ID VSI4_TRYBB STANDARD; PRT; 514 AA. AC P26329; DT 01-MAY-1992 (REL. 22, CREATED) DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE) DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE) DE VARIANT SURFACE GLYCOPROTEIN ILTAT 1.24 PRECURSOR (VSG). OS TRYPANOSOMA BRUCEI BRUCEI. OC EUKARYOTA; PROTOZOA; SARCOMASTIGOPHORA; MASTIGOPHORA; KINETOPLASTIDA; OC TRYPANOSOMATIDAE. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=ISOLATE MIAG 209; RX MEDLINE; 92046037. RA CARRINGTON M., MILLER N., BLUM M., RODITI I., WILEY D., TURNER M.; RL J. MOL. BIOL. 221:823-835(1991). CC -!- FUNCTION: VSG FORMS A COAT ON THE SURFACE OF THE PARASITE. THE CC TYPANOSOME EVADES THE IMMUNE RESPONSE OF THE HOST BY EXPRESSING CC A SERIES OF ANTIGENICALLY DISTINCT VSGS FROM AN ESTIMATED 1000 CC VSG GENES. CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC A SOLUBLE FORM IS RELASED FROM RUPTURED CELLS BY THE ACTION OF A CC PI-PLC. DR EMBL; X56767; G10454; -. DR PIR; S18449; S18449. KW GLYCOPROTEIN; ANTIGEN; TRYPANOSOMIASIS; GPI-ANCHOR; MEMBRANE; SIGNAL. FT SIGNAL 1 23 FT CHAIN 24 491 VARIANT SURFACE GLYCOPROTEIN ILTAT 1.24. FT PROPEP 492 514 HYDROPHOBIC, REMOVED DURING MATURATION. FT CARBOHYD 443 443 POTENTIAL. FT LIPID 491 491 GPI-ANCHOR (BY SIMILARITY). SQ SEQUENCE 514 AA; 55169 MW; 6C05EB89 CRC32; MVYRNILQLS VLKVLLIVLI VEATHFGVKY ELWQPECELT AELRKTAGVA KMKVNSDLNS FKTLELTKMK LLTFAAKFPE SKEALTLRAL EAALNTDLRA LRDNIANGID RAVRATAYAS EAAGALFSGI QTLHDATDGT TYCLSASGQG SNGNAAMASQ GCKPLALPEL LTEDSYNTDV ISDKGFPKIS PLTNAQGQGK SGECGLFQAA SGAQATNTGV QFSGGSRINL GLGAIVASAA QQPTRPDLSD FSGTARNQAD TLYGKAHASI TELLQLAQGP KPGQTEVETM KLLAQKTAAL DSIKFQLAAS TGKKTSDYKE DENLKTEYFG KTESNIEALW NKVKEEKVKG ADPEDPSKES KISDLNTEEQ LQRVLDYYAV ATMLKLAKQA EDIAKLETEI ADQRGKSPEA ECNKITEEPK CSEEKICSWH KEVKAGEKNC QFNSTKASKS GVPVTQTQTA GADTTAEKCK GKGEKDCKSP DCKWEGGTCK DSSILANKQF ALSVASAAFV ALLF //