ID   PPB3_HUMAN     STANDARD;      PRT;   535 AA.
AC   P05188;
DT   13-AUG-1987 (REL. 05, CREATED)
DT   13-AUG-1987 (REL. 05, LAST SEQUENCE UPDATE)
DT   01-OCT-1994 (REL. 30, LAST ANNOTATION UPDATE)
DE   ALKALINE PHOSPHATASE, PLACENTAL TYPE 3 PRECURSOR (EC 3.1.3.1).
GN   ALPP OR PLAP.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A., AND PARTIAL SEQUENCE.
RX   MEDLINE; 86287303.
RA   HENTHORN P.S., KNOLL B.J., RADUCHA M., ROTHBLUM K.N., SLAUGHTER C.,
RA   WEISS M., LAFFERTY M.A., FISCHER T., HARRIS H.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 83:5597-5601(1986).
CC   -!- CATALYTIC ACTIVITY: AN ORTHOPHOSPHORIC MONOESTER + H(2)O = AN
CC       ALCOHOL + ORTHOPHOSPHATE (AT A HIGH PH OPTIMUM).
CC   -!- SUBUNIT: HOMODIMER.
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC   -!- POLYMORPHISM: PLACENTAL ALP IS HIGHLY POLYMORPHIC, THERE ARE AT
CC       LEAST THREE COMMON ALLELES.
CC   -!- IN MOST MAMMALS THERE ARE FOUR DIFFERENT ISOZYMES: PLACENTAL,
CC       PLACENTAL-LIKE, INTESTINAL AND TISSUE NON-SPECIFIC (LIVER/BONE/
CC       KIDNEY).
CC   -!- SIMILARITY: STRONG TO ALL OTHER MAMMALIAN AP, AND TO BACTERIAL
CC       AND YEAST AP.
DR   EMBL; M14170; G178470; -.
DR   PIR; B24318; B24318.
DR   HSSP; P00634; 1ALK.
DR   MIM; 171800; -.
DR   PROSITE; PS00123; ALKALINE_PHOSPHATASE; 1.
KW   HYDROLASE; ZINC; MAGNESIUM; PHOSPHORYLATION; TRANSMEMBRANE; PLACENTA;
KW   MULTIGENE FAMILY; GLYCOPROTEIN; GPI-ANCHOR; SIGNAL.
FT   SIGNAL        1     22
FT   CHAIN        23    506       ALKALINE PHOSPHATASE, PLACENTAL TYPE 3.
FT   PROPEP      507    535       REMOVED IN MATURE FORM (BY SIMILARITY).
FT   LIPID       506    506       GPI-ANCHOR (BY SIMILARITY).
FT   TRANSMEM    513    529
FT   MOD_RES     114    114       PHOSPHORYLATION.
FT   ACT_SITE    114    114
FT   CARBOHYD    144    144       POTENTIAL.
FT   CARBOHYD    271    271       POTENTIAL.
SQ   SEQUENCE   535 AA;  57826 MW;  F5BB20BC CRC32;
     MLGPCMLLLL LLLGLRLQLS LGIILVEEEN PDFWNREAAE ALGAAKKLQP AQTAAKNLII
     FLGDGVGVST VTAARILKGQ KKDKLGPEIP LAMDRFPYVA LSKTYNVDKH VPDSGATATA
     YLCGVKGNFQ TIGLSAAARF NQCNTTRGNE VISVMNRAKK AGKSVGVVTT TRVQHASPAG
     TYAHTVNRNW YSDADVPASA RQEGCQDIAT QLISNMDIDV ILGGGRKYMF RMGTPDPEYP
     DDYSQGGTRL DGKNLVQEWL AKHQGARYVW NRTELMRASL DPSVAHLMGL FEPGDMKYEI
     HRDSTLDPSL MEMTEAALRL LSRNPRGFFL FVEGGRIDHG HHESRAYRAL TETIMFDDAI
     ERAGQLTSEE DTLSLVTADH SHVFSFGGCP LRGGSIFGLA PGKARDRKAY TVLLYGNGPG
     YVLKDGARPD VTESESGSPE YRQQSAVPLD EETHAGEDVA VFARGPQAHL VHGVQEQTFI
     AHVMAFAACL EPYTACDLAP PAGTTDAAHP GRSVVPALLP LLAGTLLLLE TATAP
//