ID VSG4_TRYBR STANDARD; PRT; 476 AA. AC P02897; DT 21-JUL-1986 (REL. 01, CREATED) DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE) DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE) DE VARIANT SURFACE GLYCOPROTEIN 4 PRECURSOR (VSG 4) (METACYCLIC VARIABLE DE ANTIGEN) (FRAGMENT). OS TRYPANOSOMA BRUCEI RHODESIENSE. OC EUKARYOTA; PROTOZOA; SARCOMASTIGOPHORA; MASTIGOPHORA; KINETOPLASTIDA; OC TRYPANOSOMATIDAE. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 85038570. RA LENARDO M.J., RICE-FICHT A.C., KELLY G., ESSER K.M., DONELSON J.E.; RL PROC. NATL. ACAD. SCI. U.S.A. 81:6642-6646(1984). CC -!- FUNCTION: VSG FORMS A COAT ON THE SURFACE OF THE PARASITE. THE CC TYPANOSOME EVADES THE IMMUNE RESPONSE OF THE HOST BY EXPRESSING CC A SERIES OF ANTIGENICALLY DISTINCT VSGS FROM AN ESTIMATED 1000 CC VSG GENES. CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC A SOLUBLE FORM IS RELASED FROM RUPTURED CELLS BY THE ACTION OF A CC PI-PLC. DR PIR; A03392; VMUT4R. KW GLYCOPROTEIN; ANTIGEN; TRYPANOSOMIASIS; GPI-ANCHOR; MEMBRANE; SIGNAL. FT SIGNAL 1 ? FT CHAIN ? 457 VARIANT SURFACE GLYCOPROTEIN 4. FT PROPEP 458 >476 HYDROPHOBIC, REMOVED DURING MATURATION. FT DISULFID 38 160 BY SIMILARITY. FT DISULFID 144 203 BY SIMILARITY. FT CARBOHYD 356 356 POTENTIAL. FT LIPID 457 457 GPI-ANCHOR. FT NON_TER 476 476 SQ SEQUENCE 476 AA; 50723 MW; FAFFC79C CRC32; MPTAGAVLLL ATAAVLSRPA AAANEKKPLT ISAAGAVCGF SNELKEVASF AATKVNAYLT ETEQLGTLAV DFCAAIFNGN GKPTAGEVYA ALLAAKTQTD RQAQQQKLVT GALLASSLCS QQAGHIESFI HVFYQAHRDA TTTCIYKSDE HQRKAADVPC VNNGGGLNKI TITTRATKPQ LNSKYKAIVA GTTPNGAAAE KNCKLVNGEQ SQNVFLASQT TNIALKWGDG LLTVPIGDTA ISASNWEPNN KDSIASGNYK ECAAALEQVP PRQSTATAAA SKLLKLEAED DPKLEEELIS KNSFYGDFPI SNVKITATDF SSLHSKLKSY RKKHTADGHQ LLKAKLQHLE KQMQMNATAC KLGAEISSGE PSTAKTTTSG RCEGKAKTAC PKSDYRQREE KDGKEECKPK SGEEQKTQTT GAGEGAADKK EEKCKGKLEP ECTKAPECKW EGETCKDSSI LVNKQFTLSM ISAAFM //