ID LAMP_HUMAN STANDARD; PRT; 338 AA. AC Q13449; DT 01-NOV-1997 (REL. 35, CREATED) DT 01-NOV-1997 (REL. 35, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE LIMBIC SYSTEM-ASSOCIATED MEMBRANE PROTEIN PRECURSOR. GN LAMP. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 96235133. RA PIMENTA A.F., FISCHER I., LEVITT P.; RL GENE 170:189-195(1996). CC -!- FUNCTION: MEDIATES SELECTIVE NEURONAL GROWTH AND AXON TARGETING. CC CONTRIBUTES TO THE GUIDANCE OF DEVELOPING AXONS AND REMODELING OF CC MATURE CIRCUITS IN THE LIMBIC SYSTEM. ESSENTIAL FOR NORMAL GROWTH CC OF THE HYPPOCAMPAL MOSSY FIBER PROJECTION (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- TISSUE SPECIFICITY: EXPRESSED ON LIMBIC NEURONS AND FIBER TRACTS CC AS WEL AS IN SINGLE LAYERS OF THE SUPERIOR COLLICULUS, SPINAL CC CHORD AND CEREBELLUM. CC -!- SIMILARITY: BELONGS TO THE IMMUNOGLOBULIN SUPERFAMILY. CONTAINS CC 3 C2-LIKE DOMAINS. BELONGS TO THE OBCAM SUBFAMILY. DR EMBL; U41901; G1276899; -. KW IMMUNOGLOBULIN FOLD; CELL ADHESION; GLYCOPROTEIN; GPI-ANCHOR; SIGNAL. FT SIGNAL 1 28 POTENTIAL. FT CHAIN 29 315 LIMBIC SYSTEM-ASSOCIATED MEMBRANE FT PROTEIN. FT PROPEP 316 338 REMOVED IN MATURE FORM (POTENTIAL). FT DOMAIN 46 118 IG-LIKE C2-TYPE DOMAIN. FT DOMAIN 146 204 IG-LIKE C2-TYPE DOMAIN. FT DOMAIN 232 297 IG-LIKE C2-TYPE DOMAIN. FT DISULFID 53 111 POTENTIAL. FT DISULFID 153 197 POTENTIAL. FT DISULFID 239 290 POTENTIAL. FT CARBOHYD 40 40 POTENTIAL. FT CARBOHYD 66 66 POTENTIAL. FT CARBOHYD 136 136 POTENTIAL. FT CARBOHYD 148 148 POTENTIAL. FT CARBOHYD 279 279 POTENTIAL. FT CARBOHYD 287 287 POTENTIAL. FT CARBOHYD 300 300 POTENTIAL. FT CARBOHYD 315 315 POTENTIAL. FT LIPID 315 315 GPI-ANCHOR (POTENTIAL). SQ SEQUENCE 338 AA; 37308 MW; DF4014E4 CRC32; MVGRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI LRCVLEDKNS KVAWLNRSGI IFAGHDKWSL DPRVELEKRH SLEYSLRIQK VDVYDEGSYT CSVQTQHEPK TSQVYLIVQV PPKISNISSD VTVNEGSNVT LVCMANGRPE PVITWRHLTP TGREFEGEEE YLEILGITRE QSGKYECKAA NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE ASAVPAPDFE WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN ASLVLFRPGS VRGINGSISL AVPLWLLAAS LLCLLSKC //