ID PRIO_CRIMI STANDARD; PRT; 254 AA. AC Q60468; DT 15-JUL-1998 (REL. 36, CREATED) DT 15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C). GN PRNP. OS CRICETULUS MIGRATORIUS (ARMENIAN HAMSTER). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RX MEDLINE; 90158578. RA LOWENSTEIN D.H., BUTLER D.A., WESTAWAY D., MCKINLEY M.P., RA DEARMOND S.J., PRUSINER S.B.; RL MOL. CELL. BIOL. 10:1153-1163(1990). CC -!- FUNCTION: THE FUNCTION OF PRP IS NOT KNOWN. PRP IS ENCODED IN THE CC HOST GENOME AND IS EXPRESSED BOTH IN NORMAL AND INFECTED CELLS. CC -!- SUBUNIT: PRP HAS A TENDENCY TO AGGREGATE YIELDING POLYMERS CALLED CC "RODS". CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- DISEASE: FOUND IN HIGH QUANTITY IN THE BRAIN OF HUMANS AND ANIMALS CC INFECTED WITH DEGENERATIVE NEUROLOGICAL DISEASES SUCH AS KURU, CC CREUTZFELDT-JAKOB DISEASE (CJD), GERSTMANN-STRAUSSLER SYNDROME CC (GSS), SCRAPIE, BOVINE SPONGIFORM ENCEPHALOPATHY (BSE), CC TRANSMISSIBLE MINK ENCEPHALOPATHY (TME), ETC. CC -!- SIMILARITY: BELONGS TO THE PRION FAMILY. DR EMBL; M33959; G191183; -. DR PROSITE; PS00291; PRION_1; 1. DR PROSITE; PS00706; PRION_2; 1. KW PRION; BRAIN; GLYCOPROTEIN; GPI-ANCHOR; REPEAT; SIGNAL. FT SIGNAL 1 22 BY SIMILARITY. FT CHAIN 23 231 MAJOR PRION PROTEIN. FT PROPEP 232 254 REMOVED IN MATURE FORM. FT LIPID 231 231 GPI-ANCHOR. FT DOMAIN 90 231 PRP27-30 (PROTEASE RESISTANT CORE). FT CARBOHYD 181 181 BY SIMILARITY. FT CARBOHYD 197 197 BY SIMILARITY. FT DISULFID 179 214 BY SIMILARITY. FT DOMAIN 51 91 5 X 8 AA TANDEM REPEATS OF P-H-G-G-G-W-G- FT Q. FT REPEAT 51 59 1. FT REPEAT 60 67 2. FT REPEAT 68 75 3. FT REPEAT 76 83 4. FT REPEAT 84 91 5. SQ SEQUENCE 254 AA; 27855 MW; 3F92FCC8 CRC32; MANLSYWLLA LFVATWTDVG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGTWGQP HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHNQWN KPNKPKTSMK HMAGAAAAGA VVGGLGGYML GSAMSRPMLH FGNDWEDRYY RENMNRYPNQ VYYRPVDQYN NQNNFVHDCV NITIKQHTVT TTTKGENFTE TDVKMMERVV EQMCVTQYQK ESQAYYDGRR SSAVLFSSPP VILLISFLIF LIVG //