-structure. FT LIPID 2 2 MYRISTATE. FT MOD_RES 15 15 PHOSPHORYLATION (BY PKC). FT VARIANT 11 11 V -> I (IN CLONE PNL4-3). FT VARIANT 15 15 T -> A (IN CLONE PNL4-3). FT VARIANT 33 33 A -> V (IN CLONE PNL4-3). FT VARIANT 51 51 T -> N (IN CLONE PNL4-3). SQ SEQUENCE 206 AA; 23342 MW; 77453FC80B6004F2 CRC64; MGGKWSKSSV VGWPTVRERM RRAEPAADGV GAASRDLEKH GAITSSNTAA TNAACAWLEA QEEEEVGFPV TPQVPLRPMT YKAAVDLSHF LKEKGGLEGL IHSQRRQDIL DLWIYHTQGY FPDWQNYTPG PGVRYPLTFG WCYKLVPVEP DKVEEANKGE NTSLLHPVSL HGMDDPEREV LEWRFDSRLA FHHVARELHP EYFKNC //