ID HIA2_DICDI STANDARD; PRT; 117 AA. AC P42526; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE HISACTOPHILIN 2 (HISTIDINE-RICH ACTIN-BINDING PROTEIN 2) (HS II). GN HATB. OS Dictyostelium discoideum (Slime mold). OC Eukaryota; Dictyosteliida; Dictyostelium. OX NCBI_TaxID=44689; RN [1] RP SEQUENCE FROM N.A., PARTIAL SEQUENCE, AND POST-TRANSLATIONAL MOD. RC STRAIN=AX2, AND AX3; RX MEDLINE=95122497; PubMed=7822284; RA Hanakam F., Eckerskorn C., Lottspeich F., Mueller-Taubenberger A., RA Schaefer W., Gerisch G.; RT "The pH-sensitive actin-binding protein hisactophilin of Dictyostelium RT exists in two isoforms which both are myristoylated and distributed RT between plasma membrane and cytoplasm."; RL J. Biol. Chem. 270:596-602(1995). CC -!- FUNCTION: MAY ACT AS AN INTRACELLULAR PH SENSOR THAT LINKS CC CHEMOTACTIC SIGNALS TO RESPONSES IN THE MICROFILAMENT SYSTEM OF CC THE CELLS BY NUCLEATING ACTIN POLYMERIZATION OR STABILIZING THE CC FILAMENTS. CC -!- SUBUNIT: HOMODIMER OR HETERODIMER OF HSI AND HSII, LINKED BY A CC DISULFIDE BOND. CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC OR ASSOCIATED WITH INNER SURFACE CC OF PLASMA MEMBRANE. CC -!- PTM: PHOSPHORYLATED (IN VIVO). CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; U13671; AAA66208.1; -. DR HSSP; P13231; 1HCD. DR DICTYDB; DD01074; hatB. KW Actin-binding; Repeat; Myristate; Multigene family; KW Phosphorylation. FT INIT_MET 0 0 FT LIPID 1 1 MYRISTATE. FT DOMAIN 7 108 CONTAINS SEVERAL HHXH REPEATS. FT DOMAIN 33 85 2 X 13 AA APPROXIMATE REPEATS. FT REPEAT 33 45 1. FT REPEAT 73 85 2. SQ SEQUENCE 117 AA; 13503 MW; C92D50147FB8E0F8 CRC64; GNRAFKAHNG HYLSAEHDHV KTHHGHHDHH THFHIENHGS KVALRTHCGK YVSIGDHKQV YLSHHLHGDH SLFHLEHHHG KVSIKGHHHH YISVDGHGHV STSHHHDHHA TFEEHIL //