ID GAG_HV1A2 STANDARD; PRT; 501 AA. AC P03349; DT 21-JUL-1986 (Rel. 01, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE GAG POLYPROTEIN [CONTAINS: CORE PROTEINS P17, P24, P2, P7, P1, P6]. GN GAG. OS Human immunodeficiency virus type 1 (ARV2/SF2 isolate) (HIV-1). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11685; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85090453; PubMed=2578227; RA Sanchez-Pescador R., Power M.D., Barr P.J., Steimer K.S., RA Stempien M.M., Brown-Shimer S.L., Gee W.W., Renard A., Randolph A., RA Levy J.A., Dina D., Luciw P.A.; RT "Nucleotide sequence and expression of an AIDS-associated retrovirus RT (ARV-2)."; RL Science 227:484-492(1985). CC -!- FUNCTION: PERFORMS HIGHLY COMPLEX ORCHESTRATED TASKS DURING THE CC ASSEMBLY, BUDDING, MATURATION, AND INFECTION STAGES OF THE VIRAL CC REPLICATION CYCLE. DURING VIRAL ASSEMBLY, THE PROTEINS FORM CC MEMBRANE ASSOCIATIONS AND SELF-ASSOCIATIONS THAT ULTIMATELY CC RESULT IN BUDDING OF AN IMMATURE VIRION FROM THE INFECTED CELL. CC GAG PRECURSORS ALSO FUNCTION DURING VIRAL ASSEMBLY TO SELECTIVELY CC BIND AND PACKAGE TWO PLUS STRANDS OF GENOMIC RNA. CC -!- PTM: THE P24 PROTEIN IS PHOSPHORYLATED. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; K02007; AAB59875.1; -. DR PIR; A03947; FOVWA2. DR HSSP; P05888; 1AAF. DR HIV; K02007; GAG$SF2. DR INTERPRO; IPR000071; -. DR INTERPRO; IPR000721; -. DR INTERPRO; IPR001878; -. DR PFAM; PF00540; gag_p17; 1. DR PFAM; PF00607; gag_p24; 1. DR PFAM; PF00098; zf-CCHC; 2. DR PRINTS; PR00234; HIV1MATRIX. DR PRINTS; PR00939; C2HCZNFINGER. KW AIDS; Core protein; Polyprotein; Myristate; Phosphorylation; KW Zinc-finger. FT INIT_MET 0 0 BY SIMILARITY. FT CHAIN 1 133 CORE PROTEIN P17 (MATRIX PROTEIN). FT CHAIN 134 364 CORE PROTEIN P24 (CORE ANTIGEN). FT CHAIN 365 378 CORE PROTEIN P2. FT CHAIN 379 433 CORE PROTEIN P7 (NUCLEOCAPSID PROTEIN). FT CHAIN 434 449 CORE PROTEIN P1. FT CHAIN 450 501 CORE PROTEIN P6. FT LIPID 1 1 MYRISTATE (BY SIMILARITY). FT ZN_FING 393 406 C2HC-TYPE. SQ SEQUENCE 501 AA; 55935 MW; 8F36C928D5EDBA45 CRC64; GARASVLSGG ELDKWEKIRL RPGGKKKYKL KHIVWASREL ERFAVNPGLL ETSEGCRQIL GQLQPSLQTG SEELRSLYNT VATLYCVHQR IDVKDTKEAL EKIEEEQNKS KKKAQQAAAA AGTGNSSQVS QNYPIVQNLQ GQMVHQAISP RTLNAWVKVV EEKAFSPEVI PMFSALSEGA TPQDLNTMLN TVGGHQAAMQ MLKETINEEA AEWDRVHPVH AGPIAPGQMR EPRGSDIAGT TSTLQEQIGW MTNNPPIPVG EIYKRWIILG LNKIVRMYSP TSILDIRQGP KEPFRDYVDR FYKTLRAEQA SQDVKNWMTE TLLVQNANPD CKTILKALGP AATLEEMMTA CQGVGGPGHK ARVLAEAMSQ VTNPANIMMQ RGNFRNQRKT VKCFNCGKEG HIAKNCRAPR KKGCWRCGRE GHQMKDCTER QANFLGKIWP SYKGRPGNFL QSRPEPTAPP EESFRFGEEK TTPSQKQEPI DKELYPLTSL RSLFGNDPSS Q //