ID PPBI_BOVIN STANDARD; PRT; 533 AA. AC P19111; Q28124; DT 01-NOV-1990 (REL. 16, CREATED) DT 01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE ALKALINE PHOSPHATASE, INTESTINAL PRECURSOR (EC 3.1.3.1) (IAP). GN ALPI. OS BOS TAURUS (BOVINE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; ARTIODACTYLA. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=LIVER; RX MEDLINE; 93199526. RA WEISSIG H., SCHILDGE A., HOYLAERTS M.F., IQBAL M., MILLAN J.L.; RL BIOCHEM. J. 290:503-508(1993). RN [2] RP SEQUENCE OF 20-63. RX MEDLINE; 86205956. RA HUA J.-C., BERGER J., PAN Y.C.E., HULMES J.D., UDENFRIEND S.; RL PROC. NATL. ACAD. SCI. U.S.A. 83:2368-2372(1986). CC -!- CATALYTIC ACTIVITY: AN ORTHOPHOSPHORIC MONOESTER + H(2)O = AN CC ALCOHOL + ORTHOPHOSPHATE (AT A HIGH PH OPTIMUM). CC -!- SUBUNIT: HOMODIMER. CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- IN MOST MAMMALS THERE ARE FOUR DIFFERENT ISOZYMES: PLACENTAL, CC PLACENTAL-LIKE, INTESTINAL AND TISSUE NON-SPECIFIC (LIVER/BONE/ CC KIDNEY). CC -!- SIMILARITY: STRONG TO ALL OTHER MAMMALIAN AP, AND TO BACTERIAL CC AND YEAST AP. DR EMBL; L07733; G289416; -. DR PIR; B23531; B23531. DR PROSITE; PS00123; ALKALINE_PHOSPHATASE; 1. KW HYDROLASE; ZINC; MAGNESIUM; PHOSPHORYLATION; TRANSMEMBRANE; KW MULTIGENE FAMILY; GLYCOPROTEIN; GPI-ANCHOR; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 506 ALKALINE PHOSPHATASE, INTESTINAL. FT PROPEP 507 533 REMOVED IN MATURE FORM (BY SIMILARITY). FT LIPID 506 506 GPI-ANCHOR (BY SIMILARITY). FT MOD_RES 111 111 PHOSPHORYLATION (BY SIMILARITY). FT ACT_SITE 111 111 BY SIMILARITY. FT CARBOHYD 268 268 POTENTIAL. FT CARBOHYD 429 429 POTENTIAL. SQ SEQUENCE 533 AA; 57099 MW; CC768CF5 CRC32; MQGACVLLLL GLHLQLSLGL VPVEEEDPAF WNRQAAQALD VAKKLQPIQT AAKNVILFLG DGMGVPTVTA TRILKGQMNG KLGPETPLAM DQFPYVALSK TYNVDRQVPD SAGTATAYLC GVKGNYRTIG VSAAARYNQC KTTRGNEVTS VMNRAKKAGK SVGVVTTTRV QHASPAGAYA HTVNRNWYSD ADLPADAQMN GCQDIAAQLV NNMDIDVILG GGRKYMFPVG TPDPEYPDDA SVNGVRKRKQ NLVQAWQAKH QGAQYVWNRT ALLQAADDSS VTHLMGLFEP ADMKYNVQQD HTKDPTLQEM TEVALRVVSR NPRGFYLFVE GGRIDHGHHD DKAYMALTEA GMFDNAIAKA NELTSELDTL ILVTADHSHV FSFGGYTLRG TSIFGLAPSK ALDSKSYTSI LYGNGPGYAL GGGSRPDVND STSEDPSYQQ QAAVPQASET HGGEDVAVFA RGPQAHLVHG VEEETFVAHI MAFAGCVEPY TDCNLPAPTT ATSIPDAAHL AASPPPLALL AGAMLLLLAP TLY //