ID VSM2_TRYBB STANDARD; PRT; 476 AA. AC P26332; DT 01-MAY-1992 (REL. 22, CREATED) DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE) DT 01-FEB-1995 (REL. 31, LAST ANNOTATION UPDATE) DE VARIANT SURFACE GLYCOPROTEIN MITAT 1.2 PRECURSOR (VSG 221). OS TRYPANOSOMA BRUCEI BRUCEI. OC EUKARYOTA; PROTOZOA; SARCOMASTIGOPHORA; MASTIGOPHORA; KINETOPLASTIDA; OC TRYPANOSOMATIDAE. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=ISOLATE MIAG 221; RX MEDLINE; 92046037. RA CARRINGTON M., MILLER N., BLUM M., RODITI I., WILEY D., TURNER M.; RL J. MOL. BIOL. 221:823-835(1991). RN [2] RP SEQUENCE OF 1-59 AND 452-476 FROM N.A. RX MEDLINE; 82059496. RA BOOTHROYD J.C., PAYNTER C.A., CROSS G.A.M., BERNARDS A., BORST P.; RL NUCLEIC ACIDS RES. 9:4735-4743(1981). RN [3] RP SEQUENCE OF 1-28 FROM N.A. RX MEDLINE; 84106812. RA BERNARDS A., DE LANGE T., MICHELS P.A.M., LIU A.Y.C., HUISMAN M.J., RA BORST P.; RL CELL 36:163-170(1984). RN [4] RP X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 27-390. RX MEDLINE; 91039329. RA FREYMANN D., DOWN J., CARRINGTON M., RODITI I., TURNER M., WILEY D.C.; RL J. MOL. BIOL. 216:141-160(1990). CC -!- FUNCTION: VSG FORMS A COAT ON THE SURFACE OF THE PARASITE. THE CC TYPANOSOME EVADES THE IMMUNE RESPONSE OF THE HOST BY EXPRESSING CC A SERIES OF ANTIGENICALLY DISTINCT VSGS FROM AN ESTIMATED 1000 CC VSG GENES. CC -!- SUBUNIT: HOMODIMER. CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC A SOLUBLE FORM IS RELASED FROM RUPTURED CELLS BY THE ACTION OF A CC PI-PLC. DR EMBL; X56762; G10471; -. DR EMBL; K00640; G162350; -. DR EMBL; K00640; E13132; ALT_SEQ. DR EMBL; K00640; E13133; ALT_SEQ. DR EMBL; K00641; E12132; ALT_SEQ. DR EMBL; K01290; G552300; -. DR EMBL; K00641; G162351; -. DR PIR; S18451; S18451. DR PDB; 1VSG; 15-JAN-92. KW GLYCOPROTEIN; ANTIGEN; TRYPANOSOMIASIS; GPI-ANCHOR; MEMBRANE; SIGNAL; KW 3D-STRUCTURE. FT SIGNAL 1 26 FT CHAIN 27 459 VARIANT SURFACE GLYCOPROTEIN MITAT 1.2. FT PROPEP 460 476 HYDROPHOBIC, REMOVED DURING MATURATION. FT DISULFID 41 171 FT DISULFID 149 213 FT CARBOHYD 289 289 FT CARBOHYD 454 454 POTENTIAL. FT LIPID 459 459 GPI-ANCHOR. FT STRAND 30 32 FT HELIX 34 46 FT TURN 47 48 FT HELIX 49 81 FT TURN 82 84 FT HELIX 86 111 FT TURN 112 112 FT HELIX 113 140 FT STRAND 142 144 FT TURN 145 146 FT STRAND 147 148 FT STRAND 150 151 FT TURN 153 154 FT STRAND 158 158 FT STRAND 161 162 FT TURN 163 164 FT STRAND 165 166 FT TURN 167 168 FT STRAND 169 170 FT STRAND 189 189 FT TURN 190 191 FT STRAND 192 192 FT TURN 194 195 FT HELIX 202 205 FT TURN 206 206 FT STRAND 207 212 FT HELIX 214 216 FT TURN 220 222 FT STRAND 234 236 FT TURN 237 240 FT STRAND 241 243 FT STRAND 251 252 FT TURN 265 266 FT HELIX 267 277 FT TURN 278 278 FT TURN 282 283 FT HELIX 285 287 FT HELIX 294 296 FT HELIX 300 306 FT TURN 307 308 FT HELIX 316 327 FT HELIX 332 344 FT STRAND 346 346 FT HELIX 349 351 FT TURN 354 355 FT STRAND 359 359 FT HELIX 360 362 FT HELIX 366 387 SQ SEQUENCE 476 AA; 51041 MW; 1F03E89F CRC32; MPSNQEARLF LAVLVLAQVL PILVDSAAEK GFKQAFWQPL CQVSEELDDQ PKGALFTLQA AASKIQKMRD AALRASIYAE INHGTNRAKA AVIVANHYAM KADSGLEALK QTLSSQEVTA TATASYLKGR IDEYLNLLLQ TKESGTSGCM MDTSGTNTVT KAGGTIGGVP CKLQLSPIQP KRPAATYLGK AGYVGLTRQA DAANNFHDND AECRLASGHN TNGLGKSGQL SAAVTMAAGY VTVANSQTAV TVQALDALQE ASGAAHQPWI DAWKAKKALT GAETAEFRNE TAGIAGKTGV TKLVEEALLK KKDSEASEIQ TELKKYFSGH ENEQWTAIEK LISEQPVAQN LVGDNQPTKL GELEGNAKLT TILAYYRMET AGKFEVLTQK HKPAESQQQA AETEGSCNKK DQNECKSPCK WHNDAENKKC TLDKEEAKKV ADETAKDGKT GNTNTTGSSN SFVISKTPLW LAVLLF //