ID NRTR_CHICK STANDARD; PRT; 465 AA. AC O13157; DT 01-NOV-1997 (REL. 35, CREATED) DT 01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE NEURTURIN RECEPTOR ALPHA PRECURSOR (NTNR-ALPHA) (NRTNR-ALPHA) (GDNF DE RECEPTOR BETA) (GDNFR-BETA). GN GFRA2 OR GDNFRB. OS GALLUS GALLUS (CHICKEN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; AVES; NEOGNATHAE; OC GALLIFORMES. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RA BUJ-BELLO A., ADU J., PINON L.G.P., HORTON A., THOMPSON J., RA ROSENTHAL A., CHINCHETRU M., BUCHMAN V.L., DAVIES A.M.; RL NATURE 387:721-724(1997). CC -!- FUNCTION: RECEPTOR FOR NEURTURIN. MEDIATES THE NRTN-INDUCED CC AUTOPHOSPHORYLATION AND ACTIVATION OF THE RET RECEPTOR. ALSO ABLE CC TO MEDIATE GDNF SIGNALING THROUGH THE RET TYROSINE KINASE CC RECEPTOR (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- SIMILARITY: BELONGS TO THE GDNFR FAMILY. DR EMBL; U90542; G2213805; -. KW RECEPTOR; GLYCOPROTEIN; GPI-ANCHOR; MEMBRANE; SIGNAL. FT SIGNAL 1 21 POTENTIAL. FT CHAIN 22 445 NEURTURIN RECEPTOR ALPHA. FT PROPEP 446 465 HYDROPHOBIC, REMOVED DURING MATURATION FT (POTENTIAL). FT CARBOHYD 355 355 POTENTIAL. FT CARBOHYD 387 387 POTENTIAL. FT CARBOHYD 412 412 POTENTIAL. FT LIPID 445 445 GPI-ANCHOR (POTENTIAL). SQ SEQUENCE 465 AA; 51908 MW; 5CA073E4 CRC32; MILANAFCIV LFVDETLRSL AAPPSPPGQD LQGWRVPVDC IRANKLCAAE GSCSSRYRTL RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMR KEIQCLQVYW SIHLGLAEGE EFYEASPYEP ITSRLSDIFR LASIFSGMDP ATNSKSNHCL DAAKACNLND NCKRLRSGYI STCSKEISAT EHCSRRKCHK ALRQFFDNVP SEYTYRLLFC SCKDQACAEP RRQTIVPFCS YEDKEKPNCL DLRNVCRADH LCRSRLADFH ANCQASFQSL TSCPGDNYQA CLGSYTGLIG FDMTPNYVDA STTSITISPW CSCKGSGNLE EECEKFLRDF TENPCLRNAI QAFGNGTDVN LSPKNPSPPI TMLPKVEKSP ALPDDINDSN TMYDTSIITT CTSIQEHGQK LNKSKEQSLC YSETQLTTDT MPDQKTFVDQ KAAGSRHRAA RILPAVPIVL LKLLL //