ID PPBJ_RAT STANDARD; PRT; 551 AA. AC P51740; DT 01-OCT-1996 (REL. 34, CREATED) DT 01-OCT-1996 (REL. 34, LAST SEQUENCE UPDATE) DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) DE ALKALINE PHOSPHATASE, INTESTINAL 2 PRECURSOR (EC 3.1.3.1) (IAP-II). OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 92062729. RA STROM M., KRISINGER J., DELUCA H.F.; RL BIOCHIM. BIOPHYS. ACTA 1090:299-304(1991). RN [2] RP PARTIAL SEQUENCE FROM N.A. RC STRAIN=SPRAGUE-DAWLEY; RX MEDLINE; 93092310. RA ENGLE M.J., ALEPRS D.H.; RL CLIN. CHEM. 38:2506-2509(1992). RN [3] RP GPI-ANCHOR. RX MEDLINE; 95263539. RA ENGLE M.J., MAHMOOD A., ALPERS D.H.; RL J. BIOL. CHEM. 270:11935-11940(1995). CC -!- CATALYTIC ACTIVITY: AN ORTHOPHOSPHORIC MONOESTER + H(2)O = AN CC ALCOHOL + ORTHOPHOSPHATE (AT A HIGH PH OPTIMUM). CC -!- SUBUNIT: HOMODIMER (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- IN MOST MAMMALS THERE ARE FOUR DIFFERENT ISOZYMES: PLACENTAL, CC PLACENTAL-LIKE, INTESTINAL AND TISSUE NON-SPECIFIC (LIVER/BONE/ CC KIDNEY). RAT HAS TWO GENES FOR THE INTESTINAL ISOZYME. CC -!- SIMILARITY: STRONG TO ALL OTHER MAMMALIAN AP, AND TO BACTERIAL CC AND YEAST AP. DR EMBL; S66545; E91409; -. DR PROSITE; PS00123; ALKALINE_PHOSPHATASE; 1. KW HYDROLASE; ZINC; MAGNESIUM; PHOSPHORYLATION; TRANSMEMBRANE; KW MULTIGENE FAMILY; GLYCOPROTEIN; GPI-ANCHOR; SIGNAL. FT SIGNAL 1 19 POTENTIAL. FT CHAIN 20 531 ALKALINE PHOSPHATASE, INTESTINAL 2. FT PROPEP 532 551 REMOVED IN MATURE FORM (POTENTIAL). FT DOMAIN 511 527 POLY-THR. FT MOD_RES 111 111 PHOSPHORYLATION (BY SIMILARITY). FT ACT_SITE 111 111 BY SIMILARITY. FT LIPID 531 531 GPI-ANCHOR (POTENTIAL). FT CARBOHYD 141 141 POTENTIAL. FT CARBOHYD 241 241 POTENTIAL. FT CARBOHYD 426 426 POTENTIAL. FT CARBOHYD 509 509 POTENTIAL. SQ SEQUENCE 551 AA; 59797 MW; 68D5D002 CRC32; MQGAWVLLLL GFRLQLSLSV IPVEEENPAF WTQKAADALN VAKKLQPIQT SAKNLIIFLG DGMGVATVTA TRILKGQLEG NLGPETPLAM DHFPYMALSK TYSVDRQVPD SASTATAYLC GVKTNYKTIG VSAAARFDQC NTTFGNEVLS VMYRAKKAGK SVGVGDHTRV QHASPAGTYV HTVTSNWYGD ADMPALPLQE GCKDIATQLI SNMDINVILG GGRKYMFPAG TPDPEYPNDV NETGTRLDGK NLVQEWLSKH QGSQYVWNRQ ELIQKSLDPS VTYLMGLFEP VDTKFEIQRD PLMDPSLKDM TEAALHVLSR NPKGFYLFVE GGRIDRGHHL GTAYLALTEA VMFDSAIERA SLQASEQDTL TIVTADHSHV FSFGGYTLRG TSIFGLAPLN ALDGKPYTSI LYGNGPGYVG TGERPNVTDA ESHDPSYQQQ AAVPVKSETT VGKDVAIFAR GPQAHLLHGV QEQNYIAHVM AFAGCLEPYT DCGLAPPADE NRPTTPVQNS TTTTTTTTTT TTTTTTTRVQ NSASSLGPAT APLAWHYWPR R //