ID VSM4_TRYBB STANDARD; PRT; 526 AA. AC P02896; DT 21-JUL-1986 (REL. 01, CREATED) DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE) DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE) DE VARIANT SURFACE GLYCOPROTEIN MITAT 1.4A PRECURSOR (VSG 117). OS TRYPANOSOMA BRUCEI BRUCEI. OC EUKARYOTA; PROTOZOA; SARCOMASTIGOPHORA; MASTIGOPHORA; KINETOPLASTIDA; OC TRYPANOSOMATIDAE. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 83010278. RA BOOTHROYD J.C., PAYNTER C.A., COLEMAN S.L., CROSS G.A.M.; RL J. MOL. BIOL. 157:547-556(1982). RN [2] RP SEQUENCE OF 34-503. RX MEDLINE; 83010277. RA ALLEN G., GURNETT L.P., CROSS G.A.M.; RL J. MOL. BIOL. 157:527-546(1982). CC -!- FUNCTION: VSG FORMS A COAT ON THE SURFACE OF THE PARASITE. THE CC TYPANOSOME EVADES THE IMMUNE RESPONSE OF THE HOST BY EXPRESSING CC A SERIES OF ANTIGENICALLY DISTINCT VSGS FROM AN ESTIMATED 1000 CC VSG GENES. CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC A SOLUBLE FORM IS RELASED FROM RUPTURED CELLS BY THE ACTION OF A CC PI-PLC. DR EMBL; V01387; G10417; -. DR EMBL; J01214; G162392; -. DR EMBL; J01215; G162393; -. DR EMBL; J01215; E12134; -. DR PIR; A03391; VMUT8B. KW GLYCOPROTEIN; ANTIGEN; TRYPANOSOMIASIS; SIGNAL; GPI-ANCHOR; MEMBRANE. FT SIGNAL 1 33 FT CHAIN 34 503 VARIANT SURFACE GLYCOPROTEIN MITAT 1.4A. FT PROPEP 504 526 HYDROPHOBIC, REMOVED DURING MATURATION. FT DISULFID 47 173 BY SIMILARITY. FT DISULFID 154 215 BY SIMILARITY. FT CARBOHYD 453 453 FT LIPID 503 503 GPI-ANCHOR. SQ SEQUENCE 526 AA; 56318 MW; 385CD377 CRC32; MDCHTKETLG VTQWRRSTML TLSLLYAITP ADGAKEALEY KTWTNHCGLA ATLRKVAGGV LTKLKSHISY RKKLEEMETK LRIYALKGDG VGEQKSAEIL ATTAALMRQK ALTPEEANLK TALKAAGFAG EGAAAVSSYL MTLGTLTTSG SAHCLSNEGG DGDGKDQLAP KGCRHGTEAD FDAGAGPAES EVADSGFAQV PGKQDGANAG QANMCALFTH QATPHSSQGI YITGAQTKPS FGYGMLTIGT TDQTIGLKLS DIKGKQADSA QKFWSSCHAA VKAAQDMKAD PALKVDQTLL AVLVASPEMA EILKLEAAAS QQKGPEEVTI DLATEKNNYF GTNNNKLEPL WTKIKGQNIV DLAATKGSTK ELGTVTDTAE LQKLLSYYYT VNKEEQKKTA EKITKLETEL ADQKGKSPES ECNKISEEPK CNEDKICSWH KEVKAGEKHC KFNSTKAKEK GVSVTQTQTA GGTEATTDKC KGKLEDTCKK ESNCKWENNA CKDSSILVTK KFALTVVSAA FVALLF //