ID PRIO_COLGU STANDARD; PRT; 253 AA. AC P40251; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C). GN PRNP. OS COLOBUS GUEREZA. OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 95139066. RA SCHATZL H.M., DACOSTA M., TAYLOR L., COHEN F.E., PRUSINER S.B.; RL J. MOL. BIOL. 245:362-374(1995). RN [2] RP SEQUENCE OF 8-253 FROM N.A. RA DER KUYL A.C., DEKKER J.T., GOUDSMIT J.; RL SUBMITTED (OCT-1996) TO EMBL/GENBANK/DDBJ DATA BANKS. CC -!- FUNCTION: THE FUNCTION OF PRP IS NOT KNOWN. PRP IS ENCODED IN THE CC HOST GENOME AND IS EXPRESSED BOTH IN NORMAL AND INFECTED CELLS. CC -!- SUBUNIT: PRP HAS A TENDENCY TO AGGREGATE YIELDING POLYMERS CALLED CC "RODS". CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- DISEASE: PRP IS FOUND IN HIGH QUANTITY IN THE BRAIN OF HUMANS AND CC ANIMALS INFECTED WITH THE DEGENERATIVE NEUROLOGICAL DISEASES KURU, CC CREUTZFELDT-JAKOB DISEASE (CJD), GERSTMANN-STRAUSSLER SYNDROME CC (GSS), SCRAPIE, BOVINE SPONGIFORM ENCEPHALOPATHY (BSE), CC TRANSMISSIBLE MINK ENCEPHALOPATHY (TME), ETC. CC -!- SIMILARITY: BELONGS TO THE PRION FAMILY. DR EMBL; U08297; G474353; -. DR EMBL; U75389; G1658469; -. DR PROSITE; PS00291; PRION_1; 1. DR PROSITE; PS00706; PRION_2; 1. KW PRION; BRAIN; GLYCOPROTEIN; GPI-ANCHOR; REPEAT; SIGNAL. FT SIGNAL 1 22 BY SIMILARITY. FT CHAIN 23 230 MAJOR PRION PROTEIN. FT PROPEP 231 253 REMOVED IN MATURE FORM (BY SIMILARITY). FT LIPID 230 230 GPI-ANCHOR (BY SIMILARITY). FT DISULFID 179 214 BY SIMILARITY. FT CARBOHYD 181 181 POTENTIAL. FT CARBOHYD 197 197 POTENTIAL. FT DOMAIN 51 91 5 X 8 AA TANDEM REPEATS OF P-H-G-G-G-W-G- FT Q. FT REPEAT 51 59 1. FT REPEAT 60 67 2. FT REPEAT 68 75 3. FT REPEAT 76 83 4. FT REPEAT 84 91 5. SQ SEQUENCE 253 AA; 27626 MW; E23C0B49 CRC32; MANLGCWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGGWGQP HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHSQWN KPSKPKTSMK HMAGAAAAGA VVGGLGGYML GSAMSRPLIH FGNDYEDRYY RENMYRYPNQ VYYRPVDQYS NQNNFVHDCV NITIKQHTVT TTTKGENFTE TDVKMMERVV EQMCITQYEK ESQAYYQRGS SMVLFSSPPV ILLISFLIFL IVG //