ID TREA_HUMAN STANDARD; PRT; 583 AA. AC O43280; DT 15-JUL-1998 (REL. 36, CREATED) DT 15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE TREHALASE PRECURSOR (EC 3.2.1.28) (ALPHA,ALPHA-TREHALASE) DE (ALPHA,ALPHA-TREHALOSE GLUCOHYDROLASE). GN TREA. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=KIDNEY; RX MEDLINE; 98087419. RA ISHIHARA R., TAKETANI S., SASAI-TAKEDATSU M., KINO M., TOKUNAGA R., RA KOBAYASHI Y.; RL GENE 202:69-74(1997). RN [2] RP PARTIAL SEQUENCE. RA SASAI-TAKEDATSU M., TAKETANI S., NAGATA N., FURUKAWA T., TOKUNAGA R., RA KOJIMA T., KOBAYASHI Y.; RL NEPHRON 73:179-185(1996). CC -!- FUNCTION: INTESTINAL TREHALASE IS PROBABLY INVOLVED IN THE CC HYDROLYSIS OF INGESTED TREHALOSE. CC -!- CATALYTIC ACTIVITY: ALPHA,ALPHA-TREHALOSE + H(2)O = 2 D-GLUCOSE. CC -!- SUBUNIT: HOMODIMER, DISULFIDE-LINKED (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- SIMILARITY: BELONGS TO FAMILY 37 OF GLYCOSYL HYDROLASES. DR EMBL; AB000824; D1025293; -. DR MIM; 275360; -. DR PROSITE; PS00927; TREHALASE_1; 1. DR PROSITE; PS00928; TREHALASE_2; 1. KW HYDROLASE; GLYCOSIDASE; GLYCOPROTEIN; SIGNAL; GPI-ANCHOR. FT SIGNAL 1 19 OR 20, OR 21 (POTENTIAL). FT CHAIN 20 559 TREHALASE. FT PROPEP 560 583 REMOVED IN MATURE FORM (BY SIMILARITY). #FT LIPID 559 559 GPI-ANCHOR (BY SIMILARITY). FT LIPID 556 556 GPI-ANCHOR (BY SIMILARITY). FT CARBOHYD 78 78 POTENTIAL. FT CARBOHYD 239 239 POTENTIAL. FT CARBOHYD 261 261 POTENTIAL. FT CARBOHYD 369 369 POTENTIAL. SQ SEQUENCE 583 AA; 66596 MW; 25E6EB96 CRC32; MPGRTWELCL LLLLGLGLGS QEALPPPCES EIYCHGELLN QVQMAKLYQD DKQFVDMPLS IAPEQVLQTF TELSRDHNHS IPREQLQAFV HEHFQAKGQE LQPWTPADWK DSPQFLQKIS DAKLRAWAGQ LHQLWKKLGK KMKPEVLSHP ERFSLIYSEH PFIVPGGRFV EFYYWDSYWV MEGLLLSEMA ETVKGMLQNF LDLVKTYGHV PNGGRVYYLQ RSQPPLLTLM MDCYLTHTND TAFLQENIET LALELDFWTK NRTVSVSLEG KNYLLNRYYV PYGGPRPESY SKDVELADTL PEGDREALWA ELKAGAESGW DFSSRWLIGG PNPNSLSGIR TSKLVPVDLN AFLCQAEELM SNFYSRLGND SQATKYRILR SQRLAALNTV LWDEQTGAWF DYDLEKKKKN REFYPSNLTP LWAGCFSDPG VADKALKYLE DNRILTYQYG IPTSLQKTGQ QWDFPNAWAP LQDLVIRGLA KAPLRRAQEV AFQLAQNWIR TNFDVYSQKS AMYEKYDVSN GGQPGGGGEY EVQEGFGWDE GVVLMLLDRY GDRLTSGAKL AFLEPHCLAA TLLPSLLLSL LPW //