ID PRIO_CALJA STANDARD; PRT; 252 AA. AC P40247; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) DE MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30) (PRP33-35C). GN PRNP. OS CALLITHRIX JACCHUS (COMMON MARMOSET). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 95139066. RA SCHATZL H.M., DACOSTA M., TAYLOR L., COHEN F.E., PRUSINER S.B.; RL J. MOL. BIOL. 245:362-374(1995). CC -!- FUNCTION: THE FUNCTION OF PRP IS NOT KNOWN. PRP IS ENCODED IN THE CC HOST GENOME AND IS EXPRESSED BOTH IN NORMAL AND INFECTED CELLS. CC -!- SUBUNIT: PRP HAS A TENDENCY TO AGGREGATE YIELDING POLYMERS CALLED CC "RODS". CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- DISEASE: PRP IS FOUND IN HIGH QUANTITY IN THE BRAIN OF HUMANS AND CC ANIMALS INFECTED WITH THE DEGENERATIVE NEUROLOGICAL DISEASES KURU, CC CREUTZFELDT-JAKOB DISEASE (CJD), GERSTMANN-STRAUSSLER SYNDROME CC (GSS), SCRAPIE, BOVINE SPONGIFORM ENCEPHALOPATHY (BSE), CC TRANSMISSIBLE MINK ENCEPHALOPATHY (TME), ETC. CC -!- SIMILARITY: BELONGS TO THE PRION FAMILY. DR EMBL; U08304; G474367; -. DR PROSITE; PS00291; PRION_1; 1. DR PROSITE; PS00706; PRION_2; 1. KW PRION; BRAIN; GLYCOPROTEIN; GPI-ANCHOR; REPEAT; SIGNAL. FT SIGNAL 1 22 BY SIMILARITY. FT CHAIN 23 229 MAJOR PRION PROTEIN. FT PROPEP 230 252 REMOVED IN MATURE FORM (BY SIMILARITY). FT LIPID 229 229 GPI-ANCHOR (BY SIMILARITY). FT DISULFID 178 213 BY SIMILARITY. FT CARBOHYD 180 180 POTENTIAL. FT CARBOHYD 196 196 POTENTIAL. FT DOMAIN 51 90 5 X 8 AA TANDEM REPEATS OF P-H-G-G-G-W-G- FT Q. FT REPEAT 51 58 1. FT REPEAT 59 66 2. FT REPEAT 67 74 3. FT REPEAT 75 82 4. FT REPEAT 83 90 5. SQ SEQUENCE 252 AA; 27639 MW; 0DD4F5A1 CRC32; MANLGCWMLF LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGWGQPH GGGWGQPHGG GWGQPHGGGW GQPHGGGWGQ GGGTHSQWNK PSKPKTNMKH VAGAAAAGAV VGGLGGYMLG SAMSRPLIHF GNDYEDRYYR ENMYRYPNQV YYRPVDQYNN QNNFVHDCVN ITIKQHTVTT TTKGENFTET DVKMMERVVE QMCITQYEKE SQAYYQRGSS MVLFSSPPVI LLISFLIFLI VG //