ID   PRIO_MACFA     STANDARD;      PRT;   253 AA.
AC   P40254;
DT   01-FEB-1995 (REL. 31, CREATED)
DT   01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE)
DT   01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
DE   MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C).
GN   PRNP.
OS   MACACA FASCICULARIS (CRAB EATING MACAQUE) (CYNOMOLGUS MONKEY),
OS   MACACA ARCTOIDES (STUMP-TAILED MACAQUE), MACACA FUSCATA FUSCATA
OS   (JAPANESE MACAQUE), MACACA MULATTA (RHESUS MACAQUE), MACACA NEMESTRINA
OS   (PIG-TAILED MACAQUE), AND PAPIO HAMADRYAS (HAMADRYAS BABOON).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 95139066.
RA   SCHATZL H.M., DACOSTA M., TAYLOR L., COHEN F.E., PRUSINER S.B.;
RL   J. MOL. BIOL. 245:362-374(1995).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   SPECIES=M.MULATTA; TISSUE=BRAIN;
RX   MEDLINE; 95083661.
RA   CERVENAKOVA L., BROWN P., GOLDFARB L.G., NAGLE J., PETTRONE K.,
RA   RUBENSTEIN R., DUBNICK M., GIBBS C.J., GAJDUSEK D.C.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 91:12159-12162(1994).
CC   -!- FUNCTION: THE FUNCTION OF PRP IS NOT KNOWN. PRP IS ENCODED IN THE
CC       HOST GENOME AND IS EXPRESSED BOTH IN NORMAL AND INFECTED CELLS.
CC   -!- SUBUNIT: PRP HAS A TENDENCY TO AGGREGATE YIELDING POLYMERS CALLED
CC       "RODS".
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC   -!- DISEASE: PRP IS FOUND IN HIGH QUANTITY IN THE BRAIN OF HUMANS AND
CC       ANIMALS INFECTED WITH THE DEGENERATIVE NEUROLOGICAL DISEASES KURU,
CC       CREUTZFELDT-JAKOB DISEASE (CJD), GERSTMANN-STRAUSSLER SYNDROME
CC       (GSS), SCRAPIE, BOVINE SPONGIFORM ENCEPHALOPATHY (BSE),
CC       TRANSMISSIBLE MINK ENCEPHALOPATHY (TME), ETC.
CC   -!- SIMILARITY: BELONGS TO THE PRION FAMILY.
DR   EMBL; U08298; G474355; -.
DR   EMBL; U08311; G475584; -.
DR   EMBL; U08301; G474361; -.
DR   EMBL; U08307; G474373; -.
DR   EMBL; U08306; G474371; -.
DR   EMBL; U08294; G474347; -.
DR   EMBL; U15163; G595851; -.
DR   PROSITE; PS00291; PRION_1; 1.
DR   PROSITE; PS00706; PRION_2; 1.
KW   PRION; BRAIN; GLYCOPROTEIN; GPI-ANCHOR; REPEAT; SIGNAL.
FT   SIGNAL        1     22       BY SIMILARITY.
FT   CHAIN        23    230       MAJOR PRION PROTEIN.
FT   PROPEP      231    253       REMOVED IN MATURE FORM (BY SIMILARITY).
FT   LIPID       230    230       GPI-ANCHOR (BY SIMILARITY).
FT   DISULFID    179    214       BY SIMILARITY.
FT   CARBOHYD    181    181       POTENTIAL.
FT   CARBOHYD    197    197       POTENTIAL.
FT   DOMAIN       51     91       5 X 8 AA TANDEM REPEATS OF P-H-G-G-G-W-G-
FT                                Q.
FT   REPEAT       51     59       1.
FT   REPEAT       60     67       2.
FT   REPEAT       68     75       3.
FT   REPEAT       76     83       4.
FT   REPEAT       84     91       5.
SQ   SEQUENCE   253 AA;  27676 MW;  F98D1285 CRC32;
     MANLGCWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGGWGQP
     HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHNQWH KPSKPKTSMK HMAGAAAAGA
     VVGGLGGYML GSAMSRPLIH FGNDYEDRYY RENMYRYPNQ VYYRPVDQYS NQNNFVHDCV
     NITIKQHTVT TTTKGENFTE TDVKMMERVV EQMCITQYEK ESQAYYQRGS SMVLFSSPPV
     ILLISFLIFL IVG
//