ID PRIO_CERAT STANDARD; PRT; 238 AA. AC Q95145; Q95200; DT 01-NOV-1997 (REL. 35, CREATED) DT 01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C) (FRAGMENT). GN PRNP. OS CERCOCEBUS ATERRIMUS, AND MACACA SYLVANUS (BARBARY APE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RA DER KUYL A.C., DEKKER J.T., GOUDSMIT J.; RL SUBMITTED (NOV-1996) TO EMBL/GENBANK/DDBJ DATA BANKS. CC -!- FUNCTION: THE FUNCTION OF PRP IS NOT KNOWN. PRP IS ENCODED IN THE CC HOST GENOME AND IS EXPRESSED BOTH IN NORMAL AND INFECTED CELLS. CC -!- SUBUNIT: PRP HAS A TENDENCY TO AGGREGATE YIELDING POLYMERS CALLED CC "RODS". CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- DISEASE: PRP IS FOUND IN HIGH QUANTITY IN THE BRAIN OF HUMANS AND CC ANIMALS INFECTED WITH THE DEGENERATIVE NEUROLOGICAL DISEASES KURU, CC CREUTZFELDT-JAKOB DISEASE (CJD), GERSTMANN-STRAUSSLER SYNDROME CC (GSS), SCRAPIE, BOVINE SPONGIFORM ENCEPHALOPATHY (BSE), CC TRANSMISSIBLE MINK ENCEPHALOPATHY (TME), ETC. CC -!- SIMILARITY: BELONGS TO THE PRION FAMILY. DR EMBL; U75384; G1658467; -. DR EMBL; U75382; G1658479; -. DR PROSITE; PS00291; PRION_1; 1. DR PROSITE; PS00706; PRION_2; 1. KW PRION; BRAIN; GLYCOPROTEIN; GPI-ANCHOR; REPEAT; SIGNAL. FT NON_TER 1 1 FT SIGNAL <1 15 BY SIMILARITY. FT CHAIN 16 215 MAJOR PRION PROTEIN. FT PROPEP 216 238 REMOVED IN MATURE FORM (BY SIMILARITY). FT LIPID 215 215 GPI-ANCHOR (BY SIMILARITY). FT DISULFID 164 199 BY SIMILARITY. FT CARBOHYD 166 166 POTENTIAL. FT CARBOHYD 182 182 POTENTIAL. FT DOMAIN 44 76 5 X 8 AA TANDEM REPEATS OF P-H-G-G-G-W-G- FT Q. FT REPEAT 44 52 1. FT REPEAT 53 60 2. FT REPEAT 61 68 3. FT REPEAT 69 71 4. FT REPEAT 71 76 5. SQ SEQUENCE 238 AA; 26123 MW; A5CBBDB8 CRC32; MLVLFVATWS DLGLCKKRPK PGGWNTGGSR YPGQGSPGGN RYPPQGGGGW GQPHGGGWGQ PHGGGWGQPH GGGWGQGGGT HNQWHKPSKP KTSMKHMAGA AAAGAVVGGL GGYMLGSAMS RPLIHFGNDY EDRYYRENMY RYPNQVYYRP VDQYSNQNNF VHDCVNITIK QHTVTTTTKG ENFTETDVKM MERVVEQMCI TQYEKESQAY YQRGSSMVLF SSPPVILLIS FLIFLIVG //