ID   LAMP_RAT       STANDARD;      PRT;   338 AA.
AC   Q62813;
DT   01-NOV-1997 (REL. 35, CREATED)
DT   01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE)
DT   15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE)
DE   LIMBIC SYSTEM-ASSOCIATED MEMBRANE PROTEIN PRECURSOR.
GN   LAMP.
OS   RATTUS NORVEGICUS (RAT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; RODENTIA.
RN   [1]
RP   SEQUENCE FROM N.A., AND SEQUENCE OF 29-49.
RC   TISSUE=HIPPOCAMPUS;
RX   MEDLINE; 95374785.
RA   PIMENTA A.F., ZHUKAREVA V., BARBE M.F., REINOSO B.S., GRIMLEY C.,
RA   HENZEL W., FISCHER I., LEVITT P.;
RL   NEURON 15:287-297(1995).
CC   -!- FUNCTION: MEDIATES SELECTIVE NEURONAL GROWTH AND AXON TARGETING.
CC       CONTRIBUTES TO THE GUIDANCE OF DEVELOPING AXONS AND REMODELING OF
CC       MATURE CIRCUITS IN THE LIMBIC SYSTEM. ESSENTIAL FOR NORMAL GROWTH
CC       OF THE HYPPOCAMPAL MOSSY FIBER PROJECTION.
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC   -!- TISSUE SPECIFICITY: EXPRESSED MOSTLY BY NEURONS COMPRISING LIMBIC-
CC       ASSOCIATED CORTICAL AND SUBCORTICAL REGIONS THAT FUNCTION IN
CC       COGNITION, EMOTION, MEMORY, AND LEARNING.
CC   -!- DEVELOPMENTAL STAGE: FIRST DETECTED AT E15-16, AT STAGE E20 IT IS
CC       DETECTED IN PRESUMPTIVE CORTEX, MEDIAL LIMBIC AREAS OF THE
CC       THALAMUS AND HYPOTHALAMUS. IN THE ADULT, IT IS FOUND IN
CC       HYPOTHALAMUS, PERIRHINAL CORTEX, AMYGDALA AND MEDIAL THALAMIC
CC       REGION.
CC   -!- SIMILARITY: BELONGS TO THE IMMUNOGLOBULIN SUPERFAMILY. CONTAINS
CC       3 C2-LIKE DOMAINS. BELONGS TO THE OBCAM SUBFAMILY.
DR   EMBL; U31554; G951176; -.
KW   IMMUNOGLOBULIN FOLD; CELL ADHESION; GLYCOPROTEIN; GPI-ANCHOR; SIGNAL.
FT   SIGNAL        1     28
FT   CHAIN        29    315       LIMBIC SYSTEM-ASSOCIATED MEMBRANE
FT                                PROTEIN.
FT   PROPEP      316    338       REMOVED IN MATURE FORM (POTENTIAL).
FT   DOMAIN       46    118       IG-LIKE C2-TYPE DOMAIN.
FT   DOMAIN      146    204       IG-LIKE C2-TYPE DOMAIN.
FT   DOMAIN      232    297       IG-LIKE C2-TYPE DOMAIN.
FT   DISULFID     53    111       POTENTIAL.
FT   DISULFID    153    197       POTENTIAL.
FT   DISULFID    239    290       POTENTIAL.
FT   CARBOHYD     40     40       POTENTIAL.
FT   CARBOHYD     66     66       POTENTIAL.
FT   CARBOHYD    136    136       POTENTIAL.
FT   CARBOHYD    148    148       POTENTIAL.
FT   CARBOHYD    279    279       POTENTIAL.
FT   CARBOHYD    287    287       POTENTIAL.
FT   CARBOHYD    300    300       POTENTIAL.
FT   CARBOHYD    315    315       POTENTIAL.
FT   LIPID       315    315       GPI-ANCHOR (POTENTIAL).
SQ   SEQUENCE   338 AA;  37324 MW;  09E54BDB CRC32;
     MVGRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI LRCVVEDKNS
     KVAWLNRSGI IFAGHDKWSL DPRVELEKRH ALEYSLRIQK VDVYDEGSYT CSVQTQHEPK
     TSQVYLIVQV PPKISNISSD VTVNEGSNVT LVCMANGRPE PVITWRHLTP LGREFEGEEE
     YLEILGITRE QSGKYECKAA NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE
     ASAVPAPDFE WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN
     ASLVLFRPGS VRGINGSISL AVPLWLLAAS LFCLLSKC
//