ID GAG_HV1U4 STANDARD; PRT; 492 AA. AC P24736; DT 01-MAR-1992 (Rel. 21, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE GAG POLYPROTEIN [CONTAINS: CORE PROTEINS P17, P24, P2, P7, P1, P6]. GN GAG. OS Human immunodeficiency virus type 1 (strain Ugandan / isolate U455) OS (HIV-1). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11703; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=91090981; PubMed=2265025; RA Oram J.D., Downing R.G., Roff M., Clegg J.C.S., Serwadda D., RA Carswell J.W.; RT "Nucleotide sequence of a Ugandan HIV-1 provirus reveals genetic RT diversity from other HIV-1 isolates."; RL AIDS Res. Hum. Retroviruses 6:1073-1078(1990). CC -!- FUNCTION: PERFORMS HIGHLY COMPLEX ORCHESTRATED TASKS DURING THE CC ASSEMBLY, BUDDING, MATURATION, AND INFECTION STAGES OF THE VIRAL CC REPLICATION CYCLE. DURING VIRAL ASSEMBLY, THE PROTEINS FORM CC MEMBRANE ASSOCIATIONS AND SELF-ASSOCIATIONS THAT ULTIMATELY CC RESULT IN BUDDING OF AN IMMATURE VIRION FROM THE INFECTED CELL. CC GAG PRECURSORS ALSO FUNCTION DURING VIRAL ASSEMBLY TO SELECTIVELY CC BIND AND PACKAGE TWO PLUS STRANDS OF GENOMIC RNA. CC -!- PTM: THE P24 PROTEIN IS PHOSPHORYLATED. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M62320; AAA75018.1; -. DR HSSP; P05888; 1AAF. DR INTERPRO; IPR000071; -. DR INTERPRO; IPR000721; -. DR INTERPRO; IPR001878; -. DR PFAM; PF00540; gag_p17; 1. DR PFAM; PF00607; gag_p24; 1. DR PFAM; PF00098; zf-CCHC; 2. DR PRINTS; PR00234; HIV1MATRIX. DR PRINTS; PR00939; C2HCZNFINGER. KW AIDS; Core protein; Polyprotein; Myristate; Phosphorylation; KW Zinc-finger. FT INIT_MET 0 0 BY SIMILARITY. FT CHAIN 1 127 CORE PROTEIN P17 (MATRIX PROTEIN). FT CHAIN 128 358 CORE PROTEIN P24 (CORE ANTIGEN). FT CHAIN 359 371 CORE PROTEIN P2. FT CHAIN 372 425 CORE PROTEIN P7 (NUCLEOCAPSID PROTEIN). FT CHAIN 426 441 CORE PROTEIN P1. FT CHAIN 442 492 CORE PROTEIN P6. FT LIPID 1 1 MYRISTATE (BY SIMILARITY). FT ZN_FING 385 398 C2HC-TYPE. SQ SEQUENCE 492 AA; 54791 MW; E4A3B4D633BB6972 CRC64; GARASVLSGK KLDSWEKIRL RPGGNKKYRL KHLVWASREL EKFTLNPGLL ETAEGCQQIL GQLQPALQTG TEELRSLYNT VAVLYCVHQR IDVKDTKEAL NKIEEMQNKN KQRTQQAAAN TGSSQNYPIV QNAQGQPVHQ ALSPRTLNAW VKVVEDKAFS PEVIPMFSAL SEGATPQDLN MMLNVVGGHQ AAMQMLKDTI NEEAAEWDRL HPVHAGPIPP GQMREPRGSD IAGTTSTVQE QIGWMTGNPP IPVGDIYRRW IILGLNKIVR MYSPVSILDI RQGPKEPFRD YVDRFFKTLR AEQATQDVKN WMTETLLVQN ANPDCKSILR ALGPGATLEE MMTACQGVGG PGHKARVLAE AMSQVQQTSI MMQRGNFRGP RRIKCFNCGK EGHLAKNCRA PRKKGCWKCG KEGHQMKDCT ERQANFLGKI WPSNKGRPGN FPQSRPEPTA PPAEIFGMGE KMTSPAKQEL KDREQTPLVS LKSLFGNDPL SQ //