ID ARF3_HUMAN STANDARD; PRT; 180 AA. AC P16587; DT 01-AUG-1990 (Rel. 15, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE ADP-RIBOSYLATION FACTOR 3. GN ARF3. OS Homo sapiens (Human), Mus musculus (Mouse), Rattus norvegicus (Rat), OS and Fugu rubripes (Japanese pufferfish) (Takifugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; 10090; 10116; 31033; RN [1] RP SEQUENCE FROM N.A. RC SPECIES=Human; RX MEDLINE=89345613; PubMed=2474826; RA Bobak D.A., Nightingale M.S., Murtagh J.J. Jr., Price S.R., Moss J., RA Vaughan M.; RT "Molecular cloning, characterization, and expression of human ADP- RT ribosylation factors: two guanine nucleotide-dependent activators of RT cholera toxin."; RL Proc. Natl. Acad. Sci. U.S.A. 86:6101-6105(1989). RN [2] RP SEQUENCE FROM N.A. RC SPECIES=Human; RX MEDLINE=92078170; PubMed=1744102; RA Tsai S.C., Haun R.S., Tsuchiya M., Moss J., Vaughan M.; RT "Isolation and characterization of the human gene for ADP-ribosylation RT factor 3, a 20-kDa guanine nucleotide-binding protein activator of RT cholera toxin."; RL J. Biol. Chem. 266:23053-23059(1991). RN [3] RP SEQUENCE FROM N.A. RC SPECIES=Rat; TISSUE=BRAIN; RA Nightingale M.S., Price S.R., Tsuchiya M., Moss J., Vaughan M.; RL Submitted (XXX-1994) to the EMBL/GenBank/DDBJ databases. RN [4] RP SEQUENCE FROM N.A. RC SPECIES=Mouse; STRAIN=ICR; TISSUE=BRAIN; RX MEDLINE=97103475; PubMed=8947846; RA Hosaka M., Toda K., Takatsu H., Torii S., Murakami K., Nakayama K.; RT "Structure and intracellular localization of mouse ADP-ribosylation RT factors type 1 to type 6 (ARF1-ARF6)."; RL J. Biochem. 120:813-819(1996). RN [5] RP SEQUENCE FROM N.A. RC SPECIES=F.rubripes; RX MEDLINE=99177347; PubMed=10077531; RA Gellner K., Brenner S.; RT "Analysis of 148 kb of genomic DNA around the wnt1 locus of Fugu RT rubripes."; RL Genome Res. 9:251-258(1999). CC -!- FUNCTION: GTP-BINDING PROTEIN THAT FUNCTIONS AS AN ALLOSTERIC CC ACTIVATOR OF THE CHOLERA TOXIN CATALYTIC SUBUNIT, AN ADP- CC RIBOSYLTRANSFERASE. INVOLVED IN PROTEIN TRAFFICKING; MAY MODULATE CC VESICLE BUDDING AND UNCOATING WITHIN THE GOLGI APPARATUS. CC -!- SIMILARITY: BELONGS TO THE ARF FAMILY OF GTP-BINDING PROTEINS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- DR EMBL; M74493; AAA58359.1; -. DR EMBL; M33384; AAA83931.1; -. DR EMBL; M74491; AAB59425.1; -. DR EMBL; L12382; AAA40687.1; -. DR EMBL; D87900; BAA13492.1; -. DR EMBL; AF056116; AAC34390.1; -. DR PIR; B33283; B33283. DR PIR; A41570; A41570. DR PIR; B41570; B41570. DR HSSP; P32889; 1RRF. DR MIM; 103190; -. DR MGD; MGI:99432; Arf3. DR INTERPRO; IPR000251; -. DR PFAM; PF00025; arf; 1. DR PROSITE; PS01019; ARF; 1. KW GTP-binding; Multigene family; Myristate; Protein transport; KW Golgi stack. FT INIT_MET 0 0 BY SIMILARITY. FT LIPID 1 1 MYRISTATE (POTENTIAL). FT NP_BIND 23 30 GTP (BY SIMILARITY). FT NP_BIND 66 70 GTP (BY SIMILARITY). FT NP_BIND 125 128 GTP (BY SIMILARITY). SQ SEQUENCE 180 AA; 20469 MW; 6D472300CEB0BCED CRC64; GNIFGNLLKS LIGKKEMRIL MVGLDAAGKT TILYKLKLGE IVTTIPTIGF NVETVEYKNI SFTVWDVGGQ DKIRPLWRHY FQNTQGLIFV VDSNDRERVN EAREELMRML AEDELRDAVL LVFANKQDLP NAMNAAEITD KLGLHSLRHR NWYIQATCAT SGDGLYEGLD WLANQLKNKK //