ID CD24_HUMAN STANDARD; PRT; 80 AA. AC P25063; DT 01-MAY-1992 (REL. 22, CREATED) DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE SIGNAL TRANSDUCER CD24 PRECURSOR. GN CD24 OR CD24A. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 91332458. RA KAY R., ROSTEN P.M., HUMPHRIES R.K.; RL J. IMMUNOL. 147:1412-1416(1991). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 93007871. RA JACKSON D., WAIBEL R., WEBER E., BELL J., STAHEL R.A.; RL CANCER RES. 52:5264-5270(1992). CC -!- FUNCTION: MODULATES B-CELL ACTIVATION RESPONSES. SIGNALING COULD CC BE TRIGGERED BY THE BINDING OF A LECTIN-LIKE LIGAND TO THE CD24 CC CARBOHYDRATES, AND TRANSDUCED BY THE RELEASE OF SECOND MESSENGERS CC DERIVED FROM THE GPI-ANCHOR. PROMOTES AG-DEPENDENT PROLIFERATION CC OF B-CELLS, AND PREVENTS THEIR TERMINAL DIFFERENTIATION INTO CC ANTIBODY-FORMING CELLS. CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- TISSUE SPECIFICITY: B-CELLS. CC -!- INDUCTION: EXPRESSION IS LOST WHEN PRIMARY B-CELLS ARE INDUCED TO CC DIFFERENTIATE IN ANTIBODY-FORMING CELLS. CC -!- PTM: EXTENSIVELY O-GLYCOSYLATED. CC -!- SIMILARITY: TO OTHER MAMMALIAN SPECIES CD24. CC -!- DATABASE: NAME=PROW; NOTE=CD guide CD24 entry; CC WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd24.htm". DR EMBL; M58664; G180168; -. DR EMBL; X69397; G396168; -. DR EMBL; L33930; G500849; -. DR MIM; 600074; -. KW GLYCOPROTEIN; GPI-ANCHOR; MEMBRANE; SIGNAL. FT SIGNAL 1 26 POTENTIAL. FT CHAIN 27 59 SIGNAL TRANSDUCER CD24. FT PROPEP 60 80 REMOVED IN MATURE FORM (POTENTIAL). FT CARBOHYD 36 36 POTENTIAL. FT CARBOHYD 52 52 POTENTIAL. FT LIPID 59 59 GPI-ANCHOR (POTENTIAL). FT CONFLICT 57 57 A -> V (IN REF. 2). SQ SEQUENCE 80 AA; 8083 MW; F686106F CRC32; MGRAMVARLG LGLLLLALLL PTQIYSSETT TGTSSNSSQS TSNSGLAPNP TNATTKAAGG ALQSTASLFV VSLSLLHLYS //