ID   NRT1_RAT       STANDARD;      PRT;   275 AA.
AC   P17982;
DT   01-NOV-1990 (REL. 16, CREATED)
DT   01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT   01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE)
DE   T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 1 PRECURSOR (EC 2.4.2.31) (T-CELL
DE   NAD(P)(+)--ARGININE ADP-RIBOSYLTRANSFERASE 1) (T-CELL MONO(ADP-
DE   RIBOSYL)TRANSFERASE 1) (ALLOANTIGEN RT6.1) (T-CELL SURFACE PROTEIN
DE   RT6.1).
GN   ART2A OR RT6-A.
OS   RATTUS NORVEGICUS (RAT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; RODENTIA.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=LEWIS A;
RX   MEDLINE; 90192088.
RA   HAAG F., KOCH F., THIELE H.-G.;
RL   NUCLEIC ACIDS RES. 18:1047-1047(1990).
RN   [2]
RP   MUTAGENESIS OF GLN-207.
RX   MEDLINE; 96275529.
RA   MAEHAMA T., HOSHINO S.-I., KATADA T.;
RL   FEBS LETT. 388:189-191(1996).
CC   -!- FUNCTION: HAS NAD+ GLYCOHYDROLASE ACTIVITY AND EXTREMELY LOW ADP-
CC       RIBOSYLTRANSFERASE ACTIVITY.
CC   -!- CATALYTIC ACTIVITY: NAD(+) + L-ARGININE = NICOTINAMIDE +
CC       N2-(ADP-D-RIBOSYL)-L-ARGININE.
CC   -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = NICOTINAMIDE + ADP-RIBOSE.
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC   -!- TISSUE SPECIFICITY: POSTTHYMIC T CELLS.
CC   -!- PTM: TWO DISULFIDE BONDS ARE PRESENT (PROBABLE).
CC   -!- SIMILARITY: BELONGS TO THE ARG-SPECIFIC ADP-RIBOSYLTRANSFERASE
CC       FAMILY.
DR   EMBL; X52082; G57168; -.
DR   EMBL; M31138; G206804; -.
DR   PIR; S08464; S08464.
DR   PROSITE; PS01291; ART; 1.
KW   TRANSFERASE; GLYCOSYLTRANSFERASE; GLYCOPROTEIN; NAD; SIGNAL;
KW   T-CELL DIFFERENTIATION; GPI-ANCHOR.
FT   SIGNAL        1     20
FT   CHAIN        21    246       T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 1.
FT   PROPEP      247    275       HYDROPHOBIC, REMOVED DURING MATURATION
FT                                (BY SIMILARITY).
FT   LIPID       246    246       GPI-ANCHOR (BY SIMILARITY).
FT   ACT_SITE    209    209       BY SIMILARITY.
FT   CARBOHYD     58     58       POTENTIAL.
FT   MUTAGEN     207    207       Q->E: INCREASED ADP-RIBOSYLTRANSFERASE
FT                                ACTIVITY.
SQ   SEQUENCE   275 AA;  31388 MW;  523B1A84 CRC32;
     MPSNICKFFL TWWLIQQVTG LTGPLMLDTA PNAFDDQYEG CVNKMEEKAP LLLKEDFNKS
     EKLKVAWEEA KKRWNNIKPS MSYPKGFNDF HGTALVAYTG SIGVDFNRAV REFKENPGQF
     HYKAFHYYLT RALQLLSNGD CHSVYRGTKT RFHYTGAGSV RFGQFTSSSL SKTVAQSPEF
     FSDDGTLFII KTCLGVYIKE FSFYPDQEEV LIPGYEVYQK VRTQGYNEIF LDSPKRKKSN
     YNCLYSSAGT RESCVSLFLV VLTSLLVQLL CLAEP
//