ID NRT2_RAT STANDARD; PRT; 275 AA. AC P20974; P97912; Q95576; DT 01-FEB-1991 (REL. 17, CREATED) DT 15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 2 PRECURSOR (EC 2.4.2.31) (T-CELL DE NAD(P)(+)--ARGININE ADP-RIBOSYLTRANSFERASE 2) (T-CELL MONO(ADP- DE RIBOSYL)TRANSFERASE 2) (ALLOANTIGEN RT6.2) (T-CELL SURFACE PROTEIN DE RT6.2). GN ART2B OR RT6-B. OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 90138997. RA KOCH F., HAAG F., KASHAN A., THIELE H.-G.; RL PROC. NATL. ACAD. SCI. U.S.A. 87:964-967(1990). RN [2] RP SEQUENCE OF 1-201 FROM N.A. RC STRAIN=DA; TISSUE=SPLEEN; RX MEDLINE; 96355006. RA HAAG F., KUHLENBAUMER G., KOCH-NOLTE F., WINGENDER E., THIELE H.-G.; RL J. IMMUNOL. 157:2022-2030(1996). RN [3] RP PARTIAL SEQUENCE. RX MEDLINE; 90215814. RA KASHAN A., BUCK F., HAAG F., KOCH F., THIELE H.-G.; RL IMMUNOL. LETT. 23:133-138(1989). RN [4] RP CHARACTERIZATION. RX MEDLINE; 94193612. RA TAKADA T., IIDA K., MOSS J.; RL J. BIOL. CHEM. 269:9420-9423(1994). CC -!- FUNCTION: HAS BOTH NAD+ GLYCOHYDROLASE AND ADP-RIBOSYLTRANSFERASE CC ACTIVITY (TO A LESSER EXTENT). CC -!- CATALYTIC ACTIVITY: NAD(+) + L-ARGININE = NICOTINAMIDE + CC N2-(ADP-D-RIBOSYL)-L-ARGININE. CC -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = NICOTINAMIDE + ADP-RIBOSE. CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- TISSUE SPECIFICITY: POSTTHYMIC T CELLS. CC -!- PTM: TWO DISULFIDE BONDS ARE PRESENT (PROBABLE). CC -!- SIMILARITY: BELONGS TO THE ARG-SPECIFIC ADP-RIBOSYLTRANSFERASE CC FAMILY. DR EMBL; M85193; G206806; -. DR EMBL; X99123; E257753; -. DR EMBL; X99122; E257751; -. DR PIR; A34866; A34866. DR PROSITE; PS01291; ART; 1. KW TRANSFERASE; GLYCOSYLTRANSFERASE; GLYCOPROTEIN; NAD; SIGNAL; KW T-CELL DIFFERENTIATION; GPI-ANCHOR. FT SIGNAL 1 20 FT CHAIN 21 246 T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 2. FT PROPEP 247 275 HYDROPHOBIC, REMOVED DURING MATURATION FT (BY SIMILARITY). FT LIPID 246 246 GPI-ANCHOR (BY SIMILARITY). FT ACT_SITE 209 209 BY SIMILARITY. SQ SEQUENCE 275 AA; 31438 MW; DBEAB84E CRC32; MPSNICKFFL TWWLIQQVTG LTGPLMLDTA PNAFDDQYEG CVNKMEEKAP LLLQEDFNMN AKLKVAWEEA KKRWNNIKPS RSYPKGFNDF HGTALVAYTG SIAVDFNRAV REFKENPGQF HYKAFHYYLT RALQLLSNGD CHSVYRGTKT RFHYTGAGSV RFGQFTSSSL SKKVAQSQEF FSDHGTLFII KTCLGVYIKE FSFRPDQEEV LIPGYEVYQK VRTQGYNEIF LDSPKRKKSN YNCLYSSAGA RESCVSLFLV VLPSLLVQLL CLAEP //