ID PRIO_MANSP STANDARD; PRT; 241 AA. AC P40255; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) DE MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) (FRAGMENT). GN PRNP. OS MANDRILLUS SPHINX (MANDRILL) (PAPIO SPHINX). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 95139066. RA SCHATZL H.M., DACOSTA M., TAYLOR L., COHEN F.E., PRUSINER S.B.; RL J. MOL. BIOL. 245:362-374(1995). CC -!- FUNCTION: THE FUNCTION OF PRP IS NOT KNOWN. PRP IS ENCODED IN THE CC HOST GENOME AND IS EXPRESSED BOTH IN NORMAL AND INFECTED CELLS. CC -!- SUBUNIT: PRP HAS A TENDENCY TO AGGREGATE YIELDING POLYMERS CALLED CC "RODS". CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- DISEASE: PRP IS FOUND IN HIGH QUANTITY IN THE BRAIN OF HUMANS AND CC ANIMALS INFECTED WITH THE DEGENERATIVE NEUROLOGICAL DISEASES KURU, CC CREUTZFELDT-JAKOB DISEASE (CJD), GERSTMANN-STRAUSSLER SYNDROME CC (GSS), SCRAPIE, BOVINE SPONGIFORM ENCEPHALOPATHY (BSE), CC TRANSMISSIBLE MINK ENCEPHALOPATHY (TME), ETC. CC -!- SIMILARITY: BELONGS TO THE PRION FAMILY. DR EMBL; U08303; G474365; -. DR PROSITE; PS00291; PRION_1; 1. DR PROSITE; PS00706; PRION_2; 1. KW PRION; BRAIN; GLYCOPROTEIN; GPI-ANCHOR; REPEAT; SIGNAL. FT NON_TER 1 1 FT SIGNAL <1 15 BY SIMILARITY. FT CHAIN 16 223 MAJOR PRION PROTEIN. FT PROPEP 224 >241 REMOVED IN MATURE FORM (BY SIMILARITY). FT LIPID 223 223 GPI-ANCHOR (BY SIMILARITY). FT DISULFID 172 207 BY SIMILARITY. FT CARBOHYD 174 174 POTENTIAL. FT CARBOHYD 190 190 POTENTIAL. FT DOMAIN 44 84 5 X 8 AA TANDEM REPEATS OF P-H-G-G-G-W-G- FT Q. FT REPEAT 44 52 1. FT REPEAT 53 60 2. FT REPEAT 61 68 3. FT REPEAT 69 76 4. FT REPEAT 77 84 5. FT NON_TER 241 241 SQ SEQUENCE 241 AA; 26398 MW; C155E239 CRC32; MLVLFVATWS DLGLCKKRPK PGGWNTGGSR YPGQGSPGGN RYPPQGGGGW GQPHGGGWGQ PHGGGWGQPH GGGWGQPHGG GWGQGGGTHN QWHKPNKPKT SMKHMAGAAA AGAVVGGLGG YMLGSAMSRP LIHFGNDYED RYYRENMYRY PNQVYYRPVD QYSNQNNFVH DCVNITIKQH TVTTTTKGEN FTETDVKMME RVVEQMCITQ YEKESQAYYQ RGSSMVLFSS PPVILLISFL I //