ID   25A2_HUMAN     STANDARD;      PRT;   726 AA.
AC   P29728;
DT   01-APR-1993 (Rel. 25, Created)
DT   01-APR-1993 (Rel. 25, Last sequence update)
DT   01-OCT-2000 (Rel. 40, Last annotation update)
DE   (2'-5')OLIGOADENYLATE SYNTHETASE 2 (EC 2.7.7.-) ((2-5')OLIGO(A)
DE   SYNTHETASE 2) (2-5A SYNTHETASE 2) (P69/P71) (P69OAS/P71OAS).
GN   OAS2.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=92250658; PubMed=1577824;
RA   Marie I., Hovanessian A.G.;
RT   "The 69-kDa 2-5A synthetase is composed of two homologous and adjacent
RT   functional domains.";
RL   J. Biol. Chem. 267:9933-9939(1992).
CC   -!- CATALYTIC ACTIVITY: BINDS DOUBLE-STRANDED RNA AND POLYMERIZES ATP
CC       INTO PPP(A2'P5'A)N OLIGOMERS, WHICH ACTIVATE THE LATENT RNASE L
CC       THAT, WHEN ACTIVATED, CLEAVES SINGLE-STRANDED RNAS.
CC   -!- SUBUNIT: HOMODIMER.
CC   -!- SUBCELLULAR LOCATION: ASSOCIATED WITH DIFFERENT SUBCELLULAR
CC       FRACTIONS SUCH AS MITOCHONDRIAL, NUCLEAR, AND ROUGH/SMOOTH
CC       MICROSOMAL FRACTIONS.
CC   -!- ALTERNATIVE PRODUCTS: 2 ISOFORMS; 71 KDA/P71 (SHOWN HERE) AND 69
CC       KDA/P69; ARE PRODUCED BY ALTERNATIVE SPLICING.
CC   -!- INDUCTION: BY INTERFERONS.
CC   -!- SIMILARITY: BELONGS TO THE 2-5A SYNTHETASE FAMILY.
CC   --------------------------------------------------------------------------
CC   This SWISS-PROT entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use  by  non-profit  institutions as long  as its content  is  in  no  way
CC   modified and this statement is not removed.  Usage  by  and for commercial
CC   entities requires a license agreement (See http://www.isb-sib.ch/announce/
CC   or send an email to license@isb-sib.ch).
CC   --------------------------------------------------------------------------
DR   EMBL; M87434; AAA60607.1; -.
DR   EMBL; M87284; AAA60606.1; -.
DR   MIM; 603350; -.
DR   INTERPRO; IPR001797; -.
DR   INTERPRO; IPR002934; -.
DR   PFAM; PF01909; NTP_transf_2; 1.
DR   PROSITE; PS00832; 25A_SYNTH_1; 2.
DR   PROSITE; PS00833; 25A_SYNTH_2; 2.
KW   RNA-binding; Transferase; Nucleotidyltransferase; Duplication;
KW   Interferon induction; Alternative splicing; Myristate.
FT   INIT_MET      0      0       PROBABLE.
FT   LIPID         1      1       MYRISTATE (PROBABLE).
FT   DOMAIN       10    334       OAS DOMAIN 1.
FT   DOMAIN      325    345       PRO-RICH (LINKER).
FT   DOMAIN      342    682       OAS DOMAIN 2.
FT   VARSPLIC    683    686       TMQT -> VKVI (IN ISOFORM P69).
FT   VARSPLIC    687    726       MISSING (IN ISOFORM P69).
SQ   SEQUENCE   726 AA;  83157 MW;  B69393195C6CA190 CRC64;
     GNGESQLSSV PAQKLGWFIQ EYLKPYEECQ TLIDEMVNTI CDVCRNPEQF PLVQGVAIGG
     SYGRKTVLRG NSDGTLVLFF SDLKQFQDQK RSQRDILDKT GDKLKFCLFT KWLKNNFEIQ
     KSLDGSTIQV FTKNQRISFE VLAAFNALSL NDNPSPWIYR ELKRSLDKTN ASPGEFAVCF
     TELQQKFFDN RPGKLKDLIL LIKHWHQQCQ KKIKDLPSLS PYALELLTVY AWEQGCRKDN
     FDIAEGVRTV LELIKCQEKL CIYWMVNYNF EDETIRNILL HQLQSARPVI LDPVDPTNNV
     SGDKICWQWL KKEAQTWLTS PNLDNELPAP SWNVLPAPLF TTPGHLLDKF IKEFLQPNKC
     FLEQIDSAVN IIRTFLKENC FRQSTAKIQI VRGGSTAKGT ALKTGSDADL VVFHNSLKSY
     TSQKNERHKI VKEIHEQLKA FWREKEEELE VSFEPPKWKA PRVLSFSLKS KVLNESVSFD
     VLPAFNALGQ LSSGSTPSPE VYAGLIDLYK SSDLPGGEFS TCFTVLQRNF IRSRPTKLKD
     LIRLVKHWYK ECERKLKPKG SLPPKYALEL LTIYAWEQGS GVPDFDTAEG FRTVLELVTQ
     YQQLGIFWKV NYNFEDETVR KFLLSQLQKT RPVILDPGEP TGDVGGGDRW CWHLLDKEAK
     VRLSSPCFKD GTGNPIPPWK VPTMQTPGSC GARIHPIVNE MFSSRSHRIL NNNSKRNFWR
     SSGNRF
//