ID VSM1_TRYBB STANDARD; PRT; 492 AA. AC P26331; DT 01-MAY-1992 (REL. 22, CREATED) DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE) DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE) DE VARIANT SURFACE GLYCOPROTEIN MITAT 1.1 PRECURSOR (VSG). OS TRYPANOSOMA BRUCEI BRUCEI. OC EUKARYOTA; PROTOZOA; SARCOMASTIGOPHORA; MASTIGOPHORA; KINETOPLASTIDA; OC TRYPANOSOMATIDAE. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=ISOLATE MIAG 060; RX MEDLINE; 92046037. RA CARRINGTON M., MILLER N., BLUM M., RODITI I., WILEY D., TURNER M.; RL J. MOL. BIOL. 221:823-835(1991). CC -!- FUNCTION: VSG FORMS A COAT ON THE SURFACE OF THE PARASITE. THE CC TYPANOSOME EVADES THE IMMUNE RESPONSE OF THE HOST BY EXPRESSING CC A SERIES OF ANTIGENICALLY DISTINCT VSGS FROM AN ESTIMATED 1000 CC VSG GENES. CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC A SOLUBLE FORM IS RELASED FROM RUPTURED CELLS BY THE ACTION OF A CC PI-PLC. DR EMBL; X56761; G10469; -. DR PIR; S18445; S18445. KW GLYCOPROTEIN; ANTIGEN; TRYPANOSOMIASIS; GPI-ANCHOR; MEMBRANE; SIGNAL. FT SIGNAL 1 32 FT CHAIN 33 475 VARIANT SURFACE GLYCOPROTEIN MITAT 1.1. FT PROPEP 476 492 HYDROPHOBIC, REMOVED DURING MATURATION. FT DISULFID 47 177 BY SIMILARITY. FT DISULFID 155 222 BY SIMILARITY. FT CARBOHYD 298 298 POTENTIAL. FT CARBOHYD 471 471 POTENTIAL. FT LIPID 475 475 GPI-ANCHOR (BY SIMILARITY). SQ SEQUENCE 492 AA; 53271 MW; 03F2B64A CRC32; MATGRAKNTK WARWLSTAGL IIVVTLPATT MAAERTGLKA TAWKPLCKLT TELSKVSGEM LNKGQEVISN IQKIKAAEYK VSIYLAKNPE TQALQQSTLL RGYFARKTNG GLESYKTMGL ATQIRSARAA AYLKGSIDEF LNLLESLKGG SENKCLVTTN ADTAATRRET KLDDQECALS MPETKPEAAT RTELTQTGYP NLQHGGGGTA NTFQPTTSTG TCKLLSGHST NGYPTTSALD TTAKVLAGYM TIPNTQVEAT LANMQAMGNG HKATAPAWHE AWEARNREAK AKDLAYTNET GNLDTQPTLK ALVKTLLLPK DNTEHNAEAT KLEALFGGLA ADKTKTYLDM VDAEIIPAGI AGRTTEAPLG KIHDTVELGD ILSNYEMIAA QNVVTLKKNL DAVSKKQQTE SAENKEKICN AAKDNQKACE NLKEKGCVFN TESNKCELKK DVKEKLEKES KETEGKDEKA NTTGSNSFLI HKAPLLLAFL LF //