ID VSM5_TRYBR STANDARD; PRT; 517 AA. AC P21840; DT 01-MAY-1991 (REL. 18, CREATED) DT 01-MAY-1991 (REL. 18, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE VARIANT SURFACE GLYCOPROTEIN MVAT5 PRECURSOR (VSG). OS TRYPANOSOMA BRUCEI RHODESIENSE. OC EUKARYOTA; PROTOZOA; SARCOMASTIGOPHORA; MASTIGOPHORA; KINETOPLASTIDA; OC TRYPANOSOMATIDAE. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=WRATAT 1; RX MEDLINE; 90290520. RA REDDY L.V., HALL T., DONELSON J.E.; RL BIOCHEM. BIOPHYS. RES. COMMUN. 169:730-736(1990). CC -!- FUNCTION: VSG FORMS A COAT ON THE SURFACE OF THE PARASITE. THE CC TYPANOSOME EVADES THE IMMUNE RESPONSE OF THE HOST BY EXPRESSING CC A SERIES OF ANTIGENICALLY DISTINCT VSGS FROM AN ESTIMATED 1000 CC VSG GENES. CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC A SOLUBLE FORM IS RELASED FROM RUPTURED CELLS BY THE ACTION OF A CC PI-PLC. DR EMBL; M33825; G162160; -. DR PIR; C35480; C35480. KW GLYCOPROTEIN; ANTIGEN; TRYPANOSOMIASIS; GPI-ANCHOR; MEMBRANE; SIGNAL. FT SIGNAL 1 ? POTENTIAL. FT CHAIN ? 495 VARIANT SURFACE GLYCOPROTEIN MVAT5. FT PROPEP 496 517 HYDROPHOBIC, REMOVED DURING MATURATION. FT LIPID 495 495 GPI-ANCHOR (BY SIMILARITY). FT CARBOHYD 435 435 POTENTIAL. SQ SEQUENCE 517 AA; 54191 MW; 62CCF80A CRC32; MIGKAFIILS LLNELPTPTA AQAAQGGALG KDVWLPLAKF TATAAKIPGR AAKLLQDRSA QIVNLMKLQV QADICLNKAA SEVSALGWQA LAVAIAADIG SLQSLQQQRS EEAIAAAAAA EFARGHAAEF FKVAAAVQSA ANSGCLTTNN KGGAAGSVIN GFSTLGTAEQ PAIGATSTAH VGDDITAITT TGFSDLAATD GIRTDSLTAD TNCVLFKGGS DGPLTTANFG QSIPFAGGYL TRNPTANTAS SADGTDFVSN PEDSKIAGIK VYRDAHAAAA KIRTAATFGS TFTDFKKLDQ AKKSVHLRAA VKNIILGKPD GSVDDLSGEI DTKINQVFGE DQETFHSRFW DQLTKVKVEK AASGQEETTL DAITSFAALS RARTYYSTKV IKGLRDKISS LEIKNSKTEV KVTDADCNKH QSKDKCAAPC KWNENTTDIN KKCSLDPVKA TEQQAAQTAG AGEGAAGTTT DKCKDKKKDD CKSPDCKWEG ETCKDSSILL NKQFALMVSA AFVALLF //