ID   ARF4_HUMAN     STANDARD;      PRT;   179 AA.
AC   P18085; P21371;
DT   01-MAY-1991 (Rel. 18, Created)
DT   01-JUN-1994 (Rel. 29, Last sequence update)
DT   01-OCT-1996 (Rel. 34, Last annotation update)
DE   ADP-RIBOSYLATION FACTOR 4.
GN   ARF4.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=90192776; PubMed=2107548;
RA   Monaco L., Murtagh J.J. Jr., Newman K.B., Tsai S.-C., Moss J.,
RA   Vaughan M.;
RT   "Selective amplification of an mRNA and related pseudogene for a human
RT   ADP-ribosylation factor, a guanine nucleotide-dependent protein
RT   activator of cholera toxin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:2206-2210(1990).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=91115891; PubMed=1899243;
RA   Kahn R.A., Kern F.G., Clark J., Gelmann E.P., Rulka C.;
RT   "Human ADP-ribosylation factors. A functionally conserved family of
RT   GTP-binding proteins.";
RL   J. Biol. Chem. 266:2606-2614(1991).
CC   -!- FUNCTION: GTP-BINDING PROTEIN THAT FUNCTIONS AS AN ALLOSTERIC
CC       ACTIVATOR OF THE CHOLERA TOXIN CATALYTIC SUBUNIT, AN ADP-
CC       RIBOSYLTRANSFERASE. INVOLVED IN PROTEIN TRAFFICKING; MAY MODULATE
CC       VESICLE BUDDING AND UNCOATING WITHIN THE GOLGI APPARATUS.
CC   -!- SIMILARITY: BELONGS TO THE ARF FAMILY OF GTP-BINDING PROTEINS.
CC   -!- CAUTION: WAS ORIGINALLY THOUGHT TO BE ARF2.
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DR   EMBL; M36341; AAA53081.1; -.
DR   PIR; A35091; A35091.
DR   PIR; B38622; B38622.
DR   HSSP; P32889; 1HUR.
DR   MIM; 601177; -.
DR   INTERPRO; IPR000251; -.
DR   PFAM; PF00025; arf; 1.
DR   PROSITE; PS01019; ARF; 1.
KW   GTP-binding; Multigene family; Myristate; Protein transport;
KW   Golgi stack.
FT   INIT_MET      0      0       BY SIMILARITY.
FT   LIPID         1      1       MYRISTATE (POTENTIAL).
FT   NP_BIND      23     30       GTP (BY SIMILARITY).
FT   NP_BIND      66     70       GTP (BY SIMILARITY).
FT   NP_BIND     125    128       GTP (BY SIMILARITY).
SQ   SEQUENCE   179 AA;  20379 MW;  D743A62B6A2AA912 CRC64;
     GLTISSLFSR LFGKKQMRIL MVGLDAAGKT TILYKLKLGE IVTTIPTIGF NVETVEYKNI
     CFTVWDVGGQ DRIRPLWKHY FQNTQGLIFV VDSNDRERIQ EVADELQKML LVDELRDAVL
     LLFANKQDLP NAMAISEMTD KLGLQSLRNR TWYVQATCAT QGTGLYEGLD WLSNELSKR
//