ID   UPAR_HUMAN     STANDARD;      PRT;   335 AA.
AC   Q03405;
DT   01-FEB-1994 (REL. 28, CREATED)
DT   01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT   01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE)
DE   UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR, GPI-ANCHORED FORM
DE   PRECURSOR (U-PAR) (MONOCYTE ACTIVATION ANTIGEN MO3) (CD87 ANTIGEN).
GN   PLAUR OR UPAR OR MO3.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A., AND SEQUENCE OF 23 AND 26-33.
RX   MEDLINE; 90151622.
RA   ROLDAN A.L., CUBELLIS M.V., MASUCCI M.T., BEHRENDT N., LUND L.R.,
RA   DANO K., APPELLA E., BLASI F.;
RL   EMBO J. 9:467-474(1990).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 92268511.
RA   MIN H.Y., SEMNANI R., MIZUKAMI I.F., WATT K., TODD R.F. III, LIU D.Y.;
RL   J. IMMUNOL. 148:3636-3642(1992).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   TISSUE=PLACENTA;
RX   MEDLINE; 94325556.
RA   CASEY J.R., PETRANKA J.G., KOTTRA J., FLEENOR D.E., ROSSE W.F.;
RL   BLOOD 84:1151-1156(1994).
RN   [4]
RP   PARTIAL SEQUENCE.
RX   MEDLINE; 90202929.
RA   BEHRENDT N., RONNE E., PLOUG M., PETRI T., LOBER D., NIELSEN L.S.,
RA   SCHLEUNING W.-D., BLASI F., APPELLA E., DANO K.;
RL   J. BIOL. CHEM. 265:6453-6460(1990).
RN   [5]
RP   SEQUENCE OF 106-116, AND CLEAVAGE BY U-PA.
RX   MEDLINE; 97182578.
RA   HOYER-HANSEN G., PLOUG M., BEHRENDT N., RONNE E., DANO K.;
RL   EUR. J. BIOCHEM. 243:21-26(1997).
RN   [6]
RP   DISULFIDE BONDS, AND PARTIAL SEQUENCE.
RX   MEDLINE; 93352546.
RA   PLOUG M., KJALKE M., RONNE E., WEIDLE U., HOYER-HANSEN G., DANO K.;
RL   J. BIOL. CHEM. 268:17539-17546(1993).
CC   -!- FUNCTION: ACTS AS A RECEPTOR FOR UROKINASE PLASMINOGEN ACTIVATOR.
CC       PLAYS A ROLE IN LOCALIZING AND PROMOTING PLASMIN FORMATION.
CC       MEDIATES THE PROTEOLYSIS-INDEPENDENT SIGNAL TRANSDUCTION
CC       ACTIVATION EFFECTS OF U-PA. IT IS SUBJECT TO NEGATIVE-FEEDBACK
CC       REGULATION BY U-PA WHICH CLEAVES IT INTO AN INACTIVE FORM.
CC   -!- SUBUNIT: MONOMER (PROBABLE).
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC   -!- ALTERNATIVE PRODUCTS: TWO FORMS OF U-PAR ARE PRODUCED BY SPLICING
CC       OF THE SAME GENE. THE LONG FORM IS GPI-ANCHORED TO THE MEMBRANE;
CC       WHILE THE SHORT FORM SEEMS TO BE SECRETED.
CC   -!- SIMILARITY: CONTAINS 3 UPAR/LY6 DOMAINS.
CC   -!- DATABASE: NAME=PROW; NOTE=CD guide CD87 entry;
CC       WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd87.htm".
DR   EMBL; X51675; G37605; -.
DR   EMBL; M83246; G188624; -.
DR   EMBL; U09937; G533376; -.
DR   EMBL; U09931; G533376; JOINED.
DR   EMBL; U09932; G533376; JOINED.
DR   EMBL; U09933; G533376; JOINED.
DR   EMBL; U09935; G533376; JOINED.
DR   EMBL; U09936; G533376; JOINED.
DR   EMBL; A18757; G512464; -.
DR   PIR; S12376; S12376.
DR   HSSP; P01426; 1NEA.
DR   MIM; 173391; -.
DR   PROSITE; PS00983; LY6_UPAR; 3.
KW   RECEPTOR; SIGNAL; GLYCOPROTEIN; GPI-ANCHOR; REPEAT.
FT   SIGNAL        1     22
FT   CHAIN        23   ?305       UROKINASE PLASMINOGEN ACTIVATOR SURFACE
FT                                RECEPTOR, GPI-ANCHORED FORM.
FT   PROPEP     ?306    335       REMOVED IN MATURE FORM (POTENTIAL).
FT   DOMAIN       23    114       UPAR/LY6 1.
FT   DOMAIN      115    213       UPAR/LY6 2.
FT   DOMAIN      214    305       UPAR/LY6 3.
FT   CARBOHYD     74     74
FT   CARBOHYD    184    184       POTENTIAL.
FT   CARBOHYD    194    194       POTENTIAL.
FT   CARBOHYD    222    222       POTENTIAL.
FT   CARBOHYD    255    255       POTENTIAL.
FT   DISULFID     25     46
FT   DISULFID     28     34
FT   DISULFID     39     67
FT   DISULFID     93     98
FT   DISULFID    117    144       POTENTIAL.
FT   DISULFID    120    127       POTENTIAL.
FT   DISULFID    137    169       POTENTIAL.
FT   DISULFID    175    192       POTENTIAL.
FT   DISULFID    193    198       POTENTIAL.
FT   DISULFID    216    244       POTENTIAL.
FT   DISULFID    219    227       POTENTIAL.
FT   DISULFID    237    263       POTENTIAL.
FT   DISULFID    269    287       POTENTIAL.
FT   DISULFID    288    293       POTENTIAL.
FT   LIPID       305    305       GPI-ANCHOR (POTENTIAL).
FT   SITE        105    106       CLEAVAGE (BY U-PA).
FT   SITE        111    112       CLEAVAGE (BY U-PA).
FT   CONFLICT     28     28       C -> N (IN AA SEQUENCE).
SQ   SEQUENCE   335 AA;  36978 MW;  CC90F46E CRC32;
     MGHPPLLPLL LLLHTCVPAS WGLRCMQCKT NGDCRVEECA LGQDLCRTTI VRLWEEGEEL
     ELVEKSCTHS EKTNRTLSYR TGLKITSLTE VVCGLDLCNQ GNSGRAVTYS RSRYLECISC
     GSSDMSCERG RHQSLQCRSP EEQCLDVVTH WIQEGEEGRP KDDRHLRGCG YLPGCPGSNG
     FHNNDTFHFL KCCNTTKCNE GPILELENLP QNGRQCYSCK GNSTHGCSSE ETFLIDCRGP
     MNQCLVATGT HEPKNQSYMV RGCATASMCQ HAHLGDAFSM NHIDVSCCTK SGCNHPDLDV
     QYRSGAAPQP GPAHLSLTIT LLMTARLWGG TLLWT
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